Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionolfactory receptor activity

OR5AC1 OR2T6 OR11H1 OR10G2 OR2T35 OR10AD1 OR2T1 OR2D2 OR5K3 OR2Z1 OR11H12 OR5K1 OR11H2

1.09e-094316513GO:0004984
GeneOntologyMolecularFunctionG protein-coupled receptor activity

OR5AC1 OR2T6 TRHR OR11H1 OR10G2 OR2T35 OR10AD1 OR2T1 OR2D2 OR5K3 OR2Z1 OR11H12 OR5K1 OR11H2

7.44e-078846514GO:0004930
GeneOntologyMolecularFunctiontransmembrane signaling receptor activity

OR5AC1 OR2T6 TRHR OR11H1 OR10G2 OR2T35 OR10AD1 OR2T1 OR2D2 OR5K3 GRIK1 OR2Z1 OR11H12 OR5K1 OR11H2

2.23e-0513536515GO:0004888
GeneOntologyMolecularFunctionGTPase activator activity

RGPD4 ARHGAP32 RGPD8 RASA1 RGPD3 PREX1 RGPD5

3.36e-05279657GO:0005096
GeneOntologyMolecularFunctionSUMO ligase activity

RGPD4 RGPD8 RGPD3

3.61e-0520653GO:0061665
GeneOntologyMolecularFunctionSUMO transferase activity

RGPD4 RGPD8 RGPD3

2.18e-0436653GO:0019789
GeneOntologyMolecularFunctionnucleoside-triphosphatase regulator activity

RGPD4 ARHGAP32 RGPD8 RASA1 RGPD3 ARHGEF3 PREX1 RGPD5

2.32e-04507658GO:0060589
GeneOntologyMolecularFunctionGTPase regulator activity

RGPD4 ARHGAP32 RGPD8 RASA1 RGPD3 ARHGEF3 PREX1 RGPD5

2.32e-04507658GO:0030695
GeneOntologyMolecularFunctionvery long-chain fatty acid-CoA ligase activity

SLC27A5 SLC27A4

4.62e-0410652GO:0031957
GeneOntologyMolecularFunctionpeptidyl-prolyl cis-trans isomerase activity

RGPD4 RGPD8 RGPD3

5.78e-0450653GO:0003755
GeneOntologyMolecularFunctioncis-trans isomerase activity

RGPD4 RGPD8 RGPD3

6.87e-0453653GO:0016859
GeneOntologyMolecularFunctionlong-chain fatty acid-CoA ligase activity

SLC27A5 SLC27A4

1.07e-0315652GO:0004467
GeneOntologyMolecularFunctionlong-chain fatty acid transmembrane transporter activity

SLC27A5 SLC27A4

1.54e-0318652GO:0005324
GeneOntologyMolecularFunctionfatty acid transmembrane transporter activity

SLC27A5 SLC27A4

2.53e-0323652GO:0015245
GeneOntologyMolecularFunctionphosphatidylinositol kinase activity

PIK3R6 PIPSL

3.22e-0326652GO:0052742
GeneOntologyMolecularFunctionfatty acid ligase activity

SLC27A5 SLC27A4

3.22e-0326652GO:0015645
GeneOntologyMolecularFunctionCoA-ligase activity

SLC27A5 SLC27A4

3.47e-0327652GO:0016405
GeneOntologyMolecularFunctionacid-thiol ligase activity

SLC27A5 SLC27A4

4.57e-0331652GO:0016878
GeneOntologyBiologicalProcessdetection of chemical stimulus involved in sensory perception of smell

OR5AC1 OR2T6 OR11H1 OR10G2 OR2T35 OR10AD1 OR2T1 OR2D2 OR5K3 OR2Z1 OR11H12 OR5K1 OR11H2

6.21e-104326413GO:0050911
GeneOntologyBiologicalProcesssensory perception of smell

