Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	ubiquitin-like ligase-substrate adaptor activity	PRAMEF33 DCAF13 PRAMEF10 PRAMEF17 PRAMEF18 BTRC	1.76e-06	82	89	6	GO:1990756
GeneOntologyMolecularFunction	enzyme-substrate adaptor activity	PRAMEF33 DCAF13 PRAMEF10 PRAMEF17 PRAMEF18 BTRC	4.18e-06	95	89	6	GO:0140767
GeneOntologyMolecularFunction	nuclear retinoic acid receptor binding	ASXL1 PRAMEF33 PRAMEF10 PRAMEF17 PRAMEF18	4.58e-06	55	89	5	GO:0042974
GeneOntologyMolecularFunction	nuclear receptor binding	ASXL1 PRAMEF33 DCAF13 PRAMEF10 PRAMEF17 PRAMEF18	1.90e-04	187	89	6	GO:0016922
GeneOntologyCellularComponent	cullin-RING ubiquitin ligase complex	PRAMEF33 DCAF13 PRAMEF10 SPOP PRAMEF17 PRAMEF18 BTRC	3.93e-05	212	91	7	GO:0031461
GeneOntologyCellularComponent	Cul2-RING ubiquitin ligase complex	PRAMEF33 PRAMEF10 PRAMEF17 PRAMEF18	5.19e-05	47	91	4	GO:0031462
GeneOntologyCellularComponent	ubiquitin ligase complex	AMFR PRAMEF33 DCAF13 PRAMEF10 SPOP PRAMEF17 PRAMEF18 BTRC	1.51e-04	352	91	8	GO:0000151
Domain	Sushi	SRPX CR1L CSMD3 SVEP1 GABBR1	4.27e-06	52	87	5	PF00084
Domain	CCP	SRPX CR1L CSMD3 SVEP1 GABBR1	5.16e-06	54	87	5	SM00032
Domain	SUSHI	SRPX CR1L CSMD3 SVEP1 GABBR1	6.19e-06	56	87	5	PS50923
Domain	Sushi_SCR_CCP_dom	SRPX CR1L CSMD3 SVEP1 GABBR1	6.76e-06	57	87	5	IPR000436
Domain	HYR	SRPX SVEP1	6.42e-05	3	87	2	PS50825
Domain	HYR	SRPX SVEP1	6.42e-05	3	87	2	PF02494
Domain	HYR_dom	SRPX SVEP1	6.42e-05	3	87	2	IPR003410
Domain	PRAME_family	PRAMEF10 PRAMEF17 PRAMEF18	8.96e-05	19	87	3	IPR026271
Domain	WD40_repeat_dom	WDR91 DCAF13 WDR36 ARHGEF10 WDR25 BTRC	2.64e-03	297	87	6	IPR017986
Domain	Pkinase_Tyr	CSK PDGFRB MAP3K13 PTK7	3.11e-03	129	87	4	PF07714
Domain	VWC_out	NELL1 OTOG	3.48e-03	19	87	2	SM00215
Domain	Ser-Thr/Tyr_kinase_cat_dom	CSK PDGFRB MAP3K13 PTK7	3.95e-03	138	87	4	IPR001245
Domain	-	WDR91 DCAF13 WDR36 ARHGEF10 WDR25 BTRC	4.62e-03	333	87	6	2.130.10.10
Domain	WD40/YVTN_repeat-like_dom	WDR91 DCAF13 WDR36 ARHGEF10 WDR25 BTRC	4.76e-03	335	87	6	IPR015943
Domain	EGF_3	NELL1 C9 F10 SVEP1 OTOG	4.84e-03	235	87	5	PS50026
Pubmed	Preferentially Expressed Antigen in Melanoma (PRAME) and the PRAME Family of Leucine-Rich Repeat Proteins.	PRAMEF33 PRAMEF10 PRAMEF17 PRAMEF18	2.15e-07	20	92	4	26694250
Pubmed	DUX is a non-essential synchronizer of zygotic genome activation.	PRAMEF33 PRAMEF10 SPOP PRAMEF17 PRAMEF18	2.24e-07	50	92	5	31806660
Pubmed	Sertoli cell-only phenotype and scRNA-seq define PRAMEF12 as a factor essential for spermatogenesis in mice.	PRAMEF33 PRAMEF10 PRAMEF17 PRAMEF18	3.23e-07	22	92	4	31729367
Pubmed	MAGE-B4, a binding partner of PRAMEF12, is dispensable for spermatogenesis and male fertility in mice.	PRAMEF33 PRAMEF10 PRAMEF17 PRAMEF18	5.56e-07	25	92	4	37451217
Pubmed	Differences in gene expression between mouse and human for dynamically regulated genes in early embryo.	PRAMEF33 PRAMEF10 PRAMEF17 PRAMEF18	8.94e-07	28	92	4	25089626
Pubmed	Thirteen Ovary-Enriched Genes Are Individually Not Essential for Female Fertility in Mice.	PRAMEF33 PRAMEF10 PRAMEF17 PRAMEF18	1.19e-06	30	92	4	38786026
Pubmed	Retinoic acid receptors are required for skeletal growth, matrix homeostasis and growth plate function in postnatal mouse.	PRAMEF33 PRAMEF10 PRAMEF17 PRAMEF18	2.25e-06	35	92	4	19389355
Pubmed	A hypomorphic allele of Tsc2 highlights the role of TSC1/TSC2 in signaling to AKT and models mild human TSC2 alleles.	PDGFRB MKI67 TSC1	5.03e-06	13	92	3	19357198
Pubmed	Mbd3, a component of the NuRD co-repressor complex, is required for development of pluripotent cells.	PRAMEF10 MKI67 PRAMEF17 PRAMEF18	6.87e-06	46	92	4	17287250
Pubmed	Lentiviral Vector-Mediated Complementation Restored Fetal Viability but Not Placental Hyperplasia in Plac1-Deficient Mice.	PLAC1 MKI67	6.92e-06	2	92	2	26586843
