Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	integrin binding	PDIA4 VWF TNN SRC ADAM2 ITGA4 LYN	1.53e-05	175	91	7	GO:0005178
GeneOntologyMolecularFunction	cell adhesion molecule binding	PDIA4 FLNA FLNB VWF TNN COBLL1 SRC ADAM2 ITGA4 LYN CDH7 CNN3	1.73e-05	599	91	12	GO:0050839
GeneOntologyMolecularFunction	JUN kinase activity	MAPK8 MAPK9	6.14e-05	3	91	2	GO:0004705
GeneOntologyMolecularFunction	phosphatidylserine binding	SYT15 SCARB1 SYT6 SYT1	3.46e-04	73	91	4	GO:0001786
GeneOntologyMolecularFunction	ephrin receptor binding	SRC LYN CRK	4.13e-04	32	91	3	GO:0046875
GeneOntologyMolecularFunction	nerve growth factor binding	A2M FURIN	5.65e-04	8	91	2	GO:0048406
GeneOntologyMolecularFunction	actin filament binding	FLNA FLNB FLNC MYH14 CNN3 MYO16	6.02e-04	227	91	6	GO:0051015
GeneOntologyBiologicalProcess	cell morphogenesis	ARHGDIA FLNA FLNB MYH14 TNN SRC ADGRB3 PLXNA4 SYT1 SRCIN1 UNC93B1 ITGA4 MAPK8 LYN CDH7 MYO16 CRK	1.18e-05	1194	89	17	GO:0000902
GeneOntologyBiologicalProcess	positive regulation of podosome assembly	SRC MAPK8 MAPK9	2.15e-05	13	89	3	GO:0071803
GeneOntologyBiologicalProcess	regulation of podosome assembly	SRC MAPK8 MAPK9	5.05e-05	17	89	3	GO:0071801
GeneOntologyCellularComponent	neuronal cell body	FLNA DPP6 FLNB CYP17A1 TNN SRC SRCIN1 ITGA4 MAPK8 KCNB2 RRM1 MAPK9 CNN3 TTLL7	1.27e-05	835	90	14	GO:0043025
GeneOntologyCellularComponent	cell body	FLNA DPP6 FLNB CYP17A1 TNN SRC SRCIN1 ITGA4 MAPK8 KCNB2 RRM1 MAPK9 CNN3 TTLL7	4.13e-05	929	90	14	GO:0044297
GeneOntologyCellularComponent	actin cytoskeleton	FLNA FLNB FLNC MYH14 SRC SRCIN1 MAPK8 CNN3 MYO16 CRK	1.85e-04	576	90	10	GO:0015629
GeneOntologyCellularComponent	focal adhesion	FZD1 FLNA FLNB FLNC SRC SRCIN1 ITGA4 CNN3	5.42e-04	431	90	8	GO:0005925
GeneOntologyCellularComponent	cell-substrate junction	FZD1 FLNA FLNB FLNC SRC SRCIN1 ITGA4 CNN3	6.49e-04	443	90	8	GO:0030055
GeneOntologyCellularComponent	somatodendritic compartment	FLNA DPP6 FLNB CYP17A1 TNN SRC SRCIN1 ITGA4 MAPK8 KCNB2 RRM1 MAPK9 CNN3 TTLL7	7.40e-04	1228	90	14	GO:0036477
GeneOntologyCellularComponent	inner dynein arm	DNAH10 DNAH6	8.07e-04	10	90	2	GO:0036156
GeneOntologyCellularComponent	cerebellar climbing fiber to Purkinje cell synapse	ADGRB3 PLXNA4	9.83e-04	11	90	2	GO:0150053
HumanPheno	Accessory carpal bones	FLNA FLNB	2.13e-05	2	24	2	HP:0004232
HumanPheno	Bipartite calcaneus	FLNA FLNB	2.13e-05	2	24	2	HP:0008127
Domain	Ig_E-set	A2M ARHGDIA FLNA FLNB FLNC PLXNA4	1.25e-05	104	92	6	IPR014756
Domain	IG_FLMN	FLNA FLNB FLNC	1.35e-05	10	92	3	SM00557
Domain	Filamin	FLNA FLNB FLNC	1.85e-05	11	92	3	PF00630
Domain	FILAMIN_REPEAT	FLNA FLNB FLNC	1.85e-05	11	92	3	PS50194
Domain	Filamin/ABP280_rpt	FLNA FLNB FLNC	1.85e-05	11	92	3	IPR001298
Domain	Filamin/ABP280_repeat-like	FLNA FLNB FLNC	1.85e-05	11	92	3	IPR017868
Domain	Actinin_actin-bd_CS	FLNA FLNB FLNC	1.91e-04	23	92	3	IPR001589
Domain	ACTININ_2	FLNA FLNB FLNC	1.91e-04	23	92	3	PS00020
Domain	ACTININ_1	FLNA FLNB FLNC	1.91e-04	23	92	3	PS00019
Domain	MAPK_JNK	MAPK8 MAPK9	2.38e-04	5	92	2	IPR008351
Domain	CH	FLNA FLNB FLNC CNN3	2.97e-04	65	92	4	SM00033
Domain	CH	FLNA FLNB FLNC CNN3	3.94e-04	70	92	4	PF00307
Domain	-	FLNA FLNB FLNC CNN3	4.16e-04	71	92	4	1.10.418.10
Domain	CH	FLNA FLNB FLNC CNN3	4.63e-04	73	92	4	PS50021
Domain	CH-domain	FLNA FLNB FLNC CNN3	5.13e-04	75	92	4	IPR001715
Domain	MAP_kinase_CS	MAPK8 MAPK9	1.53e-03	12	92	2	IPR003527
Domain	MAPK	MAPK8 MAPK9	1.53e-03	12	92	2	PS01351
Domain	Dynein_heavy_chain_D4_dom	DNAH10 DNAH6	2.10e-03	14	92	2	IPR024317
Domain	Dynein_HC_stalk	DNAH10 DNAH6	2.10e-03	14	92	2	IPR024743
Domain	Dynein_heavy_dom-2	DNAH10 DNAH6	2.10e-03	14	92	2	IPR013602
Domain	DHC_N2	DNAH10 DNAH6	2.10e-03	14	92	2	PF08393
Domain	MT	DNAH10 DNAH6	2.10e-03	14	92	2	PF12777
Domain	AAA_8	DNAH10 DNAH6	2.10e-03	14	92	2	PF12780
Domain	ATPase_dyneun-rel_AAA	DNAH10 DNAH6	2.10e-03	14	92	2	IPR011704
Domain	AAA_5	DNAH10 DNAH6	2.10e-03	14	92	2	PF07728
Domain	DHC_fam	DNAH10 DNAH6	2.42e-03	15	92	2	IPR026983
Domain	Dynein_heavy_dom	DNAH10 DNAH6	2.42e-03	15	92	2	IPR004273
Domain	Dynein_heavy	DNAH10 DNAH6	2.42e-03	15	92	2	PF03028
Domain	Sulfatase	ARSH PIGG	3.49e-03	18	92	2	PF00884
Domain	Sulfatase_N	ARSH PIGG	3.49e-03	18	92	2	IPR000917
Domain	TSP_1	ADAMTS2 ADGRB3 ADAMTSL2	3.71e-03	63	92	3	PF00090
Domain	PLAC	ADAMTS2 ADAMTSL2	3.89e-03	19	92	2	PS50900
Domain	PLAC	ADAMTS2 ADAMTSL2	3.89e-03	19	92	2	IPR010909
Domain	C2	SYT15 SYT15B SYT6 SYT1	4.01e-03	131	92	4	PF00168
Domain	TSP1	ADAMTS2 ADGRB3 ADAMTSL2	4.05e-03	65	92	3	SM00209
Domain	TSP1_rpt	ADAMTS2 ADGRB3 ADAMTSL2	4.05e-03	65	92	3	IPR000884
Domain	TSP1	ADAMTS2 ADGRB3 ADAMTSL2	4.05e-03	65	92	3	PS50092
Domain	Synaptotagmin	SYT6 SYT1	4.30e-03	20	92	2	IPR001565
Domain	C2	SYT15 SYT15B SYT6 SYT1	4.70e-03	137	92	4	SM00239
Domain	GPCR_3	GPRC5C GPRC6A	4.74e-03	21	92	2	IPR000337
Pathway	WP_FOCAL_ADHESION	FLNA FLNB FLNC VWF TNN SRC ITGA4 MAPK8 MAPK9 CRK	6.28e-08	199	72	10	M39402
Pathway	KEGG_FOCAL_ADHESION	FLNA FLNB FLNC VWF TNN SRC ITGA4 MAPK8 MAPK9 CRK	6.28e-08	199	72	10	M7253
Pathway	WP_THYMIC_STROMAL_LYMPHOPOIETIN_TSLP_SIGNALING	SRC MAPK8 MAPK9 LYN GAB2	3.92e-06	47	72	5	M39380
Pathway	WP_FOCAL_ADHESION	FLNA VWF TNN SRC ITGA4 MAPK8 MAPK9 CRK	4.79e-06	187	72	8	MM15913
Pathway	WP_RANKLRANK_SIGNALING	SRC MAPK8 MAPK9 LYN GAB2	8.61e-06	55	72	5	M39667
Pathway	WP_IL3_SIGNALING_PATHWAY	SRC MAPK8 MAPK9 LYN CRK GAB2	1.17e-05	100	72	6	MM15879
Pathway	WP_KIT_RECEPTOR_SIGNALING	SRC MAPK8 LYN CRK GAB2	1.22e-05	59	72	5	M39350
Pathway	WP_NPHP1_DELETION_SYNDROME	FLNA FLNB FLNC	2.05e-05	11	72	3	M48099
Pathway	REACTOME_GP1B_IX_V_ACTIVATION_SIGNALLING	FLNA VWF SRC	2.72e-05	12	72	3	MM15093
Pathway	REACTOME_GP1B_IX_V_ACTIVATION_SIGNALLING	FLNA VWF SRC	2.72e-05	12	72	3	M27352
Pathway	WP_PROLACTIN_SIGNALING	FLNA SRC MAPK8 MAPK9 GAB2	4.21e-05	76	72	5	M39601
Pathway	PID_TCR_JNK_PATHWAY	MAP3K8 MAPK8 CRK	4.47e-05	14	72	3	M190
Pathway	REACTOME_EXTRACELLULAR_MATRIX_ORGANIZATION	A2M COL12A1 VWF ADAMTS2 LOXL2 TNN FURIN ITGA4	4.91e-05	258	72	8	MM14572
Pathway	PID_PDGFRB_PATHWAY	ARHGDIA SRC MAPK8 MAPK9 LYN CRK	4.98e-05	129	72	6	M186
Pathway	REACTOME_P130CAS_LINKAGE_TO_MAPK_SIGNALING_FOR_INTEGRINS	VWF SRC CRK	5.56e-05	15	72	3	M12101
Pathway	REACTOME_P130CAS_LINKAGE_TO_MAPK_SIGNALING_FOR_INTEGRINS	VWF SRC CRK	5.56e-05	15	72	3	MM14961
Pathway	KEGG_MAPK_SIGNALING_PATHWAY	FLNA FLNB FLNC MAP3K8 RPS6KA6 MAPK8 MAPK9 CRK	6.26e-05	267	72	8	M10792
Pathway	WP_IL2_SIGNALING_PATHWAY	MAPK8 MAPK9 LYN CRK GAB2	8.06e-05	87	72	5	MM15915
Pathway	WP_CANONICAL_AND_NONCANONICAL_TGFB_SIGNALING	LOXL2 MAPK8 MAPK9	8.25e-05	17	72	3	M39686
Pathway	WP_TCELL_RECEPTOR_SIGNALING	MAP3K8 MAPK8 MAPK9 CRK GAB2	9.47e-05	90	72	5	M39725
Pathway	WP_IL3_SIGNALING	SRC MAPK8 LYN GAB2	1.11e-04	49	72	4	M39722
Pathway	WP_B_CELL_RECEPTOR_SIGNALING	MAPK8 MAPK9 LYN CRK GAB2	1.35e-04	97	72	5	M39323
Pathway	REACTOME_EXTRACELLULAR_MATRIX_ORGANIZATION	A2M COL12A1 VWF ADAMTS2 LOXL2 TNN FURIN ITGA4	1.41e-04	300	72	8	M610
Pathway	PID_RAC1_PATHWAY	ARHGDIA MAPK8 MAPK9 CRK	1.63e-04	54	72	4	M278
Pathway	PID_FAK_PATHWAY	SRC MAPK8 MAPK9 CRK	2.30e-04	59	72	4	M281
Pathway	WP_MAPK_SIGNALING	FLNA FLNB FLNC MAP3K8 MAPK8 MAPK9 CRK	2.54e-04	246	72	7	M39597
Pathway	KEGG_MEDICUS_PATHOGEN_HIV_VPR_TAT_TO_TNF_JNK_SIGNALING_PATHWAY	MAPK8 MAPK9	2.55e-04	5	72	2	M47570
Pathway	KEGG_MEDICUS_ENV_FACTOR_PARAQUAT_TO_FAS_JNK_SIGNALING_PATHWAY	MAPK8 MAPK9	2.55e-04	5	72	2	M49021
