Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyBiologicalProcessregulation of motor neuron apoptotic process

VPS54 MAP3K12 KCNB1 AGRN

1.65e-05201634GO:2000671
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

SETD1A SHROOM3 SZT2 SREBF1 HIP1R DYRK1A NBL1 SPATA20 CARD10 CEP192 RYR1 KMT2C MDN1 EIF4ENIF1 MROH1 SYNJ1 INF2 NBEAL2 SCN5A PLEC HERC2 GCN1 AGRN WNK2 IQCE SYMPK

2.66e-1111051682635748872
Pubmed

The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.

KPNA4 SHROOM3 VPS72 ATRX GEMIN2 PDZK1 HIP1R DYRK1A CGGBP1 NDUFV1 GATAD2B GREB1L KIAA1671 KMT2C MDN1 EIF4ENIF1 CLPB TRIM32 FAM120C LNPEP TPX2 MACF1 ISG20L2 KIF2A HERC2 AGRN

1.58e-0814971682631527615
Pubmed

Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.

KPNA4 DMTF1 SETD1A SHROOM3 PDCD6IP KDM5D KIAA1671 EIF4ENIF1 ZNF532 TPX2 PLEC WNK2 IQCE

1.97e-074301681335044719
Pubmed

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.

SHROOM3 PDCD6IP DYRK1A SPATA20 GATAD2B EEF2 MDN1 FAM120A ZNF394 KCNB1 SYNJ1 FAM120C KCNJ16 MACF1 KIF2A SSH2 HERC2 AGRN WNK2

2.40e-079631681928671696
Pubmed

Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism.

KPNA4 SCO2 RASGRP4 MASP1 PDCD6IP VPS72 ATRX SZT2 RBL2 SREBF1 DYRK1A VPS54 CGGBP1 PRUNE1 KMT2C SMG8 CLPB PLEKHA3 PGLS SSH2 GCN1

1.91e-0613271682132694731
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

SETD1A RELCH SHROOM3 PDCD6IP SZT2 TRIM35 HIP1R KMT2C PPP2R2A ZNF532 NBEAL2 WNK2 IQCE

2.00e-065291681314621295
Pubmed

The MYO6 interactome reveals adaptor complexes coordinating early endosome and cytoskeletal dynamics.

SHROOM3 DOCK8 CARD10 CEP192 SYNJ1 FAM120C LNPEP

2.68e-06125168729467281
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

SHROOM3 PDCD6IP ATRX EPB41L4B FAM53A TTC21A BLNK CEP192 VPS54 MAP3K12 KIAA1671 PLEKHH1 KMT2C PPP2R2A FAM120A ZNF532 INF2 FAM120C MACF1 ASPSCR1 GLIS1 WNK2

3.25e-0614891682228611215
Pubmed

Toll-like receptors activate programmed necrosis in macrophages through a receptor-interacting kinase-3-mediated pathway.

TICAM1 TLR3 TNFRSF1A

3.82e-067168322123964
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

KPNA4 CFH VPS72 ATRX RBL2 DYRK1A VPS54 PLEKHH1 EEF2 FAM120A FBH1 CLPB SYNJ1 ZNF532 TRIM32 MACF1 PLEC HERC2 CCDC24 PCCB

4.39e-0612851682035914814
Pubmed

Identification of SUMO Binding Proteins Enriched after Covalent Photo-Cross-Linking.

PDCD6IP ATRX GATAD2B EEF2 MDN1 TPX2 KIF2A PLEC GCN1 SYMPK

5.45e-063321681032786267
Pubmed

Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.

SHROOM3 PDCD6IP ATRX DOCK8 HIP1R CARD10 MDN1 FAM120C TPX2 MACF1 PLEC GCN1 SYMPK

5.64e-065821681320467437
Pubmed

Rip1 mediates the Trif-dependent toll-like receptor 3- and 4-induced NF-{kappa}B activation but does not contribute to interferon regulatory factor 3 activation.

TICAM1 TLR3 TNFRSF1A

6.09e-068168316115877
Pubmed

CLEC16A interacts with retromer and TRIM27, and its loss impairs endosomal trafficking and neurodevelopment.

SZT2 HIP1R DYRK1A KIAA1671 PPP2R2A VPS13D MDN1 PMPCA DYRK1B NUP133 KIF2A HERC2 PCCB

8.68e-066061681336538041
Pubmed

The functional interactome landscape of the human histone deacetylase family.

KPNA4 GEMIN2 GATAD2B PPP2R2A MDN1 CLPB TPX2 NUP133 GCN1

1.25e-05289168923752268
Pubmed

TEM8 marks neovasculogenic tumor-initiating cells in triple-negative breast cancer.

TRIM35 EEF2 ASB10 SMAD5

1.31e-0530168434285210
Pubmed

USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma.

DNHD1 OVCH1 EEF2 MDN1 FAM120C TPX2 MACF1 PLEC

1.97e-05234168836243803
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

SHROOM3 PDCD6IP DYRK1A CEP192 KIAA1671 USP31 VPS13D MDN1 SYNJ1 PLEKHA3 DYRK1B MACF1 KIF2A SSH2 PLEC

2.05e-058611681536931259
Pubmed

KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.

PDCD6IP EPB41L4B DOCK8 TTC21A DYRK1A NDUFV1 USP31 PPP2R2A CPNE6 EEF2 FAM120A SYNJ1 INF2 FAM120C AJM1 MACF1 KIF2A SSH2 PLEC WNK2

2.09e-0514311682037142655
Pubmed

Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.

DMTF1 SALL3 PDCD6IP ATRX EPB41L4B FAM210A DYRK1A CEP192 FAM171B KMT2C INTS14 SYNJ1 INF2 MACF1 KIF2A PLEC AGRN

2.18e-0510841681711544199
Pubmed

Butyrophilin-like 1 encodes an enterocyte protein that selectively regulates functional interactions with T lymphocytes.

BTNL8 BTNL3

2.32e-052168221368163
Pubmed

Analysis of a TIR-less splice variant of TRIF reveals an unexpected mechanism of TLR3-mediated signaling.

TICAM1 TLR3

2.32e-052168220200155
Pubmed

Contact activation-induced complex formation between complement factor H and coagulation factor XIIa.

CFH F12

2.32e-052168231984663
Pubmed

TLR-TRIF pathway enhances the expression of KSHV replication and transcription activator.

TICAM1 TLR3

2.32e-052168223723066
Pubmed

A butyrophilin family member critically inhibits T cell activation.

BTNL8 BTNL3

2.32e-052168220944003
Pubmed

Toll-like receptor 3 activation is required for normal skin barrier repair following UV damage.

TICAM1 TLR3

2.32e-052168225118157
Pubmed

Role of extracellular RNA and TLR3-Trif signaling in myocardial ischemia-reperfusion injury.

TICAM1 TLR3

2.32e-052168224390148
Pubmed

Age-dependent TLR3 expression of the intestinal epithelium contributes to rotavirus susceptibility.

TICAM1 TLR3

2.32e-052168222570612
Pubmed

The ontogeny of Butyrophilin-like (Btnl) 1 and Btnl6 in murine small intestine.

BTNL8 BTNL3

2.32e-052168227528202
Pubmed

Targeting poly(I:C) to the TLR3-independent pathway boosts effector CD8 T cell differentiation through IFN-alpha/beta.

TICAM1 TLR3

2.32e-052168219017955
Pubmed

Suppression of DYRK1A/B Drives Endoplasmic Reticulum Stress-mediated Autophagic Cell Death Through Metabolic Reprogramming in Colorectal Cancer Cells.

DYRK1A DYRK1B

2.32e-052168234969768
Pubmed

Gene expression profiling of ameloblastoma and human tooth germ by means of a cDNA microarray.

FOS TNFRSF1A

2.32e-052168212147741
Pubmed

Negative control of TLR3 signaling by TICAM1 down-regulation.

TICAM1 TLR3

2.32e-052168222205631
Pubmed

Human cytomegalovirus utilises cellular dual-specificity tyrosine phosphorylation-regulated kinases during placental replication.