Pubmed	Differential expression of PRAMEL1, a cancer/testis antigen, during spermatogenesis in the mouse.	PRAMEF10 PRAMEF17 PRAMEF18	1.19e-05	17	92	3	23565261
Pubmed	Mouse Pramel1 regulates spermatogonial development by inhibiting retinoic acid signaling during spermatogenesis.	PRAMEF10 PRAMEF17 PRAMEF18	1.19e-05	17	92	3	37781892
Pubmed	The promoter of the oocyte-specific gene, Oog1, functions in both male and female meiotic germ cells in transgenic mice.	PRAMEF10 PRAMEF17 PRAMEF18	1.42e-05	18	92	3	23894331
Pubmed	Pramel15 facilitates zygotic nuclear DNMT1 degradation and DNA demethylation.	PRAMEF10 PRAMEF17 PRAMEF18	1.42e-05	18	92	3	39181896
Pubmed	Oogenesin is a novel mouse protein expressed in oocytes and early cleavage-stage embryos.	PRAMEF10 PRAMEF17 PRAMEF18	1.42e-05	18	92	3	12890732
Pubmed	Oocyte-specific gene Oog1 suppresses the expression of spermatogenesis-specific genes in oocytes.	PRAMEF10 PRAMEF17 PRAMEF18	1.42e-05	18	92	3	29731491
Pubmed	Identification of a new expanding family of genes characterized by atypical LRR domains. Localization of a cluster preferentially expressed in oocyte.	PRAMEF10 PRAMEF17 PRAMEF18	1.42e-05	18	92	3	14675769
Pubmed	Pramel7 mediates ground-state pluripotency through proteasomal-epigenetic combined pathways.	PRAMEF10 PRAMEF17 PRAMEF18	1.68e-05	19	92	3	28604677
Pubmed	Tsc1 deficiency-mediated mTOR hyperactivation in vascular endothelial cells causes angiogenesis defects and embryonic lethality.	MKI67 TSC1 VCAM1	1.68e-05	19	92	3	24129405
Pubmed	Oog1, an oocyte-specific protein, interacts with Ras and Ras-signaling proteins during early embryogenesis.	PRAMEF10 PRAMEF17 PRAMEF18	1.98e-05	20	92	3	16580637
Pubmed	Pramel7 mediates LIF/STAT3-dependent self-renewal in embryonic stem cells.	PRAMEF10 PRAMEF17 PRAMEF18	1.98e-05	20	92	3	21425410
Pubmed	Pathological RANK signaling in B cells drives autoimmunity and chronic lymphocytic leukemia.	CD19 TNFRSF11A	2.07e-05	3	92	2	33075129
Pubmed	Myoglobin induces vascular cell adhesion molecule-1 expression through c-Src kinase-activator protein-1/nuclear factor-kappaB pathways.	CSK VCAM1	2.07e-05	3	92	2	19887846
Pubmed	TSC1 Promotes B Cell Maturation but Is Dispensable for Germinal Center Formation.	CD19 TSC1	2.07e-05	3	92	2	26000908
Pubmed	Direct activation of mTOR in B lymphocytes confers impairment in B-cell maturation andloss of marginal zone B cells.	CD19 TSC1	2.07e-05	3	92	2	21674478
Pubmed	FBXW8 regulates G1 and S phases of cell cycle progression by restricting β-TrCP1 function.	CDC25A BTRC	2.07e-05	3	92	2	33742524
Pubmed	Identification and functional characterization of imatinib-sensitive DTD1-PDGFRB and CCDC88C-PDGFRB fusion genes in eosinophilia-associated myeloid/lymphoid neoplasms.	CCDC88C PDGFRB	2.07e-05	3	92	2	24772479
Pubmed	Adaptor protein Lnk binds to PDGF receptor and inhibits PDGF-dependent signaling.	SH2B3 PDGFRB	2.07e-05	3	92	2	21310211
Pubmed	Casein kinase 1 functions as both penultimate and ultimate kinase in regulating Cdc25A destruction.	CDC25A BTRC	2.07e-05	3	92	2	20348946
Pubmed	Receptor activator of NF-kappaB (RANK) cytoplasmic motif, 369PFQEP373, plays a predominant role in osteoclast survival in part by activating Akt/PKB and its downstream effector AFX/FOXO4.	FOXO4 TNFRSF11A	2.07e-05	3	92	2	16260781
Pubmed	CTLA4, SH2B3, and CLEC16A diversely affect the progression of early islet autoimmunity in relatives of Type 1 diabetes patients.	SH2B3 CLEC16A	2.07e-05	3	92	2	36622793
Pubmed	Cell-cell adhesion through N-cadherin enhances VCAM-1 expression via PDGFRβ in a ligand-independent manner in mesenchymal stem cells.	PDGFRB VCAM1	2.07e-05	3	92	2	24378362
Pubmed	Oogenesis specific genes (Nobox, Oct4, Bmp15, Gdf9, Oogenesin1 and Oogenesin2) are differentially expressed during natural and gonadotropin-induced mouse follicular development.	PRAMEF10 PRAMEF17 PRAMEF18	3.05e-05	23	92	3	19480014
