Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctioncytoskeletal protein binding

PDE4B SPTB SPTBN1 APC2 MAPK8IP3 HAUS4 DST NPC1L1 MICAL3 UTRN PLS1 PLS3 ROCK2 KIF13B DIP2B VPS18 SYNE1 ARFGEF2 ARFGEF1 SPAG9 LCP1 OPA1 LRPPRC XIRP2 FARP1 CEP135 MACF1 DAAM2 ROCK1

4.65e-06109921029GO:0008092
GeneOntologyMolecularFunctionminus-end-directed microtubule motor activity

DNAH5 DNAH3 DNAH2 DNAH1

3.24e-05182104GO:0008569
GeneOntologyMolecularFunctionpolypeptide N-acetylgalactosaminyltransferase activity

GALNT1 GALNT2 GALNT3 GALNT12

5.05e-05202104GO:0004653
GeneOntologyMolecularFunctionmanganese ion binding

GALNT1 GALNT2 GALNT3 XPNPEP1 PPEF1 PCK1

1.02e-04712106GO:0030145
GeneOntologyMolecularFunctionRho-dependent protein serine/threonine kinase activity

ROCK2 ROCK1

1.10e-0422102GO:0072518
GeneOntologyMolecularFunctionGTPase binding

SPTBN1 RABGAP1L NPC1L1 FGD1 DOCK2 ROCK2 TBC1D30 LCP1 FARP1 DAAM2 ROCK1 RIMS1 RIMS2

1.20e-0436021013GO:0051020
GeneOntologyMolecularFunctiondynein light intermediate chain binding

DNAH5 DNAH3 DNAH2 DNAH1

2.00e-04282104GO:0051959
GeneOntologyMolecularFunctionMAP-kinase scaffold activity

MAPK8IP3 SH3RF1 SPAG9

3.03e-04132103GO:0005078
GeneOntologyMolecularFunctionacetylgalactosaminyltransferase activity

GALNT1 GALNT2 GALNT3 GALNT12

4.82e-04352104GO:0008376
GeneOntologyMolecularFunctionactin binding

SPTB SPTBN1 DST MICAL3 UTRN PLS1 PLS3 VPS18 SYNE1 LCP1 LRPPRC XIRP2 MACF1 DAAM2

5.74e-0447921014GO:0003779
GeneOntologyMolecularFunctiondynein intermediate chain binding

DNAH5 DNAH3 DNAH2 DNAH1

5.98e-04372104GO:0045505
GeneOntologyMolecularFunctionsmall GTPase binding

RABGAP1L NPC1L1 FGD1 DOCK2 ROCK2 TBC1D30 FARP1 DAAM2 ROCK1 RIMS1 RIMS2

6.18e-0432121011GO:0031267
GeneOntologyMolecularFunctionactin filament binding

SPTB SPTBN1 PLS1 PLS3 SYNE1 LCP1 LRPPRC XIRP2 MACF1

6.93e-042272109GO:0051015
GeneOntologyMolecularFunctionmicrotubule motor activity

DNAH5 KIF13B DNAH3 DNAH2 DNAH1

8.53e-04702105GO:0003777
GeneOntologyMolecularFunctionhigh-affinity L-glutamate transmembrane transporter activity

SLC1A6 SLC1A7

1.08e-0352102GO:0005314
GeneOntologyMolecularFunctionglutamate:sodium symporter activity

SLC1A6 SLC1A7

1.08e-0352102GO:0015501
GeneOntologyBiologicalProcessmicrotubule-based process

IFT172 APC2 STARD7 BLOC1S1 CUL7 MAPK8IP3 HAUS4 DST CFAP206 DNAH5 ATG5 ROCK2 KIF13B DNAH3 DNAH2 OPA1 DNAH1 WDR19 PPP2R1A LRPPRC CCDC42 TTC29 CEP135 MACF1 ROCK1 CKAP2

2.71e-05105820926GO:0007017
GeneOntologyBiologicalProcessregulation of organelle organization

NES ILK SPTB SPTBN1 APC2 TRPM2 CUL7 HAUS4 ARHGEF9 ATG5 ROCK2 NPR2 TBC1D30 SYNE1 ARFGEF1 UFL1 GRIK5 TEX14 LCP1 OPA1 TBC1D10B XIRP2 TLR2 CEP135 DAAM2 ROCK1 RIMS1 CKAP2 RIMS2 SLX4

3.73e-05134220930GO:0033043
GeneOntologyBiologicalProcesspeptidyl-threonine modification

GALNT1 GALNT2 GALNT3 GCG ROCK2 CAD ROCK1 PRKDC

4.15e-051252098GO:0018210
GeneOntologyBiologicalProcessmicrotubule-based movement

IFT172 STARD7 BLOC1S1 MAPK8IP3 DST CFAP206 DNAH5 ATG5 KIF13B DNAH3 DNAH2 OPA1 DNAH1 WDR19 LRPPRC TTC29

4.56e-0549320916GO:0007018
GeneOntologyBiologicalProcessplasma membrane bounded cell projection assembly

IFT172 TRPM2 FGD1 CFAP206 DNAH5 PLS1 ATG5 TBC1D30 SYNE1 DNAH2 BBS5 RFX4 DNAH1 WDR19 TBC1D10B CCDC42 CEP135 DAAM2 ROCK1

5.52e-0567020919GO:0120031
GeneOntologyBiologicalProcessmicrotubule-based transport

IFT172 STARD7 BLOC1S1 MAPK8IP3 DST DNAH5 ATG5 OPA1 DNAH1 WDR19 LRPPRC

5.74e-0525320911GO:0099111
GeneOntologyBiologicalProcessregulation of anatomical structure size

ILK SPTB SPTBN1 BLOC1S1 ITGA1 PEX11B RYK PLEKHA7 PLS1 ATG5 ROCK2 DIP2B ARFGEF1 TLR2 MACF1 DAAM2 ROCK1 PDE5A

6.21e-0561820918GO:0090066
GeneOntologyBiologicalProcesscell projection assembly

IFT172 TRPM2 FGD1 CFAP206 DNAH5 PLS1 ATG5 TBC1D30 SYNE1 DNAH2 BBS5 RFX4 DNAH1 WDR19 TBC1D10B CCDC42 CEP135 DAAM2 ROCK1

7.40e-0568520919GO:0030031
GeneOntologyBiologicalProcesscell projection morphogenesis

NES ILK ITGA1 CUL7 RYK MAPK8IP3 DST ROCK2 KIF13B DIP2B NPR2 SYNE1 SPAG9 OPA1 GDF7 FARP1 MACF1 ROCK1 RIMS1 RIMS2 TOP2B

1.06e-0482620921GO:0048858
GeneOntologyBiologicalProcesscilium organization

IFT172 CFAP206 DNAH5 ATG5 TBC1D30 SYNE1 DNAH2 BBS5 RFX4 DNAH1 WDR19 TBC1D10B CCDC42 TTC29 CEP135

1.10e-0447620915GO:0044782
GeneOntologyBiologicalProcessprotein O-linked glycosylation via serine

GALNT1 GALNT2 GALNT3

1.17e-04102093GO:0018242
GeneOntologyBiologicalProcessprotein O-linked glycosylation via threonine

GALNT1 GALNT2 GALNT3

1.17e-04102093GO:0018243
GeneOntologyBiologicalProcessactin filament network formation

PLS1 PLS3 LCP1

1.59e-04112093GO:0051639
GeneOntologyBiologicalProcesscilium assembly

IFT172 CFAP206 DNAH5 ATG5 TBC1D30 SYNE1 DNAH2 BBS5 RFX4 DNAH1 WDR19 TBC1D10B CCDC42 CEP135

1.85e-0444420914GO:0060271
GeneOntologyBiologicalProcesscell morphogenesis

NES ILK ITGA1 CUL7 RYK MAPK8IP3 DST FGD1 PLS1 BRWD1 ROCK2 KIF13B DIP2B NPR2 SYNE1 SPAG9 OPA1 WDR19 GDF7 FARP1 MACF1 ROCK1 RIMS1 PRKDC RIMS2 TOP2B

1.95e-04119420926GO:0000902
GeneOntologyBiologicalProcessneuron projection morphogenesis

ILK ITGA1 CUL7 RYK MAPK8IP3 DST ROCK2 KIF13B DIP2B NPR2 SYNE1 SPAG9 OPA1 GDF7 FARP1 MACF1 ROCK1 RIMS1 RIMS2 TOP2B

2.00e-0480220920GO:0048812
GeneOntologyCellularComponentcytoplasmic region

IFT172 BLOC1S1 MAPK8IP3 DST PIK3C3 CFAP206 DNAH5 BRWD1 ATG5 DNAH3 DNAH2 ARFGEF2 BBS5 OPA1 DNAH1 EFHC2 RIMS1 RIMS2

3.35e-0836021318GO:0099568
GeneOntologyCellularComponentplasma membrane bounded cell projection cytoplasm

IFT172 BLOC1S1 MAPK8IP3 DST PIK3C3 CFAP206 DNAH5 BRWD1 ATG5 DNAH3 DNAH2 ARFGEF2 BBS5 OPA1 DNAH1 EFHC2

1.75e-0731721316GO:0032838
GeneOntologyCellularComponentaxoneme

IFT172 PIK3C3 CFAP206 DNAH5 BRWD1 ATG5 DNAH3 DNAH2 ARFGEF2 BBS5 DNAH1 EFHC2

1.51e-0620721312GO:0005930
GeneOntologyCellularComponentciliary plasm

IFT172 PIK3C3 CFAP206 DNAH5 BRWD1 ATG5 DNAH3 DNAH2 ARFGEF2 BBS5 DNAH1 EFHC2

1.58e-0620821312GO:0097014
GeneOntologyCellularComponentsupramolecular fiber

NES PDE4B ILK SPTBN1 APC2 HAUS4 DST CFAP206 DNAH5 PLS1 PLS3 KIF13B DNAH3 VPS18 KRT13 KRT16 KRT32 SYNE1 DNAH2 ARFGEF2 LCP1 OPA1 DNAH1 EFHC2 LRPPRC XIRP2 RTL1 MACF1 CKAP2

9.88e-06117921329GO:0099512
GeneOntologyCellularComponentsupramolecular polymer

NES PDE4B ILK SPTBN1 APC2 HAUS4 DST CFAP206 DNAH5 PLS1 PLS3 KIF13B DNAH3 VPS18 KRT13 KRT16 KRT32 SYNE1 DNAH2 ARFGEF2 LCP1 OPA1 DNAH1 EFHC2 LRPPRC XIRP2 RTL1 MACF1 CKAP2

1.12e-05118721329GO:0099081
GeneOntologyCellularComponentpolymeric cytoskeletal fiber

NES APC2 HAUS4 DST CFAP206 DNAH5 PLS1 PLS3 KIF13B DNAH3 VPS18 KRT13 KRT16 KRT32 DNAH2 ARFGEF2 LCP1 OPA1 DNAH1 EFHC2 LRPPRC MACF1 CKAP2

