Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctioninositol 1,4,5-trisphosphate-gated calcium channel activity

ITPR2 ITPR3

4.05e-053742GO:0005220
GeneOntologyMolecularFunctionintracellularly ligand-gated monoatomic ion channel activity

HCN4 ITPR2 ITPR3

2.46e-0433743GO:0005217
DomainInsP3_rcpt-bd

ITPR2 ITPR3

4.76e-053752IPR000493
DomainRIH_assoc

ITPR2 ITPR3

2.36e-046752PF08454
DomainRIH_assoc-dom

ITPR2 ITPR3

2.36e-046752IPR013662
DomainRIH_dom

ITPR2 ITPR3

2.36e-046752IPR000699
DomainIns145_P3_rcpt

ITPR2 ITPR3

2.36e-046752IPR014821
DomainRyanodine_recept-rel

ITPR2 ITPR3

2.36e-046752IPR015925
DomainXpo1

XPO5 XPO1

2.36e-046752PF08389
Domain-

ITPR2 ITPR3

2.36e-0467521.25.10.30
DomainRYDR_ITPR

ITPR2 ITPR3

2.36e-046752PF01365
DomainIns145_P3_rec

ITPR2 ITPR3

2.36e-046752PF08709
DomainExportin-1/Importin-b-like

XPO5 XPO1

2.36e-046752IPR013598
DomainMIR

ITPR2 ITPR3

7.01e-0410752PS50919
DomainMIR

ITPR2 ITPR3

7.01e-0410752PF02815
DomainMIR

ITPR2 ITPR3

7.01e-0410752SM00472
DomainMIR_motif

ITPR2 ITPR3

7.01e-0410752IPR016093
DomainIBN_N

XPO5 XPO1

1.84e-0316752SM00913
DomainImportin-beta_N

XPO5 XPO1

2.08e-0317752IPR001494
DomainDSRM

DROSHA STAU2

2.60e-0319752SM00358
Domaindsrm

DROSHA STAU2

2.88e-0320752PF00035
DomainDS_RBD

DROSHA STAU2

3.18e-0321752PS50137
DomainSEA

MUC12 MUC3A

3.81e-0323752PS50024
DomainSEA_dom

MUC12 MUC3A

3.81e-0323752IPR000082
Domain-

DROSHA STAU2

5.23e-03277523.30.160.20
DomaindsRBD_dom

DROSHA STAU2

5.62e-0328752IPR014720
DomainCNMP_BINDING_1

CNBD1 HCN4

7.30e-0332752PS00888
DomainCNMP_BINDING_2

CNBD1 HCN4

7.30e-0332752PS00889
DomaincNMP_binding

CNBD1 HCN4

8.21e-0334752PF00027
PathwayKEGG_MEDICUS_VARIANT_MUTATION_INACTIVATED_PRKN_TO_MGLUR1_SIGNALING_PATHWAY

ITPR2 ITPR3

1.08e-045472M49000
PathwayWP_EXRNA_MECHANISM_OF_ACTION_AND_BIOGENESIS

XPO5 DROSHA

1.62e-046472M39578
PathwayWP_MIRNA_BIOGENESIS

XPO5 DROSHA

1.62e-046472M39416
PathwayKEGG_MEDICUS_REFERENCE_CA2_PLCD_ITPR_SIGNALING_PATHWAY

ITPR2 ITPR3

1.62e-046472M47960
PathwayKEGG_MEDICUS_REFERENCE_BCR_PLCG_ITPR_SIGNALING_PATHWAY

ITPR2 ITPR3

3.86e-049472M47852
PathwayWP_RENINANGIOTENSINALDOSTERONE_SYSTEM_RAAS

CREB3L2 ITPR2 ITPR3

4.18e-0444473M39845
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_SPTBN2_TO_MGLUR1_TRPC3_SIGNALING_PATHWAY

ITPR2 ITPR3

4.81e-0410472M47661
PathwayKEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_PRKCG_TO_MGLUR1_TRPC3_SIGNALING_PATHWAY

ITPR2 ITPR3

5.87e-0411472M49033
PathwayREACTOME_CLEC7A_DECTIN_1_INDUCES_NFAT_ACTIVATION

ITPR2 ITPR3

5.87e-0411472M27466
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_PSEN1_TO_MGLUR5_CA2_APOPTOTIC_PATHWAY

ITPR2 ITPR3

8.29e-0413472M47696
PathwayKEGG_MEDICUS_VARIANT_MUTATION_INACTIVATED_SIGMAR1_TO_CA2_APOPTOTIC_PATHWAY

ITPR2 ITPR3

8.29e-0413472M47751
PathwayKEGG_MEDICUS_REFERENCE_MGLUR1_TRPC3_SIGNALING_PATHWAY

ITPR2 ITPR3

8.29e-0413472M47656
PathwayREACTOME_ELEVATION_OF_CYTOSOLIC_CA2_LEVELS

ITPR2 ITPR3

8.29e-0413472MM14553
PathwayREACTOME_C_TYPE_LECTIN_RECEPTORS_CLRS

MUC12 MUC3A ITPR2 ITPR3

1.19e-03140474M27484
PathwayREACTOME_DEFECTIVE_GALNT3_CAUSES_HFTC

MUC12 MUC3A

1.27e-0316472M27410
PathwayREACTOME_ELEVATION_OF_CYTOSOLIC_CA2_LEVELS

ITPR2 ITPR3

1.27e-0316472M26945
PathwayREACTOME_DEFECTIVE_C1GALT1C1_CAUSES_TNPS

MUC12 MUC3A

1.43e-0317472M27412
Pubmed

LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.

XPO5 RPN2 PRRC2C ANKRD17 CRYBG1 XPO1 CDC42BPB ITPR3

1.52e-0820276833005030
Pubmed

Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.

XPO5 CENPF RPN2 PRRC2C PHRF1 DDX42 ANKRD17 XPO1 ANKHD1 UTRN ITPR3

1.78e-07653761122586326
Pubmed

Human Immunodeficiency Virus Type 1 Vpr Mediates Degradation of APC1, a Scaffolding Component of the Anaphase-Promoting Complex/Cyclosome.

SMG7 DROSHA PRRC2C ANKRD17 LRRC40 MCCC1 ANKHD1

1.05e-0624276734011540
Pubmed

Virus-Host Interactome and Proteomic Survey Reveal Potential Virulence Factors Influencing SARS-CoV-2 Pathogenesis.

XPO5 RPN2 XPO1 ANKHD1 ITPR2 ITPR3 NIN

3.11e-0628576732838362
Pubmed

Isoform diversity of the inositol trisphosphate receptor in cell types of mouse origin.

ITPR2 ITPR3

4.71e-0627629065779
Pubmed

Expression of IP3 receptor isoforms at the nodes of Ranvier in rat sciatic nerve.

ITPR2 ITPR3

4.71e-06276217496801
Pubmed

Mice lacking inositol 1,4,5-trisphosphate receptors exhibit dry eye.

ITPR2 ITPR3

4.71e-06276224901844
Pubmed

Adrenergic inhibition facilitates normalization of extracellular potassium after cortical spreading depolarization.

ITPR2 ITPR3

4.71e-06276233854148
Pubmed

Pancreatic protease activation by alcohol metabolite depends on Ca2+ release via acid store IP3 receptors.

ITPR2 ITPR3

4.71e-06276219528657
Pubmed

Determination of relative amounts of inositol trisphosphate receptor mRNA isoforms by ratio polymerase chain reaction.

ITPR2 ITPR3

4.71e-0627628063813
Pubmed

Cloning and characterization of human type 2 and type 3 inositol 1,4,5-trisphosphate receptors.

ITPR2 ITPR3

4.71e-0627628081734
Pubmed

IP3 receptor types 2 and 3 mediate exocrine secretion underlying energy metabolism.

ITPR2 ITPR3

4.71e-06276216195467
Pubmed

Molecular cloning of mouse type 2 and type 3 inositol 1,4,5-trisphosphate receptors and identification of a novel type 2 receptor splice variant.

