Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	IBR	CUL9 RNF216	3.61e-04	14	38	2	SM00647
Domain	IBR_dom	CUL9 RNF216	4.16e-04	15	38	2	IPR002867
Domain	MAGE	MAGED4 MAGEC2	2.17e-03	34	38	2	SM01373
Domain	MAGE	MAGED4 MAGEC2	2.43e-03	36	38	2	PS50838
Domain	MHD_dom	MAGED4 MAGEC2	2.43e-03	36	38	2	IPR002190
Domain	MAGE	MAGED4 MAGEC2	2.43e-03	36	38	2	PF01454
Pubmed	MAGE-E1, a new member of the melanoma-associated antigen gene family and its expression in human glioma.	MAGED4 MAGEC2	3.67e-06	3	39	2	11406556
Pubmed	Structural characterization and chromosomal localization of the MAGE-E1 gene.	MAGED4 MAGEC2	3.67e-06	3	39	2	11602350
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	ZNF638 TPR CUL9 CHERP BAZ2A PABPC1 CNOT1	7.27e-06	653	39	7	22586326
Pubmed	The interactions of GW182 proteins with PABP and deadenylases are required for both translational repression and degradation of miRNA targets.	PABPC1 CNOT1	7.34e-06	4	39	2	23172285
Pubmed	A human immune dysregulation syndrome characterized by severe hyperinflammation with a homozygous nonsense Roquin-1 mutation.	RC3H2 CNOT1	7.34e-06	4	39	2	31636267
Pubmed	Roquin promotes constitutive mRNA decay via a conserved class of stem-loop recognition motifs.	RC3H2 PABPC1 CNOT1	1.79e-05	45	39	3	23663784
Pubmed	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.	ZNF638 RC3H2 CHERP RSRC2 TCERG1 PABPC1 CNOT1	2.84e-05	807	39	7	22681889
Pubmed	miRNA-mediated deadenylation is orchestrated by GW182 through two conserved motifs that interact with CCR4-NOT.	PABPC1 CNOT1	5.48e-05	10	39	2	21984185
Pubmed	miRNA repression involves GW182-mediated recruitment of CCR4-NOT through conserved W-containing motifs.	PABPC1 CNOT1	6.70e-05	11	39	2	21984184
Pubmed	O-GlcNAcylated LARP1 positively regulated by circCLNS1A facilitates hepatoblastoma progression through DKK4/β-catenin signalling.	PABPC1 CNOT1	9.48e-05	13	39	2	37070251
Pubmed	The arginine methyltransferase CARM1 regulates the coupling of transcription and mRNA processing.	TCERG1 PABPC1	9.48e-05	13	39	2	17218272
Pubmed	GW182 proteins directly recruit cytoplasmic deadenylase complexes to miRNA targets.	PABPC1 CNOT1	1.27e-04	15	39	2	21981923
Pubmed	Screening and association testing of common coding variation in steroid hormone receptor co-activator and co-repressor genes in relation to breast cancer risk: the Multiethnic Cohort.	NCOA1 CALCOCO1	1.65e-04	17	39	2	19183483
Pubmed	Mapping the Ku Interactome Using Proximity-Dependent Biotin Identification in Human Cells.	ZNF638 TPR TCERG1 BAZ2A	2.82e-04	283	39	4	30585729
Pubmed	Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.	TPR CUL9 RSRC2 TCERG1 PRDM15 MEF2A	3.58e-04	857	39	6	25609649
