Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	acetylspermidine deacetylase activity	HDAC6 HDAC10	3.64e-05	2	121	2	GO:0047611
GeneOntologyBiologicalProcess	spermidine deacetylation	HDAC6 HDAC10	3.36e-05	2	120	2	GO:0106048
GeneOntologyBiologicalProcess	polyamine deacetylation	HDAC6 HDAC10	3.36e-05	2	120	2	GO:0106047
Domain	Hist_deacetyl	HDAC6 HDAC7 HDAC10	3.34e-05	11	112	3	PF00850
Domain	-	HDAC6 HDAC7 HDAC10	3.34e-05	11	112	3	3.40.800.20
Domain	His_deacetylse_dom	HDAC6 HDAC7 HDAC10	3.34e-05	11	112	3	IPR023801
Domain	His_deacetylse	HDAC6 HDAC7 HDAC10	3.34e-05	11	112	3	IPR000286
Domain	RFX1_trans_act	RFX2 RFX3	1.07e-04	3	112	2	IPR007668
Domain	RFX1_trans_act	RFX2 RFX3	1.07e-04	3	112	2	PF04589
Domain	P5-ATPase	ATP13A5 ATP13A2	2.12e-04	4	112	2	PF12409
Domain	P-type_TPase_V	ATP13A5 ATP13A2	3.52e-04	5	112	2	IPR006544
Domain	Calx_beta	FRAS1 ADGRV1	9.75e-04	8	112	2	SM00237
Domain	ARM-type_fold	GBF1 LRRK2 APOB HEATR5A TRRAP FOCAD AP1G2 HEATR5B	1.00e-03	339	112	8	IPR016024
Domain	Calx_beta	FRAS1 ADGRV1	1.25e-03	9	112	2	IPR003644
Domain	RFX_DNA_binding	RFX2 RFX3	1.25e-03	9	112	2	PF02257
Domain	DNA-bd_RFX	RFX2 RFX3	1.25e-03	9	112	2	IPR003150
Domain	Calx-beta	FRAS1 ADGRV1	1.25e-03	9	112	2	PF03160
Domain	RFX_DBD	RFX2 RFX3	1.25e-03	9	112	2	PS51526
Domain	FERM_M	EPB41L4B MYO15A FERMT3	2.64e-03	46	112	3	PF00373
Domain	FERM_central	EPB41L4B MYO15A FERMT3	3.16e-03	49	112	3	IPR019748
Domain	FERM_1	EPB41L4B MYO15A FERMT3	3.35e-03	50	112	3	PS00660
Domain	FERM_2	EPB41L4B MYO15A FERMT3	3.35e-03	50	112	3	PS00661
Domain	FERM_3	EPB41L4B MYO15A FERMT3	3.35e-03	50	112	3	PS50057
Domain	Band_41_domain	EPB41L4B MYO15A FERMT3	3.35e-03	50	112	3	IPR019749
Domain	B41	EPB41L4B MYO15A FERMT3	3.35e-03	50	112	3	SM00295
Domain	Cation_ATPase_N	ATP13A5 ATP13A2	5.12e-03	18	112	2	SM00831
Domain	ATPase_P-typ_cation-transptr_N	ATP13A5 ATP13A2	5.70e-03	19	112	2	IPR004014
Domain	ARM-like	LRRK2 DAXX HEATR5A TRRAP AP1G2 HEATR5B	5.76e-03	270	112	6	IPR011989
Pathway	REACTOME_PROCESSIVE_SYNTHESIS_ON_THE_LAGGING_STRAND	POLD1 POLA2 LIG1	6.80e-05	15	77	3	MM15373
Pathway	REACTOME_PROCESSIVE_SYNTHESIS_ON_THE_LAGGING_STRAND	POLD1 POLA2 LIG1	6.80e-05	15	77	3	M744
Pathway	REACTOME_LAGGING_STRAND_SYNTHESIS	POLD1 POLA2 LIG1	1.67e-04	20	77	3	M9461
Pathway	REACTOME_LAGGING_STRAND_SYNTHESIS	POLD1 POLA2 LIG1	1.67e-04	20	77	3	MM15374
Pathway	REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY	HDAC6 HDAC7 HDAC10	2.57e-04	23	77	3	MM14954
Pathway	REACTOME_DNA_STRAND_ELONGATION	POLD1 POLA2 LIG1	2.92e-04	24	77	3	MM15375
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	SRXN1 FRAS1 GBF1 HECTD4 CBLC ITGA3 TRRAP ATP13A2 HDAC7 AHDC1 SYNE4 TFE3 HIRA FOCAD NEK8 SBF2 HPS6 AP1G2 TNKS1BP1 ESPL1 ALKBH6 PRRT4	4.15e-11	1105	122	22	35748872
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	GBF1 HDAC6 CAMSAP3 CBLC DAXX POLA2 TRRAP HDAC7 SMTN LIG1 TAF3 HELZ TNKS1BP1 ELK3 ESPL1	9.66e-08	774	122	15	15302935
Pubmed	ATP13A2 facilitates HDAC6 recruitment to lysosome to promote autophagosome-lysosome fusion.	HDAC6 ATP13A2 HDAC7	1.68e-07	4	122	3	30538141
Pubmed	Genome-wide ENU mutagenesis in combination with high density SNP analysis and exome sequencing provides rapid identification of novel mouse models of developmental disease.	AMH FRAS1 LIG1	4.19e-07	5	122	3	23469164
Pubmed	A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning.	HDAC6 POLD1 DAXX OCRL POLA2 TFE3 SBF2 HPS6 RNF10 DOCK7 ARHGAP29 AP1G2 TNKS1BP1 HEATR5B ESPL1	3.77e-06	1038	122	15	26673895