ITPR2 ITPR3

4.71e-06276215632133
Pubmed

Inositol (1,4,5)-trisphosphate receptor links to filamentous actin are important for generating local Ca2+ signals in pancreatic acinar cells.

ITPR2 ITPR3

4.71e-06276215713744
Pubmed

Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.

PIKFYVE SMG7 DROSHA PRRC2C N4BP2 SASS6 MCCC1 ZCCHC2 NIN

5.53e-0658876938580884
Pubmed

A human MAP kinase interactome.

N4BP2 ANKRD17 BICRAL MUC12 ZNF839 CDC42BPB FBXO30 MADD

1.13e-0548676820936779
Pubmed

Human transcription factor protein interaction networks.

TCF3 SMG7 RPN2 PRRC2C KLF5 STAU2 ANKRD17 SP9 RPRD2 PROSER1 MCCC1 ANKHD1 TFDP2

1.23e-051429761335140242
Pubmed

Rescue of calcineurin Aα(-/-) mice reveals a novel role for the α isoform in the salivary gland.

ITPR2 ITPR3

1.41e-05376221435446
Pubmed

Evidence that type I, II, and III inositol 1,4,5-trisphosphate receptors can occur as integral plasma membrane proteins.

ITPR2 ITPR3

1.41e-05376210874040
Pubmed

Expression of inositol 1,4,5-trisphosphate receptors in mouse oocytes and early embryos: the type I isoform is upregulated in oocytes and downregulated after fertilization.

ITPR2 ITPR3

1.41e-0537629808793
Pubmed

Abnormal distribution of inositol 1,4,5-trisphosphate receptors in human muscle can be related to altered calcium signals and gene expression in Duchenne dystrophy-derived cells.

ITPR2 ITPR3

1.41e-05376220395455
Pubmed

Association between Genetic Polymorphisms in microRNA Machinery Genes and Risk of Papillary Thyroid Carcinoma.

XPO5 DROSHA

1.41e-05376231250375
Pubmed

Inositol 1,4,5-trisphosphate receptors are autoantibody target antigens in patients with Sjögren's syndrome and other systemic rheumatic diseases.

ITPR2 ITPR3

1.41e-05376217437169
Pubmed

Type 2 and type 3 inositol 1,4,5-trisphosphate (IP3) receptors promote the differentiation of granule cell precursors in the postnatal cerebellum.

ITPR2 ITPR3

1.41e-05376218194433
Pubmed

Re-evaluation of the roles of DROSHA, Export in 5, and DICER in microRNA biogenesis.

XPO5 DROSHA

1.41e-05376226976605
Pubmed

Decreased olfactory mucus secretion and nasal abnormality in mice lacking type 2 and type 3 IP3 receptors.

ITPR2 ITPR3

1.41e-05376218547250
Pubmed

Inositol 1,4,5-trisphosphate receptor gene variants are related to the risk of breast cancer in a Chinese population.

ITPR2 ITPR3

1.41e-05376236350267
Pubmed

IP3 receptors regulate vascular smooth muscle contractility and hypertension.

ITPR2 ITPR3

1.41e-05376227777977
Pubmed

The versatility and universality of calcium signalling.

ITPR2 ITPR3

1.41e-05376211413485
Pubmed

Using concatenated subunits to investigate the functional consequences of heterotetrameric inositol 1,4,5-trisphosphate receptors.

ITPR2 ITPR3

1.41e-05376226009177
Pubmed

Differential inositol 1,4,5-trisphosphate receptor signaling in a neuronal cell line.

ITPR2 ITPR3

1.41e-05376217581770
Pubmed

Predominant role of type 1 IP3 receptor in aortic vascular muscle contraction.

ITPR2 ITPR3

1.41e-05376218241669
Pubmed

Receptor-activated single channels in intact human platelets.

ITPR2 ITPR3

1.41e-0537621693919
Pubmed

Granulosa cells express three inositol 1,4,5-trisphosphate receptor isoforms: cytoplasmic and nuclear Ca2+ mobilization.

ITPR2 ITPR3

1.41e-05376219068129
Pubmed

Functional inositol 1,4,5-trisphosphate receptors assembled from concatenated homo- and heteromeric subunits.

ITPR2 ITPR3

1.41e-05376223955339
Pubmed

Type 3 Inositol 1,4,5-Trisphosphate Receptor is a Crucial Regulator of Calcium Dynamics Mediated by Endoplasmic Reticulum in HEK Cells.

ITPR2 ITPR3

1.41e-05376231979185
Pubmed

Tsg101 regulates PI(4,5)P2/Ca(2+) signaling for HIV-1 Gag assembly.

ITPR2 ITPR3

1.41e-05376224904548
Pubmed

Molecular basis of the isoform-specific ligand-binding affinity of inositol 1,4,5-trisphosphate receptors.

ITPR2 ITPR3

1.41e-05376217327232
Pubmed

Inducing cell proliferation inhibition and apoptosis via silencing Dicer, Drosha, and Exportin 5 in urothelial carcinoma of the bladder.

XPO5 DROSHA

1.41e-05376222766726
Pubmed

Nuclear inositol 1,4,5-trisphosphate receptors regulate local Ca2+ transients and modulate cAMP response element binding protein phosphorylation.

ITPR2 ITPR3

1.41e-05376216014380
Pubmed

The impact of Dicer, Drosha, and Exportin-5 levels in polycystic ovary syndrome (PCOS) diagnosis and phenotyping.

XPO5 DROSHA

1.41e-05376234855193
Pubmed

Mask family proteins ANKHD1 and ANKRD17 regulate YAP nuclear import and stability.

ANKRD17 ANKHD1

1.41e-05376231661072
Pubmed

Knockdown of the type 2 and 3 inositol 1,4,5-trisphosphate receptors suppresses muscarinic antinociception in mice.

ITPR2 ITPR3

1.41e-05376217890015
Pubmed

Inositol 1, 4, 5-trisphosphate receptors and human left ventricular myocytes.

ITPR2 ITPR3

1.41e-05376223983250
Pubmed

Differential distribution of inositol trisphosphate receptor isoforms in mouse oocytes.

ITPR2 ITPR3

1.41e-0537629858485
Pubmed

Activation of the inositol (1,4,5)-triphosphate calcium gate receptor is required for HIV-1 Gag release.

ITPR2 ITPR3

1.41e-05376220427533
Pubmed

N-Terminomics for the Identification of In Vitro Substrates and Cleavage Site Specificity of the SARS-CoV-2 Main Protease.

TBC1D19 PRRC2C MCCC1 ANKHD1 UTRN CDC42BPB ITPR3

1.42e-0536076733111431
Pubmed

A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning.

TCF3 ANKS6 SMG7 DROSHA KLF5 CRYBG1 RPRD2 POC5 XPO1 MLXIP MADD

1.55e-051038761126673895
Pubmed

Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.

SMG7 RPN2 LMTK2 POC5 XPO1 UTRN CDC42BPB MADD ITPR2 ITPR3 NIN

1.70e-051049761127880917
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

PRRC2C N4BP2 HJURP LMTK2 ANKRD17 MCCC1 MLXIP UTRN USP6NL MADD

1.79e-05861761036931259
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

SMG7 PHRF1 LMTK2 ANKRD17 RPRD2 ANKHD1 USP6NL NIN

2.07e-0552976814621295
Pubmed

Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.

MFAP3 SLC7A13 HJURP DDX42 LMTK2 ANKRD17 CRYBG1 ZCCHC2 ANKHD1 UTRN MADD

2.30e-051084761111544199
Pubmed

Loss of IP3R-dependent Ca2+ signalling in thymocytes leads to aberrant development and acute lymphoblastic leukemia.

ITPR2 ITPR3

2.82e-05476225215520
Pubmed

Abnormal taste perception in mice lacking the type 3 inositol 1,4,5-trisphosphate receptor.

