Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	neuron projection morphogenesis	TANC2 CACNA1A ABLIM1 MEGF8 NFATC4 LAMA2 PRKN ULK2 DICER1 SHANK3 PLXNA1	1.74e-06	802	48	11	GO:0048812
GeneOntologyBiologicalProcess	plasma membrane bounded cell projection morphogenesis	TANC2 CACNA1A ABLIM1 MEGF8 NFATC4 LAMA2 PRKN ULK2 DICER1 SHANK3 PLXNA1	2.13e-06	819	48	11	GO:0120039
GeneOntologyBiologicalProcess	cell projection morphogenesis	TANC2 CACNA1A ABLIM1 MEGF8 NFATC4 LAMA2 PRKN ULK2 DICER1 SHANK3 PLXNA1	2.31e-06	826	48	11	GO:0048858
GeneOntologyBiologicalProcess	neuron development	TANC2 CACNA1A ABLIM1 DZANK1 MEGF8 NFATC4 AP5Z1 LAMA2 PRKN ULK2 DICER1 SHANK3 PLXNA1	2.01e-05	1463	48	13	GO:0048666
GeneOntologyBiologicalProcess	neuron projection development	TANC2 CACNA1A ABLIM1 MEGF8 NFATC4 AP5Z1 LAMA2 PRKN ULK2 DICER1 SHANK3 PLXNA1	2.78e-05	1285	48	12	GO:0031175
GeneOntologyBiologicalProcess	regulation of anatomical structure morphogenesis	TANC2 CACNA1A AGO1 MEGF8 NFATC4 BTBD7 PRKN ULK2 DICER1 SHANK3 PLXNA1	3.17e-05	1090	48	11	GO:0022603
GeneOntologyBiologicalProcess	cell morphogenesis involved in neuron differentiation	TANC2 CACNA1A ABLIM1 MEGF8 NFATC4 LAMA2 ULK2 SHANK3 PLXNA1	4.87e-05	748	48	9	GO:0048667
GeneOntologyBiologicalProcess	regulation of nervous system process	SMR3A PRKN DICER1 SHANK3 SMR3B	5.29e-05	175	48	5	GO:0031644
GeneOntologyBiologicalProcess	cell morphogenesis	TANC2 CACNA1A ABLIM1 MEGF8 NFATC4 LAMA2 PRKN ULK2 DICER1 SHANK3 PLXNA1	7.27e-05	1194	48	11	GO:0000902
GeneOntologyBiologicalProcess	miRNA metabolic process	NCOR1 AGO1 NFATC4 DICER1	1.68e-04	119	48	4	GO:0010586
GeneOntologyBiologicalProcess	RISC complex assembly	AGO1 DICER1	2.36e-04	10	48	2	GO:0070922
GeneOntologyBiologicalProcess	positive regulation of transcription by RNA polymerase II	ABLIM1 AGO1 RBMXL1 NFATC4 CDK13 ZMIZ2 RBMX ZNF629 PRKN DICER1 EBF4	2.78e-04	1390	48	11	GO:0045944
GeneOntologyCellularComponent	supraspliceosomal complex	RBMXL1 RBMX	3.09e-05	4	48	2	GO:0044530
GeneOntologyCellularComponent	type III intermediate filament	DES PRPH	7.70e-05	6	48	2	GO:0045098
GeneOntologyCellularComponent	postsynaptic density, intracellular component	TANC2 DICER1 SHANK3	1.94e-04	49	48	3	GO:0099092
GeneOntologyCellularComponent	RISC-loading complex	AGO1 DICER1	2.30e-04	10	48	2	GO:0070578
GeneOntologyCellularComponent	postsynaptic specialization, intracellular component	TANC2 DICER1 SHANK3	2.89e-04	56	48	3	GO:0099091
GeneOntologyCellularComponent	postsynaptic density	TANC2 ABLIM1 RBMX PRKN DICER1 SHANK3	5.56e-04	451	48	6	GO:0014069
GeneOntologyCellularComponent	asymmetric synapse	TANC2 ABLIM1 RBMX PRKN DICER1 SHANK3	7.45e-04	477	48	6	GO:0032279
GeneOntologyCellularComponent	postsynaptic specialization	TANC2 ABLIM1 RBMX PRKN DICER1 SHANK3	9.81e-04	503	48	6	GO:0099572
GeneOntologyCellularComponent	neuron to neuron synapse	TANC2 ABLIM1 RBMX PRKN DICER1 SHANK3	1.20e-03	523	48	6	GO:0098984
GeneOntologyCellularComponent	postsynapse	TANC2 CACNA1A ABLIM1 RBMX LAMA2 PRKN DICER1 SHANK3	2.05e-03	1018	48	8	GO:0098794
GeneOntologyCellularComponent	glutamatergic synapse	TANC2 CACNA1A RBMX PRKN DICER1 SHANK3 PLXNA1	2.47e-03	817	48	7	GO:0098978
GeneOntologyCellularComponent	nuclear speck	SETD1B NFATC4 CDK13 AP5Z1 PRKN	3.01e-03	431	48	5	GO:0016607
GeneOntologyCellularComponent	endoribonuclease complex	AGO1 DICER1	3.27e-03	37	48	2	GO:1902555
Domain	SMR-like	SMR3A SMR3B	1.94e-05	3	48	2	IPR026288
Domain	PROL5-SMR	SMR3A SMR3B	1.94e-05	3	48	2	PF15621
Domain	IPT	NFATC4 PLXNA1 EBF4	4.46e-05	27	48	3	SM00429
Domain	TIG	NFATC4 PLXNA1 EBF4	6.81e-05	31	48	3	PF01833
Domain	IPT	NFATC4 PLXNA1 EBF4	7.50e-05	32	48	3	IPR002909
Domain	Filament_head	DES PRPH	1.35e-04	7	48	2	PF04732
Domain	Intermed_filament_DNA-bd	DES PRPH	1.35e-04	7	48	2	IPR006821
Domain	RBM1CTR	RBMXL1 RBMX	1.79e-04	8	48	2	PF08081
Domain	RBM1CTR	RBMXL1 RBMX	1.79e-04	8	48	2	IPR012604
Domain	PAZ	AGO1 DICER1	2.30e-04	9	48	2	PS50821
Domain	PAZ	AGO1 DICER1	2.30e-04	9	48	2	SM00949
Domain	PAZ_dom	AGO1 DICER1	2.30e-04	9	48	2	IPR003100
Domain	PAZ	AGO1 DICER1	2.30e-04	9	48	2	PF02170
Domain	RRM_dom_euk	RBMXL1 RBMX	1.58e-03	23	48	2	IPR003954
Domain	RRM_1	RBMXL1 RBMX	1.58e-03	23	48	2	SM00361
Domain	Ig_E-set	NFATC4 PLXNA1 EBF4	2.42e-03	104	48	3	IPR014756
Domain	EGF_LAM_2	MEGF8 LAMA2	2.69e-03	30	48	2	PS50027
Domain	EGF_LAM_1	MEGF8 LAMA2	2.69e-03	30	48	2	PS01248
Domain	PSI	MEGF8 PLXNA1	3.05e-03	32	48	2	PF01437
Domain	Plexin_repeat	MEGF8 PLXNA1	3.05e-03	32	48	2	IPR002165
Domain	Laminin_EGF	MEGF8 LAMA2	3.65e-03	35	48	2	PF00053
Domain	EGF_Lam	MEGF8 LAMA2	3.65e-03	35	48	2	SM00180
Domain	Laminin_EGF	MEGF8 LAMA2	4.29e-03	38	48	2	IPR002049
Domain	PSI	MEGF8 PLXNA1	5.71e-03	44	48	2	IPR016201
Pathway	BIOCARTA_DICER_PATHWAY	AGO1 DICER1	4.36e-05	5	30	2	M22079
Pathway	REACTOME_SMALL_INTERFERING_RNA_SIRNA_BIOGENESIS	AGO1 DICER1	1.56e-04	9	30	2	M27340
Pathway	WP_22Q112_COPY_NUMBER_VARIATION_SYNDROME	NCOR1 PRKN RORC PPP1CB	1.57e-04	130	30	4	M39787
