Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionantigen binding

IGKV1-17 LAG3 FCN3 IGKV1-5 FCGRT IGHV6-1 IGKV1D-12 TAP2

3.76e-06190968GO:0003823
GeneOntologyMolecularFunctionSUMO ligase activity

RGPD4 RGPD8 RGPD3

1.16e-0420963GO:0061665
GeneOntologyBiologicalProcessimmunoglobulin production

IGKV1-37 IGKV1-17 IGKV1-13 IGKV1-12 IGKV1-9 IGKV1-6 MZB1 IGKV1-5 IGKV1D-43 IGKV1D-42 IGKV1D-37 IGKV1D-17 IGKV1D-13 IGKV1D-12 IGKV1D-8

2.23e-1224110815GO:0002377
GeneOntologyBiologicalProcessproduction of molecular mediator of immune response

IGKV1-37 IGKV1-17 IGKV1-13 IGKV1-12 IGKV1-9 IGKV1-6 MZB1 IGKV1-5 IGKV1D-43 IGKV1D-42 IGKV1D-37 IGKV1D-17 IGKV1D-13 IGKV1D-12 IGKV1D-8

2.99e-0940310815GO:0002440
GeneOntologyBiologicalProcessadaptive immune response

IGKV1-37 IGKV1-17 IGKV1-13 IGKV1-12 IGKV1-9 IGKV1-6 LAG3 IGKV1-5 SCART1 IGKV1D-43 IGKV1D-42 IGKV1D-37 IGHV6-1 IGKV1D-17 IGKV1D-13 IGKV1D-12 IGKV1D-8 TAP2 IL27

6.58e-0883810819GO:0002250
GeneOntologyBiologicalProcessNLS-bearing protein import into nucleus

RGPD4 RGPD8 RGPD3 RGPD5

3.23e-06201084GO:0006607
GeneOntologyBiologicalProcesspositive regulation of glucokinase activity

RGPD4 RGPD8 RGPD3

1.15e-0591083GO:0033133
GeneOntologyBiologicalProcesspositive regulation of hexokinase activity

RGPD4 RGPD8 RGPD3

1.63e-05101083GO:1903301
GeneOntologyBiologicalProcessregulation of glucokinase activity

RGPD4 RGPD8 RGPD3

3.84e-05131083GO:0033131
GeneOntologyBiologicalProcessregulation of hexokinase activity

RGPD4 RGPD8 RGPD3

4.87e-05141083GO:1903299
GeneOntologyCellularComponentimmunoglobulin complex

IGKV1-37 IGKV1-17 IGKV1-13 IGKV1-12 IGKV1-9 IGKV1-6 IGKV1-5 IGKV1D-43 IGKV1D-42 IGKV1D-37 IGHV6-1 IGKV1D-17 IGKV1D-13 IGKV1D-12 IGKV1D-8

8.83e-1516610915GO:0019814
GeneOntologyCellularComponentcell surface

NID2 PRSS8 ADAM15 LAG3 FCN3 NFAM1 CHRNA4 KISS1R ANTXR2 PTPRK FCGRT LRPAP1 SCART1 LY6H SLC24A1 CTSZ IL17RB TREML2 IL27

4.38e-06111110919GO:0009986
GeneOntologyCellularComponentcytoplasmic periphery of the nuclear pore complex

RGPD4 RGPD8 RGPD3

7.58e-0681093GO:1990723
GeneOntologyCellularComponentnuclear pore cytoplasmic filaments

RGPD4 RGPD8 RGPD3

1.61e-05101093GO:0044614
GeneOntologyCellularComponentannulate lamellae

RGPD4 RGPD8 RGPD3

4.81e-05141093GO:0005642
GeneOntologyCellularComponentnuclear pore nuclear basket

RGPD4 RGPD8 RGPD3

1.06e-04181093GO:0044615
GeneOntologyCellularComponentnuclear inclusion body

RGPD4 RGPD8 RGPD3

1.47e-04201093GO:0042405
GeneOntologyCellularComponentSUMO ligase complex

RGPD4 RGPD8 RGPD3

1.71e-04211093GO:0106068
GeneOntologyCellularComponentendoplasmic reticulum lumen

MZB1 LAMB2 FOXRED2 SDF2L1 LRPAP1 CERCAM CTSZ IL27

3.52e-043321098GO:0005788
GeneOntologyCellularComponentnuclear pore

RGPD4 RGPD8 RGPD3 RGPD5

1.94e-031011094GO:0005643
GeneOntologyCellularComponentendoplasmic reticulum chaperone complex

MZB1 SDF2L1

2.02e-03131092GO:0034663
DomainGrip

RGPD4 RGPD8 RGPD3 RGPD5

1.93e-0711944SM00755
DomainGRIP

RGPD4 RGPD8 RGPD3 RGPD5

1.93e-0711944PF01465
DomainRan_BP1

RGPD4 RGPD8 RGPD3 RGPD5

2.89e-0712944PF00638
DomainGRIP_dom

RGPD4 RGPD8 RGPD3 RGPD5

2.89e-0712944IPR000237
DomainGRIP

RGPD4 RGPD8 RGPD3 RGPD5

2.89e-0712944PS50913
DomainRANBD1

RGPD4 RGPD8 RGPD3 RGPD5

2.89e-0712944PS50196
DomainRanBD

RGPD4 RGPD8 RGPD3 RGPD5

4.15e-0713944SM00160
DomainRan_bind_dom

RGPD4 RGPD8 RGPD3 RGPD5

4.15e-0713944IPR000156
DomainER_TARGET

MZB1 FOXRED2 SDF2L1 LRPAP1 CERCAM

3.76e-0647945PS00014
DomainGCC2_Rab_bind

RGPD4 RGPD8 RGPD3

4.26e-067943IPR032023
DomainRab_bind

RGPD4 RGPD8 RGPD3

4.26e-067943PF16704
Domain-

RGPD4 RGPD8 RGPD3

1.44e-05109431.10.220.60
DomainIG_LIKE

LAG3 SIGLEC14 SIGLEC5 LRRC4B NFAM1 IGKV1-5 PTPRK FCGRT SCN4B TREML2

1.81e-044919410PS50835
DomainIg-like_dom

LAG3 SIGLEC14 SIGLEC5 LRRC4B NFAM1 IGKV1-5 PTPRK FCGRT SCN4B TREML2

2.19e-045039410IPR007110
DomainV-set

LAG3 SIGLEC14 SIGLEC5 IGKV1-5 SCN4B TREML2

3.35e-04184946PF07686
DomainIg_V-set

LAG3 SIGLEC14 SIGLEC5 IGKV1-5 SCN4B TREML2

5.07e-04199946IPR013106
DomainDUF3456

MZB1 CRELD1

5.18e-047942PF11938
DomainDUF3456

MZB1 CRELD1

5.18e-047942IPR021852
DomainTPR-contain_dom

RGPD4 RGPD8 TOMM70 RGPD3 RGPD5

9.66e-04150945IPR013026
DomainIG

LAG3 SIGLEC14 SIGLEC5 LRRC4B NFAM1 PTPRK SCN4B TREML2

1.28e-03421948SM00409
DomainIg_sub

LAG3 SIGLEC14 SIGLEC5 LRRC4B NFAM1 PTPRK SCN4B TREML2

1.28e-03421948IPR003599
DomainGalactose-bd-like

GLB1L3 LAMB2 PTPRK CPXM1

1.30e-0394944IPR008979
DomainTPR_REGION

RGPD4 RGPD8 TOMM70 RGPD3 RGPD5

1.48e-03165945PS50293
DomainTPR

RGPD4 RGPD8 TOMM70 RGPD3 RGPD5

1.48e-03165945PS50005
DomainSushi

SEZ6L2 SUSD5 SUSD2

2.28e-0352943PF00084
DomainCCP

SEZ6L2 SUSD5 SUSD2

2.54e-0354943SM00032
DomainSUSHI

SEZ6L2 SUSD5 SUSD2

2.82e-0356943PS50923
DomainIg-like_fold

LAG3 SIGLEC14 SIGLEC5 LRRC4B NFAM1 IGKV1-5 PTPRK FCGRT SCN4B TREML2

2.90e-037069410IPR013783
DomainSushi_SCR_CCP_dom

SEZ6L2 SUSD5 SUSD2

2.97e-0357943IPR000436
DomainIg/MHC_CS

SIGLEC14 SIGLEC5 FCGRT

3.12e-0358943IPR003006
DomainIG_MHC

SIGLEC14 SIGLEC5 FCGRT

3.43e-0360943PS00290
DomainADAM_CR

ADAM15 ADAM33

3.64e-0318942PF08516
DomainTPR

RGPD4 RGPD8 TOMM70 RGPD3

4.10e-03129944SM00028
Domain-

ADAM15 ADAM33

4.49e-03209424.10.70.10
DomainTPR_repeat

RGPD4 RGPD8 TOMM70 RGPD3

4.57e-03133944IPR019734
DomainDisintegrin

ADAM15 ADAM33

4.95e-0321942PF00200
DomainDISIN

ADAM15 ADAM33

4.95e-0321942SM00050
DomainFGF

FGF3 FGF4

5.42e-0322942SM00442
DomainFGF

FGF3 FGF4

5.42e-0322942PF00167
DomainHBGF_FGF

FGF3 FGF4

5.42e-0322942PS00247
DomainFibroblast_GF_fam

FGF3 FGF4

5.42e-0322942IPR002209
DomainIL-1_fam/FGF_fam

FGF3 FGF4

5.92e-0323942IPR028142
DomainABC_membrane

TAP2 ABCC10

6.44e-0324942PF00664
DomainTPR-like_helical_dom

RGPD4 RGPD8 TOMM70 RGPD3 RGPD5

6.47e-03233945IPR011990
DomainEGF

NID2 ADAM15 LAMB2 CRELD1 ADAM33

6.70e-03235945SM00181
PathwayREACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS

IGKV1-17 IGKV1-12 FCN3 IGKV1-5 IGKV1D-12

3.23e-0571735M1078
PathwayREACTOME_INITIAL_TRIGGERING_OF_COMPLEMENT

IGKV1-17 IGKV1-12 FCN3 IGKV1-5 IGKV1D-12

5.76e-0580735M6121
PathwayBIOCARTA_RANBP2_PATHWAY

RGPD4 RGPD8 RGPD3

1.03e-0418733MM1549
PathwayREACTOME_CD22_MEDIATED_BCR_REGULATION

IGKV1-17 IGKV1-12 IGKV1-5 IGKV1D-12

2.76e-0461734M27581
PathwayREACTOME_COMPLEMENT_CASCADE

IGKV1-17 IGKV1-12 FCN3 IGKV1-5 IGKV1D-12

3.20e-04115735M19752
PathwayREACTOME_FCGR_ACTIVATION

IGKV1-17 IGKV1-12 IGKV1-5 IGKV1D-12

4.44e-0469734M27108
PathwayREACTOME_SCAVENGING_OF_HEME_FROM_PLASMA

IGKV1-17 IGKV1-12 IGKV1-5 IGKV1D-12

4.44e-0469734M27150
PathwayREACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL

IGKV1-17 IGKV1-12 SIGLEC5 IGKV1-5 IGKV1D-12 TREML2

4.46e-04190736M8240
PathwayREACTOME_ROLE_OF_LAT2_NTAL_LAB_ON_CALCIUM_MOBILIZATION

IGKV1-17 IGKV1-12 IGKV1-5 IGKV1D-12

4.95e-0471734M27203
Pubmed

Characteristics of the immunoglobulin Vkappa genes, pseudogenes, relics and orphons in the mouse genome.