OR5AC1 OR2T6 OR11H1 OR10G2 OR2T35 OR10AD1 OR2T1 OR2D2 OR5K3 OR2Z1 OR11H12 OR5K1 OR11H2

1.52e-094656413GO:0007608
GeneOntologyBiologicalProcessdetection of chemical stimulus involved in sensory perception

OR5AC1 OR2T6 OR11H1 OR10G2 OR2T35 OR10AD1 OR2T1 OR2D2 OR5K3 OR2Z1 OR11H12 OR5K1 OR11H2

2.52e-094856413GO:0050907
GeneOntologyBiologicalProcessdetection of chemical stimulus

OR5AC1 OR2T6 OR11H1 OR10G2 OR2T35 OR10AD1 OR2T1 OR2D2 OR5K3 OR2Z1 OR11H12 OR5K1 OR11H2

6.37e-095246413GO:0009593
GeneOntologyBiologicalProcesssensory perception of chemical stimulus

OR5AC1 OR2T6 OR11H1 OR10G2 OR2T35 OR10AD1 OR2T1 OR2D2 OR5K3 OR2Z1 OR11H12 OR5K1 OR11H2

1.06e-085476413GO:0007606
GeneOntologyBiologicalProcessdetection of stimulus involved in sensory perception

OR5AC1 OR2T6 OR11H1 OR10G2 OR2T35 OR10AD1 OR2T1 OR2D2 OR5K3 OR2Z1 OR11H12 OR5K1 OR11H2

2.21e-085826413GO:0050906
GeneOntologyBiologicalProcessdetection of stimulus

OR5AC1 OR2T6 OR11H1 OR10G2 OR2T35 OR10AD1 OR2T1 OR2D2 OR5K3 OR2Z1 OR11H12 OR5K1 OR11H2

2.69e-077226413GO:0051606
GeneOntologyBiologicalProcessNLS-bearing protein import into nucleus

RGPD4 RGPD8 RGPD3 RGPD5

3.93e-0720644GO:0006607
GeneOntologyBiologicalProcessG protein-coupled receptor signaling pathway

GPRASP1 OR5AC1 OR2T6 PIK3R6 TRHR OR11H1 OR10G2 OR2T35 OR10AD1 OR2T1 OR2D2 OR5K3 OR2Z1 OR11H12 OR5K1 OR11H2 PREX1

7.71e-0713956417GO:0007186
GeneOntologyBiologicalProcesspositive regulation of glucokinase activity

RGPD4 RGPD8 RGPD3

2.36e-069643GO:0033133
GeneOntologyBiologicalProcesspositive regulation of hexokinase activity

RGPD4 RGPD8 RGPD3

3.37e-0610643GO:1903301
GeneOntologyBiologicalProcessregulation of glucokinase activity

RGPD4 RGPD8 RGPD3

7.97e-0613643GO:0033131
GeneOntologyBiologicalProcessregulation of hexokinase activity

RGPD4 RGPD8 RGPD3

1.01e-0514643GO:1903299
GeneOntologyBiologicalProcesssensory perception

OR5AC1 OR2T6 OR11H1 OR10G2 OR2T35 OR10AD1 OR2T1 OR2D2 OR5K3 OR2Z1 OR11H12 OR5K1 OR11H2

2.08e-0510726413GO:0007600
GeneOntologyBiologicalProcessglucose import in response to insulin stimulus

SLC2A4 SLC27A4

1.41e-046642GO:0044381
GeneOntologyBiologicalProcessprotein peptidyl-prolyl isomerization

RGPD4 RGPD8 RGPD3

2.22e-0438643GO:0000413
GeneOntologyBiologicalProcesspeptidyl-proline modification

RGPD4 RGPD8 RGPD3

6.31e-0454643GO:0018208
GeneOntologyCellularComponentcytoplasmic periphery of the nuclear pore complex

RGPD4 RGPD8 RGPD3

1.66e-068663GO:1990723
GeneOntologyCellularComponentnuclear pore cytoplasmic filaments