Pubmed	Incomplete reactivation of Oct4-related genes in mouse embryos cloned from somatic nuclei.	PRAMEF10 PRAMEF17 PRAMEF18	3.95e-05	25	92	3	12620990
Pubmed	IL-17-dependent fibroblastic reticular cell training boosts tissue protective mucosal immunity through IL-10-producing B cells.	CD19 IL17RA	4.14e-05	4	92	2	34919443
Pubmed	Regulation of lung cancer cell growth and invasiveness by beta-TRCP.	CDC25A BTRC	4.14e-05	4	92	2	15536641
Pubmed	CCR7 Is Important for Mesangial Cell Physiology and Repair.	PDGFRB MKI67	4.14e-05	4	92	2	29077526
Pubmed	Hierarchical order of phosphorylation events commits Cdc25A to betaTrCP-dependent degradation.	CDC25A BTRC	4.14e-05	4	92	2	14752276
Pubmed	Gp78, an E3 ubiquitin ligase acts as a gatekeeper suppressing nonalcoholic steatohepatitis (NASH) and liver cancer.	AMFR MKI67	4.14e-05	4	92	2	25789613
Pubmed	The adaptor molecule Lnk negatively regulates tumor necrosis factor-alpha-dependent VCAM-1 expression in endothelial cells through inhibition of the ERK1 and -2 pathways.	SH2B3 VCAM1	4.14e-05	4	92	2	16644735
Pubmed	Regulated degradation of the HIV-1 Vpu protein through a betaTrCP-independent pathway limits the release of viral particles.	CDC25A BTRC	4.14e-05	4	92	2	17676996
Pubmed	Structural and functional dissection of the cytoplasmic domain of the transmembrane adaptor protein SIT (SHP2-interacting transmembrane adaptor protein).	CSK SIT1	4.14e-05	4	92	2	11433379
Pubmed	A transmembrane osteoclastic protein-tyrosine phosphatase regulates osteoclast activity in part by promoting osteoclast survival through c-Src-dependent activation of NFkappaB and JNK2.	CSK PTPRO	4.14e-05	4	92	2	17400176
Pubmed	Expression profiling in transgenic FVB/N embryonic stem cells overexpressing STAT3.	PRAMEF10 PRAMEF17 PRAMEF18	4.46e-05	26	92	3	18500982
Pubmed	FoxOs enforce a progression checkpoint to constrain mTORC1-activated renal tumorigenesis.	FOXO4 TSC1	6.89e-05	5	92	2	21075312
Pubmed	Transforming growth factor beta facilitates beta-TrCP-mediated degradation of Cdc25A in a Smad3-dependent manner.	CDC25A BTRC	6.89e-05	5	92	2	15798217
Pubmed	SCFbeta-TRCP links Chk1 signaling to degradation of the Cdc25A protein phosphatase.	CDC25A BTRC	6.89e-05	5	92	2	14681206
Pubmed	The p97-Ufd1-Npl4 ATPase complex ensures robustness of the G2/M checkpoint by facilitating CDC25A degradation.	CDC25A BTRC	6.89e-05	5	92	2	24429874
Pubmed	mTORC1 activation in B cells confers impairment of marginal zone microarchitecture by exaggerating cathepsin activity.	CD19 TSC1	6.89e-05	5	92	2	30144045
Pubmed	LSM14B is essential for oocyte meiotic maturation by regulating maternal mRNA storage and clearance.	PRAMEF10 PRAMEF17 PRAMEF18	8.40e-05	32	92	3	37889087
Pubmed	mTORC1 promotes denervation-induced muscle atrophy through a mechanism involving the activation of FoxO and E3 ubiquitin ligases.	FOXO4 TSC1	1.03e-04	6	92	2	24570486
Pubmed	Expression of the Arf tumor suppressor gene is controlled by Tgfbeta2 during development.	PDGFRB MKI67	1.03e-04	6	92	2	19465598
Pubmed	Phosphorylation and binding partner analysis of the TSC1-TSC2 complex.	DOCK7 TSC1	1.03e-04	6	92	2	15963462
Pubmed	Associations between HLA-DRB1, RANK, RANKL, OPG, and IL-17 genotypes and disease severity phenotypes in Japanese patients with early rheumatoid arthritis.	IL17RA TNFRSF11A	1.03e-04	6	92	2	17876645
Pubmed	Patterning of palatal rugae through sequential addition reveals an anterior/posterior boundary in palatal development.	TBX22 MKI67	1.03e-04	6	92	2	19087265
Pubmed	Akhirin regulates the proliferation and differentiation of neural stem cells/progenitor cells at neurogenic niches in mouse brain.	MKI67 VCAM1	1.03e-04	6	92	2	31943155
