Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	androstan-3-alpha,17-beta-diol dehydrogenase activity	AKR1C1 AKR1C2 HSD17B10	1.27e-04	9	234	3	GO:0047044
GeneOntologyMolecularFunction	adipokinetic hormone binding	CMKLR1 CMKLR2	1.37e-04	2	234	2	GO:0097004
GeneOntologyMolecularFunction	transferase activity, transferring one-carbon groups	NSD3 SETDB1 PRDM8 MGMT FDXACB1 NTMT1 SHMT1 RRP8 METTL25B NSUN3	3.25e-04	224	234	10	GO:0016741
GeneOntologyMolecularFunction	histone modifying activity	ATR SRCAP NSD3 SETDB1 PRDM8 BRPF1 TAF1 NTMT1 HAT1 SIRT1	3.87e-04	229	234	10	GO:0140993
GeneOntologyMolecularFunction	12-hydroxyheptadecatrienoic acid synthase activity	TBXAS1 PTGES2	4.07e-04	3	234	2	GO:0036134
GeneOntologyMolecularFunction	tRNA binding	ELP5 SARS2 IARS1 NSUN3 EIF5B HSD17B10	5.56e-04	87	234	6	GO:0000049
GeneOntologyMolecularFunction	oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor	AKR1C1 AKR1C2 TBXAS1 PTGES2	6.47e-04	34	234	4	GO:0016628
GeneOntologyMolecularFunction	adipokinetic hormone receptor activity	CMKLR1 CMKLR2	8.08e-04	4	234	2	GO:0097003
GeneOntologyMolecularFunction	indanol dehydrogenase activity	AKR1C1 AKR1C2	8.08e-04	4	234	2	GO:0047718
GeneOntologyMolecularFunction	chlordecone reductase activity	AKR1C1 AKR1C2	8.08e-04	4	234	2	GO:0047743
GeneOntologyMolecularFunction	androsterone dehydrogenase (B-specific) activity	AKR1C1 AKR1C2	8.08e-04	4	234	2	GO:0047042
GeneOntologyMolecularFunction	ketoreductase activity	AKR1C1 AKR1C2	8.08e-04	4	234	2	GO:0045703
GeneOntologyMolecularFunction	adenylate cyclase inhibitor activity	ADGRV1 GNAZ	8.08e-04	4	234	2	GO:0010855
GeneOntologyMolecularFunction	methyltransferase activity	NSD3 SETDB1 PRDM8 MGMT FDXACB1 NTMT1 RRP8 METTL25B NSUN3	9.49e-04	213	234	9	GO:0008168
GeneOntologyMolecularFunction	S-adenosylmethionine-dependent methyltransferase activity	NSD3 SETDB1 PRDM8 FDXACB1 NTMT1 RRP8 METTL25B NSUN3	9.80e-04	172	234	8	GO:0008757
GeneOntologyMolecularFunction	protein serine kinase activity	ATR SGK3 PIK3R4 PHKG1 AKT1 AKT2 TAF1 LRRK1 ULK3 PRKACA PRKACB CSNK2A3	1.25e-03	363	234	12	GO:0106310
GeneOntologyMolecularFunction	trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity	AKR1C1 AKR1C2	1.34e-03	5	234	2	GO:0047115
GeneOntologyMolecularFunction	17-beta-ketosteroid reductase (NADPH) activity	AKR1C1 AKR1C2	1.34e-03	5	234	2	GO:0072555
GeneOntologyMolecularFunction	lithocholic acid binding	AKR1C1 AKR1C2	1.34e-03	5	234	2	GO:1902121
GeneOntologyMolecularFunction	Delta4-3-oxosteroid 5beta-reductase activity	AKR1C1 AKR1C2	1.34e-03	5	234	2	GO:0047787
GeneOntologyMolecularFunction	15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity	AKR1C1 AKR1C2	1.34e-03	5	234	2	GO:0047020
GeneOntologyMolecularFunction	17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity	AKR1C1 AKR1C2	1.34e-03	5	234	2	GO:0047006
GeneOntologyMolecularFunction	ketosteroid monooxygenase activity	AKR1C1 AKR1C2	1.34e-03	5	234	2	GO:0047086
GeneOntologyMolecularFunction	cyclase inhibitor activity	ADGRV1 GNAZ	1.34e-03	5	234	2	GO:0010852
GeneOntologyMolecularFunction	estradiol 17-beta-dehydrogenase [NAD(P)+] activity	AKR1C1 AKR1C2 HSD17B10	1.56e-03	20	234	3	GO:0004303
GeneOntologyBiologicalProcess	cellular response to calcium ion	ADGRV1 AKR1C1 AKR1C2 CPNE6 PLCG2 RASAL1 CAPN3 MCOLN1	5.93e-06	88	228	8	GO:0071277
GeneOntologyBiologicalProcess	positive regulation of glucose metabolic process	INSR PHKG1 DGAT2 AKT1 AKT2 SIRT1 PRKACA	6.69e-06	64	228	7	GO:0010907
GeneOntologyBiologicalProcess	carbohydrate biosynthetic process	B3GALNT1 INSR PHKG1 DGAT2 AKT1 AKT2 CHST10 NTSR1 SIRT1 CHST8 PRKACA PGM2	2.09e-05	247	228	12	GO:0016051
GeneOntologyBiologicalProcess	positive regulation of carbohydrate metabolic process	INSR PHKG1 DGAT2 AKT1 AKT2 NTSR1 SIRT1 PRKACA	2.19e-05	105	228	8	GO:0045913
GeneOntologyBiologicalProcess	cellular response to metal ion	HFE SERPINF1 ADGRV1 AKR1C1 AKR1C2 CPNE6 AKT1 PLCG2 RASAL1 CAPN3 MCOLN1	3.41e-05	219	228	11	GO:0071248
GeneOntologyBiologicalProcess	methylation	NSD3 SETDB1 PRDM8 MGMT AKT1 FDXACB1 NTMT1 RRP8 METTL25B NSUN3 HSD17B10	6.23e-05	234	228	11	GO:0032259
Domain	ARM-type_fold	RALGAPA1 ATR NCBP1 CUL7 ITPR1 PIK3R4 PIK3CD RIC8A TANGO6 IPO8 RANBP6 XPO1 RALGAPA2 PPP4R4 INTS4	2.13e-05	339	230	15	IPR016024
Domain	HEAT_REPEAT	ATR PIK3R4 TANGO6 RANBP6 XPO1 PPP4R4 INTS4	2.43e-05	70	230	7	PS50077
Domain	BROMODOMAIN_1	BRWD3 BRD8 BRPF1 TAF1 TRIM33	8.57e-05	37	230	5	PS00633
Domain	Bromodomain	BRWD3 BRD8 BRPF1 TAF1 TRIM33	9.77e-05	38	230	5	PF00439
Domain	BROMODOMAIN_2	BRWD3 BRD8 BRPF1 TAF1 TRIM33	1.42e-04	41	230	5	PS50014
Domain	SYNAPTOP	SYNPR SYP	1.51e-04	2	230	2	PS00604
Domain	Bromodomain	BRWD3 BRD8 BRPF1 TAF1 TRIM33	1.59e-04	42	230	5	IPR001487
Domain	-	BRWD3 BRD8 BRPF1 TAF1 TRIM33	1.59e-04	42	230	5	1.20.920.10
Domain	BROMO	BRWD3 BRD8 BRPF1 TAF1 TRIM33	1.59e-04	42	230	5	SM00297
Pathway	KEGG_INSULIN_SIGNALING_PATHWAY	PDE3A ACACB INSR PHKG1 PIK3CD AKT1 AKT2 EXOC7 PRKACA PRKACB	8.76e-06	137	177	10	M18155
Pathway	REACTOME_SYNTHESIS_OF_PROSTAGLANDINS_PG_AND_THROMBOXANES_TX	AKR1C1 AKR1C2 TBXAS1 PTGES2	2.94e-05	15	177	4	MM14870
Pathway	WP_RESISTIN_AS_A_REGULATOR_OF_INFLAMMATION	ITPR1 PIK3CD AKT1 AKT2 PLCG2	5.26e-05	33	177	5	M39745
Pathway	KEGG_MEDICUS_REFERENCE_ACH_CHRN_PI3K_SIGNALING_PATHWAY	PIK3CD AKT1 AKT2	6.56e-05	7	177	3	M47790
Pathway	KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION	PDE3A PIK3CD AKT1 AKT2 ANAPC4 PRKACA PRKACB	9.46e-05	85	177	7	M3578
Pathway	KEGG_MEDICUS_VARIANT_AMPLIFIED_PDGFR_TO_PI3K_SIGNALING_PATHWAY	PIK3CD AKT1 AKT2	1.04e-04	8	177	3	M47399
Pathway	KEGG_MEDICUS_VARIANT_AMPLIFIED_EGFR_TO_PI3K_SIGNALING_PATHWAY	PIK3CD AKT1 AKT2	1.04e-04	8	177	3	M47394
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_EGFR_TO_PI3K_SIGNALING_PATHWAY	PIK3CD AKT1 AKT2	1.04e-04	8	177	3	M47395
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_KIT_TO_PI3K_SIGNALING_PATHWAY	PIK3CD AKT1 AKT2	1.04e-04	8	177	3	M47404
Pathway	KEGG_MEDICUS_VARIANT_EML4_ALK_FUSION_KINASE_TO_PI3K_SIGNALING_PATHWAY	PIK3CD AKT1 AKT2	1.04e-04	8	177	3	M47405
Pathway	KEGG_MEDICUS_REFERENCE_P4_PR_PI3K_SIGNALING_PATHWAY	PIK3CD AKT1 AKT2	1.04e-04	8	177	3	M47803
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_RET_TO_PI3K_SIGNALING_PATHWAY	PIK3CD AKT1 AKT2	1.04e-04	8	177	3	M47715
Pathway	KEGG_MEDICUS_VARIANT_TGFA_OVEREXPRESSION_TO_PI3K_SIGNALING_PATHWAY	PIK3CD AKT1 AKT2	1.04e-04	8	177	3	M47482
Pathway	KEGG_MEDICUS_VARIANT_EGF_OVEREXPRESSION_TO_PI3K_SIGNALING_PATHWAY	PIK3CD AKT1 AKT2	1.04e-04	8	177	3	M47498
Pathway	KEGG_MEDICUS_VARIANT_AMPLIFIED_FGFR_TO_PI3K_SIGNALING_PATHWAY	PIK3CD AKT1 AKT2	1.55e-04	9	177	3	M47397
Pathway	KEGG_MEDICUS_REFERENCE_EGF_EGFR_PI3K_SIGNALING_PATHWAY	PIK3CD AKT1 AKT2	1.55e-04	9	177	3	M47392
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_KRAS_NRAS_TO_PI3K_SIGNALING_PATHWAY	PIK3CD AKT1 AKT2	1.55e-04	9	177	3	M47391
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_MET_TO_PI3K_SIGNALING_PATHWAY	PIK3CD AKT1 AKT2	1.55e-04	9	177	3	M47402
Pathway	KEGG_MEDICUS_REFERENCE_MEMBRANE_INITIATED_PROGESTERONE_SIGNALING_PATHWAY	PIK3CD AKT1 AKT2	1.55e-04	9	177	3	M47802
Pathway	REACTOME_ESTROGEN_DEPENDENT_NUCLEAR_EVENTS_DOWNSTREAM_OF_ESR_MEMBRANE_SIGNALING	AKT1 AKT2 XPO1	1.55e-04	9	177	3	MM15666
Pathway	KEGG_MEDICUS_VARIANT_AMPLIFIED_MET_TO_PI3K_SIGNALING_PATHWAY	PIK3CD AKT1 AKT2	1.55e-04	9	177	3	M47490
Pathway	KEGG_MEDICUS_REFERENCE_TGFA_EGFR_PI3K_SIGNALING_PATHWAY	PIK3CD AKT1 AKT2	1.55e-04	9	177	3	M47481
Pathway	KEGG_MEDICUS_REFERENCE_ICOSLG_ICOS_PI3K_SIGNALING_PATHWAY	PIK3CD AKT1 AKT2	1.55e-04	9	177	3	M47972
Pathway	WP_AMPACTIVATED_PROTEIN_KINASE_SIGNALING	ACACB INSR PIK3CD AKT1 AKT2 PRKACB	1.90e-04	67	177	6	M39630
Pathway	KEGG_MEDICUS_VARIANT_EGFR_OVEREXPRESSION_TO_PI3K_SIGNALING_PATHWAY	PIK3CD AKT1 AKT2	2.19e-04	10	177	3	M47400
Pathway	KEGG_MEDICUS_REFERENCE_HGF_MET_PI3K_SIGNALING_PATHWAY	PIK3CD AKT1 AKT2	2.19e-04	10	177	3	M47401
Pathway	KEGG_MEDICUS_REFERENCE_CD80_CD86_CD28_PI3K_SIGNALING_PATHWAY	PIK3CD AKT1 AKT2	2.19e-04	10	177	3	M47615
Pathway	WP_RELATIONSHIP_BETWEEN_INFLAMMATION_COX2_AND_EGFR	PIK3CD AKT1 AKT2 PTGES2	2.47e-04	25	177	4	M39794
Pathway	SIG_BCR_SIGNALING_PATHWAY	ITPR1 PIK3CD AKT1 AKT2 PLCG2	2.66e-04	46	177	5	M8626
Pathway	REACTOME_FERTILIZATION	SPAM1 IZUMO4 OVGP1 CATSPER2	2.89e-04	26	177	4	M26922
Pathway	KEGG_MEDICUS_ENV_FACTOR_NICOTINE_NNK_TO_PI3K_SIGNALING_PATHWAY	PIK3CD AKT1 AKT2	2.98e-04	11	177	3	M47797
Pathway	KEGG_MEDICUS_REFERENCE_KITLG_KIT_PI3K_SIGNALING_PATHWAY	PIK3CD AKT1 AKT2	2.98e-04	11	177	3	M47403
Pathway	KEGG_MEDICUS_VARIANT_BCR_ABL_FUSION_KINASE_TO_PI3K_SIGNALING_PATHWAY	PIK3CD AKT1 AKT2	2.98e-04	11	177	3	M47406
Pathway	KEGG_MEDICUS_REFERENCE_NRG_ERBB4_PI3K_SIGNALING_PATHWAY	PIK3CD AKT1 AKT2	2.98e-04	11	177	3	M47756
Pathway	KEGG_MEDICUS_ENV_FACTOR_NNK_NNN_TO_PI3K_SIGNALING_PATHWAY_N01339	PIK3CD AKT1 AKT2	2.98e-04	11	177	3	M47791
Pathway	KEGG_MEDICUS_REFERENCE_IGF2_IGF1R_PI3K_SIGNALING_PATHWAY	PIK3CD AKT1 AKT2	2.98e-04	11	177	3	M47484
Pathway	KEGG_MEDICUS_REFERENCE_EREG_EGFR_PI3K_SIGNALING_PATHWAY	PIK3CD AKT1 AKT2	2.98e-04	11	177	3	M47499