RGPD4 RGPD8 RGPD3

3.55e-0610663GO:0044614
GeneOntologyCellularComponentannulate lamellae

RGPD4 RGPD8 RGPD3

1.07e-0514663GO:0005642
GeneOntologyCellularComponentnuclear pore nuclear basket

RGPD4 RGPD8 RGPD3

2.37e-0518663GO:0044615
GeneOntologyCellularComponentnuclear inclusion body

RGPD4 RGPD8 RGPD3

3.30e-0520663GO:0042405
GeneOntologyCellularComponentSUMO ligase complex

RGPD4 RGPD8 RGPD3

3.84e-0521663GO:0106068
GeneOntologyCellularComponentinclusion body

RGPD4 RGPD8 AGL RGPD3

1.89e-0490664GO:0016234
GeneOntologyCellularComponentnuclear pore

RGPD4 RGPD8 RGPD3 RGPD5

2.94e-04101664GO:0005643
MousePhenoelevated level of mitotic sister chromatid exchange

RGPD4 RGPD8 RGPD3

1.58e-0516443MP:0003701
MousePhenoabnormal morula morphology

RGPD4 RGPD8 RGPD3

7.19e-0526443MP:0012058
MousePhenodecreased tumor latency

RGPD4 RGPD8 RGPD3

1.11e-0430443MP:0010308
MousePhenofailure of blastocyst formation

RGPD4 RGPD8 RGPD3

1.23e-0431443MP:0012129
MousePhenoabnormal tumor latency

RGPD4 RGPD8 RGPD3

1.63e-0434443MP:0010307
DomainOlfact_rcpt

OR2T6 OR11H1 OR10G2 OR2T35 OR10AD1 OR2T1 OR2D2 OR5K3 OR2Z1 OR11H12 OR5K1 OR11H2

7.81e-093936412IPR000725
DomainGrip

RGPD4 RGPD8 RGPD3 RGPD5

4.06e-0811644SM00755
DomainGRIP

RGPD4 RGPD8 RGPD3 RGPD5

4.06e-0811644PF01465
DomainRan_BP1

RGPD4 RGPD8 RGPD3 RGPD5

6.08e-0812644PF00638
DomainGRIP_dom

RGPD4 RGPD8 RGPD3 RGPD5

6.08e-0812644IPR000237
DomainGRIP

RGPD4 RGPD8 RGPD3 RGPD5

6.08e-0812644PS50913
DomainRANBD1

RGPD4 RGPD8 RGPD3 RGPD5

6.08e-0812644PS50196
DomainRanBD

RGPD4 RGPD8 RGPD3 RGPD5

8.76e-0813644SM00160
DomainRan_bind_dom

RGPD4 RGPD8 RGPD3 RGPD5

8.76e-0813644IPR000156
DomainGPCR_Rhodpsn_7TM

OR2T6 TRHR OR11H1 OR10G2 OR2T35 OR10AD1 OR2T1 OR2D2 OR5K3 OR2Z1 OR11H12 OR5K1 OR11H2

3.53e-076706413IPR017452
DomainG_PROTEIN_RECEP_F1_2

OR2T6 TRHR OR11H1 OR10G2 OR2T35 OR10AD1 OR2T1 OR2D2 OR5K3 OR2Z1 OR11H12 OR5K1 OR11H2

5.01e-076916413PS50262
DomainGPCR_Rhodpsn

OR2T6 TRHR OR11H1 OR10G2 OR2T35 OR10AD1 OR2T1 OR2D2 OR5K3 OR2Z1 OR11H12 OR5K1 OR11H2

5.09e-076926413IPR000276
DomainGCC2_Rab_bind

RGPD4 RGPD8 RGPD3

1.33e-067643IPR032023
DomainRab_bind

RGPD4 RGPD8 RGPD3

1.33e-067643PF16704
Domain7tm_1

OR2T6 TRHR OR11H1 OR10G2 OR2T35 OR10AD1 OR2T1 OR2D2 OR5K3 OR2Z1 OR11H12 OR5K1

