Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	cis-regulatory region sequence-specific DNA binding	ZNF444 ZNF263 NFE4 ZNF358 MYT1 ZNF581 TFAP2A ZKSCAN5 TFAP2C ZNF697 TBX2	2.49e-04	1271	50	11	GO:0000987
MousePheno	abnormal cardiac outflow tract development	HSPG2 MEGF8 DVL2 TFAP2A TBX2	3.33e-05	134	39	5	MP:0006126
Domain	SAM_1	SASH1 INPPL1 PPFIA1 L3MBTL3	2.77e-05	68	48	4	PF00536
Domain	TF_AP2	TFAP2A TFAP2C	6.44e-05	5	48	2	IPR004979
Domain	TF_AP2_C	TFAP2A TFAP2C	6.44e-05	5	48	2	IPR013854
Domain	TF_AP-2	TFAP2A TFAP2C	6.44e-05	5	48	2	PF03299
Domain	SAM	SASH1 INPPL1 PPFIA1 L3MBTL3	7.64e-05	88	48	4	SM00454
Domain	SAM_DOMAIN	SASH1 INPPL1 PPFIA1 L3MBTL3	1.03e-04	95	48	4	PS50105
Domain	SAM	SASH1 INPPL1 PPFIA1 L3MBTL3	1.12e-04	97	48	4	IPR001660
Domain	ZF_CCHHC	MYT1 L3MBTL3	1.35e-04	7	48	2	PS51802
Domain	-	SASH1 INPPL1 PPFIA1 L3MBTL3	1.57e-04	106	48	4	1.10.150.50
Domain	SAM_2	SASH1 INPPL1 PPFIA1	1.83e-04	43	48	3	PF07647
Domain	SAM/pointed	SASH1 INPPL1 PPFIA1 L3MBTL3	2.30e-04	117	48	4	IPR013761
Domain	SCAN	ZNF444 ZNF263 ZKSCAN5	4.01e-04	56	48	3	SM00431
Domain	SCAN_BOX	ZNF444 ZNF263 ZKSCAN5	4.45e-04	58	48	3	PS50804
Domain	SCAN	ZNF444 ZNF263 ZKSCAN5	4.45e-04	58	48	3	PF02023
Domain	SCAN_dom	ZNF444 ZNF263 ZKSCAN5	4.45e-04	58	48	3	IPR003309
Domain	Retrov_capsid_C	ZNF444 ZNF263 ZKSCAN5	4.68e-04	59	48	3	IPR008916
Domain	ArfGap	ACAP1 ACAP3	2.51e-03	29	48	2	SM00105
Domain	ArfGap	ACAP1 ACAP3	2.51e-03	29	48	2	PF01412
Domain	ARFGAP	ACAP1 ACAP3	2.51e-03	29	48	2	PS50115
Domain	ArfGAP	ACAP1 ACAP3	2.51e-03	29	48	2	IPR001164
Domain	-	ACAP1 ACAP3	2.69e-03	30	48	2	1.20.1270.60
Domain	AH/BAR-dom	ACAP1 ACAP3	2.69e-03	30	48	2	IPR027267
Domain	EGF_LAM_2	HSPG2 MEGF8	2.69e-03	30	48	2	PS50027
Domain	EGF_LAM_1	HSPG2 MEGF8	2.69e-03	30	48	2	PS01248
Domain	Laminin_EGF	HSPG2 MEGF8	3.65e-03	35	48	2	PF00053
Domain	EGF_Lam	HSPG2 MEGF8	3.65e-03	35	48	2	SM00180
Domain	Laminin_EGF	HSPG2 MEGF8	4.29e-03	38	48	2	IPR002049
Domain	PH	ACAP1 PLEKHG6 TEX2 ACAP3	5.59e-03	278	48	4	SM00233
Domain	UBA	USP24 RHBDD3	5.71e-03	44	48	2	IPR015940
Domain	PH_domain	ACAP1 PLEKHG6 TEX2 ACAP3	5.73e-03	280	48	4	IPR001849
Domain	UBA	USP24 RHBDD3	6.49e-03	47	48	2	PS50030
Domain	-	ZNF444 ZNF263 ZNF358 ZNF581 ZKSCAN5 ZNF697	7.56e-03	679	48	6	3.30.160.60
Domain	zf-C2H2	ZNF444 ZNF263 ZNF358 ZNF581 ZKSCAN5 ZNF697	8.32e-03	693	48	6	PF00096
Domain	Znf_C2H2/integrase_DNA-bd	ZNF444 ZNF263 ZNF358 ZNF581 ZKSCAN5 ZNF697	8.38e-03	694	48	6	IPR013087
Domain	UBA-like	USP24 RHBDD3	1.18e-02	64	48	2	IPR009060
Pathway	REACTOME_TFAP2_AP_2_FAMILY_REGULATES_TRANSCRIPTION_OF_CELL_CYCLE_FACTORS	TFAP2A TFAP2C	6.31e-05	5	36	2	M27767
Pathway	REACTOME_NEGATIVE_REGULATION_OF_ACTIVITY_OF_TFAP2_AP_2_FAMILY_TRANSCRIPTION_FACTORS	TFAP2A TFAP2C	2.26e-04	9	36	2	MM15509
Pathway	REACTOME_NEGATIVE_REGULATION_OF_ACTIVITY_OF_TFAP2_AP_2_FAMILY_TRANSCRIPTION_FACTORS	TFAP2A TFAP2C	2.82e-04	10	36	2	M27764
Pathway	REACTOME_ACTIVATION_OF_THE_TFAP2_AP_2_FAMILY_OF_TRANSCRIPTION_FACTORS	TFAP2A TFAP2C	3.44e-04	11	36	2	MM15510
Pathway	REACTOME_ACTIVATION_OF_THE_TFAP2_AP_2_FAMILY_OF_TRANSCRIPTION_FACTORS	TFAP2A TFAP2C	4.12e-04	12	36	2	M27765
Pathway	REACTOME_TFAP2_AP_2_FAMILY_REGULATES_TRANSCRIPTION_OF_GROWTH_FACTORS_AND_THEIR_RECEPTORS	TFAP2A TFAP2C	6.52e-04	15	36	2	M27766
Pathway	REACTOME_SPECIFICATION_OF_THE_NEURAL_PLATE_BORDER	TFAP2A TFAP2C	8.42e-04	17	36	2	M48248
Pubmed	Activator protein-2 impairs the invasion of a human extravillous trophoblast cell line.	TFAP2A TFAP2C	2.03e-06	2	50	2	19443578