4.87e-0589921323GO:0099513
GeneOntologyCellularComponentaxonemal dynein complex

DNAH5 DNAH3 DNAH2 DNAH1

1.12e-04252134GO:0005858
GeneOntologyCellularComponentinner dynein arm

DNAH3 DNAH2 DNAH1

1.19e-04102133GO:0036156
GeneOntologyCellularComponentmicrotubule

APC2 HAUS4 DST CFAP206 DNAH5 KIF13B DNAH3 DNAH2 ARFGEF2 OPA1 DNAH1 EFHC2 LRPPRC MACF1 CKAP2

3.93e-0453321315GO:0005874
GeneOntologyCellularComponentactin cytoskeleton

ILK ACACA SPTB SPTBN1 APC2 DHX9 NPFFR2 DST PLS1 PLS3 CCDC102A VPS18 LCP1 XIRP2 MACF1

8.71e-0457621315GO:0015629
GeneOntologyCellularComponentmotile cilium

IFT172 CFAP206 DNAH5 BRWD1 NPHP1 DNAH3 DNAH2 DNAH1 WDR19 CCDC42 TTC29

1.09e-0335521311GO:0031514
DomainACTININ_2

SPTB SPTBN1 DST UTRN PLS1 PLS3 SYNE1 LCP1 MACF1

1.80e-12232119PS00020
DomainACTININ_1

SPTB SPTBN1 DST UTRN PLS1 PLS3 SYNE1 LCP1 MACF1

1.80e-12232119PS00019
DomainActinin_actin-bd_CS

SPTB SPTBN1 DST UTRN PLS1 PLS3 SYNE1 LCP1 MACF1

1.80e-12232119IPR001589
DomainCH

SPTB SPTBN1 DST MICAL3 UTRN PLS1 PLS3 SYNE1 LCP1 MACF1

2.85e-096521110SM00033
DomainCH

SPTB SPTBN1 DST MICAL3 UTRN PLS1 PLS3 SYNE1 LCP1 MACF1

6.01e-097021110PF00307
Domain-

SPTB SPTBN1 DST MICAL3 UTRN PLS1 PLS3 SYNE1 LCP1 MACF1

6.93e-0971211101.10.418.10
DomainCH

SPTB SPTBN1 DST MICAL3 UTRN PLS1 PLS3 SYNE1 LCP1 MACF1

9.15e-097321110PS50021
DomainCH-domain

SPTB SPTBN1 DST MICAL3 UTRN PLS1 PLS3 SYNE1 LCP1 MACF1

1.20e-087521110IPR001715
DomainSpectrin

SPTB SPTBN1 DST UTRN SYNE1 MACF1

1.67e-07232116PF00435
DomainSpectrin_repeat

SPTB SPTBN1 DST UTRN SYNE1 MACF1

7.40e-07292116IPR002017
DomainSPEC

SPTB SPTBN1 DST UTRN SYNE1 MACF1

1.37e-06322116SM00150
DomainSpectrin/alpha-actinin

SPTB SPTBN1 DST UTRN SYNE1 MACF1

1.37e-06322116IPR018159
DomainDCB_dom

ARFGEF2 ARFGEF1 ARFGEF3

5.64e-0642113IPR032629
DomainSec7_C

ARFGEF2 ARFGEF1 ARFGEF3

5.64e-0642113IPR015403
DomainDUF1981

ARFGEF2 ARFGEF1 ARFGEF3

5.64e-0642113PF09324
DomainDCB

ARFGEF2 ARFGEF1 ARFGEF3

5.64e-0642113PF16213
DomainDynein_heavy_chain_D4_dom

DNAH5 DNAH3 DNAH2 DNAH1

1.45e-05142114IPR024317
DomainDynein_HC_stalk

DNAH5 DNAH3 DNAH2 DNAH1

1.45e-05142114IPR024743
DomainDynein_heavy_dom-2

DNAH5 DNAH3 DNAH2 DNAH1

1.45e-05142114IPR013602
DomainDHC_N2

DNAH5 DNAH3 DNAH2 DNAH1

1.45e-05142114PF08393
DomainATPase_dyneun-rel_AAA

DNAH5 DNAH3 DNAH2 DNAH1

1.45e-05142114IPR011704
DomainMT

DNAH5 DNAH3 DNAH2 DNAH1

1.45e-05142114PF12777
DomainAAA_8

DNAH5 DNAH3 DNAH2 DNAH1

1.45e-05142114PF12780
DomainAAA_5

DNAH5 DNAH3 DNAH2 DNAH1

1.45e-05142114PF07728
DomainDHC_fam

DNAH5 DNAH3 DNAH2 DNAH1

1.96e-05152114IPR026983
DomainCAP

CLEC18A CLEC18B CLEC18C GLIPR1L2

1.96e-05152114PF00188
DomainSCP

CLEC18A CLEC18B CLEC18C GLIPR1L2

1.96e-05152114SM00198
DomainAllrgn_V5/Tpx1

CLEC18A CLEC18B CLEC18C GLIPR1L2

1.96e-05152114IPR001283
DomainDynein_heavy

DNAH5 DNAH3 DNAH2 DNAH1

1.96e-05152114PF03028
Domain-

CLEC18A CLEC18B CLEC18C GLIPR1L2

1.96e-051521143.40.33.10
DomainDynein_heavy_dom

DNAH5 DNAH3 DNAH2 DNAH1

1.96e-05152114IPR004273
DomainCAP_domain

CLEC18A CLEC18B CLEC18C GLIPR1L2

1.96e-05152114IPR014044
DomainRho_Binding

ROCK2 ROCK1

1.27e-0422112PF08912
DomainRho-bd_dom

ROCK2 ROCK1

1.27e-0422112IPR015008
DomainJIP_LZII

MAPK8IP3 SPAG9

1.27e-0422112IPR032486
DomainROCK1/ROCK2

ROCK2 ROCK1

1.27e-0422112IPR020684
DomainJIP_LZII

MAPK8IP3 SPAG9

1.27e-0422112PF16471
DomainARM-type_fold

IFT172 APC2 CUL7 PIK3C3 ANKAR NIPBL DOCK2 ARFGEF2 ARFGEF1 ARFGEF3 PPP2R1A DAAM2 PRKDC

1.33e-0433921113IPR016024
DomainRicin_B_lectin

GALNT1 GALNT2 GALNT3 GALNT12

1.66e-04252114PF00652
DomainRICIN

GALNT1 GALNT2 GALNT3 GALNT12

2.62e-04282114SM00458
DomainRICIN_B_LECTIN

GALNT1 GALNT2 GALNT3 GALNT12

2.62e-04282114PS50231
DomainPH

SPTBN1 ARHGEF9 FGD1 PLEKHA7 ROCK2 ADAP1 ARAP3 FARP1 ROCK1 PLEKHM3

2.87e-0422921110PF00169
DomainEF-hand_1

DUOX1 DST PLS1 PLS3 LCP1 PPEF1 EFHC2 MACF1

3.39e-041522118PF00036
DomainRicin_B_lectin

GALNT1 GALNT2 GALNT3 GALNT12

3.45e-04302114IPR000772
DomainGlycos_transf_2

GALNT1 GALNT2 GALNT3 GALNT12

3.45e-04302114PF00535
DomainGlyco_trans_2-like

GALNT1 GALNT2 GALNT3 GALNT12

3.45e-04302114IPR001173
DomainEF-hand_7

DST PLS1 PLS3 LCP1 PPEF1 MACF1

4.03e-04852116PF13499
Domain-

SPTBN1 RABGAP1L ARHGEF9 FGD1 PLEKHA7 ROCK2 ADAP1 BBS5 MTMR4 ARAP3 FARP1 ROCK1 PLEKHM3

5.26e-04391211132.30.29.30
DomainZnf_FYVE-rel

FGD1 MTMR4 RIMS1 RIMS2

5.63e-04342114IPR017455
DomainTPR_REGION

ERCC6L IFT172 TTC7B NAA15 DNAH2 WDR19 TTC29 PRKDC

5.86e-041652118PS50293
DomainTPR

ERCC6L IFT172 TTC7B NAA15 DNAH2 WDR19 TTC29 PRKDC

5.86e-041652118PS50005
DomainSEC7

ARFGEF2 ARFGEF1 ARFGEF3

7.14e-04162113PS50190
DomainSec7

ARFGEF2 ARFGEF1 ARFGEF3

7.14e-04162113SM00222
DomainSec7_dom

ARFGEF2 ARFGEF1 ARFGEF3

7.14e-04162113IPR000904
Domain-

GTF2IRD2 GTF2IRD2B

7.51e-04421123.90.1460.10
DomainVDCC_a2/dsu

CACNA2D2 CACNA2D4

7.51e-0442112IPR013680
DomainPecanex_C

PCNX2 PCNX1

7.51e-0442112PF05041
DomainJNK/Rab-associated_protein-1_N

MAPK8IP3 SPAG9

7.51e-0442112IPR019143
DomainSpectrin_bsu

SPTB SPTBN1

7.51e-0442112IPR016343
DomainVGCC_alpha2

CACNA2D2 CACNA2D4

7.51e-0442112PF08473
DomainJnk-SapK_ap_N

MAPK8IP3 SPAG9

7.51e-0442112PF09744
DomainSec7_N

ARFGEF2 ARFGEF1

7.51e-0442112IPR032691
DomainGTF2I

GTF2IRD2 GTF2IRD2B

7.51e-0442112PS51139
DomainSec7_N

ARFGEF2 ARFGEF1

7.51e-0442112PF12783
DomainGTF2I

GTF2IRD2 GTF2IRD2B

7.51e-0442112PF02946
DomainPecanex

PCNX2 PCNX1

7.51e-0442112IPR007735
DomainGTF2I

GTF2IRD2 GTF2IRD2B

7.51e-0442112IPR004212
Domain-

DUOX1 DST SPARCL1 UTRN PLS1 PLS3 LCP1 PPEF1 EFHC2 MACF1

7.97e-04261211101.10.238.10
DomainEF_Hand_1_Ca_BS

DUOX1 DST SPARCL1 PLS1 PLS3 LCP1 PPEF1 MACF1

8.61e-041752118IPR018247
DomainZnf_FYVE

FGD1 MTMR4 RIMS1 RIMS2

8.65e-04382114IPR000306
Domain-

APC2 CUL7 ANKAR NIPBL ARFGEF2 ARFGEF1 PPP2R1A DAAM2 PRKDC

9.76e-0422221191.25.10.10
DomainARM-like

APC2 CUL7 ANKAR NIPBL DOCK2 ARFGEF2 ARFGEF1 PPP2R1A DAAM2 PRKDC

1.03e-0327021110IPR011989
DomainZF_FYVE

FGD1 MTMR4 RIMS1 RIMS2

1.05e-03402114PS50178
DomainPH_dom-like

SPTBN1 RABGAP1L ARHGEF9 FGD1 PLEKHA7 ROCK2 ADAP1 BBS5 MTMR4 ARAP3 FARP1 ROCK1 PLEKHM3

1.16e-0342621113IPR011993
DomainVWA_N

CACNA2D2 CACNA2D4

1.24e-0352112IPR013608
DomainVWA_N

CACNA2D2 CACNA2D4

1.24e-0352112PF08399
DomainCPSASE_1

ACACA CAD

1.24e-0352112PS00866
DomainRH2

MAPK8IP3 SPAG9

1.24e-0352112PS51777
DomainRH1

MAPK8IP3 SPAG9

1.24e-0352112PS51776
DomainPH

SPTBN1 ARHGEF9 FGD1 PLEKHA7 ROCK2 ADAP1 ARAP3 FARP1 ROCK1 PLEKHM3

1.28e-0327821110SM00233
DomainEF_HAND_2

DUOX1 DST SPARCL1 PLS1 PLS3 LCP1 PPEF1 EFHC2 MACF1

1.29e-032312119PS50222
DomainPH_DOMAIN

SPTBN1 ARHGEF9 FGD1 PLEKHA7 ROCK2 ADAP1 ARAP3 FARP1 ROCK1 PLEKHM3

1.32e-0327921110PS50003
DomainEF_hand_dom

DUOX1 DST SPARCL1 PLS1 PLS3 LCP1 PPEF1 EFHC2 MACF1

1.33e-032322119IPR002048
DomainPH_domain

SPTBN1 ARHGEF9 FGD1 PLEKHA7 ROCK2 ADAP1 ARAP3 FARP1 ROCK1 PLEKHM3

1.35e-0328021110IPR001849
DomainTPR-like_helical_dom

ERCC6L IFT172 CRNKL1 TTC7B NAA15 WDR19 LRPPRC TTC29 PRKDC

1.37e-032332119IPR011990
DomainTPR-contain_dom

ERCC6L CRNKL1 TTC7B NAA15 WDR19 TTC29 PRKDC

1.60e-031502117IPR013026
DomainEF-hand-dom_pair

DUOX1 DST SPARCL1 UTRN PLS1 PLS3 LCP1 PPEF1 EFHC2 MACF1

1.63e-0328721110IPR011992
Domain-

DST MACF1

1.85e-03621123.90.1290.10
DomainGAR

DST MACF1

1.85e-0362112PS51460
DomainGAS2

DST MACF1

1.85e-0362112PF02187
DomainKinesin-like

RABGAP1L KIF13B

1.85e-0362112IPR022164
DomainCPSASE_2

ACACA CAD

1.85e-0362112PS00867
Domain-

DST MACF1

1.85e-03621123.30.920.20
DomainDUF3694

RABGAP1L KIF13B

1.85e-0362112PF12473
DomainGAS_dom

DST MACF1

1.85e-0362112IPR003108
DomainGAS2

DST MACF1

1.85e-0362112SM00243
Domain-

PDE4B TBC1D10B PDE5A

1.87e-032221131.10.1300.10
DomainPDEase_catalytic_dom

PDE4B TBC1D10B PDE5A

2.13e-03232113IPR002073
DomainEFh

DUOX1 DST PLS1 PLS3 LCP1 PPEF1 MACF1

2.15e-031582117SM00054
DomainEF_HAND_1

DUOX1 DST SPARCL1 PLS1 PLS3 LCP1 PPEF1 MACF1

2.28e-032042118PS00018
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

NES ILK ACACA ERCC6L SPTBN1 EDC4 DST PIK3C3 RABGAP1L PLEKHA7 UTRN CCDC102A KIF13B DIP2B NAA15 SH3RF1 KDM5A WDR59 ARFGEF3 LRPPRC TBC1D10B MTMR4 MACF1 PLEKHM3 CKAP2

2.19e-108612172536931259
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

ZNF133 GALNT2 IFT172 SPTB SPTBN1 APC2 SRPK2 ARMCX4 MAPK8IP3 CRNKL1 DST TTC7B PKM KCNN1 SPARCL1 UTRN NIPBL IMMT BRWD1 ATG5 KDM5A SYNE1 ARFGEF2 WDR59 WDR19 MACF1 DAAM2 PRKDC CKAP2 SLX4

5.72e-1012852173035914814
Pubmed

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.

NES TRAF3 PDE4B SPTBN1 APC2 SRPK2 ARMCX4 EDC4 MAPK8IP3 DST NIPBL ROCK2 KIF13B DIP2B CAD KDM5A SYNE1 GRIK5 OPA1 PPP2R1A LRPPRC FARP1 MACF1 ROCK1 RIMS1

2.15e-099632172528671696
Pubmed

The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation.

ACACA ACADM ERCC6L IFT172 SPTBN1 EDC4 DHX9 CRNKL1 SNRNP40 PKM IMMT PLS3 CAD NAA15 UFL1 SPAG9 PPP2R1A LRPPRC PRKDC TOP2B

4.30e-096382172033239621
Pubmed

Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.

NES ACACA SPTBN1 NOL6 CUL7 EDC4 CRNKL1 DST ATAD2B UTRN NIPBL IMMT CAD NAA15 SPAG9 LCP1 PPP2R1A LRPPRC MACF1 PRKDC

6.36e-096532172022586326
Pubmed

KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.

NES SPTB SPTBN1 PHYHIP SRPK2 EDC4 MAPK8IP3 DHX9 DST TTC7B PKM MICAL3 PLEKHA7 UTRN IMMT PLS3 ROCK2 VPS18 CAD KRT16 RCHY1 SYNE1 ARFGEF2 OPA1 SACM1L PPP2R1A LRPPRC FARP1 MACF1 RIMS1

6.82e-0914312173037142655
Pubmed

Identifying biological pathways that underlie primordial short stature using network analysis.

NES GALNT2 NOL6 CUL7 EDC4 DHX9 CRNKL1 RAB9A DST SNRNP40 PKM UTRN NIPBL IMMT CAD KRT16 DSG1 SYNE1 UFL1 PPP2R1A LRPPRC MACF1 PRKDC TOP2B

3.22e-0810242172424711643
Pubmed

Disrupted in Schizophrenia 1 Interactome: evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia.