Pathway	KEGG_MEDICUS_REFERENCE_AREG_EGFR_PI3K_SIGNALING_PATHWAY	PIK3CD AKT1 AKT2	2.98e-04	11	177	3	M47501
Pathway	KEGG_MEDICUS_VARIANT_ERBB2_OVEREXPRESSION_TO_PI3K_SIGNALING_PATHWAY	PIK3CD AKT1 AKT2	3.94e-04	12	177	3	M47393
Pathway	KEGG_MEDICUS_ENV_FACTOR_NNK_NNN_TO_PI3K_SIGNALING_PATHWAY_N01350	PIK3CD AKT1 AKT2	3.94e-04	12	177	3	M47798
Pathway	WP_RESOLVIN_E1_AND_RESOLVIN_D1_SIGNALING_DECREASE_INFLAMMATION	PIK3CD AKT1 CMKLR1	3.94e-04	12	177	3	M45559
Pathway	KEGG_MEDICUS_REFERENCE_CXCR4_GNAI_PI3K_BAD_SIGNALING_PATHWAY	PIK3CD AKT1 AKT2	3.94e-04	12	177	3	M47558
Pathway	KEGG_MEDICUS_PATHOGEN_HIV_GP120_TO_CXCR4_GNAI_PI3K_BAD_SIGNALING_PATHWAY	PIK3CD AKT1 AKT2	3.94e-04	12	177	3	M47559
Pathway	WP_LIPID_METABOLISM_PATHWAY	AKT1 AKT2 PRKACA PRKACB	4.46e-04	29	177	4	M39762
Pathway	KEGG_MEDICUS_REFERENCE_PDGF_PDGFR_PI3K_SIGNALING_PATHWAY	PIK3CD AKT1 AKT2	5.07e-04	13	177	3	M47398
Pathway	KEGG_MEDICUS_REFERENCE_IGF_IGF1R_PI3K_SIGNALING_PATHWAY	PIK3CD AKT1 AKT2	5.07e-04	13	177	3	M47603
Pathway	WP_GPR143_IN_MELANOCYTES_AND_RETINAL_PIGMENT_EPITHELIUM_CELLS	SERPINF1 ITPR1 PRKACA PRKACB	5.10e-04	30	177	4	M42578
Pathway	REACTOME_REPRODUCTION	SPAM1 IZUMO4 OVGP1 CATSPER2	5.10e-04	30	177	4	MM17211
Pathway	KEGG_MEDICUS_VARIANT_DUPLICATION_OR_MUTATION_ACTIVATED_FLT3_TO_RAS_PI3K_SIGNALING_PATHWAY	PIK3CD AKT1 AKT2	6.40e-04	14	177	3	M47390
Pathway	KEGG_MEDICUS_REFERENCE_IGF_IGFR_PI3K_NFKB_SIGNALING_PATHWAY	PIK3CD AKT1 AKT2	6.40e-04	14	177	3	M47467
Pathway	KEGG_MEDICUS_REFERENCE_EGF_EGFR_PI3K_NFKB_SIGNALING_PATHWAY	PIK3CD AKT1 AKT2	6.40e-04	14	177	3	M47536
Pathway	KEGG_MEDICUS_REFERENCE_EGF_EGFR_RAS_PI3K_SIGNALING_PATHWAY	PIK3CD AKT1 AKT2	7.92e-04	15	177	3	M47389
Pathway	KEGG_MEDICUS_REFERENCE_RELN_VLDLR_PI3K_SIGNALING_PATHWAY	PIK3CD AKT1 AKT2	7.92e-04	15	177	3	M47663
Pathway	KEGG_MEDICUS_REFERENCE_FLT3LG_FLT3_RAS_PI3K_SIGNALING_PATHWAY	PIK3CD AKT1 AKT2	7.92e-04	15	177	3	M47475
Pathway	KEGG_MEDICUS_REFERENCE_BCR_BCAP_CD19_PI3K_SIGNALING_PATHWAY	PIK3CD AKT1 AKT2	7.92e-04	15	177	3	M47971
Pathway	WP_G_PROTEIN_SIGNALING_PATHWAYS	PDE7A ITPR1 GNAZ PDE8B PRKACA PRKACB	9.37e-04	90	177	6	MM15882
Pathway	WP_G_PROTEIN_SIGNALING	PDE7A ITPR1 GNAZ PDE8B PRKACA PRKACB	9.93e-04	91	177	6	M39426
Pathway	REACTOME_REGULATION_OF_INSULIN_SECRETION	ITPR1 ADRA2A ABCC8 PRKACA PRKACB	9.94e-04	61	177	5	MM15071
Pathway	SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES	ITPR1 AKT1 AKT2 PLCG2	1.03e-03	36	177	4	M1315
Pathway	SA_PTEN_PATHWAY	PIK3CD AKT1 AKT2	1.16e-03	17	177	3	M12771
Pathway	SA_TRKA_RECEPTOR	PIK3CD AKT1 AKT2	1.16e-03	17	177	3	M18895
Pathway	REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_KEY_METABOLIC_FACTORS	PRKACA PRKACB	1.53e-03	5	177	2	M26988
Pathway	KEGG_MEDICUS_VARIANT_LOSS_OF_NKX3_1_TO_PI3K_SIGNALING_PATHWAY	AKT1 AKT2	1.53e-03	5	177	2	M48999
Pathway	WP_NEURAL_CREST_CELL_MIGRATION_DURING_DEVELOPMENT	PIK3R4 PIK3CD AKT1 AKT2	1.54e-03	40	177	4	M39798
Pathway	WP_KCNQ2RELATED_EPILEPSIES	ITPR1 PLCG2 PRKACA	1.63e-03	19	177	3	M48320
Pathway	KEGG_MEDICUS_REFERENCE_PP2A_AKT_SIGNALING_PATHWAY	AKT1 AKT2 PPP2R3A	1.63e-03	19	177	3	M47525
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	RALGAPA1 ARHGAP32 EMC1 ELP5 NCBP1 CUL7 NSD3 ITPR1 FBXO38 LONP1 ZFYVE9 SSH1 SEC24B UTRN CCDC14 JCAD HYOU1 PTPN23 XPO1 PPP4R4 PPP2R3A PRKACA INTS4 CNOT1 PTPN20 DCP1A	1.41e-08	1049	235	26	27880917
Pubmed	Defining the human deubiquitinating enzyme interaction landscape.	MYO1A SF3A1 MCM4 FBXO38 LONP1 SARS2 CTPS2 USP38 UTRN CCDC14 DSC1 NEDD4L USP28 POLA1 IARS1 TAF1B HAT1 BEND3 RRP8 SIRT1 PRKACA UGGT2 CNOT1 GPN3 DCP1A	2.54e-08	1005	235	25	19615732
Pubmed	A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.	ARHGAP32 HECW1 ELP5 PEG3 SETDB1 RIC8A TAF1 CCDC14 FAT4 IPO8 ATN1 TEX11 PPP2R3A ATP6V0D1 CELF2 CELF3 ZBED1 RAI2 KLHL26	4.07e-08	608	235	19	16713569
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	ARHGAP32 HECW1 CUL7 ALMS1 SSH1 TULP4 WDR35 EXOC7 TANGO6 PTPN23 RALGAPA2 ATP10A PPP4R4 GDA NPHP3 ATRNL1 EIF5B	5.32e-08	493	235	17	15368895
Pubmed	Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers.	HECW1 INSR LRP1B NSD3 DMXL1 SGK3 SSH1 ADAMTS15 AKT1 AKT2 TAF1 HCFC2 ATP8B3 TENT4B CAPN3 SHMT1 ULK3 OVGP1 PRKACA PRKACB	1.49e-07	730	235	20	34857952
Pubmed	Protein kinase B/Akt phosphorylation of PDE3A and its role in mammalian oocyte maturation.	PDE3A AKT1 PRKACA	3.05e-07	3	235	3	17124499
Pubmed	Combined PI3K/Akt and Hsp90 targeting synergistically suppresses essential functions of alloreactive T cells and increases Tregs.	PIK3CD AKT1 AKT2	3.05e-07	3	235	3	26265781
Pubmed	Akt/PKB interacts with the histone H3 methyltransferase SETDB1 and coordinates to silence gene expression.	SETDB1 AKT1 AKT2	3.05e-07	3	235	3	17577629
Pubmed	Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.	MYADM PDE7A NCBP1 ARSI TULP1 DMXL1 ITPR1 NPFFR2 PXDN PIK3CD AKT1 AKT2 ZNHIT2 UTRN FDXACB1 CCDC14 POLA1 NTMT1 CLDN6 TUBGCP6 TRIM33 CELF2 TENM1 RSBN1L DCP1A	8.83e-07	1215	235	25	15146197
Pubmed	HIV-1 Tat protein down-regulates CREB transcription factor expression in PC12 neuronal cells through a phosphatidylinositol 3-kinase/AKT/cyclic nucleoside phosphodiesterase pathway.	PDE3A PDE7A PIK3CD AKT1 AKT2	9.65e-07	27	235	5	11156964
Pubmed	Insulin Is Required to Maintain Albumin Expression by Inhibiting Forkhead Box O1 Protein.	INSR AKT1 AKT2	1.21e-06	4	235	3	26668316
Pubmed	Inhibition of nuclear import by protein kinase B (Akt) regulates the subcellular distribution and activity of the forkhead transcription factor AFX.	AKT1 AKT2 XPO1	1.21e-06	4	235	3	11313479
Pubmed	The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation.	MCM4 NCBP1 LONP1 RIC8A RAD21 HYOU1 IPO8 POLA1 IARS1 HAT1 PTPN23 XPO1 TRIM33 EIF5B HSD17B10 CSNK2A3 CNOT1	1.92e-06	638	235	17	33239621
Pubmed	Chemokine coreceptor signaling in HIV-1 infection and pathogenesis.	PIK3CD AKT1 AKT2 PLCG2	1.93e-06	14	235	4	20041213
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	SPAM1 CUL7 SRCAP BRWD3 NSD3 SETDB1 BRD8 ALMS1 BRPF1 RIC8A TAF1 ANAPC4 ATN1 SAP30L BEND3 RALGAPA2 SIRT1 TUBGCP6 TRIM33 POLDIP2 CSMD1 RSBN1L SENP7	2.41e-06	1116	235	23	31753913
Pubmed	Overexpressing PKIB in prostate cancer promotes its aggressiveness by linking between PKA and Akt pathways.	AKT1 PRKACA PRKACB	3.02e-06	5	235	3	19483721
Pubmed	The CELF family of RNA binding proteins is implicated in cell-specific and developmentally regulated alternative splicing.	CELF5 CELF2 CELF3	6.00e-06	6	235	3	11158314
Pubmed	Heart 6-phosphofructo-2-kinase activation by insulin requires PKB (protein kinase B), but not SGK3 (serum- and glucocorticoid-induced protein kinase 3).	SGK3 AKT1 AKT2	6.00e-06	6	235	3	20687898
Pubmed	Insulin receptor signaling in cones.	INSR AKT1 AKT2	6.00e-06	6	235	3	23673657
Pubmed	A family of human RNA-binding proteins related to the Drosophila Bruno translational regulator.	CELF5 CELF2 CELF3	6.00e-06	6	235	3	10893231
Pubmed	Insulin- and Lipopolysaccharide-Mediated Signaling in Adipose Tissue Macrophages Regulates Postprandial Glycemia through Akt-mTOR Activation.	INSR AKT1 AKT2	6.00e-06	6	235	3	32464093
Pubmed	A Ral GAP complex links PI 3-kinase/Akt signaling to RalA activation in insulin action.	AKT2 EXOC7 RALGAPA2	1.04e-05	7	235	3	21148297
Pubmed	Protein kinase B controls transcriptional programs that direct cytotoxic T cell fate but is dispensable for T cell metabolism.	PIK3CD AKT1 AKT2	1.04e-05	7	235	3	21295499
Pubmed	Direct evidence for the action of phosphatidylinositol (3,4,5)-trisphosphate-mediated signal transduction in the 2-cell mouse embryo.	AKT1 AKT2 PLCG2	1.04e-05	7	235	3	17634444
Pubmed	Physiogenomic comparison of edema and BMI in patients receiving rosiglitazone or pioglitazone.	ACACB INSR ADRA2A PIK3CD ABCC8 AKT1 AKT2	1.55e-05	117	235	7	18996102
Pubmed	HSF1 phosphorylation establishes an active chromatin state via the TRRAP-TIP60 complex and promotes tumorigenesis.	RBM12B MCM4 AKR1C1 AKR1C2 ITPR1 SEC24B PLCG2 TANGO6 PPP1R21 JCAD FAT4 IPO8 DSC1 IARS1 PTPN23 SEC22A TRIM33	1.70e-05	754	235	17	35906200
Pubmed	DNA sequence and analysis of human chromosome 8.	IQANK1 EBF2 ADCK5 ZNF596 CSMD1	1.82e-05	48	235	5	16421571
Pubmed	A conserved acetylation switch enables pharmacological control of tubby-like protein stability.	CUL7 TULP1 SARS2 WDR35 HAT1 BEND3 SIRT1 ZBED1 SENP7	2.30e-05	223	235	9	33187986
Pubmed	Ellis-van Creveld Syndrome	WDR35 PRKACA PRKACB	2.48e-05	9	235	3	37903214
Pubmed	Novel PI3K/Akt inhibitors screened by the cytoprotective function of human immunodeficiency virus type 1 Tat.	PIK3CD AKT1 AKT2	2.48e-05	9	235	3	21765914
Pubmed	TIF1γ inhibits lung adenocarcinoma EMT and metastasis by interacting with the TAF15/TBP complex.	SF3A1 MCM4 HYOU1 IARS1 XPO1 TRIM33 EIF5B DCP1A	3.19e-05	179	235	8	36261009
Pubmed	Claudin association with CD81 defines hepatitis C virus entry.	CLDN17 CLDN6 CLDN9	3.53e-05	10	235	3	20375010
Pubmed	Phosphorylation and inactivation of glycogen synthase kinase 3 by protein kinase A.	SGK3 AKT1 PRKACA	3.53e-05	10	235	3	11035810
Pubmed	Sulfation of the human immunodeficiency virus envelope glycoprotein.	CHST7 CHST10 CHST8	3.53e-05	10	235	3	1433500