Pubmed	Immunohistochemical expression patterns of AP2alpha and AP2gamma in the developing fetal human breast.	TFAP2A TFAP2C	2.03e-06	2	50	2	18042070
Pubmed	Interference with activator protein-2 transcription factors leads to induction of apoptosis and an increase in chemo- and radiation-sensitivity in breast cancer cells.	TFAP2A TFAP2C	2.03e-06	2	50	2	20459791
Pubmed	AP-2.2, a novel gene related to AP-2, is expressed in the forebrain, limbs and face during mouse embryogenesis.	TFAP2A TFAP2C	2.03e-06	2	50	2	8808408
Pubmed	The biological characteristics of transcription factors AP-2α and AP-2γ and their importance in various types of cancers.	TFAP2A TFAP2C	2.03e-06	2	50	2	30824562
Pubmed	AP-2alpha and AP-2gamma regulate tumor progression via specific genetic programs.	TFAP2A TFAP2C	2.03e-06	2	50	2	18443366
Pubmed	A family of AP-2 proteins down-regulate manganese superoxide dismutase expression.	TFAP2A TFAP2C	2.03e-06	2	50	2	11278550
Pubmed	Functional genomics of AP-2α and AP-2γ in cancers: in silico study.	TFAP2A TFAP2C	2.03e-06	2	50	2	33213447
Pubmed	Transcription of cholesterol side-chain cleavage cytochrome P450 in the placenta: activating protein-2 assumes the role of steroidogenic factor-1 by binding to an overlapping promoter element.	TFAP2A TFAP2C	6.07e-06	3	50	2	12145340
Pubmed	A novel alternative spliced variant of the transcription factor AP2alpha is expressed in the murine ocular lens.	TFAP2A TFAP2C	6.07e-06	3	50	2	9758708
Pubmed	Sumoylation pathway is required to maintain the basal breast cancer subtype.	TFAP2A TFAP2C	6.07e-06	3	50	2	24835590
Pubmed	Developmental regulation and overexpression of the transcription factor AP-2, a potential regulator of the timing of Schwann cell generation.	TFAP2A TFAP2C	6.07e-06	3	50	2	11553286
Pubmed	Regulation of Hoxa2 in cranial neural crest cells involves members of the AP-2 family.	TFAP2A TFAP2C	6.07e-06	3	50	2	10068641
Pubmed	Comprehensive analysis of the expression and prognosis for TFAP2 in human lung carcinoma.	TFAP2A TFAP2C	6.07e-06	3	50	2	32462520
Pubmed	AP-2gamma induces p21 expression, arrests cell cycle, and inhibits the tumor growth of human carcinoma cells.	TFAP2A TFAP2C	6.07e-06	3	50	2	16867219
Pubmed	AP-2alpha and AP-2gamma are transcriptional targets of p53 in human breast carcinoma cells.	TFAP2A TFAP2C	6.07e-06	3	50	2	16636674
Pubmed	Tumor suppressor activity of AP2alpha mediated through a direct interaction with p53.	TFAP2A TFAP2C	6.07e-06	3	50	2	12226108
Pubmed	Expression of AP-2α, AP-2γ and ESDN in primary melanomas: correlation with histopathological features and potential prognostic value.	TFAP2A TFAP2C	6.07e-06	3	50	2	23036739
Pubmed	Physical and functional interactions between the Wwox tumor suppressor protein and the AP-2gamma transcription factor.	TFAP2A TFAP2C	6.07e-06	3	50	2	15548692
Pubmed	Chromosomal mapping of the human and mouse homologues of two new members of the AP-2 family of transcription factors.	TFAP2A TFAP2C	6.07e-06	3	50	2	8661133
Pubmed	The DeltaNp63 proteins are key allies of BRCA1 in the prevention of basal-like breast cancer.	TFAP2A TFAP2C	1.21e-05	4	50	2	21363924
Pubmed	The interaction of KCTD1 with transcription factor AP-2alpha inhibits its transactivation.	TFAP2A TFAP2C	1.21e-05	4	50	2	19115315
Pubmed	ACAP3 regulates neurite outgrowth through its GAP activity specific to Arf6 in mouse hippocampal neurons.	ACAP1 ACAP3	1.21e-05	4	50	2	27330119
Pubmed	Transcription factor AP-2gamma regulates murine adenosine deaminase gene expression during placental development.	TFAP2A TFAP2C	1.21e-05	4	50	2	9765260