Pathway	KEGG_MEDICUS_PATHOGEN_HTLV_1_TAX_TO_TNF_JNK_SIGNALING_PATHWAY	MAPK8 MAPK9	2.55e-04	5	72	2	M49005
Pathway	REACTOME_INTEGRIN_SIGNALING	VWF SRC CRK	3.42e-04	27	72	3	M760
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_HTT_TO_TNF_JNK_SIGNALING_PATHWAY	MAPK8 MAPK9	3.81e-04	6	72	2	M47680
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_ABETA_TO_IRE1A_JNK_SIGNALING_PATHWAY	MAPK8 MAPK9	3.81e-04	6	72	2	M47698
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_INACTIVATED_DJ1_TO_FAS_JNK_SIGNALING_PATWHAY	MAPK8 MAPK9	3.81e-04	6	72	2	M47712
Pathway	WP_NANOPARTICLEMEDIATED_ACTIVATION_OF_RECEPTOR_SIGNALING	SRC MAPK8 MAPK9	3.82e-04	28	72	3	M39572
Pathway	REACTOME_INTEGRIN_SIGNALING	VWF SRC CRK	3.82e-04	28	72	3	MM14958
Pathway	WP_RAC1PAK1P38MMP2_PATHWAY	SRC MAPK8 MAPK9 CRK	3.98e-04	68	72	4	M39456
Pathway	KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION	SRC MAPK8 MAPK9 LYN	3.98e-04	68	72	4	M16848
Pathway	PID_P75_NTR_PATHWAY	ARHGDIA FURIN MAPK8 MAPK9	3.98e-04	68	72	4	M153
Pathway	REACTOME_EPHA_MEDIATED_GROWTH_CONE_COLLAPSE	MYH14 SRC LYN	4.24e-04	29	72	3	M27309
Pathway	PID_CDC42_PATHWAY	ARHGDIA SRC MAPK8 MAPK9	4.45e-04	70	72	4	M81
Pathway	KEGG_NEUROTROPHIN_SIGNALING_PATHWAY	ARHGDIA RPS6KA6 MAPK8 MAPK9 CRK	4.57e-04	126	72	5	M16763
Pathway	PID_EPHRINB_REV_PATHWAY	SRC MAPK8 LYN	4.70e-04	30	72	3	M257
Pathway	KEGG_MEDICUS_REFERENCE_ITGA_B_FAK_RAC_SIGNALING_PATHWAY	SRC ITGA4 CRK	4.70e-04	30	72	3	M47718
Pathway	REACTOME_SIGNALING_BY_CSF1_M_CSF_IN_MYELOID_CELLS	SRC LYN GAB2	5.18e-04	31	72	3	M46423
Pathway	KEGG_MEDICUS_REFERENCE_IRE1A_JNK_SIGNALING_PATHWAY	MAPK8 MAPK9	5.31e-04	7	72	2	M47697
Pathway	REACTOME_DEFECTIVE_FACTOR_VIII_CAUSES_HEMOPHILIA_A	TPST2 VWF	5.31e-04	7	72	2	M39000
Pathway	KEGG_MEDICUS_REFERENCE_FAS_JNK_SIGNALING_PATHWAY	MAPK8 MAPK9	5.31e-04	7	72	2	M47711
Pathway	WP_ANGIOPOIETINLIKE_PROTEIN_8_REGULATORY_PATHWAY	MAP3K8 RPS6KA6 MAPK8 MAPK9 CRK	5.65e-04	132	72	5	M39338
Pathway	PID_WNT_NONCANONICAL_PATHWAY	FLNA MAPK8 MAPK9	5.70e-04	32	72	3	M23
Pathway	PID_INTEGRIN_A4B1_PATHWAY	SRC ITGA4 CRK	6.24e-04	33	72	3	M277
Pathway	REACTOME_CD28_CO_STIMULATION	MAP3K8 SRC LYN	6.24e-04	33	72	3	M11725
Pathway	WP_HEPATOCYTE_GROWTH_FACTOR_RECEPTOR_SIGNALING	SRC MAPK8 CRK	6.82e-04	34	72	3	M39383
Pathway	WP_13Q1212_COPY_NUMBER_VARIATION	FLNC MAPK8 MAPK9	6.82e-04	34	72	3	M48103
Pathway	PID_EPHA_FWDPATHWAY	SRC LYN CRK	6.82e-04	34	72	3	M177
Pathway	SIG_CD40PATHWAYMAP	SYT1 MAPK8 MAPK9	6.82e-04	34	72	3	M12705
Pathway	REACTOME_CD28_CO_STIMULATION	MAP3K8 SRC LYN	6.82e-04	34	72	3	MM14992
Pathway	PID_MET_PATHWAY	SRC MAPK8 CRK GAB2	7.04e-04	79	72	4	M48
Pathway	KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY	MAPK8 MAPK9 LYN GAB2	7.04e-04	79	72	4	M11816
Pathway	KEGG_MEDICUS_ENV_FACTOR_METALS_TO_JNK_SIGNALING_PATHWAY	MAPK8 MAPK9	7.06e-04	8	72	2	M47814
Pathway	WP_WNT_SIGNALING_IN_KIDNEY_DISEASE	FZD1 MAPK8 MAPK9	8.08e-04	36	72	3	M39699
Pathway	PID_FAS_PATHWAY	SRC MAPK8 MAPK9	9.48e-04	38	72	3	M94
Pathway	REACTOME_PLATELET_AGGREGATION_PLUG_FORMATION	VWF SRC CRK	9.48e-04	38	72	3	MM15456
Pathway	KEGG_ERBB_SIGNALING_PATHWAY	SRC MAPK8 MAPK9 CRK	1.01e-03	87	72	4	M12467
Pathway	REACTOME_PLATELET_AGGREGATION_PLUG_FORMATION	VWF SRC CRK	1.02e-03	39	72	3	M10735
Pathway	PID_RET_PATHWAY	SRC MAPK8 CRK	1.02e-03	39	72	3	M82
Pathway	REACTOME_ACTIVATION_OF_THE_AP_1_FAMILY_OF_TRANSCRIPTION_FACTORS	MAPK8 MAPK9	1.13e-03	10	72	2	MM15135
Pathway	REACTOME_ACTIVATION_OF_THE_AP_1_FAMILY_OF_TRANSCRIPTION_FACTORS	MAPK8 MAPK9	1.13e-03	10	72	2	M13962
Pathway	WP_SARSCOV2_AND_COVID19_PATHWAY	FURIN SCARB1	1.13e-03	10	72	2	M40050
Pathway	WP_ERBB_SIGNALING	SRC MAPK8 MAPK9 CRK	1.25e-03	92	72	4	M39715
Pathway	WP_MAPK_SIGNALING_PATHWAY	FLNA MAP3K8 MAPK8 MAPK9 CRK	1.34e-03	160	72	5	MM15990
Pathway	WP_INSULIN_SIGNALING	MAP3K8 RPS6KA6 MAPK8 MAPK9 CRK	1.34e-03	160	72	5	MM15956
Pathway	WP_INSULIN_SIGNALING	MAP3K8 RPS6KA6 MAPK8 MAPK9 CRK	1.34e-03	160	72	5	M39482
Pathway	REACTOME_SIGNALING_BY_SCF_KIT	SRC LYN GAB2	1.36e-03	43	72	3	M508
Pathway	WP_EGFEGFR_SIGNALING	SRC MAPK8 MAPK9 CRK GAB2	1.42e-03	162	72	5	M39334
Pathway	PID_ERBB2_ERBB3_PATHWAY	SRC MAPK8 MAPK9	1.46e-03	44	72	3	M175
Pathway	WP_WNT_SIGNALING_IN_KIDNEY_DISEASE	FZD1 MAPK8 MAPK9	1.46e-03	44	72	3	MM15878
Pathway	REACTOME_PECAM1_INTERACTIONS	SRC LYN	1.64e-03	12	72	2	MM14835
Pathway	REACTOME_PLATELET_ADHESION_TO_EXPOSED_COLLAGEN	VWF LYN	1.64e-03	12	72	2	MM15452
Pathway	KEGG_MEDICUS_REFERENCE_MLK_JNK_SIGNALING_PATHWAY	MAPK8 MAPK9	1.64e-03	12	72	2	M47929
Pathway	REACTOME_PECAM1_INTERACTIONS	SRC LYN	1.64e-03	12	72	2	M11773
Pathway	WP_ERBB_SIGNALING_PATHWAY	SRC MAPK8 CRK	1.66e-03	46	72	3	MM15950
Pathway	PID_CXCR4_PATHWAY	SRC ITGA4 LYN CRK	1.70e-03	100	72	4	M124
Pathway	WP_MECHANOREGULATION_AND_PATHOLOGY_OF_YAPTAZ_VIA_HIPPO_AND_NONHIPPO_MECHANISMS	SRC MAPK8 MAPK9	1.76e-03	47	72	3	M39829
Pathway	REACTOME_INTERLEUKIN_3_INTERLEUKIN_5_AND_GM_CSF_SIGNALING	LYN CRK GAB2	1.87e-03	48	72	3	M914
Pathway	KEGG_MEDICUS_REFERENCE_EGF_EGFR_RAS_JNK_SIGNALING_PATHWAY	MAPK8 MAPK9	1.93e-03	13	72	2	M47594
Pathway	REACTOME_REGULATION_OF_KIT_SIGNALING	SRC LYN	1.93e-03	13	72	2	MM14565
Pathway	REACTOME_PLATELET_ACTIVATION_SIGNALING_AND_AGGREGATION	A2M FLNA VWF SRC LYN CRK	1.98e-03	257	72	6	MM15454
Pathway	WP_INTERLEUKIN1_IL1_STRUCTURAL_PATHWAY	MAP3K8 MAPK8 MAPK9	1.99e-03	49	72	3	M39543
Pathway	REACTOME_PLATELET_ACTIVATION_SIGNALING_AND_AGGREGATION	A2M FLNA VWF SRC LYN CRK	2.14e-03	261	72	6	M1077
Pathway	WP_MACROPHAGESTIMULATING_PROTEIN_MSP_SIGNALING	FZD1 SRC MAPK8 MAPK9	2.25e-03	108	72	4	M48078
Pathway	PID_PTP1B_PATHWAY	SRC LYN CRK	2.36e-03	52	72	3	M50
Pathway	PID_NFAT_3PATHWAY	MAP3K8 MAPK8 MAPK9	2.49e-03	53	72	3	M113
Pathway	REACTOME_GRB2_SOS_PROVIDES_LINKAGE_TO_MAPK_SIGNALING_FOR_INTEGRINS	VWF SRC	2.59e-03	15	72	2	M1262
Pathway	REACTOME_GRB2_SOS_PROVIDES_LINKAGE_TO_MAPK_SIGNALING_FOR_INTEGRINS	VWF SRC	2.59e-03	15	72	2	MM14959
Pathway	PID_IL2_1PATHWAY	MAPK8 MAPK9 GAB2	2.77e-03	55	72	3	M122
Pathway	WP_GASTRIN_SIGNALING	SRC MAPK8 MAPK9 CRK	2.82e-03	115	72	4	M39866
Pathway	KEGG_MEDICUS_REFERENCE_TNF_JNK_SIGNALING_PATHWAY	MAPK8 MAPK9	2.95e-03	16	72	2	M47569
Pathway	REACTOME_PLATELET_ADHESION_TO_EXPOSED_COLLAGEN	VWF LYN	2.95e-03	16	72	2	M9450
Pathway	REACTOME_DEFECTS_OF_CONTACT_ACTIVATION_SYSTEM_CAS_AND_KALLIKREIN_KININ_SYSTEM_KKS	TPST2 VWF	2.95e-03	16	72	2	M38996
Pathway	REACTOME_REGULATION_OF_KIT_SIGNALING	SRC LYN	2.95e-03	16	72	2	M537
Pubmed	Filamin A and Filamin B are co-expressed within neurons during periods of neuronal migration and can physically interact.	FLNA FLNB FLNC	1.79e-08	3	92	3	12393796
Pubmed	Cytoskeletal protein ABP-280 directs the intracellular trafficking of furin and modulates proprotein processing in the endocytic pathway.	FLNA FLNC FURIN	1.79e-08	3	92	3	9412467
Pubmed	Genomic structure and fine mapping of the two human filamin gene paralogues FLNB and FLNC and comparative analysis of the filamin gene family.	FLNA FLNB FLNC	1.79e-08	3	92	3	11153914
Pubmed	Filamins as integrators of cell mechanics and signalling.	FLNA FLNB FLNC	1.79e-08	3	92	3	11252955
Pubmed	The SH2-containing inositol polyphosphate 5-phosphatase, SHIP-2, binds filamin and regulates submembraneous actin.	FLNA FLNB FLNC	7.15e-08	4	92	3	11739414
Pubmed	Structural interaction and functional regulation of polycystin-2 by filamin.	FLNA FLNB FLNC	7.15e-08	4	92	3	22802962
Pubmed	Phosphorylation of moesin by Jun N-terminal kinase is important for podosome rosette formation in Src-transformed fibroblasts.	SRC MAPK8 MAPK9	7.15e-08	4	92	3	24127566