Pubmed	Convergence of multiple signaling cascades at glycogen synthase kinase 3: Edg receptor-mediated phosphorylation and inactivation by lysophosphatidic acid through a protein kinase C-dependent intracellular pathway.	SGK3 AKT1 PRKACA	3.53e-05	10	235	3	11884598
Pubmed	Combinatorial CRISPR screen identifies fitness effects of gene paralogues.	ATR UPF3A SLC25A37 USP38 SEC24B RAD21 RANBP6 DCP1A	4.19e-05	186	235	8	33637726
Pubmed	Different functions of AKT1 and AKT2 in molecular pathways, cell migration and metabolism in colon cancer cells.	AKT1 AKT2	4.55e-05	2	235	2	27878243
Pubmed	BAY 1125976, a selective allosteric AKT1/2 inhibitor, exhibits high efficacy on AKT signaling-dependent tumor growth in mouse models.	AKT1 AKT2	4.55e-05	2	235	2	27699769
Pubmed	Mutant LGI1 inhibits seizure-induced trafficking of Kv4.2 potassium channels.	KCND2 LGI1	4.55e-05	2	235	2	22122031
Pubmed	Isoform-Specific Role of Akt in Oral Squamous Cell Carcinoma.	AKT1 AKT2	4.55e-05	2	235	2	31252679
Pubmed	Relationship of human liver dihydrodiol dehydrogenases to hepatic bile-acid-binding protein and an oxidoreductase of human colon cells.	AKR1C1 AKR1C2	4.55e-05	2	235	2	8573067
Pubmed	Claudin-6 and claudin-9 function as additional coreceptors for hepatitis C virus.	CLDN6 CLDN9	4.55e-05	2	235	2	17804490
Pubmed	Evidence for a second isoform of the catalytic subunit of cAMP-dependent protein kinase.	PRKACA PRKACB	4.55e-05	2	235	2	3023318
Pubmed	Expression of AKT1 along with AKT2 in granulosa-lutein cells of hyperandrogenic PCOS patients.	AKT1 AKT2	4.55e-05	2	235	2	28271235
Pubmed	Knockout of Akt1/2 suppresses the metastasis of human prostate cancer cells CWR22rv1 in vitro and in vivo.	AKT1 AKT2	4.55e-05	2	235	2	33377281
Pubmed	Akt2 mRNA is highly expressed in embryonic brown fat and the AKT2 kinase is activated by insulin.	AKT1 AKT2	4.55e-05	2	235	2	9620559
Pubmed	Akt1 and Akt2 differently regulate muscle creatine kinase and myogenin gene transcription in insulin-induced differentiation of C2C12 myoblasts.	AKT1 AKT2	4.55e-05	2	235	2	11861503
Pubmed	Reducing Akt2 in retinal pigment epithelial cells causes a compensatory increase in Akt1 and attenuates diabetic retinopathy.	AKT1 AKT2	4.55e-05	2	235	2	36229454
Pubmed	Molecular cloning of the akt oncogene and its human homologues AKT1 and AKT2: amplification of AKT1 in a primary human gastric adenocarcinoma.	AKT1 AKT2	4.55e-05	2	235	2	3037531
Pubmed	High-intensity muscle contraction-mediated increases in Akt1 and Akt2 phosphorylation do not contribute to mTORC1 activation and muscle protein synthesis.	AKT1 AKT2	4.55e-05	2	235	2	32078465
Pubmed	Loss of Akt1 or Akt2 delays mammary tumor onset and suppresses tumor growth rate in MTB-IGFIR transgenic mice.	AKT1 AKT2	4.55e-05	2	235	2	23919516
Pubmed	Cutaneous human papillomaviruses down-regulate AKT1, whereas AKT2 up-regulation and activation associates with tumors.	AKT1 AKT2	4.55e-05	2	235	2	17804734
Pubmed	Lack of AKT in adipocytes causes severe lipodystrophy.	AKT1 AKT2	4.55e-05	2	235	2	27408773
Pubmed	Isoform-specific requirement for Akt1 in the developmental regulation of cellular metabolism during lactation.	AKT1 AKT2	4.55e-05	2	235	2	17141631
Pubmed	PI3K/AKT Signaling in Breast Cancer Molecular Subtyping and Lymph Node Involvement.	AKT1 AKT2	4.55e-05	2	235	2	31781306
Pubmed	Distinct actions of akt1 on skeletal architecture and function.	AKT1 AKT2	4.55e-05	2	235	2	24663486
Pubmed	Central expression of synaptophysin and synaptoporin in nociceptive afferent subtypes in the dorsal horn.	SYNPR SYP	4.55e-05	2	235	2	30862809
Pubmed	Investigation of -PRKACA/-PRKACB fusion genes in oncocytic tumors of the pancreatobiliary and other systems.	PRKACA PRKACB	4.55e-05	2	235	2	36152045
Pubmed	rac regulates its effector phospholipase Cgamma2 through interaction with a split pleckstrin homology domain.	AKT1 PLCG2	4.55e-05	2	235	2	18728011
Pubmed	Akt1 and akt2 play distinct roles in the initiation and metastatic phases of mammary tumor progression.	AKT1 AKT2	4.55e-05	2	235	2	19491266
Pubmed	The cAMP/PKA pathway rapidly activates SIRT1 to promote fatty acid oxidation independently of changes in NAD(+).	SIRT1 PRKACA	4.55e-05	2	235	2	22195961
Pubmed	Polymorphisms in PI3K/AKT genes and gene‑smoking interaction are associated with susceptibility to tuberculosis.	PIK3CD AKT1	4.55e-05	2	235	2	38117222
Pubmed	Depletion of Akt1 and Akt2 Impairs the Repair of Radiation-Induced DNA Double Strand Breaks via Homologous Recombination.	AKT1 AKT2	4.55e-05	2	235	2	31847370
Pubmed	Akt signaling mediates postnatal heart growth in response to insulin and nutritional status.	INSR AKT1	4.55e-05	2	235	2	12163490
Pubmed	Modeling single nucleotide polymorphisms in the human AKR1C1 and AKR1C2 genes: implications for functional and genotyping analyses.	AKR1C1 AKR1C2	4.55e-05	2	235	2	21217827
Pubmed	Loss of CSMD1 or 2 may contribute to the poor prognosis of colorectal cancer patients.	CSMD2 CSMD1	4.55e-05	2	235	2	24408017
Pubmed	Role of AMPK and Akt in triple negative breast cancer lung colonization.	AKT1 AKT2	4.55e-05	2	235	2	33839456
Pubmed	Molecular alterations in AKT and its protein activation in human lung carcinomas.	AKT1 AKT2	4.55e-05	2	235	2	22748472
Pubmed	Synaptic vesicle protein synaptoporin is differently expressed by subpopulations of mouse hippocampal neurons.	SYNPR SYP	4.55e-05	2	235	2	12271488
Pubmed	Akt deficiency impairs normal cell proliferation and suppresses oncogenesis in a p53-independent and mTORC1-dependent manner.	AKT1 AKT2	4.55e-05	2	235	2	17045205
Pubmed	Characterization of genomic clones coding for the C alpha and C beta subunits of mouse cAMP-dependent protein kinase.	PRKACA PRKACB	4.55e-05	2	235	2	2833513
Pubmed	Akt1 and Akt2 Isoforms Play Distinct Roles in Regulating the Development of Inflammation and Fibrosis Associated with Alcoholic Liver Disease.	AKT1 AKT2	4.55e-05	2	235	2	31671832
Pubmed	PKB signaling and atrogene expression in skeletal muscle of aged mice.	AKT1 AKT2	4.55e-05	2	235	2	21551011
Pubmed	ATP binding to a unique site in the type-1 S2- inositol 1,4,5-trisphosphate receptor defines susceptibility to phosphorylation by protein kinase A.	ITPR1 PRKACA	4.55e-05	2	235	2	16621795
Pubmed	Distinct and specific roles of AKT1 and AKT2 in androgen-sensitive and androgen-independent prostate cancer cells.	AKT1 AKT2	4.55e-05	2	235	2	23567263
Pubmed	Distinct roles of Akt1 and Akt2 in regulating cell migration and epithelial-mesenchymal transition.	AKT1 AKT2	4.55e-05	2	235	2	16365168
Pubmed	Prognostic significance of activated Akt expression in pancreatic ductal adenocarcinoma.	AKT1 AKT2	4.55e-05	2	235	2	15102693
Pubmed	AKT1 and AKT2 induce distinct phosphorylation patterns in HL-1 cardiac myocytes.	AKT1 AKT2	4.55e-05	2	235	2	25162660
Pubmed	Functional analysis of claudin-6 and claudin-9 as entry factors for hepatitis C virus infection of human hepatocytes by using monoclonal antibodies.	CLDN6 CLDN9	4.55e-05	2	235	2	23864633
Pubmed	Distinct actions of Akt1 and Akt2 in skeletal muscle differentiation.	AKT1 AKT2	4.55e-05	2	235	2	19142853
Pubmed	Akt1/Akt2 and mammalian target of rapamycin/Bim play critical roles in osteoclast differentiation and survival, respectively, whereas Akt is dispensable for cell survival in isolated osteoclast precursors.	AKT1 AKT2	4.55e-05	2	235	2	15545269
Pubmed	Loss of PKBβ/Akt2 predisposes mice to ovarian cyst formation and increases the severity of polycystic ovary formation in vivo.	AKT1 AKT2	4.55e-05	2	235	2	22275470
Pubmed	Interference with XPO1 Suppresses the Stemness and Radioresistance of CD44 Positive Cervical Cancer Cells via Binding with Rad21.	RAD21 XPO1	4.55e-05	2	235	2	37094850
Pubmed	Akt1 and Akt2 protein kinases differentially contribute to macrophage polarization.	AKT1 AKT2	4.55e-05	2	235	2	22647600
Pubmed	CD133 promotes gallbladder carcinoma cell migration through activating Akt phosphorylation.	PROM1 AKT1	4.55e-05	2	235	2	26910892
Pubmed	Akt isoform-specific inhibition of MDA-MB-231 cell proliferation.	AKT1 AKT2	4.55e-05	2	235	2	20688159
Pubmed	Stability and function of adult vasculature is sustained by Akt/Jagged1 signalling axis in endothelium.	AKT1 AKT2	4.55e-05	2	235	2	26971877
Pubmed	AKT methylation by SETDB1 promotes AKT kinase activity and oncogenic functions.	SETDB1 AKT1	4.55e-05	2	235	2	30692625
Pubmed	Simvastatin ameliorates ionizing radiation-induced apoptosis in the thymus by activating the AKT/sirtuin 1 pathway in mice.	AKT1 SIRT1	4.55e-05	2	235	2	28677744
Pubmed	Akt as a target for cancer therapy: more is not always better (lessons from studies in mice).	AKT1 AKT2	4.55e-05	2	235	2	28557977
Pubmed	Redundant roles of AKT1 and AKT2 in fertility, estrous cyclicity and endometrial gland development.	AKT1 AKT2	4.55e-05	2	235	2	37053038
Pubmed	Roles of AKT1 and AKT2 in non-small cell lung cancer cell survival, growth, and migration.	AKT1 AKT2	4.55e-05	2	235	2	21722267
Pubmed	Progesterone potentiates calcium release through IP3 receptors by an Akt-mediated mechanism in hippocampal neurons.	ITPR1 AKT1	4.55e-05	2	235	2	19081133