PDE4B SPTBN1 DST SPARCL1 UTRN IMMT SYNE1 XPNPEP1 BRF1 MACF1

4.23e-081512171017043677
Pubmed

Loss of ER retention motif of AGR2 can impact mTORC signaling and promote cancer metastasis.

ACACA SPTBN1 EDC4 DHX9 DUOX1 DST PKM UTRN IMMT DOCK2 CAD KRT32 SYNE1 XPNPEP1 DNAH1 PPP2R1A LRPPRC MACF1 DAAM2 PCNX1 PRKDC

4.32e-088072172130575818
Pubmed

Isolation of several human axonemal dynein heavy chain genes: genomic structure of the catalytic site, phylogenetic analysis and chromosomal assignment.

DNAH5 DNAH3 DNAH2 DNAH1

5.08e-08721749256245
Pubmed

Organization of focal adhesion plaques is disrupted by action of the HIV-1 protease.

SPTB SPTBN1 PLS1 PLS3 LCP1

7.24e-0818217512119179
Pubmed

Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.

ACACA CACNA2D2 SPTBN1 NOL6 EDC4 DHX9 CRNKL1 RAB9A SNRNP40 PKM PLEKHA7 DNAH5 NIPBL IMMT PLS3 SDHB MGAM2 CAD DSG1 SYNE1 UFL1 OPA1 SACM1L PPP2R1A LRPPRC PRKDC TAF5L TOP2B

8.80e-0814252172830948266
Pubmed

MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.

NES SPTBN1 DHX9 CRNKL1 DST SNRNP40 PKM NIPBL DIP2B CAD KRT16 KDM5A SYNE1 UFL1 OPA1 SACM1L LRPPRC TBC1D10B FARP1 MACF1 PRKDC TAF5L TNXB TOP2B

8.94e-0810822172438697112
Pubmed

In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.

SPTBN1 NOL6 ACSM3 DST GTF2IRD2 PKM NIPBL IMMT PLS1 ROCK2 KIF13B KRT13 ADAP1 KRT16 KDM5A SYNE1 DNAH2 TEX14 LCP1 LRPPRC GTF2IRD2B SNX25 MACF1 RIMS1 PRKDC RIMS2 PCK1 TOP2B

1.12e-0714422172835575683
Pubmed

BioID-based intact cell interactome of the Kv1.3 potassium channel identifies a Kv1.3-STAT3-p53 cellular signaling pathway.

ERCC6L SPTBN1 DHX9 DST PKM MICAL3 IMMT PLS3 ROCK2 CAD SH3RF1 XPNPEP1 OPA1 PPP2R1A LRPPRC TBC1D10B MACF1 ROCK1 PRKDC

1.22e-077082171939231216
Pubmed

Analysis of interaction partners for eukaryotic translation elongation factor 1A M-domain by functional proteomics.

IFT172 DST SYNE1 XIRP2 MACF1

1.30e-0720217521689717
Pubmed

LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.

GALNT1 GALNT2 ERCC6L EDC4 PEX11B FANCA IMMT C8orf33 NAA15 DNAH2 ARFGEF1 GALNT12 UFL1 OPA1 URGCP SACM1L ARFGEF3 PPP2R1A LRPPRC TBC1D10B TMEM209 PRKDC

1.33e-079422172231073040
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

ZNF133 GALNT2 ACACA CACNA2D2 SPTB TRPM2 SRPK2 MAPK8IP3 ZNF461 PCNX2 PIK3C3 ANKAR ARHGEF9 MICAL3 ANKRD12 ZSWIM4 UTRN DIP2B WWP1 POMT1 DNAH1 ARFGEF3 LRPPRC FARP1 MACF1 RIMS1 GREB1 CKAP2

2.15e-0714892172828611215
Pubmed

The Roles of Actin-Binding Domains 1 and 2 in the Calcium-Dependent Regulation of Actin Filament Bundling by Human Plastins.

PLS1 PLS3 LCP1

2.40e-073217328694070
Pubmed

Human plastin genes. Comparative gene structure, chromosome location, and differential expression in normal and neoplastic cells.

PLS1 PLS3 LCP1

2.40e-07321738428952
Pubmed

cDNA cloning and expression of a novel human UDP-N-acetyl-alpha-D-galactosamine. Polypeptide N-acetylgalactosaminyltransferase, GalNAc-t3.

GALNT1 GALNT2 GALNT3

2.40e-07321738663203
Pubmed

Molecular cloning and characterization of plastin, a human leukocyte protein expressed in transformed human fibroblasts.

PLS1 PLS3 LCP1

2.40e-07321733211125
Pubmed

The C-type lectin-like domain superfamily.

CLEC18A CLEC18B CLEC18C

2.40e-073217316336259
Pubmed

Endosomal TLR3 co-receptor CLEC18A enhances host immune response to viral infection.

CLEC18A CLEC18B CLEC18C

2.40e-073217333603190
Pubmed

Critical role of JSAP1 and JLP in axonal transport in the cerebellar Purkinje cells of mice.

MAPK8IP3 ATG5 SPAG9

2.40e-073217326320416
Pubmed

Human CLEC18 Gene Cluster Contains C-type Lectins with Differential Glycan-binding Specificity.

CLEC18A CLEC18B CLEC18C

2.40e-073217326170455
Pubmed

Sequential expression and differential localization of I-, L-, and T-fimbrin during differentiation of the mouse intestine and yolk sac.

PLS1 PLS3 LCP1

2.40e-07321737655078
Pubmed

Localization of three human polypeptide GalNAc-transferases in HeLa cells suggests initiation of O-linked glycosylation throughout the Golgi apparatus.

GALNT1 GALNT2 GALNT3

2.40e-07321739394011
Pubmed

The HIV-1 Tat protein recruits a ubiquitin ligase to reorganize the 7SK snRNP for transcriptional activation.

ACADM EDC4 DHX9 BLK RABGAP1L GTF2IRD2 PKM IMMT PLS1 PLS3 C8orf33 KRT13 CAD KRT16 DSG1 KDM5A KRT32 LCP1 PPP2R1A LRPPRC GTF2IRD2B MACF1 PRKDC TGS1

2.84e-0711532172429845934
Pubmed

Two-Dimensional Fractionation Method for Proteome-Wide Cross-Linking Mass Spectrometry Analysis.

SPTBN1 SRPK2 RABGAP1L SNRNP40 UTRN NIPBL IMMT PLS3 SDHB BRWD1 ROCK2 DNAH3 NAA15 DNAH2 LCP1 PPP2R1A TBC1D10B MACF1 ROCK1 PRKDC

4.28e-078472172035235311
Pubmed

A Multipronged Unbiased Strategy Guides the Development of an Anti-EGFR/EPHA2-Bispecific Antibody for Combination Cancer Therapy.

ACACA DST TTC7B MICAL3 PLEKHA7 UTRN NPHP1 ROCK2 UFL1 OPA1 LRPPRC TBC1D10B MACF1 ROCK1

4.85e-074212171436976175
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

CUL7 DISP3 MICAL3 DOCK2 ROCK2 KIF13B VPS18 SH3RF1 TBC1D30 ZFP30 SPAG9 WDR59 CEP135 MACF1 SLX4

5.77e-074932171515368895
Pubmed

Assembly of the U5 snRNP component PRPF8 is controlled by the HSP90/R2TP chaperones.

ILK ACACA SPTBN1 SRPK2 STARD7 DHX9 CRNKL1 SNRNP40 PKM NIPBL IMMT PLS3 SDHB ROCK2 KRT13 CAD NAA15 KRT16 DSG1 UFL1 OPA1 PPP2R1A LRPPRC MACF1 PRKDC TOP2B

9.35e-0714152172628515276
Pubmed

Microglia/macrophage-specific protein Iba1 binds to fimbrin and enhances its actin-bundling activity.

PLS1 PLS3 LCP1

9.54e-074217314756805
Pubmed

Differential localization of villin and fimbrin during development of the mouse visceral endoderm and intestinal epithelium.

PLS1 PLS3 LCP1

9.54e-07421732686960
Pubmed

The mannose receptor mediates uptake of soluble but not of cell-associated antigen for cross-presentation.

CLEC18A CLEC18B CLEC18C

9.54e-074217316709836
Pubmed

Genomic organization and chromosomal localization of three members of the UDP-N-acetylgalactosamine: polypeptide N-acetylgalactosaminyltransferase family.

GALNT1 GALNT2 GALNT3

9.54e-07421739592121
Pubmed

Proteomic analysis of exosomes from human neural stem cells by flow field-flow fractionation and nanoflow liquid chromatography-tandem mass spectrometry.

PLVAP GALNT3 TEX14 DAAM2 GREB1 RIMS2

1.24e-0655217618570454
Pubmed

Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.

NES ILK ACACA SPTBN1 NOL6 DHX9 CRNKL1 DST SNRNP40 PKM UTRN NIPBL IMMT ATG5 CAD NAA15 DSG1 OAS3 WDR59 PPP2R1A LRPPRC ARAP3 MACF1 PRKDC TOP2B

1.39e-0613532172529467282
Pubmed

Identification of dynein heavy chain genes expressed in human and mouse testis: chromosomal localization of an axonemal dynein gene.

DNAH5 DNAH3 DNAH2 DNAH1

1.41e-061421749373155
Pubmed

Large-scale characterization of HeLa cell nuclear phosphoproteins.

ACACA ERCC6L SPTBN1 MAPK8IP3 DHX9 MICAL3 NIPBL ROCK2 DIP2B KDM5A ARFGEF2 UFL1 SPAG9 URGCP TBC1D10B RIMS1 PRKDC TOP2B

2.05e-067742171815302935
Pubmed

PINK1 Content in Mitochondria is Regulated by ER-Associated Degradation.

ACACA SPTBN1 DHX9 CRNKL1 DST PKM PLS3 CAD DSG1 SPAG9 OPA1 PPP2R1A LRPPRC PRKDC

2.11e-064772171431300519
Pubmed

The cell-layer- and cell-type-specific distribution of GalNAc-transferases in the ocular surface epithelia is altered during keratinization.

GALNT1 GALNT2 GALNT3

2.37e-065217312506059
Pubmed

cDNA cloning and expression of a novel UDP-N-acetyl-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase.

GALNT1 GALNT2 GALNT3

2.37e-06521739153242
Pubmed

Substrate specificities of three members of the human UDP-N-acetyl-alpha-D-galactosamine:Polypeptide N-acetylgalactosaminyltransferase family, GalNAc-T1, -T2, and -T3.

GALNT1 GALNT2 GALNT3

2.37e-06521739295285
Pubmed

Integrin-linked kinase phosphorylates the myosin phosphatase target subunit at the inhibitory site in platelet cytoskeleton.

ILK ROCK2 ROCK1

2.37e-065217311931630
Pubmed

E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.

ACACA DHX9 FANCA DST ALDH16A1 ATAD2B PKM UTRN PLS1 DNAH3 TBC1D30 DNAH2 SPAG9 GRIK5 LOXHD1 GLIPR1L2 PRKDC

4.35e-067362171729676528
Pubmed

Long-term potentiation modulates synaptic phosphorylation networks and reshapes the structure of the postsynaptic interactome.

TRAF3 PDE4B SPTBN1 ROCK2 DIP2B SYNE1 GRIK5 LRPPRC FARP1 MACF1

4.49e-062512171027507650
Pubmed

Morphogenesis of the telencephalic commissure requires scaffold protein JNK-interacting protein 3 (JIP3).

MAPK8IP3 ROCK2 SPAG9 ROCK1

6.60e-0620217412897243
Pubmed

Overexpression of Galnt3 in chondrocytes resulted in dwarfism due to the increase of mucin-type O-glycans and reduction of glycosaminoglycans.

GALNT1 GALNT2 GALNT3 GALNT12

9.87e-0622217425107907
Pubmed

Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics.

IFT172 SPTBN1 DHX9 TTC7B PKM IMMT DIP2B NAA15 DSG1 UFL1 PPP2R1A TBC1D10B TOP2B

1.03e-054752171331040226
Pubmed

Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.

ACACA ACADM SPTBN1 EDC4 MAPK8IP3 RABGAP1L PKM SPARCL1 SDHB CAD NAA15 DSG1 NFS1 OPA1 SACM1L ARFGEF3 LRPPRC FARP1 SNX25 MACF1 RIMS1

1.06e-0511392172136417873
Pubmed

The cell proliferation antigen Ki-67 organises heterochromatin.

TIGD1 SRPK2 DST UTRN NIPBL C8orf33 DNAH3 OAS3 OPA1 NR2F2 PPP2R1A TAF5L

1.17e-054102171226949251
Pubmed

GREB1: An evolutionarily conserved protein with a glycosyltransferase domain links ERα glycosylation and stability to cancer.

SPTBN1 SRPK2 DHX9 IMMT CAD DSG1 PPP2R1A LRPPRC GREB1

1.22e-05223217933731348
Pubmed

A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.

TRAF3 IFT172 UTRN IMMT PLS1 PLS3 SDHB ROCK2 DIP2B NAA15 SPAG9 LCP1 PPEF1 OPA1 PPP2R1A LRPPRC MTMR4 ARAP3 PRKDC

1.31e-059742171928675297
Pubmed

Diverse spatial expression patterns of UDP-GalNAc:polypeptide N-acetylgalactosaminyl-transferase family member mRNAs during mouse development.

GALNT1 GALNT2 GALNT3

1.31e-058217311159923
Pubmed

Inhibition of calpain 1 restores plasma membrane stability to pharmacologically rescued Phe508del-CFTR variant.

ACACA SPTBN1 EDC4 PKM IMMT PLS3 KRT13 KRT16 DSG1 LCP1 PPP2R1A MACF1 PRKDC

1.37e-054882171331324722
Pubmed

Suppression of ACE2 SUMOylation protects against SARS-CoV-2 infection through TOLLIP-mediated selective autophagy.

SPTBN1 DHX9 CRNKL1 PKM IMMT PLS1 C8orf33 CAD KRT16 DSG1 PPP2R1A LRPPRC TBC1D10B PRKDC TOP2B

1.39e-056412171536057605
Pubmed

Galnt11 regulates kidney function by glycosylating the endocytosis receptor megalin to modulate ligand binding.