Pubmed	Two additional protein-tyrosine kinases expressed in human lung: fourth member of the fibroblast growth factor receptor family and an intracellular protein-tyrosine kinase.	CSK PDGFRB	1.03e-04	6	92	2	1720539
Pubmed	mTOR activation promotes plasma cell differentiation and bypasses XBP-1 for immunoglobulin secretion.	CD19 TSC1	1.03e-04	6	92	2	25332234
Pubmed	The L-type amino acid transporter LAT1 inhibits osteoclastogenesis and maintains bone homeostasis through the mTORC1 pathway.	TSC1 TNFRSF11A	1.03e-04	6	92	2	31289211
Pubmed	Extracellular matrix of secondary lymphoid organs impacts on B-cell fate and survival.	CD19 VCAM1	1.03e-04	6	92	2	23847204
Pubmed	The ubiquitin-specific protease USP47 is a novel beta-TRCP interactor regulating cell survival.	CDC25A BTRC	1.03e-04	6	92	2	19966869
Pubmed	Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes.	SH2B3 DNAH2 CLEC16A	1.30e-04	37	92	3	19430480
Pubmed	A Novel Role for GATA3 in Mesangial Cells in Glomerular Development and Injury.	PDGFRB MKI67	1.44e-04	7	92	2	31405951
Pubmed	Identification of substrates for F-box proteins.	CDC25A BTRC	1.44e-04	7	92	2	16338364
Pubmed	Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins.	AMFR PLA2R1 GPR101 CR1L	1.54e-04	101	92	4	23382219
Pubmed	A directed protein interaction network for investigating intracellular signal transduction.	CCDC88C AMFR SORBS2 DCAF13 PTPRO SEM1 MKI67 DOCK7 APLP1 CDC25A BTRC	1.88e-04	1124	92	11	21900206
Pubmed	Expression pattern changes and function of RANKL during mouse lymph node microarchitecture development.	TNFRSF11A VCAM1	1.92e-04	8	92	2	22354913
Pubmed	Cell Adhesion Mediated by VCAM-ITGα9 Interactions Enables Lymphatic Development.	MKI67 VCAM1	1.92e-04	8	92	2	25745057
Pubmed	NSMCE2 suppresses cancer and aging in mice independently of its SUMO ligase activity.	CD19 MKI67	1.92e-04	8	92	2	26443207
Pubmed	LKB1 in endothelial cells is required for angiogenesis and TGFbeta-mediated vascular smooth muscle cell recruitment.	PDGFRB MKI67	1.92e-04	8	92	2	18539926
Pubmed	Expression of eight genes of nuclear factor-kappa B pathway in multiple myeloma using bone marrow aspirates obtained at diagnosis.	TNFRSF11A VCAM1	1.92e-04	8	92	2	19554506
Pubmed	Pcif1 modulates Pdx1 protein stability and pancreatic β cell function and survival in mice.	MKI67 SPOP	1.92e-04	8	92	2	20811152
Pubmed	Postnatal liver functional maturation requires Cnot complex-mediated decay of mRNAs encoding cell cycle and immature liver genes.	MKI67 CDC25A CES2	2.05e-04	43	92	3	30733279
Pubmed	CENP-W inhibits CDC25A degradation by destabilizing the SCFβ-TrCP-1 complex at G2/M.	CDC25A BTRC	2.46e-04	9	92	2	29863914
Pubmed	Mechanosensitive mTORC1 signaling maintains lymphatic valves.	MKI67 TSC1	2.46e-04	9	92	2	37036444
Pubmed	Coordination of Cellular Dynamics Contributes to Tooth Epithelium Deformations.	MKI67 SSH2	2.46e-04	9	92	2	27588418
Pubmed	Cdh1 regulates cell cycle through modulating the claspin/Chk1 and the Rb/E2F1 pathways.	CDC25A BTRC	2.46e-04	9	92	2	19477924
Pubmed	Large-scale structural analysis of the classical human protein tyrosine phosphatome.	CSK PDGFRB PTPRO	2.67e-04	47	92	3	19167335
Pubmed	Cyclin D-CDK4 kinase destabilizes PD-L1 via cullin 3-SPOP to control cancer immune surveillance.	SPOP BTRC	3.07e-04	10	92	2	29160310
Pubmed	Spatial and temporal regulation of coronary vessel formation by calcineurin-NFAT signaling.	PDGFRB MKI67	3.07e-04	10	92	2	19710169
Pubmed	Confirmation of the genetic association of CTLA4 and PTPN22 with ANCA-associated vasculitis.	SH2B3 CLEC16A	3.07e-04	10	92	2	19951419
Pubmed	Genetic evidence for a role of IL33 in nasal polyposis.	WDR36 SH2B3	3.07e-04	10	92	2	19860791
Pubmed	Mechanism of cystogenesis by Cd79a-driven, conditional mTOR activation in developing mouse nephrons.	MKI67 TSC1	3.07e-04	10	92	2	36627370
Pubmed	Linking cortical astrocytic neogenin deficiency to the development of Moyamoya disease-like vasculopathy.	PDGFRB MKI67	3.07e-04	10	92	2	33775822
