Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	neuron projection development	EFHC2 POSTN RIPOR2 CIB1 NF1 HMCN2 SNAP91 FEZ2 MTOR SYNE1 SIPA1L1 VASH2 DHFR2 APC AFDN SPAG9 RERE ADGRV1 FXN HOXA2	1.92e-07	1285	85	20	GO:0031175
GeneOntologyBiologicalProcess	neuron development	EFHC2 POSTN RIPOR2 CIB1 NF1 HMCN2 SNAP91 FEZ2 MTOR SYNE1 SIPA1L1 VASH2 DHFR2 APC AFDN SPAG9 RERE ADGRV1 FXN HOXA2	1.49e-06	1463	85	20	GO:0048666
GeneOntologyBiologicalProcess	regulation of organelle assembly	LRFN1 RIPOR2 FEZ2 MTOR SYNE1 SIPA1L1 ATM CNTROB	2.03e-05	280	85	8	GO:1902115
GeneOntologyBiologicalProcess	vesicle budding from membrane	TRAPPC13 MIA3 SNAP91 SEC31A TFG	3.72e-05	91	85	5	GO:0006900
GeneOntologyBiologicalProcess	neuron projection morphogenesis	POSTN HMCN2 SNAP91 FEZ2 SYNE1 SIPA1L1 APC AFDN SPAG9 RERE FXN HOXA2	1.07e-04	802	85	12	GO:0048812
GeneOntologyBiologicalProcess	plasma membrane bounded cell projection morphogenesis	POSTN HMCN2 SNAP91 FEZ2 SYNE1 SIPA1L1 APC AFDN SPAG9 RERE FXN HOXA2	1.30e-04	819	85	12	GO:0120039
GeneOntologyBiologicalProcess	cell projection morphogenesis	POSTN HMCN2 SNAP91 FEZ2 SYNE1 SIPA1L1 APC AFDN SPAG9 RERE FXN HOXA2	1.41e-04	826	85	12	GO:0048858
GeneOntologyBiologicalProcess	regulation of mini excitatory postsynaptic potential	SYNE1 AFDN	1.66e-04	5	85	2	GO:0061884
GeneOntologyBiologicalProcess	mini excitatory postsynaptic potential	SYNE1 AFDN	1.66e-04	5	85	2	GO:0098816
GeneOntologyBiologicalProcess	regulation of plasma membrane bounded cell projection organization	EFHC2 RIPOR2 CIB1 NF1 SNAP91 MTOR SYNE1 SIPA1L1 APC AFDN FXN CNTROB	1.76e-04	846	85	12	GO:0120035
GeneOntologyBiologicalProcess	regulation of cell projection organization	EFHC2 RIPOR2 CIB1 NF1 SNAP91 MTOR SYNE1 SIPA1L1 APC AFDN FXN CNTROB	2.11e-04	863	85	12	GO:0031344
GeneOntologyBiologicalProcess	organelle assembly	LRFN1 RIPOR2 FEZ2 MTOR SYNE1 SIPA1L1 MTERF3 RAB7B POGZ ATM ARMC2 CCDC38 CNTROB DDX28	2.16e-04	1138	85	14	GO:0070925
HumanPheno	Cafe-au-lait spot	CIB1 NF1 MTOR APC ATM RERE FANCM	1.34e-05	137	31	7	HP:0000957
HumanPheno	Multiple cafe-au-lait spots	CIB1 NF1 ATM RERE FANCM	3.53e-05	64	31	5	HP:0007565
HumanPheno	Abnormal glial cell morphology	GALC NF1 MTOR APC ATM RERE TFG	9.99e-05	187	31	7	HP:0100705
HumanPheno	Square-wave jerks	SYNE1 FXN	1.07e-04	3	31	2	HP:0025402
HumanPheno	Saccadic intrusion	SYNE1 FXN	1.07e-04	3	31	2	HP:0032114
HumanPheno	macules	GALC CIB1 NF1 MTOR APC ATM RERE FANCM	1.23e-04	262	31	8	HP:0200031
Domain	ARM-type_fold	AP4E1 NCAPD3 RIPOR2 NF1 MTOR VEPH1 INTS1 APC ATM ARMC2 VIRMA	3.86e-07	339	85	11	IPR016024
Domain	-	AP4E1 NCAPD3 RIPOR2 NF1 MTOR APC ARMC2	6.86e-05	222	85	7	1.25.10.10
Domain	FATC	MTOR ATM	2.03e-04	5	85	2	PF02260
Domain	ARM-like	AP4E1 NCAPD3 RIPOR2 NF1 MTOR APC ARMC2	2.31e-04	270	85	7	IPR011989
Domain	FAT	MTOR ATM	3.03e-04	6	85	2	PS51189
Domain	FATC	MTOR ATM	3.03e-04	6	85	2	PS51190
Domain	FAT	MTOR ATM	3.03e-04	6	85	2	PF02259
Domain	PIK-rel_kinase_FAT	MTOR ATM	3.03e-04	6	85	2	IPR003151
Domain	FATC_dom	MTOR ATM	3.03e-04	6	85	2	IPR003152
Domain	PIK_FAT	MTOR ATM	3.03e-04	6	85	2	IPR014009
Domain	FATC	MTOR ATM	3.03e-04	6	85	2	SM01343
Domain	Calx_beta	ADGRV1 FREM1	7.22e-04	9	85	2	IPR003644
Domain	Calx-beta	ADGRV1 FREM1	7.22e-04	9	85	2	PF03160
Domain	Helicase_C	HLTF FANCM POLQ DDX28	1.44e-03	107	85	4	PF00271
Domain	HELICc	HLTF FANCM POLQ DDX28	1.44e-03	107	85	4	SM00490
Domain	Helicase_C	HLTF FANCM POLQ DDX28	1.49e-03	108	85	4	IPR001650
Domain	HELICASE_CTER	HLTF FANCM POLQ DDX28	1.55e-03	109	85	4	PS51194
Domain	HELICASE_ATP_BIND_1	HLTF FANCM POLQ DDX28	1.55e-03	109	85	4	PS51192
Domain	DEXDc	HLTF FANCM POLQ DDX28	1.55e-03	109	85	4	SM00487
Domain	Helicase_ATP-bd	HLTF FANCM POLQ DDX28	1.60e-03	110	85	4	IPR014001
Domain	PI3/4_kinase_CS	MTOR ATM	2.07e-03	15	85	2	IPR018936
Domain	-	MTOR ATM	2.36e-03	16	85	2	1.10.1070.11