Pubmed	Nephrocystin-conserved domains involved in targeting to epithelial cell-cell junctions, interaction with filamins, and establishing cell polarity.	FLNA FLNB FLNC	1.78e-07	5	92	3	12006559
Pubmed	Interaction between von Willebrand factor and glycoprotein Ib activates Src kinase in human platelets: role of phosphoinositide 3-kinase.	VWF SRC LYN	1.78e-07	5	92	3	12393736
Pubmed	Filamin B deficiency in mice results in skeletal malformations and impaired microvascular development.	FLNA FLNB FLNC	1.78e-07	5	92	3	17360453
Pubmed	HIV infection of T cells: actin-in and actin-out.	FLNA FLNB FLNC	1.78e-07	5	92	3	19366992
Pubmed	ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.	PDIA4 TPST2 COL12A1 MGAT5 DNAJC16 LOXL2 GLCE FURIN SCARB1 UGGT2 CPD UNC93B1 PIGG RRM1 HIF1AN	5.90e-07	1201	92	15	35696571
Pubmed	Role of Fc receptor gamma-chain in platelet glycoprotein Ib-mediated signaling.	VWF SRC LYN	6.22e-07	7	92	3	11389024
Pubmed	ASAP1, a phospholipid-dependent arf GTPase-activating protein that associates with and is phosphorylated by Src.	SRC LYN CRK	6.22e-07	7	92	3	9819391
Pubmed	The Z-disc proteins myotilin and FATZ-1 interact with each other and are connected to the sarcolemma via muscle-specific filamins.	FLNA FLNB FLNC	6.22e-07	7	92	3	16076904
Pubmed	The proto-oncogene c-Cbl is a positive regulator of Met-induced MAP kinase activation: a role for the adaptor protein Crk.	SRC MAPK8 CRK	6.22e-07	7	92	3	10962563
Pubmed	c-Cbl is inducibly tyrosine-phosphorylated by epidermal growth factor stimulation in fibroblasts, and constitutively tyrosine-phosphorylated and associated with v-Src in v-src-transformed fibroblasts.	SRC LYN CRK	9.94e-07	8	92	3	8635998
Pubmed	MEKK4 signaling regulates filamin expression and neuronal migration.	FLNA FLNB FLNC	9.94e-07	8	92	3	17145501
Pubmed	Gab2 is involved in differential phosphoinositide 3-kinase signaling by two splice forms of c-Kit.	SRC LYN GAB2	1.49e-06	9	92	3	18697750
Pubmed	Different splice variants of filamin-B affect myogenesis, subcellular distribution, and determine binding to integrin [beta] subunits.	FLNA FLNB FLNC	1.49e-06	9	92	3	11807098
Pubmed	The docking protein Cas links tyrosine phosphorylation signaling to elongation of cerebellar granule cell axons.	SRC MAPK8 CRK	2.12e-06	10	92	3	16687575
Pubmed	Mouse endothelial OTUD1 promotes angiotensin II-induced vascular remodeling by deubiquitinating SMAD3.	FLNA FLNB FLNC	2.91e-06	11	92	3	36579465
Pubmed	GC-GAP, a Rho family GTPase-activating protein that interacts with signaling adapters Gab1 and Gab2.	SRC CRK GAB2	5.03e-06	13	92	3	12819203
Pubmed	A human MAP kinase interactome.	ARHGDIA FLNA FLNC VWF COBLL1 SRC NUP98 MAPK9 GAB2	5.88e-06	486	92	9	20936779
Pubmed	PTK7 regulates myosin II activity to orient planar polarity in the mammalian auditory epithelium.	MYH14 MAPK8 MAPK9	6.38e-06	14	92	3	22560610
Pubmed	C-Jun N-terminal kinase (JNK) isoforms play differing roles in otitis media.	MAPK8 MAPK9	6.92e-06	2	92	2	25311344
Pubmed	Genetic inhibition or activation of JNK1/2 protects the myocardium from ischemia-reperfusion-induced cell death in vivo.	MAPK8 MAPK9	6.92e-06	2	92	2	16043490
Pubmed	Combined Activities of JNK1 and JNK2 in Hepatocytes Protect Against Toxic Liver Injury.	MAPK8 MAPK9	6.92e-06	2	92	2	26708719
Pubmed	Preferred sequence requirements for cleavage of pro-von Willebrand factor by propeptide-processing enzymes.	VWF FURIN	6.92e-06	2	92	2	1571548
Pubmed	Functional in vivo interactions between JNK1 and JNK2 isoforms in obesity and insulin resistance.	MAPK8 MAPK9	6.92e-06	2	92	2	16818881
Pubmed	The Src tyrosine kinase pathway regulates thecal CYP17 expression and androstenedione secretion.	CYP17A1 SRC	6.92e-06	2	92	2	18642057
Pubmed	Suppression of inflammatory cytokine production by carbon monoxide involves the JNK pathway and AP-1.	MAPK8 MAPK9	6.92e-06	2	92	2	12857751
Pubmed	JNK1, but not JNK2, is required in two mechanistically distinct models of inflammatory arthritis.	MAPK8 MAPK9	6.92e-06	2	92	2	21839715
Pubmed	Prevention of steatosis by hepatic JNK1.	MAPK8 MAPK9	6.92e-06	2	92	2	19945406
Pubmed	Hypothermia attenuates ischemia/reperfusion-induced endothelial cell apoptosis via alterations in apoptotic pathways and JNK signaling.	MAPK8 MAPK9	6.92e-06	2	92	2	19596001
Pubmed	Increased JNK in males compared with females in a rodent model of abdominal aortic aneurysm.	MAPK8 MAPK9	6.92e-06	2	92	2	22316675
Pubmed	c-Jun N-terminal kinase is required for metalloproteinase expression and joint destruction in inflammatory arthritis.	MAPK8 MAPK9	6.92e-06	2	92	2	11435459
Pubmed	The JNKs differentially regulate RNA polymerase III transcription by coordinately modulating the expression of all TFIIIB subunits.	MAPK8 MAPK9	6.92e-06	2	92	2	19620725
Pubmed	Disruption of the Flnb gene in mice phenocopies the human disease spondylocarpotarsal synostosis syndrome.	FLNA FLNB	6.92e-06	2	92	2	17635842
Pubmed	JNK inhibition reduces apoptosis and neovascularization in a murine model of age-related macular degeneration.	MAPK8 MAPK9	6.92e-06	2	92	2	23341606
Pubmed	Identification of predicted human outer dynein arm genes: candidates for primary ciliary dyskinesia genes.	DNAH10 DNAH6	6.92e-06	2	92	2	15937072
Pubmed	Defective neural tube morphogenesis and altered apoptosis in the absence of both JNK1 and JNK2.	MAPK8 MAPK9	6.92e-06	2	92	2	10559486
Pubmed	JNK regulates muscle remodeling via myostatin/SMAD inhibition.	MAPK8 MAPK9	6.92e-06	2	92	2	30072727
Pubmed	Inhibition of JNK reduces G2/M transit independent of p53, leading to endoreduplication, decreased proliferation, and apoptosis in breast cancer cells.	MAPK8 MAPK9	6.92e-06	2	92	2	14724588
Pubmed	A novel human actin-binding protein homologue that binds to platelet glycoprotein Ibalpha.	FLNB FLNC	6.92e-06	2	92	2	9694715
Pubmed	Coordination of JNK1 and JNK2 is critical for GADD45alpha induction and its mediated cell apoptosis in arsenite responses.	MAPK8 MAPK9	6.92e-06	2	92	2	16973625
Pubmed	Propolypeptide of von Willebrand factor is a novel ligand for very late antigen-4 integrin.	VWF ITGA4	6.92e-06	2	92	2	9079671
Pubmed	c-Jun N-terminal kinase 2 suppresses pancreatic cancer growth and invasion and is opposed by c-Jun N-terminal kinase 1.	MAPK8 MAPK9	6.92e-06	2	92	2	33526844
Pubmed	Mapping of two genes encoding isoforms of the actin binding protein ABP-280, a dystrophin like protein, to Xq28 and to chromosome 7.	FLNA FLNC	6.92e-06	2	92	2	7689010
Pubmed	Rescue of osteoclast function by transgenic expression of kinase-deficient Src in src-/- mutant mice.	SRC LYN	6.92e-06	2	92	2	9353253
Pubmed	Decreased expression of phosphorylated JNK in breast infiltrating ductal carcinoma is associated with a better overall survival.	MAPK8 MAPK9	6.92e-06	2	92	2	16381010
Pubmed	Gab2 plays a carcinogenic role in ovarian cancer by regulating CrkII.	CRK GAB2	6.92e-06	2	92	2	37085900
Pubmed	Protective role of c-Jun N-terminal kinase 2 in acetaminophen-induced liver injury.	MAPK8 MAPK9	6.92e-06	2	92	2	18586006
Pubmed	JNK/SAPK Signaling Is Essential for Efficient Reprogramming of Human Fibroblasts to Induced Pluripotent Stem Cells.	MAPK8 MAPK9	6.92e-06	2	92	2	26867034
Pubmed	Filamin depletion blocks endoplasmic spreading and destabilizes force-bearing adhesions.	FLNA FLNB	6.92e-06	2	92	2	21325628