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	TANC2 ZXDC NCOR1 EHBP1L1 SCAP SETD1B MEGF8 CDK13 BTBD7 ZMIZ2 ULK2 PLXNA1 PRRT4	2.85e-09	1105	49	13	35748872
Pubmed	Evolutionary conservation of a unique amino acid sequence in human DICER protein essential for binding to Argonaute family proteins.	AGO1 DICER1	1.94e-06	2	49	2	17482383
Pubmed	Ablation of Shank3 alleviates cardiac dysfunction in aging mice by promoting CaMKII activation and Parkin-mediated mitophagy.	PRKN SHANK3	1.94e-06	2	49	2	36436456
Pubmed	Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics.	TANC2 CACNA1A NCOR1 AGO1 SETD1B TMEM121B PRRC2A	4.44e-06	475	49	7	31040226
Pubmed	Myocardium defects and ventricular hypoplasia in mice homozygous null for the Forkhead Box M1 transcription factor.	DES NFATC4 LAMA2	5.21e-06	24	49	3	17366632
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	TANC2 SCAP CDK13 ZNF629 CTIF SHANK3 NCOA5	5.66e-06	493	49	7	15368895
Pubmed	EIF2C, Dicer, and Drosha are up-regulated along tumor progression and associated with poor prognosis in bladder carcinoma.	AGO1 DICER1	5.83e-06	3	49	2	25656609
Pubmed	The hepatic circadian clock fine-tunes the lipogenic response to feeding through RORα/γ.	SCAP RORC	5.83e-06	3	49	2	28747429
Pubmed	Transcriptional control of CBX5 by the RNA binding proteins RBMX and RBMXL1 maintains chromatin state in myeloid leukemia.	RBMXL1 RBMX	5.83e-06	3	49	2	34458856
Pubmed	RBMX is a novel hepatic transcriptional regulator of SREBP-1c gene response to high-fructose diet.	RBMXL1 RBMX	5.83e-06	3	49	2	17188681
Pubmed	RBMY evolved on the Y chromosome from a ubiquitously transcribed X-Y identical gene.	RBMXL1 RBMX	5.83e-06	3	49	2	10391207
Pubmed	Sirt3 deficiency exacerbates diabetic cardiac dysfunction: Role of Foxo3A-Parkin-mediated mitophagy.	PRKN SIRT3	5.83e-06	3	49	2	27794418
Pubmed	Molecular architecture of CAG repeats in human disease related transcripts.	CACNA1A ATN1	5.83e-06	3	49	2	15223312
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	TANC2 CACNA1A NCOR1 ABLIM1 DZANK1 AGO1 PRRC2A SHANK3 PPP1CB	7.00e-06	963	49	9	28671696
Pubmed	MicroRNAs are mediators of androgen action in prostate and muscle.	NCOR1 DICER1	1.16e-05	4	49	2	21048966
Pubmed	Argonaute, Dicer, and Drosha are up-regulated along tumor progression in serous ovarian carcinoma.	AGO1 DICER1	1.16e-05	4	49	2	22647351
Pubmed	SAFB1, an RBMX-binding protein, is a newly identified regulator of hepatic SREBP-1c gene.	RBMXL1 RBMX	1.16e-05	4	49	2	19403048
Pubmed	Type III Intermediate Filaments Desmin, Glial Fibrillary Acidic Protein (GFAP), Vimentin, and Peripherin.	DES PRPH	1.16e-05	4	49	2	29196434
Pubmed	N-CoR controls differentiation of neural stem cells into astrocytes.	NCOR1 PPP1CB	1.16e-05	4	49	2	12410313
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	NCOR1 ABLIM1 TRAFD1 ATN1 CDK13 RBMX PRRC2A PPP1CB	1.17e-05	774	49	8	15302935
Pubmed	Short-interfering-RNA-mediated gene silencing in mammalian cells requires Dicer and eIF2C translation initiation factors.	AGO1 DICER1	1.94e-05	5	49	2	12526743
Pubmed	Differential expression of Dicer and Argonaute genes during the differentiation of human neuroblastoma cells.	AGO1 DICER1	1.94e-05	5	49	2	19393748
Pubmed	Mst1 inhibits Sirt3 expression and contributes to diabetic cardiomyopathy through inhibiting Parkin-dependent mitophagy.	PRKN SIRT3	1.94e-05	5	49	2	29674007
Pubmed	Differential expression of components of the microRNA machinery during mouse organogenesis.	AGO1 DICER1	1.94e-05	5	49	2	16036130
Pubmed	Quantitative functions of Argonaute proteins in mammalian development.	AGO1 DICER1	1.94e-05	5	49	2	22474261
Pubmed	Expression of laminin isoforms in mouse myogenic cells in vitro and in vivo.	DES LAMA2	1.94e-05	5	49	2	8719886
Pubmed	A role for BCL2L13 and autophagy in germline purifying selection of mtDNA.	PRKN ULK2	1.94e-05	5	49	2	36608143
Pubmed	Human prion protein binds Argonaute and promotes accumulation of microRNA effector complexes.	AGO1 DICER1	1.94e-05	5	49	2	22484317
Pubmed	Pooled-matrix protein interaction screens using Barcode Fusion Genetics.	DES NCOR1 ARHGEF5 RBMX TNS2 PPP1CB	2.66e-05	419	49	6	27107012
Pubmed	Upregulation of Cyclin B1 by miRNA and its implications in cancer.	AGO1 DICER1	2.91e-05	6	49	2	22053081
Pubmed	Mice deficient in the chemokine receptor CXCR4 exhibit impaired limb innervation and myogenesis.	DES PRPH	4.07e-05	7	49	2	16198599
Pubmed	Genetic testing in spinocerebellar ataxia in Taiwan: expansions of trinucleotide repeats in SCA8 and SCA17 are associated with typical Parkinson's disease.	CACNA1A ATN1	4.07e-05	7	49	2	14756671
Pubmed	Defective signaling through plexin-A1 compromises the development of the peripheral olfactory system and neuroendocrine reproductive axis in mice.	PLXNA1 PRPH	4.07e-05	7	49	2	28334861
Pubmed	MEGF8 is a modifier of BMP signaling in trigeminal sensory neurons.	MEGF8 PRPH	4.07e-05	7	49	2	24052814
Pubmed	Mitochondrial processing peptidase regulates PINK1 processing, import and Parkin recruitment.	PMPCA PRKN	4.07e-05	7	49	2	22354088