Domain	PI3Kc	MTOR ATM	2.36e-03	16	85	2	SM00146
Domain	PI3/4_kinase_cat_dom	MTOR ATM	2.99e-03	18	85	2	IPR000403
Domain	PI3_PI4_kinase	MTOR ATM	2.99e-03	18	85	2	PF00454
Domain	PI3_4_KINASE_3	MTOR ATM	2.99e-03	18	85	2	PS50290
Domain	PI3_4_KINASE_1	MTOR ATM	2.99e-03	18	85	2	PS00915
Domain	PI3_4_KINASE_2	MTOR ATM	2.99e-03	18	85	2	PS00916
Domain	CH	SYNE1 LRCH4 MICAL3	3.24e-03	65	85	3	SM00033
Domain	CH	SYNE1 LRCH4 MICAL3	4.00e-03	70	85	3	PF00307
Domain	-	SYNE1 LRCH4 MICAL3	4.16e-03	71	85	3	1.10.418.10
Domain	DEAD/DEAH_box_helicase_dom	FANCM POLQ DDX28	4.50e-03	73	85	3	IPR011545
Domain	CH	SYNE1 LRCH4 MICAL3	4.50e-03	73	85	3	PS50021
Domain	DEAD	FANCM POLQ DDX28	4.50e-03	73	85	3	PF00270
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	NCAPD3 EXO5 NF1 SIPA1L1 AFDN MICAL3 SPAG9 POGZ ATM PROSER2 RERE VIRMA	5.23e-07	774	87	12	15302935
Pubmed	A Network of Conserved Synthetic Lethal Interactions for Exploration of Precision Cancer Therapy.	NF1 IMPDH1 ATAD5 MTOR APC	6.40e-07	65	87	5	27453043
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	MIA3 LRFN1 NF1 SNAP91 MTOR OSBPL3 N4BP2 SYNE1 SIPA1L1 APC AFDN SEC31A VIRMA	8.00e-07	963	87	13	28671696
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	PDIA4 NCAPD3 NF1 PITRM1 MTOR SYNE1 ANP32A AFDN POGZ SEC31A ATM LTF CMYA5 CCDC38 TFG	2.35e-06	1425	87	15	30948266
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	PDIA4 NF1 MTOR INTS1 AFDN SPAG9 POGZ ATM LTF VIRMA	5.55e-06	653	87	10	22586326
Pubmed	The mouse genomic instability mutation chaos1 is an allele of Polq that exhibits genetic interaction with Atm.	ATM POLQ	6.19e-06	2	87	2	15542845
Pubmed	Rapamycin, a mTOR inhibitor, induced growth inhibition in retinoblastoma Y79 cell via down-regulation of Bmi-1.	BMI1 MTOR	6.19e-06	2	87	2	26191215
Pubmed	Periostin Promotes Colorectal Tumorigenesis through Integrin-FAK-Src Pathway-Mediated YAP/TAZ Activation.	POSTN APC	6.19e-06	2	87	2	31968254
Pubmed	Upregulation of mTORC2 activation by the selective agonist of EPAC, 8-CPT-2Me-cAMP, in prostate cancer cells: assembly of a multiprotein signaling complex.	RAPGEF3 MTOR	6.19e-06	2	87	2	22173835
Pubmed	Periostin responds to mechanical stress and tension by activating the MTOR signaling pathway.	POSTN MTOR	6.19e-06	2	87	2	24349533
Pubmed	Prognostic Significance of Periostin and Mammalian Target of Rapamycin (mTOR) in Locally Advanced Esophageal Squamous Cell Carcinoma.	POSTN MTOR	6.19e-06	2	87	2	28665915
Pubmed	NF1 patient missense variants predict a role for ATM in modifying neurofibroma initiation.	NF1 ATM	6.19e-06	2	87	2	31664505
Pubmed	Oncogenic mutations in adenomatous polyposis coli (Apc) activate mechanistic target of rapamycin complex 1 (mTORC1) in mice and zebrafish.	MTOR APC	6.19e-06	2	87	2	24092877
Pubmed	Hyperactivation of mTOR critically regulates abnormal osteoclastogenesis in neurofibromatosis Type 1.	NF1 MTOR	6.19e-06	2	87	2	21748792
Pubmed	Association of ATM and BMI-1 genetic variation with breast cancer risk in Han Chinese.	BMI1 ATM	6.19e-06	2	87	2	29691986
Pubmed	Atm is a negative regulator of intestinal neoplasia.	APC ATM	6.19e-06	2	87	2	17700532
Pubmed	Vasohibin-2 modulates tumor onset in the gastrointestinal tract by normalizing tumor angiogenesis.	VASH2 APC	6.19e-06	2	87	2	24885408
Pubmed	Identification of a novel protein kinase mediating Akt survival signaling to the ATM protein.	NUAK1 ATM	6.19e-06	2	87	2	12409306
Pubmed	CTDP1 regulates breast cancer survival and DNA repair through BRCT-specific interactions with FANCI.	NCAPD3 NF1 INTS1 MICAL3 ATM	6.60e-06	104	87	5	31240132
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	RIPOR2 SYNE1 SIPA1L1 MICAL3 POGZ RERE VIRMA SNX19	8.57e-06	407	87	8	12693553
Pubmed	Autism risk gene POGZ promotes chromatin accessibility and expression of clustered synaptic genes.	LRFN5 PCDH11X POGZ	1.00e-05	17	87	3	34879283