Pubmed	Opposing Actions of AKT (Protein Kinase B) Isoforms in Vascular Smooth Muscle Injury and Therapeutic Response.	AKT1 AKT2	4.55e-05	2	235	2	29025710
Pubmed	Recurrent Rearrangements in PRKACA and PRKACB in Intraductal Oncocytic Papillary Neoplasms of the Pancreas and Bile Duct.	PRKACA PRKACB	4.55e-05	2	235	2	31678302
Pubmed	Decreased spermatogenesis, fertility, and altered Slc2A expression in Akt1-/- and Akt2-/- testes and sperm.	AKT1 AKT2	4.55e-05	2	235	2	22228739
Pubmed	Alternative AKT2 splicing produces protein lacking the hydrophobic motif regulatory region.	AKT1 AKT2	4.55e-05	2	235	2	33253205
Pubmed	Systems-level identification of PKA-dependent signaling in epithelial cells.	PRKACA PRKACB	4.55e-05	2	235	2	28973931
Pubmed	IL-7 promotes Glut1 trafficking and glucose uptake via STAT5-mediated activation of Akt to support T-cell survival.	AKT1 AKT2	4.55e-05	2	235	2	18042802
Pubmed	Cadmium, cobalt and lead cause stress response, cell cycle deregulation and increased steroid as well as xenobiotic metabolism in primary normal human bronchial epithelial cells which is coordinated by at least nine transcription factors.	AKR1C1 AKR1C2	4.55e-05	2	235	2	18654764
Cytoband	12q24.11	ACACB SSH1 MYO1H GPN3	2.44e-05	33	235	4	12q24.11
Cytoband	5q32	ARSI FBXO38 PCYOX1L ARHGEF37	1.73e-04	54	235	4	5q32
Cytoband	10p15-p14	AKR1C1 AKR1C2	3.86e-04	6	235	2	10p15-p14
Coexpression	GSE22033_UNTREATED_VS_MRL24_TREATED_MEF_DN	TSPOAP1 CFB NRP2 SYP CMKLR1 TBXAS1 ATN1 HAT1 MCOLN1 SNED1 DCP1A	1.73e-06	197	234	11	M7696
Coexpression	GSE19825_NAIVE_VS_IL2RAHIGH_DAY3_EFF_CD8_TCELL_UP	SERPINF1 PEG3 DUOX1 KCND2 SYP UTRN SNED1 CELF3 TENM1 TMEM108	1.36e-05	200	234	10	M4299
Coexpression	MANNO_MIDBRAIN_NEUROTYPES_HDA2	CSMD2 AKR1C1 AKR1C2 SYNPR PIK3CD ABCC8 LRRTM4 SYP CELF5 CHRNA6 NEDD4L NTSR1 CELF3 PRKACB CSMD1 LGI1	1.68e-05	513	234	16	M39069
Coexpression	GSE13522_WT_VS_IFNG_KO_SKIN_DN	PDE7A PEG3 GPR82 SLC25A37 CTPS2 FDXACB1 CELF5 NPHP3	1.93e-05	127	234	8	M1898
Coexpression	MANNO_MIDBRAIN_NEUROTYPES_HDA1	TSPOAP1 PEG3 CSMD2 AKR1C1 AKR1C2 PRDM8 TULP4 KCND2 LRRTM4 SYP CELF5 FAT4 NEDD4L NTSR1 CELF3 TENM1 CSMD1	2.21e-05	584	234	17	M39068
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HECW1 ABCA13 ADGRV1 LRP1B FAT4 MUC5B TEX11 GUCY2F TENM1 CSMD1	5.40e-08	184	235	10	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HECW1 ABCA13 ADGRV1 LRP1B FAT4 MUC5B TEX11 GUCY2F TENM1 CSMD1	5.40e-08	184	235	10	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HECW1 ABCA13 ADGRV1 LRP1B FAT4 MUC5B TEX11 GUCY2F TENM1 CSMD1	5.40e-08	184	235	10	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	3'-Parenchyma_lung-Epithelial-Epithelial_transtional-secretory\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SERPINF1 INSR AKR1C1 SLC25A37 CFB NRP2 PROM1 ADRA2A NEDD4L MUC5B	8.87e-08	194	235	10	dc531cf9089f2c956621d70d49a2b8219b4b45c1
ToppCell	Tracheal-NucSeq-Stromal-Fibroblastic-Fibro_adventitial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	SERPINF1 VIT EBF2 KCND2 FAT4 PREX2 SNED1 CELF2 ABCA6 TENM1	1.18e-07	200	235	10	0c25d56292b9e5fefa4521b72635449be1ffd6fe
ToppCell	5'-Parenchyma_lung-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(non-nasal)-Club_(non-nasal)_L.0.4.0.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SERPINF1 INSR AKR1C1 ADRA2A AFM LRRTM4 FYB2 MUC5B PDE8B	2.58e-07	166	235	9	9e98e6070055bfc780becee52d77830e06b6d854
ToppCell	BAL-Severe-Myeloid-cDC-cDC-cDC_4\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	MYO1A SERPINF1 DDX43 TBXAS1 MRC1 CHRNA6 LRRK1 CSMD1 PTPN20	2.85e-07	168	235	9	d60f7cd8269f373827f49c7785002cb38e4570a9
ToppCell	BAL-Severe-Myeloid-cDC-cDC-cDC_4\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	MYO1A SERPINF1 DDX43 TBXAS1 MRC1 CHRNA6 LRRK1 CSMD1 PTPN20	3.00e-07	169	235	9	ccd98f9005aa0a88bd49f153be4e7200cc3dd0ac
ToppCell	droplet-Thymus-nan-21m-Myeloid-B_cell\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IFNK MYADM PEG3 PLCG2 GNAZ CHST7 FGD2 KCTD14 RAI2	3.32e-07	171	235	9	8bed33f61f7d12a1ac4fba33f730d839f5ee7bef
ToppCell	droplet-Lung-immune-endo-depleted-3m-Myeloid-Interstitial_Macrophage\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	B3GALNT1 SERPINF1 MGMT ALMS1 C3AR1 MRC1 RALGAPA2 MCOLN1 NPHP3	4.87e-07	179	235	9	6eb84fe9691ad40127b2d1f1c672428333c8fab4
ToppCell	droplet-Lung-immune-endo-depleted-3m-Myeloid-lung_macrophage\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	B3GALNT1 SERPINF1 MGMT ALMS1 C3AR1 MRC1 RALGAPA2 MCOLN1 NPHP3	4.87e-07	179	235	9	2c3abd646d2c8992e8ff76a824eab5beba8ba4c6
ToppCell	Children_(3_yrs)-Immune-interstitial_macrophage_(C1Q_positive)-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	NRP2 ACSM5 C3AR1 CMKLR1 TBXAS1 MRC1 FGD2 LRRK1 ABCA6	6.42e-07	185	235	9	8207f9eff113eed429e961748c6b17d672a13b33
ToppCell	(2)_Fibroblasts-(20)_Fibro-1\|(2)_Fibroblasts / Cell class and subclass of bone marrow stroma cells in homeostatis	SERPINF1 ARSI CFB EBF2 PRDM8 ADAMTS15 SNED1 CELF2 CSMD1	6.72e-07	186	235	9	e93415b59dd89bc8a966dab0e0b65fe215933598
ToppCell	343B-Epithelial_cells-Epithelial-G_(Club-Clara_cells)\|343B / Donor, Lineage, Cell class and subclass (all cells)	SERPINF1 AKR1C1 AKR1C2 CFB PROM1 ADRA2A NEDD4L MUC5B PDE8B	7.68e-07	189	235	9	a8246acf31f02c85421268245afb651aa8788f14
ToppCell	343B-Epithelial_cells-Epithelial-G_(Club-Clara_cells)-\|343B / Donor, Lineage, Cell class and subclass (all cells)	SERPINF1 AKR1C1 AKR1C2 CFB PROM1 ADRA2A NEDD4L MUC5B PDE8B	7.68e-07	189	235	9	b06471b1bebb990d5146bddfb8002401c6b099a0
ToppCell	(7)_Epithelial_cells-(7)_Epithelial-G_(Club-Clara_cells)\|(7)_Epithelial_cells / Lung cell shreds - cell class (v4) and cell subclass (v4)	SERPINF1 AKR1C1 AKR1C2 CFB PROM1 PRDM8 ADRA2A MUC5B PDE8B	8.76e-07	192	235	9	c7c232545fad8ad327ab94bd0def8dc5daacd03d
ToppCell	LV-01._Fibroblast_I\|LV / Chamber and Cluster_Paper	SERPINF1 VIT AKR1C1 AKR1C2 EBF2 SNED1 CELF2 ABCA6 UGGT2	9.15e-07	193	235	9	dc17f3b9758936d428cf17f77a1ce6d4c479b165
ToppCell	3'-Parenchyma_lung-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(non-nasal)\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SERPINF1 INSR AKR1C1 SLC25A37 CFB NRP2 PROM1 NEDD4L MUC5B	9.55e-07	194	235	9	855d6acfcf323868ba98b213f06186ad4793d4ed
ToppCell	3'-Parenchyma_lung-Epithelial-Epithelial_transtional-secretory-club_cell\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SERPINF1 INSR AKR1C1 SLC25A37 CFB NRP2 PROM1 NEDD4L MUC5B	9.55e-07	194	235	9	29a7770bdbea6081a9ed64a997cd92a1cbf4af58
ToppCell	3'-Parenchyma_lung-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(non-nasal)-Club_(non-nasal)_L.0.4.1.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SERPINF1 INSR AKR1C1 SLC25A37 CFB NRP2 PROM1 NEDD4L MUC5B	9.55e-07	194	235	9	ca051088f880154ae2fd3f0ab3cef5a8dba8c371
ToppCell	RA-02._Fibroblast_II\|RA / Chamber and Cluster_Paper	SERPINF1 VIT AKR1C1 AKR1C2 EBF2 SNED1 CELF2 ABCA6 UGGT2	9.97e-07	195	235	9	6a02ebbeb3199447ddce64d92d8809436e040eba
ToppCell	LA-02._Fibroblast_II\|World / Chamber and Cluster_Paper	SERPINF1 VIT EBF2 PXDN KCND2 SNED1 CELF2 ABCA6 UGGT2	9.97e-07	195	235	9	a78b605b49acd8c9d68716266ca269dafcd910b9
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Immune\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	TMEM156 PIK3CD C3AR1 CMKLR1 TBXAS1 MRC1 FGD2 LRRK1 CELF2	9.97e-07	195	235	9	ce8215d503cad3a9bc7d5d2be4adb57408015593
ToppCell	Bronchial-NucSeq-Epithelial-Epi_airway_secretory\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	ARHGAP32 SPAM1 ABCA13 AKR1C1 AKR1C2 PROM1 NEDD4L MUC5B FAAH2	9.97e-07	195	235	9	e7230a849ea31e6eef9bc6f5468938499450582d
ToppCell	COVID-19-lung\|COVID-19 / Disease (COVID-19 only), tissue and cell type	NRP2 DUOX1 UTRN TBXAS1 MRC1 FGD2 ATP10A CELF2 MX1	1.18e-06	199	235	9	155b03b859157013e9142e9248551369127d9204
ToppCell	Tracheal-NucSeq-Epithelial-Epi_submucosal-gland\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	ARHGAP32 GALE ADGRV1 SLC25A37 PROM1 RASAL1 NEDD4L MUC5B RALGAPA2	1.23e-06	200	235	9	0eb9ad8c0373bcc62029ec21c590ed03aaacd039
ToppCell	PND03-Immune-Immune_Myeloid-Monocytic-Macrophage-IM-IM_prolif\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	HFE MCM4 C3AR1 TBXAS1 PPP1R21 MRC1 POLA1 CAPN3	2.12e-06	159	235	8	c0e55f25271f788c08fa4b95186501fc27b2ec39
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Degenerative_Proximal_Tubule_Epithelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	HECW1 CSMD2 SYNPR AFM LRRTM4 GDA VRTN CSMD1	3.05e-06	167	235	8	3edb0570e583bb527165bcd8a4c25a042054043b
ToppCell	RA-01._Fibroblast_I\|RA / Chamber and Cluster_Paper	SERPINF1 VIT AKR1C1 AKR1C2 ADAMTS15 CELF2 ABCA6 UGGT2	3.33e-06	169	235	8	6373562ab3b1765060212a6a53d6543e7e942e80
ToppCell	droplet-Thymus-nan-21m-Myeloid-professional_antigen_presenting_cell\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HFE MYADM SERPINF1 PLCG2 GNAZ CHST7 FGD2 KCTD14	3.48e-06	170	235	8	29deb285d5a82c0abcc108012ca42f4b4b4d9e19
