Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	netrin receptor activity	UNC5D UNC5B	4.20e-05	6	34	2	GO:0005042
GeneOntologyMolecularFunction	odorant binding	OR8A1 OR8J3 OR8D1 OR8G1	6.24e-05	127	34	4	GO:0005549
GeneOntologyMolecularFunction	olfactory receptor activity	OR8A1 OR8J3 OR8D1 OR2M7 OR51Q1 OR8G1	7.87e-05	431	34	6	GO:0004984
GeneOntologyMolecularFunction	transmembrane signaling receptor activity	OR8A1 P2RY10 OR8J3 OR8D1 OR2M7 OR51Q1 UNC5D UNC5B OR8G1	3.27e-04	1353	34	9	GO:0004888
GeneOntologyMolecularFunction	G protein-coupled receptor activity	OR8A1 P2RY10 OR8J3 OR8D1 OR2M7 OR51Q1 OR8G1	6.14e-04	884	34	7	GO:0004930
GeneOntologyBiologicalProcess	detection of chemical stimulus involved in sensory perception of smell	OR8A1 OR8J3 OR8D1 OR2M7 OR51Q1 OR8G1	4.66e-05	432	32	6	GO:0050911
GeneOntologyBiologicalProcess	sensory perception of smell	OR8A1 OR8J3 OR8D1 OR2M7 OR51Q1 OR8G1	7.00e-05	465	32	6	GO:0007608
GeneOntologyBiologicalProcess	netrin-activated signaling pathway	UNC5D UNC5B	8.34e-05	9	32	2	GO:0038007
GeneOntologyBiologicalProcess	detection of chemical stimulus involved in sensory perception	OR8A1 OR8J3 OR8D1 OR2M7 OR51Q1 OR8G1	8.83e-05	485	32	6	GO:0050907
GeneOntologyBiologicalProcess	detection of chemical stimulus	OR8A1 OR8J3 OR8D1 OR2M7 OR51Q1 OR8G1	1.35e-04	524	32	6	GO:0009593
GeneOntologyBiologicalProcess	sensory perception of chemical stimulus	OR8A1 OR8J3 OR8D1 OR2M7 OR51Q1 OR8G1	1.70e-04	547	32	6	GO:0007606
GeneOntologyBiologicalProcess	sensory perception	OR8A1 ZFHX2 OR8J3 OR8D1 OR2M7 OR51Q1 OTOG OR8G1	1.78e-04	1072	32	8	GO:0007600
GeneOntologyBiologicalProcess	detection of stimulus involved in sensory perception	OR8A1 OR8J3 OR8D1 OR2M7 OR51Q1 OR8G1	2.38e-04	582	32	6	GO:0050906
GeneOntologyBiologicalProcess	positive regulation of monocyte chemotaxis	PLA2G7 DEFB124	5.78e-04	23	32	2	GO:0090026
Domain	UPA	UNC5D UNC5B	3.40e-05	5	35	2	PF17217
Domain	UPA	UNC5D UNC5B	3.40e-05	5	35	2	IPR033772
Domain	Olfact_rcpt	OR8A1 OR8J3 OR8D1 OR2M7 OR51Q1 OR8G1	8.09e-05	393	35	6	IPR000725
Domain	ZU5	UNC5D UNC5B	1.22e-04	9	35	2	SM00218
Domain	NHL_repeat_subgr	NHLRC2 TRIM2	1.22e-04	9	35	2	IPR013017
Domain	NHL	NHLRC2 TRIM2	1.52e-04	10	35	2	PF01436
Domain	NHL_repeat	NHLRC2 TRIM2	1.52e-04	10	35	2	IPR001258
Domain	ZU5	UNC5D UNC5B	1.52e-04	10	35	2	PS51145
Domain	-	PHF14 TRIM2 MID2 RNF207 PHF12 CHD5	1.68e-04	449	35	6	3.30.40.10
Domain	Znf_RING/FYVE/PHD	PHF14 TRIM2 MID2 RNF207 PHF12 CHD5	1.89e-04	459	35	6	IPR013083