Pubmed	Distinct alpha 7A beta 1 and alpha 7B beta 1 integrin expression patterns during mouse development: alpha 7A is restricted to skeletal muscle but alpha 7B is expressed in striated muscle, vasculature, and nervous system.	DES LAMA2	4.07e-05	7	49	2	8950511
Pubmed	mTORC1 activity regulates post-translational modifications of glycine decarboxylase to modulate glycine metabolism and tumorigenesis.	ABLIM1 AGO1 ZNF629 PRRC2A SIRT3	4.20e-05	274	49	5	34244482
Pubmed	New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules.	AGO1 RBMXL1 RBMX PRRC2A DICER1 NCOA5	4.59e-05	462	49	6	31138677
Pubmed	Black carbon exposures, blood pressure, and interactions with single nucleotide polymorphisms in MicroRNA processing genes.	AGO1 DICER1	5.42e-05	8	49	2	20211803
Pubmed	Suppression of microRNA Activity in Kidney Collecting Ducts Induces Partial Loss of Epithelial Phenotype and Renal Fibrosis.	AGO1 DICER1	5.42e-05	8	49	2	29021386
Pubmed	Identification of eight members of the Argonaute family in the human genome.	AGO1 DICER1	6.96e-05	9	49	2	12906857
Pubmed	Identification of quantitative trait loci controlling cortical motor evoked potentials in experimental autoimmune encephalomyelitis: correlation with incidence, onset and severity of disease.	CACNA1A PRPH	6.96e-05	9	49	2	15917267
Pubmed	Nestin mRNA expression correlates with the central nervous system progenitor cell state in many, but not all, regions of developing central nervous system.	DES PRPH	6.96e-05	9	49	2	7720210
Pubmed	Association of a common AGO1 variant with lung cancer risk: a two-stage case-control study.	AGO1 DICER1	8.69e-05	10	49	2	20721975
Pubmed	MicroRNA-132 is enriched in developing axons, locally regulates Rasa1 mRNA, and promotes axon extension.	DICER1 PRPH	8.69e-05	10	49	2	24381269
Pubmed	Screening for premutation in the FMR1 gene in male patients suspected of spinocerebellar ataxia.	CACNA1A ATN1	8.69e-05	10	49	2	19235102
Pubmed	Transient reduction of placental angiogenesis in PAI-1-deficient mice.	DES CEACAM21	1.06e-04	11	49	2	21119013
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	EHBP1L1 AGO1 RBMXL1 RBMX ZNF629 PPP1CB PRPH NCOA5	1.24e-04	1082	49	8	38697112
Pubmed	PLXNA1 and PLXNA3 cooperate to pattern the nasal axons that guide gonadotropin-releasing hormone neurons.	PLXNA1 PRPH	1.27e-04	12	49	2	31690636
Pubmed	Paracrine Hedgehog signaling in stomach and intestine: new roles for hedgehog in gastrointestinal patterning.	DES PRPH	1.27e-04	12	49	2	19445942
Pubmed	Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations.	TANC2 CACNA1A ABLIM1 TMEM121B PRRC2A	1.28e-04	347	49	5	17114649
Pubmed	Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.	ZXDC NCOR1 ABLIM1 BTBD7 ZMIZ2 ZDHHC14 PLXNA1	1.31e-04	808	49	7	20412781
Pubmed	Basal lamina molecules are concentrated in myogenic regions of the mouse limb bud.	DES LAMA2	1.50e-04	13	49	2	9833687
Pubmed	A medullary centre for lapping in mice.	TLX3 PRPH	1.50e-04	13	49	2	34728601
Pubmed	USP49 negatively regulates tumorigenesis and chemoresistance through FKBP51-AKT signaling.	AGO1 DICER1	1.50e-04	13	49	2	28363942
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	TANC2 CACNA1A ABLIM1 DZANK1 AGO1 RBMX PRRC2A SHANK3 PPP1CB	1.53e-04	1431	49	9	37142655
Pubmed	SR protein kinases promote splicing of nonconsensus introns.	MICU3 CDK13 RBMX PRRC2A PPP1CB	1.54e-04	361	49	5	26167880
Pubmed	Mammalian miRNA RISC recruits CAF1 and PABP to affect PABP-dependent deadenylation.	AGO1 DICER1	1.75e-04	14	49	2	19716330
Pubmed	Onecut factors control development of the Locus Coeruleus and of the mesencephalic trigeminal nucleus.	TLX3 PRPH	1.75e-04	14	49	2	22534286
Pubmed	A Method to Identify p62's UBA Domain Interacting Proteins.	NCOR1 ULK2	1.75e-04	14	49	2	14702098
Pubmed	Gli activity is critical at multiple stages of embryonic mammary and nipple development.	DES PRPH	1.75e-04	14	49	2	24260306
Pubmed	Enoyl-CoA hydratase-1 regulates mTOR signaling and apoptosis by sensing nutrients.	PRRC2A SIRT3	1.75e-04	14	49	2	28878358
Pubmed	Luzp4 defines a new mRNA export pathway in cancer cells.	ABLIM1 RBMX PPP1CB	2.00e-04	80	49	3	25662211
Pubmed	TRIM24 is an insulin-responsive regulator of P-bodies.	AGO1 RBMXL1 RBMX	2.00e-04	80	49	3	35803934
Pubmed	Defective glomerulogenesis in the absence of laminin alpha5 demonstrates a developmental role for the kidney glomerular basement membrane.	DES LAMA2	2.02e-04	15	49	2	10625553
Pubmed	Laminin alpha5 chain is required for intestinal smooth muscle development.	DES LAMA2	2.02e-04	15	49	2	12921739
Pubmed	Talin 1 and 2 are required for myoblast fusion, sarcomere assembly and the maintenance of myotendinous junctions.	DES LAMA2	2.02e-04	15	49	2	19793892
Pubmed	A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.	NCOR1 DZANK1 ATN1 MEGF8 TNS2 PRRC2A	2.06e-04	608	49	6	16713569
Pubmed	Tooth morphogenesis and ameloblast differentiation are regulated by micro-RNAs.	AGO1 DICER1	2.30e-04	16	49	2	20102707