ToppCell	PND10-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2-AF2_prolif\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MCM4 ARSI TANGO6 POLA1 EID2 BEND3 ULK3 HACL1	3.48e-06	170	235	8	8465c3069bbc08705d070927e712b6bc85ac7c5b
ToppCell	droplet-Thymus-nan-21m-Myeloid\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HFE MYADM SERPINF1 PLCG2 GNAZ CHST7 FGD2 KCTD14	3.48e-06	170	235	8	dc35d66a9a9fe6cdd7f4ec0fe7efa49d02f2b5b2
ToppCell	Thalamus-Neuronal-Excitatory\|Thalamus / BrainAtlas - Mouse McCarroll V32	ARHGAP32 HECW1 PIK3CD CELF5 NEDD4L SLITRK3 PPP4R4 CELF3	4.50e-06	176	235	8	d2bbf13d21fb7582d7e5f90cd61a4ebe1cfccd66
ToppCell	PND14-Immune-Immune_Myeloid-Megakaryocyte/Platelet\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	TSPOAP1 MGMT C3AR1 ARHGEF37 GNAZ SMOX TBXAS1 CAPN3	4.89e-06	178	235	8	cb91558469ae0748106fb0b6d702edb0ff21a884
ToppCell	PND14-Immune-Immune_Myeloid-Megakaryocyte/Platelet-Megakaryocyte/Platelet-Megakaryocyte/Platelet_mature\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	TSPOAP1 MGMT C3AR1 ARHGEF37 GNAZ SMOX TBXAS1 CAPN3	4.89e-06	178	235	8	63f5880a5b514e20ef2c07a6a9cb8df34e6cede5
ToppCell	PND14-Immune-Immune_Myeloid-Megakaryocyte/Platelet-Megakaryocyte/Platelet\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	TSPOAP1 MGMT C3AR1 ARHGEF37 GNAZ SMOX TBXAS1 CAPN3	4.89e-06	178	235	8	82c84f8b8a7e6a3d3be3351b348a37143279c100
ToppCell	LA-01._Fibroblast_I\|LA / Chamber and Cluster_Paper	SERPINF1 VIT AKR1C2 EBF2 SNED1 CELF2 ABCA6 UGGT2	5.09e-06	179	235	8	dcb6ec9ae72b13fe388b72dace2815293fafe8ee
ToppCell	Control-Stromal_mesenchymal-Matrix_Fibroblast-MatrixFB\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PDE3A ARSI LRRTM4 ADAMTS15 SNED1 ABCA6 ASPA TMEM108	5.31e-06	180	235	8	08ae0f5d95c45feba68ad99788f7af7ff4c979af
ToppCell	Control-Stromal_mesenchymal-Matrix_Fibroblast\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PDE3A ARSI LRRTM4 ADAMTS15 SNED1 ABCA6 ASPA TMEM108	5.31e-06	180	235	8	9b1de1b4711adbf9a423f4d2d08f3f4c78f1f8f4
ToppCell	Control-Stromal_mesenchymal-Matrix_Fibroblast-Diff_MatrixFB\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PDE3A PEG3 ARSI LRRTM4 SNED1 ABCA6 ASPA TMEM108	5.53e-06	181	235	8	9e7d0f1afb8d9bc5a209ddb5314df3a25a0274d9
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_C_(IT_L4_RORB)-Exc_L2-4_RORB_GRIK1\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	NRP2 KCND2 LRRTM4 UTRN PPP1R21 JCAD PPP4R4 ATRNL1	5.53e-06	181	235	8	57994ff4ecffb15653aee00644d9f887f5e3461d
ToppCell	Children_(3_yrs)-Epithelial-lung_goblet_cell\|Children_(3_yrs) / Lineage, Cell type, age group and donor	INSR AKR1C1 PROM1 FYB2 NEDD4L MUC5B FAAH2 PDE8B	5.76e-06	182	235	8	3f1a666fe27dd7529c114539ed5f6b8ca585c875
ToppCell	Primary_Motor_Cortex_(M1)-Non-neuronal-Endothelial_Myeloid-Micro-Microglia\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	TMEM156 ACSM5 C3AR1 CMKLR1 PLCG2 TBXAS1 MRC1 FGD2	6.75e-06	186	235	8	e41f14aee8cfbf76b8d0d4695a6170e2cd92aec8
ToppCell	Primary_Motor_Cortex_(M1)-Non-neuronal-Endothelial_Myeloid-Micro\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	TMEM156 ACSM5 C3AR1 CMKLR1 PLCG2 TBXAS1 MRC1 FGD2	6.75e-06	186	235	8	9dd31dc9af1704f35c74de726a6c27fa21e9a014
ToppCell	Primary_Motor_Cortex_(M1)-Non-neuronal-Endothelial_Myeloid-Micro-Microglia-Micro_L1-6_C1QC\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	TMEM156 ACSM5 C3AR1 CMKLR1 PLCG2 TBXAS1 MRC1 FGD2	6.75e-06	186	235	8	b3633cd4e360c5b45060c50b4f606d483e03a89a
ToppCell	LA-01._Fibroblast_I\|World / Chamber and Cluster_Paper	SERPINF1 VIT EBF2 PXDN KCND2 CELF2 ABCA6 UGGT2	7.02e-06	187	235	8	4ea486991f66c29728d127171a07b81404ec0b78
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ARHGAP32 HECW1 ITPR1 PRDM8 LRRTM4 LRRK1 CELF2 ATRNL1	7.02e-06	187	235	8	f18628ffc7ff7c762b8339ba8822cf0c3157f469
ToppCell	Substantia_nigra-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	PEG3 SYP GNAZ CHRNA6 SH2D5 ATP6V0D1 CELF3 PRKACB	7.30e-06	188	235	8	b73e8a40393c3f656e2fcfe395a761b1f985c254
ToppCell	COVID-19-lung-Secretory\|lung / Disease (COVID-19 only), tissue and cell type	INSR ADGRV1 AKR1C1 PROM1 FYB2 NEDD4L MUC5B FAAH2	7.59e-06	189	235	8	84d48e3ed25bebb8bb8074b3a2c5e2e88cff7f25
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	NRP2 CFAP54 ADAMTS15 MRC1 CMKLR2 SH2D3C RALGAPA2 CHST8	7.89e-06	190	235	8	876bd2eb9ed2624cb23bdcf6b989e4fa34d099e3
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Endothelial-lymphatic_endothelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	NRP2 CFAP54 ADAMTS15 MRC1 CMKLR2 SH2D3C RALGAPA2 CHST8	7.89e-06	190	235	8	09a8855901c3c9332dbaab3e40166485b696d0f1
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Macrophage_Dendritic-M2_Macrophage\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PIK3CD C3AR1 CMKLR1 TBXAS1 MRC1 FGD2 LRRK1 CELF2	7.89e-06	190	235	8	788ff9d8888d2dd25b7e1d7e0e5d57751ce86f19
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex-lymphatic_endothelial_cell_of_renal_cortex\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	NRP2 CFAP54 ADAMTS15 MRC1 CMKLR2 SH2D3C RALGAPA2 CHST8	7.89e-06	190	235	8	be9f36127028f52ca5fc1b32ba15a6c26aad69ac
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Macrophage_Dendritic\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PIK3CD C3AR1 CMKLR1 TBXAS1 MRC1 FGD2 LRRK1 CELF2	8.20e-06	191	235	8	baa70781633a3fe5bf987f9d8dff3884f5167e7f
ToppCell	LA\|World / Chamber and Cluster_Paper	SERPINF1 VIT LRP1B EBF2 PXDN KCND2 ABCA6 PDE8B	8.85e-06	193	235	8	d4bf89437216baf489ea0239136dcedf3b6714af
ToppCell	RV-02._Fibroblast_II\|RV / Chamber and Cluster_Paper	SERPINF1 VIT AKR1C1 EBF2 SNED1 CELF2 ABCA6 UGGT2	9.18e-06	194	235	8	11c79a8c56ece42713b04b321982e41e239f07a5
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid-Macrophage_Dendritic-M2_Macrophage\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	NRP2 PIK3CD C3AR1 CMKLR1 TBXAS1 MRC1 FGD2 LRRK1	9.18e-06	194	235	8	1dce6d4b6ac41f80677e3e4c335a4f383bd76f85
ToppCell	BAL-Control-Myeloid-cDC-cDC-cDC_3\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	SERPINF1 GPR82 TMEM156 RASAL1 CHRNA6 LRRK1 ABCA6 P3H2	9.18e-06	194	235	8	e56c6e5c9b7d287ae94566b561e21cec2055f83d
ToppCell	LV-02._Fibroblast_II\|LV / Chamber and Cluster_Paper	SERPINF1 VIT AKR1C1 EBF2 SNED1 CELF2 ABCA6 UGGT2	9.18e-06	194	235	8	014d2feb5db2a6a35ef759761a41e466e108c3c1
ToppCell	Smart-seq2-spleen_(Smart-seq2)-myeloid-myeloid_granulocytic\|spleen_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	ABCA13 ADGRV1 CSMD2 LRP1B SLC25A37 ABCC8 CSMD1 LGI1	9.53e-06	195	235	8	19853c654ac64b3ae3bc99841c6cb29c8aaba85c
ToppCell	BAL-Control-Myeloid-cDC-cDC-cDC_3\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	SERPINF1 GPR82 TMEM156 RASAL1 CHRNA6 LRRK1 ABCA6 P3H2	9.53e-06	195	235	8	85fee07d71c0393ea42bcf1130566dff4a62f507
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PIK3CD C3AR1 CMKLR1 TBXAS1 MRC1 FGD2 LRRK1 CELF2	9.53e-06	195	235	8	09df40ff9b493170861b3f6e57a942a834655b5c
ToppCell	Smart-seq2-spleen_(Smart-seq2)-myeloid-myeloid_granulocytic-neutrophil\|spleen_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	ABCA13 ADGRV1 CSMD2 LRP1B SLC25A37 ABCC8 CSMD1 LGI1	9.53e-06	195	235	8	d3755929ebbbf5e3afde44281e9056ddb614a291
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid-Macrophage_Dendritic\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PIK3CD C3AR1 CMKLR1 TBXAS1 MRC1 FGD2 LRRK1 CELF2	9.53e-06	195	235	8	34a9462f4e843f3065cc58c17ad71c1b5b836ae1
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PIK3CD C3AR1 CMKLR1 TBXAS1 MRC1 FGD2 LRRK1 CELF2	9.90e-06	196	235	8	4370473693d2dd4a8c451a4c477eb79baa33ae12
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-1M-Neuronal-midbrain/hindbrain_cells\|Organoid-1M / Sample Type, Dataset, Time_group, and Cell type.	AKR1C1 AKR1C2 EBF2 DUOX1 SYP SH2D3C CHST8 CELF3	1.03e-05	197	235	8	c7078f6fcf27319ba8c5ebe700bcae7f1e7e39c1
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Macrophage_Dendritic\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PIK3CD C3AR1 CMKLR1 TBXAS1 MRC1 FGD2 LRRK1 CELF2	1.03e-05	197	235	8	d95565652ca318a2298d6918d54ba6367e9560f4
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PIK3CD C3AR1 CMKLR1 TBXAS1 MRC1 FGD2 LRRK1 CELF2	1.07e-05	198	235	8	96883ad8e189a46ed5b7eaafc0543e53682d26ed
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ARHGAP32 HECW1 PEG3 ITPR1 SYP CELF2 ATRNL1 CSMD1	1.07e-05	198	235	8	8ab40fae14fe02e39bc8c8da187a5cd60c787643
ToppCell	Bronchus_Control_(B.)-Stromal-TX-Mesothelial-1\|Bronchus_Control_(B.) / Sample group, Lineage and Cell type	PEG3 CMKLR2 USP28 ZNF596 PREX2 ASPA TENM1 POLDIP2	1.07e-05	198	235	8	9b1a58fcf818f9c4ae57bbe99655f0a64fe87df7
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	HECW1 PEG3 ITPR1 KCND2 SYP CELF2 ATRNL1 CSMD1	1.07e-05	198	235	8	4ca5ff320905ab4ff60ed90a5522227c782142a6
ToppCell	proximal-Epithelial-Mucous-3\|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	SERPINF1 INSR AKR1C1 AKR1C2 CFB PROM1 ADRA2A MUC5B	1.11e-05	199	235	8	baac580484124b7c36717b607adcf2cb446e631d
