Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	olfactory receptor activity	OR52W1 OR52P1 OR52Z1P OR52L2P OR52B2 OR52N1 OR9A2 OR52D1 OR52N2 OR52L1 OR52J3	2.19e-09	431	45	11	GO:0004984
GeneOntologyMolecularFunction	G protein-coupled receptor activity	OR52W1 OR52P1 OR52Z1P OR52L2P OR52B2 OR52N1 OR9A2 OR52D1 OR52N2 OR52L1 GP1BA OR52J3	3.92e-07	884	45	12	GO:0004930
GeneOntologyMolecularFunction	transmembrane signaling receptor activity	IL10RB OR52W1 OR52P1 OR52Z1P OR52L2P OR52B2 OR52N1 OR9A2 OR52D1 OR52N2 OR52L1 GP1BA OR52J3	5.65e-06	1353	45	13	GO:0004888
GeneOntologyBiologicalProcess	sensory perception of chemical stimulus	SCNN1D OR52W1 OR52P1 OR52Z1P OR52L2P OR52B2 OR52N1 OR9A2 OR52D1 OR52N2 OR52L1 OR52J3	7.79e-10	547	43	12	GO:0007606
GeneOntologyBiologicalProcess	detection of chemical stimulus involved in sensory perception of smell	OR52W1 OR52P1 OR52Z1P OR52L2P OR52B2 OR52N1 OR9A2 OR52D1 OR52N2 OR52L1 OR52J3	9.43e-10	432	43	11	GO:0050911
GeneOntologyBiologicalProcess	sensory perception of smell	OR52W1 OR52P1 OR52Z1P OR52L2P OR52B2 OR52N1 OR9A2 OR52D1 OR52N2 OR52L1 OR52J3	2.04e-09	465	43	11	GO:0007608
GeneOntologyBiologicalProcess	detection of chemical stimulus involved in sensory perception	OR52W1 OR52P1 OR52Z1P OR52L2P OR52B2 OR52N1 OR9A2 OR52D1 OR52N2 OR52L1 OR52J3	3.17e-09	485	43	11	GO:0050907
GeneOntologyBiologicalProcess	detection of chemical stimulus	OR52W1 OR52P1 OR52Z1P OR52L2P OR52B2 OR52N1 OR9A2 OR52D1 OR52N2 OR52L1 OR52J3	7.06e-09	524	43	11	GO:0009593
GeneOntologyBiologicalProcess	detection of stimulus involved in sensory perception	OR52W1 OR52P1 OR52Z1P OR52L2P OR52B2 OR52N1 OR9A2 OR52D1 OR52N2 OR52L1 OR52J3	2.08e-08	582	43	11	GO:0050906
GeneOntologyBiologicalProcess	detection of stimulus	OR52W1 OR52P1 OR52Z1P OR52L2P OR52B2 OR52N1 OR9A2 OR52D1 OR52N2 OR52L1 OR52J3	1.85e-07	722	43	11	GO:0051606
GeneOntologyBiologicalProcess	sensory perception	SCNN1D OR52W1 OR52P1 OR52Z1P OR52L2P OR52B2 OR52N1 OR9A2 OR52D1 OR52N2 OR52L1 OR52J3	1.25e-06	1072	43	12	GO:0007600
GeneOntologyBiologicalProcess	G protein-coupled receptor signaling pathway	OR52W1 OR52P1 OR52Z1P OR52L2P OR52B2 OR52N1 OR9A2 OR52D1 OR52N2 OR52L1 GP1BA OR52J3	1.87e-05	1395	43	12	GO:0007186
GeneOntologyBiologicalProcess	neural crest cell migration involved in autonomic nervous system development	SEMA3A FN1	8.86e-05	7	43	2	GO:1901166