IGKV1-17 IGKV1-13 IGKV1-9 IGKV1-6 IGKV1-5 IGKV1D-43 IGKV1D-17 IGKV1D-13 IGKV1D-8

4.37e-1820112910427970
Pubmed

Human myeloperoxidase in innate and acquired immunity.

IGKV1-13 IGKV1-12 IGKV1-9 IGKV1-5 IGKV1D-43 IGKV1D-13 IGKV1D-12 IGKV1D-8

3.82e-1618112820399194
Pubmed

The V kappa genes of the L regions and the repertoire of V kappa gene sequences in the human germ line.

IGKV1-17 IGKV1-12 IGKV1D-43 IGKV1D-42 IGKV1D-17 IGKV1D-13 IGKV1D-12

5.62e-141711278223863
Pubmed

Variation in the crossover point of kappa immunoglobulin gene V-J recombination: evidence from a cryptic gene.

IGKV1-17 IGKV1-13 IGKV1-6 IGKV1-5 IGKV1D-17 IGKV1D-13

8.12e-14911266777049
Pubmed

Amino acid sequence of the variable region of M149 mouse myeloma light chain: comparison with the nucleotide sequence of K2 and K3 clones.

IGKV1-13 IGKV1-9 IGKV1-5 IGKV1D-43 IGKV1D-13 IGKV1D-8

4.44e-131111266795447
Pubmed

Multiple related immunoglobulin variable-region genes identified by cloning and sequence analysis.

IGKV1-13 IGKV1-9 IGKV1-5 IGKV1D-43 IGKV1D-13 IGKV1D-8

4.44e-13111126279004
Pubmed

Organization and complete sequence of identical embryonic and plasmacytoma kappa V-region genes.

IGKV1-13 IGKV1-9 IGKV1-5 IGKV1D-43 IGKV1D-13 IGKV1D-8

4.44e-131111266767723
Pubmed

Structure and implied functions of truncated B-cell receptor mRNAs in early embryo and adult mesenchymal stem cells: Cdelta replaces Cmu in mu heavy chain-deficient mice.

IGKV1-17 IGKV1-13 IGKV1-6 IGKV1-5 IGKV1D-17 IGKV1D-13

7.60e-1216112617124007
Pubmed

Evolutionary dynamics of the human immunoglobulin kappa locus and the germline repertoire of the Vkappa genes.

IGKV1D-43 IGKV1D-42 IGKV1D-37 IGKV1D-17 IGKV1D-13 IGKV1D-12 IGKV1D-8

2.29e-1136112711298326
Pubmed

Complex genomic rearrangements lead to novel primate gene function.

RGPD4 RGPD8 RGPD3 RGPD5

3.54e-097112415710750
Pubmed

Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.

NRM OSTM1 ADAM15 GPRC5C HTRA4 FCN3 SEZ6L2 CLDN2 TOMM70 PIGT FCGRT APCDD1L

1.59e-084301121216303743
Pubmed

The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

C1QTNF8 OSTM1 TMEM41A SIGLEC14 FCN3 SEZ6L2 CLDN2 CRELD1 PIGT PPT2 CPXM1 SDF2L1 ADAM33 MOGAT3 XKR5 IL17RB TREML2

1.83e-089851121712975309
Pubmed

ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.

NRM ADAM15 KIAA1549 LAMB2 SEZ6L2 CRELD1 THADA PIGT FOXRED2 PTPRK TMEM245 LRPAP1 CERCAM LTBR CERS1 TAP2 CTSZ ATP6V0A2

5.68e-0812011121835696571
Pubmed

IMGT/GENE-DB: a comprehensive database for human and mouse immunoglobulin and T cell receptor genes.

IGKV1-17 IGKV1-13 IGKV1-6 IGKV1-5 IGKV1D-17 IGKV1D-13

1.92e-0777112615608191
Pubmed

Organization and evolution of a gene cluster for human immunoglobulin variable regions of the kappa type.

IGKV1-13 IGKV1-12 IGKV1-9

3.24e-07511236086934
Pubmed

Nup358, a nucleoporin, functions as a key determinant of the nuclear pore complex structure remodeling during skeletal myogenesis.

RGPD4 RGPD8 RGPD3

1.13e-067112321205196
Pubmed

Haploinsufficiency of RanBP2 is neuroprotective against light-elicited and age-dependent degeneration of photoreceptor neurons.

RGPD4 RGPD8 RGPD3

1.13e-067112318949001
Pubmed

Selective impairment of a subset of Ran-GTP-binding domains of ran-binding protein 2 (Ranbp2) suffices to recapitulate the degeneration of the retinal pigment epithelium (RPE) triggered by Ranbp2 ablation.

RGPD4 RGPD8 RGPD3

1.13e-067112325187515
Pubmed

Interconversion of red opsin isoforms by the cyclophilin-related chaperone protein Ran-binding protein 2.

RGPD4 RGPD8 RGPD3

1.13e-06711239037092
Pubmed

Localization of the Ran-GTP binding protein RanBP2 at the cytoplasmic side of the nuclear pore complex.

RGPD4 RGPD8 RGPD3

1.13e-06711238603673
Pubmed

Uncoupling phototoxicity-elicited neural dysmorphology and death by insidious function and selective impairment of Ran-binding protein 2 (Ranbp2).

RGPD4 RGPD8 RGPD3

1.13e-067112326632511
Pubmed

Differential loss of prolyl isomerase or chaperone activity of Ran-binding protein 2 (Ranbp2) unveils distinct physiological roles of its cyclophilin domain in proteostasis.

RGPD4 RGPD8 RGPD3

1.13e-067112324403063
Pubmed

Distinct and atypical intrinsic and extrinsic cell death pathways between photoreceptor cell types upon specific ablation of Ranbp2 in cone photoreceptors.

RGPD4 RGPD8 RGPD3

1.13e-067112323818861
Pubmed

Genomic organization, expression, and localization of murine Ran-binding protein 2 (RanBP2) gene.

RGPD4 RGPD8 RGPD3

1.13e-067112311353387
Pubmed

Microglial activation in an amyotrophic lateral sclerosis-like model caused by Ranbp2 loss and nucleocytoplasmic transport impairment in retinal ganglion neurons.

RGPD4 RGPD8 RGPD3

1.13e-067112330944974
Pubmed

Nucleoporin Nup358 drives the differentiation of myeloid-biased multipotent progenitors by modulating HDAC3 nuclear translocation.

RGPD4 RGPD8 RGPD3

1.13e-067112338838144
Pubmed

Kinesin-1 and mitochondrial motility control by discrimination of structurally equivalent but distinct subdomains in Ran-GTP-binding domains of Ran-binding protein 2.

RGPD4 RGPD8 RGPD3

1.13e-067112323536549
Pubmed

Retina-specifically expressed novel subtypes of bovine cyclophilin.

RGPD4 RGPD8 RGPD3

1.13e-06711237559465
Pubmed

Mst1, RanBP2 and eIF4G are new markers for in vivo PI3K activation in murine and human prostate.

RGPD4 RGPD8 RGPD3

1.13e-067112317372272
Pubmed

Proteostatic Remodeling of Small Heat Shock Chaperones─Crystallins by Ran-Binding Protein 2─and the Peptidyl-Prolyl cis-trans Isomerase and Chaperone Activities of Its Cyclophilin Domain.

RGPD4 RGPD8 RGPD3

1.13e-067112338657106
Pubmed

Identification of RanBP2- and kinesin-mediated transport pathways with restricted neuronal and subcellular localization.

RGPD4 RGPD8 RGPD3

1.13e-067112312191015
Pubmed

Ranbp2 haploinsufficiency mediates distinct cellular and biochemical phenotypes in brain and retinal dopaminergic and glia cells elicited by the Parkinsonian neurotoxin, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).

RGPD4 RGPD8 RGPD3

1.13e-067112322821000
Pubmed

Neuroprotection resulting from insufficiency of RANBP2 is associated with the modulation of protein and lipid homeostasis of functionally diverse but linked pathways in response to oxidative stress.

RGPD4 RGPD8 RGPD3

1.13e-067112320682751
Pubmed

The distribution of phosphorylated SR proteins and alternative splicing are regulated by RANBP2.

RGPD4 RGPD8 RGPD3

1.80e-068112322262462
Pubmed

The nucleoporin RanBP2 tethers the cAMP effector Epac1 and inhibits its catalytic activity.

RGPD4 RGPD8 RGPD3

1.80e-068112321670213
Pubmed

Zap70 and downstream RanBP2 are required for the exact timing of the meiotic cell cycle in oocytes.

RGPD4 RGPD8 RGPD3

1.80e-068112328745977
Pubmed

Critical role of RanBP2-mediated SUMOylation of Small Heterodimer Partner in maintaining bile acid homeostasis.

RGPD4 RGPD8 RGPD3

1.80e-068112327412403
Pubmed

Mice lacking Ran binding protein 1 are viable and show male infertility.

RGPD4 RGPD8 RGPD3

1.80e-068112321310149
Pubmed

Resolution of sister centromeres requires RanBP2-mediated SUMOylation of topoisomerase IIalpha.

RGPD4 RGPD8 RGPD3

2.69e-069112318394993
Pubmed

The docking of kinesins, KIF5B and KIF5C, to Ran-binding protein 2 (RanBP2) is mediated via a novel RanBP2 domain.

RGPD4 RGPD8 RGPD3

2.69e-069112311553612
Pubmed

The zinc finger cluster domain of RanBP2 is a specific docking site for the nuclear export factor, exportin-1.

RGPD4 RGPD8 RGPD3

2.69e-069112310601307
Pubmed

The cyclophilin-like domain mediates the association of Ran-binding protein 2 with subunits of the 19 S regulatory complex of the proteasome.

RGPD4 RGPD8 RGPD3

2.69e-06911239733766
Pubmed

Loss of Ranbp2 in motoneurons causes disruption of nucleocytoplasmic and chemokine signaling, proteostasis of hnRNPH3 and Mmp28, and development of amyotrophic lateral sclerosis-like syndromes.

RGPD4 RGPD8 RGPD3

2.69e-069112328100513
Pubmed

Impairments in age-dependent ubiquitin proteostasis and structural integrity of selective neurons by uncoupling Ran GTPase from the Ran-binding domain 3 of Ranbp2 and identification of novel mitochondrial isoforms of ubiquitin-conjugating enzyme E2I (ubc9) and Ranbp2.