ToppCell	proximal-Epithelial-Mucous\|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	SERPINF1 INSR AKR1C1 AKR1C2 CFB PROM1 ADRA2A MUC5B	1.11e-05	199	235	8	15ba36fa6ad73d0e959e42f18d7acbc14e310dc9
ToppCell	proximal-3-Epithelial-Mucous\|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	SERPINF1 INSR AKR1C1 AKR1C2 CFB PROM1 ADRA2A MUC5B	1.11e-05	199	235	8	3018378860de084662be0cc46fce421db3bb9ec9
ToppCell	Tracheal-NucSeq-Epithelial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	ARHGAP32 GALE ADGRV1 PROM1 NEDD4L MUC5B RALGAPA2 FAAH2	1.15e-05	200	235	8	d3af0a706baf66e3f32e67b17dcfc31e5b32ce0e
ToppCell	Macroglial-Polydendrocytes\|Macroglial / cells hierarchy compared to all cells using T-Statistic	HECW1 CSMD2 PXDN KCND2 LRRTM4 ATRNL1 TENM1 CSMD1	1.15e-05	200	235	8	961858738ce35db8760c8c2e136f8369bc444ccf
ToppCell	Parenchymal-10x5prime-Stromal-Peri/Epineurial_\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	PDE3A SERPINF1 VIT EBF2 NPFFR2 PRDM8 SNED1 PTPN20	1.15e-05	200	235	8	4c3c11dd5e71ebc3d62264eeaeb71a850b149779
ToppCell	Tracheal-NucSeq-Stromal-Fibroblastic-Fibro_peribronchial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	HECW1 LRRTM4 FAT4 PREX2 CELF2 ABCA6 ATRNL1 TENM1	1.15e-05	200	235	8	58b38f9a484ee94191091a0659ed62ebed2d4a14
ToppCell	Macroglial-Polydendrocytes-PDGFRA-\|Macroglial / cells hierarchy compared to all cells using T-Statistic	HECW1 CSMD2 PXDN KCND2 LRRTM4 ATRNL1 TENM1 CSMD1	1.15e-05	200	235	8	f17b5a54e8f9eba9dcd0808ba4e8d275ac41bce2
ToppCell	Macroglial-Polydendrocytes-PDGFRA--\|Macroglial / cells hierarchy compared to all cells using T-Statistic	HECW1 CSMD2 PXDN KCND2 LRRTM4 ATRNL1 TENM1 CSMD1	1.15e-05	200	235	8	cc3409518f8b436ea92deb955e81114b3f410ff7
ToppCell	Hematolymphoid\|World / cells hierarchy compared to all cells using T-Statistic	TMEM156 ACSM5 C3AR1 CMKLR1 PLCG2 TBXAS1 MRC1 FGD2	1.15e-05	200	235	8	354bed3bfad1fab0c0c7f26925f8d91b80c6e0c7
ToppCell	Macroglial-Polydendrocytes-PDGFRA\|Macroglial / cells hierarchy compared to all cells using T-Statistic	HECW1 CSMD2 PXDN KCND2 LRRTM4 ATRNL1 TENM1 CSMD1	1.15e-05	200	235	8	c24a3099e3d96d8b72f6d05286bb355d661a0377
ToppCell	Macroglial-Polydendrocytes-PDGFRA---\|Macroglial / cells hierarchy compared to all cells using T-Statistic	HECW1 CSMD2 PXDN KCND2 LRRTM4 ATRNL1 TENM1 CSMD1	1.15e-05	200	235	8	4fc3de4bff7ed2bf40b38462c4b4e9b87af6a4ca
ToppCell	Macroglial-Polydendrocytes-PDGFRA----L1-6\|Macroglial / cells hierarchy compared to all cells using T-Statistic	HECW1 CSMD2 PXDN KCND2 LRRTM4 ATRNL1 TENM1 CSMD1	1.15e-05	200	235	8	310cd53db1c137f6af74e6ae682221d7ac27310c
ToppCell	COVID-19_Mild\|World / 5 Neutrophil clusters in COVID-19 patients	HECW1 TSPOAP1 ADGRV1 NUP58 NSD3 TENT4B CSMD1	1.65e-05	152	235	7	2ff0980dfd8d430cca14649151d856edef115720
ToppCell	PND03-Immune-Immune_Myeloid-DC-cDC1-cDC1_prolif\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	HFE ACACB SERPINF1 GPR82 TBXAS1 HAT1 KCTD14	1.95e-05	156	235	7	af47a4b17342bdb3cb62d7e2d52a81168e588629
ToppCell	Control-B_naive-12\|Control / disease group and sub_cluster of B and Plasma cells(res = 0.5)	PCYOX1L BTD WDR35 CMKLR1 TANGO6 PPP1R21 SEC22A	2.12e-05	158	235	7	41318f864770370ce77ed3fa4a84f76c0c22c482
ToppCell	3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.2.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ABCA13 INSR CFB FYB2 MYO1H MUC5B RAD51AP2	2.21e-05	159	235	7	60b1f4dce2ce0911160fda17f137c064da31e2eb
ToppCell	facs-Trachea-3m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l32-30\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CLDN17 RASAL1 DSC1 SLITRK3 CLDN6 CLDN9 CSMD1	2.69e-05	164	235	7	3caf4cdaa0164907893fea61e251fd8b5fa926e4
ToppCell	droplet-Lung-nan-3m-Myeloid-myeloid_dendritic_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HFE GPR82 ARSI PHKG1 FGD2 CLDN9 KCTD14	2.69e-05	164	235	7	a67dd181eba275c191f4d0cab13df30eaa3ad913
ToppCell	5'-Parenchyma_lung-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(non-nasal)-Club_(non-nasal)_L.0.4.1.3\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SERPINF1 INSR AKR1C1 CFB SMOX MUC5B PTPN20	3.02e-05	167	235	7	8fede587572d465cb63f7828141a574185bbb819
ToppCell	facs-Mammary_Gland-Mammary_Gland-21m-Mesenchymal-stromal_cell\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	B3GALNT1 SERPINF1 ARSI CFB EBF2 PRDM8 CMKLR2	3.26e-05	169	235	7	5f18e3f40a5b1b167903f37516ec8181e889c7c5
ToppCell	facs-Mammary_Gland-Mammary_Gland-21m-Mesenchymal-stromal_cell\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	B3GALNT1 SERPINF1 ARSI CFB EBF2 PRDM8 CMKLR2	3.26e-05	169	235	7	8bfa2d3bb541d02f55d7c95b8fd156c8403befca
ToppCell	COVID-19-Heart-Adipocyte\|Heart / Disease (COVID-19 only), tissue and cell type	AKR1C1 PXDN KCND2 DGAT2 ACSM5 SHMT1 ATP10A	3.26e-05	169	235	7	bd39f85b48207955f80ca120a11e15a0124117b9
ToppCell	facs-Mammary_Gland-Mammary_Gland-21m-Mesenchymal\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	B3GALNT1 SERPINF1 ARSI CFB EBF2 PRDM8 CMKLR2	3.26e-05	169	235	7	bb43abad2c049b7f4d307737347290e01b3339a3
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_D_(IT_RORB_THEMIS_LINC00507)_6-Exc_L5-6_THEMIS_TMEM233\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	VIT PXDN RASAL1 PPP4R4 CHST8 SNED1 GDA	3.52e-05	171	235	7	fdd96c6fe850bd10e1e0d0f18c4401f8348b7d2c
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid-Monocytic-Monocyte-derived_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	MYO1A PIK3CD C3AR1 TBXAS1 FGD2 LRRK1 CELF2	3.65e-05	172	235	7	f6b4754a7e4b3e38030316a0ae00d932bfa87e41
ToppCell	droplet-Thymus-nan-21m-Lymphocytic-B_cell\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYADM CUL7 CFB CHST7 KCTD14 RAI2 MX1	3.79e-05	173	235	7	0a0cd40bb5f61431fe34758626c8a63ec610a8a5
ToppCell	Adult-Epithelial-lung_goblet_cell-D231\|Adult / Lineage, Cell type, age group and donor	INSR TULP1 PROM1 PRDM8 FYB2 MUC5B PDE8B	3.93e-05	174	235	7	7d2f802f493f19a068e097b2909a9000e2160266
ToppCell	droplet-Thymus-nan-24m-Myeloid-Macrophage\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYADM CFB C3AR1 CMKLR1 TBXAS1 MRC1 GDA	3.93e-05	174	235	7	44c21521991ad4789783d73d5aa4993a22876886
Drug	Chlorambucil [305-03-3]; Down 200; 13.2uM; MCF7; HT_HG-U133A	RALGAPA1 HFE SPAM1 SRCAP ITPR1 ALMS1 AKT2 EXOC7 RASAL1 NEDD4L CHST8 OVGP1	8.55e-07	195	233	12	4345_DN
Drug	Cloperastine hydrochloride [14984-68-0]; Down 200; 11uM; PC3; HT_HG-U133A	B3GALNT1 ITPR1 FBXO38 ALMS1 BTD TAF1 EXOC7 CMKLR2 TRIM33 PPP2R3A EIF5B	5.70e-06	195	233	11	3710_DN
Drug	Cephalothin sodium salt [58-71-9]; Up 200; 9.6uM; PC3; HT_HG-U133A	HFE SPAM1 INSR NRP2 CHRNA6 FAT4 ATN1 MUC5B PPP4R4 CELF2 KCTD14	5.98e-06	196	233	11	4482_UP
Drug	Paromomycin sulfate [1263-89-4]; Down 200; 5.6uM; MCF7; HT_HG-U133A	RALGAPA1 HFE EMC1 NCBP1 NSD3 ITPR1 SETDB1 ZFYVE9 HCFC2 PREX2 PDE8B	6.59e-06	198	233	11	3356_DN
Drug	5255229; Down 200; 13uM; MCF7; HT_HG-U133A_EA	HFE UPF3A ITPR1 TEX264 BTD TAF1 GNAZ ZNHIT2 PTGES2 PPP2R3A METTL25B	6.59e-06	198	233	11	949_DN
Drug	Roflumilast	PDE3A PDE7A AKT1 PDE8B	1.77e-05	16	233	4	ctd:C424423
Drug	Alprostadil [745-65-3]; Up 200; 11.2uM; PC3; HT_HG-U133A	AADAC INSR NRP2 ITPR1 SMOX CHRNA6 ATN1 DSC1 PPP4R4 MX1	2.65e-05	189	233	10	4099_UP
Drug	Proglumide [6620-60-6]; Up 200; 12uM; MCF7; HT_HG-U133A	GALE MCM4 SRCAP ZFYVE9 ABCC8 AKT2 JCAD ATN1 MCOLN1 CELF3	2.90e-05	191	233	10	3861_UP
Drug	Haloperidol [52-86-8]; Down 200; 10.6uM; MCF7; HT_HG-U133A	RALGAPA1 HFE SERPINF1 MCM4 NSD3 ALMS1 BTD UTRN CMKLR2 PREX2	3.17e-05	193	233	10	5273_DN
Drug	Hydroxytacrine maleate (R,S) [118909-22-1]; Down 200; 12.2uM; HL60; HT_HG-U133A	EMC1 ACACB SRCAP NSD3 BTD TAF1 EXOC7 TAF1B OVGP1 PRKACA	3.31e-05	194	233	10	2430_DN
Drug	Glipizide [29094-61-9]; Up 200; 9uM; MCF7; HT_HG-U133A	SPAM1 ACACB CUL7 SRCAP ZNF614 ATN1 ATP10A PPP4R4 PDE8B RAI2	3.46e-05	195	233	10	4991_UP
Drug	Ergocryptine-alpha [511-09-1]; Up 200; 7uM; PC3; HT_HG-U133A	HFE INSR SRCAP AKT2 ATN1 ATP10A CHST8 SNED1 CELF3 ASPA	3.61e-05	196	233	10	3817_UP
Drug	Cefaclor [70356-03-5]; Down 200; 10.4uM; MCF7; HT_HG-U133A	HFE EMC1 NCBP1 CUL7 SRCAP AKT2 GNAZ EXOC7 RASAL1 IPO8	3.61e-05	196	233	10	2843_DN
Drug	Dosulepin hydrochloride [897-15-4]; Up 200; 12uM; MCF7; HT_HG-U133A	HFE HECW1 ZFYVE9 PIK3CD CLDN17 GNAZ RASAL1 PPP4R4 PPP2R3A PRKACA	3.77e-05	197	233	10	2864_UP
Drug	Gabapentin [60142-96-3]; Up 200; 23.4uM; PC3; HT_HG-U133A	RALGAPA1 HECW1 TSPOAP1 INSR NRP2 ZFYVE9 SMOX LRRK1 CATSPER2 PDE8B	3.94e-05	198	233	10	5875_UP
Drug	cis-4,7,10,13,16,19-Docosahexaenoic acid ethyl ester; Down 200; 100uM; PC3; HG-U133A	RALGAPA1 HFE EMC1 SRCAP PIK3CD PLCG2 CHST7 ZNF614 NEDD4L PDE8B	3.94e-05	198	233	10	664_DN
Drug	Benzocaine [94-09-7]; Down 200; 24.2uM; HL60; HT_HG-U133A	SPAM1 EMC1 SRCAP RASAL1 PTGES2 NTSR1 MCOLN1 PREX2 OVGP1 MX1	4.11e-05	199	233	10	2167_DN
Drug	Acebutolol hydrochloride [34381-68-5]; Down 200; 10.8uM; MCF7; HT_HG-U133A	EMC1 NCBP1 SRCAP NSD3 BTD GNAZ EXOC7 UTRN CHST10 PPP2R3A	4.11e-05	199	233	10	1493_DN
Disease	Prostatic Neoplasms	ATR SERPINF1 LRP1B ITPR1 SETDB1 PIK3CD BRPF1 AKT1 TBXAS1 USP28 XPO1 SIRT1 CLDN9 CELF2 PRKACB INTS4 ZBED1	6.15e-06	616	226	17	C0033578