Pubmed	Histone Deacetylase 1 Is Essential for Rod Photoreceptor Differentiation by Regulating Acetylation at Histone H3 Lysine 9 and Histone H4 Lysine 12 in the Mouse Retina.	HDAC6 HDAC7 HDAC10	4.96e-06	10	122	3	28028172
Pubmed	G-protein pathway suppressor 2 (GPS2) interacts with the regulatory factor X4 variant 3 (RFX4_v3) and functions as a transcriptional co-activator.	FBF1 RFX2 RFX3	6.81e-06	11	122	3	18218630
Pubmed	Fast-evolving cofactors regulate the role of HEATR5 complexes in intra-Golgi trafficking.	HEATR5A HEATR5B	1.22e-05	2	122	2	38240799
Pubmed	PSF/SFPQ is a very common gene fusion partner in TFE3 rearrangement-associated perivascular epithelioid cell tumors (PEComas) and melanotic Xp11 translocation renal cancers: clinicopathologic, immunohistochemical, and molecular characteristics suggesting classification as a distinct entity.	SFPQ TFE3	1.22e-05	2	122	2	26274027
Pubmed	Melanotic Xp11 translocation renal cancer: a case with PSF-TFE3 gene fusion and up-regulation of melanogenetic transcripts.	SFPQ TFE3	1.22e-05	2	122	2	19809274
Pubmed	Isolation and characterization of mammalian HDAC10, a novel histone deacetylase.	HDAC6 HDAC10	1.22e-05	2	122	2	11677242
Pubmed	SFPQ/PSF-TFE3 renal cell carcinoma: a clinicopathologic study emphasizing extended morphology and reviewing the differences between SFPQ-TFE3 RCC and the corresponding mesenchymal neoplasm despite an identical gene fusion.	SFPQ TFE3	1.22e-05	2	122	2	28315422
Pubmed	ATP13A2 and Alpha-synuclein: a Metal Taste in Autophagy.	HDAC6 ATP13A2	1.22e-05	2	122	2	25548531
Pubmed	Histone deacetylase 10 structure and molecular function as a polyamine deacetylase.	HDAC6 HDAC10	1.22e-05	2	122	2	28516954
Pubmed	Histone deacetylase expression patterns in developing murine optic nerve.	HDAC6 HDAC7 HDAC10	1.49e-05	14	122	3	25011550
Pubmed	HDAC family: What are the cancer relevant targets?	HDAC6 HDAC7 HDAC10	3.31e-05	18	122	3	18824292
Pubmed	Involvement of RFX proteins in transcriptional activation from a Ras-responsive enhancer element.	RFX2 RFX3	3.65e-05	3	122	2	15024578
Pubmed	Dimeric RFX proteins contribute to the activity and lineage specificity of the interleukin-5 receptor alpha promoter through activation and repression domains.	RFX2 RFX3	3.65e-05	3	122	2	10330134
Pubmed	Ciliogenic RFX transcription factors regulate FGF1 gene promoter.	RFX2 RFX3	3.65e-05	3	122	2	22415835
Pubmed	H3.Y discriminates between HIRA and DAXX chaperone complexes and reveals unexpected insights into human DAXX-H3.3-H4 binding and deposition requirements.	DAXX HIRA	3.65e-05	3	122	2	28334823
Pubmed	High-resolution arrays reveal burden of copy number variations on Parkinson disease genes associated with increased disease risk in random cohorts.	LRRK2 ATP13A2	3.65e-05	3	122	2	27399248
Pubmed	Identification of HDAC10, a novel class II human histone deacetylase containing a leucine-rich domain.	HDAC6 HDAC10	3.65e-05	3	122	2	11861901
Pubmed	Drosophila regulatory factor X is necessary for ciliated sensory neuron differentiation.	RFX2 RFX3	3.65e-05	3	122	2	12403718
Pubmed	Prostaglandin I2 Receptor Agonism Preserves β-Cell Function and Attenuates Albuminuria Through Nephrin-Dependent Mechanisms.	NPHS1 NOS3	3.65e-05	3	122	2	26868296
Pubmed	Fusion of splicing factor genes PSF and NonO (p54nrb) to the TFE3 gene in papillary renal cell carcinoma.	SFPQ TFE3	3.65e-05	3	122	2	9393982
Pubmed	Interplay of RFX transcription factors 1, 2 and 3 in motile ciliogenesis.	RFX2 RFX3	3.65e-05	3	122	2	32725242