Pubmed	Regulation of AP-2 and apoptosis in developing eye in a vitamin A-deficiency model.	TFAP2A TFAP2C	1.21e-05	4	50	2	12749383
Pubmed	Cell death or survival promoted by alternative isoforms of ErbB4.	TFAP2A TFAP2C	1.21e-05	4	50	2	20943952
Pubmed	Nephrin regulates lamellipodia formation by assembling a protein complex that includes Ship2, filamin and lamellipodin.	NPHS1 INPPL1	1.21e-05	4	50	2	22194892
Pubmed	Expression of Tfap2d, the gene encoding the transcription factor Ap-2 delta, during mouse embryogenesis.	TFAP2A TFAP2C	1.21e-05	4	50	2	12711551
Pubmed	Segmental expression of the T-box transcription factor, Tbx2, during early somitogenesis.	UNCX TBX2	2.02e-05	5	50	2	16958122
Pubmed	Analysis of transcription factor AP-2 expression and function during mouse preimplantation development.	TFAP2A TFAP2C	2.02e-05	5	50	2	16672719
Pubmed	AP-2α and AP-2β regulate dorsal interneuron specification in the spinal cord.	TFAP2A TFAP2C	2.02e-05	5	50	2	27984181
Pubmed	The human reduced folate carrier gene is regulated by the AP2 and sp1 transcription factor families and a functional 61-base pair polymorphism.	TFAP2A TFAP2C	2.02e-05	5	50	2	12228234
Pubmed	Transcription factor AP-2 interacts with the SUMO-conjugating enzyme UBC9 and is sumolated in vivo.	TFAP2A TFAP2C	2.02e-05	5	50	2	12072434
Pubmed	Critical role of CD81 in cognate T-B cell interactions leading to Th2 responses.	UNCX TBX2	3.03e-05	6	50	2	11978781
Pubmed	Physical and functional interactions among AP-2 transcription factors, p300/CREB-binding protein, and CITED2.	TFAP2A TFAP2C	3.03e-05	6	50	2	12586840
Pubmed	Expression of matrix metalloproteinase (MMP)-2 and MMP-9 in breast cancer with a special reference to activator protein-2, HER2, and prognosis.	TFAP2A TFAP2C	3.03e-05	6	50	2	15569994
Pubmed	Ep400 deficiency in Schwann cells causes persistent expression of early developmental regulators and peripheral neuropathy.	MBP TFAP2A	3.03e-05	6	50	2	31142747
Pubmed	AP-2alpha transcription factor is required for early morphogenesis of the lens vesicle.	TFAP2A TFAP2C	3.03e-05	6	50	2	9918694
Pubmed	Cardiac malformations, adrenal agenesis, neural crest defects and exencephaly in mice lacking Cited2, a new Tfap2 co-activator.	TFAP2A TFAP2C	3.03e-05	6	50	2	11694877
Pubmed	PINK1 expression increases during brain development and stem cell differentiation, and affects the development of GFAP-positive astrocytes.	MBP PINK1	3.03e-05	6	50	2	26746235
Pubmed	Cloning and characterization of the mouse AP-2 epsilon gene: a novel family member expressed in the developing olfactory bulb.	TFAP2A TFAP2C	4.23e-05	7	50	2	14572467
Pubmed	Two regions within the proximal steroidogenic factor 1 promoter drive somatic cell-specific activity in developing gonads of the female mouse.	TFAP2A TFAP2C	4.23e-05	7	50	2	20962249
Pubmed	AP-2ε Expression in Developing Retina: Contributing to the Molecular Diversity of Amacrine Cells.	TFAP2A TFAP2C	4.23e-05	7	50	2	29467543
Pubmed	Integrin receptors are required for cell survival and proliferation during development of the peripheral glial lineage.	TFAP2A TFAP2C	5.64e-05	8	50	2	11319856
Pubmed	Investigating the role of tbx4 in the female germline in mice.	FUT4 TBX2	5.64e-05	8	50	2	24089201
Pubmed	Human CREB-binding protein/p300-interacting transactivator with ED-rich tail (CITED) 4, a new member of the CITED family, functions as a co-activator for transcription factor AP-2.	TFAP2A TFAP2C	5.64e-05	8	50	2	11744733