Pubmed	Filamin B serves as a molecular scaffold for type I interferon-induced c-Jun NH2-terminal kinase signaling pathway.	FLNB MAPK8	6.92e-06	2	92	2	18815275
Pubmed	Saturated fatty acids induce c-Src clustering within membrane subdomains, leading to JNK activation.	SRC MAPK8	6.92e-06	2	92	2	21962514
Pubmed	Jun N-terminal kinase 1 regulates epithelial-to-mesenchymal transition induced by TGF-beta1.	MAPK8 MAPK9	6.92e-06	2	92	2	18334556
Pubmed	Filamin isogene expression during mouse myogenesis.	FLNA FLNC	6.92e-06	2	92	2	10679933
Pubmed	A pathogenic role for c-Jun amino-terminal kinase signaling in renal fibrosis and tubular cell apoptosis.	MAPK8 MAPK9	6.92e-06	2	92	2	17202416
Pubmed	The role of JNK in the development of hepatocellular carcinoma.	MAPK8 MAPK9	6.92e-06	2	92	2	21406557
Pubmed	JNK1/2 regulates ER-mitochondrial Ca2+ cross-talk during IL-1β-mediated cell death in RINm5F and human primary β-cells.	MAPK8 MAPK9	6.92e-06	2	92	2	23615449
Pubmed	Signal transduction by the JNK group of MAP kinases.	MAPK8 MAPK9	6.92e-06	2	92	2	11057897
Pubmed	Silencing Jnk1 and Jnk2 accelerates basal lipolysis and promotes fatty acid re-esterification in mouse adipocytes.	MAPK8 MAPK9	6.92e-06	2	92	2	18528680
Pubmed	Role of Src-family kinases in formation of the cortical actin cap at the dorsal cell surface.	SRC LYN	6.92e-06	2	92	2	18457834
Pubmed	A novel structural unit in the N-terminal region of filamins.	FLNA FLNC	6.92e-06	2	92	2	24469451
Pubmed	JNK-dependent Stat3 phosphorylation contributes to Akt activation in response to arsenic exposure.	MAPK8 MAPK9	6.92e-06	2	92	2	22696236
Pubmed	Ablation of the spindle assembly checkpoint by a compound targeting Mps1.	MAPK8 MAPK9	6.92e-06	2	92	2	16113653
Pubmed	c-Jun N-terminal kinase 1 is deleterious to the function and survival of murine pancreatic islets.	MAPK8 MAPK9	6.92e-06	2	92	2	18853132
Pubmed	Ultrafine particles from diesel engines induce vascular oxidative stress via JNK activation.	MAPK8 MAPK9	6.92e-06	2	92	2	19154785
Pubmed	Role of the MAPK/cJun NH2-terminal kinase signaling pathway in starvation-induced autophagy.	MAPK8 MAPK9	6.92e-06	2	92	2	29950132
Pubmed	Specific role of JNK in the maintenance of the tumor-initiating capacity of A549 human non-small cell lung cancer cells.	MAPK8 MAPK9	6.92e-06	2	92	2	23912840
Pubmed	JNK is required for maintaining the tumor-initiating cell-like properties of acquired chemoresistant human cancer cells.	MAPK8 MAPK9	6.92e-06	2	92	2	26235742
Pubmed	C-Jun NH(2)-terminal kinase mediates proliferation and tumor growth of human prostate carcinoma.	MAPK8 MAPK9	6.92e-06	2	92	2	12538493
Pubmed	Inhibition of Jun NH2-terminal kinases suppresses the growth of experimental head and neck squamous cell carcinoma.	MAPK8 MAPK9	6.92e-06	2	92	2	17908987
Pubmed	c-Jun N-terminal kinase 1/2 activation by tumor necrosis factor-alpha induces insulin resistance in human visceral but not subcutaneous adipocytes: reversal by liver X receptor agonists.	MAPK8 MAPK9	6.92e-06	2	92	2	19567513
Pubmed	Expression of a human proprotein processing enzyme: correct cleavage of the von Willebrand factor precursor at a paired basic amino acid site.	VWF FURIN	6.92e-06	2	92	2	2251280
Pubmed	Defective antiviral CD8 T-cell response and viral clearance in the absence of c-Jun N-terminal kinases.	MAPK8 MAPK9	6.92e-06	2	92	2	24673683
Pubmed	[Sodium butyrate do not induce the program of premature senescence in transformants with JNK1,2 knockout].	MAPK8 MAPK9	6.92e-06	2	92	2	19140343
Pubmed	Modulation of the response of prostate cancer cell lines to cisplatin treatment using small interfering RNA.	MAPK8 MAPK9	6.92e-06	2	92	2	23900581
Pubmed	Inhibition of c-Jun N-terminal kinase attenuates low shear stress-induced atherogenesis in apolipoprotein E-deficient mice.	MAPK8 MAPK9	6.92e-06	2	92	2	21629969
Pubmed	c-Jun N-terminal protein kinase 1 (JNK1), but not JNK2, is essential for tumor necrosis factor alpha-induced c-Jun kinase activation and apoptosis.	MAPK8 MAPK9	6.92e-06	2	92	2	15572687
Pubmed	Analysis of DPP6 and FGGY as candidate genes for amyotrophic lateral sclerosis.	DPP6 FGGY	6.92e-06	2	92	2	20001489
Pubmed	Hepatotoxicity mediated by pyrazole (cytochrome P450 2E1) plus tumor necrosis factor alpha treatment occurs in c-Jun N-terminal kinase 2-/- but not in c-Jun N-terminal kinase 1-/- mice.	MAPK8 MAPK9	6.92e-06	2	92	2	21748763
Pubmed	Purinergic (ATP) signaling stimulates JNK1 but not JNK2 MAPK in osteoblast-like cells: contribution of intracellular Ca2+ release, stress activated and L-voltage-dependent calcium influx, PKC and Src kinases.	MAPK8 MAPK9	6.92e-06	2	92	2	18625195
Pubmed	Tumor necrosis factor-induced toxic liver injury results from JNK2-dependent activation of caspase-8 and the mitochondrial death pathway.	MAPK8 MAPK9	6.92e-06	2	92	2	16571730
Pubmed	The limits of promiscuity: isoform-specific dimerization of filamins.	FLNB FLNC	6.92e-06	2	92	2	12525170
Pubmed	c-Jun N-terminal kinase 2 promotes enterocyte survival and goblet cell differentiation in the inflamed intestine.	MAPK8 MAPK9	6.92e-06	2	92	2	28098247
Pubmed	c-Jun N-terminal kinase is upregulated in patients with hypospadias.	MAPK8 MAPK9	6.92e-06	2	92	2	23273084
Pubmed	An initial phase of JNK activation inhibits cell death early in the endoplasmic reticulum stress response.	MAPK8 MAPK9	6.92e-06	2	92	2	27122189
Pubmed	Structural and functional aspects of filamins.	FLNA FLNB	6.92e-06	2	92	2	11336782
Pubmed	JNK2 up-regulates hypoxia-inducible factors and contributes to hypoxia-induced erythropoiesis and pulmonary hypertension.	MAPK8 MAPK9	6.92e-06	2	92	2	29118187
Pubmed	CRK adaptor protein expression is required for efficient replication of avian influenza A viruses and controls JNK-mediated apoptotic responses.	MAPK8 CRK	6.92e-06	2	92	2	20088952
Pubmed	The variants at FLNA and FLNB contribute to the susceptibility of hypertension and stroke with differentially expressed mRNA.	FLNA FLNB	6.92e-06	2	92	2	33649519
Pubmed	c-Jun N-terminal kinase activity is required for efficient respiratory syncytial virus production.	MAPK8 MAPK9	6.92e-06	2	92	2	28062184
Pubmed	c-Jun NH(2)-terminal kinase (JNK)1 and JNK2 have distinct roles in CD8(+) T cell activation.	MAPK8 MAPK9	6.92e-06	2	92	2	11927626
Pubmed	c-Jun NH(2)-terminal kinase (JNK)1 and JNK2 signaling pathways have divergent roles in CD8(+) T cell-mediated antiviral immunity.	MAPK8 MAPK9	6.92e-06	2	92	2	11927625
Pubmed	Efficient keratinocyte differentiation strictly depends on JNK-induced soluble factors in fibroblasts.	MAPK8 MAPK9	6.92e-06	2	92	2	24335928
Pubmed	Inhibition of cell proliferation and cell cycle progression by specific inhibition of basal JNK activity: evidence that mitotic Bcl-2 phosphorylation is JNK-independent.	MAPK8 MAPK9	6.92e-06	2	92	2	14704147
Pubmed	Differential roles of JNK in ConA/GalN and ConA-induced liver injury in mice.	MAPK8 MAPK9	6.92e-06	2	92	2	18772342
Interaction	GP1BA interactions	FLNA FLNB VWF SRC LYN	1.25e-07	27	91	5	int:GP1BA
Interaction	C1orf54 interactions	TPST2 MGAT5 ADAMTS2 LOXL2 GLCE SCARB1 UGGT2 ITGA4	8.91e-07	167	91	8	int:C1orf54
Interaction	MAP2K4 interactions	FLNA FLNB FLNC MAP3K8 MAPK8 MAPK9	1.77e-06	81	91	6	int:MAP2K4
Interaction	LYZL2 interactions	PDIA4 COL12A1 MGAT5 ADAMTS2 LOXL2 UGGT2	2.36e-06	85	91	6	int:LYZL2
Interaction	ADAMTS4 interactions	PDIA4 ADAMTS2 LOXL2 FURIN UGGT2	1.85e-05	72	91	5	int:ADAMTS4