GALNT1 GALNT2 GALNT3 GALNT12

1.42e-0524217431740596
Pubmed

Loss of the disease-associated glycosyltransferase Galnt3 alters Muc10 glycosylation and the composition of the oral microbiome.

GALNT1 GALNT2 GALNT3 GALNT12

1.42e-0524217431882545
Pubmed

Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.

SPTBN1 NOL6 SRPK2 EDC4 DHX9 CRNKL1 DST SNRNP40 PKM IMMT PLS3 KRT13 CAD NAA15 KRT16 DSG1 PARP2 OAS3 PPP2R1A LRPPRC PRKDC CKAP2

1.44e-0512572172236526897
Pubmed

Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers.

TRAF3 GALNT1 APC2 SRPK2 BLK ACSM3 ECEL1 MMP15 DNAH5 ATP8B3 WWP1 DNAH2 GALNT12 SACM1L MTMR4 TAF5L

1.60e-057302171634857952
Pubmed

A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.

ILK SPTB SPTBN1 DST PKM UTRN KDM5A SYNE1 WWP1 LRPPRC XIRP2 MACF1 TGS1

1.66e-054972171323414517
Pubmed

Fibril treatment changes protein interactions of tau and α-synuclein in human neurons.

NES ILK EDC4 DHX9 DST SNRNP40 ROCK2 DIP2B KRT13 VPS50 PPP2R1A FARP1 MACF1

1.70e-054982171336634849
Pubmed

Large-scale mapping of human protein-protein interactions by mass spectrometry.

ILK ACACA ERCC6L SRPK2 DHX9 PIK3C3 ALDH16A1 SNRNP40 PLS3 ATG5 ROCK2 VPS18 DSG1 KRT32 UFL1 SPAG9 OPA1 PPP2R1A LRPPRC LOXHD1 CEP135 RIMS1

1.99e-0512842172217353931
Pubmed

Network organization of the human autophagy system.

ACACA PIK3C3 RABGAP1L UTRN IMMT ATG5 DIP2B VPS18 NAA15 LRPPRC XIRP2 PRKDC

2.20e-054372171220562859
Pubmed

EGFR suppresses p53 function by promoting p53 binding to DNA-PKcs: a noncanonical regulatory axis between EGFR and wild-type p53 in glioblastoma.

NES SPTBN1 KRT16 DSG1 PRKDC

2.23e-0554217535474131
Pubmed

The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.

GALNT3 PIEZO1 NOL6 SRPK2 EDC4 CRNKL1 DST ARHGEF9 PLEKHA7 UTRN NIPBL IMMT PLS3 C8orf33 CAD TBC1D30 KDM5A SYNE1 PARP2 UFL1 FARP1 MACF1 TAF5L CKAP2

2.42e-0514972172431527615
Pubmed

mTORC2 interactome and localization determine aggressiveness of high-grade glioma cells through association with gelsolin.

ILK SPTBN1 DHX9 PKM CAD NAA15 KRT16 DSG1 LRPPRC PRKDC

2.95e-053122171037120454
Pubmed

ARHGAP24 represses β-catenin transactivation-induced invasiveness in hepatocellular carcinoma mainly by acting as a GTPase-independent scaffold.

PKM IMMT PLS1 PLS3 CAD NAA15 KRT16 WWP1 UFL1 NFS1 OPA1 PPP2R1A

2.99e-054512171236168627
Pubmed

TRIM21 ameliorates hepatic glucose and lipid metabolic disorders in type 2 diabetes mellitus by ubiquitination of PEPCK1 and FASN.

ILK ZSWIM9 ALDH16A1 ARHGEF9 PKM TRPM8 CAD DSG1 LRPPRC LOXHD1 PCK1

3.15e-053822171137249651
Pubmed

Impaired OTUD7A-dependent Ankyrin regulation mediates neuronal dysfunction in mouse and human models of the 15q13.3 microdeletion syndrome.

SPTB SPTBN1 MAPK8IP3 MICAL3 SPAG9 NFS1 ARFGEF3 MACF1

3.59e-05197217836604605
Pubmed

A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.

TRAF3 GALNT2 GALNT3 ACADM SPTBN1 NOL6 EDC4 DST SNRNP40 MICAL3 PLS3 SDHB CAD PARP2 OAS3 UFL1 SACM1L ARFGEF3 PPP2R1A LRPPRC TMEM209 PRKDC TOP2B

3.82e-0514402172330833792
Pubmed

ROCK1 and ROCK2 regulate epithelial polarisation and geometric cell shape.

ROCK2 ROCK1

3.88e-052217222462535
Pubmed

Characterization of interleukin 2 stimulated 65-kilodalton phosphoprotein in human T cells.

PLS1 LCP1

3.88e-05221722111166
Pubmed

Importance of a conserved sequence motif in transmembrane segment S3 for the gating of human TRPM8 and TRPM2.

TRPM2 TRPM8

3.88e-052217223185472
Pubmed

Toll-like receptor signaling in macrophages is regulated by extracellular substrate stiffness and Rho-associated coiled-coil kinase (ROCK1/2).

ROCK2 ROCK1

3.88e-052217229800294
Pubmed

Acf7 (MACF) is an actin and microtubule linker protein whose expression predominates in neural, muscle, and lung development.

DST MACF1

3.88e-052217211002341
Pubmed

Long-term inhibition of Rho-kinase suppresses left ventricular remodeling after myocardial infarction in mice.

ROCK2 ROCK1

3.88e-052217215096457
Pubmed

RIM2α is a molecular scaffold for Zona pellucida-induced acrosome reaction.

RIMS1 RIMS2

3.88e-052217225240052
Pubmed

Rho-kinase/ROCK: A key regulator of the cytoskeleton and cell polarity.

ROCK2 ROCK1

3.88e-052217220803696
Pubmed

The connection between the cardiac glycoside-induced senescent cell morphology and Rho/Rho kinase pathway.

ROCK2 ROCK1

3.88e-052217230369081
Pubmed

Identification of I-plastin, a human fimbrin isoform expressed in intestine and kidney.

PLS1 LCP1

3.88e-05221728139549
Pubmed

Contribution of the S5-pore-S6 domain to the gating characteristics of the cation channels TRPM2 and TRPM8.

TRPM2 TRPM8

3.88e-052217220587417
Pubmed

Rho-associated kinases play an essential role in cardiac morphogenesis and cardiomyocyte proliferation.

ROCK2 ROCK1

3.88e-052217212508221
Pubmed

Overlapping roles of JIP3 and JIP4 in promoting axonal transport of lysosomes in human iPSC-derived neurons.

MAPK8IP3 SPAG9

3.88e-052217233788575
Pubmed

Identification and localization of two brefeldin A-inhibited guanine nucleotide-exchange proteins for ADP-ribosylation factors in a macromolecular complex.

ARFGEF2 ARFGEF1

3.88e-052217210716990
Pubmed

Common variants of ROCKs and the risk of hypertension, and stroke: Two case-control studies and a follow-up study in Chinese Han population.

ROCK2 ROCK1

3.88e-052217229246448
Pubmed

Fibroblast deletion of ROCK2 attenuates cardiac hypertrophy, fibrosis, and diastolic dysfunction.

ROCK2 ROCK1

3.88e-052217228679962
Pubmed

Diverse signaling pathways regulate fibroblast differentiation and transformation through Rho kinase activation.

ROCK2 ROCK1

3.88e-052217217167780
Pubmed

Distinct distribution and localization of Rho-kinase in mouse epithelial, muscle and neural tissues.

ROCK2 ROCK1

3.88e-052217222986902
Pubmed

Distinct roles for ROCK1 and ROCK2 in the regulation of keratinocyte differentiation.

ROCK2 ROCK1

3.88e-052217219997641
Pubmed

Mitochondrial dynamics-related genes DRP1 and OPA1 contributes to early diagnosis of cognitive impairment in diabetes.

UTRN OPA1

3.88e-052217237563583
Pubmed

Role of Rho kinase isoforms in murine allergic airway responses.

ROCK2 ROCK1

3.88e-052217221565918
Pubmed

RIM C2B Domains Target Presynaptic Active Zone Functions to PIP2-Containing Membranes.

RIMS1 RIMS2

3.88e-052217229606581
Pubmed

The Rho kinase pathway regulates mouse adult neural precursor cell migration.

ROCK2 ROCK1

3.88e-052217221732490
Pubmed

Adjustable passive stiffness in mouse bladder: regulated by Rho kinase and elevated following partial bladder outlet obstruction.

ROCK2 ROCK1

3.88e-052217222205227
Pubmed

Redundant roles of BIG2 and BIG1, guanine-nucleotide exchange factors for ADP-ribosylation factors in membrane traffic between the trans-Golgi network and endosomes.

ARFGEF2 ARFGEF1

3.88e-052217218417613
Pubmed

Sulfide induces apoptosis and Rho kinase-dependent cell blebbing in Jurkat cells.

ROCK2 ROCK1

3.88e-052217223479079
Pubmed

Importance of innate immunity and collagen binding integrin alpha1beta1 in TNBS-induced colitis.

ITGA1 PRKDC

3.88e-052217212479823
InteractionECT2 interactions

NES ILK GALNT2 SPTB SPTBN1 NOL6 SRPK2 DHX9 DST SNRNP40 PKM MICAL3 IMMT PLS1 PLS3 ATG5 SPAG9 WDR59 LRPPRC BRF1 FARP1 CEP135 MACF1 PRKDC TOP2B

6.28e-0688721025int:ECT2
InteractionOBSL1 interactions

NES NOL6 CUL7 EDC4 DHX9 FANCA CRNKL1 PRDM11 DST SNRNP40 PKM UTRN NIPBL IMMT MGAM2 CAD KRT16 SYNE1 DNAH1 PPP2R1A MTMR4 TTC29 MACF1 PRKDC TOP2B

8.38e-0690221025int:OBSL1
InteractionMYH9 interactions

ACACA ACADM SPTBN1 BLK DST PIK3C3 MICAL3 DNAH5 IMMT PLS1 CCDC102A OARD1 NPHP1 KIF13B CAD ARFGEF1 UFL1 SPAG9 PPP2R1A LRPPRC CCDC42 MACF1

1.38e-0575421022int:MYH9
InteractionINA interactions

NES CUL7 DHX9 PKM FGD1 ROCK2 DIP2B KRT16 KRT32 CEP135

1.42e-0517321010int:INA
Cytoband19q13.12

ZNF829 ZNF461 ZFP30 ZNF790 ZNF420

2.44e-0572217519q13.12
Cytoband15q14-q15

CCNDBP1 VPS18

2.20e-045217215q14-q15
Cytoband8q11

PRKDC TGS1

3.29e-04621728q11
GeneFamilyPleckstrin homology domain containing|Rho guanine nucleotide exchange factors|C2 domain containing

SPTB SPTBN1 ARHGEF9 FGD1 PLEKHA7 ROCK2 ADAP1 ARAP3 FARP1 ROCK1 PLEKHM3

6.05e-0720614011682
GeneFamilyDyneins, axonemal

DNAH5 DNAH3 DNAH2 DNAH1

7.58e-06171404536
GeneFamilyPolypeptide N-acetylgalactosaminyltransferases

GALNT1 GALNT2 GALNT3 GALNT12

1.52e-05201404433
GeneFamilyEF-hand domain containing

DUOX1 DST PLS1 PLS3 LCP1 PPEF1 EFHC2 MACF1

3.10e-042191408863
GeneFamilyRegulating synaptic membrane exocytosis family|PDZ domain containing

RIMS1 RIMS2

3.54e-0441402833
GeneFamilyEF-hand domain containing|Spectrins

SPTB SPTBN1

1.22e-03714021113
GeneFamilyKeratins, type I

KRT13 KRT16 KRT32

1.29e-03281403608
GeneFamilyEF-hand domain containing|Plakins

DST MACF1

1.62e-0381402939
CoexpressionNIKOLSKY_BREAST_CANCER_19Q13.1_AMPLICON

ZNF829 ZNF461 ZFP30 ZNF790 ZNF420

8.52e-07222165M8692
CoexpressionFLECHNER_BIOPSY_KIDNEY_TRANSPLANT_OK_VS_DONOR_UP

GALNT1 PEX11B RYK DHX9 ACSM3 DST PKM SPARCL1 IMMT PLS3 WWP1 ARFGEF1 UFL1 PPP2R1A MTMR4 ROCK1 PCK1 TOP2B

1.27e-0656821618M4023
CoexpressionLAKE_ADULT_KIDNEY_C26_MESANGIAL_CELLS

SPTBN1 ITGA1 DST ANKRD12 UTRN ROCK2 SYNE1 SPAG9 DAAM2 ROCK1

2.28e-0617721610M39245
ToppCell(03)_KRT6B+-(2)_GFP_FOXI1|(03)_KRT6B+ / shred by cell type by condition

DST ANKRD12 UTRN NIPBL BRWD1 ROCK2 WWP1 ARFGEF1 TLR2 ROCK1

5.34e-0819921710c425e7975f492ed5cfcca022248adb627e1d27d4
ToppCellLPS-IL1RA+antiTNF-Stromal_mesenchymal-Fibroblasts|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

NES PRDM11 ACSM3 DHDH ECEL1 PPEF1 DAAM2 RIMS1 TNXB

8.16e-081572179f086753b51860e23f1275bd75e8802d2a7d7b70a
ToppCell356C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_3|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

CCNDBP1 CACNA2D2 KLHL35 PLEKHA7 BBS5 CSF2RA FARP1 DAAM2 TNXB

9.10e-0815921791472536eea61d4f13033efe42f128bae1614fa74
ToppCellP15-Epithelial-airway_epithelial_cell-ciliated_cell_of_airway|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

GALNT3 GTF2IRD2 CAD GALNT12 GPRC6A GRIK5 WDR19 TMEM209 DAAM2

1.38e-0716721795c3d0763f73628c71c71f9883556bb4f1639f3cc
ToppCellAdult-Epithelial|Adult / Lineage, Cell type, age group and donor