RGPD4 RGPD8 RGPD3

2.69e-069112328877029
Pubmed

Association of the kinesin-binding domain of RanBP2 to KIF5B and KIF5C determines mitochondria localization and function.

RGPD4 RGPD8 RGPD3

2.69e-069112317887960
Pubmed

Regulation of feto-maternal barrier by matriptase- and PAR-2-mediated signaling is required for placental morphogenesis and mouse embryonic survival.

PRSS8 ERVW-1 CLDN2

3.84e-0610112325078604
Pubmed

Cyclophilin-related protein RanBP2 acts as chaperone for red/green opsin.

RGPD4 RGPD8 RGPD3

3.84e-061011238857542
Pubmed

The RanBP2/RanGAP1*SUMO1/Ubc9 SUMO E3 ligase is a disassembly machine for Crm1-dependent nuclear export complexes.

RGPD4 RGPD8 RGPD3

3.84e-0610112327160050
Pubmed

Parkin ubiquitinates and promotes the degradation of RanBP2.

RGPD4 RGPD8 RGPD3

3.84e-0610112316332688
Pubmed

Ran-dependent docking of importin-beta to RanBP2/Nup358 filaments is essential for protein import and cell viability.

RGPD4 RGPD8 RGPD3

3.84e-0610112321859863
Pubmed

An Rtn4/Nogo-A-interacting micropeptide modulates synaptic plasticity with age.

RGPD4 RGPD8 RGPD3

5.26e-0611112335771867
Pubmed

RanBP2 modulates Cox11 and hexokinase I activities and haploinsufficiency of RanBP2 causes deficits in glucose metabolism.

RGPD4 RGPD8 RGPD3

5.26e-0611112317069463
Pubmed

T-cell receptor (TCR) signaling promotes the assembly of RanBP2/RanGAP1-SUMO1/Ubc9 nuclear pore subcomplex via PKC-θ-mediated phosphorylation of RanGAP1.

RGPD4 RGPD8 RGPD3

5.26e-0611112334110283
Pubmed

Ankyrin-G induces nucleoporin Nup358 to associate with the axon initial segment of neurons.

RGPD4 RGPD8 RGPD3

9.08e-0613112331427429
Pubmed

Differential expression of two homologous and clustered oncogenes, Hst1 and Int-2, during differentiation of F9 cells.

FGF3 FGF4

1.03e-05211223060118
Pubmed

Siglec-5 and Siglec-14 are polymorphic paired receptors that modulate neutrophil and amnion signaling responses to group B Streptococcus.

SIGLEC14 SIGLEC5

1.03e-052112224799499
Pubmed

Functional and non-functional joining in immunoglobulin light chain genes of a mouse myeloma.

IGKV1-12 IGKV1D-12

1.03e-05211226776411
Pubmed

Variable region sequences of autoantibodies from mice with experimental systemic lupus erythematosus.

IGKV1-12 IGKV1D-12

1.03e-05211228325334
Pubmed

Loads, capacities and safety factors of maltase and the glucose transporter SGLT1 in mouse intestinal brush border.

MGAM SLC5A1

1.03e-052112212122147
Pubmed

Crouzon-like craniofacial dysmorphology in the mouse is caused by an insertional mutation at the Fgf3/Fgf4 locus.

FGF3 FGF4

1.03e-05211229626498
Pubmed

The mouse homologue of hst/k-FGF: sequence, genome organization and location relative to int-2.

FGF3 FGF4

1.03e-05211222740210
Pubmed

Cloning and characterization of 1116NS19.9 heavy and light chain cDNAs and expression of antibody fragments in Escherichia coli.

IGKV1-12 IGKV1D-12

1.03e-05211228372513
Pubmed

Increased FGF3 and FGF4 gene dosage is a risk factor for craniosynostosis.

FGF3 FGF4

1.03e-052112224120895
Pubmed

Immunomodulatory activity of extracellular Hsp70 mediated via paired receptors Siglec-5 and Siglec-14.

SIGLEC14 SIGLEC5

1.03e-052112226459514
Pubmed

The mouse homolog of the hst/k-FGF gene is adjacent to int-2 and is activated by proviral insertion in some virally induced mammary tumors.

FGF3 FGF4

1.03e-05211222548184
Pubmed

Limited expression of nuclear pore membrane glycoprotein 210 in cell lines and tissues suggests cell-type specific nuclear pores in metazoans.

RGPD4 RGPD8 RGPD3

1.44e-0515112314697343
Pubmed

A mouse knockout library for secreted and transmembrane proteins.

OSTM1 SIGLEC14 SIGLEC5 SEZ6L2 CLDN2 CRELD1 PIGT ADAM33 TREML2

1.89e-05460112920562862
Pubmed

Small intestinal resident eosinophils maintain gut homeostasis following microbial colonization.

SIGLEC14 SIGLEC5 IL17RB

2.14e-0517112335709757
Pubmed

Siglec-F-dependent negative regulation of allergen-induced eosinophilia depends critically on the experimental model.

SIGLEC14 SIGLEC5

3.08e-053112224698729
Pubmed

High expression of Claudin-2 in esophageal carcinoma and precancerous lesions is significantly associated with the bile salt receptors VDR and TGR5.

GPBAR1 CLDN2

3.08e-053112228212604
Pubmed

Cloning and characterization of a novel mouse Siglec, mSiglec-F: differential evolution of the mouse and human (CD33) Siglec-3-related gene clusters.

SIGLEC14 SIGLEC5

3.08e-053112211579105
Pubmed

Discovery of Siglec-14, a novel sialic acid receptor undergoing concerted evolution with Siglec-5 in primates.

SIGLEC14 SIGLEC5

3.08e-053112217012248
Pubmed

Siglec-F is induced by granulocyte-macrophage colony-stimulating factor and enhances interleukin-4-induced expression of arginase-1 in mouse macrophages.

SIGLEC14 SIGLEC5

3.08e-053112231520477
Pubmed

Antiallergic effect of anti-Siglec-F through reduction of eosinophilic inflammation in murine allergic rhinitis.

SIGLEC14 SIGLEC5

3.08e-053112223710953
Pubmed

Anti-Siglec-F antibody reduces allergen-induced eosinophilic inflammation and airway remodeling.

SIGLEC14 SIGLEC5

3.08e-053112219783675
Pubmed

Mast Cell-Specific Expression of Human Siglec-8 in Conditional Knock-in Mice.

SIGLEC14 SIGLEC5

3.08e-053112230577572
Pubmed

A novel Siglec-F+ neutrophil subset in the mouse nasal mucosa exhibits an activated phenotype and is increased in an allergic rhinitis model.

SIGLEC14 SIGLEC5

3.08e-053112232247614
Pubmed

An IL-27/Lag3 axis enhances Foxp3+ regulatory T cell-suppressive function and therapeutic efficacy.

LAG3 IL27

3.08e-053112226013006
Pubmed

Mouse mammary tumor virus infection accelerates mammary carcinogenesis in Wnt-1 transgenic mice by insertional activation of int-2/Fgf-3 and hst/Fgf-4.

FGF3 FGF4

3.08e-05311228380647
Pubmed

Frontline Science: Superior mouse eosinophil depletion in vivo targeting transgenic Siglec-8 instead of endogenous Siglec-F: Mechanisms and pitfalls.

SIGLEC14 SIGLEC5

3.08e-053112232134149
Pubmed

Endogenous airway mucins carry glycans that bind Siglec-F and induce eosinophil apoptosis.

SIGLEC14 SIGLEC5

3.08e-053112225497369
Pubmed

Siglec-F is a novel intestinal M cell marker.

SIGLEC14 SIGLEC5

3.08e-053112227524237
Pubmed

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.

IGKV1-17 NID2 MGAM PRSS8 SHBG LAMB2 GPRC5C LCAT IGKV1-5 PPT2 SUSD2 IGKV1D-12 CTSZ

4.19e-0510701121323533145
Pubmed

Terminal differentiation of cortical neurons rapidly remodels RanGAP-mediated nuclear transport system.

RGPD4 RGPD8 RGPD3

4.79e-0522112327717094
Pubmed

Fgf3-Fgf4-cis: A new mouse line for studying Fgf functions during mouse development.

FGF3 FGF4

6.14e-054112226666435
Pubmed

Distinct endocytic mechanisms of CD22 (Siglec-2) and Siglec-F reflect roles in cell signaling and innate immunity.

SIGLEC14 SIGLEC5

6.14e-054112217562860
Pubmed

Defining the in vivo function of Siglec-F, a CD33-related Siglec expressed on mouse eosinophils.

SIGLEC14 SIGLEC5

6.14e-054112217272508
Pubmed

Differences between germ-line and rearranged immunoglobulin V kappa coding sequences suggest a localized mutation mechanism.

IGKV1-12 IGKV1D-12

6.14e-05411226264318
Pubmed

Phosphoproteomics identifies microglial Siglec-F inflammatory response during neurodegeneration.

SIGLEC14 SIGLEC5

6.14e-054112233289969
Pubmed

IgG-assisted age-dependent clearance of Alzheimer's amyloid beta peptide by the blood-brain barrier neonatal Fc receptor.

FCGRT LRPAP1

6.14e-054112216354907
Pubmed

New gene in the homologous human 11q13-q14 and mouse 7F chromosomal regions.

FGF3 FGF4

6.14e-05411221543912
Pubmed

IL-17 mediates protective immunity against nasal infection with Bordetella pertussis by mobilizing neutrophils, especially Siglec-F+ neutrophils.

SIGLEC14 SIGLEC5

6.14e-054112233976385
Pubmed

Composite human VK genes and a model of their evolution.

IGKV1-5 IGKV1D-8

6.14e-05411226087279
Pubmed

A large section of the gene locus encoding human immunoglobulin variable regions of the kappa type is duplicated.

IGKV1D-13 IGKV1D-12

6.14e-05411223927006
Pubmed

Cross-species comparison of 5-lipoxygenase-activating protein.

FGF3 FGF4

6.14e-05411221480129
Pubmed

Siglec-8 on human eosinophils and mast cells, and Siglec-F on murine eosinophils, are functionally related inhibitory receptors.

SIGLEC14 SIGLEC5

6.14e-054112219178537
Pubmed

Murine FGF-4 gene expression is spatially restricted within embryonic skeletal muscle and other tissues.

FGF3 FGF4

6.14e-05411227684245
Pubmed

Induction of Siglec-FhiCD101hi eosinophils in the lungs following murine hookworm Nippostrongylus brasiliensis infection.

SIGLEC14 SIGLEC5

6.14e-054112237251384
Pubmed

Expression and function of FGF-4 in peri-implantation development in mouse embryos.

FGF3 FGF4

6.14e-05411227925026
Pubmed

Identification of a novel Ran binding protein 2 related gene (RANBP2L1) and detection of a gene cluster on human chromosome 2q11-q12.