Pubmed	Comparative interactome analysis of α-arrestin families in human and Drosophila.	ZNF638 CUL9 CHERP MAGED4	4.13e-04	313	39	4	38270169
Pubmed	KSHV episome tethering sites on host chromosomes and regulation of latency-lytic switch by CHD4.	ZNF638 CHERP RSRC2	4.23e-04	130	39	3	35545047
Pubmed	Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.	ZNF638 TPR SHROOM3 CHERP CNOT1	4.64e-04	582	39	5	20467437
Pubmed	Interactions of the Antiviral Factor Interferon Gamma-Inducible Protein 16 (IFI16) Mediate Immune Signaling and Herpes Simplex Virus-1 Immunosuppression.	ZNF638 DHX33 BAZ2A CNOT1	5.15e-04	332	39	4	25693804
Pubmed	H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.	ZNF638 DHX33 CHERP ACTL8 CDC40 TCERG1 BAZ2A	5.26e-04	1294	39	7	30804502
Pubmed	Mammalian APE1 controls miRNA processing and its interactome is linked to cancer RNA metabolism.	ZNF638 TBC1D25 ECSIT PABPC1 MEF2A USP19	5.37e-04	925	39	6	28986522
Pubmed	PRP19 transforms into a sensor of RPA-ssDNA after DNA damage and drives ATR activation via a ubiquitin-mediated circuitry.	ZNF638 CHERP TCERG1 PABPC1	5.63e-04	340	39	4	24332808
Pubmed	N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.	ZNF638 TPR CHERP TCERG1 BAZ2A PABPC1	5.65e-04	934	39	6	33916271
Pubmed	The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.	ZNF638 TPR CHERP TCERG1 BAZ2A PABPC1	6.31e-04	954	39	6	36373674
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	ZNF638 TPR DHX33 CDC40 TCERG1 BAZ2A PABPC1	6.85e-04	1353	39	7	29467282
Pubmed	WW domains provide a platform for the assembly of multiprotein networks.	CHERP TCERG1 PABPC1	6.92e-04	154	39	3	16055720
Pubmed	The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation.	CHERP TCERG1 PABPC1 CNOT1 USP19	7.03e-04	638	39	5	33239621
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	ZNF638 RNF216 RC3H2 CDC40 TCERG1	7.64e-04	650	39	5	38777146
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	TPR CHERP CDC40 TCERG1 PABPC1 CNOT1 USP19	9.29e-04	1425	39	7	30948266
Pubmed	Human transcription factor protein interaction networks.	ZNF638 NCOA1 CUL9 TCERG1 PABPC1 CNOT1 MEF2A	9.45e-04	1429	39	7	35140242
Pubmed	Spatiotemporal-resolved protein networks profiling with photoactivation dependent proximity labeling.	TPR CHERP TCERG1 PABPC1	1.02e-03	399	39	4	35987950
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	DGKB CUL9 BAZ2A USP19	1.10e-03	407	39	4	12693553
Interaction	SNW1 interactions	CCDC125 ZNF638 TPR NCOA1 SHROOM3 CHERP CDC40 USB1 PABPC1 CNOT1	6.47e-07	747	37	10	int:SNW1
Interaction	CDC5L interactions	ZNF638 TPR RC3H2 SHROOM3 CHERP CDC40 USB1 PABPC1 CNOT1	1.82e-05	855	37	9	int:CDC5L
Cytoband	16q21	USB1 CNOT1	6.80e-04	45	39	2	16q21