Pubmed	Therapeutic targeting of the USP2-E2F4 axis inhibits autophagic machinery essential for zinc homeostasis in cancer progression.	NCOR1 EHBP1L1 TRAFD1 PPP1CB NCOA5	2.56e-04	403	49	5	35253629
Pubmed	Homeoprotein Phox2b commands a somatic-to-visceral switch in cranial sensory pathways.	TLX3 PRPH	2.61e-04	17	49	2	22128334
Pubmed	LINC00240 in the 6p22.1 risk locus promotes gastric cancer progression through USP10-mediated DDX21 stabilization.	RBMX PRRC2A	2.61e-04	17	49	2	37072811
Pubmed	Targeted deletion of Dicer in the heart leads to dilated cardiomyopathy and heart failure.	DES DICER1	2.61e-04	17	49	2	18256189
Pubmed	Nuclear heterogeneous nuclear ribonucleoprotein D is associated with poor prognosis and interactome analysis reveals its novel binding partners in oral cancer.	AGO1 RBMX PPP1CB	2.65e-04	88	49	3	26318153
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	ABLIM1 SETD1B MEGF8 BTBD7 ULK2	2.67e-04	407	49	5	12693553
Pubmed	Genome-wide expression analysis of Ptf1a- and Ascl1-deficient mice reveals new markers for distinct dorsal horn interneuron populations contributing to nociceptive reflex plasticity.	TLX3 PRPH	2.93e-04	18	49	2	23616538
Pubmed	Epithelial hedgehog signals pattern the intestinal crypt-villus axis.	DES PRPH	2.93e-04	18	49	2	15590741
Pubmed	Single nucleotide polymorphisms of microRNA machinery genes modify the risk of renal cell carcinoma.	AGO1 DICER1	2.93e-04	18	49	2	19047128
Pubmed	Comprehensive identification of phosphorylation sites in postsynaptic density preparations.	TANC2 ABLIM1 DZANK1 PRRC2A	3.18e-04	231	49	4	16452087
Pubmed	Interactome Analysis Reveals Regulator of G Protein Signaling 14 (RGS14) is a Novel Calcium/Calmodulin (Ca2+/CaM) and CaM Kinase II (CaMKII) Binding Partner.	ABLIM1 SHANK3 PPP1CB PRPH	3.28e-04	233	49	4	29518331
Pubmed	Identification of motif-based interactions between SARS-CoV-2 protein domains and human peptide ligands pinpoint antiviral targets.	CACNA1A NCOR1 AGO1 SHANK3	3.28e-04	233	49	4	37704626
Pubmed	Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.	NCOR1 ATN1 NFATC4 ARHGEF5 ZMIZ2	3.44e-04	430	49	5	35044719
Pubmed	Genetic variation in MicroRNA genes and risk of oral premalignant lesions.	AGO1 DICER1	3.64e-04	20	49	2	19851984
Pubmed	FOXK2 Elicits Massive Transcription Repression and Suppresses the Hypoxic Response and Breast Cancer Carcinogenesis.	NCOR1 SETD1B	3.64e-04	20	49	2	27773593
Pubmed	Interactome analyses revealed that the U1 snRNP machinery overlaps extensively with the RNAP II machinery and contains multiple ALS/SMA-causative proteins.	NCOR1 RBMX PRRC2A NCOA5	3.91e-04	244	49	4	29884807
Pubmed	NMRK2 Gene Is Upregulated in Dilated Cardiomyopathy and Required for Cardiac Function and NAD Levels during Aging.	LAMA2 SIRT3	4.01e-04	21	49	2	33805532
Pubmed	The transcription factor Hmx1 and growth factor receptor activities control sympathetic neurons diversification.	TLX3 PRPH	4.01e-04	21	49	2	23591430
Pubmed	Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	NCOR1 SETD1B TNS2	4.33e-04	104	49	3	10470851
Pubmed	SETD1A Methyltransferase Is Physically and Functionally Linked to the DNA Damage Repair Protein RAD18.	SETD1B RBMXL1 PPP1CB NCOA5	4.35e-04	251	49	4	31076518
Pubmed	Long-term potentiation modulates synaptic phosphorylation networks and reshapes the structure of the postsynaptic interactome.	ABLIM1 DZANK1 SHANK3 PPP1CB	4.35e-04	251	49	4	27507650
Pubmed	Brn3a/Pou4f1 regulates dorsal root ganglion sensory neuron specification and axonal projection into the spinal cord.	TLX3 PRPH	4.41e-04	22	49	2	22326227
Pubmed	A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract.	ZXDC ABLIM1 NFATC4 ZMIZ2 RORC PLXNA1	4.66e-04	709	49	6	22988430
Pubmed	Uncovering quantitative protein interaction networks for mouse PDZ domains using protein microarrays.	PRKN SHANK3	4.83e-04	23	49	2	16637659
Pubmed	The Repeat Expansion Diseases: The dark side of DNA repair.	CACNA1A ATN1	4.83e-04	23	49	2	26002199
Pubmed	Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism.	SCAP SETD1B CDK13 BTBD7 ZNF629 ULK2 DICER1 NCOA5	4.93e-04	1327	49	8	32694731
Pubmed	Genetic variations in microRNA-related genes are associated with survival and recurrence in patients with renal cell carcinoma.	AGO1 DICER1	5.26e-04	24	49	2	20732906
Pubmed	Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers.	SETD1B CEACAM21 CDK13 ULK2 PLXNA1 KCNH4	5.44e-04	730	49	6	34857952
Pubmed	Lmx1b controls the differentiation and migration of the superficial dorsal horn neurons of the spinal cord.	TLX3 PRPH	5.71e-04	25	49	2	15229182
Pubmed	Genetic variations in microRNA-related genes are novel susceptibility loci for esophageal cancer risk.	AGO1 DICER1	5.71e-04	25	49	2	19138993
Pubmed	Lineage and stage specific requirement for Dicer1 in sympathetic ganglia and adrenal medulla formation and maintenance.	TLX3 DICER1	5.71e-04	25	49	2	25661788
Interaction	TOP3B interactions	TANC2 ZXDC NCOR1 EHBP1L1 SCAP SETD1B MEGF8 CDK13 BTBD7 ZMIZ2 PRKN CTIF ULK2 PRRC2A PLXNA1 PRRT4	1.97e-07	1470	49	16	int:TOP3B
