Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionextracellular matrix constituent, lubricant activity

MUC17 MUC3A

5.71e-064202GO:0030197
GeneOntologyMolecularFunctionextracellular matrix structural constituent

MUC17 MUC3A MUC6

8.32e-04188203GO:0005201
GeneOntologyCellularComponentGolgi lumen

MUC17 MUC16 MUC3A MUC6 MUC3B MUC12

8.91e-10109216GO:0005796
DomainSEA_dom

MUC17 MUC16 MUC3A MUC3B MUC12

3.57e-1123215IPR000082
DomainSEA

MUC17 MUC16 MUC3A MUC3B MUC12

3.57e-1123215PS50024
DomainSEA

MUC17 MUC16 MUC3A MUC3B

1.17e-0914214SM00200
DomainSEA

MUC17 MUC16 MUC3B MUC12

8.53e-0922214PF01390
Domain-

MUC17 MUC16

1.25e-04152123.30.70.960
DomainEGF_1

MUC17 MUC3A MUC3B MUC12

1.69e-04255214PS00022
DomainEGF-like_CS

MUC17 MUC3A MUC3B MUC12

1.85e-04261214IPR013032
DomainEGF_2

MUC17 MUC3A MUC3B MUC12

1.96e-04265214PS01186
DomainEGF

MUC17 MUC3A MUC3B

2.21e-03235213SM00181
DomainEGF_3

MUC17 MUC3A MUC3B

2.21e-03235213PS50026
DomainEGF-like_dom

MUC17 MUC3A MUC3B

2.61e-03249213IPR000742
PathwayREACTOME_DEFECTIVE_GALNT3_CAUSES_HFTC

MUC17 MUC16 MUC3A MUC6 MUC12

4.09e-1216165M27410
PathwayREACTOME_DEFECTIVE_C1GALT1C1_CAUSES_TNPS

MUC17 MUC16 MUC3A MUC6 MUC12

5.78e-1217165M27412
PathwayREACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS

MUC17 MUC16 MUC3A MUC6 MUC12

3.13e-1123165M556
PathwayREACTOME_DECTIN_2_FAMILY

MUC17 MUC16 MUC3A MUC6 MUC12

6.11e-1126165M27483
PathwayREACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS

MUC17 MUC16 MUC3A MUC6 MUC12

5.87e-0962165M546
PathwayREACTOME_DISEASES_ASSOCIATED_WITH_O_GLYCOSYLATION_OF_PROTEINS

MUC17 MUC16 MUC3A MUC6 MUC12

9.43e-0968165M27303
PathwayREACTOME_O_LINKED_GLYCOSYLATION

MUC17 MUC16 MUC3A MUC6 MUC12

1.13e-07111165M27416
PathwayREACTOME_C_TYPE_LECTIN_RECEPTORS_CLRS

MUC17 MUC16 MUC3A MUC6 MUC12

3.60e-07140165M27484
PathwayREACTOME_DISEASES_OF_GLYCOSYLATION

MUC17 MUC16 MUC3A MUC6 MUC12

4.00e-07143165M27275
PathwayREACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS

MUC17 MUC16 MUC6

1.58e-0621163MM15706
PathwayREACTOME_DISEASES_OF_METABOLISM

MUC17 MUC16 MUC3A MUC6 MUC12

6.27e-06250165M27554
PathwayREACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS

MUC17 MUC16 MUC6

3.95e-0560163MM15636
PathwayREACTOME_O_LINKED_GLYCOSYLATION

MUC17 MUC16 MUC6

2.34e-04109163MM15164
PathwayREACTOME_INNATE_IMMUNE_SYSTEM

MUC17 MUC16 MUC3A MUC6 DEFB129 MUC12

1.03e-031128166M1036
Pubmed

Mucin gene expression in human laryngeal epithelia: effect of laryngopharyngeal reflux.

MUC17 MUC16 MUC3A MUC6 MUC12

4.09e-131821518834073
Pubmed

Genomic organization and structure of the 3' region of human MUC3: alternative splicing predicts membrane-bound and soluble forms of the mucin.