ACACA CACNA2D2 DUOX1 PLEKHA7 DNAH5 SH3RF1 ARFGEF3 FARP1 SNX25

4.51e-071922179efb962a5fd3b9bdfd8cf8d13c435e29c8271713e
ToppCellnucseq-Epithelial|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

ACACA CACNA2D2 DUOX1 DNAH5 SH3RF1 SYNE1 ARFGEF3 FARP1 SNX25

5.13e-0719521799406866f99555198a9be311fbd65751b70f35446
ToppCellfacs-Bladder-nan-3m-Epithelial|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GALNT1 SPTBN1 RYK UTRN PLS3 NR2F2 MACF1 PDE5A TOP2B

5.36e-071962179c0e90d964baa2eb4fbd18a52379ccec5d3bf59a8
ToppCellfacs-Bladder-nan-3m|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GALNT1 SPTBN1 RYK UTRN PLS3 NR2F2 MACF1 PDE5A TOP2B

5.36e-07196217944f5b1b474399c9316729155f2ea95a82ca66e30
ToppCellLPS-IL1RA-Endothelial-Mes-Like-Gen_Cap|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ZNF829 ACSM3 ANKAR KCNN1 KLHDC8B MAMDC4 PDE5A RIMS1

5.82e-07145217890ca38c02325c5c637c32efdef634b54cc3cd105
ToppCellLPS_IL1RA-Endothelial-Endothelial-Gen_Cap|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

SPTBN1 DST SPARCL1 UTRN NIPBL BRWD1 ROCK2 ARAP3 MACF1

6.34e-072002179dccec522ab0d7fff62ad6273b02aa9022dbbb8eb
ToppCellsaliva-Severe-critical_progression_d28-40-Myeloid-Macrophage-macrophage,_alveolar-Macro_c6-VCAN|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)

SPTB KLHL30 KCNN1 IMMT KLHDC8B DNAH3 SACM1L MUTYH

1.22e-0616021788374ae912337947b2cc8d17d5840f306361fe1ff
ToppCell3'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

MAPK8IP3 DUOX1 DNAH5 NPHP1 KIF13B DNAH3 POMT1 C2orf81

2.02e-0617121781854a777d9eb9d3fc3ed3632332a6f89ce8131da
ToppCellPND01-03-samps-Mesenchymal-Matrix_fibroblast-FB-2|PND01-03-samps / Age Group, Lineage, Cell class and subclass

NUGGC ZSWIM9 MICAL3 NPR2 KRT32 NR2F2 MACF1

2.71e-0612521776cd741dd1c7ee6b16437cca7c15c99b5c95603fc
ToppCelldroplet-Marrow-nan-3m|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SPTBN1 DHX9 UTRN NIPBL ROCK2 MACF1 PLEKHM3 TOP2B

3.47e-0618421781154a5ad7b8512272b7476f949ddac350910bfb7
ToppCell3'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-pericyte_cell-Pericytes-Pericytes_L.2.3.3.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

NES ITGA1 SPARCL1 UTRN ROCK2 NR2F2 DAAM2 PDE5A

3.76e-061862178888e85a025bd982d36c910db0f5a3385b1ca3b28
ToppCellControl-Epithelial_cells|Control / group, cell type (main and fine annotations)

CACNA2D2 DUOX1 PLEKHA7 DNAH5 SH3RF1 ARFGEF3 FARP1 SNX25

4.07e-061882178707ebf76cc6fb600b2f07793cf4ea9482c0de79d
ToppCellCiliated-cil-3|World / Class top

IFT172 FANCA CFAP206 DNAH5 DNAH3 SYNE1 DNAH2 DNAH1

4.76e-0619221784989ebb8812b8af1870599acd932849122c05a29
ToppCellnucseq-Epithelial-Epithelial_Alveolar|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

ACACA CACNA2D2 DUOX1 SH3RF1 SYNE1 ARFGEF3 FARP1 SNX25

5.13e-06194217853f3e49e91b1096f3226010e2de767efb490dfe4
ToppCellCOPD-Multiplet|COPD / Disease state, Lineage and Cell class

SPTBN1 DNAH5 DNAH3 SH3RF1 SYNE1 ARFGEF3 TTC29 MACF1

5.53e-0619621786d02d494196e3f857d53eea46d9419690d43beca
ToppCellCOPD-Multiplet-Multiplet|COPD / Disease state, Lineage and Cell class

SPTBN1 DNAH5 DNAH3 SH3RF1 SYNE1 ARFGEF3 TTC29 MACF1

5.53e-061962178af4cdc61830685a888a1209826c23bcf54a43084
ToppCell5'-Airway_Nasal-Epithelial-Airway_ciliated|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

IFT172 DNAH5 NPHP1 DNAH3 SYNE1 DNAH2 EFHC2 TTC29

5.75e-06197217891637bdeab85024b5a02d1066f76cb803a2d6420
ToppCell5'-Airway_Nasal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

IFT172 DNAH5 NPHP1 DNAH3 SYNE1 DNAH2 EFHC2 TTC29

5.75e-06197217822c87dd15dc57bd0aa98a204c9fc9b3b9b573b45
ToppCell5'-Airway_Nasal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.0.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

IFT172 DNAH5 NPHP1 DNAH3 SYNE1 DNAH2 EFHC2 TTC29

5.75e-0619721783bbf068d2ad8196fbc85d3f311a7c54c9aece856
ToppCell5'-Airway_Nasal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

IFT172 DNAH5 NPHP1 DNAH3 SYNE1 DNAH2 EFHC2 TTC29

5.75e-06197217887db09f341e2b20eb6e1c3e917cb5c960387b3e9
ToppCellBronchial-NucSeq-Epithelial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

ACACA CACNA2D2 DUOX1 PLEKHA7 SH3RF1 ARFGEF3 FARP1 SNX25

6.19e-0619921785f7da3eab58ace6cddb3179a415cd839d5767958
ToppCellParenchymal-NucSeq-Epithelial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

ACACA CACNA2D2 DUOX1 PLEKHA7 SH3RF1 ARFGEF3 FARP1 SNX25

6.19e-0619921785cea0d9e261903e0eaad60c28a07dff72ce65027
ToppCell(09)_Interm._secr.>cil.-(2)_GFP_FOXI1|(09)_Interm._secr.>cil. / shred by cell type by condition

GALNT1 SRPK2 ANKRD12 DNAH5 NIPBL NAA15 WWP1 ROCK1

6.19e-061992178fc680f85ebd3bab4c72876a19a461b0afb5f51ce
ToppCellmild|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

ATAD2B ANKRD12 UTRN NIPBL OAS3 SPAG9 MACF1 ROCK1

6.42e-06200217812f1685ce8f218433068e090c9d839cd5a1910bf
ToppCellCOVID-19|World / Disease, condition lineage and cell class

ANKRD12 UTRN NIPBL OAS3 SPAG9 LCP1 MACF1 ROCK1

6.42e-0620021787dec470c379cd89f05a0f37c8628b21f136e52f0
ToppCellfacs-Marrow-Granulocytes-18m-Hematologic|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NUGGC SPTB PHYHIP ARSI ERFE MICAL3 PLS1

1.43e-05161217760f433eab9d5531bdf6aa86b0265f20b866b904c
ToppCellFrontal_cortex-Neuronal-Excitatory-eN1(Slc17a7)-eN1_2-Nptxr-Excitatory_Neuron.Slc17a7.Nptxr-Deptor_(Deep_layer_pyramidal_cells--Layer_5a)|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

CLEC18A NPC1L1 CFAP206 PPEF1 LOXHD1 CCDC42

1.49e-051082176514dfc3f7ac303311ae599f981f3f3c7eb6801b8
ToppCelldroplet-Fat-SCAT-30m-Lymphocytic-nan|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NUGGC BLK PRDM11 KLHL30 RABGAP1L TRPM8 PLS1

1.75e-05166217767370c49d7aedcb4eca802095f06b30f6bbf8919
ToppCelldroplet-Fat-SCAT-30m-Lymphocytic|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NUGGC BLK PRDM11 KLHL30 RABGAP1L TRPM8 PLS1

1.75e-0516621777f4e5976ede6478636aa567d6fc2b56ff7295fb8
ToppCellControl-Stromal-Pericyte|World / Disease state, Lineage and Cell class

NES ITGA1 PNMA6F ECEL1 SPARCL1 NR2F2 DAAM2

2.20e-051722177813d4256b05b66ca11b08cc0026459d79f12c0eb
ToppCelldroplet-Heart-nan-3m|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DHX9 ROCK2 KIF13B NR2F2 XIRP2 MACF1 TOP2B

2.54e-051762177749b47eac5436fa34e0d243ffbc6f1897f4e431e
ToppCell3'-Parenchyma_lung-Endothelial-Lymphatic_EC-endothelial_cell_of_lymphatic_vessel-Lymphatic_EC_differentiating-Lymphatic_EC_differentiating_L.2.5.1.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

PIEZO1 SPTBN1 DST UTRN NR2F2 MACF1 TNXB

2.74e-051782177ad3de3e03a401dac64431a541899445262246347
ToppCell343B-Lymphocytic-NK_cells-NK_cell_A2|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

BTBD6 GALNT2 FANCA CCDC102A ARFGEF2 ARFGEF1 DNAH1

2.94e-05180217762511d76d24b836839c3dcc2bf30485ffe9401e2
ToppCell3'-GW_trimst-2-LargeIntestine-Mesenchymal-myocytic-SMC_(PART1/CAPN3+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ILK ITGA1 DST SPARCL1 KRT13 MACF1 PDE5A

3.04e-051812177beb2771820956be8b190c0088ae3c4efdb53c897
ToppCellCOVID-19-Epithelial_cells-Airway_club|COVID-19 / group, cell type (main and fine annotations)

ACACA DUOX1 PLEKHA7 DNAH5 ARFGEF3 FARP1 RIMS1

3.50e-051852177cfe6fd73d817e173fe803bc1683c291d9bcb8608
ToppCellCOVID-19-Epithelial_cells-Airway_ciliated|COVID-19 / group, cell type (main and fine annotations)

CFAP206 DNAH5 NPHP1 DNAH3 DNAH2 EFHC2 TTC29

3.50e-05185217718a40f0a338aa398d81384b5159fb80ce8a2020c
ToppCellNS-moderate-d_16-33-Epithelial-Ciliated|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

CFAP206 DNAH5 DNAH3 DNAH2 C2orf81 EFHC2 TTC29

3.50e-0518521775e689c2fb36ce3ac2adc8d15f67107f21cf68868
ToppCellwk_15-18-Epithelial-Distal_epithelial_progenitor-epi-tip_intermediate|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

NOL6 C20orf204 PLEKHA7 PLS1 ZFP30 MAMDC4 GREB1

3.50e-051852177636505a3d96f75d951ab42bcf8af6ae07abc732d
ToppCelldroplet-Marrow-nan-3m-Myeloid|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SPTBN1 ITGA1 DHX9 NIPBL ROCK2 MACF1 TOP2B

3.50e-0518521777adfa929930cfa795cbfbd9f1a0b439e08aa765d
ToppCellfacs-Limb_Muscle-ForelimbandHindlimb|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ERFE UTRN ROCK2 KRT13 NAA15 KRT16 SPAG9

3.50e-051852177eb7d3c1363d5fedc611f9c1a91ea823de251355e
ToppCell356C-Endothelial_cells-Endothelial-C_(Capillary_Aerocyte_)-|356C / Donor, Lineage, Cell class and subclass (all cells)

NES SPTBN1 ITGA1 SPARCL1 PLS3 LOXHD1 ARAP3

3.62e-051862177f0b78c7ee20279970ea8961bf59acb5262f2dce5
ToppCell356C-Endothelial_cells-Endothelial-C_(Capillary_Aerocyte_)|356C / Donor, Lineage, Cell class and subclass (all cells)

NES SPTBN1 ITGA1 SPARCL1 PLS3 LOXHD1 ARAP3

3.62e-0518621772b3c814a7dee8286ea113c63dc3de5daf0257d37
ToppCell10x5'-GI_small-bowel-Lymphocytic_T_CD4-T_CD4/CD8|GI_small-bowel / Manually curated celltypes from each tissue

ITGA1 ANKRD12 UTRN NIPBL ARFGEF1 MACF1 PCNX1

3.88e-051882177ab9b725d6e0cdab8e9ddda6dee09e14730e9a578
ToppCellfacs-Brain_Non-Myeloid-Striatum_-18m-Neuronal|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PLVAP SPTB PHYHIP ANKRD12 SLC1A6 RIMS1 RIMS2

4.01e-0518921773d838da870623a6a278ddc8e6cedca85d9877e50
ToppCelldroplet-Liver-Hepatocytes-24m-Endothelial-endothelial_cell_of_hepatic_sinusoid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NES PLVAP KLHL35 SH3RF1 ZFP30 NR2F2 ARAP3

4.01e-051892177ce5b3d53c9a5457a5a02b221dee18334b5eaf8b7
ToppCellfacs-Heart-LV-3m-Endothelial-endothelial_cell_of_coronary_artery|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SPTBN1 ITGA1 SPARCL1 MMP15 UTRN PLS3 ARAP3

4.01e-051892177393ec5954a12d6cf67bb435dcc34ff0b14c81e9f
ToppCellfacs-Heart-LV-3m-Endothelial-coronary_vascular_endothelial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SPTBN1 ITGA1 SPARCL1 MMP15 UTRN PLS3 ARAP3

4.01e-051892177bec57459ad4bab15b2532b57722549fec2e771fb
ToppCelldroplet-Kidney-nan-21m-Epithelial-Stroma____kidney_mesangial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NES KLHL30 SPARCL1 KLHDC8B TTC29 DAAM2 PDE5A

4.14e-051902177e04f47705851563515b6a66a2634cf7a574f7bda
ToppCellCOVID-19-Heart-EC_+_Pericyte|Heart / Disease (COVID-19 only), tissue and cell type