Interaction	PPP1CC interactions	TANC2 NCOR1 RBMXL1 RBMX TLX3 ZNF629 PRKN RORC SHANK3 PPP1CB NCOA5	1.20e-06	738	49	11	int:PPP1CC
Interaction	PPP1CB interactions	NCOR1 ABLIM1 RBMXL1 CDK13 RBMX PRKN RORC PPP1CB NCOA5	1.67e-06	469	49	9	int:PPP1CB
Interaction	MEGF6 interactions	CACNA1A ATN1 SHANK3	7.40e-06	16	49	3	int:MEGF6
Interaction	MEGF8 interactions	CACNA1A ATN1 MEGF8 PRKN	1.03e-05	56	49	4	int:MEGF8
Interaction	GFAP interactions	DES NCOR1 ABLIM1 NFATC4 PRKN PRPH	2.22e-05	236	49	6	int:GFAP
Interaction	RBM12B interactions	CACNA1A RBMX PRKN PPP1CB	2.37e-05	69	49	4	int:RBM12B
Interaction	SIRT2 interactions	TLX3 PRKN SHANK3 PPP1CB PRPH	4.93e-05	165	49	5	int:SIRT2
Interaction	KRT76 interactions	DES TNS2 PRKN PRPH	5.16e-05	84	49	4	int:KRT76
Interaction	PRMT2 interactions	SETD1B PRKN PRRC2A SHANK3	7.06e-05	91	49	4	int:PRMT2
Interaction	LTBP1 interactions	CACNA1A ATN1 LAMA2 PRKN	7.36e-05	92	49	4	int:LTBP1
Interaction	RERE interactions	SETD1B ATN1 TLX3 PRRC2A	7.68e-05	93	49	4	int:RERE
Interaction	KHDRBS3 interactions	CACNA1A RBMX SHANK3 NCOA5	8.01e-05	94	49	4	int:KHDRBS3
Interaction	ALG13 interactions	NCOR1 ATN1 PRKN PRRC2A NCOA5	8.06e-05	183	49	5	int:ALG13
Interaction	MEGF11 interactions	ATN1 SHANK3	8.63e-05	6	49	2	int:MEGF11
Interaction	KALRN interactions	CACNA1A DZANK1 DICER1 SHANK3	8.69e-05	96	49	4	int:KALRN
Interaction	ATN1 interactions	SETD1B ATN1 MEGF8 PRRC2A SHANK3	8.93e-05	187	49	5	int:ATN1
Interaction	LUZP4 interactions	ABLIM1 RBMX TNS2 PPP1CB	9.80e-05	99	49	4	int:LUZP4
Interaction	TMSB4Y interactions	RBMXL1 PRRC2A NCOA5	1.16e-04	39	49	3	int:TMSB4Y
Interaction	RBMX interactions	PMPCA RBMXL1 RBMX PRKN PRRC2A PPP1CB NCOA5	1.17e-04	461	49	7	int:RBMX
Interaction	TEKT3 interactions	ATN1 TNS2 PRRC2A	1.25e-04	40	49	3	int:TEKT3
Interaction	PPP1R7 interactions	RBMX PRKN SHANK3 PPP1CB	1.53e-04	111	49	4	int:PPP1R7
Interaction	CA5A interactions	PMPCA SIRT3	1.61e-04	8	49	2	int:CA5A
Interaction	USP54 interactions	ATN1 RBMXL1 TNS2 PRRC2A PRPH	1.61e-04	212	49	5	int:USP54
Interaction	PDK2 interactions	PMPCA PRKN SIRT3	1.91e-04	46	49	3	int:PDK2
Interaction	MPP2 interactions	ABLIM1 PRKN SHANK3	2.03e-04	47	49	3	int:MPP2
Interaction	NCOA5 interactions	RBMX PRKN PPP1CB NCOA5	2.13e-04	121	49	4	int:NCOA5
Cytoband	7p13	CDK13 ZMIZ2	8.06e-04	39	49	2	7p13
Cytoband	4q13.3	SMR3A SMR3B	9.35e-04	42	49	2	4q13.3
Cytoband	3q21.3	ZXDC PLXNA1	1.07e-03	45	49	2	3q21.3
Cytoband	2q35	DES RNF25	3.26e-03	79	49	2	2q35
GeneFamily	Intermediate filaments Type III	DES PRPH	3.84e-05	5	36	2	610
Coexpression	GSE21033_CTRL_VS_POLYIC_STIM_DC_6H_DN	MICU3 MEGF8 CDK13 BTBD7 DICER1	1.11e-05	157	49	5	M7733
Coexpression	CYCLIN_D1_KE_.V1_UP	ABLIM1 SCAP PMPCA PRRC2A PRPH	2.66e-05	188	49	5	M2648
Coexpression	ZHONG_PFC_C3_MICROGLIA	TANC2 CACNA1A ABLIM1 TMEM121B CTIF PLXNA1 EBF4	3.25e-05	488	49	7	M39104
Coexpression	NAKAYA_PLASMACYTOID_DENDRITIC_CELL_FLUMIST_AGE_18_50YO_7DY_DN	CACNA1A EHBP1L1 TRAFD1 MEGF8 ZMIZ2 LAMA2 SMR3A PLXNA1 SMR3B	4.12e-05	909	49	9	M41018
ToppCell	367C-Myeloid-Macrophage-FABP4+_Macrophage_3\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	NFATC4 LAMA2 SHANK3 EBF4	3.33e-05	166	49	4	f416d8a322f086c769659a9fab6b460a2d546ab1
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Mesenchymal-glomerular_mesenchymal_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CACNA1A MICU3 NFATC4 LAMA2	4.66e-05	181	49	4	a2058d658f07ab6f0a28d2622f3090b4cde6f763
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CACNA1A MICU3 NFATC4 LAMA2	4.66e-05	181	49	4	526e858a848470b6d2d5248788004d9735ed3add
ToppCell	LV-15._Ventricular_Cardiomyocyte_III\|LV / Chamber and Cluster_Paper	DES ABLIM1 LAMA2 PRKN	4.97e-05	184	49	4	ab7a1620c14a9d9b6be1b47c559931e345e9eef8
ToppCell	COVID-19-Heart-CM_2\|COVID-19 / Disease (COVID-19 only), tissue and cell type	DES ABLIM1 LAMA2 PRKN	5.07e-05	185	49	4	549eeb521c3985bff396ea0f202db21822efa51f
ToppCell	kidney_cells-Adult_normal_reference-Mesenchymal-glomerular_mesenchymal_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CACNA1A NFATC4 LAMA2 TNS2	5.29e-05	187	49	4	ac8e092b37e042975e2ee057d3f7c6821e58e8b5
ToppCell	kidney_cells-Adult_normal_reference-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell-mesangial_typical\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CACNA1A NFATC4 LAMA2 TNS2	5.29e-05	187	49	4	d591a3c216997663ab77710fed0d230ffc37e41a
ToppCell	kidney_cells-Adult_normal_reference-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CACNA1A NFATC4 LAMA2 TNS2	5.29e-05	187	49	4	d1dc8c9a2c2cd10c640257161a75e7730ec5bb41
ToppCell	Substantia_nigra-Endothelial\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	DES NFATC4 ARHGEF5 TNS2	5.51e-05	189	49	4	bef8234bd9c4d6e3cdef0791d8066b39ba56ebba
ToppCell	RV-15._Ventricular_Cardiomyocyte_III\|RV / Chamber and Cluster_Paper	ABLIM1 ZDHHC14 LAMA2 PRKN	5.63e-05	190	49	4	93c3188dfeb0b2f9889f8ae9b9c1f2f34129c99b
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	TANC2 ABLIM1 ZDHHC14 PPP1CB	5.63e-05	190	49	4	bf4511395fa97efd1c1cd17cc9bebb0271ee7f0e