Pubmed	Smad5 knockout mice die at mid-gestation due to multiple embryonic and extraembryonic defects.	TFAP2A TBX2	7.25e-05	9	50	2	10079226
Pubmed	Cloning of mouse Cited4, a member of the CITED family p300/CBP-binding transcriptional coactivators: induced expression in mammary epithelial cells.	TFAP2A TFAP2C	7.25e-05	9	50	2	12504852
Pubmed	Planar cell polarity pathway regulates actin rearrangement, cell shape, motility, and nephrin distribution in podocytes.	NPHS1 DVL2	7.25e-05	9	50	2	20534871
Pubmed	Single-cell transcriptomics reveals the cellular identity of a novel progenitor population crucial for murine neural tube closure.	TFAP2A TFAP2C	9.05e-05	10	50	2	39296075
Pubmed	Cited2 controls left-right patterning and heart development through a Nodal-Pitx2c pathway.	TFAP2A TFAP2C	1.10e-04	11	50	2	15475956
Pubmed	Pdgfrα functions in endothelial-derived cells to regulate neural crest cells and the development of the great arteries.	HSPG2 TFAP2A	1.10e-04	11	50	2	28714851
Pubmed	Novel role for Netrins in regulating epithelial behavior during lung branching morphogenesis.	UNC5A HSPG2	1.10e-04	11	50	2	15186747
Pubmed	Periostin as a biomarker of the amniotic membrane.	TFAP2A TBX2	1.10e-04	11	50	2	22966238
Pubmed	Impact of cytosine methylation on DNA binding specificities of human transcription factors.	ZNF444 ZNF263 UNCX TFAP2A TFAP2C TBX2	1.26e-04	544	50	6	28473536
Pubmed	Dishevelled 2 is essential for cardiac outflow tract development, somite segmentation and neural tube closure.	UNCX DVL2	1.32e-04	12	50	2	12421720
Pubmed	Activating enhancer binding protein 2 epsilon (AP-2ε)-deficient mice exhibit increased matrix metalloproteinase 13 expression and progressive osteoarthritis development.	TFAP2A TFAP2C	1.32e-04	12	50	2	25964075
Pubmed	The functional interactome of PYHIN immune regulators reveals IFIX is a sensor of viral DNA.	HSPG2 ZNF444 TSR1 TFAP2A TFAP2C	1.45e-04	349	50	5	25665578
Pubmed	The mitochondrial protease HtrA2 is regulated by Parkinson's disease-associated kinase PINK1.	MBP PINK1	1.56e-04	13	50	2	17906618
Pubmed	Conditional deletion of activating protein 2alpha (AP-2alpha) in the developing retina demonstrates non-cell-autonomous roles for AP-2alpha in optic cup development.	TFAP2A TFAP2C	1.56e-04	13	50	2	17724084
Pubmed	Deficiency of the planar cell polarity protein Vangl2 in podocytes affects glomerular morphogenesis and increases susceptibility to injury.	NPHS1 DVL2	1.82e-04	14	50	2	25145929
Pubmed	Hoxa1 lineage tracing indicates a direct role for Hoxa1 in the development of the inner ear, the heart, and the third rhombomere.	MBP TFAP2A	1.82e-04	14	50	2	20171203
Pubmed	AP-2α and AP-2β cooperatively function in the craniofacial surface ectoderm to regulate chromatin and gene expression dynamics during facial development.	DVL2 TFAP2A	2.10e-04	15	50	2	35333176
Pubmed	Sox9 overexpression exerts multiple stage-dependent effects on mouse spinal cord development.	MBP TFAP2A	2.10e-04	15	50	2	31724774
Pubmed	Disrupting hedgehog and WNT signaling interactions promotes cleft lip pathogenesis.	FUT4 TFAP2A	2.10e-04	15	50	2	24590292
Pubmed	IRF6 and AP2A Interaction Regulates Epidermal Development.	TFAP2A TFAP2C	2.40e-04	16	50	2	29913133
Pubmed	Nucleoredoxin sustains Wnt/β-catenin signaling by retaining a pool of inactive dishevelled protein.	HSPG2 DVL2	2.72e-04	17	50	2	20970343
Pubmed	TMEM132A ensures mouse caudal neural tube closure and regulates integrin-based mesodermal migration.	UNCX TMEM132A	2.72e-04	17	50	2	35950911