2.72e-066776412PF00001
DomainG_PROTEIN_RECEP_F1_1

OR2T6 TRHR OR11H1 OR10G2 OR2T35 OR10AD1 OR2T1 OR2D2 OR5K3 OR2Z1 OR11H12 OR5K1

3.07e-066856412PS00237
Domain-

RGPD4 RGPD8 RGPD3

4.53e-06106431.10.220.60
DomainPH_dom-like

RGPD4 RGPD8 RASA1 RGPD3 ARHGEF3 CDC42BPB PREX1 RGPD5

9.93e-05426648IPR011993
Domain-

RGPD4 RGPD8 RASA1 RGPD3 ARHGEF3 CDC42BPB PREX1

3.72e-043916472.30.29.30
DomainAMP-bd_C

SLC27A5 SLC27A4

1.52e-0317642IPR025110
DomainAMP-binding_C

SLC27A5 SLC27A4

1.52e-0317642PF13193
DomainTPR-contain_dom

RGPD4 RGPD8 RGPD3 RGPD5

1.75e-03150644IPR013026
DomainTPR_REGION

RGPD4 RGPD8 RGPD3 RGPD5

2.47e-03165644PS50293
DomainTPR

RGPD4 RGPD8 RGPD3 RGPD5

2.47e-03165644PS50005
DomainAMP-binding_CS

SLC27A5 SLC27A4

3.56e-0326642IPR020845
DomainAMP_BINDING

SLC27A5 SLC27A4

4.13e-0328642PS00455
DomainAMP-binding

SLC27A5 SLC27A4

4.73e-0330642PF00501
DomainAMP-dep_Synth/Lig

SLC27A5 SLC27A4

4.73e-0330642IPR000873
DomainMFS_sugar_transport-like

SLC22A15 SLC2A4

6.76e-0336642IPR005828
DomainSugar_tr

SLC22A15 SLC2A4

6.76e-0336642PF00083
DomainPH

RASA1 ARHGEF3 CDC42BPB PREX1

7.88e-03229644PF00169
DomainGDS_CDC24_CS

ARHGEF3 PREX1

7.89e-0339642IPR001331
DomainTPR-like_helical_dom

RGPD4 RGPD8 RGPD3 RGPD5

8.36e-03233644IPR011990
PathwayREACTOME_OLFACTORY_SIGNALING_PATHWAY

OR5AC1 OR2T6 OR11H1 OR10G2 OR2T35 OR10AD1 OR2T1 OR2D2 OR5K3 OR2Z1 OR5K1 OR11H2

1.31e-084174912M4072
PathwayREACTOME_SENSORY_PERCEPTION

OR5AC1 OR2T6 OR11H1 OR10G2 OR2T35 OR10AD1 OR2T1 OR2D2 OR5K3 OR2Z1 OR5K1 OR11H2

1.27e-066364912M41834
PathwayREACTOME_GENE_SILENCING_BY_RNA

RGPD4 AGO4 RGPD8 RGPD3

2.43e-0549494MM14837
PathwayBIOCARTA_RANBP2_PATHWAY

RGPD4 RGPD8 RGPD3

3.10e-0518493MM1549
PathwayKEGG_OLFACTORY_TRANSDUCTION

OR2T6 OR11H1 OR10G2 OR10AD1 OR2T1 OR2D2 OR2Z1 OR5K1

5.24e-05389498M14091
PathwayREACTOME_NUCLEAR_PORE_COMPLEX_NPC_DISASSEMBLY

RGPD4 RGPD8 RGPD3

3.56e-0440493MM14945
PathwayREACTOME_TRANSCRIPTIONAL_REGULATION_BY_SMALL_RNAS

RGPD4 RGPD8 RGPD3

3.83e-0441493MM15200
PathwayREACTOME_SUMOYLATION_OF_SUMOYLATION_PROTEINS

RGPD4 RGPD8 RGPD3

4.12e-0442493MM15039
PathwayREACTOME_TRANSPORT_OF_THE_SLBP_DEPENDANT_MATURE_MRNA

RGPD4 RGPD8 RGPD3

4.42e-0443493MM14609