Pubmed	Down-regulation of LRRK2 in control and DAT transfected HEK cells increases manganese-induced oxidative stress and cell toxicity.	LRRK2 ATP13A2	3.65e-05	3	122	2	23628791
Pubmed	Lifestyle and socioeconomic-status modify the effects of ADRB2 and NOS3 on adiposity in European-American and African-American adolescents.	APOB NOS3	3.65e-05	3	122	2	20930716
Pubmed	RFX1, a transactivator of hepatitis B virus enhancer I, belongs to a novel family of homodimeric and heterodimeric DNA-binding proteins.	RFX2 RFX3	3.65e-05	3	122	2	8289803
Pubmed	A directed protein interaction network for investigating intracellular signal transduction.	HDAC6 TAF1C CAMSAP3 CBLC DAXX AIDA POLA2 ATP13A2 SYNE4 FOCAD LIG1 SIMC1 HPS6 DOCK7	4.18e-05	1124	122	14	21900206
Pubmed	DCAF8, a novel MuRF1 interaction partner, promotes muscle atrophy.	POLD1 DAXX HIRA RNF10 DOCK7 ARHGAP29 HDAC10 CCDC17	4.55e-05	364	122	8	31391242
Pubmed	Fras1, a basement membrane-associated protein mutated in Fraser syndrome, mediates both the initiation of the mammalian kidney and the integrity of renal glomeruli.	NPHS1 FRAS1 ITGA3	7.09e-05	23	122	3	18787044
Pubmed	Securin and separase phosphorylation act redundantly to maintain sister chromatid cohesion in mammalian cells.	PTTG3P ESPL1	7.29e-05	4	122	2	16030258
Pubmed	Human regulatory factor X 4 (RFX4) is a testis-specific dimeric DNA-binding protein that cooperates with other human RFX members.	RFX2 RFX3	7.29e-05	4	122	2	11682486
Pubmed	Differential expression of Rfx1-4 during mouse spermatogenesis.	RFX2 RFX3	7.29e-05	4	122	2	19596083
Pubmed	Preimplantation mouse embryos depend on inhibitory phosphorylation of separase to prevent chromosome missegregation.	PTTG3P ESPL1	7.29e-05	4	122	2	19124608
Pubmed	A high-lipid diet potentiates left ventricular dysfunction in nitric oxide synthase 3-deficient mice after chronic pressure overload.	NEK8 NOS3	7.29e-05	4	122	2	20554900
Pubmed	Structural imaging in the presymptomatic stage of genetically determined parkinsonism.	LRRK2 ATP13A2	7.29e-05	4	122	2	20483373
Pubmed	HJURP antagonizes CENP-A mislocalization driven by the H3.3 chaperones HIRA and DAXX.	DAXX HIRA	7.29e-05	4	122	2	30365520
Pubmed	Securin is not required for cellular viability, but is required for normal growth of mouse embryonic fibroblasts.	PTTG3P ESPL1	7.29e-05	4	122	2	11516952
Pubmed	FTH1 binds to Daxx and inhibits Daxx-mediated cell apoptosis.	BTBD6 DAXX	7.29e-05	4	122	2	21573799
Pubmed	The selective continued linkage of centromeres from mitosis to interphase in the absence of mammalian separase.	PTTG3P ESPL1	7.29e-05	4	122	2	16533944
Pubmed	Separase: a universal trigger for sister chromatid disjunction but not chromosome cycle progression.	PTTG3P ESPL1	7.29e-05	4	122	2	16533945
Pubmed	Dynamic DNA-bound PCNA complexes co-ordinate Okazaki fragment synthesis, processing and ligation.	POLD1 LIG1	7.29e-05	4	122	2	33157085
Pubmed	Distinct factors control histone variant H3.3 localization at specific genomic regions.	DAXX HIRA	1.21e-04	5	122	2	20211137
Pubmed	Deactylase inhibitors disrupt cellular complexes containing protein phosphatases and deacetylases.	HDAC6 HDAC10	1.21e-04	5	122	2	14670976
Pubmed	Characterization of the P5 subfamily of P-type transport ATPases in mice.	ATP13A5 ATP13A2	1.21e-04	5	122	2	15381061
Pubmed	The meiosis I-to-meiosis II transition in mouse oocytes requires separase activity.	PTTG3P ESPL1	1.21e-04	5	122	2	14561405