Pubmed	Identification of a Tbx1/Tbx2/Tbx3 genetic pathway governing pharyngeal and arterial pole morphogenesis.	TFAP2A TBX2	3.05e-04	18	50	2	22116936
Pubmed	Smad5 determines murine amnion fate through the control of bone morphogenetic protein expression and signalling levels.	FUT4 TFAP2A	3.05e-04	18	50	2	16887830
Pubmed	Gestational folate deficiency alters embryonic gene expression and cell function.	TFAP2A TBX2	3.05e-04	18	50	2	33302058
Pubmed	Posterior malformations in Dact1 mutant mice arise through misregulated Vangl2 at the primitive streak.	UNCX DVL2	3.05e-04	18	50	2	19701191
Pubmed	A critical function of Mad2l2 in primordial germ cell development of mice.	FUT4 TFAP2C	3.41e-04	19	50	2	24009519
Pubmed	SHROOM3 is downstream of the planar cell polarity pathway and loss-of-function results in congenital heart defects.	DVL2 TFAP2A	3.79e-04	20	50	2	32511952
Pubmed	β-catenin regulates Pax3 and Cdx2 for caudal neural tube closure and elongation.	UNCX DVL2	4.18e-04	21	50	2	24284205
Pubmed	Prdm13 regulates subtype specification of retinal amacrine interneurons and modulates visual sensitivity.	TFAP2A TFAP2C	4.18e-04	21	50	2	25995483
Pubmed	FGFR1 function at the earliest stages of mouse limb development plays an indispensable role in subsequent autopod morphogenesis.	TFAP2A TBX2	4.18e-04	21	50	2	16207751
Pubmed	AP-2 factors act in concert with Notch to orchestrate terminal differentiation in skin epidermis.	TFAP2A TFAP2C	4.18e-04	21	50	2	18824566
Pubmed	Trans-differentiation of outer hair cells into inner hair cells in the absence of INSM1.	PINK1 TBX2	4.59e-04	22	50	2	30305733
Pubmed	CNKSR1 serves as a scaffold to activate an EGFR phosphatase via exclusive interaction with RhoB-GTP.	PPFIA1 ZKSCAN5	4.59e-04	22	50	2	34187934
Pubmed	Functional genetic analysis of mouse chromosome 11.	RPL27A ACAP1	5.03e-04	23	50	2	12955145
Pubmed	Transcriptome analysis for Notch3 target genes identifies Grip2 as a novel regulator of myogenic response in the cerebrovasculature.	XIRP1 TBX2	5.03e-04	23	50	2	23117660
Pubmed	Tbx3 is required for outflow tract development.	TFAP2A TBX2	5.48e-04	24	50	2	18723448
Pubmed	Conditional deletion of beta1-integrin in astroglia causes partial reactive gliosis.	HSPG2 MBP	5.95e-04	25	50	2	19373938
Pubmed	Overlapping expression patterns and redundant roles for AP-2 transcription factors in the developing mammalian retina.	TFAP2A TFAP2C	5.95e-04	25	50	2	22411557
Pubmed	AP2gamma regulates basal progenitor fate in a region- and layer-specific manner in the developing cortex.	TFAP2A TFAP2C	6.44e-04	26	50	2	19749747
Pubmed	A Grhl2-dependent gene network controls trophoblast branching morphogenesis.	TFAP2A TFAP2C	6.95e-04	27	50	2	25758223
Pubmed	Critical role of phosphodiesterase 2A in mouse congenital heart defects.	TFAP2A TBX2	7.48e-04	28	50	2	29409032
Pubmed	Single-cell transcriptomic landscapes of the otic neuronal lineage at multiple early embryonic ages.	MYT1 TBX2	8.59e-04	30	50	2	35320729
Pubmed	R-spondin signalling is essential for the maintenance and differentiation of mouse nephron progenitors.	NPHS1 UNCX	8.59e-04	30	50	2	32324134
Pubmed	Placing the HIRA histone chaperone complex in the chromatin landscape.	TFAP2A TFAP2C	9.17e-04	31	50	2	23602572
Pubmed	ΔNp63 knockout mice reveal its indispensable role as a master regulator of epithelial development and differentiation.	HSPG2 TFAP2A	9.17e-04	31	50	2	22274697
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	SASH1 TSR1 TEX2 L3MBTL3 ACAP3	9.63e-04	529	50	5	14621295