DYRK1A DYRK1B

2.32e-052168230501876
Pubmed

Defined TLR3-specific adjuvant that induces NK and CTL activation without significant cytokine production in vivo.

TICAM1 TLR3

2.32e-052168225692975
Pubmed

Loss of TLR3 and its downstream signaling accelerates acinar cell damage in the acute phase of pancreatitis.

TICAM1 TLR3

2.32e-052168230583980
Pubmed

Toll-like receptor 3-mediated suppression of TRAMP prostate cancer shows the critical role of type I interferons in tumor immune surveillance.

TLR3 TNFRSF1A

2.32e-052168220233880
Pubmed

Enterovirus 68 3C protease cleaves TRIF to attenuate antiviral responses mediated by Toll-like receptor 3.

TICAM1 TLR3

2.32e-052168224672048
Pubmed

Double-stranded RNA exacerbates pulmonary allergic reaction through TLR3: implication of airway epithelium and dendritic cells.

TICAM1 TLR3

2.32e-052168220505141
Pubmed

Sall3 correlates with the expression of TH in mouse olfactory bulb.

SALL3 TH

2.32e-052168221701790
Pubmed

Cell type-specific spatial and functional coupling between mammalian brain Kv2.1 K+ channels and ryanodine receptors.

RYR1 KCNB1

2.32e-052168224962901
Pubmed

Fos expression in tyrosine hydroxylase containing hypothalamic neurons in CRH-KO mice: effect of immobilization stress.

FOS TH

2.32e-052168220799851
Pubmed

FAM120A couples SREBP-dependent transcription and splicing of lipogenesis enzymes downstream of mTORC1.

SREBF1 FAM120A

2.32e-052168237595559
Pubmed

TICAM-1, an adaptor molecule that participates in Toll-like receptor 3-mediated interferon-beta induction.

TICAM1 TLR3

2.32e-052168212539043
Pubmed

Genetically engineered fusion of MAP-1 and factor H domains 1-5 generates a potent dual upstream inhibitor of both the lectin and alternative complement pathways.

CFH MASP1

2.32e-052168226260032
Pubmed

Disruption of TLR3 signaling due to cleavage of TRIF by the hepatitis A virus protease-polymerase processing intermediate, 3CD.

TICAM1 TLR3

2.32e-052168221931545
Pubmed

Regulation of the voltage-gated K+ channel KCNA10 by KCNA4B, a novel beta-subunit.

KCNA10 POMP

2.32e-052168212060596
Pubmed

Identification and functional characterization of transcriptional activators in human cells.

KPNA4 PDCD6IP GEMIN2 RBL2 DYRK1A MRPL45 GATAD2B KMT2C SYNJ1 DYRK1B

2.60e-053981681035016035
Pubmed

Dynamic patterns of histone H3 lysine 4 methyltransferases and demethylases during mouse preimplantation development.

SETD1A KDM5D KMT2C

3.06e-0513168324619213
Pubmed

Functional proteomics mapping of a human signaling pathway.

DMTF1 PDCD6IP ATRX DOCK8 SOX13 GATAD2B CLPB LNPEP MACF1 PLEC HERC2 SMAD5

3.32e-055911681215231748
Pubmed

Squalene emulsion-based vaccine adjuvants stimulate CD8 T cell, but not antibody responses, through a RIPK3-dependent pathway.

TICAM1 TLR3 SIGLEC1

3.88e-0514168332515732
Pubmed

Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.

RELCH PDCD6IP HIP1R FAM171B NDUFV1 GATAD2B PRUNE1 KCNB1 SYNJ1 FAM120C AJM1 MACF1 KIF2A PLEC PCCB GCN1 WNK2

4.05e-0511391681736417873
Pubmed

RNF43 inhibits WNT5A-driven signaling and suppresses melanoma invasion and resistance to the targeted therapy.

EPB41L4B FAM171B KIAA1671 AP4E1 EIF4ENIF1 NUP133 MACF1 GCN1

4.51e-05263168834702444
Pubmed

Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.

KPNA4 PMS1 RELCH CEP192 FAM171B PTPRT KIAA1671 USP31 PPP2R2A PMPCA LNPEP NUP133 SSH2 HERC2 GCN1 SYMPK

5.34e-0510491681627880917
Pubmed

Identification of host proteins required for HIV infection through a functional genomic screen.

GEMIN2 HIP1R EFHC2 PPP2R2A MDN1 FBH1 PLEKHA3 NUP133

5.71e-05272168818187620
Pubmed

Sall3 is required for the terminal maturation of olfactory glomerular interneurons.

SALL3 FOS TH

5.92e-0516168318260139
Pubmed

Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.

SETD1A VPS72 ATRX DYRK1A SMG8 CLPB TPX2 NUP133 KIF2A HERC2

6.04e-054401681034244565
Pubmed

Compartmentalization of the SUMO/RNF4 pathway by SLX4 drives DNA repair.

PMS1 PDCD6IP ATRX DYRK1A GATAD2B PPP2R2A EEF2 GCN1 SYMPK

6.47e-05357168937059091
Pubmed

E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.

SCO2 EPB41L4B TTC21A CHN1 RYR1 KIAA1671 KMT2C OTC MDN1 FAM120C TLR3 IQCE SYMPK

6.48e-057361681329676528
Pubmed

MUC1 regulates epithelial inflammation and apoptosis by PolyI:C through inhibition of Toll/IL-1 receptor-domain-containing adapter-inducing IFN-β (TRIF) recruitment to Toll-like receptor 3.

TICAM1 TLR3

6.94e-053168224693944
Pubmed

TAK1 regulates hepatic lipid homeostasis through SREBP.

SREBF1 TNFRSF1A

6.94e-053168226973245
Pubmed

Coordinated Regulation of Vasopressin Inactivation and Glucose Uptake by Action of TUG Protein in Muscle.

LNPEP ASPSCR1

6.94e-053168225944897
Pubmed

Identification of TLT2 as an engulfment receptor for apoptotic cells.

TICAM1 TLR3

6.94e-053168222573805
Pubmed

Immune Sensing of Aeroallergen-Associated Double-Stranded RNA Triggers an IFN Response and Modulates Type 2 Lung Inflammation.

TICAM1 TLR3

6.94e-053168231562213
Pubmed

Down regulation of TRIF, TLR3, and MAVS in HCV infected liver correlates with the outcome of infection.

TICAM1 TLR3

6.94e-053168228480979
Pubmed

Sensing and signaling of immunogenic extracellular RNAs restrain group 2 innate lymphoid cell-driven acute lung inflammation and airway hyperresponsiveness.

TICAM1 TLR3

6.94e-053168232730309
Pubmed

Toll/IL-1 domain-containing adaptor inducing IFN-β (TRIF) mediates innate immune responses in murine peritoneal mesothelial cells through TLR3 and TLR4 stimulation.

TICAM1 TLR3

6.94e-053168226579632
Pubmed

Association between polymorphisms in TLR3, TICAM1 and IFNA1 genes and covid-19 severity in Southern Brazil.

TICAM1 TLR3

6.94e-053168238864429
Pubmed

TRIM56 is an essential component of the TLR3 antiviral signaling pathway.

TICAM1 TLR3

6.94e-053168222948160
Pubmed

Activation of TLR3 and its adaptor TICAM-1 increases miR-21 levels in extracellular vesicles released from human cells.

TICAM1 TLR3

6.94e-053168229679565
Pubmed

Alix and ALG-2 are involved in tumor necrosis factor receptor 1-induced cell death.

PDCD6IP TNFRSF1A

6.94e-053168218936101
Pubmed

Proline Hydroxylation Primes Protein Kinases for Autophosphorylation and Activation.

DYRK1A DYRK1B

6.94e-053168232640193
Pubmed

Sterile inflammation via TRPM8 RNA-dependent TLR3-NF-kB/IRF3 activation promotes antitumor immunity in prostate cancer.