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	TANC2 ABLIM1 ZDHHC14 PPP1CB	5.63e-05	190	49	4	b6b8964b4910083499681b5fdf554e127b6a4c4e
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	TANC2 ABLIM1 ZDHHC14 PPP1CB	5.74e-05	191	49	4	2fa1b9e76a0ed2d2f0de74349e266cf4a5f51aad
ToppCell	Hippocampus-Endothelial\|Hippocampus / BrainAtlas - Mouse McCarroll V32	DES NFATC4 ARHGEF5 TNS2	5.86e-05	192	49	4	36deadab892d3e639a71f33697bb2d3cbbaa5372
ToppCell	COVID-19-Heart-CM_2\|Heart / Disease (COVID-19 only), tissue and cell type	DES ABLIM1 LAMA2 PRKN	6.22e-05	195	49	4	75fc81bddb246dca3b437fb60827b1d4fe416405
Drug	Cinchonine [118-10-5]; Down 200; 13.6uM; PC3; HT_HG-U133A	DES ATN1 RNF25 SMR3A CTIF SIRT3	3.65e-06	194	49	6	3988_DN
Drug	Suramin sodium salt; Down 200; 10uM; PC3; HT_HG-U133A	ZXDC NCOR1 TRAFD1 ATN1 MEGF8 ZMIZ2	3.65e-06	194	49	6	7529_DN
Drug	Metoclopramide monohydrochloride [7232-21-5]; Down 200; 11.8uM; MCF7; HT_HG-U133A	CACNA1A EHBP1L1 ATN1 BTBD7 DICER1 SIRT3	3.65e-06	194	49	6	3625_DN
Drug	Furaltadone hydrochloride [3759-92-0]; Up 200; 11uM; MCF7; HT_HG-U133A	DES DZANK1 ATN1 CEACAM21 AP5Z1 CTIF	3.65e-06	194	49	6	3838_UP
Drug	Tiletamine hydrochloride; Down 200; 15.4uM; HL60; HT_HG-U133A	CACNA1A CDK13 ZDHHC14 SMR3A ULK2 SIRT3	3.76e-06	195	49	6	3137_DN
Drug	Butamben [94-25-7]; Down 200; 20.6uM; HL60; HT_HG-U133A	CACNA1A MEGF8 BTBD7 RNF25 SMR3A ULK2	3.87e-06	196	49	6	2531_DN
Drug	Vincamine [1617-90-9]; Down 200; 11.2uM; HL60; HT_HG-U133A	NCOR1 AP5Z1 ZDHHC14 SMR3A DICER1 PLXNA1	3.87e-06	196	49	6	2367_DN
Drug	Acacetin [480-44-4]; Up 200; 14uM; MCF7; HT_HG-U133A	ATN1 NFATC4 ZMIZ2 TNS2 CTIF PRRC2A	3.87e-06	196	49	6	3849_UP
Drug	Epitiostanol [2363-58-8]; Down 200; 13uM; MCF7; HT_HG-U133A	TANC2 EHBP1L1 TRAFD1 BTBD7 TNS2 SIRT3	4.11e-06	198	49	6	4788_DN
Drug	Nitrofurantoin [67-20-9]; Up 200; 16.8uM; PC3; HT_HG-U133A	CACNA1A EHBP1L1 ZMIZ2 CTIF ULK2 SIRT3	4.11e-06	198	49	6	7373_UP
Drug	Dantrolene sodium salt [14663-23-1]; Up 200; 11.8uM; MCF7; HT_HG-U133A	CACNA1A TRAFD1 CDK13 ZDHHC14 PRKN RORC	4.23e-06	199	49	6	2329_UP
Drug	Ethionamide [536-33-4]; Down 200; 24uM; PC3; HT_HG-U133A	ZXDC CACNA1A MEGF8 CDK13 AP5Z1 ZMIZ2	4.23e-06	199	49	6	4593_DN
Drug	aspirin, USP; Down 200; 100uM; HL60; HT_HG-U133A	CACNA1A MEGF8 BTBD7 AP5Z1 TNS2 CTIF	4.35e-06	200	49	6	2664_DN
Drug	radicicol; Down 200; 0.1uM; MCF7; HT_HG-U133A_EA	ZXDC EHBP1L1 ZMIZ2 ULK2 PRRC2A	5.44e-05	190	49	5	836_DN
Drug	Luteolin [491-70-3]; Down 200; 14uM; MCF7; HT_HG-U133A	ZXDC TRAFD1 BTBD7 TNS2 ULK2	5.44e-05	190	49	5	3379_DN
Drug	Beta-Escin [11072-93-8]; Down 200; 3.2uM; MCF7; HT_HG-U133A	DZANK1 EHBP1L1 ATN1 ZMIZ2 PLXNA1	5.57e-05	191	49	5	3890_DN
Drug	pioglitazone HCl; Down 200; 10uM; PC3; HT_HG-U133A	TANC2 CACNA1A CDK13 ULK2 SIRT3	5.71e-05	192	49	5	5930_DN
Drug	Muramic acid, N-acetyl [10597-89-4]; Up 200; 13.6uM; MCF7; HT_HG-U133A	CACNA1A NCOR1 SCAP ATN1 PRRC2A	5.85e-05	193	49	5	3262_UP
Drug	Theobromine [83-67-0]; Down 200; 22.2uM; PC3; HT_HG-U133A	CACNA1A ZMIZ2 CTIF ULK2 SIRT3	5.85e-05	193	49	5	6613_DN
Drug	CP-690334-01 [459212-38-5]; Down 200; 10uM; MCF7; HT_HG-U133A	TANC2 ABLIM1 CDK13 AP5Z1 TNS2	5.85e-05	193	49	5	3906_DN
Drug	Mexiletine hydrochloride [5370-01-4]; Down 200; 18.6uM; MCF7; HT_HG-U133A	CACNA1A DES ZMIZ2 ZDHHC14 ULK2	5.85e-05	193	49	5	3973_DN
Drug	ICI182,780; Down 200; 1uM; MCF7; HT_HG-U133A	TRAFD1 MEGF8 ZMIZ2 ZDHHC14 CTIF	6.00e-05	194	49	5	7534_DN
Drug	chlorpromazine hydrochloride; Down 200; 1uM; PC3; HT_HG-U133A	TANC2 NCOR1 ZDHHC14 PRRC2A PRPH	6.00e-05	194	49	5	1217_DN
Drug	Aconitine [302-27-2]; Up 200; 6.2uM; MCF7; HT_HG-U133A	DES MEGF8 AP5Z1 ZMIZ2 LAMA2	6.00e-05	194	49	5	2776_UP
Drug	Tetrandrine [518-34-3]; Down 200; 6.4uM; HL60; HT_HG-U133A	TRAFD1 BTBD7 TNS2 CTIF PLXNA1	6.00e-05	194	49	5	2520_DN
Drug	NU1025; Up 200; 100uM; MCF7; HG-U133A	TANC2 TRAFD1 CEACAM21 LAMA2 CTIF	6.00e-05	194	49	5	608_UP
Drug	Trichostatin A, Streptomyces sp.; Down 200; 0.1uM; HL60; HT_HG-U133A	CACNA1A DES ZMIZ2 RNF25 CTIF	6.00e-05	194	49	5	2672_DN
Drug	Sulfamethazine sodium salt [1981-58-4]; Up 200; 13.4uM; MCF7; HT_HG-U133A	CDK13 BTBD7 ZDHHC14 SMR3A ULK2	6.00e-05	194	49	5	3422_UP
Drug	Mebendazole [31431-39-7]; Down 200; 13.6uM; PC3; HT_HG-U133A	TANC2 ATN1 CDK13 ZMIZ2 SIRT3	6.00e-05	194	49	5	3671_DN
Drug	ICI 182,780; Up 200; 1uM; MCF7; HT_HG-U133A	TANC2 EHBP1L1 TRAFD1 ATN1 AP5Z1	6.15e-05	195	49	5	1630_UP
Drug	Meptazinol hydrochloride [59263-76-2]; Up 200; 14.8uM; MCF7; HT_HG-U133A	DES NCOR1 AP5Z1 SMR3A DICER1	6.15e-05	195	49	5	7326_UP
Drug	PNU-0230031 [267429-39-0]; Down 200; 1uM; PC3; HT_HG-U133A	CACNA1A CDK13 ZMIZ2 CTIF SIRT3	6.15e-05	195	49	5	3735_DN
Drug	Fillalbin [4540-25-4]; Down 200; 13.8uM; MCF7; HT_HG-U133A	EHBP1L1 ATN1 BTBD7 TNS2 PRPH	6.15e-05	195	49	5	2813_DN
Drug	Tadjakonine [11087-94-8]; Down 200; 7.4uM; MCF7; HT_HG-U133A	DZANK1 AP5Z1 ZDHHC14 ULK2 PRPH	6.15e-05	195	49	5	2820_DN
Drug	Bromopride [4093-35-0]; Down 200; 11.6uM; PC3; HT_HG-U133A	CACNA1A EHBP1L1 ATN1 ZMIZ2 RNF25	6.15e-05	195	49	5	3719_DN