MUC17 MUC3A MUC3B

1.90e-10321310512748
Pubmed

MUC3 human intestinal mucin. Analysis of gene structure, the carboxyl terminus, and a novel upstream repetitive region.

MUC3A MUC3B

3.47e-0722129334251
Pubmed

Initiation of transcription of the MUC3A human intestinal mucin from a TATA-less promoter and comparison with the MUC3B amino terminus.

MUC3A MUC3B

3.47e-07221212958310
Pubmed

Molecular cloning of cDNAs derived from a novel human intestinal mucin gene.

MUC3A MUC3B

3.47e-0722122393399
Pubmed

Associations of distinct variants of the intestinal mucin gene MUC3A with ulcerative colitis and Crohn's disease.

MUC3A MUC3B

3.47e-07221211289722
Pubmed

Multiple transcripts of MUC3: evidence for two genes, MUC3A and MUC3B.

MUC3A MUC3B

3.47e-07221210973822
Pubmed

The MUC3 gene encodes a transmembrane mucin and is alternatively spliced.

MUC3A MUC3B

3.47e-07221210405327
Pubmed

Expression of mucin 3 and mucin 5AC in arthritic synovial tissue.

MUC3A MUC3B

1.04e-06321218163520
Pubmed

Differential Expression of MUC12, MUC16, and MUC20 in Patients with Active and Remission Ulcerative Colitis.

MUC16 MUC12

1.04e-06321226770020
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

NAV3 TTC28 ZCCHC14 RUBCN NUP214

3.73e-0640721512693553
Pubmed

Expression of Muc19/Smgc gene products during murine sublingual gland development: cytodifferentiation and maturation of salivary mucous cells.

MUC16 MUC6

5.20e-06621219110483
Pubmed

Loss of DLG5 promotes breast cancer malignancy by inhibiting the Hippo signaling pathway.

YAP1 DLG5

1.25e-05921228169360
Pubmed

DLG5 connects cell polarity and Hippo signaling protein networks by linking PAR-1 with MST1/2.

YAP1 DLG5

3.15e-051421228087714
Pubmed

Counteractive and cooperative actions of muscle β-catenin and CaV1.1 during early neuromuscular synapse formation.

YAP1 MUSK

5.90e-051921235340430
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

TTC28 ZCCHC14 YAP1 DLG5 MUSK

1.34e-0486121536931259
Cytoband7q22

MUC3A MUC3B MUC12

6.89e-07382137q22
CytobandEnsembl 112 genes in cytogenetic band chr7q22

MUC17 MUC3A MUC12

1.34e-04219213chr7q22
GeneFamilyCD molecules|Mucins

MUC17 MUC16 MUC3A MUC6 MUC3B MUC12

8.90e-1521166648
CoexpressionNABA_ECM_AFFILIATED

MUC17 MUC16 MUC3A MUC6 MUC12

1.55e-07170205M5880
ToppCell10x5'-GI_small-bowel|World / Manually curated celltypes from each tissue

MUC17 MUC3A GPR34 MUC12

1.51e-06193204cd89dfe53a114078f06343049685883c8e26508f
ToppCellprimary_visual_cortex-Neuronal-glutamatergic_neuron-L6b-L6b_VISp_Col8a1_Rxfp1|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

YAP1 DLG5 ARHGAP25

2.65e-0513120381efe8b0ca4377e557a42ddb12aecaf3f46b15bf
ToppCellTCGA-Stomach-Primary_Tumor-Stomach_Adenocarcinoma-Stomach_Adenocarcinoma_-_Diffuse-3|TCGA-Stomach / Sample_Type by Project: Shred V9

NAV3 MUSK ARHGAP25

5.47e-05167203d2230c894ccf9dbba9196e079ae81f384d43da63
ToppCellnucseq-Epithelial-Epithelial_Glandular|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