TLR3 TRPM8

6.94e-053168238316991
Pubmed

Alpha11 beta1 integrin-dependent regulation of periodontal ligament function in the erupting mouse incisor.

ITGA11 TH

6.94e-053168217420280
Pubmed

DCAF7/WDR68 is required for normal levels of DYRK1A and DYRK1B.

DYRK1A DYRK1B

6.94e-053168230496304
Pubmed

Essential role of mda-5 in type I IFN responses to polyriboinosinic:polyribocytidylic acid and encephalomyocarditis picornavirus.

TICAM1 TLR3

6.94e-053168216714379
Pubmed

Double-stranded RNA upregulates the expression of inflammatory mediators in human aortic valve cells through the TLR3-TRIF-noncanonical NF-κB pathway.

TICAM1 TLR3

6.94e-053168228052863
Pubmed

ZCCHC3 modulates TLR3-mediated signaling by promoting recruitment of TRIF to TLR3.

TICAM1 TLR3

6.94e-053168232133501
Pubmed

Dengue virus downregulates TNFR1- and TLR3-stimulated NF-κB activation by targeting RIPK1.

TLR3 TNFRSF1A

6.94e-053168236310878
Pubmed

Toll-like receptor 3 mediates West Nile virus entry into the brain causing lethal encephalitis.

TLR3 TNFRSF1A

6.94e-053168215558055
Pubmed

The effects of TLR3, TRIF and TRAF3 SNPs and interactions with environmental factors on type 2 diabetes mellitus and vascular complications in a Han Chinese population.

TICAM1 TLR3

6.94e-053168228479387
Pubmed

TRIM38 negatively regulates TLR3-mediated IFN-β signaling by targeting TRIF for degradation.

TICAM1 TLR3

6.94e-053168223056470
Pubmed

DYRK1A binds to an evolutionarily conserved WD40-repeat protein WDR68 and induces its nuclear translocation.

DYRK1A DYRK1B

6.94e-053168221777625
Pubmed

Mumps Virus SH Protein Inhibits NF-κB Activation by Interacting with Tumor Necrosis Factor Receptor 1, Interleukin-1 Receptor 1, and Toll-Like Receptor 3 Complexes.

TLR3 TNFRSF1A

6.94e-053168228659487
Pubmed

Ancestry and frequency of genetic variants in the general population are confounders in the characterization of germline variants linked to cancer.

BTNL8 BTNL3

6.94e-053168232375678
Pubmed

TLR3, TRIF, and caspase 8 determine double-stranded RNA-induced epithelial cell death and survival in vivo.

TICAM1 TLR3

6.94e-053168223209324
Pubmed

TRIM56 Suppresses Multiple Myeloma Progression by Activating TLR3/TRIF Signaling.

TICAM1 TLR3

6.94e-053168229214775
Pubmed

TIR-domain-containing adapter-inducing interferon-β contributes to TLR3/TLR4 triggered apoptosis and inflammation in nucleus pulposus cells.

TICAM1 TLR3

6.94e-053168232529819
Pubmed

The human cytoplasmic dynein interactome reveals novel activators of motility.

SHROOM3 PKD1L1 DYRK1A CEP192 KLHL22 KIAA1671 AP4E1 FAM120A EIF4ENIF1 SYNJ1 PLEC HERC2 PCCB AGRN

7.39e-058531681428718761
Pubmed

Interactomes of Glycogen Synthase Kinase-3 Isoforms.

CEP192 PRUNE1 KIAA1671 VPS13D FAM120A EIF4ENIF1 MACF1

7.47e-05209168736779422
Pubmed

Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.

SHROOM3 PDCD6IP EPB41L4B MUC16 CEP192 FAM171B KIAA1671 AP4E1 EEF2 ADAMTS16 PCCB GCN1 IQCE

1.11e-047771681335844135
Pubmed

A human MAP kinase interactome.

KPNA4 PDCD6IP FOS KMT2C DYRK1B MACF1 PLEC HERC2 GCN1 WNK2

1.36e-044861681020936779
Pubmed

TNF-alpha inhibits macrophage clearance of apoptotic cells via cytosolic phospholipase A2 and oxidant-dependent mechanisms.

PLA2G4A TNFRSF1A

1.38e-044168217548650
Pubmed

Trif is not required for immune complex glomerulonephritis: dying cells activate mesangial cells via Tlr2/Myd88 rather than Tlr3/Trif.

TICAM1 TLR3

1.38e-044168219158348
Pubmed

A critical link between Toll-like receptor 3 and type II interferon signaling pathways in antiviral innate immunity.

TICAM1 TLR3

1.38e-044168219074283
Pubmed

Tumor necrosis factor-alpha (TNF-alpha) regulates shedding of TNF-alpha receptor 1 by the metalloprotease-disintegrin ADAM8: evidence for a protease-regulated feedback loop in neuroprotection.

VPS54 TNFRSF1A

1.38e-044168220826683
Pubmed

Extracellular MicroRNAs Induce Potent Innate Immune Responses via TLR7/MyD88-Dependent Mechanisms.

TICAM1 TLR3

1.38e-044168228768728
Pubmed

Cytomegalovirus M45 cell death suppression requires receptor-interacting protein (RIP) homotypic interaction motif (RHIM)-dependent interaction with RIP1.

TICAM1 TLR3

1.38e-044168218442983
Pubmed

Upregulation of costimulatory molecules induced by lipopolysaccharide and double-stranded RNA occurs by Trif-dependent and Trif-independent pathways.

TICAM1 TLR3

1.38e-044168214625548
Pubmed

Polyinosinic acid is a ligand for toll-like receptor 3.

TICAM1 TLR3

1.38e-044168217573354
InteractionTOP3B interactions

SETD1A SCO2 SHROOM3 PDCD6IP SZT2 SREBF1 HIP1R DYRK1A NBL1 SPATA20 CARD10 CEP192 RYR1 KMT2C MDN1 FAM120A EIF4ENIF1 MROH1 SYNJ1 INF2 FAM120C NBEAL2 SCN5A PLEC HERC2 GCN1 AGRN WNK2 IQCE SYMPK

2.86e-06147016530int:TOP3B
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ urethra_emap-30902_k-means-cluster#3_top-relative-expression-ranked_1000

RELCH ATRX FAM210A TRIM35 DYRK1A FAM171B GATAD2B USP31 LNPEP MYOCD HERC2 GCN1 AGRN SMAD5

1.12e-0636916414DevelopingLowerUrinaryTract_e14.5_ urethra_emap-30902_k3_1000
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ urogenital sinus_emap-6689_k-means-cluster#2_top-relative-expression-ranked_1000

RELCH PDCD6IP ATRX FAM210A TRIM35 DYRK1A FAM171B USP31 LNPEP MYOCD HERC2 AGRN SMAD5

1.82e-0633016413DevelopingLowerUrinaryTract_e14.5_ urogenital sinus_emap-6689_k2_1000
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ urethra_emap-30902_k-means-cluster#5_top-relative-expression-ranked_500

RELCH TRIM35 GATAD2B USP31 LNPEP MYOCD HERC2 GCN1 AGRN SMAD5

2.79e-0619416410DevelopingLowerUrinaryTract_e14.5_ urethra_emap-30902_k5_500
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ urogenital sinus_emap-5517_k-means-cluster#2_top-relative-expression-ranked_500

RELCH PDCD6IP TRIM35 DYRK1A GATAD2B USP31 LNPEP KIF2A GCN1 AGRN

5.41e-0620916410gudmap_developingLowerUrinaryTract_e14.5_ urogenital sinus_500_k2
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ urogenital sinus_emap-5517_k-means-cluster#4_top-relative-expression-ranked_1000

RELCH PDCD6IP TRIM35 DYRK1A GATAD2B USP31 LNPEP MYOCD KIF2A HERC2 GCN1 AGRN SMAD5

9.70e-0638516413gudmap_developingLowerUrinaryTract_e14.5_ urogenital sinus_1000_k4
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ urethra_emap-30892_k-means-cluster#5_top-relative-expression-ranked_500