Domain	GPCR_Rhodpsn_7TM	OR8A1 P2RY10 OR8J3 OR8D1 OR2M7 OR51Q1 OR8G1	2.07e-04	670	35	7	IPR017452
Domain	7tm_1	OR8A1 P2RY10 OR8J3 OR8D1 OR2M7 OR51Q1 OR8G1	2.21e-04	677	35	7	PF00001
Domain	ZU5_dom	UNC5D UNC5B	2.23e-04	12	35	2	IPR000906
Domain	ZU5	UNC5D UNC5B	2.23e-04	12	35	2	PF00791
Domain	G_PROTEIN_RECEP_F1_1	OR8A1 P2RY10 OR8J3 OR8D1 OR2M7 OR51Q1 OR8G1	2.37e-04	685	35	7	PS00237
Domain	Zinc_finger_PHD-type_CS	PHF14 PHF12 CHD5	2.43e-04	65	35	3	IPR019786
Domain	G_PROTEIN_RECEP_F1_2	OR8A1 P2RY10 OR8J3 OR8D1 OR2M7 OR51Q1 OR8G1	2.50e-04	691	35	7	PS50262
Domain	GPCR_Rhodpsn	OR8A1 P2RY10 OR8J3 OR8D1 OR2M7 OR51Q1 OR8G1	2.53e-04	692	35	7	IPR000276
Domain	NHL	NHLRC2 TRIM2	2.63e-04	13	35	2	PS51125
Domain	zf-B_box	TRIM2 MID2 RNF207	3.29e-04	72	35	3	PF00643
Domain	Bbox_C	TRIM2 MID2	3.53e-04	15	35	2	IPR003649
Domain	BBC	TRIM2 MID2	3.53e-04	15	35	2	SM00502
Domain	PHD	PHF14 PHF12 CHD5	3.71e-04	75	35	3	PF00628
Domain	Znf_PHD-finger	PHF14 PHF12 CHD5	4.32e-04	79	35	3	IPR019787
Domain	ZF_BBOX	TRIM2 MID2 RNF207	4.49e-04	80	35	3	PS50119
Domain	Znf_B-box	TRIM2 MID2 RNF207	4.65e-04	81	35	3	IPR000315
Domain	PHD	PHF14 PHF12 CHD5	6.13e-04	89	35	3	SM00249
Domain	Znf_PHD	PHF14 PHF12 CHD5	6.54e-04	91	35	3	IPR001965
Domain	-	NLRP11 UNC5D UNC5B	6.97e-04	93	35	3	1.10.533.10
Domain	ZF_PHD_2	PHF14 PHF12 CHD5	7.42e-04	95	35	3	PS50016
Domain	ZF_PHD_1	PHF14 PHF12 CHD5	7.64e-04	96	35	3	PS01359
Domain	DEATH-like_dom	NLRP11 UNC5D UNC5B	8.36e-04	99	35	3	IPR011029
Domain	DEATH	UNC5D UNC5B	1.16e-03	27	35	2	SM00005
Domain	Death	UNC5D UNC5B	1.74e-03	33	35	2	PF00531
Domain	Znf-RING_LisH	TRIM2 MID2	1.84e-03	34	35	2	IPR027370
Domain	zf-RING_UBOX	TRIM2 MID2	1.84e-03	34	35	2	PF13445
Domain	Death_domain	UNC5D UNC5B	2.30e-03	38	35	2	IPR000488
Domain	DEATH_DOMAIN	UNC5D UNC5B	2.30e-03	38	35	2	PS50017
Domain	-	NHLRC2 TRIM2	2.42e-03	39	35	2	2.120.10.30
Domain	RING	TRIM2 MID2 RNF207 CHD5	2.45e-03	305	35	4	SM00184
Domain	Znf_FYVE_PHD	PHF14 PHF12 CHD5	2.60e-03	147	35	3	IPR011011
Domain	Znf_RING	TRIM2 MID2 RNF207 CHD5	3.11e-03	326	35	4	IPR001841
Domain	6-blade_b-propeller_TolB-like	NHLRC2 TRIM2	3.35e-03	46	35	2	IPR011042
Domain	Znf_RING_CS	TRIM2 MID2 RNF207	3.48e-03	163	35	3	IPR017907
Domain	Znf_C3HC4_RING-type	TRIM2 MID2 RNF207	4.05e-03	172	35	3	IPR018957
Domain	TSP_1	UNC5D UNC5B	6.20e-03	63	35	2	PF00090
Domain	TSP1	UNC5D UNC5B	6.59e-03	65	35	2	SM00209
Domain	TSP1_rpt	UNC5D UNC5B	6.59e-03	65	35	2	IPR000884