ITPR2 ITPR3

2.82e-05476217925404
Pubmed

Inositol 1, 4, 5-trisphosphate receptor interacts with the SNARE domain of syntaxin 1B.

ITPR2 ITPR3

2.82e-05476221424589
Pubmed

Gene fusion and overlapping reading frames in the mammalian genes for 4E-BP3 and MASK.

ANKRD17 ANKHD1

2.82e-05476214557257
Pubmed

IRE1α/XBP1-mediated branch of the unfolded protein response regulates osteoclastogenesis.

ITPR2 ITPR3

2.82e-05476226193638
Pubmed

Loss of IP3 Receptor-Mediated Ca2+ Release in Mouse B Cells Results in Abnormal B Cell Development and Function.

ITPR2 ITPR3

2.82e-05476228615414
Pubmed

Distinct localization and function of (1,4,5)IP(3) receptor subtypes and the (1,3,4,5)IP(4) receptor GAP1(IP4BP) in highly purified human platelet membranes.

ITPR2 ITPR3

2.82e-05476210828023
Pubmed

3'-UTR Polymorphisms in the MiRNA Machinery Genes DROSHA, DICER1, RAN, and XPO5 Are Associated with Colorectal Cancer Risk in a Korean Population.

XPO5 DROSHA

2.82e-05476226147304
Pubmed

SUMOylation regulates nuclear localization of Krüppel-like factor 5.

KLF5 XPO1

2.82e-05476218782761
Pubmed

IP3R-mediated Ca2+ signals govern hematopoietic and cardiac divergence of Flk1+ cells via the calcineurin-NFATc3-Etv2 pathway.

ITPR2 ITPR3

2.82e-05476228419336
Pubmed

The kinetochore protein, CENPF, is mutated in human ciliopathy and microcephaly phenotypes.

CENPF NIN

2.82e-05476225564561
Pubmed

Analysis of microRNA processing machinery gene (DROSHA, DICER1, RAN, and XPO5) variants association with end-stage renal disease.

XPO5 DROSHA

2.82e-05476232770606
Pubmed

Alternative splice variants of hTrp4 differentially interact with the C-terminal portion of the inositol 1,4,5-trisphosphate receptors.

ITPR2 ITPR3

2.82e-05476211163362
Pubmed

IP3R-mediated Ca2+ signaling controls B cell proliferation through metabolic reprogramming.

ITPR2 ITPR3

2.82e-05476235494252
Pubmed

TRIM24 is an insulin-responsive regulator of P-bodies.

SMG7 ANKRD17 XPO1 ANKHD1

2.94e-058076435803934
Pubmed

Systematic analysis of human protein complexes identifies chromosome segregation proteins.

SERPINA1 CENPF HJURP DDX42 SASS6 SGO2 PROSER1 POC5 XPO1 FBXO30 CREB3L2

4.10e-051155761120360068
Pubmed

Defining the membrane proteome of NK cells.

PCYOX1L RPN2 PRRC2C STAU2 PHRF1 DDX42 ANKRD17 LRRC40 XPO1 ITPR2 ITPR3

4.54e-051168761119946888
Pubmed

Isolation of novel tissue-specific genes from cDNA libraries representing the individual tissue constituents of the gastrulating mouse embryo.

LRRC19 ANKRD17 RPRD2 BICRAL SLC39A8 HYAL2 FBXO30

4.54e-054327677671812
Pubmed

InsP₃receptors and Orai channels in pancreatic acinar cells: co-localization and its consequences.

ITPR2 ITPR3

4.69e-05576221568942
Pubmed

Calmodulin protects against alcohol-induced pancreatic trypsinogen activation elicited via Ca2+ release through IP3 receptors.

ITPR2 ITPR3

4.69e-05576221436055
Pubmed

An inducible CRISPR/Cas9 screen identifies DTX2 as a transcriptional regulator of human telomerase.

TCF3 VGLL3 RPRD2 MCCC1 USP6NL

4.82e-0518076535198878
Pubmed

Roles of I(f) and intracellular Ca2+ release in spontaneous activity of ventricular cardiomyocytes during murine embryonic development.

ITPR2 ITPR3

7.03e-05676223463619
Pubmed

Sprouty2 regulates PI(4,5)P2/Ca2+ signaling and HIV-1 Gag release.

ITPR2 ITPR3

7.03e-05676221762810
Pubmed

A calcium-induced calcium release mechanism supports luteinizing hormone-induced testosterone secretion in mouse Leydig cells.

ITPR2 ITPR3

7.03e-05676220519450
Pubmed

Essential Roles of Intracellular Calcium Release Channels in Muscle, Brain, Metabolism, and Aging.

ITPR2 ITPR3

7.03e-05676225966694
Pubmed

IP3Rs are sufficient for dendritic cell Ca2+ signaling in the absence of RyR1.

ITPR2 ITPR3

7.03e-05676216844763
Pubmed

Genome-Wide CRISPR-Cas9 Screens Expose Genetic Vulnerabilities and Mechanisms of Temozolomide Sensitivity in Glioblastoma Stem Cells.

SMG7 PRRC2C ANKRD17 ANKHD1

9.16e-0510776430995489
Pubmed

Developmental expression of the calcium release channels during early neurogenesis of the mouse cerebral cortex.

ITPR2 ITPR3

9.83e-05776211860456
Pubmed

Inositol-1,4,5-trisphosphate receptor regulates hepatic gluconeogenesis in fasting and diabetes.

ITPR2 ITPR3

9.83e-05776222495310
Pubmed

H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.

TCF3 CENPF RPN2 KLF5 PHRF1 DDX42 RPRD2 MCCC1 MLXIP CREB3L2 ITPR3

1.13e-041294761130804502
Pubmed

Roles of IP3R and RyR Ca2+ channels in endoplasmic reticulum stress and beta-cell death.

ITPR2 ITPR3

1.31e-04876219033399
Pubmed

Black carbon exposures, blood pressure, and interactions with single nucleotide polymorphisms in MicroRNA processing genes.

XPO5 DROSHA

1.31e-04876220211803
Pubmed

Identification of molecular markers that are expressed in discrete anterior-posterior domains of the endoderm from the gastrula stage to mid-gestation.

KLF5 SLC39A8

1.31e-04876217576135
Pubmed

Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.

SMG7 XPO5 RPRD2 CDC42BPB NIN

1.38e-0422576512168954
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

PIKFYVE ANKS6 LMTK2 MLXIP ANKHD1 ZNF839 CDC42BPB MADD ITPR2 ITPR3

1.44e-041105761035748872
Pubmed

A novel heterodimerization domain, CRM1, and 14-3-3 control subcellular localization of the MondoA-Mlx heterocomplex.

XPO1 MLXIP

1.68e-04976212446771
Pubmed

Ca2+ signals regulate mitochondrial metabolism by stimulating CREB-mediated expression of the mitochondrial Ca2+ uniporter gene MCU.

ITPR2 ITPR3

1.68e-04976225737585
Pubmed

A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.

SMG7 RPN2 PRRC2C STAU2 ANKRD17 MCCC1 ANKHD1 CDC42BPB

1.84e-0472476836232890
Pubmed

N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.

SMG7 PRRC2C STAU2 DDX42 ANKRD17 RPRD2 MCCC1 ANKHD1 UTRN

1.99e-0493476933916271
Pubmed

E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.

MXRA5 CENPF DROSHA MYO3B LRRC40 GSDMC UTRN ITPR2

2.06e-0473676829676528
Pubmed

A protein inventory of human ribosome biogenesis reveals an essential function of exportin 5 in 60S subunit export.

XPO5 XPO1

2.10e-041076221048991
Pubmed

Association of a common AGO1 variant with lung cancer risk: a two-stage case-control study.

XPO5 DROSHA

2.10e-041076220721975
Pubmed

Type 1 and 3 inositol trisphosphate receptors are required for extra-embryonic vascular development.

ITPR2 ITPR3

2.56e-041176227514653
Pubmed

Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.