RELCH TRIM35 GATAD2B USP31 LNPEP MYOCD AGRN SMAD5

2.11e-051491648gudmap_developingLowerUrinaryTract_e14.5_ urethra_500_k5
ToppCellPBMC-Mild-cDC_4|Mild / Compartment, Disease Groups and Clusters

FAM171B PLEKHH1 TTC23 FAM120C AJM1 CCDC24 GPSM1

7.19e-071331677e53fbd69775a4bff61de82557342f7ac80915c4d
ToppCellCOVID-19-Heart-CM_+_Macrophage|COVID-19 / Disease (COVID-19 only), tissue and cell type

XIRP1 GREB1L SCN5A MYOCD CFAP61 ALPK2 WNK2

3.70e-0617016773f15242a1d3e4e9871d9170b2ef05842fb609c29
ToppCellCOVID-19-Heart-CM_1|COVID-19 / Disease (COVID-19 only), tissue and cell type

GAS2 GREB1L SCN5A MYOCD CFAP61 ALPK2 WNK2

6.23e-061841677e737f0f14c49b07bbb04a165083ac32210bc5690
ToppCellCOVID-19-Heart-CM_2|COVID-19 / Disease (COVID-19 only), tissue and cell type

XIRP1 GREB1L SCN5A MYOCD CFAP61 ALPK2 WNK2

6.45e-061851677549eeb521c3985bff396ea0f202db21822efa51f
ToppCellRV-04._Ventricular_Cardiomyocyte_I|RV / Chamber and Cluster_Paper

GAS2 GREB1L SCN5A MYOCD CFAP61 ALPK2 WNK2

7.42e-0618916779c1debd65c13d63fd4f3158917d621b44b714c26
ToppCellCOVID-19-Heart-CM_1|Heart / Disease (COVID-19 only), tissue and cell type

GAS2 GREB1L SCN5A MYOCD CFAP61 ALPK2 WNK2

9.09e-061951677f1ef50331eda8f1239dba6ea970df4eaccf032f1
ToppCelldroplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ATRX KDM5D KMT2C FAM120A KCNB1 SYNJ1 MACF1

9.09e-0619516773e519cffa6144a62b06124642a14c9ff39b76554
ToppCellMS-CD8-exh_CD4|MS / Condition, Cell_class and T cell subcluster

UPB1 GTDC1 KCNB1 TRIM32 TLR3 SYMPK

1.61e-0514216767591491520a883bb09fa2b8d0a20ae2abd2b8703
ToppCellPBMC-Mild-Myeloid-cDC-cDC-cDC_4|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

FAM171B PLEKHH1 TTC23 FAM120C CCDC24 GPSM1

2.46e-05153167691e9d70a5d3f6fd68c284ed0cc113f03d7d1e10b
ToppCellPBMC-Mild-Myeloid-cDC-cDC-cDC_4|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

FAM171B PLEKHH1 TTC23 FAM120C CCDC24 GPSM1

2.46e-051531676f17f62646633cf95c810dcd5328978058741b276
ToppCellControl-PLT_4|World / Disease Group and Platelet Clusters

KPNA4 SAXO2 EFHC2 EIF4ENIF1 TTC23 DENND2C

2.55e-051541676a2a03c5e6759c45aeeedf1e68ecb5a0112ef9a20
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

SHROOM3 BLNK FSTL4 ZSCAN5B ADAMTS16 TRPM8

2.84e-0515716762c5295043611bac7dfa4aef2146681bce4a33a8f
ToppCellTCGA-Stomach-Primary_Tumor-Stomach_Adenocarcinoma-Stomach_Adenocarcinoma_-_Tubular-6|TCGA-Stomach / Sample_Type by Project: Shred V9

SHROOM3 FAM120A INF2 PLA2G4A GCN1 IQCE

3.05e-051591676655c0749c238bd68cb797adb83e25a23b8a3cc9d
ToppCellfacs-Trachea-18m-Epithelial-glandular_epithelial-lung_secretory_cell|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

EPB41L4B FSTL4 GREB1L KCNJ16 CFAP61 ALPK2

3.63e-051641676cdb8cd2d6b369189ea77e4946738e2816d502e03
ToppCellfacs-Trachea-18m-Epithelial-glandular_epithelial|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

EPB41L4B FSTL4 GREB1L KCNJ16 CFAP61 ALPK2

3.63e-0516416765dbfcdd450f652b16d97da53b528d4584b0eabcf
ToppCellfacs-Trachea-18m-Epithelial-glandular_epithelial-lung_secretory_cell-mucous|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

EPB41L4B FSTL4 GREB1L KCNJ16 CFAP61 ALPK2

3.63e-051641676f1423f4434af4af9c60c8a5b0b0abec4a7df9401
ToppCellCOVID-19-kidney-PEC|COVID-19 / Disease (COVID-19 only), tissue and cell type

CFH PDZK1 TMEM130 KCNJ16 ADAMTS16 ALPK2

4.15e-051681676a086c306be430adf0632ba53e98cd8014d2de330
ToppCell5'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.2|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

TTC21A SAXO2 SNED1 CFAP61 TMEM231 CCDC191

4.29e-051691676fba841664939c771881ba97f14ef1df6635c04ff
ToppCell343B-Lymphocytic-NK_cells-NK_cell_D3|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

FOS NBL1 SOX13 TMEM130 NOCT AGRN

5.05e-051741676e5f12831187140e84b9a49e93b2376b9fefb1aec
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PDZK1 EML6 GREB1L PLEKHH1 CFAP61 ALPK2

5.21e-051751676284fdc7a9d303636a637041846850d19d114861a
ToppCell343B-Lymphocytic-NK_cells-NK_cell_D3|NK_cells / Donor, Lineage, Cell class and subclass (all cells)

FOS NBL1 SOX13 TMEM130 NOCT AGRN

5.38e-051761676bd5c85b3a4fb88ffe156599f6d224aa7664a513a
ToppCellFetal_29-31_weeks-Epithelial-ciliated_cell-D062|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

SAXO2 PTPRT C1orf141 EFHC2 KCNJ16 CFAP61

5.73e-051781676de5d50d7ca9ee9eb62f50c88a0c6d47f0694b2e6
ToppCellCOVID-19-Heart-CM_+_EC_+_Pericyte|COVID-19 / Disease (COVID-19 only), tissue and cell type

XIRP1 GREB1L SCN5A MYOCD CFAP61 ALPK2

6.28e-051811676719eb532453ab7cd7893726885bc75d74a10b21e
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

DOCK8 PDZK1 GREB1L ADAMTS16 GLIS1 ALPK2

6.48e-0518216765e1b316599436740f1b30875f0ebd33c3edfb2b6
ToppCellAdult-Mesenchymal-matrix_fibroblast_2_cell-D231|Adult / Lineage, Cell type, age group and donor

CFH MASP1 ITGA11 NBL1 SNED1 KCNJ16

7.09e-051851676fb6bd7e849ecf4ed9cd9c4e2a946a2d12d62f804
ToppCellCOVID-19-Epithelial_cells-Airway_ciliated|COVID-19 / group, cell type (main and fine annotations)

MUC16 SAXO2 PTPRT EFHC2 CFAP61 TMEM231

7.09e-05185167618a40f0a338aa398d81384b5159fb80ce8a2020c
ToppCellfacs-Heart-LA-24m-Mesenchymal-ventricular_cardiomyocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

XIRP1 ASB10 SCN5A MYOCD ALPK2 WNK2

7.30e-051861676337f768cc43db2db96ba6495b076006b1a5b0331
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

DOCK8 PDZK1 EML6 GREB1L ADAMTS16 ALPK2

7.30e-0518616765c4ffe4e4d5536ae9f8794277fe032c693e7dd56
ToppCellfacs-Heart-LA-24m-Mesenchymal-ventricular_myocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