Drug	troglitazone; Down 200; 10uM; HL60; HT_HG-U133A	DZANK1 TRAFD1 MEGF8 RNF25 ZDHHC14	6.15e-05	195	49	5	6191_DN
Drug	Glibenclamide [10238-21-8]; Up 200; 8uM; HL60; HG-U133A	CACNA1A ZMIZ2 LAMA2 CTIF PLXNA1	6.30e-05	196	49	5	1546_UP
Drug	GSK-3 Inhibitor IX; Up 200; 0.5uM; PC3; HT_HG-U133A	TANC2 NFATC4 CDK13 AP5Z1 ZMIZ2	6.30e-05	196	49	5	6559_UP
Drug	estradiol, USP; Down 200; 0.01uM; MCF7; HT_HG-U133A_EA	TANC2 EHBP1L1 ZMIZ2 TNS2 ULK2	6.30e-05	196	49	5	1021_DN
Drug	alpha-estradiol; Up 200; 0.01uM; HL60; HT_HG-U133A	TANC2 BTBD7 ZMIZ2 SMR3A SMR3B	6.30e-05	196	49	5	2670_UP
Drug	Indapamide [26807-65-8]; Down 200; 10.6uM; HL60; HT_HG-U133A	NCOR1 BTBD7 SMR3A PLXNA1 SIRT3	6.30e-05	196	49	5	2361_DN
Drug	Lobeline alpha (-) hydrochoride [134-63-4]; Up 200; 10.6uM; HL60; HG-U133A	CACNA1A ATN1 LAMA2 RORC CTIF	6.30e-05	196	49	5	1770_UP
Drug	Chlorzoxazone [95-25-0]; Up 200; 23.6uM; HL60; HG-U133A	CACNA1A ATN1 ZMIZ2 LAMA2 CTIF	6.30e-05	196	49	5	1416_UP
Drug	R(+)-verapamil hydrochloride; Up 200; 10uM; MCF7; HG-U133A	ZMIZ2 TNS2 CTIF PLXNA1 SIRT3	6.30e-05	196	49	5	164_UP
Drug	topiramate; Down 200; 3uM; MCF7; HT_HG-U133A_EA	EHBP1L1 AGO1 ATN1 ZMIZ2 PRPH	6.30e-05	196	49	5	915_DN
Drug	haloperidol; Up 200; 10uM; MCF7; HT_HG-U133A	TANC2 ATN1 BTBD7 ZMIZ2 ULK2	6.30e-05	196	49	5	6923_UP
Drug	DNA-PK Inhibitor III; Down 200; 1uM; MCF7; HT_HG-U133A	TANC2 ATN1 AP5Z1 RNF25 ZDHHC14	6.30e-05	196	49	5	7513_DN
Drug	Flumequine [42835-25-6]; Up 200; 15.4uM; MCF7; HT_HG-U133A	NFATC4 CDK13 ZMIZ2 SMR3A CTIF	6.45e-05	197	49	5	2276_UP
Drug	PF-00875133-00 [351322-64-0]; Down 200; 10uM; MCF7; HT_HG-U133A	DES TRAFD1 ATN1 CDK13 ZMIZ2	6.45e-05	197	49	5	5923_DN
Drug	Ciprofibrate [52214-84-3]; Down 200; 13.8uM; HL60; HT_HG-U133A	DES MEGF8 TNS2 ULK2 SIRT3	6.45e-05	197	49	5	6138_DN
Drug	Terconazole [67915-31-5]; Down 200; 7.6uM; PC3; HT_HG-U133A	CACNA1A MEGF8 ZMIZ2 CTIF SIRT3	6.45e-05	197	49	5	4583_DN
Drug	Glycopyrrolate [596-51-0]; Down 200; 10uM; MCF7; HT_HG-U133A	DZANK1 EHBP1L1 TRAFD1 ATN1 ZMIZ2	6.45e-05	197	49	5	4709_DN
Drug	NS-398; Down 200; 10uM; MCF7; HT_HG-U133A	DZANK1 EHBP1L1 AP5Z1 ZMIZ2 ZDHHC14	6.45e-05	197	49	5	6897_DN
Drug	Benzocaine [94-09-7]; Down 200; 24.2uM; MCF7; HT_HG-U133A	EHBP1L1 AP5Z1 ZMIZ2 ZDHHC14 PLXNA1	6.45e-05	197	49	5	2822_DN
Drug	Bupivacaine hydrochloride [18010-40-7]; Up 200; 12.4uM; MCF7; HT_HG-U133A	DES ATN1 AP5Z1 ZMIZ2 DICER1	6.45e-05	197	49	5	5537_UP
Drug	Ethynylestradiol 3-methyl ether [72-33-3]; Up 200; 12.8uM; HL60; HT_HG-U133A	DES TRAFD1 ATN1 ZMIZ2 ULK2	6.45e-05	197	49	5	3008_UP
Drug	Trioxsalen [3902-71-4]; Up 200; 17.6uM; MCF7; HT_HG-U133A	CACNA1A SMR3A ULK2 SIRT3 PRPH	6.61e-05	198	49	5	6216_UP
Drug	Chlortetracycline hydrochloride [64-72-2]; Up 200; 7.8uM; MCF7; HT_HG-U133A	DES ATN1 ZMIZ2 PRRC2A PRPH	6.61e-05	198	49	5	1541_UP
Drug	Novobiocin sodium salt [1476-53-5]; Down 200; 6.4uM; PC3; HT_HG-U133A	ATN1 MEGF8 CDK13 AP5Z1 ZMIZ2	6.61e-05	198	49	5	4569_DN
Drug	Biperiden hydrochloride [1235-82-1]; Up 200; 11.4uM; MCF7; HT_HG-U133A	DES CDK13 ZMIZ2 SMR3A CTIF	6.61e-05	198	49	5	5644_UP
Drug	Cefaclor [70356-03-5]; Down 200; 10.4uM; PC3; HT_HG-U133A	ZXDC CACNA1A CDK13 SMR3A ULK2	6.61e-05	198	49	5	6622_DN
Drug	Methotrimeprazine maleat salt [7104-38-3]; Down 200; 9uM; MCF7; HT_HG-U133A	TRAFD1 BTBD7 PLXNA1 SIRT3 PRPH	6.61e-05	198	49	5	3440_DN
Drug	Eserine sulfate, physostigmine sulfate [64-47-1]; Up 200; 6.2uM; MCF7; HT_HG-U133A	CACNA1A TRAFD1 CDK13 BTBD7 SMR3A	6.61e-05	198	49	5	6226_UP
Drug	Ranitidine hydrochloride [66357-59-3]; Up 200; 11.4uM; MCF7; HT_HG-U133A	ATN1 AP5Z1 ZMIZ2 CTIF PLXNA1	6.61e-05	198	49	5	5425_UP
Drug	cis-4,7,10,13,16,19-Docosahexaenoic acid ethyl ester; Down 200; 100uM; MCF7; HT_HG-U133A_EA	EHBP1L1 TRAFD1 AGO1 ZMIZ2 DICER1	6.61e-05	198	49	5	881_DN
Drug	CP-863187 [668981-07-5]; Up 200; 10uM; MCF7; HT_HG-U133A	ABLIM1 EHBP1L1 ZMIZ2 RNF25 PRPH	6.61e-05	198	49	5	7553_UP
Drug	Ricinine [524-40-3]; Up 200; 24.4uM; MCF7; HT_HG-U133A	DES EHBP1L1 BTBD7 CTIF SIRT3	6.61e-05	198	49	5	6206_UP
Drug	Cyclacillin [3485-14-1]; Down 200; 11.8uM; MCF7; HT_HG-U133A	ATN1 CDK13 BTBD7 TNS2 CTIF	6.61e-05	198	49	5	3882_DN
Drug	Piperine [94-62-2]; Up 200; 14uM; MCF7; HT_HG-U133A	DES ATN1 CDK13 LAMA2 CTIF	6.61e-05	198	49	5	4830_UP
Drug	Heptaminol hydrochloride [543-15-7]; Down 200; 22uM; PC3; HT_HG-U133A	ABLIM1 TRAFD1 AP5Z1 ZMIZ2 RNF25	6.61e-05	198	49	5	1825_DN
Drug	Galanthamine hydrobromide [1953-04-4]; Up 200; 10.8uM; MCF7; HT_HG-U133A	CACNA1A DES CDK13 SMR3A SIRT3	6.77e-05	199	49	5	2787_UP
Drug	Eucatropine hydrochloride [536-93-6]; Up 200; 12.2uM; MCF7; HT_HG-U133A	CACNA1A ATN1 AP5Z1 ZMIZ2 CTIF	6.77e-05	199	49	5	3841_UP
Drug	Gibberellic acid [77-06-5]; Down 200; 11.6uM; MCF7; HT_HG-U133A	NCOR1 CDK13 RNF25 SIRT3 PRPH	6.77e-05	199	49	5	7330_DN
Drug	Furosemide [54-31-9]; Up 200; 12uM; MCF7; HT_HG-U133A	EHBP1L1 ATN1 AP5Z1 ZMIZ2 TLX3	6.77e-05	199	49	5	6841_UP
Drug	Fenspiride hydrochloride [5053-08-7]; Up 200; 13.4uM; PC3; HT_HG-U133A	CACNA1A CDK13 TLX3 SMR3A PRPH	6.77e-05	199	49	5	7298_UP