Pubmed	Degradation of Cdc25A by beta-TrCP during S phase and in response to DNA damage.	CDC25A BTRC	3.07e-04	10	92	2	14603323
Pubmed	Defining the human deubiquitinating enzyme interaction landscape.	ASXL1 WDR36 ARHGEF10 DOCK7 AASDHPPT LRRC14 SRPX CDC25A USP27X BTRC	3.29e-04	1005	92	10	19615732
Pubmed	Wt1 dictates the fate of fetal and adult Leydig cells during development in the mouse testis.	MKI67 VCAM1	3.75e-04	11	92	2	25336526
Pubmed	Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction.	WDR36 SH2B3	3.75e-04	11	92	2	19198610
Pubmed	A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus.	SH2B3 CLEC16A	3.75e-04	11	92	2	19838195
Pubmed	An essential function for the nuclear receptor RORgamma(t) in the generation of fetal lymphoid tissue inducer cells.	MKI67 VCAM1	3.75e-04	11	92	2	14691482
Pubmed	Integrin β3 inhibition is a therapeutic strategy for supravalvular aortic stenosis.	PDGFRB MKI67	3.75e-04	11	92	2	26858344
Pubmed	Polymorphisms in CLEC16A and CIITA at 16p13 are associated with primary adrenal insufficiency.	SH2B3 CLEC16A	3.75e-04	11	92	2	18593762
Pubmed	Pias1 is essential for erythroid and vascular development in the mouse embryo.	MKI67 VCAM1	3.75e-04	11	92	2	27155222
Pubmed	USP7 represses lineage differentiation genes in mouse embryonic stem cells by both catalytic and noncatalytic activities.	NUTM1 PLA2R1 PRAMEF10 PRAMEF17 UBE2QL1 PRAMEF18 LAS1L TTLL13	4.25e-04	674	92	8	37196079
Pubmed	USP22 controls multiple signaling pathways that are essential for vasculature formation in the mouse placenta.	PDGFRB MKI67 VCAM1	4.49e-04	56	92	3	30718289
Pubmed	Hepatocyte growth factor-regulated tyrosine kinase substrate is essential for endothelial cell polarity and cerebrovascular stability.	PDGFRB MKI67	4.49e-04	12	92	2	32044971
Pubmed	Ptch1 is essential for cochlear marginal cell differentiation and stria vascularis formation.	MKI67 SPOP	4.49e-04	12	92	2	38602877
Pubmed	XIAP and PHB1 Regulate Anoikis through Competitive Binding to TRAF6.	CSK PTK7	4.49e-04	12	92	2	36346305
Pubmed	Forkhead factor FoxO1 is essential for placental morphogenesis in the developing embryo.	MKI67 VCAM1	4.49e-04	12	92	2	21930913
Pubmed	Neogenin-loss in neural crest cells results in persistent hyperplastic primary vitreous formation.	PDGFRB MKI67	4.49e-04	12	92	2	31336386
Interaction	YWHAZ interactions	CCDC88C TICRR ASXL1 SORBS2 SH2B3 CSK PTPRO CEP95 DOCK7 FAM53B FOXO4 TSC1 SPOP SSH2 CDC25A BTRC CFAP410 VCAM1 GABBR1 OTOG	7.62e-07	1319	88	20	int:YWHAZ
Cytoband	1p36.21	PRAMEF33 PRAMEF10 PRAMEF17 PRAMEF18	8.22e-06	63	92	4	1p36.21
GeneFamily	Hyalectan proteoglycans\|V-set domain containing\|Sushi domain containing\|C-type lectin domain containing	SRPX CR1L CSMD3 SVEP1 GABBR1	1.35e-06	57	61	5	1179
GeneFamily	PRAME family	PRAMEF10 PRAMEF17 PRAMEF18	7.03e-05	24	61	3	686
GeneFamily	Immunoglobulin like domain containing	CD19 PDGFRB CEACAM16 VCAM1 PTK7	4.82e-04	193	61	5	594
GeneFamily	WD repeat domain containing	WDR91 DCAF13 WDR36 WDR25 BTRC	1.89e-03	262	61	5	362
GeneFamily	ADAM metallopeptidase domain containing\|CD molecules	MELTF CD19 PDGFRB IL17RA TNFRSF11A VCAM1	2.08e-03	394	61	6	471
GeneFamily	Complement system\|Sushi domain containing	C9 CR1L	6.55e-03	36	61	2	492
GeneFamily	Receptor Tyrosine Kinases\|CD molecules	PDGFRB PTK7	8.04e-03	40	61	2	321
GeneFamily	Basic leucine zipper proteins\|BTB domain containing	IBTK SPOP KLHL17	1.05e-02	134	61	3	861
GeneFamily	C-type lectin domain family	PLA2R1 CLEC16A	1.10e-02	47	61	2	494
Coexpression	GSE3982_MAST_CELL_VS_NKCELL_DN	NELL1 ASXL1 CSK DNAH2 SCTR APLP1 FAM53B SIT1	5.17e-07	199	92	8	M5452
Coexpression	INGRAM_SHH_TARGETS_UP	PRAMEF33 PRAMEF10 ARHGEF10 PRAMEF17 PRAMEF18 PTK7	1.89e-05	156	92	6	MM550