XIRP1 ASB10 SCN5A MYOCD ALPK2 WNK2

7.30e-051861676e378c82ef6d6cb24751515aa499a01372b3e7ccf
ToppCellCiliated_cells-B-SSc-ILD_01|World / lung cells shred on cell class, cell subclass, sample id

SAXO2 PTPRT C1orf141 EFHC2 KCNJ16 TMEM231

7.52e-0518716762b4262c2e7c7830a976be168cee6eeb738d4feda
ToppCellfacs-Heart-Unknown-3m-Mesenchymal|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

XIRP1 ASB10 SCN5A MYOCD ALPK2 WNK2

7.52e-0518716760ffb988e0da2c7205c3515eca8e9851739bff5c5
ToppCellCOVID-19-kidney-Stressed_PCT|kidney / Disease (COVID-19 only), tissue and cell type

UPB1 PDZK1 SLC5A11 NOCT GLIS1 ALPK2

7.52e-051871676acd305475f3609800af0d7bc68d83ef41228080b
ToppCellRV-04._Ventricular_Cardiomyocyte_I|World / Chamber and Cluster_Paper

GAS2 SCN5A MYOCD CFAP61 ALPK2 WNK2

7.52e-05187167678cdcf8bc141d3b155c3c8af908431fc419c4d08
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Outer_Medullary_Collecting_Duct_Principal_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

EML6 BLNK FSTL4 HIP1R GREB1L SSH2

7.52e-051871676e3095455d2f255854f339f6b05fa87852af0700f
ToppCellCOVID-19-kidney-DCT|kidney / Disease (COVID-19 only), tissue and cell type

SHROOM3 SALL3 BLNK FSTL4 KCNJ16 ADAMTS16

7.75e-051881676df1fd0819d301679f3c9ea404e942e39095912eb
ToppCellcellseq2-Endothelial-Endothelial_Vascular-Endothelial_large_blood_vessel-VEC|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

CARD10 GTDC1 CHN1 MAP3K12 TTC23 TMEM39A

7.98e-051891676bccb3481ffed597c845fe860da658505316105b5
ToppCellfacs-Heart-RA-24m-Mesenchymal-ventricular_myocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

XIRP1 ASB10 SCN5A MYOCD ALPK2 WNK2

7.98e-051891676e758b264c0a47127e33e66c395cf5a3224c7305b
ToppCellfacs-Heart-RA-24m-Mesenchymal-ventricular_cardiomyocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

XIRP1 ASB10 SCN5A MYOCD ALPK2 WNK2

7.98e-051891676b98f60875b1a12b2ec9dc91889298ae57f98602f
ToppCellRV-06._Ventricular_Cardiomyocyte_II|RV / Chamber and Cluster_Paper

GAS2 SCN5A MYOCD GPSM1 ALPK2 WNK2

8.21e-051901676fe8e78922c8ae928ef9a80bffd67868d5a87a091
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Inner_Medullary_Collecting_Duct_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SHROOM3 BLNK HIP1R GREB1L NBEAL2 KCNJ16

8.45e-0519116763e828cffa24ded19f591a7ed6c1fe88ad57fdcac
ToppCellnucseq-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Ciliated|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

MUC16 SAXO2 PTPRT EFHC2 CFAP61 TMEM231

8.45e-051911676e417bf491f8b8d7838a61f7f4f6b1740ba97aa3f
ToppCellnucseq-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

MUC16 SAXO2 PTPRT EFHC2 CFAP61 TMEM231

8.45e-0519116769d31c8424d35bdc0c27188b68bfd0f731af3600b
ToppCell15-Trachea-Epithelial-Intermediate_ciliated|Trachea / Age, Tissue, Lineage and Cell class

EPB41L4B TTC21A MUC16 SAXO2 KIAA1671 TMEM231

8.70e-0519216769cbe961a800c981cdc742a47ed18e9c8eb6430bd
ToppCellfacs-Brain_Myeloid-Hippocampus-3m-Myeloid|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CFH DOCK8 FOS TLR3 MACF1 SSH2

8.95e-05193167606b65110db974f4ef90d3511ff34428976a52c9c
ToppCellfacs-Brain_Myeloid-Hippocampus-3m-Myeloid-microglial_cell|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CFH DOCK8 FOS TLR3 MACF1 SSH2

8.95e-0519316769c16032bc03df8760ae199e8f19fdafa4c3f1827
ToppCellfacs-Brain_Myeloid-Hippocampus-3m|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CFH DOCK8 FOS TLR3 MACF1 SSH2

8.95e-051931676a4f91bca5eaa985982d33a528f7566ffde154d47
ToppCellfacs-Brain_Myeloid-Hippocampus-3m-Myeloid-nan|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CFH DOCK8 FOS TLR3 MACF1 SSH2

8.95e-051931676b39d7feaac4ff8f7409cd3d15e8f3c6391367275
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SHROOM3 BLNK HIP1R GREB1L NBEAL2 KCNJ16

9.21e-05194167604bfc555743f7d8821439d05ae442d15e9886c59
ToppCell343B-Endothelial_cells-Endothelial-B_(Artery)|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)

CFH FOS HIP1R PPP2R2A OTC PLA2G4A

9.21e-051941676582db7f7fa9aa08027ae18ed607945b5d1dc908a
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SHROOM3 BLNK HIP1R GREB1L NBEAL2 KCNJ16

9.21e-05194167669bff17df4a760ccf081cf52ff04af02c14f448d
ToppCell3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.3.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

TTC21A MUC16 SAXO2 C1orf141 TMEM231 CCDC191

9.21e-0519416764a2c127c90d1fefe604fcb9e796577d21b489dd6
ToppCell343B-Endothelial_cells-Endothelial-B_(Artery)-|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)

CFH FOS HIP1R PPP2R2A OTC PLA2G4A

9.21e-051941676bda89111386398a072b70e8153b2a762298a047a
ToppCellSmart-seq2-spleen_(Smart-seq2)-myeloid-myeloid_granulocytic-neutrophil|spleen_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

SHROOM3 EPB41L4B MUC16 PTPRT KCNB1 OTOGL

9.47e-051951676d3755929ebbbf5e3afde44281e9056ddb614a291
ToppCellSmart-seq2-spleen_(Smart-seq2)-myeloid-myeloid_granulocytic|spleen_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

SHROOM3 EPB41L4B MUC16 PTPRT KCNB1 OTOGL

9.47e-05195167619853c654ac64b3ae3bc99841c6cb29c8aaba85c
ToppCellCOVID-19-Heart-CM_2|Heart / Disease (COVID-19 only), tissue and cell type

GREB1L SCN5A MYOCD CFAP61 ALPK2 WNK2

9.47e-05195167675fc81bddb246dca3b437fb60827b1d4fe416405
ToppCelldroplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ATRX KDM5D KMT2C FAM120A KCNB1 MACF1

9.47e-0519516767796ea9247f4c63762f0de8490fed08b9717fa23
ToppCellprimary_visual_cortex-Neuronal-glutamatergic_neuron-L5_IT-L5_IT_VISp_Col6a1_Fezf2|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

MASP1 MROH5 BLNK PTPRT INF2

9.69e-051221675e96aec5af0ed1d8f4cc99fde59dd6998bbc1acbd
ToppCell(01)_IL1RL1+-(1)_GFP|(01)_IL1RL1+ / shred by cell type by condition

FOS TTC21A NBL1 EEF2 PLEC TNFRSF1A

9.74e-051961676b598b1112242534e139318012b257ed3cb09da83
ToppCelldroplet-Tongue-TONGUE-1m-Epithelial-basal_cell_of_epidermis|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ATRX TRIM35 NBL1 EEF2 TRIM32 AGRN

9.74e-051961676d4df86ce289835e76763213641989fde77935a16
ToppCell3'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

TTC21A SAXO2 PTPRT KCNB1 TMEM231 CCDC191

1.00e-04197167674a2c6cb8fcfe53dd9a2b36492a16c58f38e51c9
ToppCelldistal-3-Epithelial-Proximal_Ciliated|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

EPB41L4B MUC16 SAXO2 PTPRT EFHC2 TMEM231

1.00e-04197167615b4d1203943ce90a7083178d4a4284d9b323071
ToppCell(11)_FOXN4+-(2)_GFP_FOXI1|(11)_FOXN4+ / shred by cell type by condition

SHROOM3 ATRX MRPL45 VPS13D KIF2A SMAD5

1.03e-04198167676d40b8c2f8399725b3a62ee2ae0896559cf91eb
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

SHROOM3 HIP1R KCNJ16 ADAMTS16 MACF1 AGRN

1.06e-0419916763cd6383c50ce342fe5c175e2e50784d634a90e80
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW12-Mesenchymal-Unfolded_protein_responsible_cell|GW12 / Sample Type, Dataset, Time_group, and Cell type.