MousePheno	hemorrhage	TRIM71 FRAS1 EVC2 FN1 ZFP36L2 SZT2 HYDIN	6.65e-05	664	23	7	MP:0001914
MousePheno	subcutaneous hemorrhage	FRAS1 ZFP36L2	9.26e-05	9	23	2	MP:0031152
Domain	Olfact_rcpt	OR52W1 OR52B2 OR52N1 OR9A2 OR52D1 OR52N2 OR52L1 OR52J3	1.86e-06	393	41	8	IPR000725
Domain	GPCR_Rhodpsn_7TM	OR52W1 OR52B2 OR52N1 OR9A2 OR52D1 OR52N2 OR52L1 OR52J3	8.80e-05	670	41	8	IPR017452
Domain	7tm_1	OR52W1 OR52B2 OR52N1 OR9A2 OR52D1 OR52N2 OR52L1 OR52J3	9.46e-05	677	41	8	PF00001
Domain	G_PROTEIN_RECEP_F1_1	OR52W1 OR52B2 OR52N1 OR9A2 OR52D1 OR52N2 OR52L1 OR52J3	1.03e-04	685	41	8	PS00237
Domain	G_PROTEIN_RECEP_F1_2	OR52W1 OR52B2 OR52N1 OR9A2 OR52D1 OR52N2 OR52L1 OR52J3	1.09e-04	691	41	8	PS50262
Domain	GPCR_Rhodpsn	OR52W1 OR52B2 OR52N1 OR9A2 OR52D1 OR52N2 OR52L1 OR52J3	1.10e-04	692	41	8	IPR000276
Domain	PapD-like	HYDIN CFAP65	1.68e-04	9	41	2	IPR008962
Domain	-	SEMA3A IL10RB TRIM71 MXRA5 FN1 TNR	3.05e-03	663	41	6	2.60.40.10
Domain	Ig-like_fold	SEMA3A IL10RB TRIM71 MXRA5 FN1 TNR	4.15e-03	706	41	6	IPR013783
Pathway	REACTOME_OLFACTORY_SIGNALING_PATHWAY	OR52W1 OR52Z1P OR52B2 OR52N1 OR9A2 OR52D1 OR52N2 OR52L1 OR52J3	4.33e-07	417	34	9	M4072
Pathway	REACTOME_SENSORY_PERCEPTION	SCNN1D OR52W1 OR52Z1P OR52B2 OR52N1 OR9A2 OR52D1 OR52N2 OR52L1 OR52J3	1.60e-06	636	34	10	M41834
Pathway	KEGG_OLFACTORY_TRANSDUCTION	OR52W1 OR52B2 OR52N1 OR9A2 OR52D1 OR52N2 OR52L1 OR52J3	3.03e-06	389	34	8	M14091
Pubmed	The human olfactory receptor gene family.	OR52W1 OR52P1 OR52Z1P OR52L2P OR52B2 OR52N1 OR9A2 OR52D1 OR52N2 OR52L1 OR52J3	7.34e-11	541	45	11	14983052
Pubmed	Different evolutionary processes shaped the mouse and human olfactory receptor gene families.	OR52W1 OR52P1 OR52Z1P OR52B2 OR9A2 OR52D1 OR52N2 OR52L1 OR52J3	4.77e-10	340	45	9	11875048
Pubmed	The olfactory receptor gene superfamily of the mouse.	OR52W1 OR52P1 OR52Z1P OR52B2 OR9A2 OR52D1 OR52N2 OR52L1 OR52J3	4.77e-10	340	45	9	11802173
Pubmed	A unified nomenclature for vertebrate olfactory receptors.	OR52W1 OR52P1 OR52Z1P OR52B2 OR9A2 OR52D1 OR52N2 OR52L1 OR52J3	5.15e-10	343	45	9	32295537
Pubmed	Odorant receptor expressed sequence tags demonstrate olfactory expression of over 400 genes, extensive alternate splicing and unequal expression levels.	OR52W1 OR52P1 OR52Z1P OR52B2 OR9A2 OR52D1 OR52N2 OR52L1 OR52J3	5.56e-10	346	45	9	14611657
Pubmed	E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.	RCE1 MXRA5 FN1 CSMD2 TNR OR52N1 OR52L1 GP1BA	4.18e-06	736	45	8	29676528