ITGA1 SPARCL1 UTRN ROCK2 NR2F2 DAAM2 RIMS1

4.14e-051902177a21653bfb7bafbc273f94fa7c13bfb48cf8fd562
ToppCellLV-08._Macrophage|World / Chamber and Cluster_Paper

PDE4B TRPM2 DOCK2 LCP1 CSF2RA TLR2 DAAM2

4.29e-051912177e7a0bc46ba9ba772636a583f3387748418e18832
ToppCellEntopeduncular-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)|Entopeduncular / BrainAtlas - Mouse McCarroll V32

CACNA2D2 PHYHIP SRPK2 PCNX2 ANKRD12 ARFGEF3 TMEM179

4.29e-0519121775d24022cec293bc8d9e978ae99a109e660bb8f83
ToppCellChildren_(3_yrs)-Epithelial|Children_(3_yrs) / Lineage, Cell type, age group and donor

ACACA CACNA2D2 DUOX1 SH3RF1 ARFGEF3 FARP1 SNX25

4.29e-051912177e432c6e1ae82dddf84314ce73d2b7a991630d905
ToppCellEntopeduncular-Neuronal-Inhibitory|Entopeduncular / BrainAtlas - Mouse McCarroll V32

CACNA2D2 PHYHIP SRPK2 PCNX2 ANKRD12 ARFGEF3 TMEM179

4.29e-05191217773dae4cdea86aec62393ad7303dc7375a6b3fc86
ToppCellEpithelial|World / Lineage, Cell type, age group and donor

ACACA CACNA2D2 DUOX1 SH3RF1 ARFGEF3 FARP1 SNX25

4.43e-051922177499e8893afea5e6d3371e0bd018f7e86a524d669
ToppCellLV-08._Macrophage|LV / Chamber and Cluster_Paper

PDE4B TRPM2 DOCK2 LCP1 CSF2RA TLR2 DAAM2

4.43e-0519221777be12d580aaf2f2f1562203fcad3a44639b8c5a6
ToppCellrenal_cortex_nuclei|World / Celltypes from Cells and Nuclei per compartment and clinical group

SRPK2 RABGAP1L PLEKHA7 DIP2B SH3RF1 FARP1 MACF1

4.43e-051922177e8cc4d08fcfceeab75a02558817e4ccd7dbafe3a
ToppCellRV-08._Macrophage|RV / Chamber and Cluster_Paper

PDE4B TRPM2 DOCK2 LCP1 CSF2RA TLR2 DAAM2

4.58e-05193217712bf98a280f87e4d8f0c6887dfc855da72e47ac1
ToppCellPCW_05-06-Mesenchymal-Mesenchymal_myocytic-mes_immature_ASM1_(8)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

ITGA1 PKM MICAL3 PLS3 FARP1 RIMS1 GREB1

4.58e-051932177e2b455387d1de7812305200a2041a0f4759a6f54
ToppCelldroplet-Fat-Mat-18m-Endothelial|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PLVAP SPTBN1 DST SPARCL1 UTRN PLS3 ARAP3

4.58e-05193217754024a373e42e1c0bcc327dc084564b83b63a9d4
ToppCelldroplet-Fat-Mat-18m-Endothelial-endothelial_cell|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PLVAP SPTBN1 DST SPARCL1 UTRN PLS3 ARAP3

4.58e-05193217781d908594d2983ba7e7c1ec25afdde4315d9690e
ToppCellNS-critical-d_07-13-Epithelial-Ciliated|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

CFAP206 DNAH5 NPHP1 DNAH3 DNAH2 EFHC2 TTC29

4.73e-0519421771ae8a10e508e672e6677f0e3c986ac30d05adeb3
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

ACACA CACNA2D2 DUOX1 SH3RF1 SYNE1 ARFGEF3 SNX25

4.73e-05194217797534c8bba895a7913665e03ae4e5c4a6ad71daf
ToppCellPND03-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP1-CAP1_mature|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PDE4B PLVAP SPTBN1 ITGA1 ARMCX4 SPARCL1 ARAP3

4.73e-0519421777f24023df47935286f185dd428d48797daf26f49
ToppCelldroplet-Limb_Muscle-MUSCLE|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ITGA1 ANKRD12 UTRN NIPBL ROCK2 SPAG9 MACF1

4.73e-051942177e3d63874111d1e8da3977329426e4dcf68d6de87
ToppCellPND10-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP1|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PDE4B PLVAP SPTBN1 ITGA1 ARMCX4 SPARCL1 ARAP3

4.73e-0519421771b382508453c5b08fb617f626b230adf3b6cff99
ToppCellLA-08._Macrophage|World / Chamber and Cluster_Paper

PDE4B TRPM2 DOCK2 LCP1 CSF2RA TLR2 DAAM2

4.73e-051942177c1805572bcc11b1cd29083329d7b5911489fb758
ToppCell343B-Lymphocytic-NK_cells-NK_cell_A2|343B / Donor, Lineage, Cell class and subclass (all cells)

GALNT2 FANCA CCDC102A ARFGEF2 ARFGEF1 DNAH1

4.84e-0513321768ff1cf0ea1fc33fe8384c0e65c1ee1853b25a2ae
ToppCellLA-08._Macrophage|LA / Chamber and Cluster_Paper

PDE4B TRPM2 DOCK2 LCP1 CSF2RA TLR2 DAAM2

4.89e-0519521775e1d5bdb8874091f5a2b1d0a8cc9008165718a97
ToppCellmoderate-Epithelial-Ciliated|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

DNAH5 NPHP1 DNAH3 SYNE1 DNAH2 EFHC2 TTC29

4.89e-0519521773486eae5fdb062a75a907b896c9d7b396d2aa195
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Immune|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PDE4B TRPM2 BLK DOCK2 LCP1 CSF2RA TLR2

4.89e-0519521772d485373bfd9bb4bb9236bf0b31d03e132c8018f
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Immune|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PDE4B TRPM2 BLK DOCK2 LCP1 CSF2RA TLR2

4.89e-0519521777b6c69df943842b566a596e30bb50dbe80dccc83
ToppCellControl_saline-Epithelial_airway-airway_epithelial-Ciliated|Control_saline / Treatment groups by lineage, cell group, cell type

CFAP206 DNAH5 DNAH3 DNAH2 C2orf81 DNAH1 TTC29

4.89e-05195217760067b5359174f0d1a8b5748bfc0690762e9e740
ToppCellPND10-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP1-CAP1_mature|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PDE4B PLVAP SPTBN1 ITGA1 ARMCX4 SPARCL1 ARAP3

4.89e-051952177cd011433b3b9bfb1adb13eca2f3f2a5db024cd94
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Lymphoid-CD4/CD8-CD8_EM-F|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

ZNF461 CFAP206 NPR2 RFX4 ZNF420 TAF5L SLX4

5.05e-0519621777e98380d815fbf6254289ace2af37aac6fef51e8
ToppCell368C-Fibroblasts-Fibroblast-G|368C / Donor, Lineage, Cell class and subclass (all cells)

SPTBN1 DST SPARCL1 PLS3 MACF1 PDE5A TNXB

5.21e-051972177156155c2f0c1a2461e45803da578af18ee221660
ToppCellnormal_Lung-Fibroblasts-COL13A1+_matrix_FBs|normal_Lung / Location, Cell class and cell subclass

ARSI DST SPARCL1 NR2F2 MACF1 PDE5A TNXB

5.21e-0519721776c57ab2efb8363828e24211c4d45e58bb73a9a4d
ToppCell368C-Fibroblasts-Fibroblast-G-|368C / Donor, Lineage, Cell class and subclass (all cells)

SPTBN1 DST SPARCL1 PLS3 MACF1 PDE5A TNXB

5.21e-051972177d5d9263451f6c10cb3b9c17740183ca334e24851
ToppCellControl_saline-Epithelial_airway|Control_saline / Treatment groups by lineage, cell group, cell type

CFAP206 DNAH5 DNAH3 KRT16 DNAH2 DNAH1 TTC29

5.38e-051982177e6863238e022ecfb6a8e3f4b7661b376e92c5d8f
ToppCellControl-Control-Lymphocyte-T/NK-NK_activated|Control / Disease, condition lineage and cell class

NUGGC EDC4 UTRN SYNE1 OAS3 LCP1 MACF1

5.38e-05198217776d5fe4e5bbe6c73a6ca409b80b5c3924e07cab7
ToppCellControl_saline-Epithelial_airway-airway_epithelial|Control_saline / Treatment groups by lineage, cell group, cell type

CFAP206 DNAH5 DNAH3 KRT16 DNAH2 DNAH1 TTC29

5.38e-051982177e7aa42e5fbd42c68f50cda4a8f3aa464c862c007
ToppCell(11)_FOXN4+-(2)_GFP_FOXI1|(11)_FOXN4+ / shred by cell type by condition

SRPK2 ANKRD12 UTRN NIPBL NAA15 ROCK1 TGS1

5.38e-05198217776d40b8c2f8399725b3a62ee2ae0896559cf91eb
ToppCellASK454-Epithelial-Type_2|ASK454 / Donor, Lineage and Cell class of Lung cells from Dropseq

ZNF133 ZSWIM9 CCDC102A ATP8B3 BBS5 DAAM2

5.48e-051362176ff9a5e111993fdb3ac64c5ef269e3460ff994517
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell_|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

NES PLVAP SPTBN1 ITGA1 SPARCL1 ARAP3 TNXB

5.55e-051992177da5a88749d859d535daa030d0974485906cc0ba7
ToppCell(04)_Interm._basal>secr.-(2)_GFP_FOXI1|(04)_Interm._basal>secr. / shred by cell type by condition

SRPK2 ANKRD12 NIPBL ROCK2 NAA15 WWP1 ROCK1

5.55e-05199217753ca3861f9e00dab3f3fbefb0837857ee39ab084
ToppCellBronchial-10x5prime-Stromal-Myofibroblastic|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

SPTB ITGA1 ECEL1 SPARCL1 NR2F2 DAAM2 PDE5A

5.55e-051992177ad75e5e26c37a97331164d7f77235ebd9a933a44
ToppCellLPS_IL1RA_TNF-Mesenchymal_fibroblastic-Fibroblasts-MatrixFB|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

ARSI DST SPARCL1 SYNE1 NR2F2 MACF1 TNXB

5.55e-05199217730d3e8c0681ec11f86dd38c5f48d21187a1b4f90
ToppCellBronchial-10x5prime-Endothelial-Endothelia_vascular-VE_alveolar_capillary_Car4_aerocyte|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

NES SPTBN1 ITGA1 SPARCL1 PLS3 ARAP3 TNXB

5.55e-0519921777ed541309808f15d65a9c4b26be2050e077539e6
ToppCell5'-GW_trimst-2-LargeIntestine-Hematopoietic|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TRPM2 UTRN DOCK2 WWP1 LCP1 CSF2RA TLR2

5.55e-0519921775ceeed92f831d068ff4bb3994f420002338330e7
ToppCellPSB-critical-LOC-Epithelial|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

GALNT3 SPTBN1 DNAH5 PLS1 NR2F2 ARFGEF3 FARP1

5.55e-05199217758dcb0eedafa8629585dc99e53147e2287f49689
ToppCellSubstantia_nigra-Macroglia-POLYDENDROCYTE-P2|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

GALNT2 FANCA TRPM8 SAPCD1 CKAP2

5.65e-058421751f8b19b159f83655f66cb99f8d10d9a87c08f78f
ToppCellSubstantia_nigra-Macroglia-POLYDENDROCYTE-P2-Tnr|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

GALNT2 FANCA TRPM8 SAPCD1 CKAP2

5.65e-05842175503490e9408d9638bcd089ef8ec0521924df9a5d
ToppCellSubstantia_nigra-Macroglia-POLYDENDROCYTE-P2-Tnr-Polydendrocyte.Tnr.Bmp4_(Bmp4)|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

GALNT2 FANCA TRPM8 SAPCD1 CKAP2

5.65e-05842175c37e1170d39ad015f724e373a547ea5b6ba45a84
ToppCellSubstantia_nigra-Macroglia-POLYDENDROCYTE-P2-Tnr-Polydendrocyte.Tnr.Bmp4_(Bmp4)-|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

GALNT2 FANCA TRPM8 SAPCD1 CKAP2

5.65e-058421757e4a76b65b0d34d9950f8b02590ff5a4b4534a27
ToppCellLPS_anti-TNF-Mesenchymal_fibroblastic-Fibroblasts-MatrixFB|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

SPTBN1 ARSI DST SPARCL1 SYNE1 MACF1 TNXB

5.73e-0520021779b0916d8d07ac2bf1739f7be5296bf77ffee6094
ToppCellLPS_only-Endothelial-Endothelial-Activated_Alv_Cap|LPS_only / Treatment groups by lineage, cell group, cell type

PDE4B SPTBN1 ITGA1 SPARCL1 ROCK2 OAS3 MACF1

5.73e-052002177edb64556b3fefe3144f73b6efe23b9ffd34091d2
ToppCellParenchyma_Control_(B.)-Stromal-TX-Fibroblasts-1|Parenchyma_Control_(B.) / Sample group, Lineage and Cell type

ITGA1 DST SPARCL1 NR2F2 MACF1 PDE5A TNXB

5.73e-052002177aa1a35dcca3b799241eef4237f6eb94660e019f0
Drugplakin

SPTB SPTBN1 DST UTRN PLS3 KRT16 DSG1 SYNE1 MACF1

7.23e-08822129CID000018752
DrugN-methylpyrrole

ACACA DST PKM IMMT

2.29e-06112124CID000007304
Drug(R) -Naproxen sodium salt [26159-34-2]; Up 200; 15.8uM; MCF7; HT_HG-U133A