RGPD8 RGPD5

6.14e-05411229480752
InteractionLGALS8 interactions

OSTM1 KIAA1549 LRRC4B SEZ6L2 PTPRK SUSD5 CTSZ ATP6V0A2

2.31e-06174998int:LGALS8
InteractionRGPD4 interactions

RGPD4 RGPD8 RGPD3 RGPD5

3.74e-0622994int:RGPD4
InteractionSDF2L1 interactions

ADAM15 LAMB2 SEZ6L2 PIGT FOXRED2 SUSD2 SDF2L1 LRPAP1 CERCAM ADAM33

4.18e-063229910int:SDF2L1
InteractionFBXO2 interactions

NID2 OSTM1 INSL3 LAG3 LAMB2 SEZ6L2 PIGT PPT2 PTPRK ADAM33 CTSZ

5.60e-064119911int:FBXO2
InteractionRGPD2 interactions

RGPD4 RGPD8 RGPD3 RGPD5

8.82e-0627994int:RGPD2
InteractionMANEA interactions

TTYH1 NID2 LAMB2 CHRNA4 CRELD1

1.14e-0560995int:MANEA
InteractionMIA2 interactions

TTYH1 RGPD8 GPRC5C RGPD3 SDF2L1 RGPD5

1.99e-05113996int:MIA2
InteractionCDHR4 interactions

LAMB2 SEZ6L2 PTPRK SDF2L1 CERCAM

2.11e-0568995int:CDHR4
InteractionTMEM39B interactions

TTYH1 CHRNA4 CRELD1 ADAM33

3.95e-0539994int:TMEM39B
InteractionADAM33 interactions

ADAM15 CLDN2 PIGT SDF2L1 ADAM33

4.37e-0579995int:ADAM33
InteractionGPAA1 interactions

TTYH1 PRSS8 KCNK16 CRELD1 PIGT

7.33e-0588995int:GPAA1
InteractionRGPD3 interactions

RGPD4 RGPD8 RGPD3 RGPD5

8.31e-0547994int:RGPD3
InteractionRGPD1 interactions

RGPD4 RGPD8 RGPD3 RGPD5

9.80e-0549994int:RGPD1
InteractionLY86 interactions

NID2 RGPD8 LAMB2 FOXRED2 PTPRK SDF2L1 CERCAM

9.80e-05217997int:LY86
InteractionLGALS1 interactions

NID2 KIAA1549 LRRC4B SEZ6L2 PTPRK SUSD5 SUSD2 ATP6V0A2

2.32e-04332998int:LGALS1
InteractionTCTN3 interactions

TMEM41A PIGT TMEM245 LRPAP1 CERS1 TAP2 MFSD10 ATP6V0A2

2.42e-04334998int:TCTN3
InteractionDRD2 interactions

TTYH1 ADGRB1 CRELD1 CERS1 ATP6V0A2

2.48e-04114995int:DRD2
Cytoband2p12

IGKV1-37 IGKV1-17 IGKV1-13 IGKV1-12 IGKV1-9 IGKV1-6 IGKV1-5 IGKV1D-43 IGKV1D-42 IGKV1D-37 IGKV1D-17 IGKV1D-13 IGKV1D-12 IGKV1D-8

4.25e-20117112142p12
CytobandEnsembl 112 genes in cytogenetic band chr2p11

IGKV1-37 IGKV1-17 IGKV1-13 IGKV1-12 IGKV1-9 IGKV1-6 IGKV1-5 IGKV1D-43 IGKV1D-42 IGKV1D-37 IGKV1D-17 IGKV1D-13 IGKV1D-12 IGKV1D-8

2.24e-1621311214chr2p11
Cytoband8q24.3

ADGRB1 WDR97 LY6H MFSD3

1.76e-0411311248q24.3
Cytoband2q13

RGPD8 RGPD3 RGPD5

6.31e-046811232q13
Cytoband19q13.4

TTYH1 SIGLEC14 ACP4

9.77e-0479112319q13.4
Cytoband20q13.32

APCDD1L CTSZ

1.09e-0320112220q13.32
CytobandEnsembl 112 genes in cytogenetic band chr6p21

NRM KCNK16 PPT2 TAP2 ABCC10 TREML2

1.51e-035031126chr6p21
Cytoband22q12.3

SLC5A1 FOXRED2

2.96e-0333112222q12.3
CytobandEnsembl 112 genes in cytogenetic band chr20q13

C20orf204 CHRNA4 PIGT APCDD1L CTSZ

3.85e-034221125chr20q13
GeneFamilyImmunoglobulin kappa locus at 2p11.2

IGKV1-37 IGKV1-17 IGKV1-13 IGKV1-12 IGKV1-9 IGKV1-6 IGKV1-5 IGKV1D-43 IGKV1D-42 IGKV1D-37 IGKV1D-17 IGKV1D-13 IGKV1D-12 IGKV1D-8

3.90e-19837714351
GeneFamilyTetratricopeptide repeat domain containing|Bardet-Biedl syndrome associated|BBSome

RGPD4 RGPD8 TOMM70 RGPD3 RGPD5

1.31e-04115775769
GeneFamilyHyalectan proteoglycans|V-set domain containing|Sushi domain containing|C-type lectin domain containing

SEZ6L2 SUSD5 SUSD2

1.84e-03577731179
GeneFamilyProtein tyrosine phosphatases, receptor type

PTPRE PTPRK

3.57e-0321772813
GeneFamilyAdenosine receptors|V-set domain containing

SIGLEC14 SIGLEC5 SCN4B TREML2

5.17e-03163774590
GeneFamilyADAM metallopeptidase domain containing|CD molecules

ADAM15 ADAM33

5.87e-032777247
GeneFamilyCD molecules|C2-set domain containing|Sialic acid binding Ig like lectins

SIGLEC14 SIGLEC5

6.30e-0328772745
CoexpressionRASHI_RESPONSE_TO_IONIZING_RADIATION_6

IGKV1-13 IGKV1-12 IGKV1-9 IGKV1-5 IGKV1D-43 IGKV1D-13 IGKV1D-12 IGKV1D-8

8.28e-081321098MM996
CoexpressionAtlasDevelopingKidney_e15.5_early proxim tubul_emap-28005_top-relative-expression-ranked_1000

MGAM PRSS8 GPRC5C CLDN2 SLC5A1 TMEM256 MTMR11 FADS3 PPT2 FCGRT SUSD2 LRPAP1 ABCC10 MFSD3

1.62e-057849914gudmap_developingKidney_e15.5_early proxim tubul_1000
ToppCellParenchymal-10x5prime-Immune_Lymphocytic-B-B_plasma|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

IGKV1-37 IGKV1-17 IGKV1-13 IGKV1-12 IGKV1-9 IGKV1-6 MZB1 IGKV1-5 IGKV1D-43 IGKV1D-37 IGHV6-1 IGKV1D-17 IGKV1D-13 IGKV1D-12 IGKV1D-8

1.81e-18194111156ef4aeb8d8e35e4df58ff2a8256caa2113291de9
ToppCellParenchymal-10x5prime-Immune_Lymphocytic-B-B_plasma-B_plasma_IgG|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

IGKV1-37 IGKV1-17 IGKV1-13 IGKV1-12 IGKV1-9 IGKV1-6 MZB1 IGKV1-5 IGKV1D-43 IGKV1D-37 IGHV6-1 IGKV1D-17 IGKV1D-13 IGKV1D-12 IGKV1D-8

1.96e-1819511115f3f7f1a77a1edd2b50a8211c76fe289738eb04cf
ToppCellBiopsy_IPF-Immune-Plasma_cells|Biopsy_IPF / Sample group, Lineage and Cell type

IGKV1-37 IGKV1-17 IGKV1-13 IGKV1-12 IGKV1-9 IGKV1-6 MZB1 IGKV1-5 KISS1R SDF2L1 IGKV1D-43 IGHV6-1 IGKV1D-17 IGKV1D-13 IGKV1D-8

2.11e-1819611115a1b6a8000b86efcb07843998aa3a49bb1f54bcda
ToppCellIPF-Lymphoid-B_Plasma|IPF / Disease state, Lineage and Cell class

IGKV1-37 IGKV1-17 IGKV1-13 IGKV1-12 IGKV1-6 MZB1 IGKV1-5 IGKV1D-43 IGHV6-1 IGKV1D-17 IGKV1D-13 IGKV1D-12 IGKV1D-8

6.90e-1617611113e4f33f6cd140dd4fa3002bcd65ac8005d27865d1
ToppCell5'-Adult-LargeIntestine-Hematopoietic-Plasma_cells|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

IGKV1-17 IGKV1-12 IGKV1-9 IGKV1-6 MZB1 IGKV1-5 SDF2L1 IGKV1D-43 IGHV6-1 IGKV1D-17 IGKV1D-13 IGKV1D-12 IGKV1D-8

1.88e-151901111379ee6d10dfbb775da149a1104da5823cf63bbb46
ToppCell5'-Adult-LargeIntestine-Hematopoietic-Plasma_cells-IgA_plasma_cell|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

IGKV1-17 IGKV1-12 IGKV1-9 IGKV1-6 MZB1 IGKV1-5 SDF2L1 IGKV1D-43 IGHV6-1 IGKV1D-17 IGKV1D-13 IGKV1D-12 IGKV1D-8

1.88e-151901111318762ce78ed0b206ade19e1c8ff76a2647489f68
ToppCellParenchymal-10x5prime-Immune_Lymphocytic-B-B_plasma-B_plasma_IgA|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

IGKV1-17 IGKV1-13 IGKV1-12 IGKV1-9 IGKV1-6 MZB1 IGKV1-5 IGKV1D-43 IGHV6-1 IGKV1D-17 IGKV1D-13 IGKV1D-12 IGKV1D-8

2.30e-151931111334f6c13884fdf7f8a87f942fcb36a58cfac3f65d
ToppCellParenchymal-10x5prime-Immune_Lymphocytic-B|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

IGKV1-17 IGKV1-13 IGKV1-12 IGKV1-9 IGKV1-6 MZB1 IGKV1-5 IGKV1D-43 IGHV6-1 IGKV1D-17 IGKV1D-13 IGKV1D-12 IGKV1D-8

3.01e-15197111139fe1b757f76c2d43d39aa9ac500eaba98723985c
ToppCell5'-Parenchyma_lung-Immune_Lymphocytic-Lymphocytic_B-plasma_cell-Plasma_cells-Plasma_cells_L.1.7.0.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

IGKV1-17 IGKV1-12 IGKV1-9 IGKV1-6 MZB1 IGKV1-5 SDF2L1 CERCAM IGKV1D-43 IGHV6-1 IGKV1D-17 IGKV1D-13

3.47e-1418111112e47664a264a2c37390d1668ce04eef2e0172f4cb
ToppCellTracheal-10x5prime-Immune_Lymphocytic-B-B_plasma|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