Pubmed	Fate Specification of Neural Plate Border by Canonical Wnt Signaling and Grhl3 is Crucial for Neural Tube Closure.	TFAP2A TFAP2C	1.10e-03	34	50	2	26288816
Pubmed	Large-scale identification of genes implicated in kidney glomerulus development and function.	NPHS1 HSPG2	1.10e-03	34	50	2	16498405
Pubmed	A complex oscillating network of signaling genes underlies the mouse segmentation clock.	HSPG2 UNCX	1.31e-03	37	50	2	17095659
GeneFamily	Sterile alpha motif domain containing	SASH1 INPPL1 PPFIA1 L3MBTL3	2.74e-05	88	36	4	760
GeneFamily	X-linked mental retardation\|Rho GTPase activating proteins\|BAR-PH domain containing	ACAP1 ACAP3	5.14e-04	17	36	2	1291
GeneFamily	ArfGAPs	ACAP1 ACAP3	1.96e-03	33	36	2	395
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF444 ZNF263 ZNF358 ZNF581 ZKSCAN5 ZNF697	2.70e-03	718	36	6	28
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	ACAP1 PLEKHG6 ACAP3	7.89e-03	206	36	3	682
Coexpression	GSE3982_BCELL_VS_CENT_MEMORY_CD4_TCELL_DN	NPHS1 TTLL3 SASH1 MBP GPR37L1 ATP10A	2.08e-06	198	50	6	M5545
ToppCell	390C-Myeloid-Macrophage-SPP1+_Macrophage_4\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	TRIM72 SASH1 PLEKHG6 CCDC51	4.05e-05	171	50	4	7c8304573b892ef9ea4e048cba9ea9fbab848dcd
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-24m-Mesenchymal-brain_pericyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CCDC51 L3MBTL3 ZKSCAN5 TBX2	4.84e-05	179	50	4	f99500c4a590e5152ded5862690f7fa614d64a80
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-24m-Mesenchymal-Pericyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CCDC51 L3MBTL3 ZKSCAN5 TBX2	4.84e-05	179	50	4	7d61466181ab73088de3ec8a129d7cfa8cac7ecc
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-24m-Mesenchymal\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CCDC51 L3MBTL3 ZKSCAN5 TBX2	4.84e-05	179	50	4	6c98ce32cb55cf9cee557449e41b23bdb22f5efd
ToppCell	droplet-Kidney-nan-21m-Epithelial-Epcam____kidney_collecting_duct_principal_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TMEM151B TMEM132A TFAP2A TBX2	5.16e-05	182	50	4	fe4fb213dc0ca482b0f94097fe1b0a51fc2690e2
ToppCell	wk_20-22-Epithelial-PNS-intermediate_Schwann\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	HSPG2 ZNF358 MBP TMEM132A	5.38e-05	184	50	4	4e3ba64692868563a579902aa9c6f88cab5bce26
ToppCell	5'-GW_trimst-2-LargeIntestine-Neuronal-Glial_immature-Glia_1_(DHH+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	HSPG2 MBP GPR37L1 TFAP2A	5.61e-05	186	50	4	6f88b68735d0f7c9904eb8413e6007910d556185
ToppCell	droplet-Heart-HEART_(ALL_4:4:4:1:1)-30m-Neuronal-nan\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PLEKHG6 MBP FUT4 ZNF697	5.73e-05	187	50	4	5fae538de481367cf6d9a2d52190d77b99f6922c
ToppCell	droplet-Heart-HEART_(ALL_4:4:4:1:1)-30m-Neuronal-cardiac_neuron\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PLEKHG6 MBP FUT4 ZNF697	5.73e-05	187	50	4	22fd1959879705a8c1128faa9de66696c4e0b7e3
ToppCell	droplet-Heart-HEART_(ALL_4:4:4:1:1)-30m-Neuronal\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PLEKHG6 MBP FUT4 ZNF697	5.73e-05	187	50	4	0526c0a818cf28fd5b6ff65fe260e3c3a4a98a2a
ToppCell	3'-GW_trimst-1-LargeIntestine-Neuronal-neuron_precursor-cycling_neuroblast\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	UNC5A MYT1 TFAP2A TBX2	5.97e-05	189	50	4	815afad947ed77a8b03724bf78014799fed34f54
ToppCell	5'-GW_trimst-2-SmallIntestine-Neuronal-neuron_precursor-Neuroblast\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MYT1 TMEM151B TFAP2A TBX2	6.22e-05	191	50	4	c7b95a5f9185d533c08754ce2e4ce91533eb612e