TTC21A NAA80 F12 TMEM231 CCDC24 PHTF1

1.09e-0420016766b7314c425f6b40f1301dd39cc02b0436e96a2ec
ToppCellMacroglial-Astrocytes-GFAP---|Macroglial / cells hierarchy compared to all cells using T-Statistic

MASP1 SHROOM3 FOS SNED1 PLEC WNK2

1.09e-04200167688d66550781a3c9102ff7455f5cff6fb072943cd
ToppCellMacroglial-Astrocytes-GFAP-|Macroglial / cells hierarchy compared to all cells using T-Statistic

MASP1 SHROOM3 FOS SNED1 PLEC WNK2

1.09e-042001676d6a059b0ef763c281c60b1ac76da6079ea822f80
ToppCellMacroglial-Astrocytes-GFAP--|Macroglial / cells hierarchy compared to all cells using T-Statistic

MASP1 SHROOM3 FOS SNED1 PLEC WNK2

1.09e-04200167616269fa4adb28fc6ed032bbdba8781237dd0d249
ToppCellMacroglial-Astrocytes-GFAP----L1-2|Macroglial / cells hierarchy compared to all cells using T-Statistic

MASP1 SHROOM3 FOS SNED1 PLEC WNK2

1.09e-042001676c6f43bbbd5df5f2c19ae385f1a6b6a330abede2f
ToppCellLung_Parenchyma-Control-Epithelial-Epithelial-Ciliated|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

TTC21A SAXO2 PTPRT C1orf141 EFHC2 TMEM231

1.09e-042001676ddd39b754bfaa98249d497dfb7e97ec58617a11a
ToppCellParenchyma_Control_(B.)-Epithelial-TX-Ciliated|Parenchyma_Control_(B.) / Sample group, Lineage and Cell type

TTC21A SAXO2 PTPRT C1orf141 EFHC2 TMEM231

1.09e-042001676a521cf837cadf280505ff9d7e641a205af7d6513
ToppCellLung_Parenchyma-Control-Epithelial-Epithelial-Ciliated-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

TTC21A SAXO2 PTPRT C1orf141 EFHC2 TMEM231

1.09e-042001676918b576fd9491d23c2bb9d663fa5fb3505cb1c7e
ToppCellMacroglial-Astrocytes-GFAP|Macroglial / cells hierarchy compared to all cells using T-Statistic

MASP1 SHROOM3 FOS SNED1 PLEC WNK2

1.09e-04200167679634b1086934412ae92f259ab43554ce545008f
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Meis2|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

SALL3 CARD10 TH GPSM1

1.24e-046816743c5d0d35e4d1c5506a4a490e2f93e8024294207f
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Meis2-Meis2_Adamts19|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

SALL3 CARD10 TH GPSM1

1.24e-046816743a61ea2b234829632fabede72761aa6664550e56
ToppCelldroplet-Lung-immune-endo-depleted-3m-Myeloid-neutrophil|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RASGRP4 GTDC1 MDN1 PLA2G4A GPSM1

1.45e-041331675f6e9a1301a3379847b215303a9b0c028841e2cc0
ToppCelldroplet-Lung-immune-endo-depleted-3m-Myeloid-Neutrophil|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RASGRP4 GTDC1 MDN1 PLA2G4A GPSM1

1.45e-041331675292ecfcadbaf15e0d34a3ab9bf511ab1065888bd
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_2|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

SALL3 FSTL4 KCNJ16 ADAMTS16 ZNF488

1.67e-04137167585b3a98039c1f68addad0334aa5b2584f6045aaa
Diseaseintellectual disability (implicated_via_orthology)

ATRX RBL2 DYRK1A KDM5D GATAD2B DYRK1B

3.55e-06751616DOID:1059 (implicated_via_orthology)
DiseaseCharcot-Marie-Tooth disease dominant intermediate E (implicated_via_orthology)

INF2 FHDC1

2.96e-0521612DOID:0110205 (implicated_via_orthology)
Diseasegrowth/differentiation factor 8 measurement

PMS1 CFH

2.96e-0521612EFO_0021960
DiseaseDown syndrome (implicated_via_orthology)

DYRK1A SYNJ1 DYRK1B

6.91e-05151613DOID:14250 (implicated_via_orthology)
Diseasesyndromic intellectual disability (implicated_via_orthology)

DYRK1A KDM5D DYRK1B

8.47e-05161613DOID:0050888 (implicated_via_orthology)
Diseasecellular retinoic acid-binding protein 2 measurement

CFH ISG20L2

8.84e-0531612EFO_0802386
Diseasesialoadhesin measurement

CFH SIGLEC1

8.84e-0531612EFO_0020740
Diseasefood allergy measurement, parental genotype effect measurement

EML6 PROZ IQCE

1.22e-04181613EFO_0005939, EFO_0007016
Diseaseinterleukin-9 measurement

CFH SMAD5

1.76e-0441612EFO_0802663
DiseaseHerpetic Acute Necrotizing Encephalitis

TICAM1 TLR3

2.93e-0451612C0001338
Diseasematrix extracellular phosphoglycoprotein measurement

CFH F12

2.93e-0451612EFO_0020557
Diseasemyeloperoxidase measurement

CFH SMG8 NUP133

3.78e-04261613EFO_0005243
DiseaseCD63 antigen measurement

CFH F12

4.37e-0461612EFO_0022033
Diseaseserine/threonine-protein kinase ULK3 measurement

CFH F12

4.37e-0461612EFO_0803065
Diseaseoligoasthenoteratozoospermia (implicated_via_orthology)

SPATA20 CFAP61

4.37e-0461612DOID:0070311 (implicated_via_orthology)
DiseaseHerpetic meningoencephalitis

TICAM1 TLR3

4.37e-0461612C0019385
Diseaseprogonadoliberin-1 measurement

CFH F12

4.37e-0461612EFO_0801924
Diseaseinterleukin-23 receptor measurement

CFH C1orf141

4.37e-0461612EFO_0801725
Diseaseglucosidase 2 subunit beta measurement

CFH F12

4.37e-0461612EFO_0801628
Diseasecadherin-15 measurement

CFH F12

6.10e-0471612EFO_0020211
DiseaseHerpes encephalitis

TICAM1 TLR3

6.10e-0471612C0276226
Diseaseglutathione s-transferase p measurement

CFH NDUFV1

6.10e-0471612EFO_0020410
Diseaseprimary dental caries

CFH PDCD6IP FSTL4

8.43e-04341613EFO_0600095
DiseaseAsthma, Occupational

PLA2G4A HERC2

1.29e-03101612C0264423
Diseasebone morphogenetic protein 7 measurement

CFH F12

1.29e-03101612EFO_0020187
Diseasetransmembrane glycoprotein NMB measurement

CFH F12

1.29e-03101612EFO_0008303
DiseaseKunitz-type protease inhibitor 2 measurement

RASGRP4 RYR1

1.29e-03101612EFO_0008200
DiseaseDNA repair protein RAD51 homolog 4 measurement

CFH ZNF394

1.58e-03111612EFO_0801531
Diseaseosteoarthritis, knee

VPS72 BTNL8 FAM53A PLA2G4A PLEC

1.79e-031581615EFO_0004616
Diseaseevent free survival time, type 1 diabetes mellitus, autoantibody measurement