Pubmed	Colorectal Tumors Require NUAK1 for Protection from Oxidative Stress.	NUAK1 APC	1.85e-05	3	87	2	29500295
Pubmed	Arlm1 is a male-specific modifier of astrocytoma resistance on mouse Chr 12.	NF1 CDCA7L	1.85e-05	3	87	2	22234937
Pubmed	USP22 exerts tumor-suppressive functions in colorectal cancer by decreasing mTOR activity.	MTOR APC	1.85e-05	3	87	2	31527800
Pubmed	Epac1-induced cellular proliferation in prostate cancer cells is mediated by B-Raf/ERK and mTOR signaling cascades.	RAPGEF3 MTOR	1.85e-05	3	87	2	19725049
Pubmed	TANGO1 interacts with NRTN to promote hepatocellular carcinoma progression by regulating the PI3K/AKT/mTOR signaling pathway.	MIA3 MTOR	1.85e-05	3	87	2	37211171
Pubmed	BMI1 attenuates etoposide-induced G2/M checkpoints via reducing ATM activation.	BMI1 ATM	1.85e-05	3	87	2	25088203
Pubmed	ATM protein physically and functionally interacts with proliferating cell nuclear antigen to regulate DNA synthesis.	MTOR ATM	1.85e-05	3	87	2	22362778
Pubmed	Heterozygosity for a mutation in Brca1 or Atm does not increase susceptibility to ENU-induced mammary tumors in Apc(Min)/+ mice.	APC ATM	1.85e-05	3	87	2	11181458
Pubmed	Aberrant CD8+ T-cell responses and memory differentiation upon viral infection of an ataxia-telangiectasia mouse model driven by hyper-activated Akt and mTORC1 signaling.	MTOR ATM	1.85e-05	3	87	2	21641396
Pubmed	ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS.	MTOR ATM	1.85e-05	3	87	2	20160076
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	NCAPD3 SPCS3 IMPDH1 ATAD5 SYNE1 SIPA1L1 INTS1 LRCH4 HLTF APC AFDN VIRMA AHDC1 DDX28	2.01e-05	1497	87	14	31527615
Pubmed	mTOR drives its own activation via SCF(βTrCP)-dependent degradation of the mTOR inhibitor DEPTOR.	MTOR SIPA1L1 FANCM	2.58e-05	23	87	3	22017875
Pubmed	Combinatorial CRISPR-Cas9 screens for de novo mapping of genetic interactions.	NF1 MTOR APC ATM	3.12e-05	71	87	4	28319113
Pubmed	Functional coupling of presequence processing and degradation in human mitochondria.	PITRM1 MIPEP	3.70e-05	4	87	2	32491259
Pubmed	Loss of HLTF function promotes intestinal carcinogenesis.	HLTF APC	3.70e-05	4	87	2	22452792
Pubmed	p38 MAPK-Mediated Bmi-1 down-regulation and defective proliferation in ATM-deficient neural stem cells can be restored by Akt activation.	BMI1 ATM	3.70e-05	4	87	2	21305053
Pubmed	Involvement of the telomeric protein Pin2/TRF1 in the regulation of the mitotic spindle.	APC ATM	3.70e-05	4	87	2	11943150
Pubmed	MAF mediates crosstalk between Ras-MAPK and mTOR signaling in NF1.	NF1 MTOR	3.70e-05	4	87	2	24509877
Pubmed	p53 and NF 1 loss plays distinct but complementary roles in glioma initiation and progression.	NF1 MTOR	3.70e-05	4	87	2	29392777
Pubmed	ANP32A regulates ATM expression and prevents oxidative stress in cartilage, brain, and bone.	ANP32A ATM	3.70e-05	4	87	2	30209244
Pubmed	mTORC1 signaling under hypoxic conditions is controlled by ATM-dependent phosphorylation of HIF-1α.	MTOR ATM	3.70e-05	4	87	2	21095582
Pubmed	Mammalian target of rapamycin-dependent acinar cell neoplasia after inactivation of Apc and Pten in the mouse salivary gland: implications for human acinic cell carcinoma.	MTOR APC	3.70e-05	4	87	2	21062985
Pubmed	Tumor microenvironment confers mTOR inhibitor resistance in invasive intestinal adenocarcinoma.	MTOR APC	3.70e-05	4	87	2	28759045
Pubmed	The SALM/Lrfn family of leucine-rich repeat-containing cell adhesion molecules.	LRFN1 LRFN5	3.70e-05	4	87	2	21736948
Pubmed	Validation and structural characterization of the LEDGF/p75-MLL interface as a new target for the treatment of MLL-dependent leukemia.	POGZ CDCA7L	3.70e-05	4	87	2	25082813
Pubmed	Bmi1 is required for tumorigenesis in a mouse model of intestinal cancer.	BMI1 APC	3.70e-05	4	87	2	23955081