Pubmed	Parkinson disease related ATP13A2 evolved early in animal evolution.	ATP13A5 ATP13A2	1.21e-04	5	122	2	29505581
Pubmed	c-Cbl and Cbl-b act redundantly to protect osteoclasts from apoptosis and to displace HDAC6 from beta-tubulin, stabilizing microtubules and podosomes.	HDAC6 CBLC	1.21e-04	5	122	2	19641021
Pubmed	Prognosis of young ischemic stroke in Taiwan: impact of prothrombotic genetic polymorphisms.	ITGA3 NOS3	1.21e-04	5	122	2	15351855
Pubmed	Interrogating translational efficiency and lineage-specific transcriptomes using ribosome affinity purification.	HDAC7 ELK3 NOS3	1.44e-04	29	122	3	24003143
Pubmed	Forty-three loci associated with plasma lipoprotein size, concentration, and cholesterol content in genome-wide analysis.	APOB SBF2 DOCK7	1.60e-04	30	122	3	19936222
Pubmed	DAXX-dependent supply of soluble (H3.3-H4) dimers to PML bodies pending deposition into chromatin.	DAXX HIRA	1.81e-04	6	122	2	23222847
Pubmed	Polymorphisms associated with apolipoprotein B levels in Greek patients with familial hypercholesterolemia.	APOB NOS3	1.81e-04	6	122	2	16776623
Pubmed	RFX2 is essential in the ciliated organ of asymmetry and an RFX2 transgene identifies a population of ciliated cells sufficient for fluid flow.	RFX2 RFX3	2.53e-04	7	122	2	22233545
Pubmed	[Population study of the Udmurt population: analysis of ten polymorphic DNA loci of the nuclear genome].	APOB NOS3	2.53e-04	7	122	2	17633563
Pubmed	HIRA and Daxx constitute two independent histone H3.3-containing predeposition complexes.	DAXX HIRA	2.53e-04	7	122	2	21047901
Pubmed	Smarcal1-Mediated Fork Reversal Triggers Mre11-Dependent Degradation of Nascent DNA in the Absence of Brca2 and Stable Rad51 Nucleofilaments.	POLD1 POLA2	2.53e-04	7	122	2	28757209
Pubmed	In vivo and in vitro investigations of heterozygous nebulin knock-out mice disclose a mild skeletal muscle phenotype.	LRTM2 POLA2 DGLUCY C9orf50 TAP1	2.60e-04	160	122	5	23375831
Pubmed	DNA polymerase δ and ζ switch by sharing accessory subunits of DNA polymerase δ.	POLD1 POLA2	3.37e-04	8	122	2	22465957
Pubmed	Systematic proteomic analysis of LRRK2-mediated Rab GTPase phosphorylation establishes a connection to ciliogenesis.	LRRK2 OCRL	3.37e-04	8	122	2	29125462
Pubmed	Differential expression of HDAC and HAT genes in atrophying skeletal muscle.	HDAC6 HDAC7	3.37e-04	8	122	2	26372908
Pubmed	A Cul4 E3 ubiquitin ligase regulates histone hand-off during nucleosome assembly.	DAXX HIRA	3.37e-04	8	122	2	24209620
Pubmed	RPA Interacts with HIRA and Regulates H3.3 Deposition at Gene Regulatory Elements in Mammalian Cells.	DAXX HIRA	3.37e-04	8	122	2	28107649
Pubmed	Normal lytic granule secretion by cytotoxic T lymphocytes deficient in BLOC-1, -2 and -3 and myosins Va, VIIa and XV.	HPS6 MYO15A	3.37e-04	8	122	2	15702992
Pubmed	Genetic mapping of 18S ribosomal RNA-related loci to mouse chromosomes 5, 6, 9, 12, 17, 18, 19, and X.	APOB NOS3	4.32e-04	9	122	2	8995758
Pubmed	Activity-dependent genes in mouse olfactory sensory neurons.	NPHS1 PTPRN	4.32e-04	9	122	2	24692514
Pubmed	Reconstitution of proliferating cell nuclear antigen-dependent repair of apurinic/apyrimidinic sites with purified human proteins.	POLD1 LIG1	4.32e-04	9	122	2	10559261
Pubmed	The mouse Kreisler (Krml1/MafB) segmentation gene is required for differentiation of glomerular visceral epithelial cells.	NPHS1 ITGA3	4.32e-04	9	122	2	12217315