TH PHTF1

1.88e-03121612EFO_0000482, EFO_0004866, MONDO_0005147
DiseaseNeuroblastoma

ATRX DOCK8 TH

2.17e-03471613C0027819
Diseasecolon carcinoma (is_marker_for)

TLR3 TNFRSF1A

2.22e-03131612DOID:1520 (is_marker_for)
Diseasetransmembrane protein 87B measurement

CFH F12

2.22e-03131612EFO_0802158
DiseaseAdenoid Cystic Carcinoma

ATRX PDZK1 GAS2 KMT2C

2.23e-031001614C0010606
DiseaseMalignant neoplasm of breast

XIRP1 VPS72 FAM210A FOS TICAM1 PDZK1 EEF2 ZNF532 OTOGL NUP133 PLA2G4A MACF1 TMEM39A HERC2

2.34e-03107416114C0006142
DiseaseAutosomal recessive limb-girdle muscular dystrophy

TRIM32 PLEC

2.58e-03141612cv:C2931907
Diseasephoneme awareness

DYRK1A KCNB1

2.58e-03141612EFO_0021812
Diseasehepcidin:transferrin saturation ratio

EML6 MUC16

2.97e-03151612EFO_0007902
Diseasemannan-binding lectin serine protease 1 measurement

CFH MASP1

2.97e-03151612EFO_0008223
DiseaseSitus ambiguus

SHROOM3 PKD1L1

2.97e-03151612C0266642
Diseasecortical thickness

SHROOM3 VPS72 SREBF1 NBL1 GATAD2B PPP2R2A VPS13D PMPCA TPX2 MACF1 SSH2 PLEC PCCB WNK2

3.23e-03111316114EFO_0004840
Diseaselung small cell carcinoma (is_marker_for)

ATRX EEF2

3.38e-03161612DOID:5409 (is_marker_for)
Diseasedual specificity mitogen-activated protein kinase kinase 2 measurement

CFH PROZ

3.38e-03161612EFO_0008112
Diseasebasal cell carcinoma

VPS72 TICAM1 PMPCA HERC2 PHTF1

3.87e-031891615EFO_0004193
Diseasekeratinocyte carcinoma

VPS72 TICAM1 HERC2 PHTF1

4.05e-031181614EFO_0010176
Diseaselung disease severity measurement

CGGBP1 KIAA1671 AP4E1 GLIS1

4.05e-031181614EFO_0007744
Diseasesusceptibility to hepatitis B infection measurement

UPB1 EML6 PTPRT

5.21e-03641613EFO_0008405
Diseasecolorectal adenoma (is_marker_for)