Interaction	NRXN1 interactions	FLNB SYT6 SYT1 SRCIN1 KCNB2 MYO16	2.39e-05	127	91	6	int:NRXN1
Interaction	MICAL1 interactions	SLC25A41 TAS2R7 SRC RPS6KA6 CRK	2.91e-05	79	91	5	int:MICAL1
GeneFamily	Synaptotagmins	SYT15 SYT6 SYT1	3.05e-05	17	66	3	765
GeneFamily	Mitogen-activated protein kinases	MAPK8 MAPK9	9.97e-04	13	66	2	651
GeneFamily	Dyneins, axonemal	DNAH10 DNAH6	1.72e-03	17	66	2	536
Coexpression	GSE3203_UNTREATED_VS_IFNB_TREATED_LN_BCELL_DN	TPST2 STAC2 MYH14 TNN RPS6KA6 SYT1 ITGA4 MORN5	5.37e-07	200	92	8	M6789
Coexpression	GSE1448_CTRL_VS_ANTI_VALPHA2_DP_THYMOCYTE_UP	PDIA4 DPP6 FLNB MYH14 SRC SYT6 MAPK9	6.87e-06	200	92	7	M3425
CoexpressionAtlas	FacebaseRNAseq_e10.5_Mandibular Arch_top-relative-expression-ranked_1000_k-means-cluster#2	SEC14L3 VWF DNAH10 ADAMTS2 SLC17A1 MYH14 TNN	1.66e-05	197	87	7	Facebase_RNAseq_e10.5_Mandibular Arch_1000_K2
ToppCell	wk_20-22-Mesenchymal-Myofibro_&_SMC-Myofibro_2\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	FZD1 TPST2 FLNA COL12A1 PLXNA4 SYT1 CNN3 ADAMTSL2	6.78e-09	193	92	8	2f203f6f0c2135acb046c9351a633c3b5b254a46
ToppCell	wk_15-18-Mesenchymal-Myofibro_&_SMC-Myofibro_2\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	FZD1 TPST2 FLNA PLXNA4 SYT1 CNN3 ADAMTSL2	3.76e-08	157	92	7	b9d04ee417c0d8ea0801d10f1c54e138587009fd
ToppCell	Control-NK_CD56bright\|Control / Disease condition and Cell class	TPST2 FLNB MAP3K8 FURIN PLXNA4 UGGT2 UNC93B1	1.54e-07	193	92	7	8b1e7a226a6057e1097c1525984127b54e823876
ToppCell	3'-GW_trimst-2-LargeIntestine-Mesenchymal-immature_mesenchymal_cell-Mesoderm_1_(HAND1+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ARG2 ARHGDIA FLNC SRCIN1 CNN3 GAB2	1.40e-06	169	92	6	3f738fc56bbc70dc77c9ba41025631f8264cd2b3
ToppCell	droplet-Lung-3m-Epithelial-airway_epithelial-lung_ciliated_cell-ciliated_cell\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	SEC14L3 DNAH10 MYH14 TNN DNAH6 MORN5	2.52e-06	187	92	6	1bba994aaaa9825b54aaeaff3829850267bc4602
ToppCell	droplet-Lung-3m-Epithelial-airway_epithelial-lung_ciliated_cell\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	SEC14L3 DNAH10 MYH14 TNN DNAH6 MORN5	2.52e-06	187	92	6	d6ac351e7aeba98851d308c14ac395044fe4fbbb
ToppCell	droplet-Lung-3m-Epithelial-airway_epithelial\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	SEC14L3 DNAH10 MYH14 TNN DNAH6 MORN5	2.68e-06	189	92	6	a28e0922e10013ae79266f6a3f9305e6ee614d8b
ToppCell	LA-13._Vascular_Smooth_Muscle\|World / Chamber and Cluster_Paper	A2M FLNA FLNB COBLL1 RPS6KA6 TTLL7	2.68e-06	189	92	6	6b3e88751b95fc2173f2c3d5061ed632d0c5f01c
ToppCell	3'_v3-bone_marrow-Myeloid_Dendritic-pDC\|bone_marrow / Manually curated celltypes from each tissue	FLNB COBLL1 SCARB1 PLXNA4 GPRC5C UNC93B1	2.76e-06	190	92	6	dde0e34f6a06cdbbb65c86472360c09f0279a572
ToppCell	3'_v3-bone_marrow-Myeloid_Dendritic\|bone_marrow / Manually curated celltypes from each tissue	FLNB COBLL1 SCARB1 PLXNA4 GPRC5C UNC93B1	2.76e-06	190	92	6	6892c603037b61ef88d6ca01b7592dc0d347d63b
ToppCell	Fetal_29-31_weeks-Mesenchymal-myofibroblast_cell-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	FZD1 A2M COL12A1 ADGRB3 PLXNA4 SYT1	2.94e-06	192	92	6	72881b280a415e65f87a80ca1369cbb0b722a0c4
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_myocytic\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	FLNA COL12A1 PLXNA4 SYT1 ITGA4 ADAMTSL2	3.03e-06	193	92	6	000b9e6a819b94ea2e6e9173daf97ba9ac2b6cc6
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	A2M FLNA COL12A1 ADAMTS2 SYT1 ADAMTSL2	3.21e-06	195	92	6	803f714d91f2d97ecbee8c15a5139fd9310f66c7
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	A2M FLNA COL12A1 ADAMTS2 SYT1 ADAMTSL2	3.21e-06	195	92	6	4f70157d42a16ff0259bc24a62803c4df4285c44
ToppCell	(08)_PNEC\|World / shred by cell type and Timepoint	DPP6 VWF SYT1 UPP1 KCNB2 CDC14B	3.31e-06	196	92	6	2ee37155c03cd5009427a4bffe6c80ed2ac6939e
ToppCell	facs-Aorta-Heart-3m-Mesenchymal-fibroblast_of_cardiac_tissue\|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SEC14L3 FZD1 FLNC ADAMTS2 MYH14 LOXL2	3.31e-06	196	92	6	2029f58ce6a7b8c35d3a7496c3341391990909ce
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	A2M FLNA COL12A1 ADAMTS2 SYT1 ADAMTSL2	3.40e-06	197	92	6	80e153790cef37b743e22a7370ff5b3a6abf147d
ToppCell	COVID-19-COVID-19_Severe-Myeloid-pDC\|COVID-19_Severe / Disease, condition lineage and cell class	FLNB COBLL1 SCARB1 PLXNA4 GPRC5C UNC93B1	3.51e-06	198	92	6	033ed362333e1d33f2aeea8da5865d2228d154dc
ToppCell	Parenchymal-10x3prime_v2-Stromal-Myofibroblastic-Muscle_perivascular_immune_recruiting\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	FLNC COL12A1 LOXL2 UGGT2 MAPK8 TTLL7	3.71e-06	200	92	6	a372ef3f9e6ff6e3c3376d6e10182977c5067788
ToppCell	LPS-IL1RA+antiTNF-Epithelial_alveolar-AT_1-Airway\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DNAH10 SYT6 UPRT ADAM2 SRCIN1	5.95e-06	124	92	5	a7b7d8b14d1218194da8fcf69b4780b6e9469332
ToppCell	P07-Epithelial-airway_epithelial_cell-ciliated_cell_of_airway\|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	SEC14L3 MYH14 SRC RPS6KA6 UPRT	1.65e-05	153	92	5	5501095bcf73080872ae01128f21399f9cfc5dd1
ToppCell	metastatic_Brain-Fibroblasts-Smooth_muscle_cells\|Fibroblasts / Location, Cell class and cell subclass	FLNA STAC2 UPRT RPS6KL1 TTLL7	1.70e-05	154	92	5	423f58fc7dcef068458cbf7b4ee989e37227041e
ToppCell	droplet-Liver-Npc-21m-Myeloid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SYT15 STAC2 UNC93B1 LYN ADAMTSL2	1.70e-05	154	92	5	d883b3e2a65e4375bea1216eb9bbc86c64ee449c
ToppCell	Children_(3_yrs)-Mesenchymal-airway_smooth_muscle_cell-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	A2M STAC2 ADGRB3 PLXNA4 KCNB2	2.30e-05	164	92	5	e3983f655cdba308fb192182829f17bef99ce0ba
ToppCell	droplet-Thymus-nan-21m-Myeloid-nan\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COBLL1 NUP98 UPP1 UNC93B1 LYN	2.59e-05	168	92	5	69dd747be46e7fbcec571cddd6dee374b9c2507a
ToppCell	E16.5-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Ciliated-Ciliated_mature\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SEC14L3 DNAH10 TNN DNAH6 MORN5	2.59e-05	168	92	5	fa7c0303918cea04e3f4c4f3cb079be19004d214
ToppCell	facs-Heart-RA-18m-Endothelial-endothelial_cell_of_endocardium\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	A2M FLNB VWF CPD IPO11	2.59e-05	168	92	5	06dc5b2d356d3a9454b10bba6f3b9ead2a0a7d46
ToppCell	E16.5-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Ciliated\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SEC14L3 DNAH10 TNN DNAH6 MORN5	2.59e-05	168	92	5	7edcab103c69e928d5c19a0d218ffb3ae32f9e70
ToppCell	facs-Heart-RA-18m-Endothelial-endocardial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	A2M FLNB VWF CPD IPO11	2.59e-05	168	92	5	1002f058a340763e3d8de0bd1f0547a903526ec6
ToppCell	PND07-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_prolif\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SYT15 FLNB VWF FAM91A1 PIGG	2.98e-05	173	92	5	4968712af1cca8c932abd3323631d7dcaffd4a66
ToppCell	Control-Epithelial_cells-AT1\|Control / group, cell type (main and fine annotations)	COL12A1 MYH14 SYT1 MYO16 TTLL7	3.06e-05	174	92	5	548d7f2b958a2bfd2c95eb049ceaab55a559c77d
ToppCell	3'-GW_trimst-2-SmallIntestine-Neuronal-neurons_B-Branch_B3_(IPAN)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	DPP6 SYT6 PLXNA4 SYT1 SRCIN1	3.23e-05	176	92	5	04dad262929581872e5bbc66cd8182c963e7e52f