Disease	Malignant neoplasm of prostate	ATR SERPINF1 LRP1B ITPR1 SETDB1 PIK3CD BRPF1 AKT1 TBXAS1 USP28 XPO1 SIRT1 CLDN9 CELF2 PRKACB INTS4 ZBED1	6.15e-06	616	226	17	C0376358
Disease	type 2 diabetes mellitus (implicated_via_orthology)	SERPINF1 INSR ALMS1 PIK3CD AKT1 AKT2 SIRT1	1.70e-05	105	226	7	DOID:9352 (implicated_via_orthology)
Disease	alcohol use disorder (implicated_via_orthology)	SSH1 PIK3CD AKT1 AKT2 CHRNA6 SHMT1 SIRT1 PRKACA PRKACB	2.10e-05	195	226	9	DOID:1574 (implicated_via_orthology)
Disease	Colorectal Carcinoma	ABCA13 SF3A1 PEG3 PROM1 ABCC8 ADAMTS15 AKT1 ANAPC4 RBP3 HAT1 PREX2 CHST8 OVGP1 ABCA6 TENM1 VRTN DSEL	3.27e-05	702	226	17	C0009402
Disease	response to carboplatin, response to antineoplastic agent	PLCG2 ULK3 CSMD1	5.11e-05	10	226	3	GO_0097327, GO_0097328
Disease	fatty liver disease (implicated_via_orthology)	ACACB INSR DGAT2 SIRT1	8.96e-05	31	226	4	DOID:9452 (implicated_via_orthology)
Disease	N-acetyl-2-aminooctanoate measurement	ALMS1 BTD HACL1	9.27e-05	12	226	3	EFO_0800567
Disease	beta-amyloid 1-42 measurement, cerebrospinal fluid biomarker measurement	HECW1 FAT4 LGI1	1.52e-04	14	226	3	EFO_0004670, EFO_0006794
Disease	Neoplasms, Hormone-Dependent	AKR1C1 AKR1C2	1.74e-04	3	226	2	C0027661
Disease	Primary pigmented nodular adrenocortical disease	PDE8B PRKACA	3.47e-04	4	226	2	C4304832
Disease	primary pigmented nodular adrenocortical disease (is_implicated_in)	PDE8B PRKACA	3.47e-04	4	226	2	DOID:0060280 (is_implicated_in)
Disease	retinoblastoma (is_implicated_in)	SERPINF1 MGMT	3.47e-04	4	226	2	DOID:768 (is_implicated_in)
Disease	prostate adenocarcinoma (is_implicated_in)	INSR AKT1 AKT2	4.59e-04	20	226	3	DOID:2526 (is_implicated_in)
Disease	2-hydroxyoctanoate measurement	ALMS1 HACL1	5.75e-04	5	226	2	EFO_0800192
Disease	Hermaphroditism	AKR1C1 AKR1C2	5.75e-04	5	226	2	C0019269
Disease	Ambiguous Genitalia	AKR1C1 AKR1C2	5.75e-04	5	226	2	C0266362
Disease	Pseudohermaphroditism	AKR1C1 AKR1C2	5.75e-04	5	226	2	C0033804
Disease	Intersex Conditions	AKR1C1 AKR1C2	5.75e-04	5	226	2	C2930618
Disease	Sex Differentiation Disorders	AKR1C1 AKR1C2	5.75e-04	5	226	2	C2930619
Disease	phospholipids:total lipids ratio, high density lipoprotein cholesterol measurement	INSR TULP1 DGAT2 AKT1 MYO1H CAPN3 NPHP3 ATP6V0D1 ABCA6	6.42e-04	307	226	9	EFO_0004612, EFO_0020946
Disease	Intrahepatic Cholangiocarcinoma	PEG3 PRKACA PRKACB	7.97e-04	24	226	3	C0345905
Disease	Extrahepatic Cholangiocarcinoma	PEG3 PRKACA PRKACB	7.97e-04	24	226	3	C3805278
Disease	gene methylation measurement	MGMT ABCA6	8.58e-04	6	226	2	EFO_0006959
Disease	progression free survival, methylcobalamin deficiency type cblE, ovarian carcinoma, response to cisplatin	KCTD14 INTS4	8.58e-04	6	226	2	EFO_0001075, EFO_0004920, GO_0072718, MONDO_0009354
Disease	Adenocarcinoma of large intestine	PHKG1 AKT1 AKT2 TAF1 RAD21	8.75e-04	96	226	5	C1319315
Disease	Cholangiocarcinoma	PEG3 PRKACA PRKACB	1.01e-03	26	226	3	C0206698
Disease	diabetes mellitus (implicated_via_orthology)	INSR PROM1 SIRT1	1.01e-03	26	226	3	DOID:9351 (implicated_via_orthology)
Disease	Agouti-related protein measurement	TANGO6 ATP6V0D1 ABCA6	1.13e-03	27	226	3	EFO_0008016
Disease	Insulin Resistance	ACACB INSR MRC1 SIRT1	1.17e-03	60	226	4	C0021655
Disease	Insulin Sensitivity	ACACB INSR MRC1 SIRT1	1.17e-03	60	226	4	C0920563
Disease	Disorders of Sex Development	AKR1C1 AKR1C2	1.20e-03	7	226	2	C0036875
Disease	Neoplasm of uncertain or unknown behavior of ovary	ATR AKT1 AKT2	1.40e-03	29	226	3	C0496920
Disease	peptide measurement	SPAM1 ABCA13 CHAT SH2D3C CSMD1	1.54e-03	109	226	5	EFO_0010520
Disease	Ovarian Carcinoma	ATR AKT1 AKT2	1.55e-03	30	226	3	C0029925
Disease	non-alcoholic fatty liver disease (biomarker_via_orthology)	ACACB INSR DGAT2 SIRT1	1.57e-03	65	226	4	DOID:0080208 (biomarker_via_orthology)
Disease	Familial hyperinsulinism	INSR ABCC8	1.59e-03	8	226	2	cv:C3888018
Disease	Familial partial lipodystrophy	ADRA2A AKT2	1.59e-03	8	226	2	C0271694
Disease	PARTINGTON X-LINKED MENTAL RETARDATION SYNDROME	BRWD3 POLA1	1.59e-03	8	226	2	C0796250
Disease	2-aminooctanoate measurement	ALMS1 HACL1	1.59e-03	8	226	2	EFO_0800349
Disease	Uveitis	SERPINF1 RBP3	2.03e-03	9	226	2	C0042164
Disease	response to high fat food intake, triglyceride change measurement	BEND3 PTPN20	2.03e-03	9	226	2	EFO_0007681, EFO_0007684
Disease	type 2 diabetes mellitus (is_implicated_in)	HFE SERPINF1 INSR ADRA2A ABCC8 AKT2	2.10e-03	171	226	6	DOID:9352 (is_implicated_in)
Disease	colorectal cancer (is_implicated_in)	HFE LRP1B PIK3CD AKT1 XPO1	2.44e-03	121	226	5	DOID:9256 (is_implicated_in)
Disease	Ceroid lipofuscinosis, neuronal 1, infantile	SYP SIRT1	2.52e-03	10	226	2	C2931673
Disease	2-ketocaprylate measurement	ALMS1 HACL1	2.52e-03	10	226	2	EFO_0800110
Disease	colon cancer (is_implicated_in)	ATR LRP1B AKT1	2.63e-03	36	226	3	DOID:219 (is_implicated_in)
Disease	endometrial cancer (is_implicated_in)	PIK3CD AKT2 RAD21	2.63e-03	36	226	3	DOID:1380 (is_implicated_in)
Disease	response to radiation, prostate carcinoma, erectile dysfunction	LRP1B CMKLR1 DDX53	2.84e-03	37	226	3	EFO_0001663, EFO_0004234, GO_0009314
Disease	gastric adenocarcinoma (is_implicated_in)	ABCA13 XPO1	3.07e-03	11	226	2	DOID:3717 (is_implicated_in)
Disease	X-18913 measurement	BTD HACL1	3.07e-03	11	226	2	EFO_0800795
Disease	Ashkenazi Jewish disorders	MCOLN1 ASPA	3.07e-03	11	226	2	cv:CN118946
Disease	total cholesterol measurement, high density lipoprotein cholesterol measurement	PDE3A TULP1 DGAT2 AKT1 TANGO6 MYO1H ATP6V0D1 HACL1	3.10e-03	315	226	8	EFO_0004574, EFO_0004612
Disease	Mental Depression	CHAT CSMD2 ADRA2A AKT1 CMKLR1 CHRNA6 LGI1	3.57e-03	254	226	7	C0011570
Disease	liver disease (is_implicated_in)	HFE MX1	3.66e-03	12	226	2	DOID:409 (is_implicated_in)
Disease	uterine fibroid	ITPR1 EBF2 RIC8A PGBD2 TEX11 CSMD1	4.44e-03	199	226	6	EFO_0000731
Disease	left ventricular systolic function measurement	LRP1B PXDN NEDD4L	4.66e-03	44	226	3	EFO_0008206
Disease	high grade glioma (implicated_via_orthology)	INSR PIK3CD AKT2	4.66e-03	44	226	3	DOID:3070 (implicated_via_orthology)
Disease	DNA methylation	SPAM1 ABCA13 LRP1B ALMS1 LRRTM4 CMKLR1 JCAD FAT4 ZNF596 CELF2 CSMD1 PTPN20	4.93e-03	656	226	12	GO_0006306
Disease	middle cerebral artery infarction (implicated_via_orthology)	SERPINF1 ABCC8 SIRT1	4.96e-03	45	226	3	DOID:3525 (implicated_via_orthology)
Disease	Pneumoconiosis	ATR OVGP1	5.00e-03	14	226	2	C0032273
Disease	Bagassosis	ATR OVGP1	5.00e-03	14	226	2	C0004681
Disease	parental longevity	PDE3A LRP1B NPFFR2 ABCC8 ANAPC4 TANGO6 JCAD BEND3 HACL1 CSMD1	5.02e-03	494	226	10	EFO_0007796
Disease	eye color	ARHGAP32 TULP4 AFM CSMD1	5.12e-03	90	226	4	EFO_0003949
Disease	Adenocarcinoma of lung (disorder)	ATR AKT1 SHMT1 TRIM33 GUCY2F HSD17B10	5.24e-03	206	226	6	C0152013
Disease	obesity (biomarker_via_orthology)	PDE3A ACACB SERPINF1 AKT2 SIRT1	5.59e-03	147	226	5	DOID:9970 (biomarker_via_orthology)
Disease	N-acetylmethionine measurement	ITPR1 ALMS1	5.74e-03	15	226	2	EFO_0021427
Disease	photoreceptor cell layer thickness measurement	RALGAPA1 TULP1 DUOX1 PTGES2 RBP3	5.75e-03	148	226	5	EFO_0803370
Disease	autism	SYNPR ADCK5 TRIM33	5.95e-03	48	226	3	EFO_0003758
Disease	Disorder of eye	ADGRV1 TULP1 PROM1 ALMS1 RBP3 NPHP3	6.01e-03	212	226	6	C0015397
Disease	diabetic nephropathy	CHAT NRP2 ITPR1 TBXAS1 SH2D3C	6.08e-03	150	226	5	EFO_0000401
Disease	age at menarche	B3GALNT1 IQANK1 RBM12B LRP1B ALMS1 ANAPC4 MYO1H FAAH2 ATRNL1 TMEM108 CSMD1	6.39e-03	594	226	11	EFO_0004703
Disease	urinary uromodulin measurement	SLC25A37 FBXO38 LRRTM4 TAF1B	6.43e-03	96	226	4	EFO_0005663
Disease	obesity (implicated_via_orthology)	TULP1 ITPR1 ALMS1 FAT4 CAPN3 SIRT1	6.43e-03	215	226	6	DOID:9970 (implicated_via_orthology)
Disease	hypothyroidism	HFE INSR SLC25A37 TULP1 FGD2 PDE8B RSBN1L	6.50e-03	284	226	7	EFO_0004705
Disease	neutrophil collagenase measurement	ABCA13 CFB	6.53e-03	16	226	2	EFO_0008248
Disease	congenital myasthenic syndrome (implicated_via_orthology)	CHAT CHRNA6	6.53e-03	16	226	2	DOID:3635 (implicated_via_orthology)
Disease	response to methotrexate	AKR1C1 AKR1C2	6.53e-03	16	226	2	GO_0031427
Disease	Monogenic diabetes	INSR ABCC8	6.53e-03	16	226	2	C3888631
Disease	Fibrosis	ADRA2A AKT1 SIRT1	6.67e-03	50	226	3	C0016059
Disease	diabetic retinopathy (is_implicated_in)	HFE SERPINF1 CFB	6.67e-03	50	226	3	DOID:8947 (is_implicated_in)
Disease	Cirrhosis	ADRA2A AKT1 SIRT1	6.67e-03	50	226	3	C1623038
Disease	Depressive disorder	CHAT CSMD2 ADRA2A AKT1 CMKLR1 CHRNA6 LGI1	7.12e-03	289	226	7	C0011581
Disease	Parkinson's disease (implicated_via_orthology)	INSR AKT1 AKT2 LRRK1 SIRT1	7.34e-03	157	226	5	DOID:14330 (implicated_via_orthology)
Disease	unipolar depression, response to selective serotonin reuptake inhibitor, mood disorder	TAF1B DSEL	7.36e-03	17	226	2	EFO_0003761, EFO_0004247, EFO_0005658
Disease	1-Methylhistidine measurement	ALMS1 KCND2	7.36e-03	17	226	2	EFO_0021543
Disease	lateral occipital cortex volume measurement	MGMT UTRN	7.36e-03	17	226	2	EFO_0010311
Disease	Familial Progressive Myoclonic Epilepsy	PRDM8 ATN1	7.36e-03	17	226	2	C0751777