Pubmed	5-HT(6) receptor recruitment of mTOR as a mechanism for perturbed cognition in schizophrenia.	NF1 MTOR ATM	4.23e-05	27	87	3	23027611
Pubmed	Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro.	N4BP2 INTS1 PCDH11X MICAL3 VIRMA	4.26e-05	153	87	5	10718198
Pubmed	BMI1 confers radioresistance to normal and cancerous neural stem cells through recruitment of the DNA damage response machinery.	BMI1 ATM	6.16e-05	5	87	2	20668194
Pubmed	Multiple cellular proteins interact with LEDGF/p75 through a conserved unstructured consensus motif.	POGZ CDCA7L	6.16e-05	5	87	2	26245978
Pubmed	Tumor-initiating stem cell shapes its microenvironment into an immunosuppressive barrier and pro-tumorigenic niche.	BMI1 APC	6.16e-05	5	87	2	34496236
Pubmed	A High-Density Human Mitochondrial Proximity Interaction Network.	PDIA4 NBAS SPCS3 MIA3 PITRM1 OSBPL3 SYNE1 MTERF3 MIPEP SPAG9 RERE SNX19 DDX28	8.64e-05	1496	87	13	32877691
Pubmed	Large-scale concatenation cDNA sequencing.	NCAPD3 NF1 SNAP91 RAPGEF3 ANP32A PCDH11X APC AHDC1	9.08e-05	568	87	8	9110174
Pubmed	Spatiotemporal reprogramming of differentiated cells underlies regeneration and neoplasia in the intestinal epithelium.	BMI1 APC	9.22e-05	6	87	2	35314700
Pubmed	TANGO1 recruits Sec16 to coordinately organize ER exit sites for efficient secretion.	MIA3 SEC31A	9.22e-05	6	87	2	28442536
Pubmed	Reactive nitrogen species regulate autophagy through ATM-AMPK-TSC2-mediated suppression of mTORC1.	MTOR ATM	9.22e-05	6	87	2	23878245
Pubmed	PAF-Myc-Controlled Cell Stemness Is Required for Intestinal Regeneration and Tumorigenesis.	BMI1 APC	9.22e-05	6	87	2	29533773
Pubmed	Ranking novel cancer driving synthetic lethal gene pairs using TCGA data.	MTOR ATM	9.22e-05	6	87	2	27438146
Pubmed	Partial inhibition of gp130-Jak-Stat3 signaling prevents Wnt-β-catenin-mediated intestinal tumor growth and regeneration.	BMI1 APC	9.22e-05	6	87	2	25270258
Pubmed	Nuclear Gene 33/Mig6 regulates the DNA damage response through an ATM serine/threonine kinase-dependent mechanism.	ERRFI1 ATM	9.22e-05	6	87	2	28842482
Pubmed	A "double adaptor" method for improved shotgun library construction.	NCAPD3 NF1 SNAP91 RAPGEF3 ANP32A PCDH11X APC AHDC1	9.77e-05	574	87	8	8619474
Pubmed	An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.	EFHC2 POSTN GALC LRFN1 NF1 PITRM1 MTOR OSBPL3 SIPA1L1 AFDN PDE5A SPAG9	1.10e-04	1321	87	12	27173435
Pubmed	HSF1 phosphorylation establishes an active chromatin state via the TRRAP-TIP60 complex and promotes tumorigenesis.	S100A7 SPCS3 LRFN1 SYNE1 HLTF SEC31A PROSER2 LTF CNTROB	1.15e-04	754	87	9	35906200
Pubmed	Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer.	OSBPL3 SIPA1L1 ERRFI1 APC	1.29e-04	102	87	4	15778465
Pubmed	Tumor suppressor gene mutations in mice.	NF1 APC	1.29e-04	7	87	2	8982467
Pubmed	Comparative analysis of structure, expression and PSD95-binding capacity of Lrfn, a novel family of neuronal transmembrane proteins.	LRFN1 LRFN5	1.29e-04	7	87	2	16828986
Pubmed	Identification of a PP2A-interacting protein that functions as a negative regulator of phosphatase activity in the ATM/ATR signaling pathway.	ATM ITFG1	1.29e-04	7	87	2	17384681
Pubmed	MCM9 deficiency delays primordial germ cell proliferation independent of the ATM pathway.	ATM FANCM	1.29e-04	7	87	2	26388201
Pubmed	The neurofibromin GAP-related domain rescues endothelial but not neural crest development in Nf1 mice.	NF1 MTOR	1.29e-04	7	87	2	16906226
Pubmed	Monoubiquitination of H2AX protein regulates DNA damage response signaling.	BMI1 ATM	1.29e-04	7	87	2	21676867
Pubmed	Affinity switching of the LEDGF/p75 IBD interactome is governed by kinase-dependent phosphorylation.	POGZ CDCA7L	1.29e-04	7	87	2	29997176
Pubmed	Polycomb subunit BMI1 determines uterine progesterone responsiveness essential for normal embryo implantation.	BMI1 LTF	1.29e-04	7	87	2	29202468