IGKV1-37 IGKV1-17 IGKV1-13 IGKV1-12 IGKV1-6 MZB1 IGKV1D-43 IGHV6-1 IGKV1D-17 IGKV1D-13 IGKV1D-12 IGKV1D-8

7.48e-1419311112282b47dae6043eabb1e13d41d91c07b5ec21cd65
ToppCellTracheal-10x5prime-Immune_Lymphocytic-B-B_plasma-B_plasma_IgG|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

IGKV1-37 IGKV1-17 IGKV1-13 IGKV1-12 IGKV1-6 MZB1 IGKV1-5 IGKV1D-43 IGHV6-1 IGKV1D-17 IGKV1D-12 IGKV1D-8

7.96e-1419411112a4a70369541876e1192df8828b63e3d1746ae3d9
ToppCellhealthy_donor-Lymphocytic-Plasma_cell-IgA_Plasmablast|healthy_donor / Disease condition, Lineage, Cell class and subclass

IGKV1-17 IGKV1-9 IGKV1-6 MZB1 IGKV1-5 IGKV1D-43 IGKV1D-42 IGKV1D-37 IGKV1D-17 IGKV1D-13 IGKV1D-12

1.48e-1218611111e2c050ba02e1f84f0b7258dc92e7ff6ab349ff67
ToppCellhealthy_donor-Lymphocytic-Plasma_cell|healthy_donor / Disease condition, Lineage, Cell class and subclass

IGKV1-17 IGKV1-9 IGKV1-6 MZB1 IGKV1-5 SDF2L1 IGKV1D-42 IGKV1D-37 IGKV1D-17 IGKV1D-13 IGKV1D-12

1.66e-1218811111bd53b0371154cff680226897b61c9809a239d1b6
ToppCell10x_3'_v3-bone_marrow_(10x_3'_v3)-lymphocytic-B_lymphocytic-plasma_cell|bone_marrow_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

IGKV1-17 IGKV1-13 IGKV1-9 IGKV1-6 MZB1 IGKV1-5 SDF2L1 CERCAM IGHV6-1 IGKV1D-13 IGKV1D-8

1.76e-12189111115a42be62552d912d0abf68f00d75ac80bbd69f2c
ToppCellBronchial-10x5prime-Immune_Lymphocytic-B-B_plasma-B_plasma_IgG|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

IGKV1-17 IGKV1-13 IGKV1-12 IGKV1-6 MZB1 IGKV1-5 KISS1R IGHV6-1 IGKV1D-13 IGKV1D-12 IGKV1D-8

2.62e-1219611111fec21383435779bf4c632decd3d29c6ca7baebfb
ToppCell368C-Lymphocytic-Plasma_cell-|368C / Donor, Lineage, Cell class and subclass (all cells)

IGKV1-37 IGKV1-17 IGKV1-12 IGKV1-6 MZB1 IGKV1-5 KISS1R IGKV1D-13 IGKV1D-12 IGKV1D-8

1.04e-1116211110c21a54310b239d999bbc9d8fb5e8fda16e0bc336
ToppCell368C-Lymphocytic-Plasma_cell|368C / Donor, Lineage, Cell class and subclass (all cells)

IGKV1-37 IGKV1-17 IGKV1-12 IGKV1-6 MZB1 IGKV1-5 KISS1R IGKV1D-13 IGKV1D-12 IGKV1D-8

1.04e-1116211110f945688815229c8386cbcbf46deee7df316fa8d3
ToppCellmetastatic_Brain-B_lymphocytes-Plasma_cells|metastatic_Brain / Location, Cell class and cell subclass

IGKV1-17 IGKV1-12 IGKV1-9 IGKV1-6 MZB1 IGKV1-5 IGKV1D-43 IGHV6-1 IGKV1D-17 IGKV1D-8

1.69e-111701111053634da9e9c72f6400639954c286c6e38ea5a188
ToppCellCOPD-Lymphoid-B_Plasma|World / Disease state, Lineage and Cell class

IGKV1-17 IGKV1-13 IGKV1-12 IGKV1-9 MZB1 IGKV1-5 IGHV6-1 IGKV1D-17 IGKV1D-13 IGKV1D-8

2.25e-1117511110d73ee324479172501481b54967a0f3bd870fcf3a
ToppCellIPF-Lymphoid-B_Plasma|World / Disease state, Lineage and Cell class

IGKV1-37 IGKV1-13 IGKV1-12 MZB1 IGKV1-5 IGKV1D-43 IGHV6-1 IGKV1D-17 IGKV1D-12 IGKV1D-8

2.38e-1117611110cc0cab6487df6867b529596ec94f55d31aa6ca36
ToppCellControl-Lymphoid_P-Plasmablast|Control / Disease group, lineage and cell class

IGKV1-17 IGKV1-9 IGKV1-6 MZB1 IGKV1-5 IGKV1D-42 IGKV1D-37 IGKV1D-17 IGKV1D-13 IGKV1D-12

2.38e-11176111104b4416f342b732d2cc60133838728880326257d8
ToppCellControl-Lymphoid_P|Control / Disease group, lineage and cell class

IGKV1-17 IGKV1-9 IGKV1-6 MZB1 IGKV1-5 IGKV1D-42 IGKV1D-37 IGKV1D-17 IGKV1D-13 IGKV1D-12

2.38e-1117611110d895a6b295cd649273ff80ad7785a3e0ae4c728a
ToppCellPBMC-Control-Lymphocyte-B-Plasmablast-Plasmablast-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

IGKV1-17 IGKV1-9 IGKV1-6 MZB1 IGKV1-5 IGKV1D-37 IGKV1D-17 IGKV1D-13 IGKV1D-12 IGKV1D-8

2.51e-11177111104c434a7b7cc54cf4dac996bbc3f5124d9ef9a9cd
ToppCellPBMC-Control-Lymphocyte-B-Plasmablast-Plasmablast|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

IGKV1-17 IGKV1-9 IGKV1-6 MZB1 IGKV1-5 IGKV1D-37 IGKV1D-17 IGKV1D-13 IGKV1D-12 IGKV1D-8

2.51e-1117711110d746122bf8d208c3aa4d156e8c12d0a0e555c6e5
ToppCellPBMC-Control-Lymphocyte-B-Plasmablast|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

IGKV1-17 IGKV1-9 IGKV1-6 MZB1 IGKV1-5 IGKV1D-37 IGKV1D-17 IGKV1D-13 IGKV1D-12 IGKV1D-8

2.51e-1117711110fc40918825b7e1eb6861df59dfca944778a64b98
ToppCellPBMC-Control-Lymphocyte-B-Plasmablast|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

IGKV1-17 IGKV1-9 IGKV1-6 MZB1 IGKV1-5 IGKV1D-37 IGKV1D-17 IGKV1D-13 IGKV1D-12 IGKV1D-8

2.81e-1117911110837ed81f18257f444eaeadc4fac89deedd4e3061
ToppCellPBMC-Control-Lymphocyte-B-Plasmablast-Plasmablast-Plasmablast|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

IGKV1-17 IGKV1-9 IGKV1-6 MZB1 IGKV1-5 IGKV1D-37 IGKV1D-17 IGKV1D-13 IGKV1D-12 IGKV1D-8

2.81e-1117911110494febe77c6d4e6a2c6f0928bbf4c84b0301f188
ToppCellPBMC-Control-Lymphocyte-B-Plasmablast-Plasmablast|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

IGKV1-17 IGKV1-9 IGKV1-6 MZB1 IGKV1-5 IGKV1D-37 IGKV1D-17 IGKV1D-13 IGKV1D-12 IGKV1D-8

2.81e-1117911110b6ee4f41d8fb5f047b7bdd8489dda0a89fc6d43f
ToppCell10x5'-lymph-node_spleen-Lymphocytic_B_plasma-Plasma_cells|lymph-node_spleen / Manually curated celltypes from each tissue

IGKV1-17 IGKV1-13 IGKV1-9 MZB1 IGKV1-5 SDF2L1 CERCAM IGHV6-1 IGKV1D-13 IGKV1D-12

3.50e-1118311110a6866951866373a1029e04818f4a4a31278c409d
ToppCell3'-Parenchyma_lung-Immune_Lymphocytic-Lymphocytic_B-plasma_cell-Plasma_cells-Plasma_cells_L.1.7.0.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

IGKV1-17 IGKV1-12 IGKV1-9 IGKV1-6 MZB1 IGKV1-5 SDF2L1 IGHV6-1 IGKV1D-17 IGKV1D-8

3.50e-1118311110cf5c98f451a568308c52da5c926543dd4836c6b2
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Immune-Lymphocytic_B-Plasma_Cell-|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

IGKV1-17 IGKV1-9 IGKV1-6 MZB1 IGKV1-5 SDF2L1 IGHV6-1 IGKV1D-17 IGKV1D-13 IGKV1D-8

3.89e-11185111100fff2608f507e019ebb69c27e58fd5be3b049bef
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Immune-Lymphocytic_B-Plasma_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

IGKV1-17 IGKV1-9 IGKV1-6 MZB1 IGKV1-5 SDF2L1 IGHV6-1 IGKV1D-17 IGKV1D-13 IGKV1D-8

3.89e-111851111079edc1eeb7b5b9123961ac3ecf398ee68d9dddb9
ToppCell5'-Parenchyma_lung-Immune_Lymphocytic-Lymphocytic_B-plasma_cell-Plasma_cells|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

IGKV1-17 IGKV1-12 MZB1 IGKV1-5 SDF2L1 IGKV1D-43 IGHV6-1 IGKV1D-13 IGKV1D-12 IGKV1D-8

3.89e-111851111008bc817908076734d66f2805cb954141f2cc5a18
ToppCell5'-Parenchyma_lung-Immune_Lymphocytic-Lymphocytic_B-plasma_cell|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

IGKV1-17 IGKV1-12 MZB1 IGKV1-5 SDF2L1 IGKV1D-43 IGHV6-1 IGKV1D-13 IGKV1D-12 IGKV1D-8

3.89e-11185111101704a12153a9b107bf03ecccd1a036cf61334d7a
ToppCellIPF-Lymphoid-B_Plasma|Lymphoid / Disease state, Lineage and Cell class

IGKV1-17 IGKV1-13 IGKV1-12 MZB1 IGKV1-5 SDF2L1 IGHV6-1 IGKV1D-17 IGKV1D-12 IGKV1D-8

4.11e-1118611110f9c21daf905d0bb0e0e769ca4bb069ea4b1ba25b
ToppCell5'-Adult-LargeIntestine-Hematopoietic|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

IGKV1-17 IGKV1-9 IGKV1-6 MZB1 IGKV1-5 IGKV1D-43 IGHV6-1 IGKV1D-17 IGKV1D-13 IGKV1D-8

5.33e-1119111110d1d30279ed4612b4f62c225d9eabf0b8a7a09d11
ToppCellTracheal-10x5prime-Immune_Lymphocytic-B-B_plasma-B_plasma_IgA|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