ToppCell	3'-GW_trimst-1-LargeIntestine-Neuronal-neuron_precursor\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MYT1 TFAP2A ACAP3 TBX2	6.22e-05	191	50	4	a53616c84178eb6c29b48662358765b082df3f97
ToppCell	5'-GW_trimst-2-SmallIntestine-Neuronal-neuron_precursor\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MYT1 TMEM151B TFAP2A TBX2	6.35e-05	192	50	4	56f2388c9c4e19883ae5cff332c77f596ff744a8
ToppCell	5'-GW_trimst-2-SmallIntestine-Neuronal-Glial_immature-Glia_1_(DHH+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	HSPG2 MBP GPR37L1 TFAP2A	6.88e-05	196	50	4	e6adcfe1a00d4910e0b92848f8a80224e0d6db12
ToppCell	3'-GW_trimst-1-SmallIntestine-Neuronal-neuron_precursor\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MYT1 TFAP2A ACAP3 TBX2	7.01e-05	197	50	4	1378bf90a4b80b8166ef352c282ce51b114ba693
ToppCell	3'-GW_trimst-1-LargeIntestine-Neuronal-neurons_A-Branch_A1_(iMN)\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MYT1 TMEM151B ACAP3 TBX2	7.01e-05	197	50	4	fd43fc1cbf0c17b370397d73dddc572565a759c7
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-1M-Neuronal-midbrain/hindbrain_cells\|Organoid-1M / Sample Type, Dataset, Time_group, and Cell type.	MYT1 TFAP2A PLPPR2 ACAP3	7.01e-05	197	50	4	c7078f6fcf27319ba8c5ebe700bcae7f1e7e39c1
ToppCell	3'-GW_trimst-1-SmallIntestine-Neuronal-neuron_precursor-Neuroblast\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MYT1 TFAP2A ACAP3 TBX2	7.15e-05	198	50	4	c506334d81af672ef9ddc8c4fd2a790bdb58e63e
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-3m-OPC_related-Oligodendrocyte/OPC\|3m / Sample Type, Dataset, Time_group, and Cell type.	RPL27A INPPL1 MYT1 TFAP2C	7.44e-05	200	50	4	7557ea33c3d080d0fa4ca0c2703279932d01e6d0
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-3m-OPC_related\|3m / Sample Type, Dataset, Time_group, and Cell type.	RPL27A INPPL1 MYT1 TFAP2C	7.44e-05	200	50	4	3dcaeb9f1e387784c299bfe0da1516598f82edf5
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-6m-Neuronal-Neuron\|6m / Sample Type, Dataset, Time_group, and Cell type.	UNC5A UNCX MYT1 ACAP3	7.44e-05	200	50	4	b5019b9d48f32cffd4645a5c0f3e0ac504ea8019
Drug	STOCK1N-35215; Down 200; 10uM; PC3; HT_HG-U133A	MEGF8 DVL2 ATP10A TFAP2C TBX2	6.62e-05	194	50	5	6380_DN
Drug	Cephalosporanic acid, 7-amino [957-68-6]; Down 200; 14.6uM; PC3; HT_HG-U133A	HSPG2 ZNF444 ZNF358 FUT4 TFAP2A	6.62e-05	194	50	5	4242_DN
Drug	genistein; Down 200; 1uM; MCF7; HG-U133A	RNFT2 MYT1 MBP ATP10A PLPPR2	6.78e-05	195	50	5	268_DN
Drug	3-alpha-Hydroxy-5-beta-androstan-17-one [53-42-9]; Down 200; 13.8uM; HL60; HT_HG-U133A	MEGF8 MYT1 DVL2 ZKSCAN5 PINK1	7.12e-05	197	50	5	2204_DN
Drug	Moxonidine [75438-57-2]; Down 200; 16.6uM; PC3; HT_HG-U133A	INPPL1 MYT1 DVL2 FUT4 TFAP2C	7.12e-05	197	50	5	4084_DN
Drug	Fluorometholone [426-13-1]; Down 200; 10.6uM; PC3; HT_HG-U133A	ZNF444 RNFT2 ZKSCAN5 PLPPR2 TFAP2C	7.12e-05	197	50	5	5771_DN
Drug	Mephenytoin [50-12-4]; Down 200; 18.4uM; PC3; HT_HG-U133A	ZNF444 ZNF358 TMEM132A TFAP2C TBX2	7.12e-05	197	50	5	5801_DN
Drug	Idoxuridine [54-42-2]; Down 200; 11.2uM; MCF7; HT_HG-U133A	ZNF444 GPAA1 SASH1 PLEKHG6 RHBDD3	7.29e-05	198	50	5	4785_DN
Drug	Diperodon hydrochloride [537-12-2]; Down 200; 9.2uM; PC3; HT_HG-U133A	PLEKHG6 RNFT2 INPPL1 DVL2 FUT4	7.29e-05	198	50	5	4498_DN
Drug	Lactobionic acid [96-82-2]; Down 200; 11.2uM; MCF7; HT_HG-U133A	GPAA1 SH2D3A DVL2 RHBDD3 PLPPR2	7.29e-05	198	50	5	3246_DN
Drug	PHA-00851261E [724719-49-7]; Down 200; 10uM; MCF7; HT_HG-U133A	HSPG2 ZNF444 SASH1 ZNF358 PLPPR2	7.29e-05	198	50	5	3854_DN