ToppCell	LPS_IL1RA_TNF-Mesenchymal_fibroblastic-Fibroblasts-MatrixFB\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	NELL1 PDGFRB SRPX SVEP1 VCAM1 PTK7	3.61e-06	199	92	6	30d3e8c0681ec11f86dd38c5f48d21187a1b4f90
ToppCell	368C-Fibroblasts-Fibroblast-E\|368C / Donor, Lineage, Cell class and subclass (all cells)	TICRR PDGFRB SRPX ZSWIM1 SVEP1	2.17e-05	162	92	5	e17632778a57c71d6005d3abca3a0443a92040e7
ToppCell	368C-Fibroblasts-Fibroblast-E-\|368C / Donor, Lineage, Cell class and subclass (all cells)	TICRR PDGFRB SRPX ZSWIM1 SVEP1	2.17e-05	162	92	5	ac4a80fd72c9311ea2b3e574c6284bbce4f2756c
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-Adaptive_/_Maladaptive_/_Repairing_Fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PLA2R1 PDGFRB SRPX HHIPL1 SVEP1	3.14e-05	175	92	5	795a6564d5a75ffd35d39f5274b9e8d28708bbc8
ToppCell	PBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Lymphocytic-Lymphocytic_ILC-NK_cell-NK_c03-MKI67\|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)	TICRR MELTF PDGFRB MKI67 CDC25A	3.41e-05	178	92	5	dbde3305e0c6a81593fe614e3f2e746b32cc16a7
ToppCell	facs-Kidney-nan-3m-Mesenchymal-mesangial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PDGFRB APLP1 SRPX HHIPL1 SVEP1	4.54e-05	189	92	5	a5306561026e4dfcc39beeb785e5108ac595d136
ToppCell	facs-Kidney-nan-3m-Mesenchymal\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PDGFRB APLP1 SRPX HHIPL1 SVEP1	4.54e-05	189	92	5	381058f55908f84375b54601d617389ef43ab855
ToppCell	facs-Kidney-nan-3m-Mesenchymal-mesangial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PDGFRB APLP1 SRPX HHIPL1 SVEP1	4.54e-05	189	92	5	302b950a6ad578f8aeff7ea6fd15fe631225287d
ToppCell	Tracheal-10x3prime_v2-Immune_Lymphocytic-B-B_cell-B_naive\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	SCTR LRRC14 ZSWIM1 SIT1	5.74e-05	101	92	4	86acaa2502f61baa714ae988b73e3e73a71e897e
ToppCell	LPS_IL1RA-Mesenchymal_fibroblastic-Fibroblasts\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	PDGFRB SRPX SVEP1 VCAM1 PTK7	5.79e-05	199	92	5	ba586690f88fd051f449753bfe7603a2cb431782
ToppCell	LPS_IL1RA-Mesenchymal_fibroblastic-Fibroblasts-Diff_MatrixFB\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	PDGFRB SRPX SVEP1 VCAM1 PTK7	5.79e-05	199	92	5	38ed3bc7daa993d9edcf3e7834597ebb06dd24f8
ToppCell	LPS_IL1RA-Mesenchymal_fibroblastic\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	PDGFRB SRPX SVEP1 VCAM1 PTK7	5.79e-05	199	92	5	06a7d874ff7c4616577f6e59d3118717a8c47c00
ToppCell	LPS_only-Mesenchymal_fibroblastic-Fibroblasts-Activated_MatrixFB\|LPS_only / Treatment groups by lineage, cell group, cell type	PDGFRB SRPX SVEP1 VCAM1 PTK7	5.79e-05	199	92	5	fde2b65afde69f402f1b7b056eaa266e9fd5b227
ToppCell	LPS_IL1RA_TNF-Mesenchymal_fibroblastic-Fibroblasts-Activated_MatrixFB\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	PDGFRB SRPX SVEP1 VCAM1 PTK7	5.79e-05	199	92	5	e1849505b92820a219c5a2c35492bdd55579fb48
ToppCell	LPS_IL1RA-Mesenchymal_fibroblastic-Fibroblasts-Activated_MatrixFB\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	WDR36 PDGFRB SVEP1 VCAM1 PTK7	5.79e-05	199	92	5	8b86c69aaf60feff53aa782559cfece7342a23de
ToppCell	LPS_anti-TNF-Mesenchymal_fibroblastic-Fibroblasts-MatrixFB\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	NELL1 PDGFRB SVEP1 VCAM1 PTK7	5.93e-05	200	92	5	9b0916d8d07ac2bf1739f7be5296bf77ffee6094
ToppCell	Control_saline-Mesenchymal_fibroblastic\|Control_saline / Treatment groups by lineage, cell group, cell type	NELL1 PDGFRB SRPX SVEP1 PTK7	5.93e-05	200	92	5	64ae5cf6cb4fc94cf1052abd82648f6b8e6445fe
ToppCell	LPS_anti-TNF-Mesenchymal_fibroblastic-Fibroblasts\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	PDGFRB SRPX SVEP1 VCAM1 PTK7	5.93e-05	200	92	5	b79628fd1386aa9a3b0e9fa81def0bc100c3c073