Pubmed	Neurofibromatosis-1 regulates mTOR-mediated astrocyte growth and glioma formation in a TSC/Rheb-independent manner.	NF1 MTOR	1.29e-04	7	87	2	21896734
Pubmed	Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.	MIA3 NF1 SIPA1L1 LRCH4 APC AFDN CNTROB	1.32e-04	446	87	7	24255178
Pubmed	Systematic analysis of human protein complexes identifies chromosome segregation proteins.	PDIA4 NBAS PHF20L1 SYNE1 APC MICAL3 SPAG9 POGZ ATM LTF DDX28	1.44e-04	1155	87	11	20360068
Pubmed	mTORC1 Inactivation Promotes Colitis-Induced Colorectal Cancer but Protects from APC Loss-Dependent Tumorigenesis.	MTOR APC	1.72e-04	8	87	2	29275959
Pubmed	Distinct Roles of HES1 in Normal Stem Cells and Tumor Stem-like Cells of the Intestine.	BMI1 APC	1.72e-04	8	87	2	28536281
Pubmed	Loss-of-function mutations in TBC1D20 cause cataracts and male infertility in blind sterile mice and Warburg micro syndrome in humans.	PDIA4 SEC31A	1.72e-04	8	87	2	24239381
Pubmed	A genetic screen identifies the Triple T complex required for DNA damage signaling and ATM and ATR stability.	MTOR ATM	1.72e-04	8	87	2	20810650
Pubmed	A class of circadian long non-coding RNAs mark enhancers modulating long-range circadian gene regulation.	ERRFI1 RERE	1.72e-04	8	87	2	28335007
Pubmed	The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.	PDIA4 NCAPD3 SPCS3 MIA3 INTS1 AFDN POGZ LTF RERE VIRMA ITFG1	2.05e-04	1203	87	11	29180619
Pubmed	Hypersensitivity of primordial germ cells to compromised replication-associated DNA repair involves ATM-p53-p21 signaling.	ATM FANCM	2.20e-04	9	87	2	25010009
Pubmed	Role of Gadd45a in Wip1-dependent regulation of intestinal tumorigenesis.	APC ATM	2.20e-04	9	87	2	22555459
Pubmed	Proteomic analysis reveals GIT1 as a novel mTOR complex component critical for mediating astrocyte survival.	NF1 MTOR	2.20e-04	9	87	2	27340174
Pubmed	Small molecule inhibitors uncover synthetic genetic interactions of human flap endonuclease 1 (FEN1) with DNA damage response genes.	HLTF ATM	2.20e-04	9	87	2	28628639
Pubmed	A human MAP kinase interactome.	RIPOR2 N4BP2 SYNE1 ERRFI1 APC POGZ SEC31A	2.22e-04	486	87	7	20936779
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	NCAPD3 MIA3 OSBPL3 LRCH4 HLTF APC AFDN MICAL3	2.28e-04	650	87	8	38777146
Pubmed	Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations.	NF1 OXR1 SNAP91 SIPA1L1 APC MICAL3	2.42e-04	347	87	6	17114649
Pubmed	Tel2 regulates the stability of PI3K-related protein kinases.	MTOR ATM	2.75e-04	10	87	2	18160036
Pubmed	Comparative Protein Interaction Network Analysis Identifies Shared and Distinct Functions for the Human ROCO Proteins.	PHF20L1 RAPGEF3 FANCM CNTROB AHDC1	2.88e-04	230	87	5	29513927
Pubmed	Relevance Rank Platform (RRP) for Functional Filtering of High Content Protein-Protein Interaction Data.	PDIA4 SYNE1 CMYA5	3.06e-04	52	87	3	26499835
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	NF1 MTOR OSBPL3 N4BP2 SIPA1L1 APC AFDN PROSER2 VIRMA	3.07e-04	861	87	9	36931259
Pubmed	Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV.	NCAPD3 LRFN1 NF1 PITRM1 TAMM41 INTS1 MIPEP SPAG9 SEC31A ATM	3.20e-04	1061	87	10	33845483
Pubmed	A Single Adaptable Cochaperone-Scaffold Complex Delivers Nascent Iron-Sulfur Clusters to Mammalian Respiratory Chain Complexes I-III.	NBAS NCAPD3 SPCS3 PITRM1 TAMM41 MIPEP MICAL3 DDX28	3.27e-04	686	87	8	28380382
Pubmed	Tti1 and Tel2 are critical factors in mammalian target of rapamycin complex assembly.	MTOR ATM	3.35e-04	11	87	2	20427287
Pubmed	Folate Metabolism Regulates Oligodendrocyte Survival and Differentiation by Modulating AMPKα Activity.	DHFR2 APC	3.35e-04	11	87	2	28496133
Pubmed	Pro-prion, as a membrane adaptor protein for E3 ligase c-Cbl, facilitates the ubiquitination of IGF-1R, promoting melanoma metastasis.	S100A7 NCAPD3 IMPDH1 OSBPL3 MTERF3 INTS1 APC SEC31A	3.37e-04	689	87	8	36543142