Drug	2-Aminobenzenesulfonamide [3306-62-5]; Down 200; 23.2uM; MCF7; HT_HG-U133A	ZNF444 ACAP1 SH2D3A RHBDD3 PLPPR2	7.29e-05	198	50	5	5422_DN
Drug	Merbromin [129-16-8]; Up 200; 5uM; PC3; HT_HG-U133A	ZNF444 ACAP1 ZNF358 ATP10A ZKSCAN5	7.29e-05	198	50	5	7398_UP
Drug	(R)-(+)-Atenolol [56715-13-0]; Down 200; 15uM; MCF7; HT_HG-U133A	HSPG2 SASH1 SH2D3A FUT4 PLPPR2	7.47e-05	199	50	5	2855_DN
Drug	Spectinomycin dihydrochloride [21736-83-4]; Down 200; 9.8uM; HL60; HT_HG-U133A	HSPG2 ACAP1 DVL2 RHBDD3 TFAP2A	7.47e-05	199	50	5	2987_DN
Drug	5707885; Down 200; 50uM; MCF7; HT_HG-U133A	ZNF444 MEGF8 ZNF358 FUT4 PLPPR2	7.47e-05	199	50	5	6433_DN
Drug	Acenocoumarol [152-72-7]; Up 200; 11.4uM; PC3; HT_HG-U133A	HSPG2 ZNF444 ZNF358 TMEM132A GPR37L1	7.65e-05	200	50	5	2077_UP
Drug	Cefotetan [69712-56-7]; Down 200; 7uM; PC3; HT_HG-U133A	HSPG2 PLEKHG6 PPFIA1 RHBDD3 PLPPR2	7.65e-05	200	50	5	3997_DN
Drug	Isotretinoin [4759-48-2]; Down 200; 13.4uM; PC3; HT_HG-U133A	ZNF358 RHBDD3 ZKSCAN5 TFAP2C TBX2	7.65e-05	200	50	5	7315_DN
Disease	dextro-looped transposition of the great arteries (implicated_via_orthology)	HSPG2 DVL2	1.55e-05	4	48	2	DOID:0060770 (implicated_via_orthology)
Disease	sleep disorder (implicated_via_orthology)	TFAP2A TFAP2C	1.41e-04	11	48	2	DOID:535 (implicated_via_orthology)
Disease	cytotoxicity measurement, response to clozapine	MYT1 PLPPR2	1.02e-03	29	48	2	EFO_0006952, GO_0097338
Disease	hippocampal CA4 volume	RNFT2 TMEM132A	2.04e-03	41	48	2	EFO_0009396
Disease	Neuroblastoma	PINK1 TBX2	2.67e-03	47	48	2	C0027819
Disease	restless legs syndrome	UNCX MYT1	2.90e-03	49	48	2	EFO_0004270

Protein segments in the cluster

Peptide	Gene	Start	Entry
SHHGRPAGLLPHLSG	TFAP2C	116	Q92754
GLLHTHRGLPHQLSG	TFAP2A	106	P05549
GRAPLHHATLLGRTG	ACAP3	736	Q96P50
RGPLHHATILGHTGL	ACAP1	641	Q15027
GHRTGGPSRLERHLA	DVL2	176	O14641
HSGRSGLQGPDHRLL	ATP10A	1476	O60312
GHGATAPHRSLLAIH	NFE4	76	Q86UQ8
HKRGGSLPARHQTHG	HSPG2	2186	P98160
HKRGGSLPARHQVHG	HSPG2	2471	P98160
RGGSLPSRHQTHGSH	HSPG2	2666	P98160
IGHFKRARHLGPHSA	L3MBTL3	566	Q96JM7
AGGPRHRILSSGALH	NPHS1	691	O60500
ASGCSHRHRGRFPLH	MAP10	151	Q9P2G4
RQASGRPHGSHGLFL	GPAA1	296	O43292
HLALAARPARHLGGA	FUT4	56	P22083
SRLHPEGLGHGRTLF	PINK1	301	Q9BXM7
HSPSRGRHGSGLGHS	HRNR	1241	Q86YZ3
FHAPSRALLVHGGHR	MEGF8	396	Q7Z7M0
LRGASLHHGRPHLGS	PPFIA1	516	Q13136
AGRIRHRHGSPHPSR	PLPPR2	321	Q96GM1
KRHGGHVGAGLLHSP	PLEKHG6	81	Q3KR16
VLQGHHTRLHGSPGH	FCSK	421	Q8N0W3
PVLREGLGSLHTRHH	CSF2RB	291	P32927
RVSGGAPLHLGRHRA	GPR37L1	21	O60883
DHARHGFLPRHRDTG	MBP	156	P02686
SGAGGCSLSHHRPRL	LCE2C	66	Q5TA81
LRGHVSHGHGRIGKH	RPL27A	11	P46776
HRGGSLLQHVGGDHR	RNFT2	121	Q96EX2
AHPLDGGRRLTHLLG	TMEM132A	556	Q24JP5
GCLGHSHRPLHRHGS	TMEM151B	546	Q8IW70
LHHRLPALGRALGHS	CCDC51	56	Q96ER9
LGHHRHPRVGEGSSS	INPPL1	1026	O15357
HRLLTHALGHTALPG	RHBDD3	51	Q9Y3P4
HLRRHRDTHPGSPGS	ZNF444	221	Q8N0Y2
GRRGHIKEPLGTHGH	TSR1	736	Q2NL82
GAGHLPGLAFSSHLH	TBX2	461	Q13207
RGLFLEHHPGSTALH	SH2D3A	306	Q9BRG2
SGLELLTLPHGHHLR	SH2D3A	346	Q9BRG2
PPSGHSTRHRTLHGL	nan	6	Q6ZSV7
HGLARTPLEGHRKGH	SASH1	941	O94885
LGSHRGHRLLPAAEA	TRIM72	111	Q6ZMU5
RGSGEARHHFPSLHT	TTLL3	561	Q9Y4R7
SPLGGGRHTLHHSSP	UNC5A	401	Q6ZN44
HLSLGSRHRGDKPAH	ZNF697	146	Q5TEC3
TVHPRGLHRGAGARL	TPRN	206	Q4KMQ1
RTILPHGASFHGHLL	USP24	946	Q9UPU5
ARHHSIHLAGGGRPH	ZNF581	131	Q9P0T4
GLLPAHSRHNSPSGH	TEX2	726	Q8IWB9
RTLHATPGILHHGGI	XIRP1	776	Q702N8
GFGRRSHLAGHLRLH	ZKSCAN5	641	Q9Y2L8
GRHLHSPGGLSLHSA	UNCX	216	A6NJT0
HGSLLAQHLRTHGGP	ZNF358	246	Q9NW07
GGNPRFLSLHRAHLG	ZNF263	416	O14978
GHVTGLYPHHRSLSG	MYT1	451	Q01538