Pubmed	TGF beta in murine morphogenetic processes: the early embryo and cardiogenesis.	FN1 TNR	4.91e-06	3	45	2	1696875
Pubmed	Plasma fibronectin depletion enhances platelet aggregation and thrombus formation in mice lacking fibrinogen and von Willebrand factor.	FN1 GP1BA	1.63e-05	5	45	2	19036705
Pubmed	Sall1 balances self-renewal and differentiation of renal progenitor cells.	SEMA3A FRAS1 FN1	9.15e-05	67	45	3	24550112
Pubmed	Identification of fetal and maternal single nucleotide polymorphisms in candidate genes that predispose to spontaneous preterm labor with intact membranes.	FN1 MMP17 TNR GP1BA	9.94e-05	186	45	4	20452482
Pubmed	A genetic association study of maternal and fetal candidate genes that predispose to preterm prelabor rupture of membranes (PROM).	FN1 MMP17 TNR GP1BA	9.94e-05	186	45	4	20673868
Pubmed	Sprouty1 haploinsufficiency prevents renal agenesis in a model of Fraser syndrome.	FRAS1 FN1	1.70e-04	15	45	2	23064016
Pubmed	Comparative structural and functional analysis of the olfactory receptor genes flanking the human and mouse beta-globin gene clusters.	OR52Z1P OR52D1	1.70e-04	15	45	2	11121057
Pubmed	ADAMTS2 promotes radial migration by activating TGF-β signaling in the developing neocortex.	FN1 MMP17	1.70e-04	15	45	2	38871984
Pubmed	Conservation of sequence and structure flanking the mouse and human beta-globin loci: the beta-globin genes are embedded within an array of odorant receptor genes.	OR52Z1P OR52D1	1.70e-04	15	45	2	10220430
Pubmed	Natural selection on the olfactory receptor gene family in humans and chimpanzees.	OR9A2 OR52L1	2.20e-04	17	45	2	12908129
Pubmed	Differential expansion of zinc-finger transcription factor loci in homologous human and mouse gene clusters.	ZNF223 ZNF230	3.06e-04	20	45	2	12743021
Pubmed	Fras1, a basement membrane-associated protein mutated in Fraser syndrome, mediates both the initiation of the mammalian kidney and the integrity of renal glomeruli.	FRAS1 FN1	4.07e-04	23	45	2	18787044
Pubmed	AMPK Interactome Reveals New Function in Non-homologous End Joining DNA Repair.	SCNN1D MXRA5 NCCRP1	5.24e-04	121	45	3	31900314
Pubmed	Basement membrane assembly of the integrin α8β1 ligand nephronectin requires Fraser syndrome-associated proteins.	FRAS1 FN1	6.50e-04	29	45	2	22613833
Pubmed	In vitro differentiation of mouse pluripotent stem cells into corticosteroid-producing adrenocortical cells.	FN1 CYP11B2	1.06e-03	37	45	2	39178848