ToppCell	Macroglial-Polydendrocytes-PDGFRA-\|Macroglial / cells hierarchy compared to all cells using T-Statistic	NELL1 SORBS2 PTPRO CSMD3 UNC80	5.93e-05	200	92	5	f17b5a54e8f9eba9dcd0808ba4e8d275ac41bce2
ToppCell	Macroglial-Polydendrocytes-PDGFRA--\|Macroglial / cells hierarchy compared to all cells using T-Statistic	NELL1 SORBS2 PTPRO CSMD3 UNC80	5.93e-05	200	92	5	cc3409518f8b436ea92deb955e81114b3f410ff7
ToppCell	LPS_anti-TNF-Mesenchymal_fibroblastic\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	PDGFRB SRPX SVEP1 VCAM1 PTK7	5.93e-05	200	92	5	50ca6550998e461ef26dd670351060bd940765a8
ToppCell	Macroglial-Polydendrocytes-PDGFRA\|Macroglial / cells hierarchy compared to all cells using T-Statistic	NELL1 SORBS2 PTPRO CSMD3 UNC80	5.93e-05	200	92	5	c24a3099e3d96d8b72f6d05286bb355d661a0377
ToppCell	LPS_anti-TNF-Mesenchymal_fibroblastic-Fibroblasts-Diff_MatrixFB\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	PDGFRB SRPX SVEP1 VCAM1 PTK7	5.93e-05	200	92	5	3bdba9612cd7c612b76aa9abecc4a6529aabfc1c
ToppCell	LPS_IL1RA_TNF-Mesenchymal_fibroblastic-Fibroblasts\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	PDGFRB SRPX SVEP1 VCAM1 PTK7	5.93e-05	200	92	5	44a68bacdb3d5bf563bd35952176995850933a81
ToppCell	Macroglial-Polydendrocytes-PDGFRA---\|Macroglial / cells hierarchy compared to all cells using T-Statistic	NELL1 SORBS2 PTPRO CSMD3 UNC80	5.93e-05	200	92	5	4fc3de4bff7ed2bf40b38462c4b4e9b87af6a4ca
ToppCell	Control_saline-Mesenchymal_fibroblastic-Fibroblasts\|Control_saline / Treatment groups by lineage, cell group, cell type	NELL1 PDGFRB SRPX SVEP1 PTK7	5.93e-05	200	92	5	a1fc74c1b27e104895910bc7cdce7ba33d30df7e
ToppCell	LPS_IL1RA_TNF-Mesenchymal_fibroblastic\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	PDGFRB SRPX SVEP1 VCAM1 PTK7	5.93e-05	200	92	5	dc61016c61729f69649cfb21f6264e685ce83dea
ToppCell	Macroglial-Polydendrocytes-PDGFRA----L1-6\|Macroglial / cells hierarchy compared to all cells using T-Statistic	NELL1 SORBS2 PTPRO CSMD3 UNC80	5.93e-05	200	92	5	310cd53db1c137f6af74e6ae682221d7ac27310c
ToppCell	Control_saline-Mesenchymal_fibroblastic-Fibroblasts-MatrixFB\|Control_saline / Treatment groups by lineage, cell group, cell type	NELL1 PDGFRB SRPX SVEP1 PTK7	5.93e-05	200	92	5	bd8cf33502adea320e91ca2af14e1911d88ad374
ToppCell	Macroglial-Polydendrocytes\|Macroglial / cells hierarchy compared to all cells using T-Statistic	NELL1 SORBS2 PTPRO CSMD3 UNC80	5.93e-05	200	92	5	961858738ce35db8760c8c2e136f8369bc444ccf
ToppCell	(09)_Ionocytes-(3)_72hpi\|(09)_Ionocytes / shred by cell type and Timepoint	SORBS2 GPC2 CDC25A PTK7	8.01e-05	110	92	4	fce7d5a0617fc664b657f5bb9abb290e7cc234cb
Disease	myeloproliferative neoplasm (implicated_via_orthology)	ASXL1 PDGFRB	4.67e-05	4	83	2	DOID:2226 (implicated_via_orthology)
Disease	interstitial cystitis (is_marker_for)	MKI67 VCAM1	7.77e-05	5	83	2	DOID:13949 (is_marker_for)
Disease	brain connectivity measurement	CCDC88C NELL1 PLAC1 SH2B3 SEM1 FAM53B SSH2	1.37e-04	400	83	7	EFO_0005210
Disease	Ectrodactyly	SEM1 BTRC	1.63e-04	7	83	2	C0265554
Disease	neuropilin-1 measurement	NELL1 DOCK7	1.63e-04	7	83	2	EFO_0020603
Disease	vascular cell adhesion protein 1 measurement	SH2B3 VCAM1	1.63e-04	7	83	2	EFO_0020846
Disease	myelofibrosis (is_implicated_in)	ASXL1 SH2B3	2.16e-04	8	83	2	DOID:4971 (is_implicated_in)
Disease	Libman-Sacks Disease	SH2B3 CSK CLEC16A	5.92e-04	58	83	3	C0242380
Disease	tumor necrosis factor measurement	SH2B3 HPX	8.02e-04	15	83	2	EFO_0010834
Disease	autosomal recessive polycystic kidney disease (implicated_via_orthology)	TSC1 CDC25A	9.14e-04	16	83	2	DOID:0110861 (implicated_via_orthology)
Disease	asthma, age at onset	WDR36 TNFRSF11A CLEC16A	1.03e-03	70	83	3	EFO_0004847, MONDO_0004979
Disease	rhinitis	WDR36 CLEC16A	1.03e-03	17	83	2	EFO_0008521
Disease	Lupus Erythematosus, Systemic	SH2B3 CSK CLEC16A	1.07e-03	71	83	3	C0024141