Disease	Atypical Inclusion-Body Disease	PRDM8 ATN1	7.36e-03	17	226	2	C0751776
Disease	Myoclonic Epilepsies, Progressive	PRDM8 ATN1	7.36e-03	17	226	2	C0751778
Disease	Biotin-Responsive Encephalopathy	PRDM8 ATN1	7.36e-03	17	226	2	C0751780
Disease	May-White Syndrome	PRDM8 ATN1	7.36e-03	17	226	2	C0751782
Disease	Dentatorubral-Pallidoluysian Atrophy	PRDM8 ATN1	7.36e-03	17	226	2	C0751781
Disease	ischemia (implicated_via_orthology)	LONP1 AKT2	7.36e-03	17	226	2	DOID:326 (implicated_via_orthology)
Disease	methylcobalamin deficiency type cblE, overall survival, ovarian carcinoma, response to cisplatin	KCTD14 INTS4	7.36e-03	17	226	2	EFO_0000638, EFO_0001075, GO_0072718, MONDO_0009354

Protein segments in the cluster

Peptide	Gene	Start	Entry
IDIAFAYPFRLHQVT	SYNPR	41	Q8TBG9
RLPFYNQDHEKLFEL	AKT1	346	P31749
GRLPFYNQDHERLFE	AKT2	346	P31751
FIYHLPQEFGDQDIL	CELF2	426	O95319
NIFIYHLPQEFTDSE	CELF3	381	Q5SZQ8
VHLIYFLQRQDDPES	CFAP54	506	Q96N23
FLTEHFNEAPDLYNR	ANAPC4	451	Q9UJX5
RQDLEYHVFFSDLPN	CATSPER2	271	Q96P56
RIHLIFNDFDVEPQF	CSMD1	621	Q96PZ7
VFNIFNLEPGYDFLH	CSMD2	1486	Q7Z408
LNFSTEPNHDYIEIR	CSMD2	2011	Q7Z408
HRYANVFLQPVTDDI	BRD8	726	Q9H0E9
YHFPIQFEDVYNALR	AADAC	151	P22760
HFLYEVARRNPFVFA	AFM	161	P43652
NLQAFLYFRPHEYNL	ARHGEF37	296	A1IGU5
QRPLFLYVAFQAVHT	ARSI	226	Q5FYB1
DRIYNRDIIHPTQDF	FAT4	4321	Q6V0I7
VRDQEHYREFPEANF	ABCA6	1176	Q8N139
NEVLRHQLFAAPYRD	ATN1	1111	P54259
ILYHQLGEIPADFFV	AAR2	301	Q9Y312
SEHFFLREPTALYVQ	ADGRV1	3081	Q8WXG9
HVEDLLFFYRQTLPD	ALMS1	671	Q8TCU4
DLQAGYFDPHFVRIF	C4orf47	56	A7E2U8
FFHFVLALYDRQGQP	EBF2	66	Q9HAK2
HYRRFFQNIIAVQDI	ABCA13	4726	Q86UQ4
FFHTDYRPLIRDANN	BRWD3	556	Q6RI45
RQLVPEYFNFAHDVL	ACSM5	46	Q6NUN0
QALPHELFQEFDYQP	ADCK5	191	Q3MIX3
FDYQPIAAASLAQVH	ADCK5	201	Q3MIX3
YSFLPLNLYEQFHRV	ATP8B3	146	O60423
LEFQLHEPFLLYRNA	DCP1A	86	Q9NPI6
PVFVYREIFTTDNHN	C3AR1	156	Q16581
EHNLDNTIYIPFARS	CCDC14	771	Q49A88
IDFSFVYLAHPRAVN	DMXL1	221	Q9Y485
EQFHRPANVYFVFIA	ATP10A	81	O60312
QEDFYLHLTPDAQFL	ADAMTS15	61	Q8TE58
ANIIIRDFYNPAIHI	CLDN17	141	P56750
ALEYFFEEKQPLQFH	CPNE6	76	O95741
FNEFYAHNARLTPLQ	MUC5B	216	Q9HC84
HVNNPFESFIIEIFY	RAD51AP2	501	Q09MP3
ANVNEILDFFHGYRI	RBM12B	936	Q8IXT5
RFPQAEHQDVKYLAI	RASAL1	451	O95294
FDILQPKEYFQLSRH	RAI2	291	Q9Y5P3
LHQPQVAAIFIISYF	NPFFR2	141	Q9Y5X5
REAAYNAITLPEEFH	RAD21	101	O60216
AYQHLPVRIFVALFD	TSPOAP1	1621	O95153
QEVDFFQRYFIADLP	INTS4	756	Q96HW7
FQRYFIADLPHLQDS	INTS4	761	Q96HW7
NDFIYHEAVPALDTL	PTPN23	316	Q9H3S7
FYHVQEQLPRDCFVV	HACL1	381	Q9UJ83
NFYALVTEHPLDREV	PCDHB18P	346	Q96TA0
YQAIFHAVDQYLALP	MCOLN1	126	Q9GZU1
LFPELFTHENLRKQY	BEND3	581	Q5T5X7
LLPIYHQVAVQFADF	ACACB	2286	O00763
RDLEIEVVLFHPNYN	CFB	546	P00751
FLNRYVPFDAAVDFH	DUOX1	1116	Q9NRD9
VLLIEFFELYGRHFN	TENT4B	311	Q8NDF8
PIQHELFERFLLYDQ	POLDIP2	191	Q9Y2S7
FDRYPDSILEHQIQV	MCM4	246	P33991
LNRFNYPFELEKDLH	NSUN3	56	Q9H649
EPHARFYAAQIVLTF	PRKACA	141	P17612
SIFKPIFYVLHQRDN	GPR82	266	Q96P67
VPRYLNDFYELELQH	HCFC2	156	Q9Y5Z7
VNPRALDFHAETNYI	LRP1B	556	Q9NZR2
NFAHFPRLFNLRSIY	LRRTM4	221	Q86VH4
PLNYHIVEVIFAELF	NCBP1	346	Q09161
PILYNLVSANFRHIF	NTSR1	361	P30989
PVFVQLLQGVFRVYH	ITPR1	1516	Q14643
NEDIAIFLLRHGAYF	LRRK1	206	Q38SD2
RNFHIFYQLLAGADE	MYO1A	196	Q9UBC5
ALIHQYLLDAFFTRP	HECW1	1351	Q76N89
LNAYFHQPEAIEEFP	MGMT	66	P16455
RLFQDLYPFIQGEHV	JCAD	206	Q9P266
IHIPEDTNLFFLYRI	B3GALNT1	281	O75752
RFALHDQLFYLNALE	PCYOX1L	436	Q8NBM8
AHLLEPFRQYYLQAE	PDCD7	421	Q8N8D1
KFRHNIAYFPQIVSV	ISOC2	26	Q96AB3
AFDRFVAIRNPLHYV	OR51H1	121	Q8NH63
PEYNFLINLDHVEFK	PDE3A	881	Q14432
PYIDFRIFHSQSEIE	PDE7A	86	Q13946
SDDHVIQYVNPAFER	PDE8B	286	O95263
DDFVPRYCEHFNILQ	CUL7	1166	Q14999
SARYYLVHQEPLENF	NRP2	261	O60462
LVSAIEEHFFQPQKY	PGM2	591	Q96G03
QQYFFDRDPDIFRHI	KCND2	81	Q9NZV8
IIFAFISDPNLYQHQ	MYADM	186	Q96S97
NANFLDHYLDVPVDL	LONP1	616	P36776
PHLEDFLLRINFNNY	TUBGCP6	1801	Q96RT7
YLQEQGFHAELLPIF	METTL25B	431	Q96FB5
TFEDYLHNVVFVPRK	INSR	731	P06213
PDASAVYLHDFQRFL	PLCG2	236	P16885
QLFVFYDHESRRVEP	HFE	56	Q30201
IENFLPLHYDYLQFA	P3H2	301	Q8IVL5
LNFHTYTEQRIQIFP	PPP1R21	271	Q6ZMI0
AYFQTDRPAEQFHLQ	ARHGAP32	1096	A7KAX9
RQDVLPNSDFLVHFY	RALGAPA2	1026	Q2PPJ7
FNLEKYLDHEQRDPF	PPP2R3A	1056	Q06190
LLLHAFYENNYIVPD	POLA1	791	P09884
AEYAHLVQAIIENPF	HSD17B10	231	Q99714
HQRFRNLIYVEFVGP	PEG3	46	Q9GZU2
VYEDPALSAIFLHNN	EXOC7	566	Q9UPT5
FKHPFAIENIIAREY	FOXB1	166	Q99853
LSLRNFPHNDYEDVF	PTPN20	56	Q4JDL3
PLELKHFRVFLENYQ	PTPN20	276	Q4JDL3
HLKVENAPIVNRFDY	FBXO38	961	Q6PIJ6
GYLPVVIDNFHNAFR	GALE	26	Q14376
NIFLPHEIRFYQGVA	EFCAB5	1131	A4FU69
LFSHYNQFIRPVENV	CHRNA6	41	Q15825
NRDAVQDFLHEIYFL	ATR	1241	Q13535
PFFHGRDNYDQLVRI	CSNK2A3	231	Q8NEV1
YQARFPEHELTFDPQ	HYOU1	116	Q9Y4L1
HNPDRAYDAVQLFAL	GNAZ	96	P19086
NDIRTFFPEYTHQLF	HAT1	46	O14929
LQAVNFPFLVRLEYA	PRKACB	96	P22694
EPHARFYAAQIVLTF	PRKACB	141	P22694
NFHKVIQDEEFYTLP	KLHL11	231	Q9NVR0
IQDEEFYTLPFHLIR	KLHL11	236	Q9NVR0
LLEAFNYQVLPFRQH	KLHL26	281	Q53HC5
VVNLDPAAEHFNYSV	GPN3	36	Q9UHW5
LRHENINPLLGFFYD	GUCY2F	601	P51841
NLFIYHLPQEFGDTE	CELF5	401	Q8N6W0
RENIAFELPQEFLQY	IFNK	61	Q9P0W0
RKHNLYFEAAFDVPL	BTD	211	P43251
YPNAVLRLRFNHFAT	ATRNL1	126	Q5VV63
AFDAEYQRNPHRVDL	EID2	191	Q8N6I1
PFNDHLTLAVAQYLE	FAAH2	506	Q6GMR7
NDNAPYFEHRVTIFT	DSC1	236	Q08554
AYVARLHLLDQVFFQ	FGD2	116	Q7Z6J4
YTFPAEHRFQNIDFA	GDA	106	Q9Y2T3
NYDFPRNIDVYVHRV	DDX53	541	Q86TM3
DYLHLNPDNFAIQLE	SPAM1	396	P38567
INNRLVYHDFFRDPL	ELP5	76	Q8TE02
QLHELAPSIFFYLVD	EMC1	661	Q8N766
LHEREFDQIYFIFPH	FDXACB1	76	Q9BRP7
FRVIPHDQSFIENYA	CAPN3	146	P20807
AVRPYCFIEFDNFIQ	SEC22A	106	Q96IW7
QPAVYLFVLDVSHNA	SEC24B	676	O95487
LIFLEHFNNQYPAAE	SLC13A4	291	Q9UKG4
EFIQNLVRYPELYNH	SGK3	96	Q96BR1
SYQLVKFEDIVHFPQ	DSEL	1121	Q8IZU8
YFPNELRNIFREQVH	IZUMO4	101	Q1ZYL8
VTHVYNFDFPRNIEE	DDX43	556	Q9NXZ2
NFDFPRNIEEYVHRI	DDX43	561	Q9NXZ2
FRDYFPIQLVKTHNL	DGAT2	136	Q96PD7
APADYFRILVQQFEV	NUP58	341	Q9BVL2
LAFDNRFVPIYGNHS	OVGP1	636	Q12889
RYTAEEALAHPFFQQ	PHKG1	276	Q16816
EALAHPFFQQYLVEE	PHKG1	281	Q16816
PFFQQYLVEEVRHFS	PHKG1	286	Q16816
DHVEFPVRQAAAIYL	IPO8	46	O15397
VHLPQEGAFENTLYF	MRC1	1416	P22897
INYDQLEENARLFHP	SHMT1	181	P34896
RQENLPDEIYHVYSF	NTMT1	206	Q9BV86
DNDIYFIPRNVVHQF	RSBN1L	661	Q6PCB5
HLYPREAQLEEQFYL	SARS2	151	Q9NP81
SIEVEFEYPFRLHQV	SYP	66	P08247
LEQRHPQLDYVFTLA	UTRN	2276	P46939
RHINIFNKDYIFVPV	SENP7	841	Q9BQF6
QHYQIPDDFVADVRL	TRIM33	1016	Q9UPN9
LFLQVPRSNYLHFQE	TEX47	21	Q8TBZ9
GIFTPDQHLRFLEFY	PPP4R4	326	Q6NUP7
FHAVYFPIDVENQYL	NPHP3	336	Q7Z494
RFVEEDHIPYINAFQ	TAF1B	236	Q53T94
QAFENNLFRAPIYLH	TAF1	741	P21675
EQLRPLPAHDYFEFF	UPF3A	86	Q9H1J1
PERLFNAEFEEPHNY	FYB2	316	Q5VWT5
EHDPQYAVILAFDVR	EIF5B	1026	O60841
SQRFQFEFPYVAHLR	PRDM8	161	Q9NQV8
SFQLAYLLQHPEERA	SH2D5	141	Q6ZV89
YFEFNVIREIQPAAF	SLITRK3	486	O94933
FITYEFLQEQVNPHR	SLC25A37	216	Q9NYZ2
FELVHIFLYVVQPRD	PROM1	56	O43490
IVFFGENLPEQFHRA	SIRT1	411	Q96EB6
HLQFFYADLTNPIRV	TENM1	2266	Q9UKZ4
VRAFLDFHALPYQVV	PTGES2	116	Q9H7Z7
AQVHYPFENKREFED	IARS1	536	P41252
YSPTQFQEQRLEHFR	IQANK1	516	A8MXQ7
QHIPEVYREAQFYEI	KCTD14	101	Q9BQ13
YTEAAHRAVLFPQQR	SRCAP	1951	Q6ZRS2
RNYQFDFLRPQHSLF	SF3A1	191	Q15459
YRERSFPHDVQFFDL	RIC8A	151	Q9NPQ8
VPLLKFYFHDNVRVA	RANBP6	716	O60518
FVQNVFVDTHDLRFP	SETDB1	1231	Q15047
TEDVRHYFPELLDFN	SNED1	131	Q8TER0
DNFFPGLFAYHNIRV	SSH1	346	Q8WYL5
RALYQHANVVFLDDP	ABCC8	841	Q09428
QEAREHLYLVLFFDN	BRPF1	1136	P55201
LNPVIYTIFNHDFRR	ADRA2A	436	P08913
VECHPYFNQRKLLDF	AKR1C1	191	Q04828
VECHPYFNQRKLLDF	AKR1C2	191	P52895
LPYEVRRAQEINHLF	ASPA	86	P45381
HAIIRDFYNPLVAEA	CLDN6	141	P56747
HAIIQDFYNPLVAEA	CLDN9	141	O95484
LAVADFLFNVFLPIH	CMKLR1	81	Q99788
PALYFRDTVEFNNHT	CMKLR2	171	P46091
FLGELFNQHPDVFYL	CHST7	116	Q9NS84
VRFPEFVQYLLDVHR	CHST8	306	Q9H2A9
QFEDFVRYLGDPNHR	CHST10	236	O43529
PDAFIQVALQLAFYR	CHAT	531	P28329
HLENATEYATLRFPQ	C11orf52	96	Q96A22
RQSEFQQLPYHRIFI	CNOT1	1981	A5YKK6
DALQERGFLPYHIFF	PGBD2	336	Q6P3X8
FNFSVAPLVDHLEEY	TMEM156	141	Q8N614
LSQLLAYRNGHFFPE	PIK3R4	261	Q99570
FQIVHADDPDYIVLQ	TULP1	491	O00294
TRREFPFEDITQHNY	TULP4	581	Q9NRJ4
IIELANHPYFVGVQF	CTPS2	511	Q9NRF8
FTAEARQQHRPFTYL	TBXAS1	456	P24557
YPEHRTNFFLLLQAV	XPO1	841	O14980
AFDVHLNAFYPLLVI	UNC50	156	Q53HI1
LFDYAFIQNSALRPH	ZNF596	171	Q8TC21
DVSPNRDFLTHFYNI	RALGAPA1	1161	Q6GYQ0
FEAEPRQHLYSVFDR	RBP3	801	P10745
LDYHLNQPFIFVLRD	SERPINF1	386	P36955
HFRNIPVNEKETLAY	SAP30L	146	Q9HAJ7
EFPGFTRQAYHQLAL	TEX52	51	A6NCN8
LYRLDENFQPIAQDH	PXDN	1081	Q92626
VYNLTQEFFRHDKPV	SMOX	146	Q9NWM0
PNHRLFQAFFEEIGI	ZBED8	306	Q8IZ13
AYPRLEIYQEDQIHF	TEX264	166	Q9Y6I9
YRDICPQVLDLFHFQ	TANGO6	371	Q9C0B7
VDEFDNLHQYVPRII	VIT	651	Q6UXI7
NRERVPFILTYDFVH	PIK3CD	926	O00329
HDPRNVFTQFYIFKI	TEX11	486	Q8IYF3
FYIDSYHFEQLPQRL	PREX2	1381	Q70Z35
QEDPEAFLLYHRGFQ	RRP8	271	O43159
SDPRLQHVLVYFFQN	USP28	821	Q96RU2
QHVLVYFFQNEAPKR	USP28	826	Q96RU2
LFAFLAHTQREAYAP	USP38	491	Q8NB14
AHTQREAYAPRIFFE	USP38	496	Q8NB14
REYHVQFFSNQPERA	NSD3	306	Q9BZ95
VRFQLPNVLFAYAHT	ZNHIT2	211	Q9UHR6
TVEELRNVNVFFPHF	UEVLD	21	Q8IX04
VVFVDPSFHYRAILQ	ZSWIM3	281	Q96MP5
IQYLFEQESFDHVPA	SH2D3C	281	Q8N5H7
NFHNLVLFIDPAQEY	UGGT2	481	Q9NYU1
LAPAHVDEQVFLYEN	ZBED1	636	O96006
FPIVQNHDTFDLYRK	ZNF614	121	Q8N883
FFRHQYFAPVVGLEE	VRTN	231	Q9H8Y1
GAEAYHFFILAQRQL	WDR35	1026	Q9P2L0
LPKDIFNHFVQLYRD	ZFYVE9	991	O95405
LDFFVPALHYEVDAQ	ULK3	311	Q6PHR2
YFNRHAVELPREIQS	TMEM108	516	Q6UXF1
RNHAYEPLASFLDFI	ATP6V0D1	86	P61421
FIGLPHLEYLFIENN	LGI1	111	O95970
IFFENHPYFRDLLEE	MX1	301	P20591
NEGERNFHIFYQLLA	MYO1H	196	Q8N1T3
EEFYFRVNPSNHRLL	NEDD4L	76	Q96PU5