FOS TNFRSF1A

5.27e-03201612DOID:0050860 (is_marker_for)
Diseaseresponse to ziprasidone

SOX13 NOCT

5.27e-03201612GO_0097337

Protein segments in the cluster

PeptideGeneStartEntry
AQCVAKERRPLDAHP

FAM210A

61

Q96ND0
TLDPETAHPKLCVSD

BTNL3

291

Q6UXE8
PERADPHALCVKAQE

CARD10

716

Q9BWT7
DKNFCVISLPHLTPE

CFAP61

416

Q8NHU2
EPVVCHPDLEERLQA

ASPSCR1

321

Q9BZE9
SLLPLCFEDELKNPH

C1orf141

171

Q5JVX7
CSLFPDHPLLQEREK

PGLS

156

O95336
LCDRHSKLFEEPEDP

PPP2R2A

261

P63151
TLDPETAHPKLCVSD

BTNL8

291

Q6UX41
TLHLCSAKESAEPPL

ALPK2

561

Q86TB3
PLDDRHPLCARLVEK

ASB10

16

Q8WXI3
HLLEDAVTKPELRPC

AGRN

2051

O00468
APHVRCRLDIKPDDA

AJM1

181

C9J069
CLEANIPLEKADHPA

CGGBP1

111

Q9UFW8
ERECELPKIDVHLVP

CFH

566

P08603
DLHLATSDPEKSCQP

DNHD1

2456

Q96M86
LATPELSIIHCDLKP

DYRK1A

276

Q13627
IDSEDSIEPPHKRLC

DMTF1

41

Q9Y222
SIEPPHKRLCLSSED

DMTF1

46

Q9Y222
PELSIIHCDLKPENI

DYRK1B

231

Q9Y463
SHLPKPSLELERACA

ADAMTS16

1096

Q8TE57
CLDHPDPIIKRETLE

AP4E1

381

Q9UPM8
LLDRDTLTKPHPCVL

CPNE6

31

O95741
PDCLTDTFRVKRPHL

IQCE

111

Q6IPM2
PDTTEEVDHKPKLCR

PDZK1

366

Q5T2W1
HQLPSELEEPALSCE

MORC1

836

Q86VD1
ESPAKRICPENHSAL

RBL2

1111

Q08999
ILCTACLHPEPKERD

RELCH

546

Q9P260
CLHPEPKERDQLLHI

RELCH

551

Q9P260
VAEVLDHRPIEPKHC

PRUNE1

121

Q86TP1
TICEVLERSHSPPLK

PRUNE1

311

Q86TP1
PTIACLEPAEVRHQD

FHDC1

581

Q9C0D6
AVDAICTHRPDPEDL

MUC16

12141

Q8WXI7
CTHRLDPKSPGVDRE

MUC16

12616

Q8WXI7
CTHRLDPKSPGVDRE

MUC16

12771

Q8WXI7
LSVCKELQLPPSDFH

NUP133

136

Q8WUM0
SELETILHKRCSLPP

MDN1

1226

Q9NU22
LCPEHIDQAPERSKE

KMT2C

326

Q8NEZ4
TLDVHCLPQLPEKAS

KMT2C

4286

Q8NEZ4
DRDCLVKAEAPLHDP

KIAA1671

326

Q9BY89
CLEKPLLPEAHSLIR

GEMIN2

221

O14893
ILAAHRPACKIPDDL

FOS

196

P01100
TLEPVHRRPELLDAC

NAA80

61

Q93015
HLPPDVRETLCKASE

GPSM1

176

Q86YR5
EACILPHSPINVDKR

HERC2

1581

O95714
FCLEARQKHPPATLE

KDM5D

976

Q9BY66
EDSLRNCIDLKPTPH

EFHC2

401

Q5JST6
VKPTHSRPEGDCREV

FAM90A14

226

P0C7W9
HRDTIVLLCKPEPEL

PDCD6IP

516

Q8WUM4
LHCLPRKPEEVDDEV

OTC

301

P00480
KDLVSLHEAQPDRLP

RASGRP4

356

Q8TDF6
RDTSHIPPLNRKADC

ISG20L2

281

Q9H9L3
SPCLSEELLDPELHV

MACF1

291

O94854
DVVDLAKEPCLHPLE

LNPEP

26

Q9UIQ6
VPDALNDRHPDVRKC

GCN1

1261

Q92616
CHILEEVAGLPPKRS

LMNTD2

91

Q8IXW0
SLKVRAHQLVLPPCD

FAM120A

266

Q9NZB2
HCVPDLVLDARSDLP

ITGA11

786

Q9UKX5
RKDLANLEVPHELPT

GATAD2B

51

Q8WXI9
TLECPGHEEVPRVDK

NBL1

96

P41271
SHLLPSERLEEQLPK

MROH1

251

Q8NDA8
PNLPEHILVCAVDKR

GREB1L

151

Q9C091
EEAEKSHPDLLQLPR

INF2

806

Q27J81
PADAREDHSCLQKVP

MYOCD

751

Q8IZQ8
PEDCSIGLLPRNHDK

PTPRT

1191

O14522
DNLKTRAECLLHPLP

NPIPB11

326

E5RHQ5
SCVKNELLPSHPLEL

POMP

36

Q9Y244
CHDPSDRLVPELDTI

PCCB

291

P05166
IKDPETLLPTNDIHR

KCNA10

186

Q16322
RPLTTADPIDEHRIC

KIF2A

211

O00139
TEKLPEREEICHFPK

ATRX

1016

P46100
KLDDPLHLRCTSSPD

HIP1R

641

O75146
LDDFVKVPCARHNLP

FBH1

886

Q8NFZ0
CKLENHISPDVRVLP

KCNB1

831

Q14721
AEVLQRLHDKLDPSP

KLHL22

251

Q53GT1
CEEKPIPAERHRGSS

BLNK

271

Q8WV28
SLLSSHDLDPRCVKP

DOCK8

1191

Q8NF50
SALKEREVPQHPSCL

FCF1

41

Q9Y324
ECLEKHLPLPDLQEV

UPB1

11

Q9UBR1
HPVDCEIQRHLKPTE

FSTL4

466

Q6MZW2
ERECTLLPETAHPDA

INTS14

461

Q96SY0
EAQSHLLSKPREEEP

CCDC191

601

Q8NCU4
SLKVRAHQLVLPPCD

FAM120C

341

Q9NX05
LPPDKLLNLALEHCD

DENND2C

156

Q68D51
CTPEKDLTPTHVLQL

MAP3K12

36

Q12852
CLHQSLDPEDPTLRD

MASP1

491

P48740
SVRVPEELKLPHACC

CEP192

1371

Q8TEP8
LLDVIRIKLDPCHPT

EDARADD

121

Q8WWZ3
ELLFAKPVPEHCASE

HGSNAT

391

Q68CP4
RLDIRAPLHPEKVCN

CLPB

691

Q9H078
LEEDHACIPIKKSDP

EEF2

561

P13639
AHPLLPICATVSDDK

EML6

1006

Q6ZMW3
SGEPPHKLLELCRDV

GADL1

91

Q6ZQY3
LQPETHLPEGSLKRC

GLIS1

51

Q8NBF1
EALKLLPPAHCETLR

CHN1

381

P15882
CPDRVPEATESLHTK

FAM240C

76

A0A1B0GVR7
DHRPKDLESIIRPKC

GTDC1

146

Q4AE62
RSCTKLPPVLIVHED

SALL3

71

Q9BXA9
THCPDICPDELEKLV

SCO2

131

O43819
CPLPEEIRQDLLDFH

RYR1

2021

P21817
CELPEHTPELVSEFR

EPB41L4B

216

Q9H329
KDEPCLIHNLRFPDA

PMS1

721

P54277
DCDNSADRIPHKPFI

PKD1L1

126

Q8TDX9
HFALEEPRCDLPEQE

CCDC24

116

Q8N4L8
TVCSPEDPALRHILD

FAM171B

751

Q6P995
HLEPIDPKELLEECR

NOCT

101

Q9UK39
RRIFIPCHDKVSPED

OTOGL

1746

Q3ZCN5
LPLFTCLHVKPDVSE

PLA2G4A

326

P47712
HIASSLCKLRPPIDL

MROH5

476

Q6ZUA9
DALEKHTCLFLEPPN

MROH5

511

Q6ZUA9
RSHCTVKDPESLLVP

SMG8

356

Q8ND04
AHCLQDRPAPEDLTV

F12

411

P00748
LLDDAVKRISEDPPC

GAS2

201

O43903
QALSDRPCLVVLHKP

SZT2

731

Q5T011
LPHELCTLIRNVKPE

PMPCA

461

Q10713
PGHCTLPVKEAAEER

TRIM32

131

Q13049
EPLRICPLHISVKEE

TRIM35

476

Q9UPQ4
VRCSLSDIPDHIPEE

TDRD6

1096

O60522
PPFSLIVETRHKEEC

SYNJ1

16

O43426
VIPPEKSDRSIHLAC

MRPL45

66

Q9BRJ2
EPGTCKDREILRHDP

NDUFV1

121

P49821
REHLVPCEDVLLTKP

OVCH1

976

Q7RTY7
QLLKEPHPTRLSAEE

NBEAL2

2336

Q6ZNJ1
SALEELEESRHKCPP

SCN5A

671

Q14524
CQPLEHDLLSPVEKK

SHROOM3

531

Q8TF72
CDQPDERPVLVKSIH

SLC5A11

506

Q8WWX8
CTPEKDFAEHLLIPR

PROZ

281

P22891
PVEDLQDPRCHVRSK

SETD1A

56

O15047
VDCGPPEEVKHATLR

SNED1

696

Q8TER0
PDLQSHHELKPLDIC

SMAD5

96

Q99717
EEAAERLCPLVEHLP

SREBF1

891

P36956
LDIKELPHSKQRPSC

EIF4ENIF1

36

Q9NRA8
TLLKEHEDTCAPPAE

ANHX

6

E9PGG2
LLADREDSLPKLCHA

C17orf64

156

Q86WR6
DVDKDVLLPHPLRST

TEX22

106

C9J3V5
PLDEDPSKLCRHSLK

ZNF532

741

Q9HCE3
SPAKERLEDGCVHPL

SOX13

386

Q9UN79
DPHSQKRREEALACP

ZNF488

306

Q96MN9
VLCQHIPKAERPTDS

ZNF394

296

Q53GI3
DCSHLKLTQVPDDLP

TLR3

36

O15455
REPASCESPHLKLLQ

SSH2

1276

Q76I76
ETDNDPSCVHPIIKR

PHTF1

221

Q9UMS5
RTKPVPLHCDIIGDA

THG1L

271

Q9NWX6
HLLAEEKLCPASLRD

TICAM1

101

Q8IUC6
HSCPLSPDLIRNEVE

TMEM39A

261

Q9NV64
SVPITDPCELRKLLH

SPATA20

771

Q8TB22
SCPEESDPIQALRKL

ZSCAN5B

51

A6NJL1
LHIEKAPPVRESCTS

KCNJ16

351

Q9NPI9
VDSDPPARLQLLHKD

SIGLEC1

626

Q9BZZ2
VDPSKSHRVPLDVAC

PLEC

3281

Q15149
ALETREPENPSLHLK

TTC21A

286

Q8NDW8
EDKRPLGCLPVRDAH

PLEKHH1

721

Q9ULM0
HELIPTESCKPLNIA

SAXO2

326

Q658L1
DKCPELREPLLAHVR

SYMPK

1066

Q92797
DIPLEDPDRPVHCSK

PLEKHA3

251

Q9HB20
IRVHTKSCPAPNELD

ZNF786

751

Q8N393
PVTVTPRGDLCKEHL

TMEM231

301

Q9H6L2
RLKPECLPLEEGECH

TMEM130

276

Q8N3G9
ALFQPPREKLHLCEE

TTC23

36

Q5W5X9
EQPLCHPIVERALKS

USP31

531

Q70CQ4
CRSPCLEPHILKRNE

ZC3H12C

121

Q9C0D7
PHCERPLTQEELLRE

VPS72

161

Q15906
TPPIIHRDLKCDNIF

WNK2

316

Q9Y3S1
SKPLCVELDEHNLPR

TRPM8

936

Q7Z2W7
KDICLEPPHLSIEVS

TGM7

601

Q96PF1
VPHLGDREKRDSVCP

TNFRSF1A

31

P19438
IGEHERPAAKEPVLC

XIRP1

106

Q702N8
ENEHLLDLCPEPRTE

ZNF169

76

Q14929
DHPCLQAPELDERLV

USP17L2

411

Q6R6M4
NICPPKDTFERTLLH

VPS54

136

Q9P1Q0
PLISHLEREVDPCVQ

ZNF311

111

Q5JNZ3
EFHSRPCPTKILEDV

TPX2

456

Q9ULW0
LHCLSEEPEIRAFDP

TH

431

P07101
HSPRIDCDIQLETIP

VPS13D

261

Q5THJ4
PTKRHCRSLSEPEEL

FAM53A

116

Q6NSI3
LPILVHCLERDDNPS

KPNA4

116

O00629