CENPF N4BP2 ANKRD17 MCCC1 ANKHD1 UTRN

3.13e-0441876634709266
Pubmed

Demethylation of H3K27 regulates polycomb recruitment and H2A ubiquitination.

N4BP2 PROSER1

3.62e-041376217761849
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

TBC1D19 PCYOX1L TCF3 SMG7 ANKRD17 CHD9 RPRD2 ZNF839 UTRN CDC42BPB CREB3L2

3.79e-041489761128611215
Pubmed

Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.

LMTK2 ANKRD17 SGO2 RPRD2 ITPR2 ITPR3

4.10e-0444076634244565
Pubmed

Role of primary miRNA polymorphic variants in metastatic colon cancer patients treated with 5-fluorouracil and irinotecan.

XPO5 DROSHA

4.22e-041476220585341
InteractionLRRC31 interactions

XPO5 RPN2 PRRC2C ANKRD17 CRYBG1 XPO1 CDC42BPB ITPR3

7.63e-07205738int:LRRC31
InteractionCNOT9 interactions

SMG7 PRRC2C N4BP2 SASS6 ANKRD17 RPRD2 XPO1 ANKHD1

1.87e-06231738int:CNOT9
InteractionEGLN3 interactions

TCF3 VGLL3 SMG7 CENPF DROSHA N4BP2 KLF5 HJURP ANKRD17 SGO2 LRRC40 PROSER1 XPO1 ANKHD1 UTRN FBXO30 NIN

2.81e-0612967317int:EGLN3
InteractionDAZL interactions

SMG7 PRRC2C N4BP2 STAU2 ANKRD17 ZCCHC2

1.43e-05145736int:DAZL
InteractionYTHDF3 interactions

SMG7 PRRC2C KLF5 ANKRD17 XPO1 ZCCHC2 ANKHD1

3.04e-05246737int:YTHDF3
InteractionRNF214 interactions

SMG7 PRRC2C N4BP2 ANKRD17 POC5

3.78e-05104735int:RNF214
InteractionCNOT2 interactions

SMG7 PRRC2C N4BP2 ANKRD17 XPO1 ANKHD1

4.55e-05178736int:CNOT2
InteractionOST4 interactions

SMG7 RPN2 STAU2 ANKRD17 ANKHD1

4.73e-05109735int:OST4
InteractionSIRT7 interactions

XPO5 CENPF RPN2 PRRC2C PHRF1 DDX42 ANKRD17 XPO1 ANKHD1 UTRN ITPR3

7.12e-057447311int:SIRT7
InteractionHAUS2 interactions

PRRC2C SASS6 POC5 XPO1 NIN

9.43e-05126735int:HAUS2
InteractionRBMS1 interactions

SMG7 PRRC2C N4BP2 STAU2 ANKRD17 XPO1

1.05e-04207736int:RBMS1
InteractionTDRD3 interactions

SMG7 PRRC2C N4BP2 STAU2 ANKRD17 POC5

1.20e-04212736int:TDRD3
Cytoband6q24

UTRN FBXO30

7.52e-0587626q24
Cytoband8q21.3

CNBD1 SLC7A13

1.07e-03297628q21.3
Cytoband7q22

MUC12 MUC3A

1.83e-03387627q22
GeneFamilyInositol 1,4,5-triphosphate receptors|Protein phosphatase 1 regulatory subunits

ITPR2 ITPR3

1.73e-053442297
GeneFamilyExportins

XPO5 XPO1

1.21e-047442547
GeneFamilyCD molecules|Mucins

MUC12 MUC3A

1.18e-0321442648
GeneFamilyArmadillo repeat containing|Protein phosphatase 1 regulatory subunits

PHRF1 LMTK2 ITPR3

9.67e-03181443694
CoexpressionGSE21380_NON_TFH_VS_GERMINAL_CENTER_TFH_CD4_TCELL_DN

TBC1D19 PHYH DDX42 XPO1 UTRN MADD CCDC158

1.90e-06200767M7505
CoexpressionMCCLUNG_COCAIN_REWARD_4WK

SERPINA1 TCF3 KLF5 ANKHD1 ITPR2

2.47e-0674765M1600
CoexpressionMCCLUNG_COCAIN_REWARD_4WK

SERPINA1 TCF3 KLF5 ANKHD1 ITPR2

2.82e-0676765MM682
CoexpressionGSE10500_ARTHRITIC_SYNOVIAL_FLUID_VS_HEALTHY_MACROPHAGE_DN

TBC1D19 STAU2 UTRN CDC42BPB IL23R ITPR2

4.11e-06145766M359
CoexpressionDAZARD_RESPONSE_TO_UV_NHEK_DN

PIKFYVE CENPF CHD9 BICRAL XPO1 USP6NL CREB3L2

2.67e-05300767M8702
CoexpressionGSE12963_ENV_NEF_VS_ENV_NEF_AND_VPR_DEFICIENT_HIV1_INF_CD4_TCELL_UP

LRRC19 BICRAL MLXIP ZCCHC2 USP6NL

4.47e-05134765M455
CoexpressionGEORGES_TARGETS_OF_MIR192_AND_MIR215

VGLL3 HCN4 CENPF N4BP2 HJURP SASS6 SGO2 BICRAL XPO1 SLC39A8 NIN

5.07e-058927611M18120
CoexpressionDACOSTA_UV_RESPONSE_VIA_ERCC3_COMMON_DN

PIKFYVE CENPF PRRC2C STAU2 ANKRD17 CHD9 XPO1 CREB3L2

6.15e-05466768M13522
CoexpressionGSE4590_PRE_BCELL_VS_VPREB_POS_LARGE_PRE_BCELL_UP

PHYH STAU2 ANKRD17 ZCCHC2 IL23R

9.49e-05157765M6867
CoexpressionLIAN_LIPA_TARGETS_6M

C3AR1 RP1 MS4A6A UTRN

9.62e-0582764M4345
CoexpressionPATIL_LIVER_CANCER

SMG7 XPO5 CENPF PRRC2C HJURP LMTK2 RPRD2 XPO1 CREB3L2

1.22e-04660769M1195
CoexpressionGSE10147_IL3_VS_IL3_AND_HIVP17_STIM_PDC_UP

TBC1D19 RPRD2 MLXIP TFDP2 ITPR2

1.23e-04166765M344
CoexpressionAIZARANI_LIVER_C8_RESIDENT_B_CELLS_1

SPAG4 MEI1 CREB3L2

1.43e-0435763M39112
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid-Macrophage_Dendritic-Cycling_Mononuclear_Phagocyte|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

CENPF HJURP SGO2 C3AR1 TGM7 MS4A6A

8.17e-0718776673931a5ea73799095daff100b5f18853c57c74dc
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Sst-Sst_Hpse_Sema3c|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

CNBD1 VGLL3 KLF5 GSDMC UTRN

2.14e-06122765eae9d94f8510ac0f434942451d55c7260977b178
ToppCell3'-Parenchyma_lung-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell-Deuterosomal|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CENPF SASS6 SGO2 MUC12 CCDC158

1.42e-051807650c146e80d55d18b6988dd21b1da635801bd3140c
ToppCell3'-Parenchyma_lung-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CENPF SASS6 SGO2 MUC12 CCDC158

1.42e-05180765e9af22beae2f3c7fe213b4e19df84abfd2453433
ToppCell3'-Parenchyma_lung-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell-Deuterosomal-Deuterosomal_L.0.3.4.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CENPF SASS6 SGO2 MUC12 CCDC158

1.42e-0518076511455ba704ac73f69b474845136cfecec6a88349
ToppCell3'-Child04-06-SmallIntestine-Hematopoietic-Plasma_cells-IgA_plasma_cell|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SPAG4 CENPF RPN2 SGO2 MEI1

1.62e-05185765ff598af88c7f9d7224cc4ed96b1c3463ef76b550
ToppCellNS-moderate-d_0-4-Myeloid-Non-resident_Macrophage|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