IGKV1-37 IGKV1-17 IGKV1-12 IGKV1-6 MZB1 KISS1R IGHV6-1 IGKV1D-17 IGKV1D-13 IGKV1D-12

6.54e-1119511110df009b18898c10686f75cf72b4ec0eff18f5bb50
ToppCellBronchial-10x5prime-Immune_Lymphocytic-B-B_plasma|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

IGKV1-13 IGKV1-12 IGKV1-6 MZB1 IGKV1-5 KISS1R IGHV6-1 IGKV1D-13 IGKV1D-12 IGKV1D-8

6.88e-1119611110c38e7f533c619afe008de0e99042f7180c2da918
ToppCell10x5'-blood-Lymphocytic_B_plasma-Plasma_cells|blood / Manually curated celltypes from each tissue

IGKV1-13 IGKV1-9 IGKV1-6 MZB1 IGKV1-5 SDF2L1 IGKV1D-43 IGHV6-1 IGKV1D-13

1.26e-10147111958089378fac1743ce99dc4f1bd7b5253a927f050
ToppCell10x5'-blood-Lymphocytic_B_plasma|blood / Manually curated celltypes from each tissue

IGKV1-13 IGKV1-9 IGKV1-6 MZB1 IGKV1-5 SDF2L1 IGKV1D-43 IGHV6-1 IGKV1D-13

1.51e-1015011196bab0a8bf78ed7de9e1b67ede7496488f80f4863
ToppCelltumor_Lymph_Node_/_Brain-B_lymphocytes-MALT_B_cells|tumor_Lymph_Node_/_Brain / Location, Cell class and cell subclass

IGKV1-17 IGKV1-12 IGKV1-9 IGKV1-6 MZB1 IGKV1-5 SDF2L1 IGKV1D-37 IGHV6-1

2.54e-101591119204e5a675f4684c9570c24c8d34bbf632fd8164a
ToppCell3'_v3-blood-Lymphocytic_B_plasma-Plasma_cells|blood / Manually curated celltypes from each tissue

IGKV1-17 IGKV1-12 MZB1 IGKV1-5 SDF2L1 IGHV6-1 IGKV1D-17 IGKV1D-13 IGKV1D-8

3.53e-1016511191c0c24fe252b761cf879b83562e23c02f0b6489f
ToppCell367C-Lymphocytic-Plasma_cell-|367C / Donor, Lineage, Cell class and subclass (all cells)

IGKV1-37 IGKV1-12 IGKV1-6 MZB1 IGKV1-5 KISS1R IGKV1D-43 IGHV6-1 IGKV1D-12

3.93e-101671119f2185eb72f0137136f6d71af2a70168fded6c940
ToppCell367C-Lymphocytic-Plasma_cell|367C / Donor, Lineage, Cell class and subclass (all cells)

IGKV1-37 IGKV1-12 IGKV1-6 MZB1 IGKV1-5 KISS1R IGKV1D-43 IGHV6-1 IGKV1D-12

3.93e-1016711195e768cf24699893e05d1bcb1c92dba2336943a64
ToppCellmetastatic_Brain-B_lymphocytes-MALT_B_cells|metastatic_Brain / Location, Cell class and cell subclass

IGKV1-17 IGKV1-12 IGKV1-9 IGKV1-6 MZB1 IGKV1-5 IGHV6-1 IGKV1D-13 IGKV1D-12

6.27e-10176111950e207403d48ce1b55a78897adb5519a2430a626
ToppCell3'-Broncho-tracheal-Immune_Lymphocytic-Lymphocytic_B-plasma_cell-Plasma_cells-Plasma_cells_L.1.7.0.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

IGKV1-17 IGKV1-12 IGKV1-9 IGKV1-6 MZB1 IGKV1-5 SDF2L1 IGKV1D-43 IGKV1D-17

7.64e-101801119cea079bc02e08c46600eed05ab9924ec90e1e3d3
ToppCell3'-Parenchyma_lung-Immune_Lymphocytic-Lymphocytic_B-plasma_cell-Plasma_cells-Plasma_cells_L.1.7.0.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

IGKV1-37 IGKV1-12 IGKV1-9 IGKV1-6 MZB1 IGKV1-5 SDF2L1 CERCAM IGKV1D-13

8.43e-1018211191bf2e4fd6222b41a7d08df6dcc500c9401db8c18
ToppCell3'_v3-blood-Lymphocytic_B_plasma|blood / Manually curated celltypes from each tissue

IGKV1-17 IGKV1-12 IGKV1-6 MZB1 IGKV1-5 SDF2L1 IGHV6-1 IGKV1D-13 IGKV1D-8

8.84e-1018311192477183a290b2c45b6fa091ed76969a3826fe3d9
ToppCell10x5'-Liver-Lymphocytic_B_plasma-Plasma_cells|Liver / Manually curated celltypes from each tissue

IGKV1-17 IGKV1-13 IGKV1-12 IGKV1-9 MZB1 SDF2L1 IGHV6-1 IGKV1D-13 IGKV1D-12

9.28e-1018411196f70d8f8ab8362d51f8a58735d42223e06566397
ToppCell3'-Parenchyma_lung-Immune_Lymphocytic-Lymphocytic_B-plasma_cell-Plasma_cells|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

IGKV1-17 IGKV1-12 IGKV1-9 IGKV1-6 MZB1 IGKV1-5 SDF2L1 IGHV6-1 IGKV1D-8

9.74e-1018511196ec009e48e50471c28e914c402f500e56a88f8f2
ToppCell3'-Parenchyma_lung-Immune_Lymphocytic-Lymphocytic_B-plasma_cell|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

IGKV1-17 IGKV1-12 IGKV1-9 IGKV1-6 MZB1 IGKV1-5 SDF2L1 IGHV6-1 IGKV1D-8

9.74e-101851119f49ad6401b2abd089e30eba245b11b5031ea2318
ToppCellCOVID-19-lung-Plasmablasts|lung / Disease (COVID-19 only), tissue and cell type

IGKV1-12 IGKV1-9 IGKV1-6 MZB1 IGKV1-5 SDF2L1 IGHV6-1 IGKV1D-12 IGKV1D-8

1.02e-09186111981caf67da9fed09c77b7ddcab9b0b8e4fab2de97
ToppCell10x_3'_v3-bone_marrow_(10x_3'_v3)-lymphocytic-B_lymphocytic|bone_marrow_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

IGKV1-17 IGKV1-13 IGKV1-9 IGKV1-6 MZB1 IGKV1-5 SDF2L1 IGHV6-1 IGKV1D-8

1.23e-091901119a21d0c574abf21e7cb865a21a48f29c92d055fbe
ToppCellTracheal-10x5prime-Immune_Lymphocytic-B|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

IGKV1-37 IGKV1-17 IGKV1-12 IGKV1-6 MZB1 IGKV1D-17 IGKV1D-13 IGKV1D-12 IGKV1D-8

1.69e-0919711192662138671262b30508c5759038bcdcfe6551696
ToppCellmetastatic_Lymph_Node-B_lymphocytes-Plasma_cells|metastatic_Lymph_Node / Location, Cell class and cell subclass

IGKV1-37 IGKV1-12 IGKV1-9 MZB1 IGKV1-5 SDF2L1 IGKV1D-37 IGHV6-1

2.71e-0914211185ba3a33c2ee20be8baaed97536ca6e9d1de6752f
ToppCellnormal_Lung-B_lymphocytes-MALT_B_cells|normal_Lung / Location, Cell class and cell subclass

IGKV1-12 IGKV1-9 IGKV1-6 MZB1 IGKV1-5 IGKV1D-43 IGKV1D-13 IGKV1D-8

6.61e-091591118fbd0131b66f4267f7b0d6c3ad874ad097b859074
ToppCell390C-Lymphocytic-Plasma_cell|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

IGKV1-12 IGKV1-9 IGKV1-6 MZB1 MTMR11 IGKV1D-43 IGKV1D-8 CTSZ

9.27e-0916611184ba3711a02d3695b27f7cefd7c60e3be009f5bef
ToppCell390C-Lymphocytic-Plasma_cell-|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

IGKV1-12 IGKV1-9 IGKV1-6 MZB1 MTMR11 IGKV1D-43 IGKV1D-8 CTSZ

9.27e-09166111835f6ae2664935dda0d883b32a050ced843204f2d
ToppCell10x5'-GI_large-bowel|World / Manually curated celltypes from each tissue

IGKV1-13 IGKV1-12 IGKV1-9 IGKV1-6 MZB1 IGKV1-5 SDF2L1 IGKV1D-8

1.02e-0816811181290c909655bc37f6b8bf216d18127a21b99e9c0
ToppCellBAL-Mild-Lymphocyte-B|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

IGKV1-12 IGKV1-9 IGKV1-6 MZB1 IGKV1-5 PTPRK IGHV6-1 IGKV1D-12

1.07e-081691118307571e57c3bfdf15f0fe1a8b36585e8e4f8a207
ToppCellControl-Lymphoid-B_Plasma|Control / Disease state, Lineage and Cell class

IGKV1-13 IGKV1-12 MZB1 IGKV1-5 IGKV1D-43 IGHV6-1 IGKV1D-13 IGKV1D-8

1.22e-08172111861e33836b8cb0f347f3e699eb587a37073b6fa4c
ToppCell10x5'-bone_marrow-Lymphocytic_B_plasma-Plasma_cells|bone_marrow / Manually curated celltypes from each tissue

IGKV1-13 IGKV1-6 MZB1 IGKV1-5 SDF2L1 CERCAM IGHV6-1 IGKV1D-13

1.28e-081731118300904fd35536a69be81d76fe33fe16544523ceb
ToppCellPlasma_cells|World / lung cells shred on cell class, cell subclass, sample id

IGKV1-12 IGKV1-9 IGKV1-6 MZB1 IGKV1-5 SDF2L1 IGHV6-1 IGKV1D-8

1.28e-08173111852a387e2a4694af61a9223a4c2ecf4e6f762c064
ToppCell10x5'-bone_marrow-Lymphocytic_B_plasma|bone_marrow / Manually curated celltypes from each tissue

IGKV1-13 IGKV1-6 MZB1 IGKV1-5 SDF2L1 CERCAM IGHV6-1 IGKV1D-13

1.34e-081741118b1931028cf80af5eff6da15d7f0196205f17926f
ToppCell(2)_Plasma_cells|World / Lung cell shreds - cell class (v4) and cell subclass (v4)

IGKV1-37 IGKV1-17 IGKV1-12 IGKV1-6 MZB1 IGKV1-5 IGHV6-1 IGKV1D-8

1.53e-081771118ed3c936bb69f9bc7291b4f6cde1d204078117c48
ToppCellCOPD-Lymphoid-B_Plasma|COPD / Disease state, Lineage and Cell class

IGKV1-17 IGKV1-13 IGKV1-12 MZB1 IGKV1-5 IGHV6-1 IGKV1D-17 IGKV1D-8

1.53e-0817711181b872d3b1e0fca138362098590a634d748dfca60
ToppCell5'-Parenchyma_lung-Immune_Lymphocytic-Lymphocytic_B-plasma_cell-Plasma_cells-Plasma_cells_L.1.7.1.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