SPTBN1 MAPK8IP3 FANCA ARHGEF9 KCNN1 FGD1 POLM GALNT12 SLC1A7 WDR19 PCNX1

2.80e-06199212116794_UP
DrugAC1L9LMC

ACACA SPTB ARSI DST UTRN VPS18 SYNE1

1.25e-05832127CID000448113
DrugHomocysteine

ACADM SPTBN1 RAB9A PLEKHA7 BRWD1 ROCK2 ARFGEF1 PDE5A SLX4 TOP2B

1.54e-0519521210ctd:D006710
DrugQuinic acid [86-68-0]; Down 200; 19.6uM; HL60; HT_HG-U133A

NOL6 EDC4 ARHGEF9 PLS1 TBC1D30 POMT1 SLC1A7 NR2F2 ARAP3 MACF1

1.61e-05196212102978_DN
DrugColistin sulfate [1264-72-8]; Up 200; 3uM; MCF7; HT_HG-U133A

PHYHIP KCNN1 UTRN ATG5 OAS3 GRIK5 SLC1A7 TMEM209 DAAM2 RIMS2

1.68e-05197212104796_UP
DrugIdazoxan hydrochloride [79944-56-2]; Up 200; 16.6uM; PC3; HT_HG-U133A

PDE4B ACSM3 PAX8 RABGAP1L ATAD2B NPR2 ZFP30 TEX14 RLN2 BRF1

1.68e-05197212106747_UP
DrugEtoposide [33419-42-0]; Down 200; 6.8uM; PC3; HT_HG-U133A

CACNA2D2 MICAL3 NIPBL BRWD1 TBC1D30 SYNE1 ZFP30 VPS50 RIMS2 TGS1

1.76e-05198212106681_DN
Drugcnicin

PIK3C3 PLS1 PLS3 KIF13B ADAP1 LCP1 ARAP3

2.46e-05922127CID000091176
DiseaseColorectal Carcinoma

ACACA APC2 PAX8 ATG5 DNAH3 VPS18 CAD SYNE1 ARFGEF1 GALNT12 SLC1A7 GMCL2 ARAP3 BRF1 TLR2 MUTYH

4.47e-0570220916C0009402
Disease4-hydroxyphenylacetylglutamine measurement

ACSM3 DNAH3

1.49e-0432092EFO_0800688
Diseasespinocerebellar ataxia type 5 (implicated_via_orthology)

SPTB SPTBN1

2.97e-0442092DOID:0050882 (implicated_via_orthology)
Diseaseepisodic ataxia type 6 (implicated_via_orthology)

SLC1A6 SLC1A7

7.35e-0462092DOID:0050994 (implicated_via_orthology)
Diseasemyeloperoxidase measurement

GALNT2 TAF5L TNXB

8.08e-04262093EFO_0005243
DiseaseUrogenital Abnormalities

APC2 FGD1

1.02e-0372092C0042063
DiseaseNephronophthisis, familial juvenile

NPHP1 WDR19

1.02e-0372092C1855681
DiseaseSenior-Loken syndrome (is_implicated_in)

NPHP1 WDR19

1.02e-0372092DOID:0050576 (is_implicated_in)
DiseaseRenal dysplasia and retinal aplasia

NPHP1 WDR19

1.02e-0372092cv:C0403553
Diseaserespiratory failure, COVID-19

DST TTC7B OAS3

1.12e-03292093EFO_0009686, MONDO_0100096
DiseaseCongestive heart failure

ACACA GCG ROCK2 TLR2 PCK1

1.14e-031102095C0018802
DiseaseHeart failure

ACACA GCG ROCK2 TLR2 PCK1

1.14e-031102095C0018801
DiseaseLeft-Sided Heart Failure

ACACA GCG ROCK2 TLR2 PCK1

1.14e-031102095C0023212
DiseaseHeart Failure, Right-Sided

ACACA GCG ROCK2 TLR2 PCK1

1.14e-031102095C0235527
DiseaseHeart Decompensation

ACACA GCG ROCK2 TLR2 PCK1

1.14e-031102095C1961112
DiseaseMyocardial Failure

ACACA GCG ROCK2 TLR2 PCK1

1.14e-031102095C1959583
Diseasecolorectal cancer (implicated_via_orthology)

APC2 BLK BRF1

1.24e-03302093DOID:9256 (implicated_via_orthology)
Diseaseanxiety disorder

PDE4B TTC7B MGAM2

1.24e-03302093EFO_0006788
DiseaseHereditary spherocytosis

SPTB CAD

1.36e-0382092C0037889
DiseaseX-17676 measurement

ACSM3 DNAH3

1.36e-0382092EFO_0800785
Diseaseage at initiation of corrective lens use

BRWD1 RFX4

1.36e-0382092EFO_0021781
Diseasetotal blood protein measurement

TRAF3 C20orf204 ITGA1 BLK MICAL3 ATG5 DNAH3 DNAH1 MACF1 ROCK1

1.45e-0344920910EFO_0004536
DiseaseHuntington's disease (implicated_via_orthology)

PLS1 PLS3 LCP1

1.49e-03322093DOID:12858 (implicated_via_orthology)
DiseaseManic Disorder

PDE4B TRPM2 SRPK2 RIMS1

1.64e-03712094C0024713
DiseaseNephronophthisis

IFT172 NPHP1

1.74e-0392092cv:C0687120
Diseasenon-high density lipoprotein cholesterol measurement

PLVAP GALNT2 ITGA1 NPFFR2 RABGAP1L NPC1L1 BRWD1 KIF13B DIP2B UGT1A7 ARFGEF2 GRIK5 LCP1

1.82e-0371320913EFO_0005689
Diseasepostburn hypertrophic scarring severity measurement

GALNT2 DSG1

2.16e-03102092EFO_0007747
DiseaseAbnormality of nervous system morphology

APC2 MAPK8IP3

2.16e-03102092C4022810
Diseaserheumatoid arthritis, systemic lupus erythematosus

BLK ATG5

2.16e-03102092EFO_0000685, MONDO_0007915
DiseaseBipolar Disorder

PDE4B TRPM2 SRPK2 PIK3C3 SYNE1 GRIK5 RFX4 SLC1A6 TLR2 RIMS1

2.25e-0347720910C0005586
Diseasevitamin D deficiency

NPFFR2 UGT1A7 PCNX1

2.28e-03372093EFO_0003762
DiseaseManic

PDE4B TRPM2 SRPK2 RIMS1

2.32e-03782094C0338831
Diseasesmoking cessation

PDE4B SRPK2 RABGAP1L ATAD2B KLHDC8B TCTA NR2F2 TTC29

2.32e-033252098EFO_0004319
DiseaseDepression, Bipolar

PDE4B TRPM2 SRPK2 RIMS1

2.43e-03792094C0005587
Diseasehepatocyte growth factor-like protein measurement

CACNA2D2 KLHDC8B DNAH1

2.46e-03382093EFO_0008154
Diseasebirth weight, parental genotype effect measurement

AMZ1 CCDC201 ARFGEF2 GPRC6A ARAP3 PDE5A

2.54e-031922096EFO_0004344, EFO_0005939
DiseaseJeune thoracic dystrophy

IFT172 WDR19

2.63e-03112092C0265275
Diseaselignoceroylcarnitine (C24) measurement

WWP1 SLC1A7

2.63e-03112092EFO_0800541
Diseasebipolar disorder

SRPK2 DOCK2 ATP8B3 TMEM217 SYNE1 GRIK5 XPNPEP1 BTN2A1 TMEM179 PDE5A RIMS1

2.88e-0357720911MONDO_0004985
DiseaseRenal dysplasia and retinal aplasia (disorder)

NPHP1 WDR19

3.14e-03122092C0403553
Diseaselevel of Diacylglycerol (18:1_18:2) in blood serum

GALNT2 LCP1

3.14e-03122092OBA_2045171
DiseaseS-6-hydroxywarfarin to S-warfarin ratio measurement

NPFFR2 SPAG9 FARP1 PCK1

3.59e-03882094EFO_0803332
Disease3-carboxy-4-methyl-5-propyl-2-furanpropanoate CMPF measurement

KCNN1 GRIK5

3.70e-03132092EFO_0021053
DiseaseBardet-Biedl Syndrome

IFT172 NPHP1

3.70e-03132092C0752166
DiseaseNephronophthisis

NPHP1 WDR19

3.70e-03132092C0687120
DiseaseUterine leiomyoma

SYNE1 DNAH2 PLEKHM3 GREB1

4.04e-03912094HP_0000131
DiseaseBardet-Biedl syndrome (is_implicated_in)

NPHP1 BBS5

4.30e-03142092DOID:1935 (is_implicated_in)
DiseaseFanconi anemia

FANCA SLX4

4.30e-03142092cv:C0015625
Diseasecongenital hypothyroidism (implicated_via_orthology)

DUOX1 PAX8

4.30e-03142092DOID:0050328 (implicated_via_orthology)
DiseaseDegenerative polyarthritis

IMMT PLS3 OPA1 PPP2R1A

4.37e-03932094C0029408
DiseaseOsteoarthrosis Deformans

IMMT PLS3 OPA1 PPP2R1A

4.37e-03932094C0086743
Diseasetestosterone measurement

PDE4B ERCC6L CYP27B1 TRPM2 RYK PNMA6F ARHGEF9 FGD1 UTRN BRWD1 ATP8B3 DIP2B UGT1A7 DNAH2 MACF1 DAAM2 PLEKHM3 GREB1

4.37e-03127520918EFO_0004908
Diseasehemolysis

PIEZO1 PAX8 ATAD2B

4.52e-03472093EFO_0009473
DiseaseIntellectual Disability

APC2 PEX11B MAPK8IP3 NAA15 KDM5A SYNE1 PPP2R1A BRF1 MACF1

4.80e-034472099C3714756
Diseaseurate measurement, bone density

ZNF133 FANCA RABGAP1L UTRN SYNE1 UGT1A7 LCP1 DNAH1 GLIPR1L2 PRKDC TNXB

4.86e-0361920911EFO_0003923, EFO_0004531
DiseaseAnilide use measurement

RABGAP1L TRPM8

4.93e-03152092EFO_0009938
Diseasetriacylglycerol 52:3 measurement

GALNT2 LCP1

4.93e-03152092EFO_0010415
Diseaseamenorrhea, response to antineoplastic agent

VPS50 RIMS1

4.93e-03152092EFO_0010269, GO_0097327
Diseasevitamin D measurement, COVID-19

NPFFR2 UGT1A7 OAS3

5.08e-03492093EFO_0004631, MONDO_0100096
Diseasecholesteryl esters to total lipids in IDL percentage

GALNT2 LCP1 MACF1

5.37e-03502093EFO_0022247
Diseasediacylglycerol 44:7 measurement

IFT172 LCP1

5.61e-03162092EFO_0020069
Diseasepulmonary function measurement, FEV/FEC ratio

ITGA1 MMP15 DAAM2

6.33e-03532093EFO_0003892, EFO_0004713
Diseaseocular hypertension (biomarker_via_orthology)

ACSM3 OPA1

6.33e-03172092DOID:9282 (biomarker_via_orthology)
Diseasemuscular dystrophy (is_implicated_in)