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	S100A7 SPCS3 GALC SYNE1 INTS1 APC POGZ SEC31A ATM AHDC1	3.73e-04	1082	87	10	38697112
Pubmed	Specific pupylation as IDEntity reporter (SPIDER) for the identification of protein-biomolecule interactions.	PDIA4 S100A7 POSTN	3.81e-04	56	87	3	37059927
Interaction	KCTD3 interactions	BMI1 LRFN1 NF1 OSBPL3 SIPA1L1 AFDN VIRMA	7.03e-06	164	87	7	int:KCTD3
Interaction	FAM110B interactions	LRFN1 NF1 SIPA1L1 AFDN VIRMA	1.04e-05	67	87	5	int:FAM110B
Interaction	STARD13 interactions	S100A7 LRFN1 NF1 SIPA1L1 VIRMA	1.12e-05	68	87	5	int:STARD13
Interaction	WEE1 interactions	IMPDH1 ATAD5 MTOR ERRFI1 SPAG9 VIRMA	2.40e-05	133	87	6	int:WEE1
Cytoband	8q23	OXR1 NUDCD1	5.33e-04	18	87	2	8q23
Cytoband	Ensembl 112 genes in cytogenetic band chr7p15	OSBPL3 CDCA7L HOXA2	9.58e-04	101	87	3	chr7p15
Cytoband	11q25	NCAPD3 SNX19	1.12e-03	26	87	2	11q25
Cytoband	Ensembl 112 genes in cytogenetic band chr11q25	NCAPD3 SNX19	1.59e-03	31	87	2	chr11q25
Cytoband	8q22.1	MTERF3 VIRMA	2.64e-03	40	87	2	8q22.1
GeneFamily	Fibronectin type III domain containing	FSD1L LRFN1 LRFN5 CMYA5	9.18e-04	160	49	4	555
Coexpression	GSE42021_TREG_PLN_VS_CD24LO_TREG_THYMUS_UP	AP4E1 NF1 IMPDH1 OXR1 RAPGEF3 HLTF AFDN ADGRV1	2.99e-07	196	87	8	M9578
ToppCell	renal_medulla_nuclei\|World / Celltypes from Cells and Nuclei per compartment and clinical group	OXR1 OSBPL3 SYNE1 VEPH1 RERE FREM1	1.93e-06	189	87	6	830d9cd0dd706bce22eb2416f07b2c31c870a05a
ToppCell	COVID-19_Severe-immature_Neutrophil\|COVID-19_Severe / Disease condition and Cell class	ATAD5 SYNE1 VEPH1 LTF POLQ CDCA7L	2.60e-06	199	87	6	f82fa9d651e78f9ebbe6264e00a48c54b1786a69
ToppCell	COVID-19_Severe-immature_Neutrophil-\|COVID-19_Severe / Disease condition and Cell class	ATAD5 SYNE1 VEPH1 LTF POLQ CDCA7L	2.60e-06	199	87	6	42ea0c19c455bdb0ae89b428d09c333104c670dc
ToppCell	droplet-Lung-immune-endo-depleted-3m-Lymphocytic-Proliferating_NK\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OSBPL3 ATM FXN POLQ CNTROB	2.15e-05	171	87	5	1eebd7138c3b20ddc1104f21615f9df0e776bbe6
ToppCell	PND14-Immune-Immune_Myeloid-DC-cDC1-cDC1_prolif\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SPCS3 ATAD5 HLTF RAB7B CDCA7L	2.34e-05	174	87	5	09b091e24317c3f7bac043f04762a533e30793de
ToppCell	facs-Marrow-B-cells-18m-Hematologic-MPP_Fraction_B_+_C\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PITRM1 FEZ2 MTERF3 HLTF POGZ	2.75e-05	180	87	5	7368ab31c3273374ef260f0d710d4eea83cbc4a2
ToppCell	CV-Healthy-7\|CV / Virus stimulation, Condition and Cluster	AP4E1 MICAL3 TUBD1 CNTROB CDCA7L	3.05e-05	184	87	5	0e5cc77aaa73ceb791f8be7456177577fd2e5586
ToppCell	droplet-Marrow-nan-21m-Lymphocytic-naive_T_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PDIA4 IMPDH1 RAPGEF3 RAB7B CDCA7L	3.21e-05	186	87	5	744bf39af2fb5a7454477174d7755a6d78cd279f
ToppCell	LPS-antiTNF-Epithelial_alveolar-AT_1-Differentiating_AT2\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	FSD1L OSBPL3 VEPH1 ERRFI1 ADGRV1	3.30e-05	187	87	5	58d48128547ee3513d0bf7f78e61b76b1c472ca9
ToppCell	droplet-Marrow-nan-18m-Lymphocytic-naive_T_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PDIA4 SPCS3 IMPDH1 RAPGEF3 CDCA7L	3.38e-05	188	87	5	1b349618f77260564486586b7f5a47a77d12859c
ToppCell	LPS-IL1RA-Epithelial_alveolar-AT_1-AT2_Progenitor\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PDIA4 FSD1L OSBPL3 VEPH1 ERRFI1	3.47e-05	189	87	5	5f883ef4cc0383142d538ae61f4fb40dfdb8ef18
ToppCell	LPS_IL1RA-Epithelial_alveolar-AT_1-Differentiating_AT2\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	OSBPL3 VEPH1 ERRFI1 PCDH11X ADGRV1	4.22e-05	197	87	5	b94645d57efe8d9e032bffb8c89af1f425c6421e
ToppCell	LPS_anti-TNF-Epithelial_alveolar-AT_1-Differentiating_AT2\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	FSD1L VEPH1 ERRFI1 PCDH11X ADGRV1	4.22e-05	197	87	5	3d13a4f2e86422900ee2194e8a1fd1cf9750d5d3