ToppCell	TCGA-Skin-Metastatic-Melanoma-Skin_Cutaneous_Melanoma-5\|TCGA-Skin / Sample_Type by Project: Shred V9	PDIA4 FZD1 COL12A1 KCNF1 SYT1	3.41e-05	178	92	5	ad5cd505ca1cef8ac29b2af7e2c3e01ebc140c14
ToppCell	COVID-19_Mild-NK_CD56bright\|COVID-19_Mild / Disease condition and Cell class	TPST2 FLNB MAP3K8 FURIN PLXNA4	3.50e-05	179	92	5	90e7a4af195aa2332b07a9f06cde63e72ff49255
ToppCell	wk_15-18-Endothelial-Blood_vessel_endothelial-OMD+_endo\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	FLNB SYT15B VWF COBLL1 MYOM3	3.50e-05	179	92	5	8c9ed247e1c4d655b81ce2f24a9936a7cade718a
ToppCell	droplet-Trachea-3m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l6-17\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	SYT15 VWF SCARB1 SYT6 ADAMTSL2	3.60e-05	180	92	5	455d1e3ccf2ab609954f3b870e8f514ddca735f4
ToppCell	P03-Epithelial-airway_epithelial_cell\|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	SEC14L3 UPK1A TNN DNAH6 MORN5	3.69e-05	181	92	5	1ea21d860d4d7abab3e21e130a16d044006656ee
ToppCell	droplet-Lung-1m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell-pulmonary_artery_endothelial_cell_l25\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	SYT15 FLNB VWF COBLL1 UPP1	3.69e-05	181	92	5	136b0c60680068838d184d32aa99d7bea8718dbc
ToppCell	wk_15-18-Mesenchymal-Myofibro_&_SMC-Early_airway_SMC_2\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	FLNA STAC2 PLXNA4 KCNB2 ADAMTSL2	3.89e-05	183	92	5	a1d4f25e13f5b9e92a9ca0a804a7bed5df8fb2fe
ToppCell	RA-13._Vascular_Smooth_Muscle\|RA / Chamber and Cluster_Paper	A2M FLNA FLNB COBLL1 TTLL7	3.89e-05	183	92	5	818fd886e0188091310825f9145fa53328f2c979
ToppCell	mild_COVID-19-NK_CD56bright\|World / disease group, cell group and cell class (v2)	TPST2 FLNB MAP3K8 FURIN PLXNA4	3.89e-05	183	92	5	9a4899afac0f91203209392c5f67b3d0aa356b86
ToppCell	PBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Myeloid-Dendritic-plasmacytoid_dendritic_cell-DC_c4-LILRA4\|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)	FLNB COBLL1 SCARB1 PLXNA4 UNC93B1	3.89e-05	183	92	5	3b123571e10c132227aff65648b4b3c6acb4bd00
ToppCell	PBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Myeloid-Dendritic-plasmacytoid_dendritic_cell\|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)	FLNB COBLL1 SCARB1 PLXNA4 UNC93B1	3.89e-05	183	92	5	df6fd0927b6e4cf9a1583969a68096e4bccfbace
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Myocytic_interstitial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	FLNA COL12A1 ADGRB3 SYT1 TTLL7	3.89e-05	183	92	5	667717366cb181b8a04a347e64f0f5a4dfc6ee7f
ToppCell	droplet-Heart-HEART_(ALL_MINUS_AORTA)-30m-Endothelial-leukocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLNC DNAH10 PRMT9 GPRC5C DNAH6	3.89e-05	183	92	5	919c9861073d12fd12aecd7469b1478b13838c43
ToppCell	wk_20-22-Mesenchymal-Myofibro_&_SMC-Myofibro_3\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	FZD1 ADGRB3 SYT1 CNN3 ADAMTSL2	3.89e-05	183	92	5	f4ea7113ce9099222743d9ff02388d3d8a9e987b
ToppCell	RA-13._Vascular_Smooth_Muscle\|World / Chamber and Cluster_Paper	A2M FLNA FLNB COBLL1 TTLL7	3.89e-05	183	92	5	cae2ee08f985a6f005b4b8e959e465350315156a
ToppCell	normal_Lung-Fibroblasts-Myofibroblasts\|normal_Lung / Location, Cell class and cell subclass	FLNC COL12A1 ADAMTS2 LOXL2 TNN	3.99e-05	184	92	5	0b336489c10e8c3c957795dd845454f03404382b
ToppCell	nucseq-Epithelial-Epithelial_Alveolar-AT1-AT1\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	COL12A1 MYH14 SYT1 MYO16 TTLL7	3.99e-05	184	92	5	57c792e6e2fedba25d3350ffe649fd74750b579d
ToppCell	normal_Lung-Endothelial_cells-Tumor_ECs\|normal_Lung / Location, Cell class and cell subclass	A2M VWF KCNF1 LOXL2 CNN3	3.99e-05	184	92	5	7ee98acda030366ac6cf3890a6d93fd0426712ed
ToppCell	droplet-Lung-1m-Mesenchymal-myofibroblast-pericyte_cell-pericyte\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	FZD1 COBLL1 SRC GPRC6A TTLL7	3.99e-05	184	92	5	4cb5f299dd7413e0be1ad7af817ee614b23a18ae
ToppCell	droplet-Lung-1m-Mesenchymal-myofibroblast-pericyte_cell\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	FZD1 COBLL1 SRC GPRC6A TTLL7	3.99e-05	184	92	5	39bb0eb55bdc2cea46e41c7f21d8c5883f14e6bd
ToppCell	COVID-19_Mild-Lymphoid_T/NK-NK_CD56bright\|COVID-19_Mild / Disease group, lineage and cell class	TPST2 FLNB MAP3K8 FURIN PLXNA4	3.99e-05	184	92	5	f67308228bb6a5d624279fbb04db25a2f4087c9b
ToppCell	nucseq-Epithelial-Epithelial_Alveolar-AT1\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	COL12A1 MYH14 SYT1 MYO16 TTLL7	3.99e-05	184	92	5	d7bd0f0c607bade67c99e9fb3578a570298bf926
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1\|Children_(3_yrs) / Lineage, Cell type, age group and donor	COL12A1 MYH14 SYT1 MYO16 TTLL7	4.10e-05	185	92	5	1c222f7285d6e3dae0354dc7e853ddc0ea55e63e
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	A2M FLNA COL12A1 ADGRB3 SYT1	4.10e-05	185	92	5	51dfe6ac7df8b330343b37e3bee71e5c65267189
ToppCell	PBMC-Mild-Lymphocyte-T/NK-NK_cell-NK_CD56bright-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	TPST2 FLNB MAP3K8 FURIN PLXNA4	4.10e-05	185	92	5	3a046c948524e5d0e986cd645e318d6930d7e0ee
ToppCell	Adult-Epithelial-alveolar_epithelial_cell_type_1-D175\|Adult / Lineage, Cell type, age group and donor	COL12A1 MYH14 COBLL1 CNN3 TTLL7	4.10e-05	185	92	5	32b4e68e551d435a732f253f6ad83408c759a642
ToppCell	PBMC-Mild-Lymphocyte-T/NK-NK_cell-NK_CD56bright\|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)	TPST2 FLNB MAP3K8 FURIN PLXNA4	4.10e-05	185	92	5	71d1a771026d9fa3528d46ac3d11353e396f2d87
ToppCell	PBMC-Mild-Lymphocyte-T/NK-NK_cell-NK_CD56bright-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	TPST2 FLNB MAP3K8 FURIN PLXNA4	4.10e-05	185	92	5	37b48218dd523049b57b13eb9cdb34e106cf91ea
ToppCell	PBMC-Mild-Lymphocyte-T/NK-NK_cell-NK_CD56bright\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	TPST2 FLNB MAP3K8 FURIN PLXNA4	4.10e-05	185	92	5	df5d2309d19ac8d5e429afa785d0a480e75a8f9e
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	A2M FLNA COL12A1 ADGRB3 SYT1	4.10e-05	185	92	5	a8c02cec3c414f3a0da9f2d6d28ce563b0030705
ToppCell	droplet-Lung-nan-18m-Epithelial-Ciliated_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DPP6 DNAH10 TNN DNAH6 MORN5	4.21e-05	186	92	5	740fd06bcd3b24e6ff2ecf8080f378afc3e95084
ToppCell	5'-GW_trimst-1.5-SmallIntestine-Endothelial-blood_vessel_EC-Mature_venous_EC\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	A2M VWF UPP1 LYN IPO11	4.21e-05	186	92	5	e9d12f2fcd346fc8d00f7178324ea5997628df8a
ToppCell	IPF-Epithelial-ATI\|Epithelial / Disease state, Lineage and Cell class	SYT15 FLNA COL12A1 SYT1 MYO16	4.21e-05	186	92	5	d436ee6cabbde8553ec5e6e55022274090d9f41a
ToppCell	droplet-Lung-nan-18m-Epithelial-ciliated_columnar_cell_of_tracheobronchial_tree\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DPP6 DNAH10 TNN DNAH6 MORN5	4.21e-05	186	92	5	5ab43a298d23238b34e898d11decf0ad81d1b14e
ToppCell	E17.5-Endothelial-capillary_endothelial_cell-capillary_endothelial_cell\|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	TPST2 SCARB1 UPP1 CNN3 IPO11	4.31e-05	187	92	5	e9aa0a5a0f8e2593de63e83b56b53ae33e60af49
ToppCell	COVID-19-Fibroblasts-Airway_smooth_muscle\|COVID-19 / group, cell type (main and fine annotations)	A2M COL12A1 PLXNA4 CNN3 TTLL7	4.31e-05	187	92	5	464a0c3b92b778911b5f9cd73642e09e3472063a
ToppCell	Control-Fibroblasts-Alveolar_FB\|Control / group, cell type (main and fine annotations)	A2M DPP6 ADAMTS2 ADGRB3 ADAMTSL2	4.31e-05	187	92	5	92d468dde81125d51daf7abd4703741abe1ab91c