IGKV1-37 IGKV1-12 MZB1 IGKV1-5 IGHV6-1 IGKV1D-13 IGKV1D-12 IGKV1D-8

1.74e-081801118e3877f6ef5f54ff689058b4c996ab1851822f871
ToppCellnormal_Lymph_Node-B_lymphocytes-Plasma_cells|normal_Lymph_Node / Location, Cell class and cell subclass

IGKV1-17 IGKV1-12 IGKV1-6 MZB1 IGKV1-5 SDF2L1 CERCAM IGKV1D-12

1.82e-081811118949ac3b60e7fb5968da4c4e872965fb4e10f4a35
ToppCell368C-Lymphocytic-Plasma_cell|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

IGKV1-17 IGKV1-12 IGKV1-6 MZB1 IGKV1-5 SDF2L1 CERCAM IGKV1D-8

1.98e-0818311187733cf919eda146efe41c93990658ce92db73aa8
ToppCellcellseq-Immune-Lymphocytic_B-Lymphocytic_B-Plasma|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

IGKV1-12 MZB1 IGKV1-5 SDF2L1 IGHV6-1 IGKV1D-13 IGKV1D-12 IGKV1D-8

1.98e-0818311185ab4aa0304b832f98fff89b6c24ad5b7dd014c11
ToppCell368C-Lymphocytic-Plasma_cell-|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

IGKV1-17 IGKV1-12 IGKV1-6 MZB1 IGKV1-5 SDF2L1 CERCAM IGKV1D-8

1.98e-081831118d91441cbf94f5c3b7c36f2ca3a46895870bd730f
ToppCellMild_COVID-19-B_cell-B_cell|Mild_COVID-19 / Disease group,lineage and cell class （2021.01.30）

IGKV1-17 IGKV1-9 IGKV1-6 IGKV1-5 FADS3 PTPRK IGHV6-1 IGKV1D-8

2.25e-081861118855a5a00ba2aa1b5c63b8db56d026ddecc546050
ToppCell5'-Parenchyma_lung-Immune_Lymphocytic-Lymphocytic_B-plasma_cell-Plasma_cells-Plasma_cells_L.1.7.1.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

IGKV1-17 IGKV1-12 IGKV1-9 MZB1 SDF2L1 IGHV6-1 IGKV1D-13 IGKV1D-8

2.45e-0818811186844cebca177fdf38b21a40d606230a033717a3a
ToppCellCOVID-19-lung-Plasmablasts|COVID-19 / Disease (COVID-19 only), tissue and cell type

IGKV1-12 IGKV1-6 MZB1 IGKV1-5 SDF2L1 IGHV6-1 IGKV1D-12 IGKV1D-8

2.55e-081891118fdf6c945b352614885e646a5ef4bc576dee73895
ToppCellTCGA-Stomach-Solid_Tissue_Normal-Stomach_normal_tissue-Stomach_normal_tissue-2|TCGA-Stomach / Sample_Type by Project: Shred V9

IGKV1-37 MGAM IGKV1D-42 IGKV1D-37 IGKV1D-17 IGKV1D-12 IGKV1D-8

2.73e-0812411179d62f997a1a389386e8d83652bdf109c2a1c96d8
ToppCellTracheal-10x3prime_v2-Immune_Lymphocytic-B-B_plasma-B_plasma_IgA|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

IGKV1-12 IGKV1-9 MZB1 SDF2L1 IGKV1D-43 IGHV6-1 IGKV1D-17 IGKV1D-13

2.77e-081911118da4062a0f6d0af6d330acf11da216c64b0fa7c73
ToppCell5'-Adult-LargeIntestine-Hematopoietic-Plasma_cells-IgG_plasma_cell|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

IGKV1-17 IGKV1-9 IGKV1-6 MZB1 IGKV1-5 SDF2L1 IGKV1D-17 IGKV1D-13

3.12e-081941118f083777353e76a2d9c39f8b6cb1a689b68b81c56
ToppCellBronchial-10x5prime-Immune_Lymphocytic-B-B_plasma-B_plasma_IgA|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

IGKV1-12 IGKV1-6 MZB1 IGKV1-5 IGKV1D-37 IGHV6-1 IGKV1D-13 IGKV1D-8

3.25e-08195111813f4ee21568fd747608412d33559d10561dbb3c8
ToppCellBiopsy_Other_PF-Immune-Plasma_cells|Biopsy_Other_PF / Sample group, Lineage and Cell type

IGKV1-37 IGKV1-12 IGKV1-6 MZB1 IGKV1-5 IGHV6-1 IGKV1D-13 IGKV1D-8

3.25e-081951118d0305c6a68c9e361507b04db94f86873085d49b3
ToppCellCOVID_vent-Lymphocytic-Plasma_cell-IgM_Plasmablast|COVID_vent / Disease condition, Lineage, Cell class and subclass

IGKV1-17 IGKV1-12 IGKV1-9 MZB1 IGKV1-5 SDF2L1 IGHV6-1 IGKV1D-17

3.38e-081961118026a06d8d2089806823e6f6453d3ede84ae93bc6
ToppCellParenchymal-10x3prime_v2-Immune_Lymphocytic-B-B_plasma|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

IGKV1-17 IGKV1-12 MZB1 IGKV1-5 SDF2L1 IGHV6-1 IGKV1D-13 IGKV1D-8

3.38e-081961118b3d5540fe8ab9a9cbb9ab5350f5cb0e1aae93584
ToppCellCOVID_non-vent-Lymphocytic-Plasma_cell-IgG_Plasmablast|COVID_non-vent / Disease condition, Lineage, Cell class and subclass

IGKV1-17 IGKV1-12 IGKV1-9 MZB1 IGKV1-5 SDF2L1 IGKV1D-13 IGKV1D-8

3.52e-081971118b754fad4f3caae6de95df901fd96ea8697fe41b1
ToppCell390C-Lymphocytic-Plasma_cell-|390C / Donor, Lineage, Cell class and subclass (all cells)

IGKV1-12 IGKV1-9 IGKV1-6 MZB1 IGKV1-5 IGKV1D-43 IGKV1D-8

1.32e-0715611174f92ca30755430db44402afc603d1ecd8bfc3617
ToppCell390C-Lymphocytic-Plasma_cell|390C / Donor, Lineage, Cell class and subclass (all cells)

IGKV1-12 IGKV1-9 IGKV1-6 MZB1 IGKV1-5 IGKV1D-43 IGKV1D-8

1.32e-0715611170de2fc695bd5f8d4633c514f71ea941c88137bac
ToppCell5'-Parenchyma_lung-Immune_Lymphocytic-Lymphocytic_B-B_cell-B_cells-B_cells_L.1.5.0.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

IGKV1-9 IGKV1-6 IGKV1-5 IGKV1D-43 IGKV1D-13 IGKV1D-12 IGKV1D-8

1.71e-071621117b46158e260bd2f35702cec73e3b035e8e9ec4469
ToppCelltumor_Lung-B_lymphocytes-Plasma_cells|tumor_Lung / Location, Cell class and cell subclass

IGKV1-12 IGKV1-9 IGKV1-6 MZB1 SHBG IGKV1-5 SDF2L1

2.28e-071691117b36b7632ce55fc7b6b8b66020563d360b3de6fd7
ToppCellBAL-Mild-Lymphocyte-B-B_cell-B_cell-B_activate-7|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

IGKV1-12 IGKV1-9 IGKV1-6 IGKV1-5 PTPRK IGHV6-1 IGKV1D-12

2.37e-071701117ee2ee67d90ae4596de8ccd620e37c82cf51651d4
ToppCellBAL-Mild-Lymphocyte-B-B_cell-B_cell|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

IGKV1-12 IGKV1-9 IGKV1-6 IGKV1-5 PTPRK IGHV6-1 IGKV1D-12

2.37e-071701117d7ca0c6ce5d2b7de99346f87e07aa7fe728fa08a
ToppCellBAL-Mild-Lymphocyte-B-B_cell|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

IGKV1-12 IGKV1-9 IGKV1-6 IGKV1-5 PTPRK IGHV6-1 IGKV1D-12

2.37e-07170111752787f6d529c285d9f0c04cc022710ead5b89b3f
ToppCell5'-Parenchyma_lung-Immune_Lymphocytic-Lymphocytic_B-plasma_cell-Plasma_cells-Plasma_cells_L.1.7.0.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

IGKV1-12 IGKV1-6 MZB1 SDF2L1 IGKV1D-43 IGHV6-1 IGKV1D-8

2.67e-0717311177e6bfe85f60834f317941b70d6e0dc3bd527d293
ToppCellkidney_cells-Hypertensive_with+without-CKD-Immune-Lymphocytic_B-Plasma_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

IGKV1-17 IGKV1-9 IGKV1-6 MZB1 IGKV1-5 SDF2L1 IGHV6-1

3.12e-071771117c2b0fb5921eea24d248d6e6ccb57c29b0832602c
ToppCellVE-plasma|VE / Condition, Cell_class and T cell subcluster

IGKV1-13 IGKV1-12 IGKV1-6 MZB1 IGHV6-1 IGKV1D-13 IGKV1D-12

3.12e-0717711170c1cc0834de55717cb4f69d020339060ce2c9a03
ToppCellkidney_cells-Hypertensive_with+without-CKD-Immune-Lymphocytic_B-Plasma_Cell-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

IGKV1-17 IGKV1-9 IGKV1-6 MZB1 IGKV1-5 SDF2L1 IGHV6-1

3.12e-071771117111fb0707ff37ca631d85bb5a09e067ffe568eb8
ToppCellVE-plasma-|VE / Condition, Cell_class and T cell subcluster

IGKV1-13 IGKV1-12 IGKV1-6 MZB1 IGHV6-1 IGKV1D-13 IGKV1D-12

3.12e-0717711173a3c94cf30012e2aa266bc4d7fe772e45fa90f6d
ToppCell5'-Parenchyma_lung-Immune_Lymphocytic-Lymphocytic_B|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

IGKV1-12 IGKV1-9 MZB1 IGKV1-5 IGHV6-1 IGKV1D-13 IGKV1D-8

3.24e-071781117107dae8b00c4257697a63700e72bb434cdb8406f
ToppCell10x5'-lymph-node_spleen-Lymphocytic_B_plasma|lymph-node_spleen / Manually curated celltypes from each tissue

IGKV1-17 IGKV1-9 MZB1 IGKV1-5 SDF2L1 IGHV6-1 IGKV1D-12

3.90e-071831117beadc69f511cf183e493cb445135f0748ab8b20e
ToppCell367C-Lymphocytic-Plasma_cell-|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

IGKV1-12 IGKV1-6 MZB1 IGKV1-5 SDF2L1 CERCAM IGHV6-1

4.05e-07184111714a5288d861260f63fbe0cbea3569cf643e7597e
ToppCell367C-Lymphocytic-Plasma_cell|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