Disease	allergic disease, age at onset	WDR36 TNFRSF11A CLEC16A	1.07e-03	71	83	3	EFO_0004847, MONDO_0005271
Disease	Juvenile Myelomonocytic Leukemia	ASXL1 SH2B3	1.30e-03	19	83	2	C0349639
Disease	Diuretic use measurement	TICRR SH2B3 CSK CDC25A	1.34e-03	169	83	4	EFO_0009928
Disease	cardiovascular disease	SH2B3 CSK DOCK7 CDC25A HIBADH SVEP1	1.85e-03	457	83	6	EFO_0000319
Disease	Agents acting on the renin-angiotensin system use measurement	TICRR SH2B3 CSK CDC25A SVEP1	2.58e-03	335	83	5	EFO_0009931

Protein segments in the cluster

Peptide	Gene	Start	Entry
WSGARVLSCSPEAMS	PRAMEF33	116	A0A0G2JMD5
VPSMEGVRWAFSCGT	AASDHPPT	11	Q9NRN7
PSLNRAERGIWSCSM	ARHGEF10	11	O15013
AERGIWSCSMDQREP	ARHGEF10	16	O15013
WGSRLTDISICQEMP	CFAP410	26	O43822
TINGTWSGVMPTCRA	CSMD3	3216	Q7Z407
WSGVMPTCRAVTCPT	CSMD3	3221	Q7Z407
LMCSSPSPTAEVRWF	CEACAM16	151	Q2WEN9
RSLWLGCSSLADSMP	BTRC	21	Q9Y297
TQAIPMERWCGGSRS	APLP1	111	P51693
MSAIQAAWPSGTECI	CSK	1	P41240
TNPICSMTWGFDSIS	DCAF13	186	Q9NV06
TDGMVAPQSWVSRVC	ASXL1	1056	Q8IXJ9
AAACRGMSWTPAETN	MSANTD2	96	Q6P1R3
SSPLAESEWDFIMCS	LTN1	1236	O94822
CMSSGSLWDPNITVE	IL17RA	196	Q96F46
STVQTSLAMRWPFCG	OR13C4	156	Q8NGS5
WSGARALSCSPEAMS	PRAMEF17	116	Q5VTA0
MWRCSFDRGDPSSGT	HHIPL1	396	Q96JK4
SRMAADASLEAAPCW	GPC2	416	Q8N158
SWIEASSCAALEMPI	IBTK	801	Q9P2D0
CLANGSWTDMDTPSR	GABBR1	81	Q9UBS5
SWTDMDTPSRCVRIC	GABBR1	86	Q9UBS5
LAMRSWPSELGSRTC	CCDC88C	1506	Q9P219
DEMSSCRTSWRPLGS	FAM53B	121	Q14153
SPCSRNREEADMWTT	FOXO4	241	P98177
SWSGVRDGTTHPAMC	CES2	81	O00748
WSGARLLSCSPEAMS	PRAMEF18	116	Q5VWM3
RRDCMWSGFSTQEPL	MYCLP1	86	P12525
CSASLDWPRMVESCL	LAS1L	456	Q9Y4W2
SRTWGQKCAPMSDLT	MKI67	951	P46013
DERNALCSMIWGASP	GPR101	176	Q96P66
LSGSVWTMAGSPCTT	NELL1	776	Q92832
MADSERLSAPGCWAA	PLP2	1	Q04941
VCLSPGVWLSSEMDA	NUTM1	716	Q86Y26
FRVTMVTWGDPELSC	PTPRO	606	Q16827
PDLISTAMAADCWRS	MAP3K13	696	O43283
TAMAADCWRSSEPDK	MAP3K13	701	O43283
GACWLPRISSMSSLT	NPY6R	271	Q99463
WQPEVSMGTRRSCLG	KLHL17	416	Q6TDP4
MSIDDTPRGSWACSI	DOCK7	181	Q96N67
MSATTACWPAFTVLG	CSAG1	1	Q6PB30
QDLTMAPGSTLWLSC	CD19	186	P15391
GMESLWNSSVPVCER	CR1L	396	Q2VPA4
FGRCSLSSEMLGPSW	CEP95	156	Q96GE4
ACLPERDWAESTLMT	F10	341	P00742
WTDGILSSVMRTACA	DNAH2	2141	Q9P225
GSASHIDCRMSPWSE	C9	36	P02748
EETPSCMASLWTAPL	CDC25A	231	P30304
VLTCSGSAPVVWERM	PDGFRB	51	P09619
CTDSMGVPRALGETW	OTOG	2436	Q6ZRI0
TMKERSWPAVGNCSS	HPX	176	P02790
SGQSPMTVLCSIDWF	PLAC1	21	Q9HBJ0
SVMGCESPSFSWRTQ	VCAM1	336	P19320
TVLGGMEVRWCATSD	MELTF	16	P08582
LECSWVLRVSPSSMA	OVCH1	871	Q7RTY7
EMPNSRATTELAWVC	SEM1	61	Q6ZVN7
SNLAWSGTEPTCAAM	SRPX	306	P78539
CEESGWSSSIPTCMP	SVEP1	2596	Q4LDE5
FMPSAWRSRDCESTL	PLA2R1	336	Q13018
TGLWGSEECSVSMPS	PLA2R1	921	Q13018
RAWSQCSTEEVPRDM	SORBS2	491	O94875
IASMLGSTDIPDWCV	APEH	616	P13798
MSSGRCWSSDTYNPV	HIBADH	246	P31937
RSWLEQDTSCPTCRM	AMFR	366	Q9UKV5
CSESTQWSRPFLDMV	CLEC16A	471	Q2KHT3
SCTSFWPMSPGRESS	USP27X	236	A6NNY8
SRWETTMGEASASIP	TSC1	1061	Q92574
SPAMCSSFTRDLWPE	ZNF714	46	Q96N38
SWMLGSPEESTATQR	TICRR	361	Q7Z2Z1
AICMELLTPRGWSSA	UBE2QL1	86	A1L167
RTPCEWGMDAISATL	UNC80	1941	Q8N2C7
NDSSTCTMGLVLPLW	SSH2	131	Q76I76
TSSEVCNADWMASLP	PLCXD2	26	Q0VAA5
DSPCSGETWMRQIIS	TBX22	181	Q9Y458
SSELCETVSSWMGPL	PLEKHG4B	521	Q96PX9
AEMSSGPVAESWCYT	SPOP	11	O43791
MGWLLPECSVTDSVN	TINF2	196	Q9BSI4
SQPGWSRTDCVMIST	TLCD3A	26	Q8TBR7
MASRLPTAWSCEPVT	ZNF274	1	Q96GC6
DNISCWPSSVPGRMV	SCTR	71	P47872
FCSMSCRAWVSPEEL	SPDYE1	301	Q8NFV5
ISDCPVWMDSSTTAQ	XYLB	131	O75191
WSGARVLSCSPEAMS	PRAMEF10	116	O60809
NSWMAELSECTGRGL	SH2B3	296	Q9UQQ2
VLPSVLATCSWGGDM	WDR25	526	Q64LD2
DMLPAQWTAGCATSL	ZSWIM1	411	Q9BR11
GRPTCWSTATMGDQF	VSIG10L2	416	P0DP72
RAPVVTVDWSTAMDC	WDR91	711	A4D1P6
GTWYRCMSSTPAGSI	PTK7	476	Q13308
VCLWTLTSAAMSRGD	SIT1	11	Q9Y3P8
MVGEFTRDGSWCSIL	ZNF175	121	Q9Y473
EPLCRTDWTPMSSEN	TNFRSF11A	406	Q9Y6Q6
SDSWTECTLPSMVNS	TTLL13	771	A6NNM8
SPDGRWLISAAMDCS	WDR36	631	Q8NI36
AMDCSIRTWDLPSGC	WDR36	641	Q8NI36
GTPQASCSDWMTVLR	ZNF554	141	Q86TJ5
PGTMSMWDCTAAVAR	LRRC14	131	Q15048