Cytoband	11p15.4	OR52W1 OR52P1 OR52Z1P OR52L2P OR52B2 OR52N1 OR52D1 OR52N2 OR52L1 OR52J3	5.48e-15	200	45	10	11p15.4
Cytoband	Ensembl 112 genes in cytogenetic band chr11p15	OR52W1 OR52P1 OR52Z1P OR52L2P OR52B2 OR52N1 OR52D1 OR52N2 OR52L1 OR52J3	1.57e-10	564	45	10	chr11p15
Cytoband	1p34.2	SZT2 ZNF691	1.45e-03	57	45	2	1p34.2
Cytoband	Ensembl 112 genes in cytogenetic band chr19q13	ZNF765 ZNF223 FUT1 ZNF230 NCCRP1	6.05e-03	1192	45	5	chr19q13
Cytoband	Ensembl 112 genes in cytogenetic band chr2q35	FN1 CFAP65	7.17e-03	129	45	2	chr2q35
GeneFamily	Olfactory receptors, family 52	OR52W1 OR52P1 OR52Z1P OR52L2P OR52B2 OR52N1 OR52D1 OR52N2 OR52L1 OR52J3	2.65e-18	49	37	10	165
Disease	attention deficit hyperactivity disorder	SEMA3A TRIM71 CSMD2 TNR	9.84e-04	354	37	4	EFO_0003888

Protein segments in the cluster

Peptide	Gene	Start	Entry
GVFFTFHTFHLESGH	CSMD2	961	Q7Z408
TFFHKHLGGHEGTIP	ACOT2	466	P49753
SHFFTVHIPAAVGHP	AADACL3	26	Q5VUY0
SFLAHRFGGKTIPHH	OR52Z1P	241	P0C646
IPAFFSFLTHRFGHH	OR52D1	256	Q9H346
LFSYLTHRFGHHTVP	OR52W1	261	Q6IF63
EGGRAPLSFHHFFAT	FRAS1	1846	Q86XX4
HFDSPRGVAFNHEGH	TRIM71	746	Q2Q1W2
IFVHASGFTGGHHTR	MYG1	341	Q9HB07
ARGHSYFAGFEHHIP	CFAP65	761	Q6ZU64
SHVFRHYGPGVRFIH	NCCRP1	231	Q6ZVX7
PLFFGVAHFHHIIEQ	RCE1	201	Q9Y256
PSFFTLLTHHFGRNI	OR52B2	256	Q96RD2
VLPHHGLHAAGFFIA	EVC2	291	Q86UK5
FHGGHFVHMRGLPFR	HNRNPH3	191	P31942
FFTHRFVGHNIPNHI	OR52N2	261	Q8NGI0
PALFSFFTHRFGHHV	OR52P1	256	Q8NH57
PGLFDIIGHSHQLFH	PAQR9	301	Q6ZVX9
FGHRFSHRGAHTLAG	SBF1	1461	O95248
ALHFGDVSFGFPHTL	HYDIN	571	Q4G0P3
ITGYRIRHHPEHFSG	FN1	1476	P02751
GHPHHNTLLFFSFPL	IL10RB	271	Q08334
GFFGSHLLPFAFLHG	GP1BA	206	P07359
IRGSGRNFHHVPFGF	CYP11B2	431	P19099
RNHTPFLGHHSFSVR	SCNN1D	496	P51172
FHLLGFPGSQGLHHI	OR9A2	11	Q8NGT5
SVFSFLTHRFGHQIP	OR52J3	256	Q8NH60
VPGIFSFLTHRFGHH	OR52L1	271	Q8NGH7
IPGMFSFLTHRFGHH	OR52L2P	271	Q8NGH6
FFTHHFGGHTIPLHI	OR52N1	261	Q8NH53
VIFFLHIHQDSFPHG	FUT1	21	P19526
LTTFLRHFLAHHPDG	SZT2	3071	Q5T011
FSAGTGSAILPHFHH	PLAGL1	446	Q9UM63
FFPGHHHTAGDTHFD	MMP17	211	Q9ULZ9
RLGHFIASHPVFFAS	PTCHD1	16	Q96NR3
LFGERHHFSFPSIFI	ORC5	21	O43913
GRDFAIFRTLGHHHP	SEMA3A	196	Q14563
SVGHQPFHRDTFHFL	ZNF223	46	Q9UK11
SFGVHHRTHTGERPY	ZNF691	241	Q5VV52
HFRGSPGVVHLVAFH	TBL3	146	Q12788
FTGFRPISHLHFSHV	TNR	771	Q92752
SVGHQPFHPFHFLRE	ZNF230	46	Q9UIE0
GFSFHSHLPELHIFH	ZNF765	141	Q7L2R6
FAHGFHELRSLTRHP	ZFP36L2	176	P47974
RIHSHSTFHLDFGPP	MXRA5	1771	Q9NR99