SERPINA1 C3AR1 MEI1 MS4A6A ITPR2

1.71e-05187765fcc32dbc9c5ae6176f154715a3e73aa32d78ad64
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

KLF5 MYO3B RP1 MUC12 ITPR3

1.71e-0518776587b3d0478693d4c54ff06b74e5903036b9c1ee6a
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

KLF5 MYO3B RP1 MUC12 ITPR3

1.71e-0518776542a1267bfc27b4460b8409ada580a87c4385841c
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

KLF5 MYO3B RP1 MUC12 ITPR3

1.71e-0518776564afdea159f5e67a1e5cea35ce898aae6e80aea5
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

VGLL3 MXRA5 KLF5 MYO3B CRYBG1

2.09e-051957653d6d3de8ada6dce3dc789c15b50cc066e7100496
ToppCellB_cells-Plasma_cells_and_plasmablasts|B_cells / Immune cells in Kidney/Urine in Lupus Nephritis

SPAG4 RPN2 MEI1 SLC39A8 CREB3L2

2.20e-051977653b1c574b3d119b63967bb1306f0353ecc4c522f3
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_no-steroids-Myeloid-Monocytic-Classical_Monocyte-Mono_c3-CD14-VCAN|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

SERPINA1 C3AR1 MS4A6A SLC39A8

6.05e-05124764e9b6fdac2bef4bf1fee6a486f4628b68adc80f57
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Sst-Sst_Chrna2_Ptgdr|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

VGLL3 KLF5 GSDMC UTRN

6.24e-05125764d05556ea185c15815a4f8643f1c01185badbeece
ToppCellTCGA-Stomach-Primary_Tumor-Stomach_Adenocarcinoma-Stomach_Adenocarcinoma_-_Tubular|TCGA-Stomach / Sample_Type by Project: Shred V9

SMG7 XPO5 CENPF PROSER1

9.16e-0513876493497c0a5d5e54006653b2dedc7a7041e1a613e6
ToppCellAdult-Immune-B_cell-D122|Adult / Lineage, Cell type, age group and donor

TCF3 SPAG4 MEI1 CREB3L2

1.43e-041557645857aebd43b901fc9f8c46f2d628582969db9e6a
ToppCellPND10-Endothelial-Endothelial_blood-vessel-Microvascular_EC-EPC-EPC_mature|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PCYOX1L CENPF HJURP SGO2

1.74e-041637643efbbdc9cb2613bb76d8c2f07cd4ec1a2c51a622
ToppCellLPS-antiTNF-Endothelial-Endothelial-FOXM1|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CENPF HJURP SASS6 SGO2

1.74e-041637645285318c52aa31c9b22dc2ffff078e32e408604d
ToppCell390C-Myeloid-Dendritic-cDC_proliferating_2|390C / Donor, Lineage, Cell class and subclass (all cells)

CENPF HJURP SGO2 MS4A6A

1.78e-04164764ad508f53009efdd1dae7abcdb5431387f3f7e7b2
ToppCell367C-Myeloid-Dendritic-cDC_proliferating_2|367C / Donor, Lineage, Cell class and subclass (all cells)

CENPF HJURP SGO2 PROSER1

1.78e-041647640662cd9d21608efacc336e0a582859f3b9a4951d
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_G2M|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PCYOX1L CENPF HJURP SGO2

1.78e-041647641642a67c66eeb77a218e7814e3cfe517d9822955
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PCYOX1L CENPF HJURP SGO2

1.78e-0416476425758fb8112baf296264122d5d4121f1ebb3d0fa
ToppCellPosterior_cortex-Neuronal-Inhibitory|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

SPAG4 PRRC2C MYO3B SP9

1.91e-041677649a84f45345c75f2c8ff38a04245aadee2a26a240
ToppCellHippocampus-Neuronal-Inhibitory-iN2(Gad1Gad2)|Hippocampus / BrainAtlas - Mouse McCarroll V32

SPAG4 PRRC2C MYO3B SP9

2.00e-04169764c135d7ae0490d0024e0f4bd8c4ad42f6674a61da
ToppCellBrain_organoid-organoid_Kanton_Nature-Organoid-1M-Proliferating-cycling_ventral_progenitors|Organoid-1M / Sample Type, Dataset, Time_group, and Cell type.

CENPF HJURP SP9 SGO2

2.04e-0417076473601c873b177d5d134618d8e228c51381119f7d
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Macrophage_Dendritic-Cycling_Mononuclear_Phagocyte|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

CENPF HJURP MS4A6A IL23R

2.09e-0417176455c7bf7211587fa08df13c0a4ff5b78a85d5439e
ToppCellPND10-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1-AF1_G2M|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

VGLL3 CENPF HJURP SGO2

2.14e-0417276429c8510f26527d487d0fc3543102d067cdb281a6
ToppCellPND28-Endothelial-Endothelial_blood-vessel-Microvascular_EC-EPC-EPC_G2M|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CENPF HJURP SASS6 SGO2

2.23e-0417476472df66319f6efbd88ecf439013d97409fbf3cb52
ToppCellPND28-Endothelial-Endothelial_blood-vessel-Microvascular_EC-EPC|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CENPF HJURP SASS6 SGO2

2.23e-04174764c6087fd0e036ec7f40f0f8f17d1f6ce13ddb5235
ToppCell343B-Myeloid-Dendritic-cDC_proliferating_2|343B / Donor, Lineage, Cell class and subclass (all cells)

CENPF HJURP C3AR1 MS4A6A

2.23e-04174764a75ba49ccea6bd3d78ada1092b46deb5202c58a5
ToppCell5'-Parenchyma_lung-Immune_Myeloid-Myeloid_monocytic-classical_monocyte-Classical_monocytes-Classical_monocytes_L.1.2.4.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

C3AR1 ZCCHC2 MS4A6A IL23R

2.23e-04174764b6e3fa995def40a8fbdfc249fe108c303931a171
ToppCell5'-Adult-LymphNode-Hematopoietic-Plasma_cells|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SPAG4 RPN2 MEI1 CREB3L2

2.28e-041757646a093c74a6f3daeff07759d6eec542fc5c709149
ToppCell390C-Lymphocytic-NK_cells-NK_cell_A2|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

SERPINA1 SASS6 ZNF839 CDC42BPB

2.28e-04175764334fad1a147de6c007cec5089c02c35cf3220f1b
ToppCell390C-Lymphocytic-NK_cells-NK_cell_A2|NK_cells / Donor, Lineage, Cell class and subclass (all cells)

SASS6 C3AR1 ZNF839 CDC42BPB

2.28e-04175764da191dfb8a7f976a632a3a0b923942ab54f5c8c1
ToppCellmetastatic_Brain-B_lymphocytes-GrB-secreting_B_cells|B_lymphocytes / Location, Cell class and cell subclass

LMTK2 MCCC1 MS4A6A GSDMC

2.38e-0417776443e1d0d3cf8f0c02e67d91f8dd1761df23d59e07
ToppCellPND14-Endothelial-Endothelial_blood-vessel-Microvascular_EC-EPC|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CENPF HJURP SASS6 SGO2

2.49e-0417976454191c00b29f53b520cd3243b5791daa4a2c72d7
ToppCellPND14-Endothelial-Endothelial_blood-vessel-Microvascular_EC-EPC-EPC_G2M|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CENPF HJURP SASS6 SGO2

2.54e-041807645e1680088065be14447d5d5465f91f7edd071a1e
ToppCell3'-Pediatric_IBD-SmallIntestine-Hematopoietic-B_cells-Cycling_plasma_cell|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SPAG4 CENPF HJURP SGO2

2.54e-04180764ce2fc270f9d9110c2544083f61936b0b7d3b7eb3
ToppCell10x5'-lymph-node_spleen-Myeloid_Mac-Cycling_Myeloid-Mac|lymph-node_spleen / Manually curated celltypes from each tissue