ToppCell	LPS_IL1RA-Epithelial_alveolar-AT_2-Differentiating_AT2\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	PDIA4 FSD1L VEPH1 ERRFI1 ADGRV1	4.33e-05	198	87	5	285f729140b1df029c24f6ca1d2438470ac51794
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	OXR1 SNAP91 LRFN5 SYNE1 PCDH11X	4.33e-05	198	87	5	8ab40fae14fe02e39bc8c8da187a5cd60c787643
ToppCell	LPS_only-Epithelial_alveolar-AT_1-Differentiating_AT1\|LPS_only / Treatment groups by lineage, cell group, cell type	FSD1L OSBPL3 VEPH1 ERRFI1 AFDN	4.54e-05	200	87	5	2dadf317a42a7e27cc1fac74f91b806c93a57108
ToppCell	Tracheal-NucSeq-Stromal-Fibroblastic-Fibro_perichondrial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	NUAK1 LRFN5 SYNE1 VEPH1 PCDH11X	4.54e-05	200	87	5	a4ec0e80f5422b91b85264a9bb74568dd577e285
ToppCell	356C-Endothelial_cells-Endothelial-A_(Artery)\|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)	PDIA4 POSTN CSRNP1 NUAK1 RAPGEF3	4.54e-05	200	87	5	89eae23195d57f1b23a337ff19c9b8a367e22c96
ToppCell	Severe-Developping_Plasmablast\|Severe / disease group and sub_cluster of B and Plasma cells(res = 0.5)	PDIA4 NCAPD3 SPCS3 ATAD5 POLQ	4.54e-05	200	87	5	6d0cd00e52568d23597cc2a4059bd967d7d2dab5
ToppCell	severe-immature_Neutrophil\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	SYNE1 VEPH1 LTF POLQ CDCA7L	4.54e-05	200	87	5	5ee43386da8261d2e7602a152e6ba4338d844e08
ToppCell	356C-Endothelial_cells-Endothelial-A_(Artery)-\|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)	PDIA4 POSTN CSRNP1 NUAK1 RAPGEF3	4.54e-05	200	87	5	fa99901388eec28004bef85d84f0d7d5bd4df4a8
Disease	Intellectual Disability	AP4E1 NF1 OXR1 PITRM1 MTOR SYNE1 APC POGZ TFG	5.77e-06	447	85	9	C3714756
Disease	Hematochezia	APC LTF	4.90e-05	4	85	2	C0018932
Disease	Glioblastoma	BMI1 NF1 MTOR APC	8.17e-05	79	85	4	C0017636
Disease	unipolar depression, bipolar disorder	SPCS3 OSBPL3 LRFN5 SYNE1 RERE	9.04e-05	156	85	5	EFO_0003761, MONDO_0004985
Disease	Giant Cell Glioblastoma	BMI1 NF1 MTOR APC	1.04e-04	84	85	4	C0334588
Disease	thalamus volume	GALC RIPOR2 NUAK1 ADGRV1	1.09e-04	85	85	4	EFO_0006935
Disease	Glioma	BMI1 NF1 APC ATM	1.19e-04	87	85	4	C0017638
Disease	obsessive-compulsive disorder, attention deficit hyperactivity disorder, Tourette syndrome, unipolar depression, bipolar disorder, autism spectrum disorder, schizophrenia, anorexia nervosa	SNAP91 OSBPL3 LRFN5 RERE SNX19	2.88e-04	200	85	5	EFO_0003756, EFO_0003761, EFO_0003888, EFO_0004242, EFO_0004895, MONDO_0004985, MONDO_0005090, MONDO_0005351
Disease	Gastrointestinal Hemorrhage	APC LTF	2.91e-04	9	85	2	C0017181
Disease	Glioblastoma Multiforme	BMI1 NF1 MTOR APC	3.04e-04	111	85	4	C1621958
Disease	Malignant Neoplasms	MTOR APC ATM LTF	5.21e-04	128	85	4	C0006826
Disease	Neoplasm of uncertain or unknown behavior of bladder	MTOR ATM	8.40e-04	15	85	2	C0496930
Disease	Benign neoplasm of bladder	MTOR ATM	8.40e-04	15	85	2	C0154017
Disease	Carcinoma in situ of bladder	MTOR ATM	8.40e-04	15	85	2	C0154091
Disease	Colorectal Carcinoma	POSTN NF1 SH3TC1 SYNE1 ANP32A PCDH11X APC TFG	9.49e-04	702	85	8	C0009402
Disease	Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse	MTOR ATM	9.59e-04	16	85	2	C0334634
Disease	Benign neoplasm of stomach	APC ATM	1.08e-03	17	85	2	C0153943
Disease	Eye Abnormalities	APC FREM1	1.08e-03	17	85	2	C0015393
Disease	Neoplasm of uncertain or unknown behavior of stomach	APC ATM	1.08e-03	17	85	2	C0496905
Disease	Carcinoma in situ of stomach	APC ATM	1.08e-03	17	85	2	C0154060
Disease	Carcinoma of bladder	MTOR ATM	1.22e-03	18	85	2	C0699885
Disease	Colorectal Neoplasms	POSTN SH3TC1 SYNE1 ANP32A APC	1.25e-03	277	85	5	C0009404
Disease	serum albumin measurement	SPCS3 MIA3 MIPEP MICAL3 SPAG9 ADGRV1 ARMC2	1.62e-03	592	85	7	EFO_0004535
Disease	Stomach Carcinoma	APC ATM	1.66e-03	21	85	2	C0699791