Domain	TSP1	UNC5D UNC5B	6.59e-03	65	35	2	PS50092
Domain	BBOX	TRIM2 MID2	7.40e-03	69	35	2	SM00336
Domain	-	TRIM2 AMIGO3 MID2 UNC5D UNC5B	7.46e-03	663	35	5	2.60.40.10
Pathway	KEGG_OLFACTORY_TRANSDUCTION	OR8A1 OR8J3 OR8D1 OR2M7 OR51Q1 OR8G1	1.62e-05	389	21	6	M14091
Pathway	REACTOME_OLFACTORY_SIGNALING_PATHWAY	OR8A1 OR8J3 OR8D1 OR2M7 OR51Q1 OR8G1	2.40e-05	417	21	6	M4072
Pathway	REACTOME_SENSORY_PERCEPTION	OR8A1 OR8J3 OR8D1 OR2M7 OR51Q1 OTOG OR8G1	2.46e-05	636	21	7	M41834
Pathway	REACTOME_NETRIN_MEDIATED_REPULSION_SIGNALS	UNC5D UNC5B	5.89e-05	8	21	2	M27328
Pubmed	Different evolutionary processes shaped the mouse and human olfactory receptor gene families.	OR8A1 OR8J3 OR8D1 OR2M7 OR51Q1 OR8G1	1.07e-06	340	35	6	11875048
Pubmed	The olfactory receptor gene superfamily of the mouse.	OR8A1 OR8J3 OR8D1 OR2M7 OR51Q1 OR8G1	1.07e-06	340	35	6	11802173
Pubmed	A unified nomenclature for vertebrate olfactory receptors.	OR8A1 OR8J3 OR8D1 OR2M7 OR51Q1 OR8G1	1.12e-06	343	35	6	32295537
Pubmed	Odorant receptor expressed sequence tags demonstrate olfactory expression of over 400 genes, extensive alternate splicing and unequal expression levels.	OR8A1 OR8J3 OR8D1 OR2M7 OR51Q1 OR8G1	1.18e-06	346	35	6	14611657
Pubmed	Structural Basis of Latrophilin-FLRT-UNC5 Interaction in Cell Adhesion.	UNC5D UNC5B	5.90e-06	4	35	2	26235030
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	TINAGL1 STEAP3 AMBRA1 PIGG TNPO3 FANCI PHF12 CHD5	1.11e-05	1105	35	8	35748872
Pubmed	Peri-pubertal emergence of UNC-5 homologue expression by dopamine neurons in rodents.	UNC5D UNC5B	2.06e-05	7	35	2	20628609
Pubmed	Cloning of three mouse Unc5 genes and their expression patterns at mid-gestation.	UNC5D UNC5B	2.06e-05	7	35	2	12351186
Pubmed	FLRT structure: balancing repulsion and cell adhesion in cortical and vascular development.	UNC5D UNC5B	2.06e-05	7	35	2	25374360
Pubmed	Spatiotemporal expression of repulsive guidance molecules (RGMs) and their receptor neogenin in the mouse brain.	UNC5D UNC5B	3.53e-05	9	35	2	23457482
Pubmed	Characterization of a cluster comprising approximately 100 odorant receptor genes in mouse.	OR8D1 OR8G1	4.40e-05	10	35	2	11130974
Pubmed	Novel role for Netrins in regulating epithelial behavior during lung branching morphogenesis.	UNC5D UNC5B	5.38e-05	11	35	2	15186747
Pubmed	Analysis of Netrin 1 receptors during inner ear development.	UNC5D UNC5B	5.38e-05	11	35	2	17616930