SYNE1 POMT1

6.33e-03172092DOID:9884 (is_implicated_in)
DiseaseQRS-T angle

SPTBN1 MMP15 FARP1 PCNX1

6.92e-031062094EFO_0020097

Protein segments in the cluster

PeptideGeneStartEntry
AAEDKSWRVRYMVAD

PPP2R1A

251

P30153
MDVQAERAWRVVFEA

MAMDC4

931

Q6UXC1
MSVLDALWEDRDVRF

BBS5

1

Q8N3I7
VREGRVQWISMAFES

DISP3

1111

Q9P2K9
VFVFRTESEAQRDMW

ARAP3

356

Q8WWN8
DRAVDALDRWEMFTG

AMZ1

431

Q400G9
NWTEALENVFMENRR

CACNA2D2

226

Q9NY47
YRAQMEAEWREALRA

C8orf33

166

Q9H7E9
IQESVWDEAMRRLQE

ALDH16A1

311

Q8IZ83
DVENWARSIELDMRT

BLOC1S1

121

P78537
NLERMASVRQAVWLF

ARSI

451

Q5FYB1
WEVIDAQAEMALRSE

BTBD6

261

Q96KE9
SDDMNVAPEDRVWVR

ARFGEF1

1366

Q9Y6D6
ERAAWTVAVRTEAVM

C20orf204

121

A0A1B0GTL2
LFRMYVDENRRDSWE

ARFGEF2

1666

Q9Y6D5
ESFQMNRIDTGWLDR

ACACA

601

Q13085
DGQIQAMLRRWFVEV

ACACA

2241

Q13085
RLDAWEEAQVEFMAS

ADAP1

61

O75689
DILENDSINLDWMFR

NPR2

606

P20594
RAEAAAAAWEKMEAR

ANKRD35

526

Q8N283
MDEAWQELGQSRRDF

ATP8B3

846

O60423
ELARMSYQRAAWEVD

ACADM

331

P11310
SVRDRFNARQFMSWL

ANKRD12

1976

Q6UB98
MTDDKDVLRDVWFGR

ATG5

1

Q9H1Y0
MRFDRARSNVIFWES

CCDC42

226

Q96M95
IAAERWIKFRFQTMD

ARMCX4

1106

Q5H9R4
WLRAFREERKMVQED

ARHGEF9

416

O43307
MEDRVNVADFRKLEW

CFAP206

386

Q8IYR0
AEEAVSWQERRMAAA

POLM

76

Q9NP87
FWTTMAEEDEQRLFT

CKAP2

406

Q8WWK9
ARRERFIMNEKWDTN

NPFFR2

96

Q9Y5X5
TMFAWEIRDRLLAEG

PAX8

101

Q06710
RTEEAAWAAMALTFL

TP53I13

306

Q8NBR0
GENSRVLEWMFNRID

PCK1

531

P35558
VTMQIWDTAGQERFR

RAB9A

56

P51151
DITFQMLEDWRNVDL

RFX4

341

Q33E94
LNQFSRAVADSWMEE

RLN2

16

P04090
AARMLFSAVEWARNI

NR2F2

216

P24468
EDRAEVWDLDMLRSS

EDC4

261

Q6P2E9
LLEDDAQRNFSVWMR

PARP2

136

Q9UGN5
QEAVRWTEMIRASRE

SPAG9

526

O60271
VEMEAYDTVRDTWTR

KLHL30

531

Q0D2K2
EKRARFSELWRAIMD

ANKAR

166

Q7Z5J8
DWDQMFAFAQRHVER

CYP27B1

256

O15528
QEWELREQELMRAAV

DUOX1

741

Q9NRD9
RLQWENVSAMIEEVF

OARD1

126

Q9Y530
TVWNEIDDMQVFRIL

DAAM2

621

Q86T65
EALRRSDLVEEFWMK

MICAL3

1316

Q7RTP6
QEAVRWTEMIRASRE

MAPK8IP3

546

Q9UPT6
GWESEAAMERARQQV

NFS1

96

Q9Y697
MEAARPFAREWRAQS

GLIPR1L2

1

Q4G1C9
MEDLEQIFLRSWRES

GREB1

456

Q4ZG55
TDDRTTWDIDRQFML

MGAM2

1596

Q2M2H8
RFQDALESLLSWMVD

DST

5396

Q03001
LWELIRTMVDRAEAE

ASL

136

P04424
SGEVERLRMWTDTEF

ATAD2B

211

Q9ULI0
VEANRRDVEEWFNMQ

KRT32

276

Q14532
MEAVRRAFRVWEQAT

MMP15

161

P51511
QLFMVDNGADDWRIA

KCNN1

166

Q92952
VFARNTRRAAEVWMD

GALNT2

376

Q10471
YEAMAERNRRDAEEW

KRT13

281

P13646
WFLDRIDITDMNNEI

LOXHD1

896

Q8IVV2
WDDSVSMFGDRRELI

EFHC2

236

Q5JST6
RISSIRDEWIFADME

PCNX1

1831

Q96RV3
DFRITARDEWVFADM

PCNX2

1666

A6NKB5
LEGESKEERTFRNWM

PLS1

391

Q14651
EGETREERTFRNWMN

LCP1

391

P13796
EERTFRNWMNSLGVN

LCP1

396

P13796
ETREERTFRNWMNSL

PLS3

396

P13797
RDMEAWAASLARSQQ

PNMA6F

421

A0A0J9YX94
MWLNARRDLDRINAS

PLVAP

101

Q9BX97
RQWTDRIMEEFFQQG

PDE4B

576

Q07343
VRKATREMVNAWFAE

PDE5A

46

O76074
VRAQAWSQDMAEDRR

CUL7

991

Q14999
VDPRDAWMLFVRQSD

ERFE

76

Q4G0M1
LQEEDTRMQQADRDW

NIPBL

2241

Q6KC79
AIREAVVWEAASMSQ

NOL6

596

Q9H6R4
EEDSFQWMSRVLQAI

DIP2B

871

Q9P265
GEESFQMWELNRRLE

NES

6

P48681
MAEKNRRDAETWFLS

KRT16

296

P08779
ESRRVAQDWLKEARM

IMMT

716

Q16891
AWAEDVDLRVNFAMN

PKM

481

P14618
NQFDWALMRLDLSVR

LRPPRC

81

P42704
LDSRRAQDFVQWLMN

GCG

66

P01275
LRAETRQRAQEWMEA

PLEKHM3

436

Q6ZWE6
WDSVTAFLNDLLERM

ITGA1

186

P56199
RVIDLDEEFSANWMA

DSG1

291

Q02413
EELDWMDAETRAAAR

ECEL1

486

O95672
ERAMSWQDRARQALA

KDM5A

1251

P29375
EAARWMDEAQALDTA

NAA15

426

Q9BXJ9
MVFFWEDIKARAEER

MACF1

5981

Q9UPN3
AELARMGFDLQNVWR

MTMR4

161

Q9NYA4
SWSMTFEERENRRLQ

RABGAP1L

6

B7ZAP0
RDWVLTVSMDQRLEQ

IFT172

1646

Q9UG01
RDFRERMLEITVWDQ

RIMS1

821

Q86UR5
AIERNFVMRNDFLWD

GPRC6A

391

Q5T6X5
FRERMLEITLWDQAR

RIMS2

886

Q9UQ26
LWEEAFLEEMRAFQR

NPC1L1

591

Q9UHC9
FSELQWRMLALRSDD

POMT1

546

Q9Y6A1
AARWAEVMARFAARL

PPCS

16

Q9HAB8
EVAWETLQEEFSRFM

OPA1

671

O60313
DRFQMLHNRAEDWEV

CEP135

881

Q66GS9
NRRLAEVWMDEFKNF

GALNT1

366

Q10472
SSNVEDWLREVERSM

DNAH1

1391

Q9P2D7
TDDWDRRCIMNILED

DNAH1

3886

Q9P2D7
VFWLLSMLATRDQED

APC2

276

O95996
MWFTENQREDRRKDV

CEFIP

746

Q711Q0
RLMLLESWRSFEEEF

CRNKL1

751

Q9BZJ0
ENEFASMWIERTSFV

DOCK2

1456

Q92608
LIIAVDWALDRFRTM

SLC1A7

446

O00341
EWMDGVLANAFREQA

DNAH3

1766

Q8TD57
QETTEEFNREMFWRR

CCNDBP1

41

O95273
EFNREMFWRRLNEAA

CCNDBP1

46

O95273
MFWRRLNEAAVTVSR

CCNDBP1

51

O95273
AESEYTFERWMEVIR

FARP1

1011

Q9Y4F1
WEDQAESLRTAMINR

CACNA2D4

596

Q7Z3S7
VIARNQVRLAEVWMD

GALNT3

431

Q14435
ASDAVQMQREWSFAR

FANCA

336

O15360
LLEDWVARLMAQAFE

FANCA

406

O15360
NFVARVESLEMERWF

BLK

111

P51451
EWSRDSMEINEADFR

ARFGEF3

466

Q5TH69
SMEINEADFRWQRRV

ARFGEF3

471

Q5TH69
EMERLQAENAAEWGR

CCDC102A

346

Q96A19
EDTNRRSADMWSFAV

ILK

366

Q13418
ALANSVRAAEVWMDE

GALNT12

376

Q8IXK2
VDWFLDRLRTMTNVL

SLC1A6

496

P48664
RFEQLEWRSILLDMA

BRWD1

396

Q9NSI6
EKNAEDMEVRWFRSQ

BTN2A1

56

Q7KYR7
LAAGDAVWVRMFQRD

C1QTNF8

211

P60827
AVWVRMFQRDRDNAI

C1QTNF8

216

P60827
AEARSRALFLMEAIW

DHDH

111

Q9UQ10
AVEAFLMDEGRWERR

KLHDC8B

96

Q8IXV7
EAMLQITEWRFLARD

C2orf81

91

A6NN90
DFVWMRARLQQEVEE

HAUS4

156

Q9H6D7
VAVMEFIWSTRRSAE

GRIK5

821

Q16478
SIDWIRDLAFLVDMT

GTF2IRD2

746

Q86UP8
SIDWIRDLAFLVDMT

GTF2IRD2B

746

Q6EKJ0
RAAAMERVRQWEIYV

CCDC201

156

A0A1B0GTI1
AAWTRDLAMRVEQFE

DNAH2

4251

Q9P225
DLAMRVEQFELWASR

DNAH2

4256

Q9P225
MDAWVRFSAQSQARE

PEX11B

1

O96011
MSLLERADQRFVWNG

SACM1L

156

Q9NTJ5
VRWMALESLVNNEFS

RYK

506

P34925
LNVRFDSRTMNLSWD

CSF2RA

36

P15509
VALLSVFQAWDDARM

DHX9

916

Q08211
TWREMDIRITDATNE

DNAH5

326

Q8TE73
AFRDLMWDATEGTIR

NPHP1

361

O15259
EFLMEQQRTRNEGAW

ERCC6L

716

Q2NKX8
RNQSLESEQDMRDRW

PPEF1

81

O14829
FRLTSVDLEDWMDVS

OAS3

131

Q9Y6K5
WAEEREATLNNSLMR

KIF13B

671

Q9NQT8
ARMQERARLQEEYWD

RTL1

621

A6NKG5
ASASMDNSVRVWDIR

TAF5L

526

O75529
WEALRVESMDRQSRL

UTRN

401

P46939
TQRRDWDGEAAEMRI

NUGGC

251

Q68CJ6
QEERMSLWATSREFT

TEX14

771

Q8IWB6
DRKEWLTNFMEDRRQ

TOP2B

681

Q02880
WIEQFERDLTRAQMV

SYNE1

326

Q8NF91
EENMDRLRVSLSIWD

SYNE1

2186

Q8NF91
ERMDKRALISFWESV

SNX25

306

Q9H3E2
QRWEAFDVADAMRRH

GDF7

206

Q7Z4P5
QQWFAMLRAEQDREV

GMCL2

366

Q8NEA9
DWLDRLTFREIEMIN

PIK3C3

191

Q8NEB9
NWMRYVVISREEREQ

PRDM11

216

Q9NQV5
FSPETEELQRRWMAV

FGD1

901

P98174
RAELSRESTEMENAW

PLEKHA7

761

Q6IQ23
LSNAMDNTVRVWDVR

SNRNP40

251

Q96DI7
DEMDLDRRAYAVWVS

MUTYH

116

Q9UIF7
RISWAMEDSDLERVT

PHYHIP

21

Q92561
RFSDAWEMCRILNDE

WDR19

661

Q8NEZ3
FLWLRRMQALEREQD

SAPCD1

36

Q5SSQ6
GVREEDLIWAAQAFM

SPATA25

171

Q9BR10
RAENFQELLRSMWAD

SLX4

811

Q8IY92
RRVDENWAEGMLADK

SH3RF1

231

Q7Z6J0
AAMRETWLSENQRLV

SPTBN1

431

Q01082
INRNGEEMRWSFEEL

ACSM3

86

Q53FZ2
AADMRRLDWSDSLAQ

CLEC18A

66

A5D8T8
AADMRRLDWSDSLAQ

CLEC18B

66

Q6UXF7
AADMRRLDWSDSLAQ

CLEC18C

66

Q8NCF0
DVEKGDVRTARWMFE

XIRP2

586

A4UGR9
VWLFENRTFDSIMEA

XIRP2

1316

A4UGR9
RTAVAIADLEWREME

URGCP

31

Q8TCY9
RLDELRMFLENETWE

VPS50

456

Q96JG6
EIRPFRQNWEEADSM

TRAF3

336

Q13114
ERNVMWFVVTALDEI

XPNPEP1

191

Q9NQW7
VMFRDVAVDFSQEEW

ZFP30

6

Q9Y2G7
DMWVRFRAFEAARDL

ZSWIM9

386

Q86XI8
MWLSANLTVQERERF

TMEM179

46

Q6ZVK1
LGSEFLREWEAQDMR

TCTA

21

P57738
TDEELFLMDAQRKWF

TIGD1

456

Q96MW7
AWNRVDIARSEIFMD

TRPM2

461

O94759
TDFEVIQFPLRMRDW

SPARCL1

516

Q14515
EAFSEMTFKQRWVRA

PSTK

296

Q8IV42
VQREARDVWRTYLDM

VPS18

391

Q9P253
VDAWIEMGSRLDARQ

VPS18

611

Q9P253
DAYVRRMAAEATEWQ

SRPK2

226

P78362
VFQRRMDGQTDFWRD

TNXB

4071

P22105
RSDSAFFWEERDIMA

ROCK2

131

O75116
DVARQRELKWLDMFS

TBC1D10B

326

Q4KMP7
AIDWDKTMRFTFNER

TBC1D30

271

Q9Y2I9
AAMRETWLSENQRLV

SPTB

431

P11277
EARVKAELWMRENAE

BRF1

466

Q92994
MFRDVSIDFSQEEWE

ZNF829

36

Q3KNS6
ETFSELRLDSVVQWM

CAD

1561

P27708
WMSDFKVEFLRNELE

PRKDC

3686

P78527
EMIKRSDSAFFWEER

ROCK1

111

Q13464
EEVWARVAMNRQLLD

TMEM209

316

Q96SK2
MAARWSSENVVVEFR

WDR59

1

Q6PJI9
MAFRDVAVDFTQDEW

ZNF133

1

P52736
VINRERMASFERLLW

ATP6V0A4

176

Q9HBG4
MFRDVAVDFSQEEWE

ZNF790

6

Q6PG37
MDEARRWYEEALAIS

TTC7B

746

Q86TV6
FTELFALMERWDALR

TTC29

81

Q8NA56
ALMERWDALREAARV

TTC29

86

Q8NA56
VMFRDVAIDFSQEEW

ZNF420

6

Q8TAQ5
MAALAGVFVWDEERI

STARD7

76

Q9NQZ5
LDMTRYWRQLDDEVA

RCHY1

191

Q96PM5
FSAERTEEWQRMAGV

PIEZO1

1116

Q92508
TEEWQRMAGVNTDRL

PIEZO1

1121

Q92508
WSRVAEMFLFIEERE

TGS1

6

Q96RS0
RRWESADLQEVMFTA

TRPM8

451

Q7Z2W7
FWQFVKETDNEVRMR

WWP1

831

Q9H0M0
NNDFDIKEVRIMRWF

TMEM217

116

Q8N7C4
YRWMIDSRDDFTEER

SDHB

216

P21912
MDEAQREGFWVNLRA

TLR2

766

O60603
QDREFMVFADARWTA

UGT1A7

86

Q9HAW7
MADAWEEIRRLAADF

UFL1

1

O94874
VMFRDVAIDVSQEEW

ZNF461

6

Q8TAF7
REEKFWIMETATQRE

ZNF284

61

Q2VY69
IRSEVEFLKMDFNWR

TMEM39B

271

Q9GZU3
MTEQFLQDTRLALWR

ZSWIM4

306

Q9H7M6
AREEAVFEAAMRWVR

KLHL35

211

Q6PF15
VFEAAMRWVRHDAPA

KLHL35

216

Q6PF15