Pubmed	A composite scoring of genotypes discriminates coronary heart disease risk beyond conventional risk factors in the Boston Puerto Rican Health Study.	APOB NOS3	4.32e-04	9	122	2	19501493
Pubmed	Histone deacetylases 5 and 9 govern responsiveness of the heart to a subset of stress signals and play redundant roles in heart development.	HDAC6 HDAC7	4.32e-04	9	122	2	15367668
Pubmed	The bZIP repressor proteins, c-Jun dimerization protein 2 and activating transcription factor 3, recruit multiple HDAC members to the ATF3 promoter.	HDAC6 HDAC10	4.32e-04	9	122	2	22989952
Pubmed	UV-Induced RPA1 Acetylation Promotes Nucleotide Excision Repair.	HDAC6 ATRIP	4.32e-04	9	122	2	28854355
Pubmed	Global genetic analysis in mice unveils central role for cilia in congenital heart disease.	FRAS1 RFX3 ACAN NEK8	4.36e-04	100	122	4	25807483
Pubmed	Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	ZCCHC2 SBF2 DOCK7 TNKS1BP1	4.70e-04	102	122	4	11214970
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	FRAS1 EPB41L4B LONP2 CAMSAP3 POLR3A AP5B1 DOCK7 HELZ METTL16	4.94e-04	650	122	9	38777146
Pubmed	Novel gene function revealed by mouse mutagenesis screens for models of age-related disease.	ADGRV1 ACAN MYO15A	5.02e-04	44	122	3	27534441
Pubmed	Genetic polymorphisms associated with thrombophilia and vascular disease in women with unexplained late intrauterine fetal death: a multicenter study.	APOB ITGA3	5.39e-04	10	122	2	14706682
Pubmed	The nuclear import of TAF10 is regulated by one of its three histone fold domain-containing interaction partners.	TRRAP TAF3	5.39e-04	10	122	2	15870280
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	FBF1 HECTD4 ADGRV1 NRXN3 RNF10 PAN2 TNKS1BP1 ESPL1	5.76e-04	529	122	8	14621295
Pubmed	The cell proliferation antigen Ki-67 organises heterochromatin.	FRAS1 LONP2 TRRAP RFX3 HIRA ATRIP DOCK7	6.30e-04	410	122	7	26949251
Pubmed	Hdac6 regulates Tip60-p400 function in stem cells.	SFPQ HDAC6 TRRAP	6.49e-04	48	122	3	24302573
Pubmed	Do polymorphisms in the familial Parkinsonism genes contribute to risk for sporadic Parkinson's disease?	LRRK2 ATP13A2	6.57e-04	11	122	2	19224617
Pubmed	Separase phosphosite mutation leads to genome instability and primordial germ cell depletion during oogenesis.	PTTG3P ESPL1	6.57e-04	11	122	2	21494564
Pubmed	Phosphorylation of H4 Ser 47 promotes HIRA-mediated nucleosome assembly.	DAXX HIRA	6.57e-04	11	122	2	21724829
Pubmed	The aftiphilin/p200/gamma-synergin complex.	HEATR5A HEATR5B	6.57e-04	11	122	2	15758025
Pubmed	Proteomic profiling of Myc-associated proteins.	TRRAP SMTN NRXN3 HELZ	7.14e-04	114	122	4	21150319
Pubmed	Sequential genome-wide CRISPR-Cas9 screens identify genes regulating cell-surface expression of tetraspanins.	CAMSAP3 LRTM2 SMTN FOCAD NEK8 MCUR1 PRSS50 C9orf50 METTL16 TRAPPC14	7.22e-04	832	122	10	36724073
Pubmed	An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.	LONP2 POLD1 CAMSAP3 OCRL RFX3 HDAC7 MTPAP NEK8 DOCK7 PAN2 HELZ TNKS1BP1 TMEM102	7.67e-04	1321	122	13	27173435
Pubmed	RPA governs endonuclease switching during processing of Okazaki fragments in eukaryotes.	POLD1 POLA2	7.87e-04	12	122	2	11473323
Pubmed	Genetic variation in the base excision repair pathway and bladder cancer risk.	POLD1 LIG1	7.87e-04	12	122	2	17203305
Pubmed	P62/SQSTM1 is a novel leucine-rich repeat kinase 2 (LRRK2) substrate that enhances neuronal toxicity.	HDAC6 LRRK2	7.87e-04	12	122	2	29519959
Pubmed	Phosphoproteomics reveals that Parkinson's disease kinase LRRK2 regulates a subset of Rab GTPases.	LRRK2 OCRL	7.87e-04	12	122	2	26824392