CENPF HJURP SGO2 MS4A6A

2.54e-041807644eea8366cdb82c356325ce88f09ad8b302c17a07
ToppCellcellseq-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Deuterosomal|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

CENPF SP9 SGO2 MUC12

2.65e-04182764deb53a4f84e4cd5c3b4180a4ac43249da9d738f7
ToppCellCOVID-19-B_cells-Plasma_cells|COVID-19 / group, cell type (main and fine annotations)

TCF3 SPAG4 MEI1 CREB3L2

2.70e-04183764130c109f63a5e3c8f83cb96e32f4addf513b6415
ToppCellCOVID-19-B_cells|COVID-19 / group, cell type (main and fine annotations)

TCF3 SPAG4 MEI1 CREB3L2

2.70e-041837642c016bb59f131a0e821853b085289a3583f0a729
ToppCell10x5'-GI_large-bowel-Lymphocytic_B_plasma-Plasma_cells|GI_large-bowel / Manually curated celltypes from each tissue

SPAG4 RPN2 MEI1 CREB3L2

2.82e-041857642cad994207c4afc9d70f4c2d243ffbbcdbba693e
ToppCell10x5'-GI_large-bowel-Lymphocytic_B_plasma|GI_large-bowel / Manually curated celltypes from each tissue

SPAG4 RPN2 MEI1 CREB3L2

2.82e-04185764989583c487d8c121e3731faf68f863ba43a582e6
ToppCell3'-Child04-06-SmallIntestine-Hematopoietic-Plasma_cells|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SPAG4 RPN2 MEI1 CREB3L2

2.88e-04186764b9fb7210f615faff0633a1c82dd3be38cb72a00b
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-TAM-BDM-TAM-BDM_INF|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

CNBD1 SERPINA1 C3AR1 MS4A6A

2.88e-04186764e4de270d38bbed022f545bd0bbaa9599e707ec87
ToppCellDendritic_Cells-Donor_01|World / lung cells shred on cell class, cell subclass, sample id

KLF5 C3AR1 XPO1 MS4A6A

2.88e-041867641d52912bd17e232cf39b2423a4d93585c164ba34
ToppCell3'-Child04-06-SmallIntestine-Hematopoietic-Plasma_cells-IgM_plasma_cell|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

RPN2 MEI1 CREB3L2 ITPR2

2.88e-04186764a67e818c5ab682c2058fccc85f3fade0e11cb56e
ToppCell5'-Parenchyma_lung-Endothelial-Lymphatic_EC-endothelial_cell_of_lymphatic_vessel-Lymphatic_EC_proliferating|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CENPF HJURP SGO2 HYAL2

2.88e-041867645d527050cd554cc46c6d8dcb7981900725d79fc6
ToppCell5'-Parenchyma_lung-Endothelial-Lymphatic_EC-endothelial_cell_of_lymphatic_vessel-Lymphatic_EC_proliferating-Lymphatic_EC_proliferating_L.2.5.4.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CENPF HJURP SGO2 HYAL2

2.88e-04186764ee1c3e2adfa2900542200a218746b576c7ed10dc
ToppCell3'-Pediatric_IBD-SmallIntestine-Hematopoietic-Plasma_cells|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SPAG4 RPN2 MEI1 CREB3L2

2.94e-0418776431f36e34669b8fff6905262b4661b59c93e4dc3d
ToppCellB_cell_maturation-immature_B_cell|B_cell_maturation / Lineage and Cell class

TCF3 MLXIP MS4A6A TFDP2

2.94e-041877649afbb21654c8eb6f9c6a7cbd0664d890282ddceb
ToppCell5'-Parenchyma_lung-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell-Deuterosomal-Deuterosomal_L.0.3.4.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CENPF SGO2 MUC12 CCDC158

2.94e-04187764269145d71576cbe8fa217090c8aac82d915dbc04
ToppCell5'-Parenchyma_lung-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CENPF SGO2 MUC12 CCDC158

2.94e-041877647a50aded3243bef2075fb3ec550939ce0694919a
ToppCellP03-Endothelial-large_vessel_endothelial_cell-endothelial_cell_of_artery|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

GPR21 UTRN HYAL2 ITPR3

2.94e-0418776466ebe1788d51b3e17bec6cdb219f709756b4e530
ToppCell5'-Parenchyma_lung-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell-Deuterosomal|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CENPF SGO2 MUC12 CCDC158

2.94e-04187764629b3e05840eb10e598b8dfaabd92ebe02f9995a
ToppCell5'-GW_trimst-2-LargeIntestine-Epithelial-epithelial_progenitor_cell-TA|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CENPF KLF5 HJURP SGO2

3.00e-04188764b3cae49f0665ace0016a6441cbf9ae40755b0ea3
ToppCellSmart-seq2-bone_marrow_(Smart-seq2)|Smart-seq2 / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

SPAG4 CENPF HJURP CREB3L2

3.00e-04188764557a0ac069a6ff4e687cac032f64170b9b247165
ToppCell3'-Pediatric_IBD-SmallIntestine-Hematopoietic-Plasma_cells-IgA_plasma_cell|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SPAG4 RPN2 MEI1 CREB3L2

3.00e-04188764fd4d304f1cb41e694d21b5441739eb34a5a13b04
ToppCelldroplet-Heart-nan-3m-Endothelial-endocardial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PCYOX1L SLC39A8 HYAL2 ITPR2

3.06e-041897648e583ec4df0f5b79ce5211cc99ecd8616d180bde
ToppCellCOVID-19_Convalescent-Classical_Monocyte-cMono_3|Classical_Monocyte / Disease condition and Cell class

PCYOX1L C3AR1 ANKHD1 HYAL2

3.06e-041897648b6f92ccfffc743c07201bc971b3dc1a6fa14ccc
ToppCellsystemic_lupus_erythematosus-managed-Lymphocytic_B-B_plasma-female|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

CENPF RPN2 HJURP MEI1

3.06e-0418976459e6fec454de621119571d4a8ec48be3bf02a32e
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

VGLL3 MXRA5 MYO3B CRYBG1

3.06e-04189764bfc76a72b600d641c8fe58346e5d8986c34f3981
ToppCell5'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_II_pneumocyte-AT2-AT2_L.0.1.3.2|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SERPINA1 MUC3A SLC39A8 ITPR3

3.06e-04189764da014519d6eb21bc2dc2ed65eafe638b42a068ed
ToppCellrenal_medulla_nuclei|World / Celltypes from Cells and Nuclei per compartment and clinical group

MYO3B ANKRD17 RP1 UTRN

3.06e-04189764830d9cd0dd706bce22eb2416f07b2c31c870a05a
ToppCellControl-Endothelial-Endothelial-FOXM1|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CENPF HJURP SASS6 SGO2

3.06e-041897641e1499b062d9c647c8f38b0c4e0d871d159be5dd
ToppCellsystemic_lupus_erythematosus-managed-Lymphocytic_B-B_plasma|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

CENPF RPN2 HJURP MEI1

3.06e-0418976443f25fb7257eab05df921ffcd5a6e49c78a03e3a
ToppCelldroplet-Heart-nan-3m-Endothelial-endocardial_endothelial_cells|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PCYOX1L SLC39A8 HYAL2 CREB3L2

3.06e-04189764fb2253b8463d08b3d28e952a31a23dea2c2d986b
ToppCellSmart-seq2-lymph_node_(Smart-seq2)-lymphocytic-B_lymphocytic-plasma_cell|lymph_node_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

SPAG4 RPN2 MEI1 CREB3L2

3.12e-0419076476b747bafff09bf8375a5717c9f213cbfb405bac
ToppCellmetastatic_Lymph_Node-B_lymphocytes-MALT_B_cells|B_lymphocytes / Location, Cell class and cell subclass

SPAG4 RPN2 MEI1 CREB3L2

3.12e-041907645ec49cc7692053c1a525ca9137c996ccd2794e1c
ToppCellPBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Myeloid-Macrophage|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)