Drug	Levamisole hydrochloride [16595-80-5]; Up 200; 16.6uM; MCF7; HT_HG-U133A	CACNA1A DZANK1 CDK13 TNS2 SIRT3	6.77e-05	199	49	5	7450_UP
Drug	Austricine [10180-88-8]; Up 200; 14.2uM; PC3; HT_HG-U133A	CACNA1A DES CDK13 ZMIZ2 PRPH	6.77e-05	199	49	5	4213_UP
Drug	Diphenylpyraline hydrochloride [132-18-3]; Up 200; 12.6uM; MCF7; HT_HG-U133A	DES CEACAM21 ZMIZ2 RORC CTIF	6.77e-05	199	49	5	3640_UP
Drug	Oxalamine citrate salt [1949-20-8]; Down 200; 9.2uM; PC3; HT_HG-U133A	CACNA1A CDK13 ZMIZ2 CTIF ULK2	6.77e-05	199	49	5	6624_DN
Drug	Karakoline [39089-30-0]; Down 200; 10.6uM; PC3; HT_HG-U133A	CACNA1A ATN1 BTBD7 ZMIZ2 TNS2	6.77e-05	199	49	5	4297_DN
Drug	Arcaine sulfate [14923-17-2]; Down 200; 14.8uM; HL60; HT_HG-U133A	TANC2 DES DZANK1 BTBD7 ZMIZ2	6.93e-05	200	49	5	3010_DN
Drug	ICI 182,780; Down 200; 1uM; HL60; HT_HG-U133A	CACNA1A DZANK1 SMR3A TNS2 CTIF	6.93e-05	200	49	5	2665_DN
Drug	Epivincamine [6835-99-0]; Up 200; 11.2uM; MCF7; HT_HG-U133A	CACNA1A CDK13 AP5Z1 CTIF ULK2	6.93e-05	200	49	5	6838_UP
Drug	C-cluster	DES ATN1 KCNH4 PRPH	2.28e-04	139	49	4	CID000446537
Drug	isovalerate	CACNA1A EHBP1L1 DICER1 NCOA5	2.54e-04	143	49	4	CID000010430
Drug	ethanolamine-O-sulfate	CACNA1A ATN1 CDK13	3.09e-04	61	49	3	CID000070223
Drug	7,8-diaminopelargonic acid	NCOR1 ATN1	4.06e-04	14	49	2	CID000000652
Drug	3-acetylpyridine	CACNA1A ATN1 PRPH	5.67e-04	75	49	3	CID000009589
Drug	Trichostatin A, from Streptomyces sp.; Up 200; 0.1uM; MCF7; HT_HG-U133A	DZANK1 EHBP1L1 TRAFD1 PRPH	6.19e-04	181	49	4	7453_UP
Drug	Sparteine (-) [90-39-1]; Down 200; 17uM; MCF7; HT_HG-U133A	ABLIM1 EHBP1L1 BTBD7 TNS2	7.28e-04	189	49	4	2790_DN
Drug	Cyclosporin A [59865-13-3]; Up 200; 3.4uM; HL60; HT_HG-U133A	MEGF8 AP5Z1 ZDHHC14 PLXNA1	7.28e-04	189	49	4	1331_UP
Drug	Fenoprofen calcium salt dihydrate [53746-45-5]; Up 200; 7.2uM; PC3; HT_HG-U133A	ATN1 MEGF8 CDK13 CTIF	7.42e-04	190	49	4	4274_UP
Drug	Dienestrol [84-17-3]; Up 200; 15uM; MCF7; HT_HG-U133A	CDK13 BTBD7 ZDHHC14 CTIF	7.57e-04	191	49	4	3448_UP
Drug	Prochlorperazine dimaleate [84-02-6]; Down 200; 6.6uM; HL60; HT_HG-U133A	DZANK1 EHBP1L1 TRAFD1 PRRC2A	7.72e-04	192	49	4	1286_DN
Drug	0317956-0000 [391210-11-0]; Up 200; 1uM; MCF7; HT_HG-U133A	SETD1B CDK13 CTIF ULK2	7.72e-04	192	49	4	3858_UP
Drug	15(S)-15-methyl Prostaglandin E2; Up 200; 10uM; PC3; HT_HG-U133A	BTBD7 ZMIZ2 ZDHHC14 SIRT3	7.72e-04	192	49	4	7526_UP
Drug	Eburnamonine (-) [4880-88-0]; Down 200; 13.6uM; MCF7; HT_HG-U133A	TRAFD1 CDK13 SMR3A TNS2	7.87e-04	193	49	4	6802_DN
Drug	Tolazamide [1156-19-0]; Up 200; 12.8uM; HL60; HT_HG-U133A	TANC2 ZMIZ2 SIRT3 PRPH	7.87e-04	193	49	4	2482_UP
Drug	Alverine citrate salt [5560-59-8]; Down 200; 8.4uM; PC3; HT_HG-U133A	ZXDC DZANK1 ZDHHC14 SIRT3	7.87e-04	193	49	4	6345_DN
Drug	Canrenoic acid potassium salt [2181-04-6]; Down 200; 10uM; MCF7; HT_HG-U133A	SMR3A TNS2 PPP1CB PRPH	7.87e-04	193	49	4	6783_DN
Disease	major depressive episode	SETD1B RBMX PRKN	5.48e-05	47	46	3	EFO_0007634
Disease	Generalized hypotonia	AGO1 ATN1	2.46e-04	15	46	2	C1858120
Disease	major depressive episode, major depressive disorder	SETD1B RBMX	1.37e-03	35	46	2	EFO_0007634, MONDO_0002009

Protein segments in the cluster

Peptide	Gene	Start	Entry
GRAATSGPRRYPGPT	CACNA1A	2331	O00555
SYQGGSAPHPSGRPT	CTIF	226	O43310
IYSRPGSSIPGSPGH	ABLIM1	356	O14639
AALYGFPSTGTSPPR	ARHGEF5	576	Q12774
PGPAYSGRETISPSG	CEACAM21	91	Q3KPI0
SPPSFRTGTPPGYRG	ATN1	661	P54259
RTGTPPGYRGTSPPA	ATN1	666	P54259
RYTPVGRSFFSPPEG	AGO1	171	Q9UL18
SGGFFSTPRARQPGP	AP5Z1	196	O43299
PSIGYSSRTLGPNPG	DICER1	1281	Q9UPY3
PSPAGGGSSPYSRRL	CDK13	341	Q14004
ESYGNSRSAPPTRGP	RBMX	286	P38159
PTRGPPPSYGGSSRY	RBMX	296	P38159
PRAGGGSQPPFRTFS	PLXNA1	31	Q9UIW2
PTFYRVSPSRGPLSG	PLXNA1	961	Q9UIW2
GFSSTSYRRTFGPPP	PRPH	11	P41219
SYRRTFGPPPSLSPG	PRPH	16	P41219
SRPSPTRRDPYGFGD	NCOA5	6	Q9HCD5
GAGTYRVGSAQPSPP	EHBP1L1	1156	Q8N3D4
GTPEGRAAPPSGRYS	MEGF8	501	Q7Z7M0
PYVNGSVGGPSRRSA	KCNH4	411	Q9UQ05
PGFYRLRSQPGGRTP	LAMA2	1396	P24043
YGDPRAGSPATGRPS	MICU3	86	Q86XE3
YGGLNSGRPVTPPRT	PPP1CB	306	P62140
PRGFAPSPGSQQSGY	EBF4	461	Q9BQW3
VSSYRRTFGGAPGFP	DES	11	P17661
SRRTPSPSQGGYFGP	BTBD7	961	Q9P203
AYGGGSGSRPPTRQS	DZANK1	166	Q9NVP4
RGTPGRGSSPASPVY	SCAP	1046	Q12770
GPPAYRRFSSGGAYP	PMPCA	26	Q10713
SRSAPLTRGPPPSYG	RBMXL1	291	Q96E39
LTRGPPPSYGGSSRY	RBMXL1	296	Q96E39
SPPAGSPAGRSIYNS	PRKN	131	O60260
VPSFSPGPSGRYGAS	TRAFD1	526	O14545
SPSRARGGYGAPPSA	TMEM121B	526	Q9BXQ6
PFPSDPYGGRGSSFS	NFATC4	786	Q14934
GRPGSHGYVRSPSPS	NCOR1	1746	O75376
SGGFRPGTPSLHPYR	PRRC2A	1861	P48634
CFTPGESQRGPRGPY	SMR3B	16	P02814
PSGIPDFRSPGSGLY	SIRT3	151	Q9NTG7
GGYPSEPTRSRTTPF	TANC2	1831	Q9HCD6
PYRGPFSLSNSGPGR	SETD1B	816	Q9UPS6
FYSPPPGGSFSGIKR	nan	36	Q8TAT8
PRRAPQASGPSTPGY	ZXDC	161	Q2QGD7
QGPDSYGSPSFRSTP	RORC	246	P51449
GGGASYSVRPSGRYP	SHANK3	1556	Q9BYB0
RTPGSSYPRLPRGQG	RNF25	426	Q96BH1
CFTPGESQRGPRGPY	SMR3A	16	Q99954
SGPSDGPTAPYQPRR	PRRT4	136	C9JH25
RPGATYPSLPASFAG	TLX3	51	O43711
DIANGTSSGGYRPPP	ZDHHC14	136	Q8IZN3
SQPGLSGPTRSIPGY	ZMIZ2	351	Q8NF64
GAGYSYSPQPSRPGS	ULK2	556	Q8IYT8
SPRLPFRGNSYPGAA	ZNF629	616	Q9UEG4
RGYPSPGAHSPRAGS	TNS2	816	Q63HR2