IGKV1-12 IGKV1-6 MZB1 IGKV1-5 SDF2L1 CERCAM IGHV6-1

4.05e-071841117fc708a5c8a7b19fab973c72dc4383a7d30f8b59a
ToppCell3'-Broncho-tracheal-Immune_Lymphocytic-Lymphocytic_B-plasma_cell-Plasma_cells|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

IGKV1-17 IGKV1-12 IGKV1-9 IGKV1-6 MZB1 IGKV1-5 SDF2L1

4.05e-07184111715f2c10101ccc8ed059520fc082ee42593dff269
ToppCell3'-Broncho-tracheal-Immune_Lymphocytic-Lymphocytic_B-plasma_cell|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

IGKV1-17 IGKV1-12 IGKV1-9 IGKV1-6 MZB1 IGKV1-5 SDF2L1

4.05e-071841117a90a58d9e319afa1cd572e4c2f516fadc42f56e5
Diseasemarginal zone B- and B1-cell-specific protein measurement

MZB1 DNAH12

6.39e-054972EFO_0802730
Diseasepersistent Staphylococcus aureus carrier status

FGF3 FGF4

1.59e-046972EFO_0007757
Diseasedolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 measurement

SIGLEC14 SIGLEC5

4.73e-0410972EFO_0801544
Diseasesialic acid-binding Ig-like lectin 14 measurement

SIGLEC14 SIGLEC5

6.91e-0412972EFO_0008284
DiseaseProstatic Neoplasms

PRSS8 SHBG LAMB2 ANTXR2 PTPRK SDF2L1 CDH12 IL27

9.78e-04616978C0033578
DiseaseMalignant neoplasm of prostate

PRSS8 SHBG LAMB2 ANTXR2 PTPRK SDF2L1 CDH12 IL27

9.78e-04616978C0376358
Diseasehemifacial microsomia

NID2 FGF3

1.76e-0319972MONDO_0015398
Diseaseshort-term memory

TTYH1 DNAH12 PTPRK

2.62e-0383973EFO_0004335
Diseaseankylosing spondylitis, psoriasis, ulcerative colitis, Crohn's disease, sclerosing cholangitis

THADA ANTXR2 PTPRK LTBR IL27

2.94e-03295975EFO_0000384, EFO_0000676, EFO_0000729, EFO_0003898, EFO_0004268

Protein segments in the cluster

PeptideGeneStartEntry
LQGLAFWQGVPLSPL

TTYH1

186

Q9H313
LGLLLGKIWPLFPVF

DCUN1D4

221

Q92564
LLGTVGLFLPPWLAG

CHRNA4

611

P43681
PGWRPLLLLVLLAGA

CTSZ

6

Q9UBR2
ILKPGGIWINLGPLL

CARNMT1

331

Q8N4J0
AAPGPVWILAPLLLL

ADGRB1

6

O14514
LWALGLLGAGSPLPS

ADAM15

6

Q13444
PALWALLLALLGTAP

C20orf204

6

A0A1B0GTL2
FPLLPLVLGLAFLHW

APCDD1L

486

Q8NCL9
FPGLWLLVLSGPGGL

ANTXR2

16

P58335
FIRLLPQTWLQGGAP

CPXM1

251

Q96SM3
LLLLLLLWPVPGAGV

ADAM33

16

Q9BZ11
SLVPGPAFLALNWLG

ADRB3

321

P13945
LLLLLLFLGPWPAAS

LRPAP1

16

P30533
ALPLQALLLEAPWTG

NFILZ

106

A0A5F9ZHS7
LGLQWNSLPALPGIR

RGPD5

441

Q99666
LGLQWNSLPALPGIR

RGPD8

441

O14715
RPGLLLPGLWLLLLA

KIAA1549

41

Q9HCM3
AAARNLWGNLPPLLL

CT47A1

156

Q5JQC4
LWGNLPPLLLPQRLG

CT47A1

161

Q5JQC4
ILPSLWLLLLGGPAC

FCN3

6

O75636
LVPAFLLIGWGRSLP

MFSD10

346

Q14728
GSGLPWLLLLLPPLS

ABCC10

1061

Q5T3U5
GLSLFLNLPGPIWLQ

CRELD1

16

Q96HD1
PGASQPLLAWLLLPL

PTPRE

41

P23469
PAQLLGLLLLWFPGS

IGKV1D-12

6

P01611
VGLPVPWLLFSLING

SLC24A1

1016

O60721
ILGNPAGWPVLLALT

SLC2A7

191

Q6PXP3
GLLLPGYLGPQIRLW

MTMR11

621

A4FU01
GLLTGLALPTLPGLW

GPBAR1

61

Q8TDU6
LLGLAWLALILPLGP

KCNK16

241

Q96T55
LGGLPSWLLQDPRLL

GLB1L3

171

Q8NCI6
PAQRLGLLLLWFPGA

IGKV1D-43

6

A0A0B4J1Z2
QQFLWGPGLLITPVL

MGAM

756

O43451
PAQLLGLLLLWVPGA

IGKV1D-37

6

P0DSN7
LLLLSLLEPGWPAAG

FGF3

6

P11487
KPGGWLPLLLLSLLV

IL17RB

286

Q9NRM6
PAQLLGLLLLWLPGA

IGKV1D-8

6

A0A087WSZ0
PAQLLGLLLLWLPGA

IGKV1D-13

6

A0A0B4J2D9
PQPWALGLLLFLLPG

FCGRT

6

P55899
LLPAVLLALLAPWAG

FGF4

11

P08620
ALLRGLFAWLIPPSL

DNAH12

1706

Q6ZR08
WGPIQLFLVLQALGP

KISS1R

276

Q969F8
PAQLLGLLLLWFPGA

IGKV1D-17

6

A0A075B6S4
GQPLPWELRLGLLLS

LAMB2

11

P55268
APLAWDLGLLLLFVG

NRM

61

Q8IXM6
FLGLLFLQPLWVAPV

LAG3

6

P18627
GLLLWSGLALGALPF

OSTM1

21

Q86WC4
AAPLWGPPGLLLAIA

FOXRED2

6

Q8IWF2
SWLGGFLAILPPIIL

OR6C4

146

Q8NGE1
LIFLPVLGLPWGVLS

IGHV6-1

6

A0A0B4J1U7
GGALLALLPTFSWPQ

MFSD3

151

Q96ES6
PLALLPLDSFEGWLL

OSBP2

176

Q969R2
WALAGGLLLSLGPAL

LY6H

121

O94772
QLFPGLRPWLAVLAG

MOGAT3

136

Q86VF5
LGLPLFLFPGAWAQG

GPRC5C

11

Q9NQ84
LPLTPIGGLFGWLFA

NID2

581

Q14112
GQRLPAAWVLLLLPF

PPT2

6

Q9UMR5
FWGHPAGPLLLLLLL

ACP4

6

Q9BZG2
LGLQWNSLPALPGIR

RGPD3

441

A6NKT7
LPGLLLLLVPVLWAG

HTRA4

16

P83105
QGFKLWLGPTFPLLI

CYP4F11

86

Q9HBI6
LLPLLLVQAGVWGFP

IL27

16

Q8NEV9
APPELLLLALGALGW

CERS1

56

P27544
LLLLALLLPVGAWPG

C1QTNF8

6

P60827
ILGGLLGFIPVAWNL

CLDN2

126

P57739
PAQLLGLLLLWLPGA

IGKV1-5

6

P01602
PAQLLGLLLLWLPGA

IGKV1-6

6

A0A0C4DH72
GLLLPPAAPFWLLNV

LCAT

16

P04180
PAQLLGLLLLWLPGA

IGKV1-9

6

A0A0C4DH69
PAQLLGLLLLWFPGS

IGKV1-12

6

A0A0C4DH73
PAQLLGLLLLWLPGA

IGKV1-13

6

P0DP09
PAQLLGLLLLWFPGA

IGKV1-17

6

P01599
PAQLLGLLLLWVPGA

IGKV1-37

6

A0A075B6S9
LWVLFDGGLLTPLQP

CDH12

11

P55289
QLLLLLGPWLEAAGV

CERCAM

11

Q5T4B2
LLIYLLGPGWVPSAL

FADS3

151

Q9Y5Q0
LLLLLVVPAAWGCGP

IHH

16

Q14623
HGALLFLWLFSPPLG

LRRC4B

21

Q9NT99
AFVALLLLSPWPLLG

PTPRK

11

Q15262
LLLSPWPLLGSAQGQ

PTPRK

16

Q15262
PAWALVLLGPALVFA

INSL3

6

P51460
LGLQWNSLPALPGIR

RGPD4

441

Q7Z3J3
LPWALLLLATALGPG

SUSD2

6

Q9UGT4
PWILPFLGPLAAIIL

ERVW-1

446

Q9UQF0
LPGLWAAALLLLGLP

SUSD5

16

O60279
APGLPILLGWLLGES

THADA

1796

Q6YHU6
LNVLAGALFGPWLGL

TMEM41A

91

Q96HV5
MAPAFLLLLLLWPQG

TREML2

1

Q5T2D2
ASLDLSPLLGFWQLP

PLAGL1

376

Q9UM63
PAAPWLLLGVLLLPG

NFAM1

21

Q8NET5
PARWLGTGLLGLFLL

SCN4B

11

Q8IWT1
LALPPLGLAPLLNLW

SHBG

326

P04278
LGLAPLLNLWAKPQG

SHBG

331

P04278
LLPLLWGGSLQEKPV

SIGLEC5

6

O15389
WLLQGPLGTLLPQGL

TAP2

21

Q03519
PLGTLLPQGLPGLWL

TAP2

26

Q03519
FLILLSCPWIQGLPL

SEZ6L2

16

Q6UXD5
FLPLGLALGLLSPWL

PRSS8

326

Q16651
ALALCLLLAPPGLAW

NPB

11

Q8NG41
GDLLPPAWLRALGAL

CNNM1

216

Q9NRU3
LAPAGGTLLLLGWLA

TMEM256

96

Q8N2U0
PLALLVLLLLGPGGW

PIGT

6

Q969N2
WPVLLGLLLALLVPG

SDF2L1

11

Q9HCN8
LGLLEELAWNLPPGP

PLAC9

71

Q5JTB6
PAGLAILRPNLSLLW

WDR97

171

A6NE52
GPLLLNLWAVPIGGP

SCART1

11

Q4G0T1
LPRWQLALAVGAPLL

TOMM70

36

O94826
GLAWGPLVLGLFGLL

LTBR

11

P36941
ALAPWPIVGLGKFLL

TMEM245

421

Q9H330
GWLALAVLLPGFLVQ

XKR5

36

Q6UX68
NEPGAFWGLILGLLI

SLC5A1

481

P13866
LLPLLWGGSLQEKPV

SIGLEC14

6

Q08ET2
PVLFLGKPLFLLWLH

ATP6V0A2

661

Q9Y487
PAQLLGLLLLWLPGV

IGKV1D-42

6

A0A075B6H8
PLLLLLLGAWAIPGG

MZB1

6

Q8WU39