Cytoband	Ensembl 112 genes in cytogenetic band chr16q21	USB1 CNOT1	2.08e-03	79	39	2	chr16q21
Cytoband	6q21	FAM229B CDC40	3.05e-03	96	39	2	6q21
Cytoband	Ensembl 112 genes in cytogenetic band chr6q21	FAM229B CDC40	4.79e-03	121	39	2	chr6q21
GeneFamily	MAGE family	MAGED4 MAGEC2	1.50e-03	40	26	2	1136
Computational	RNA splicing.	ZNF638 CHERP PABPC1	2.24e-04	65	20	3	MODULE_183
Drug	Meclofenamic acid sodium salt monohydrate [6385-02-0]; Down 200; 11.8uM; PC3; HT_HG-U133A	TPR CUL9 RC3H2 BAZ2A MEF2A CALCOCO1	7.33e-07	192	38	6	7280_DN
Drug	SB 203580; Up 200; 1uM; PC3; HT_HG-U133A	NCOA1 RNF216 BAZ2A MEF2A USP19	1.83e-05	197	38	5	7066_UP
Drug	Harmalol hydrochloride dihydrate [6028-07-5]; Down 200; 14.6uM; MCF7; HT_HG-U133A	TPR NCOA1 RNF216 USB1 BAZ2A	1.88e-05	198	38	5	5495_DN
Drug	Phentolamine hydrochloride [73-05-2]; Down 200; 12.6uM; HL60; HT_HG-U133A	NCOA1 RNF216 RC3H2 BAZ2A USP19	1.88e-05	198	38	5	2362_DN
Drug	Meropenem [96036-03-2]; Down 200; 10.4uM; MCF7; HT_HG-U133A	CUL9 RNF216 ACTL8 USB1 BAZ2A	1.93e-05	199	38	5	3564_DN
Disease	ghrelin measurement	DGKB ARGFX	1.73e-03	49	37	2	EFO_0600001
Disease	cognitive behavioural therapy	ACTL8 TCERG1	2.42e-03	58	37	2	EFO_0007820
Disease	fish consumption measurement	DGKB CNOT1	2.94e-03	64	37	2	EFO_0010139
Disease	citrate measurement	SHROOM3 CNOT1	4.44e-03	79	37	2	EFO_0010114

Protein segments in the cluster

Peptide	Gene	Start	Entry
MPFQFGTQPRRFPVE	FAM229B	1	Q4G0N7
PEMFFSPQVFEQPGP	ACTL8	256	Q9H568
FPDQNFEVMPNGPPS	BAZ2A	171	Q9UIF9
MRNRMAPENPQPDPF	ARGFX	1	A6NJG6
FSPRDRMNSSPYQPP	RC3H2	661	Q9HBD1
PFQNMPGAIRPAAPR	PABPC1	446	P11940
RIPPGDPMFDPDQRG	DUOX1	126	Q9NRD9
TMGPFGPQDQRFQLP	MMADHC	61	Q9H3L0
MPPVPGVPFRNVDND	MAGEC2	1	Q9UBF1
GMAFPRPKRPAPAQE	MAGED4	246	Q96JG8
GPKPDSRMQEFFQPP	LMOD3	436	Q0VAK6
FIFPAPTNGEPMRPG	GGN	416	Q86UU5
PISPPRDRMTPSGFQ	MEF2A	406	Q02078
MPGNPPRLPFNDPFF	KCNA7	196	Q96RP8
NFSPPPFPRKGEERN	CCDC125	56	Q86Z20
FMQDDFPPRHPFERP	CHERP	551	Q8IWX8
FENKRPDPFPMPTFA	CALHM5	246	Q8N5C1
PMPGLNFFRDVPDFR	DGKB	476	Q9Y6T7
MPEEAGFPPAKRFRP	DHX33	1	Q9H6R0
QGMSPPRPTRSIFQP	CUL9	326	Q8IWT3
GQSPPFQFREPRPMD	CALCOCO1	111	Q9P1Z2
RFMNVNPFPVPRDLP	ECSIT	206	Q9BQ95
PSPPPFRGRNTAMDA	RSRC2	221	Q7L4I2
PPPQEFGRGNPFMLF	TBC1D25	606	Q3MII6
GLATRPRMPNNSFPP	NCOA1	496	Q15788
MPRRRPPASGAAQFP	PRDM15	1	P57071
ETMFAPEFGPENPFR	CDC40	86	O60508
PEFGPENPFRTQQMA	CDC40	91	O60508
EPAPLGPQRNGMRFP	SHROOM3	1036	Q8TF72
PVRPVFNNFPLNMGP	RNF216	811	Q9NWF9
FPRNMRLPDPFTPNL	CNOT1	2136	A5YKK6
MPPQQGDPAFPDRCE	RHOU	1	Q7L0Q8
FQPPFQPGRMALESQ	USP19	871	O94966
ALRFRGPAPPPNAVM	TCERG1	26	O14776
VPRFRFGPPEDMPQT	TPR	2161	P12270
GRFEPQGLQLMPNPF	TEX52	216	A6NCN8
QRFPVPDSVLNMFPG	USB1	41	Q9BQ65
EQPQFSPMPGNVRRP	MST1R	1376	Q04912
DFPLQRPRAPNPSGM	ZNF638	11	Q14966
EQGSPQNGAPRPMRF	ZAR1	161	Q86SH2