MUC17 MUC16 MUC3A

6.72e-05179203859cd8ee414ad6207c046ada2e655e49322dd01c
ToppCellnucseq-Epithelial-Epithelial_Glandular-Goblet|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

MUC17 MUC16 MUC3A

6.83e-051802033dc80bc636bf0e6ffc9762853132a9fe59fd1f66
ToppCellnucseq-Epithelial-Epithelial_Glandular-Goblet-Goblet|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

MUC17 MUC16 MUC3A

6.83e-05180203668a2d8e1d5a390309d5eb62c836f5903144bea9
ToppCellControl-Epithelial_cells-Airway_mucous|Control / group, cell type (main and fine annotations)

MUC17 MUC16 MUC3A

7.17e-0518320315d24a4fb1ffe6cbafbd54fcd7dde9ddcfbe03b2
ToppCellControl-Epithelial_cells-Airway_goblet|Control / group, cell type (main and fine annotations)

MUC17 MUC16 MUC3A

7.29e-05184203d92a71441e4e19f8c301999d8186f8e48e3cd162
ToppCellTCGA-Pancreas-Primary_Tumor-Pancreatic_Adenocarcinoma-Ductal_Adenocarcinoma-4|TCGA-Pancreas / Sample_Type by Project: Shred V9

NAV3 TTC28 GPR34

7.29e-0518420367164bb6bcae7322cb89b585c7aa10bce35b0ecd
ToppCellCOVID-19-Fibroblasts-Other_FB|COVID-19 / group, cell type (main and fine annotations)

NAV3 TTC28 YAP1

8.40e-05193203e6b75be08e33c1de079fb5c02f0b4468128b369c
ToppCellIIH-mono3|IIH / Condition, Cell_class and T cell subcluster

NAV3 CDK2AP1 GPR34

8.66e-05195203c6dd5af582d257be64b718e30f60220c1bf1738a
ToppCellCOVID-19-Fibroblasts-Alveolar_FB|COVID-19 / group, cell type (main and fine annotations)

NAV3 TTC28 YAP1

8.66e-05195203603050beeb33c331d4b2e3fa46cae3f3e0e4bdc7
ToppCellIIH-mono3-|IIH / Condition, Cell_class and T cell subcluster

NAV3 CDK2AP1 GPR34

8.66e-0519520328a858b04a7b413916c07a8d880f5ea02e985461
ToppCellCOVID-19-Fibroblasts|COVID-19 / group, cell type (main and fine annotations)

NAV3 TTC28 YAP1

8.92e-05197203fb847f2277609c31fffcdf49517243ce0684facf
ToppCellCOVID-19-Fibroblasts-Intermediate_pathological_FB|COVID-19 / group, cell type (main and fine annotations)

NAV3 TTC28 YAP1

8.92e-05197203f1c8936986123a3151140c374fcd62d6705c530b
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Hematopoietic-Megakaryocytic-Megakaryocyte|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

MUC16 MUC3A YAP1

9.06e-0519820335edf6d5bedc2181fbdd56f43e458bc39f4eca16
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Hematopoietic-Megakaryocytic|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

MUC16 MUC3A YAP1

9.06e-05198203ff6d9455ebfe965cc6f48197172c0ebd3bddde81
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Hematopoietic-Megakaryocytic-Megakaryocyte-Mega|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

MUC16 MUC3A YAP1

9.06e-051982035cfd1c030c0940136a397b5a4b5d6ecbaecf72eb
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Hematopoietic|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

MUC16 MUC3A YAP1

9.06e-051982035375a2895cf995f0db4a61861093f01794707901
ToppCellNS-control|NS / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

MUC16 YAP1 DLG5

9.33e-05200203ecbe89ff95d046155b984c8c150e0b9e7278f839
Drugrioprostil

MUC3A MUC3B MUC12

3.30e-0632213CID005311413
Drugcellobiitol

MUC3A MUC3B MUC12

5.15e-0637213CID000003871
Druginulin

KCNK5 MUC3A MUC3B MUC12

6.17e-06133214CID000024763
DrugGastrin tetrapeptide

MUC3A MUC3B MUC12

1.29e-0550213CID000005415
Drugmucic acid

MUC3A MUC3B MUC12

7.06e-0588213CID000000607
Diseasecholangiocarcinoma (is_marker_for)