Pubmed	The TAF10-containing TFIID and SAGA transcriptional complexes are dispensable for early somitogenesis in the mouse embryo.	TAF1C TRRAP TAF3	8.21e-04	52	122	3	28893950
Pubmed	The role of oxidative stress in Parkinson's disease.	LRRK2 ATP13A2	9.28e-04	13	122	2	24252804
Pubmed	Genetic cardiovascular risk factors and age-related macular degeneration.	APOB NOS3	9.28e-04	13	122	2	19860767
Pubmed	Tbx6 controls left-right asymmetry through regulation of Gdf1.	GDF1 RFX3	9.28e-04	13	122	2	29650695
Pubmed	The deubiquitinase TRABID stabilizes the K29/K48-specific E3 ubiquitin ligase HECTD1.	POLD1 TRRAP PAN2 HELZ TNKS1BP1	9.34e-04	212	122	5	33853758
Pubmed	Quantitative interaction proteomics and genome-wide profiling of epigenetic histone marks and their readers.	SFPQ TRRAP AHDC1 TAF3	9.77e-04	124	122	4	20850016
Interaction	TOP3B interactions	SRXN1 FRAS1 GBF1 HECTD4 CBLC APOB ITGA3 TRRAP ATP13A2 HDAC7 AHDC1 SYNE4 TFE3 HIRA FOCAD NEK8 SBF2 HPS6 AP1G2 HELZ TNKS1BP1 ESPL1 ALKBH6 PRRT4	2.73e-06	1470	116	24	int:TOP3B
Cytoband	11q13.1	POLA2 SLC22A12 AP5B1 FERMT3	2.50e-05	63	122	4	11q13.1
GeneFamily	Protein phosphatase 1 regulatory subunits\|Histone deacetylases, class IIB	HDAC6 HDAC10	1.65e-05	2	74	2	993
GeneFamily	Parkinson disease associated genes\|ATPase orphan transporters	ATP13A5 ATP13A2	1.64e-04	5	74	2	1213
GeneFamily	Regulatory factor X family	RFX2 RFX3	4.55e-04	8	74	2	1153
GeneFamily	Ankyrin repeat domain containing\|FERM domain containing	EPB41L4B MYO15A FERMT3	1.12e-03	50	74	3	1293
GeneFamily	Parkinson disease associated genes	LRRK2 ATP13A2	1.91e-03	16	74	2	672
GeneFamily	DNA polymerases	POLD1 POLA2	3.95e-03	23	74	2	535
GeneFamily	Armadillo repeat containing\|Protein phosphatase 1 regulatory subunits	SFPQ HDAC6 CAMSAP3 MYO16	6.48e-03	181	74	4	694
GeneFamily	Methyltransferase like	METTL25B METTL16	8.04e-03	33	74	2	963
ToppCell	356C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_0\|CD8+_Cytotoxic_T-cell / Donor, Lineage, Cell class and subclass (all cells)	HEATR5A AHDC1 HIRA SBF2 ARHGAP29 LYL1	2.75e-06	144	121	6	57d2846ec26d4490ec11c171af447b17a729437e
ToppCell	LPS-IL1RA-Myeloid_granulocytic\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	TBXAS1 GBF1 ZCCHC2 RFX2 JAML FBXO2	4.05e-06	154	121	6	d55fb73461885e1e02061a344ff89624ef4de487
ToppCell	LPS-IL1RA-Myeloid_granulocytic-Neutrophils\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	TBXAS1 GBF1 ZCCHC2 RFX2 JAML FBXO2	4.05e-06	154	121	6	43735f7c58cac51855ded486ee8d8729a1b9909e
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FRAS1 APOB ADGRV1 PKD1L2 MYO15A MYO16	1.12e-05	184	121	6	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FRAS1 APOB ADGRV1 PKD1L2 MYO15A MYO16	1.12e-05	184	121	6	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FRAS1 APOB ADGRV1 PKD1L2 MYO15A MYO16	1.12e-05	184	121	6	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	facs-Diaphragm-Limb_Muscle-18m-Lymphocytic\|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	POLD1 POLA2 AP1G2 LYL1 ESPL1 FERMT3	1.23e-05	187	121	6	e53471c3e146a6f54788d81ecc469aba55b051bb
ToppCell	facs-Diaphragm-Limb_Muscle-18m-Lymphocytic-nan\|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	POLD1 POLA2 AP1G2 LYL1 ESPL1 FERMT3	1.23e-05	187	121	6	3d7d51fbadb20dc884d0b3c0d61b80f022b19d09
ToppCell	LPS_IL1RA_TNF-Epithelial_alveolar-AT_2-Differentiating_AT2\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	LRRK2 CAMSAP3 ADGRV1 GK5 NRXN3 AP1G2	1.80e-05	200	121	6	e8db082aa4d0597500e4f16a5c0ea3e62c6c59ae