SERPINA1 C3AR1 MS4A6A SLC39A8

3.12e-04190764e1c02fe6fa43a36381cb9f02569fa9b1c5f5efdc
ToppCell367C-Lymphocytic-NK_cells-NK_cell_B1|NK_cells / Donor, Lineage, Cell class and subclass (all cells)

N4BP2 LMTK2 BICRAL MS4A6A

3.12e-041907642434b8ad2976eab7d9147012c28454ab29670709
ToppCellnormal_Lymph_Node-B_lymphocytes-MALT_B_cells|normal_Lymph_Node / Location, Cell class and cell subclass

SPAG4 RPN2 MEI1 CREB3L2

3.12e-041907641f907016980ccfbf089e354d91d931771e8a83e0
ToppCelltumor_Lymph_Node_/_Brain-B_lymphocytes-MALT_B_cells|B_lymphocytes / Location, Cell class and cell subclass

SPAG4 RPN2 MEI1 CREB3L2

3.12e-04190764ce70336679a2b713836e7497e6dc48aac612b018
ToppCellPBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Myeloid-Macrophage-macrophage,_alveolar|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)

SERPINA1 C3AR1 MS4A6A SLC39A8

3.12e-041907646de15ec88426fbf52acb0a8371f82cf03b6a6237
ToppCellpdx-Tumor_cells-T1|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)

CENPF HJURP SGO2 XPO1

3.12e-04190764d06ee5f89f1cec8db6897fe3b2a890a07cd3697b
ToppCellEndothelial-D_(cycle)|World / shred on cell class and cell subclass (v4)

CENPF HJURP SASS6 SGO2

3.18e-0419176449a4d8f181558e3be9527a8ff9a178f3bb01323c
ToppCell10x3'2.3-week_17-19-Lymphocytic_B-B_lineage-pro_B_progenitor|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

CHD9 XPO1 MLXIP UTRN

3.18e-0419176440813c397f533c2f4a6359a77757f736b6d9e07d
ToppCellDividing_Macrophages-HP_01|World / lung cells shred on cell class, cell subclass, sample id

CENPF HJURP SASS6 SGO2

3.18e-041917643e567ed6b5fefafa7f460e49d25d60bb52a0a6c8
ToppCell10x5'v1-week_12-13-Lymphocytic_B-B_lineage-pro_B_progenitor|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

TCF3 CHD9 MLXIP UTRN

3.18e-04191764054fa0493b00149313c243d39cf39a264044f074
ToppCell3'-Broncho-tracheal-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophage_proliferating-Alveolar_macrophage_proliferating_L.1.0.7.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CENPF HJURP SGO2 MS4A6A

3.18e-04191764d6e158f16a183c9203c057192342e9b83e79bc89
ToppCell3'-Broncho-tracheal-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophage_proliferating|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CENPF HJURP SGO2 MS4A6A

3.18e-041917647cb5c6f2cf27f3503d1b313e402a7410dfe6473e
ToppCellkidney_cells-Hypertensive_with+without-CKD-Immune-Myeloid-Macrophage_Dendritic-Cycling_Mononuclear_Phagocyte|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

CENPF HJURP SGO2 MS4A6A

3.18e-04191764ff2cc4c10aa584b3daeaaf23cd8ee09bdbdf684d
ToppCellPCW_10-12-Epithelial-Epithelial_proliferating-epi_proliferating2_(13)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

CENPF MYO3B HJURP SGO2

3.18e-0419176439220f4a345e328f7fa4fd462a0abeea821b3e02
ToppCell3'_v3-bone_marrow-Myeloid_Dendritic-Cycling_Dendritic|bone_marrow / Manually curated celltypes from each tissue

CENPF HJURP SGO2 MS4A6A

3.18e-04191764aa9c0b1b90cdb7a95d4e6332819f82cae0a79ff9
ToppCellSmart-seq2-spleen_(Smart-seq2)-lymphocytic-B_lymphocytic-plasma_cell|spleen_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

SPAG4 RPN2 MEI1 CREB3L2

3.18e-041917647b4b5d90d1023d03239ed986f273afa734d3124d
ToppCell367C-Lymphocytic-NK_cells-NK_cell_B1|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

N4BP2 LMTK2 BICRAL MS4A6A

3.18e-0419176439ef8e1d7cc3ebb11717e8a55501515e3b72b177
ToppCellEndothelial-Endothelial-D_(cycle)|Endothelial / shred on cell class and cell subclass (v4)

CENPF HJURP SASS6 SGO2

3.18e-04191764a3c5a913a99f17633c140ec9ece81b73e59e0715
ToppCellPBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Myeloid-Macrophage-macrophage,_alveolar-Macro_c2-CCL3L1|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)

SERPINA1 C3AR1 MS4A6A SLC39A8

3.18e-0419176481f77bf497b8e0ae0affe7d5f4f00446547229f6
ToppCellPCW_10-12-Hematologic_Myeloid-Hem_Myeloid_monocytic-im_monocyte_(14)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

SERPINA1 C3AR1 MS4A6A SLC39A8

3.24e-04192764d44f46352bac414b45cc749f7cbdc3a159bd7ae8
ToppCellParenchymal-10x3prime_v2-Immune_Lymphocytic-B-B_plasma-B_plasma_IgA|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

SPAG4 MYO3B MEI1 CREB3L2

3.24e-041927643dddfc93c3c954c4416c7c1f1f161e4d1dcc1233
ToppCellfacs-Thymus-Flowthrough-3m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CENPF SASS6 SGO2 LRRC40

3.24e-04192764e8d47504b744040a762ec9b670a66cc060b2ae86
ToppCellPCW_10-12-Hematologic_Myeloid-Hem_Myeloid_monocytic-im_immature_monocyte2_(4)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

SERPINA1 C3AR1 MS4A6A SLC39A8

3.24e-04192764aa65557b35d3eba9f24b970849255d05174d1c05
ToppCell3'-GW_trimst-2-LargeIntestine-Epithelial-mature_enterocytic|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SERPINA1 LRRC19 KLF5 MUC3A

3.31e-0419376432eb026d4317c1499d51294d396dfd5f293f9deb
ToppCellSmart-seq2-thymus_(Smart-seq2)-lymphocytic-B_lymphocytic-plasma_cell|thymus_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

SPAG4 RPN2 MEI1 CREB3L2

3.31e-04193764bd82961502db42a0c862d3a29a2babe8032384c8
ToppCellNS-critical-d_0-4-Epithelial-Basal|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

ANKS6 DROSHA KLF5 POC5

3.31e-041937641affb4c2e21712bde0d36ab736411fe36642cc6d
ToppCell3'-GW_trimst-2-LargeIntestine-Epithelial-mature_enterocytic-Colonocyte|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SERPINA1 LRRC19 KLF5 MUC3A

3.31e-04193764930df79b0600f43617052313294be33bcf5631f0
ToppCellhuman_hepatoblastoma-Tumor_cells-T1|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)

CENPF HJURP SASS6 SGO2

3.31e-041937644b9fa2a4424f8abe63fa7bee78db93dda04ab15f
ToppCellILEUM-non-inflamed-(3)_MNP-(3)_DC1|(3)_MNP / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

CENPF KLF5 HJURP SGO2

3.31e-0419376442775588e788c330aade07e54b208f1c2eea3ab3
ToppCellCOVID_non-vent-Lymphocytic-Plasma_cell-IgM_Plasmablast|COVID_non-vent / Disease condition, Lineage, Cell class and subclass

TCF3 CENPF RPN2 HJURP

3.31e-041937647b4b0271e4fbece703876acb053ae236afb7cdba
Diseaseautosomal dominant cerebellar ataxia (implicated_via_orthology)

ITPR2 ITPR3

3.81e-0412722DOID:1441 (implicated_via_orthology)
Diseasetotal lipids in very large HDL measurement