MUC16 MUC3A MUC6

1.26e-0564213DOID:4947 (is_marker_for)
Diseasecholesteryl ester 14:0 measurement

NAV3 MUSK

1.68e-0427212EFO_0010340
Diseaseserum alanine aminotransferase measurement

CDK2AP1 YAP1 DLG5 MUSK AFG1L

3.01e-04869215EFO_0004735
Diseaseheart rate response to exercise

MUC3A MUC3B

4.28e-0443212EFO_0009184
Diseaseplasminogen activator inhibitor 1 measurement

MUC17 MUC12

6.75e-0454212EFO_0004792
DiseaseHOMA-B

NAV3 MUSK

7.00e-0455212EFO_0004469
Diseasepancreatic cancer (is_marker_for)

MUC16 MUC6

2.33e-03101212DOID:1793 (is_marker_for)
Diseaseapolipoprotein A 1 measurement

CDK2AP1 KCNK5 MUC17 MUSK

2.74e-03848214EFO_0004614
DiseaseRS-10-hydroxywarfarin to RS-warfarin ratio measurement

MUC3A MUC3B

2.76e-03110212EFO_0803335
Diseaseintelligence, self reported educational attainment

CDK2AP1 AFG1L

3.12e-03117212EFO_0004337, EFO_0004784

Protein segments in the cluster

PeptideGeneStartEntry
ITMTTTSVSSWPYSS

GPR34

6

Q9UPC5
QTSESMTPTATSETY

AFG1L

51

Q8WV93
STMEDTSVSTSTPGF

MUC16

8091

Q8WXI7
EMESSVYQPTSSSST

MUC16

14306

Q8WXI7
TGPMTATSFQTTTTY

MUC6

1981

Q6W4X9
MGEFPSSSESTFTST

KCNK5

461

O95279
TSTYSMTTTEKGTSA

MUC3A

171

Q02505
ASSMTTSETTYPNSP

MUC3A

701

Q02505
YPTTMTETSSTATSL

MUC3A

1481

Q02505
STPSPTTTMSFTTFT

MUC3A

1696

Q02505
PSYQSMTSLHTSSES

NAV3

1361

Q8IVL0
AGSTYSVLSTMPSDS

DLG5

101

Q8TDM6
STAMGSSVPYSTAKT

NUP214

1136

P35658
TSTTYSSSARFMPGT

IFFO1

181

Q0D2I5
STMTPGQITYTATST

DEFB129

131

Q9H1M3
SVHSPSTSMATSSQY

CDK2AP1

21

O14519
SGQSSEVSTPSSLYM

RUBCN

436

Q92622
STTAEGTSMPTSTYS

MUC17

611

Q685J3
GTSMPTSTYSERGTT

MUC17

616

Q685J3
TSTYSERGTTITSMS

MUC17

621

Q685J3
TTAEGTSMPTSTYTE

MUC17

671

Q685J3
TSMQTSTYSEGSTPL

MUC17

1561

Q685J3
TADDTSMPTSTYSEG

MUC17

2381

Q685J3
ATSAEGTSMPTSTYS

MUC17

2556

Q685J3
DGTSMPTSTYSEGST

MUC17

3326

Q685J3
TTVTFGSMDSSTSTL

MUC3B

511

Q9H195
MSSTSTRSGSSDSSY

SARG

26

Q9BW04
FSSMTSDSDTTSPTG

ARHGAP25

396

P42331
ESTDSGLSMSSYSVP

YAP1

396

P46937
SSEYSSSSSSPMGVQ

ZCCHC14

416

Q8WYQ9
SSGYSSPTTSEMSIK

TTC28

2246

Q96AY4
ESTTYHSSPGSTQTM

MUC12

4551

Q9UKN1
SSSSSFSVSPTYSMT

MUSK

481

O15146