Disease	juvenile-onset Parkinson's disease (implicated_via_orthology)	ATP13A5 ATP13A2	8.83e-05	4	114	2	DOID:0060893 (implicated_via_orthology)
Disease	Kufor-Rakeb syndrome (implicated_via_orthology)	ATP13A5 ATP13A2	8.83e-05	4	114	2	DOID:0060556 (implicated_via_orthology)
Disease	MiT family translocation renal cell carcinoma	SFPQ TFE3	3.07e-04	7	114	2	C4518356
Disease	uric acid measurement	FRAS1 HECTD4 ADGRV1 POLA2 SLC22A24 SLC22A12 SBF2 SIMC1 VAX2	6.15e-04	610	114	9	EFO_0004761
Disease	N6-acetyllysine measurement	HDAC6 MPDU1	6.52e-04	10	114	2	EFO_0800036
Disease	Varicose veins	ADGRV1 ATP13A2 HDAC7 NEK8 SBF2	9.38e-04	193	114	5	HP_0002619
Disease	liver cirrhosis (implicated_via_orthology)	FOCAD NOS3	1.12e-03	13	114	2	DOID:5082 (implicated_via_orthology)
Disease	putamen volume change measurement	TAF3 MYO16	1.12e-03	13	114	2	EFO_0021495
Disease	alcohol dependence measurement	NRXN3 DBX1 MYO16	1.27e-03	55	114	3	EFO_0007835
Disease	neuronal ceroid lipofuscinosis (implicated_via_orthology)	ATP13A5 ATP13A2	1.31e-03	14	114	2	DOID:14503 (implicated_via_orthology)
Disease	sickle cell anemia (is_implicated_in)	APOB NOS3	1.71e-03	16	114	2	DOID:10923 (is_implicated_in)
Disease	Lipidemias	APOB NOS3	1.94e-03	17	114	2	C1706412
Disease	Hyperlipidemia	APOB NOS3	1.94e-03	17	114	2	C0020473
Disease	transient cerebral ischemia (implicated_via_orthology)	DAXX MFF NOS3	1.97e-03	64	114	3	DOID:224 (implicated_via_orthology)
Disease	urinary metabolite measurement	NPHS1 SLC22A24 DGLUCY HDAC10 MYO16	2.67e-03	245	114	5	EFO_0005116
Disease	electroencephalogram measurement	FOCAD DBX1 MYO16	2.98e-03	74	114	3	EFO_0004357
Disease	portal hypertension (biomarker_via_orthology)	NOS3 CPEB1	3.25e-03	22	114	2	DOID:10762 (biomarker_via_orthology)
Disease	Parkinson disease	LRRK2 ATP13A2	3.25e-03	22	114	2	cv:C0030567
Disease	Parkinson's disease (implicated_via_orthology)	HDAC6 ATP13A5 ATP13A2 PTPRN	3.27e-03	157	114	4	DOID:14330 (implicated_via_orthology)
Disease	Ovarian Serous Adenocarcinoma	LRRK2 TRRAP	3.55e-03	23	114	2	C1335177
Disease	epilepsy (implicated_via_orthology)	ITGA3 SLC13A1 SBF2 NOS3	3.74e-03	163	114	4	DOID:1826 (implicated_via_orthology)
Disease	Nonsyndromic Deafness	ADGRV1 SYNE4 MYO15A	3.85e-03	81	114	3	C3711374
Disease	nephrotic syndrome (biomarker_via_orthology)	NPHS1 APOB	3.86e-03	24	114	2	DOID:1184 (biomarker_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
PRPTTSLLLEPRSLL	ALKBH6	156	Q3KRA9
RLPLRALPLDPSLSL	CCDC17	511	Q96LX7
ILLTVTVPPVLPAAL	ATP13A5	436	Q4VNC0
LLRSLLPPPLLSAGA	C9orf50	96	Q5SZB4
PPSLRDLLPRTAQLL	CBLC	41	Q9ULV8
LTSLLLLAEPLPRPR	BTBD6	16	Q96KE9
TVELLNIIPLIPPIS	ADGRV1	616	Q8WXG9
RPPENPALLLITITA	AP1G2	686	O75843
LLPRLPSEPGMTLLT	AIDA	156	Q96BJ3
LTLSPVPRDSLLPLQ	AHDC1	1546	Q5TGY3
PAELRLAPLTRVLTP	CAMSAP3	786	Q9P1Y5
RIVSPSLLSEEPLAP	DAXX	526	Q9UER7
ELVSPRVILSILVPP	NPHS1	121	O60500
DLLPLSLIPVPLTTD	PAN2	391	Q504Q3
SSLSPLQAELLPPLL	PTPRN	171	Q16849
SLILPAPPIVVTLAD	FRAS1	3156	Q86XX4
LPSLPLEPSLLSGVV	LRP10	641	Q7Z4F1
PIQIPSRLPLLLTHE	LONP2	6	Q86WA8
ASPLLLLLLVPSPRL	MCUR1	66	Q96AQ8
LLLLVPSPRLAAAAP	MCUR1	71	Q96AQ8
PPRVLTLSERPLDFL	MFF	116	Q9GZY8
PILPAQLLEVLSSPT	SBF2	256	Q86WG5
LTVPLRTPLTQLPAE	MYO15A	2066	Q9UKN7
DLPVLSSKLSPLVLP	MYO16	336	Q9Y6X6
QLLPALSTLPRLTTL	LRRC75A	221	Q8NAA5
LLALLLPSLPLTRAP	GDF1	16	P27539
PEPLLLRVLAALPAA	FBXO2	51	Q9UK22
TPPRTQEVTPLLLEL	ISM2	176	Q6H9L7
TLVVPPALLLSSVRP	ITGA3	676	P26006