POC5 SLC39A8 MADD

5.71e-0466723EFO_0022312
Diseasephospholipids in very large HDL measurement

POC5 SLC39A8 MADD

5.71e-0466723EFO_0022298
Diseasecholesterol in very large HDL measurement

POC5 SLC39A8 MADD

6.50e-0469723EFO_0022229
Diseasefree cholesterol in large HDL measurement

POC5 SLC39A8 MADD

9.64e-0479723EFO_0022157
Diseasemigraine disorder, Headache

HJURP RPRD2 ZCCHC2

1.23e-0386723HP_0002315, MONDO_0005277
Diseaseosteoarthritis, hip

RPRD2 MLXIP GSDMC

1.50e-0392723EFO_1000786
Diseasemultisite chronic pain

UTRN SLC39A8 ITPR3

1.64e-0395723EFO_0010100
Diseaseserum gamma-glutamyl transferase measurement

SERPINA1 KLF5 LMTK2 CHD9 RP1 CDC42BPB USP6NL SLC39A8

1.71e-03914728EFO_0004532
Diseaseneutrophil count

KLF5 CHD9 C3AR1 RPRD2 POC5 RP1 XPO1 ZCCHC2 MS4A6A ITPR2

1.87e-0313827210EFO_0004833
Diseasealpha fetoprotein measurement

SERPINA1 ANKRD17 CHD9

1.90e-03100723EFO_0010583
Diseaseatrial fibrillation

HCN4 XPO1 MEI1 SLC39A8 ITPR2

2.15e-03371725EFO_0000275
DiseaseBilateral Wilms Tumor

XPO5 DROSHA

2.28e-0329722C2930471
Diseasephospholipids:total lipids ratio

SERPINA1 POC5 SLC39A8 MADD

2.33e-03227724EFO_0020946

Protein segments in the cluster

PeptideGeneStartEntry
ESHLPATFSRSSQFT

BTNL10

236

A8MVZ5
AHQSNSTNIFFSPVS

SERPINA1

66

P01009
SFHTISPTLFNASSN

GSDMC

261

Q9BYG8
ATHLFSGRTFQSTSS

ADAM11

326

O75078
SVTPSSTHLGNFASN

ANKRD17

2331

O75179
STHLKLFPSASSNSF

C3AR1

291

Q16581
LQETSSSSFLSSQPF

HJURP

236

Q8NCD3
FNSPFSDNSTSLQTH

ITPR2

1491

Q14571
INAFFSSPFSENSTS

ITPR3

1476

Q14573
FSSHLLADSSSPATN

POC5

121

Q8NA72
PSASTFLHLSTNSFR

HYAL2

381

Q12891
NHSTSFSLSNLTLPT

MADD

856

Q8WXG6
NSPNTVSSSSVFTFA

KIAA2026

1301

Q5HYC2
TPQNSTSALSFHDLS

KIAA1109

2531

Q2LD37
LPQQSHSAFGATSSS

DDX42

31

Q86XP3
ATPLHLDNSSSNLTF

PCYOX1L

301

Q8NBM8
NTTSSSSNFLLTAFP

OR51T1

6

Q8NGJ9
NATHSTPNFTSSITT

MUC3A

2136

Q02505
PQSLQSAFSGHSSFL

DBX1

26

A6NMT0
AHSSQLSSPGFCNTF

PHRF1

786

Q9P1Y6
FSISPANIASFSLTH

LMTK2

1471

Q8IWU2
HQFSIKSFSSPTQCS

CDC42BPB

1026

Q9Y5S2
TPSSSSFHIQQLAGF

HCN4

851

Q9Y3Q4
NASFPSSFELSASSH

MFAP3

41

P55082
STLSNTTLQALHGFF

MEI1

1206

Q5TIA1
STSNPNSASLSSVFA

PROSER1

416

Q86XN7
FSDTLFSTLSSHQPV

MLXIP

281

Q9HAP2
LFSSSSAQSSNAPSA

PIKFYVE

1221

Q9Y2I7
FSSNHISPNSLLQSS

CHD9

276

Q3L8U1
FAQAQLHPSSSASFT

BICRAL

136

Q6AI39
LHPSSSASFTQASNV

BICRAL

141

Q6AI39
ANSSFFDNSSSPHLL

CENPF

266

P49454
KHPNFAFSVSSVNSL

IL23R

526

Q5VWK5
FHSSFESSASNTRAP

ANKS6

851

Q68DC2
LASASFSPNFTQVTS

MS4A6A

66

Q9H2W1
FTLQAHDQFSPFSSS

MCCC1

526

Q96RQ3
VPSSQSTASFLSHHS

CCDC158

876

Q5M9N0
LKVFNFNSSSTSHSS

CRYBG1

901

Q9Y4K1
TLQSLPSLNFNSFHS

ESRG

111

Q1W209
SSTGHSNRFASFLTT

GPR21

276

Q99679
LSFSHAPSFNFLSNS

FBXO30

381

Q8TB52
SNSLGFTATHNTSPA

RPRD2

626

Q5VT52
SFFTPDSNHNSLSQS

RPRD2

936

Q5VT52
VSSAFAFQNTFPHSI

SASS6

531

Q6UVJ0
AQSPFTHITTSDSFN

CREB3L2

91

Q70SY1
HFQPISNSIFNSSSN

LRRC19

241

Q9H756
LSNNHLTTVPASFSS

LRRC40

181

Q9H9A6
SGTISSASFHPQQFQ

PHYH

31

O14832
SPISADATHFSSNNS

RP1

606

P56715
STSNHTQFHPSSFLL

OR52E8

6

Q6IFG1
SNHSSDFPQLSSTNL

MEIOC

511

A2RUB1
DFGPSSQHFLSTSVQ

UTRN

2801

P46939
SFLPSANNSSSPHFR

DROSHA

191

Q9NRR4
LCSPTSHSSFNSSFT

NIN

2071

Q8N4C6
SHSSSFLSLTGFSLN

SMG7

926

Q92540
QLQTSSLPSASHFSQ

PRRC2C

2346

Q9Y520
SLSEFHQSSFLLSAS

SGO2

126

Q562F6
SSSRKHTPNFFSENS

SPAG4

11

Q9NPE6
NPDFSSLTHSAFSST

SP9

221

P0CG40
TGQFLAPNSHQSSSA

TFDP2

401

Q14188
PATLFNHFSSLFDSS

ANKHD1

2206

Q8IWZ3
NHFSSLFDSSQVPAN

ANKHD1

2211

Q8IWZ3
SDSPDSFISQSFHSF

CNBD1

221

Q8NA66
SFFQSISSDSLHSIN

ZCCHC2

456

Q9C0B9
FSTSASPLLSGSQHF

XPO1

386

O14980
NSPKHFPTANSSFAS

USP6NL

641

Q92738
FFSISPTSNSSATIA

STAU2

451

Q9NUL3
LASIYSPDHSSNNFS

TCF3

336

P15923
NVSNFTFAPSTIIFH

RPN2

566

P04844
STSFSHFDLPSSATF

SPATA31D1

936

Q6ZQQ2
FLAFTTHPSQFLRSS

XPO5

356

Q9HAV4
LFNTLNSHSSPFTAV

SLC7A13

326

Q8TCU3
RTFQSSLFSSGSFHS

nan

36

A1L4Q6
VTSLSSSSAHPFISN

ZNF839

101

A8K0R7
FSLHGFSNATQITSS

SLC39A8

81

Q9C0K1
SSALSSQRNSFPTSF

VGLL3

136

A8MV65
SFSRPFQSQNDHITF

TGM7

46

Q96PF1
DTSVLSHFAFNSASP

TBC1D19

326

Q8N5T2
LPEFTSIFSSHQTAA

KLF5

186

Q13887
ALSFGQESTTFHSNP

MUC12

1071

Q9UKN1
NLLHQLHPSTFSTFT

MXRA5

161

Q9NR99
NNSAHPSFFSSSSKG

MYO3B

1321

Q8WXR4
PSHFSDIFNFVSSTS

N4BP2

1281

Q86UW6