Pubmed	Widespread Differential Expression of Coding Region and 3' UTR Sequences in Neurons and Other Tissues.	UNC5D UNC5B	6.45e-05	12	35	2	26687222
Pubmed	FLRT2 and FLRT3 act as repulsive guidance cues for Unc5-positive neurons.	UNC5D UNC5B	6.45e-05	12	35	2	21673655
Pubmed	Insertion of a neomycin selection cassette in the Amigo1 locus alters gene expression in the olfactory epithelium leading to region-specific defects in olfactory receptor neuron development.	OR8A1 AMIGO3	8.89e-05	14	35	2	38590146
Pubmed	FLRT2 and FLRT3 Cooperate in Maintaining the Tangential Migratory Streams of Cortical Interneurons during Development.	UNC5D UNC5B	1.02e-04	15	35	2	34301831
Pubmed	The human olfactory receptor gene family.	OR8A1 OR8J3 OR8D1 OR2M7 OR8G1	1.97e-04	541	35	5	14983052
Pubmed	Dynamic FoxG1 expression coordinates the integration of multipolar pyramidal neuron precursors into the cortical plate.	UNC5D UNC5B	2.24e-04	22	35	2	22726835
Pubmed	Synergistic integration of Netrin and ephrin axon guidance signals by spinal motor neurons.	UNC5D UNC5B	2.68e-04	24	35	2	26633881
Pubmed	Specific repertoire of olfactory receptor genes in the male germ cells of several mammalian species.	OR8D1 OR8G1	2.68e-04	24	35	2	9119360
Pubmed	Modulation of the combinatorial code of odorant receptor response patterns in odorant mixtures.	OR51Q1 OR8G1	3.40e-04	27	35	2	32061665
Pubmed	Functional interactions between ubiquitin E2 enzymes and TRIM proteins.	TRIM2 MID2	3.40e-04	27	35	2	21143188
Pubmed	Molecular signatures and cellular diversity during mouse habenula development.	ZFHX2 UNC5D	3.66e-04	28	35	2	35793630
Pubmed	The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.	TINAGL1 SCGB1D4 PIGG AMIGO3 UNC5D UNC5B	4.09e-04	985	35	6	12975309
Pubmed	Remotely Produced and Axon-Derived Netrin-1 Instructs GABAergic Neuron Migration and Dopaminergic Substantia Nigra Development.	UNC5D UNC5B	4.20e-04	30	35	2	32562661
Pubmed	Targeting the p300/NONO axis sensitizes melanoma cells to BRAF inhibitors.	AMBRA1 FANCI	4.20e-04	30	35	2	34017080
Pubmed	The Trim family of genes and the retina: Expression and functional characterization.	TRIM2 UNC5D	5.09e-04	33	35	2	30208054
Pubmed	Distinct expression of select and transcriptome-wide isolated 3'UTRs suggests critical roles in development and transition states.	UNC5D UNC5B	5.09e-04	33	35	2	33951080
Pubmed	The tripartite motif family identifies cell compartments.	TRIM2 MID2	7.87e-04	41	35	2	11331580