ToppCell	Adult-Mesenchymal-matrix_fibroblast_1_cell-D175\|Adult / Lineage, Cell type, age group and donor	A2M ADAMTS2 ADGRB3 CNN3 ADAMTSL2	4.31e-05	187	92	5	e15d2967aac248da3517bc2c7d1beaa1d5a0aa7f
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	FLNB COL12A1 MYH14 SYT1 TTLL7	4.31e-05	187	92	5	d4b0afd9b92c47c8aa348bbd1af7eb54c3d478f2
ToppCell	Adult-Epithelial-alveolar_epithelial_cell_type_1\|Adult / Lineage, Cell type, age group and donor	COL12A1 MYH14 SYT1 MYO16 TTLL7	4.31e-05	187	92	5	77f78aec946bc6bd85c29aee9ca978ce49f853a3
ToppCell	Control-Epithelial-ATI\|Epithelial / Disease state, Lineage and Cell class	FLNA COL12A1 SYT1 MYO16 TTLL7	4.31e-05	187	92	5	3a032432f780525f4f4c2a358897d9989b1ecae7
ToppCell	droplet-Kidney-nan-18m-Epithelial-Pecam____Kidney_cortex_artery_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SYT15 VWF PLXNA4 KCNB2 TTLL7	4.31e-05	187	92	5	e93cad16a087d1443cbf4e1690dc1b35d7a84c41
ToppCell	LAM-Lymphoid-pDC\|Lymphoid / Condition, Lineage and Cell class	FLNB COBLL1 SCARB1 PLXNA4 UNC93B1	4.31e-05	187	92	5	4d9ffd2bbdf1c9869e28991ce9331e4ccf3c0166
ToppCell	control-pDC\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	FLNB COBLL1 PLXNA4 GPRC5C UNC93B1	4.31e-05	187	92	5	c78aee98b32719aa45811b620fc97be1ecf5fd53
ToppCell	P03-Endothelial-capillary_endothelial_cell\|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	TPST2 SCARB1 UPP1 LYN CNN3	4.42e-05	188	92	5	ede354ca550840d8f0c8dac22d8ce1f1d325886a
ToppCell	10x3'2.3-week_14-16-Mesenchymal_myocytic-stroma-myofibroblast\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	A2M COL12A1 SYT6 RPS6KA6 CNN3	4.42e-05	188	92	5	116ca07ee4413dcc0e9e5ac99bfee6ed7b7847c6
ToppCell	LA-13._Vascular_Smooth_Muscle\|LA / Chamber and Cluster_Paper	A2M FLNA FLNB COBLL1 TTLL7	4.42e-05	188	92	5	34e1b074a3995aa46ab194eb45115d76d1a5514d
ToppCell	10x_5'_v1-Non-neoplastic-Lymphoid-B_cell-B_cell\|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	VWF COBLL1 LYN RPS6KL1 TTLL7	4.42e-05	188	92	5	99fdd305f75ed38dd507e7a17ffe27c26b86e454
ToppCell	Fetal_29-31_weeks-Mesenchymal-airway_smooth_muscle_cell\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	FLNA FLNC ADGRB3 PLXNA4 CNN3	4.42e-05	188	92	5	4d1e5f85342ae550086609d7680e32730b78b5d2
ToppCell	10x3'2.3-week_14-16-Mesenchymal_myocytic-stroma-muscle_stem_cell\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	FZD1 A2M COL12A1 SYT15B ADGRB3	4.42e-05	188	92	5	de6f4889e0c5f39fbbaefd85526f645c6afa09d5
ToppCell	10x_5'_v1-Non-neoplastic-Lymphoid-B_cell\|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	VWF COBLL1 LYN RPS6KL1 TTLL7	4.42e-05	188	92	5	5a0519b189e96001d95f9d24363448e8602b8d4d
ToppCell	droplet-Lung-nan-18m-Endothelial-Artery_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SYT15 FLNB VWF UPP1 TTLL7	4.42e-05	188	92	5	405efea75233ecf70f7d19b630230798d817b7f2
ToppCell	10x_5'_v1-Non-neoplastic-Lymphoid-B_cell-B_cell-Z\|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	VWF COBLL1 LYN RPS6KL1 TTLL7	4.42e-05	188	92	5	e8b7c1c2eb2e390ad79b358236468b0f15ea58a5
ToppCell	3'_v3-lymph-node_spleen-Myeloid_Dendritic-pDC\|lymph-node_spleen / Manually curated celltypes from each tissue	FLNB SCARB1 PLXNA4 GPRC5C UNC93B1	4.54e-05	189	92	5	6c2ace61a7d62bcf7e76b73e2da8b722d03e713b
ToppCell	Healthy_donor-NK_CD56bright\|Healthy_donor / disease group, cell group and cell class (v2)	TPST2 FLNB MAP3K8 FURIN PLXNA4	4.54e-05	189	92	5	9eac380a3bb4b685effb52d816e1960972660646
ToppCell	PCW_07-8.5-Mesenchymal-Mesenchymal_myocytic\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	FLNA PLXNA4 SYT1 KCNB2 ADAMTSL2	4.54e-05	189	92	5	f75cebd4c3e54e297557449ba67ccc8d1a2a14f5
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_myocytic-mes_immature_ASM2_(12)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	TPST2 FLNA PLXNA4 SYT1 ADAMTSL2	4.54e-05	189	92	5	0abc7a4900cc9033bc1be69b770ccc54a6bf41b4
ToppCell	Neuroendocrine-neuroendo-2-Calca\|World / Class top	DPP6 VWF SYT1 UPP1 CDC14B	4.54e-05	189	92	5	6baa9a74560121cc008bb8fa9b2b7a335b3aeee0
ToppCell	droplet-Trachea-3m-Endothelial-endothelial_cell_of_trachea-tracheal_endothelial_cell-tracheal_endothelial_cell_l10\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	SYT15 VWF SCARB1 UPP1 IPO11	4.54e-05	189	92	5	28b9e96a5206b7fdae9b17daf05c8f5d24b6c5ec
ToppCell	wk_15-18-Mesenchymal-Myofibro_&_SMC-Myofibro_1\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	TPST2 PLXNA4 SYT1 CNN3 ADAMTSL2	4.65e-05	190	92	5	d24af6af3271e34afab744352afd28be8a7cc5c3
ToppCell	PND10-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FZD1 COBLL1 GPRC6A ITGA4 TTLL7	4.65e-05	190	92	5	7e4d80a3a7f83b6a50f1d0fe82fb6c242c39d5b0
ToppCell	Mesenchymal-airway_smooth_muscle_cell\|World / Lineage, Cell type, age group and donor	FLNA FLNC ADGRB3 PLXNA4 CNN3	4.65e-05	190	92	5	645e56b02edc3702c7db917b8ecd5eed0decaf71
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	A2M COL12A1 ADAMTS2 SYT1 ADAMTSL2	4.65e-05	190	92	5	2306aa9dbeaef3be8484a5b236605de23cd75d4c
ToppCell	wk_08-11-Mesenchymal-Myofibro_&_SMC-Myofibro_1\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	TPST2 PLXNA4 SYT1 CNN3 ADAMTSL2	4.65e-05	190	92	5	71a00f63fdd4eb4cc6f190d37e7a0417cdaafacb
ToppCell	myeloid-pDC\|World / Lineage and Cell class	FLNB COBLL1 PLXNA4 GPRC5C UNC93B1	4.65e-05	190	92	5	88c42779ce2f817d28e672d83f3f1158581edf73
ToppCell	facs-Lung-nan-3m-Mesenchymal-pulmonary_interstitial_fibroblast\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL12A1 LOXL2 SYT1 KCNB2 ADAMTSL2	4.65e-05	190	92	5	c7bd087f36321cec61b98657433b4d19d135791f
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	A2M COL12A1 ADAMTS2 SYT1 ADAMTSL2	4.65e-05	190	92	5	1f83f7f24288a3b9ab33c2e113e845dba96adc8a
ToppCell	facs-Lung-nan-3m-Mesenchymal-Myofibroblast\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL12A1 LOXL2 SYT1 KCNB2 ADAMTSL2	4.65e-05	190	92	5	834218fcc59df5e7e52de154272f3d55d81d0dac
Computational	Actin cytoskeleton binding.	FLNA FLNB FLNC CNN3	1.04e-05	30	50	4	MODULE_524
Computational	Genes in the cancer module 419.	FLNA FLNB FLNC CNN3	1.73e-05	34	50	4	MODULE_419
Drug	afimoxifene	FLNA FLNC MAP3K8 RPS6KA6 DKC1 SYT1 MAPK8 RRM1 MAPK9 LYN RPS6KL1 GAB2	4.59e-07	479	91	12	ctd:C016601
Drug	Vinyl Compounds	CYP17A1 MAPK8 MAPK9	1.22e-06	6	91	3	ctd:D014753
Drug	methyl ethyl ketone	VWF MAP3K8 CYP17A1 SRC RPS6KA6 SYT1 CPD MAPK8 MAPK9 LYN CRK GAB2	3.81e-06	587	91	12	CID000006569
Drug	Rgd Peptide	COL12A1 VWF GLCE FURIN SRC ADGRB3 ADAM2 ITGA4	5.27e-06	239	91	8	CID000104802
Drug	N(6),N(6)-dimethyladenine	A2M MAPK8 MAPK9	9.96e-06	11	91	3	ctd:C001020
Drug	dinitrophenyl-bovine serum albumin	MAPK8 MAPK9 LYN	1.32e-05	12	91	3	ctd:C034638
Drug	Acacetin [480-44-4]; Down 200; 14uM; MCF7; HT_HG-U133A	FZD1 A2M TPST2 GLCE COBLL1 SRC CPD	1.34e-05	195	91	7	3942_DN
Drug	AC1L1J0H	VWF SRC SYT1 ITGA4 MAPK8 MAPK9 LYN	1.43e-05	197	91	7	CID000004813
Drug	Pramoxine hydrochloride [637-58-1]; Down 200; 12.2uM; MCF7; HT_HG-U133A	FZD1 MYH14 LOXL2 CYP17A1 FURIN SCARB1 MAPK8	1.43e-05	197	91	7	3894_DN
Drug	AC1L1EOZ	TYR SRCIN1	1.58e-05	2	91	2	CID000002886
Drug	Guanosine	UPP1 MAPK8 MAPK9	1.72e-05	13	91	3	ctd:D006151
Drug	Apigenin	A2M TYR CYP17A1 SRC MAPK8 MAPK9 LYN	1.97e-05	207	91	7	ctd:D047310
Drug	1-((1-O-octadecyl-2-O-methylglycero)phospho)-3-deoxy-myo-inositol	SRC MAPK8 MAPK9	2.71e-05	15	91	3	ctd:C435044