Disease	congestive heart failure (is_marker_for)	POSTN RAPGEF3 MTOR	1.73e-03	82	85	3	DOID:6000 (is_marker_for)
Disease	lymphocyte count, response to vaccine	NBAS OSBPL3	1.82e-03	22	85	2	EFO_0004587, EFO_0004645
Disease	Immunologic Deficiency Syndromes	NBAS ATM	1.99e-03	23	85	2	C0021051
Disease	nevus count, cutaneous melanoma	MIA3 ATM ADGRV1	2.33e-03	91	85	3	EFO_0000389, EFO_0004632
Disease	refractive error	SNAP91 LRFN5 PDE5A ATM CNTROB	2.55e-03	326	85	5	MONDO_0004892
Disease	Hereditary Nonpolyposis Colorectal Neoplasms	APC ATM	2.55e-03	26	85	2	C0009405
Disease	mean fractional anisotropy measurement	TRAPPC13 NUAK1 KIAA1614	2.64e-03	95	85	3	EFO_0008399

Protein segments in the cluster

Peptide	Gene	Start	Entry
EFRESSEDSFLSAII	AFDN	606	P55196
VILDDSDLFDTDLDF	ATAD5	1571	Q96QE3
IDVDTEFLASFSTEG	BPIFB4	521	P59827
LSSFLDEELALDGSF	ARMC2	811	Q8NEN0
DDAEFELTETFNISL	ADGRV1	3991	Q8WXG9
LSSEFDITEDFLSTS	ADGRV1	4686	Q8WXG9
GLTDEFEELEFLSTI	ANP32A	36	P39687
ESSLTADLLSVDAFA	SNAP91	606	O60641
RSLLDSDDSSDLLDF	AHDC1	841	Q5TGY3
FSLTSELLDSESLTE	AP4E1	846	Q9UPM8
LLAEDSFDESDFSEI	PGBD4	21	Q96DM1
LAFDVTDLESFEALD	RAB7B	86	Q96AH8
ELEECDIFFEESSSL	NUDCD1	406	Q96RS6
AFDFLSEETEASLAS	SPAG9	606	O60271
ESTDEFSELSFRISE	LRCH4	316	O75427
TAFDDVFALEELDLS	LRFN5	141	Q96NI6
SDSEFLEFLDLEDAQ	EXO5	21	Q9H790
ERLAEETLDSLAEFF	FXN	96	Q16595
ETLDSLAEFFEDLAD	FXN	101	Q16595
LSFSEDSDLSSDDVL	MICAL3	1791	Q7RTP6
LEELLTAFFSATADA	INTS1	1556	Q8N201
VDDDSLARILSFSDS	CSRNP1	386	Q96S65
LSELDEEFDSLYSIL	FSD1L	76	Q9BXM9
DFSAAFEILSREEEA	HMCN2	2746	Q8NDA2
AFDAFLSTVEDLDLS	LRFN1	156	Q9P244
FTLEELDEFTFVDET	KIAA1109	1856	Q2LD37
DESLLLFEDVNTEFD	FANCM	1131	Q8IYD8
LFEDVNTEFDDVSLS	FANCM	1136	Q8IYD8
EADLDSTSLTSEEVF	KIAA1614	251	Q5VZ46
TDDEIISLSIEFFDQ	BMI1	126	P35226
SDDLLESLLSRFEDS	EFHC2	671	Q5JST6
ITDFSFSDFELSDLE	PDE5A	556	O76074
FSDFELSDLETALCT	PDE5A	561	O76074
DSESLADDFTIQLSD	FREM1	1241	Q5H8C1
FSLDDSEIEDSLTEA	VEPH1	21	Q14D04
SFLVLDEADTLLDES	DDX28	281	Q9NUL7
RIFIEDTDSETEDFA	CDCA7L	71	Q96GN5
TLSILDENDDFTIDS	PCDH11X	606	Q9BZA7
EFLFTDSGLSTLEIE	NBAS	1706	A2RRP1
FIDFIADEVDLTSAL	IMPDH1	41	P20839
TEESLSEDVFTESEL	OXR1	331	Q8N573
LLVSTDREDFFAVSD	MON1A	491	Q86VX9
TSAAATSELEEILDF	BTBD18	486	B2RXH4
EELSFSEVEELFLQT	ATM	641	Q13315
SFTSSDDIAEVLFLE	POLQ	2126	O75417
AEELDEAVFLTSFEE	CMYA5	3646	Q8N3K9
SFGSEDSLEFLLDDE	CCDC38	311	Q502W7
QDFESDTFFSEIDLE	DHFR2	141	Q86XF0
DDFLTSDEEVDSVLF	HLTF	46	Q14527
DGSFTLSLHEDELFT	GALC	451	P54803
REEDSFDSDSTATLL	CNTROB	131	Q8N137
VSDSLLFDTSDDEEL	FEZ2	126	Q9UHY8
DSLSEFFDAQEVLLS	OSBPL3	446	Q9H4L5
ISSFDSELFLEELDE	MTERF3	101	Q96E29
VDFLDDSSTESLLLS	PHF20L1	641	A8MW92
ADSLDFFTDTLTTID	HOXA2	356	O43364
LETVDRLTESLDFTD	MTOR	1136	P42345
AFIRESTVFEDLSDE	LTF	226	P02788
FLSFSSLESLSSELE	SYNE1	1366	Q8NF91
ETTRLVTSLEDDFDE	MIA3	291	Q5JRA6
VLLFFEETIDSLDED	PROSER2	61	Q86WR7
DEISLFLDTEVLSSD	POGZ	1126	Q7Z3K3
DITDTFEAFTLSLLS	PITRM1	336	Q5JRX3
SDLGFITFDITADLE	SPCS3	61	P61009
SDITISELDVDSFDE	SIPA1L1	176	O43166
LSSVFRSFSDEEELT	SH3TC1	526	Q8TE82
SVLSSDSFDLLDLQE	NUAK1	576	O60285
EEFDSDTLREFVTAF	PDIA4	491	P13667
EFLDLSSASEDDFDS	RERE	481	Q9P2R6
VEFLTSSDTDFLLED	ERRFI1	171	Q9UJM3
LESFDFLNTSDFDEE	RIPOR2	661	Q9Y4F9
GSFETTADDIIDSLF	MC2R	96	Q01718
SLSSLDFDDDDVDLS	APC	1861	P25054
LSFEDFLDLLSVFSD	CIB1	86	Q99828
LDASELLSDTFEVLS	NCAPD3	1136	P42695
IEEEDFLDSFTSLEQ	TUBD1	431	Q9UJT1
LTNSEESLDFSESLE	RAPGEF3	76	O95398
DDFVSALVSDLDLDF	MIPEP	691	Q99797
EDGDLITIFDSSDLS	TFG	61	Q92734
DFSEFLSLLGDIATD	S100A7	71	P31151
TEFDTLAETVLADRF	NF1	1191	P21359
TFRTLSDLIFDFEDS	VASH2	221	Q86V25
EFLDLSASVEESAAT	SNX19	961	Q92543
SFSEEDLFIEIAGLS	TAMM41	171	Q96BW9
FFSLLSDIISSEDEE	TRDN	106	Q13061
DLTEDFTADLFLTTL	ITFG1	211	Q8TB96
SIQDFIEAEDDLSSF	POSTN	236	Q15063
TFSTNASLEIFELDL	SEC31A	36	O94979
AESDLSSVTDEVFLE	TRAPPC13	181	A5PLN9
SDFDLHSELERSFLS	VIRMA	1561	Q69YN4
EEEDSLDLSSTFVSL	TTC31	226	Q49AM3
DQEELFTSISEIFSD	N4BP2	46	Q86UW6