LLRSLGVVLPTPLLL	OR51L1	151	Q8NGJ5
LLRPTPTLTLPQSLQ	DBX1	16	A6NMT0
ITLPPTFRPLLTIIE	NRXN3	1361	Q9Y4C0
LSLLSLEPAQRPPLS	NEK8	236	Q86SG6
PRLTIPISQIAPDLI	LRRK2	1846	Q5S007
LSIDIPLERLIPTVP	METTL16	66	Q86W50
PTLLGPLQTPLRVLD	LRRC14B	296	A6NHZ5
LPPATAPLLARLLAL	AMH	396	P03971
LLPIFSPELSPRNLV	METTL25B	441	Q96FB5
TSLLDTLVLLPPRPS	AP5B1	76	Q2VPB7
RSPPILPTLDSLKTL	MTPAP	391	Q9NVV4
IRADVPLPLDLLPSF	HECTD4	3711	Q9Y4D8
LAITTPLAIQLPPVL	HELZ	651	P42694
PSPLRVLLGTSLTIP	ACAN	36	P16112
LPPPDSAVTLRLAVL	PKD1L2	626	Q7Z442
ASPRVLTPTLALTLP	KCNJ14	421	Q9UNX9
TSPPSPQLLRLLSTL	NOS3	866	P29474
RPVSLPVDRLLLASP	ARHGAP29	1016	Q52LW3
RVPSYTLILPSLELP	APOB	3291	P04114
TLILPSLELPVLHVP	APOB	3296	P04114
RPPGALLSVPVLSSL	ATP13A2	991	Q9NQ11
VPVQPLLPESLARSL	FBF1	541	Q8TES7
PPSLVPSLLDEILAQ	ESPL1	1211	Q14674
LTTPDITLVLPPDVI	HDAC10	416	Q969S8
LLTEEVTQRLLPPLP	HEATR5A	626	Q86XA9
PTLSLVLTLLLTVPP	HEATR5B	976	Q9P2D3
PDSLITLVQPELPTL	HEATR5B	1466	Q9P2D3
LTLPRSLLLEPPRGT	KLHL22	591	Q53GT1
SLPDALLPNLLDRTP	DOCK7	201	Q96N67
VSRVLLLLLLQPPPA	F8A1;	271	P23610
VPIPSLDRAASPVLL	ELK3	386	P41970
PTTELGTLRPPLLQL	LYL1	76	P12980
ILLPSSILPEAISLL	ITIH6	986	Q6UXX5
LPIILNPALIEATSP	GBF1	1826	Q92538
SLISIPLSLLPPVRD	GK5	236	Q6ZS86
VLSPFILTLPPEDRL	KLHDC7B	576	Q96G42
LISSLRISPPLPFLS	CPEB1	201	Q9BZB8
LREAPPSPLTSLALL	EMILIN3	286	Q9NT22
PETPLPSVLLAVELL	ATRIP	596	Q8WXE1
LTLPRPPLSGALASI	HDAC6	806	Q9UBN7
PTVSLLPAITLGLPA	HDAC7	246	Q8WUI4
TLPSRLQPILLLDPS	HDAC7	301	Q8WUI4
RLLSPILLPSPISTL	HIRA	766	P54198
LRPASLVVLPRSLAP	DGLUCY	36	Q7Z3D6
PPELAPAELLLLLRT	HPS6	696	Q86YV9
LRSVVALSPPDLLPV	LIG1	316	P18858
LLLTLLTPIVPSNSL	ERVFC1	11	P60507
AALLLPETQSLPLPD	SLC22A12	511	Q96S37
PATITLFLPILSPLA	SLC13A1	491	Q9BZW2
PLIPAATLRPLTETV	EPB41L4B	846	Q9H329
PSPFLRITVALPRLV	POLD1	206	P28340
PLSLLPTRSGVLTIP	MAP3K19	211	Q56UN5
KLLSLTPPLVLPALE	FOCAD	761	Q5VW36
LPTLIALTTLLLPIS	MT-ND2	326	P03891
ALAPSPVIPRLTLRV	TAF3	751	Q5VWG9
PDPASRQPLTFLLIL	SYNE4	346	Q8N205
VILLLPETRDLPLPN	SLC22A24	511	Q8N4F4
TVPPDVPAATRTLLL	LRTM2	61	Q8N967
VAEPRLPLSPIITLE	NHSL2	1026	Q5HYW2
EILIPDVLRPVPSTL	RFX2	456	P48378
EILIPDVLRPIPSAL	RFX3	441	P48380
LPSRIDSLPAFPLLE	TAF1C	536	Q15572
PRTLVTPAALRPLVL	JAML	256	Q86YT9
TLPPTFRPLLTIIET	NRXN3	356	Q9HDB5
ATLPLQDSPLLATLP	PRR36	516	Q9H6K5
SPLSILLTLDVELPP	PTTG3P	181	Q9NZH4
KPSDLILTRLLVPPL	POLR3A	246	O14802
ILTRLLVPPLCIRPS	POLR3A	251	O14802
RPIATLDLTLEPVTP	SIMC1	56	Q8NDZ2
TLRPPTILPTLRSAL	TEKT5	71	Q96M29
PRIFSLLVPTALPLL	TAP1	41	Q03518
LSEVLDTPLLPRLLP	CCT8L1P	326	A6NM43
LSEVLDTPLLPRLLP	CCT8L2	326	Q96SF2
TLVPTPALARIPRLV	SELENOV	71	P59797
LPVTPDVLIIPSELR	POLA2	531	Q14181
FTLPLLSVLVILPLS	SLC38A8	151	A6NNN8
LLVLLSPLTPLTVVT	MPDU1	141	O75352
ATLFTSLLLRPPPNL	OCRL	861	Q01968
ILLLSIIRARPPPFL	TEPP	11	Q6URK8
LELLASPLPIPSTFL	ZCCHC2	786	Q9C0B9
LLLALTPLLSSEPPF	RHBDD3	151	Q9Y3P4
FLLTTTPRPVIVEPL	SFPQ	436	P23246
SASRDVLPRTLLLPP	RINL	126	Q6ZS11
IPRPILVLLLSFPSI	TBXAS1	221	P24557
VLPLSRPSVPDVLAT	TRPM6	1361	Q9BX84
PLPLRSSLPISLQAT	TFE3	71	P19532
AQVSTLLTLLPPPVL	TRAPPC14	211	Q8WVR3
PLDLLPSLPRESQIF	RNF222	136	A6NCQ9
PPLILSPDLITTLAD	SPATA31D1	196	Q6ZQQ2
LSVLIRPLPSVLDPA	SRXN1	46	Q9BYN0
SLDTPSRPLALPLVE	RNF10	436	Q8N5U6
SPLPLATREAALPIL	TNKS1BP1	601	Q9C0C2
TVLLATPEPPRRLLL	TMEM102	301	Q8N9M5
SEEVLSLLRAIPPIP	TLE7	121	A0A1W2PR48
TLPLLPSLRASLAEI	PRRT4	196	C9JH25
IALEPPRTSPNLLLA	RPS6KL1	276	Q9Y6S9
DPLLLQRLPRPSSLS	FERMT3	206	Q86UX7
LSPALTESLLVALPP	UPK2	36	O00526
LLSVPRAPSLLALTP	VAX2	191	Q9UIW0
RAPSLLALTPSLPGL	VAX2	196	Q9UIW0
APSRTLLLALPLPLS	PRSS50	366	Q9UI38
LTVPVRLSSLLPYLP	TRRAP	811	Q9Y4A5
LSPLTPARLLGPSLT	SMTN	356	P53814