Drug	puag-haad	TYR MAPK8 MAPK9	2.71e-05	15	91	3	ctd:C034912
Drug	benzothiazol-2-ylacetonitrile	MAPK8 MAPK9	4.73e-05	3	91	2	CID000342465
Drug	CGC 11093	MAPK8 MAPK9	4.73e-05	3	91	2	ctd:C515676
Drug	glycine	TYR MGAT5 CYP17A1 GPRC6A RRM1 MAPK9	6.06e-05	169	91	6	CID000000750
Drug	mono-(2-ethylhexyl)phthalate	SLC7A9 TPST2 DPP6 COL12A1 SLC17A1 LOXL2 CYP17A1 SCARB1 SRC MYOM3 UAP1L1	6.28e-05	658	91	11	ctd:C016599
Drug	chromium	PDIA4 A2M FURIN SRC ITGA4 MAPK8 MAPK9 LYN	6.46e-05	339	91	8	CID000023976
Drug	N,N-dimethyl-5H-purin-6-amine	UPP1 MAPK8 MAPK9	6.70e-05	20	91	3	CID000436439
Disease	myofibrillar myopathy 5 (implicated_via_orthology)	FLNA FLNB FLNC	2.56e-08	3	88	3	DOID:0080096 (implicated_via_orthology)
Disease	distal muscular dystrophy 4 (implicated_via_orthology)	FLNA FLNB FLNC	2.56e-08	3	88	3	DOID:0111190 (implicated_via_orthology)
Disease	Liver Cirrhosis, Experimental	A2M FLNA COL12A1 MGAT5 VWF SLC17A1 ACOT9 MAP3K8 LOXL2 CYP17A1 UNC93B1	1.92e-05	774	88	11	C0023893
Disease	palmitoleic acid measurement	MLLT1 HIF1AN	1.83e-04	7	88	2	EFO_0007973
Disease	vascular cell adhesion protein 1 measurement	MGAT5 ITGA4	1.83e-04	7	88	2	EFO_0020846
Disease	factor VIII measurement, coronary artery disease	SEC14L3 VWF FURIN SCARB1	3.71e-04	113	88	4	EFO_0001645, EFO_0004630
Disease	myopathy (implicated_via_orthology)	FLNA FLNB FLNC	4.02e-04	48	88	3	DOID:423 (implicated_via_orthology)
Disease	Dental enamel hypoplasia	MYH14 SYT1	5.69e-04	12	88	2	EFO_1001304
Disease	Trigeminal Neuralgia	MAPK8 MAPK9	5.69e-04	12	88	2	C0040997
Disease	Secondary Trigeminal Neuralgia	MAPK8 MAPK9	5.69e-04	12	88	2	C0393787
Disease	Trigeminal Neuralgia, Idiopathic	MAPK8 MAPK9	5.69e-04	12	88	2	C0393786
Disease	response to opioid	SLC7A9 MGAT5 ADAMTSL2	8.14e-04	61	88	3	EFO_0008541
Disease	urinary metabolite measurement	SLC7A9 SLC17A1 DNAJC16 CDH7 MYO16	8.47e-04	245	88	5	EFO_0005116
Disease	Hepatitis C	LOXL2 SCARB1	9.00e-04	15	88	2	C0019196
Disease	employment status	PLXNA4 IPO11	9.00e-04	15	88	2	EFO_0005241
Disease	Spondyloepiphyseal Dysplasia	FLNA ADAMTSL2	1.03e-03	16	88	2	C0038015
Disease	Spondyloepiphyseal Dysplasia Tarda, X-Linked	FLNA ADAMTSL2	1.03e-03	16	88	2	C3541456
Disease	Schwartz-Jampel Syndrome, Type 1	FLNA ADAMTSL2	1.03e-03	16	88	2	C4551479
Disease	Schwartz-Jampel Syndrome	FLNA ADAMTSL2	1.03e-03	16	88	2	C0036391
Disease	Melnick-Needles Syndrome	FLNA ADAMTSL2	1.03e-03	16	88	2	C0025237
Disease	low density lipoprotein cholesterol measurement, body fat percentage	DNAH10 COBLL1	1.16e-03	17	88	2	EFO_0004611, EFO_0007800
Disease	Van Buchem disease	FLNA ADAMTSL2	1.16e-03	17	88	2	C0432272
Disease	tissue plasminogen activator measurement, coronary artery disease	SEC14L3 FURIN SCARB1	1.27e-03	71	88	3	EFO_0001645, EFO_0004791
Disease	metabolite measurement	SLC7A9 SLC17A1 DNAJC16 SCARB1 PIWIL1 SYT1 TMEM68	1.44e-03	560	88	7	EFO_0004725
Disease	osteochondrodysplasia (is_implicated_in)	FLNA FLNB	1.45e-03	19	88	2	DOID:2256 (is_implicated_in)
Disease	body mass index, high density lipoprotein cholesterol measurement	DNAH10 COBLL1	1.45e-03	19	88	2	EFO_0004340, EFO_0004612
Disease	Osteochondrodysplasias	FLNA ADAMTSL2	1.45e-03	19	88	2	C0029422
Disease	Dyschondroplasias	FLNA ADAMTSL2	1.45e-03	19	88	2	C0013366
Disease	triglyceride measurement, body mass index	DNAH10 COBLL1	1.45e-03	19	88	2	EFO_0004340, EFO_0004530
Disease	Multiple Epiphyseal Dysplasia	FLNA ADAMTSL2	1.61e-03	20	88	2	C0026760
Disease	triglyceride measurement, body fat percentage	DNAH10 COBLL1	1.78e-03	21	88	2	EFO_0004530, EFO_0007800
Disease	fatty acid measurement	MGAT5 COBLL1 SCARB1 PLXNA4 HIF1AN CNN3	1.97e-03	436	88	6	EFO_0005110
Disease	Hepatolenticular Degeneration	A2M LOXL2	2.33e-03	24	88	2	C0019202
Disease	Hepatic Form of Wilson Disease	A2M LOXL2	2.33e-03	24	88	2	C1527352
Disease	response to peginterferon alfa-2a	VWF CDC14B	2.52e-03	25	88	2	EFO_0010103
Disease	body fat percentage, high density lipoprotein cholesterol measurement	DNAH10 COBLL1	2.52e-03	25	88	2	EFO_0004612, EFO_0007800
Disease	neutrophil count	SEC14L3 FLNB STAC2 TAS2R7 FURIN SYT6 SYT1 ITGA4 LYN FGGY CRK	2.68e-03	1382	88	11	EFO_0004833

Protein segments in the cluster

Peptide	Gene	Start	Entry
LMDIYPTLSYIGGGI	ARSH	381	Q5FYA8
PVVGGLTYREGMYIA	ARG2	266	P78540
PYTTEKMSRVPGGYL	PRMT9	351	Q6P2P2
GVIYGSYSVSEMFPK	ADGRB3	36	O60242
RVYSYSGTGIMKPLD	ADAM2	71	Q99965
GYIEGYPKSVVMVST	ADAM2	96	Q99965
VGCYMVIYLGRTPEE	CDC14B	136	O60729
YGGIYMDTDVISIRP	A4GNT	161	Q9UNA3
PKTYGESMLYLDGQR	ACOT9	406	Q9Y305
KAMLPLYDTGSGTIY	GLCE	546	O94923
KEYKMGVPTYGAIIL	DCP2	91	Q8IU60
ITREYIPKIGMTTYK	COBLL1	721	Q53SF7
IPVGDTRVSLTYKYM	ADAMTS2	821	O95450
YYLIMAKGGIVRTGT	A2M	496	P01023
EGKRGMIPVPYVEKY	CRK	176	P46108
YRAPEVILGMGYKEN	MAPK9	191	P45984
KYSLSPGIGYMIQDT	PADI6	391	Q6TGC4
LTKVGYYTIPSMDDL	NUP98	736	P52948
ILPYIGTTVGSMEEY	OR2T1	41	O43869
GPYAGVMTAYDLKKT	MGAT5	71	Q09328
YETVVGPGDVLYIPM	HIF1AN	261	Q9NWT6
GVLEMVKIFRYGYPV	MYO16	1066	Q9Y6X6
GERYPVVMSTYLGVM	IPO11	781	Q9UI26
MVKGLRITPFSYYTG	FAM91A1	86	Q658Y4
ILSTYRKRTPVMEGY	LOXL2	191	Q9Y4K0
VYFPKDLRGTEIYMS	MAP3K8	281	P41279
IPDKTGRYMIGVTYG	FLNB	1581	O75369
LPIYTEAIVEMYRGK	MYH14	151	Q7Z406
VERYYSDIGKMPAIS	PLXNA4	1811	Q9HCM2
YRAPEVILGMGYKEN	MAPK8	191	P45983
VKYTPPGAGRYTIMV	FLNC	831	Q14315
MSGRYTITIKYGGDE	FLNC	1606	Q14315
GYVYVGLRGTEEMTR	DNAJC16	301	Q9Y2G8
GTVVKYRRPMDVYET	ADAMTSL2	281	Q86TH1
RYVYLVTDLMKGGEL	RPS6KA6	491	Q9UK32
MYPTRGVGYETILKE	GPRC5C	316	Q9NQ84
YMPRVKAVIGSGYSE	GPRC6A	136	Q5T6X5
EPTKVYGLMYFGPEE	FZD1	301	Q9UP38
PTTDTVRYGYLMEKL	DNAH6	2071	Q9C0G6
TITMTTVGYGDIYPK	KCNB2	376	Q92953
IYLDGYTSPGFKMLE	COL12A1	2511	Q99715
KTDYMVGSYGPRAEE	ARHGDIA	141	P52565
MSGGEQKPERYYVGV	FGGY	1	Q96C11
VKYTPRGAGSYTIMV	FLNA	836	P21333
GVKVYTMDRGLISYK	FURIN	746	P09958
LGTMITKSGGEYPYL	SLC7A9	86	P82251
LQKKYGPIYSVRMGT	CYP17A1	56	P05093
DGGSMLVTYPYDKPV	CPD	1096	O75976
REEPIYIITEYMAKG	LYN	311	P07948
YTKDLIVMGAPGSSY	ITGA4	206	P13612
GKEVPGYIVLFYNMS	ITGA4	506	P13612
VLEEYMGSDPLYVGK	CDH7	56	Q9ULB5
YKVEESGYAGFIMPI	MLLT1	71	Q03111
MELPTYTGSIYPTVK	DPP6	326	P42658
YGAKIMLPGVLRYED	DKC1	311	O60832
PVRGLSVTYYLEAKM	DNAH10	1311	Q8IVF4
YEKLGDISYPEMVTG	SLC13A4	366	Q9UKG4
TKINYGGEIPKSMYV	SEC14L3	256	Q9UDX4
EYMPSRIIVYRDGVG	PIWIL1	691	Q96J94
SGRMSGDPDVLEYYK	GAB2	36	Q9UQC2
PYSELGGKTLVMAVY	SYT1	216	P21579
MDITGYSDPYVKVSL	SYT6	391	Q5T7P8
GTDRYAMYKVGPVLS	UPP1	91	Q16831
PIYIVTEYMSKGSLL	SRC	336	P12931
RVVVGPYMYTRGREL	SYT15	381	Q9BQS2
LRYEGLMGKPSILTY	HDHD5	271	Q9BXW7
VPVGYFSGIYSTKKM	SLC17A1	96	Q14916
LPAGGISYVVYEAMK	SLC25A41	351	Q8N5S1
MYKESGVFEGIPTYR	SCARB1	286	Q8WTV0
EKYGIVDYMIEQSGP	PDIA4	271	P13667
KGMSVYGLGRQVYDP	CNN3	256	Q15417
LYPDVYATGKEMRII	TAS2R7	71	Q9NYW3
EYRYGKAMPLIFVGG	TPST2	61	O60704
MDDLRYGVYPVKGAS	ZNF738	1	Q8NE65
ALLMYVGPGVYKEVI	WDR90	1646	Q96KV7
DETYREVKYGNMGLP	UNC93B1	91	Q9H1C4
MYGGFPVKLRTYLGD	TMEM68	266	Q96MH6
MPYASKGLYLETEAG	VWF	111	P04275
GMVLVKGEGLYADPY	SRCIN1	386	Q9C0H9
TEVDYYKLRYGPMTG	TNN	376	Q9UQP3
YKLRYGPMTGQEVAE	TNN	381	Q9UQP3
YEGSPVSKGILQYDM	RRM1	556	P23921
TLRKDVGPMYSYVAL	STAC2	286	Q6ZMT1
VVGPYMYTRGRELEH	SYT15B	436	X6R8R1
SSDYVIPIGTYGQMK	TYR	146	P14679
GTRLGVTYPKGMYRV	UAP1L1	116	Q3KQV9
GVPYMTKLLRYFVSE	RPS6KL1	196	Q9Y6S9
YRVYPLMGVSGKDDV	UPK1A	46	O00322
KMVYSYLPALGKTGV	SLF1	706	Q9BQI6
KPSSRKMYLSGYGVE	UGGT2	221	Q9NYU1
GVKFMPYTTYLVEKG	PIGG	86	Q5H8A4
MVTTPTGYKYEGVKF	UPRT	161	Q96BW1
YHDGLVRMGTEKYIP	TTLL7	221	Q6ZT98
AKYILPTETIYVGEM	MORN5	21	Q5VZ52
ITMTTVGYGDIYPKT	KCNF1	366	Q9H3M0
YKEDEGLYMVRVPSP	MYOM3	336	Q5VTT5