Cytoband	11q24.2	OR8A1 OR8D1 OR8G1	1.56e-05	63	35	3	11q24.2
Cytoband	1p36.31	RNF207 CHD5	5.11e-05	14	35	2	1p36.31
Cytoband	Ensembl 112 genes in cytogenetic band chr11q24	OR8A1 OR8D1 OR8G1	4.21e-04	191	35	3	chr11q24
GeneFamily	Olfactory receptors, family 8	OR8A1 OR8J3 OR8D1 OR8G1	1.42e-06	49	31	4	155
GeneFamily	PHD finger proteins	PHF14 PHF12 CHD5	4.85e-04	90	31	3	88
Computational	Genes in the cancer module 188.	P2RY10 ZFHX2 UNC5D	8.59e-04	139	15	3	MODULE_188
Computational	B lymphoma expression clusters.	P2RY10 ZFHX2 UNC5D	1.05e-03	149	15	3	MODULE_361
Computational	Genes in the cancer module 301.	P2RY10 ZFHX2 UNC5D	1.25e-03	158	15	3	MODULE_301
Computational	Genes in the cancer module 238.	P2RY10 ZFHX2 UNC5D	1.39e-03	164	15	3	MODULE_238
Disease	glutamate measurement	UNC5D OTOG	4.54e-04	29	32	2	EFO_0010487
Disease	cigarettes per day measurement	TINAGL1 AMBRA1 NSUN3 UNC5D	1.24e-03	438	32	4	EFO_0006525
Disease	snoring measurement	NSUN3 UNC5D	3.76e-03	84	32	2	EFO_0008341
Disease	age at menopause	NLRP11 TNPO3 FANCI	4.23e-03	302	32	3	EFO_0004704
Disease	hypertrophic cardiomyopathy	AMBRA1 RNF207	4.49e-03	92	32	2	EFO_0000538

Protein segments in the cluster

Peptide	Gene	Start	Entry
ILCDTCPRAYHLVCL	CHD5	356	Q8TDI0
GELLCCDACPSSYHL	CHD5	426	Q8TDI0
LHNCPYKCICAADLL	AMIGO3	31	Q86WK7
YPTAECCQHLGILCL	AMBRA1	296	Q9C0C7
HYFCDVLPLLNLSCS	OR8D1	176	Q8WZ84
QEPLDYLLCCIQHCL	FANCI	661	Q9NVI1
HYFCDLLPLLKLSCS	OR8G1	176	Q15617
SIALLQCACPGYLHC	NSUN3	146	Q9H649
YDDCCFLHLPDLCMT	KIAA0100	1196	Q14667
SLYCLDYCCHLRTLK	NLRP11	581	P59045
CYCGLCASIHLLKLL	EPHX4	26	Q8IUS5
HFCCDFPSLLILSCN	OR2M7	176	Q8NG81
SVDCYVAICCPLHYA	OR51Q1	121	Q8NH59
HFYCDIAPLLALSCS	OR8J3	176	Q8NGG0
LLCDTCKLHYHLGCL	PHF14	741	O94880
FTYCCINCIHLLPDL	NHLRC2	86	Q8NBF2
LHVLFCLCGCLAVVY	PLA2G7	6	Q13093
VALLYRCCFCGEDHP	NR0B1	126	P51843
HLCPDASLCCLSYAL	DEFB124	46	Q8NES8
CEHLISHYFCDILPL	OR8A1	186	Q8NGG7
RIALYFHPFCLCLAS	P2RY10	281	O00398
FHPFCLCLASLCCLL	P2RY10	286	O00398
QPCLCATLAHYAHLC	OTOG	746	Q6ZRI0
QYERPCLLDCFHDFC	RNF207	31	Q6ZRF8
DCALPYLGAICYCDL	TINAGL1	61	Q9GZM7
CSLEPHLNSDLCVYC	TCAF2	321	A6NFQ2
LIQCDYCPLLFHMDC	PHF12	286	Q96QT6
SLALCCYQAHALVCP	SCGB1D4	11	Q6XE38
PICTYHCLACEVLLS	ZFHX2	2491	Q9C0A1
FCAALHALYSFCLPL	STEAP3	311	Q658P3
CYCQLEPRACHILLD	UNC5B	661	Q8IZJ1
SCYCLLDPFACHVLL	UNC5D	656	Q6UXZ4
FCGKACPCLSIYLIH	ZNF844	201	Q08AG5
QLLHTCCFCLPPYTL	TNPO3	836	Q9Y5L0
CLCLYCHEYFKDCPS	S100A3	81	P33764
LPCLHTFCERCLQNY	TRIM2	36	Q9C040
LLLPCAHSLCFSCAH	MID2	41	Q9UJV3
LSHACFCYALICSIP	PIGG	916	Q5H8A4