PathwayREACTOME_SUMOYLATION_OF_UBIQUITINYLATION_PROTEINS

RGPD4 RGPD8 RGPD3

5.75e-0447493MM14939
PathwayREACTOME_TRANSPORT_OF_MATURE_MRNAS_DERIVED_FROM_INTRONLESS_TRANSCRIPTS

RGPD4 RGPD8 RGPD3

6.90e-0450493MM14610
PathwayREACTOME_SUMOYLATION_OF_DNA_REPLICATION_PROTEINS

RGPD4 RGPD8 RGPD3

7.31e-0451493MM15151
PathwayREACTOME_NUCLEAR_ENVELOPE_BREAKDOWN

RGPD4 RGPD8 RGPD3

9.12e-0455493MM14917
PathwayREACTOME_RHOJ_GTPASE_CYCLE

ARHGAP32 CDC42BPB PREX1

9.12e-0455493M41815
PathwayREACTOME_SUMOYLATION_OF_RNA_BINDING_PROTEINS

RGPD4 RGPD8 RGPD3

1.06e-0358493MM15149
PathwayREACTOME_SNRNP_ASSEMBLY

RGPD4 RGPD8 RGPD3

1.06e-0358493MM14736
PathwayREACTOME_RHOQ_GTPASE_CYCLE

ARHGAP32 CDC42BPB PREX1

1.06e-0358493MM15602
PathwayREACTOME_RHOQ_GTPASE_CYCLE

ARHGAP32 CDC42BPB PREX1

1.12e-0359493M41812
PathwayKEGG_MEDICUS_REFERENCE_AUTOPHAGOSOME_AND_LYSOSOME_FUSION_TETHERING_FACTOR

TECPR2 VPS16

1.38e-0316492M47978
PathwayREACTOME_RHOJ_GTPASE_CYCLE

ARHGAP32 PREX1

1.38e-0316492MM15605
PathwayREACTOME_SUMOYLATION_OF_CHROMATIN_ORGANIZATION_PROTEINS

RGPD4 RGPD8 RGPD3

1.48e-0365493MM15147
Pubmed

Complex genomic rearrangements lead to novel primate gene function.

RGPD4 RGPD8 RGPD3 RGPD5

4.38e-10767415710750
Pubmed

Different evolutionary processes shaped the mouse and human olfactory receptor gene families.

OR5AC1 OR2T6 OR10G2 OR2T35 OR10AD1 OR2T1 OR2D2 OR5K3 OR2Z1 OR5K1

1.06e-09340671011875048
Pubmed

The olfactory receptor gene superfamily of the mouse.

OR5AC1 OR2T6 OR10G2 OR2T35 OR10AD1 OR2T1 OR2D2 OR5K3 OR2Z1 OR5K1

1.06e-09340671011802173
Pubmed

A unified nomenclature for vertebrate olfactory receptors.

OR5AC1 OR2T6 OR10G2 OR2T35 OR10AD1 OR2T1 OR2D2 OR5K3 OR2Z1 OR5K1

1.15e-09343671032295537
Pubmed

Odorant receptor expressed sequence tags demonstrate olfactory expression of over 400 genes, extensive alternate splicing and unequal expression levels.

OR5AC1 OR2T6 OR10G2 OR2T35 OR10AD1 OR2T1 OR2D2 OR5K3 OR2Z1 OR5K1

1.25e-09346671014611657
Pubmed

The human olfactory receptor gene family.

OR5AC1 OR11H1 OR10G2 OR2T35 OR10AD1 OR2T1 OR2D2 OR2Z1 OR5K1 OR11H2

8.56e-08541671014983052
Pubmed

Microglial activation in an amyotrophic lateral sclerosis-like model caused by Ranbp2 loss and nucleocytoplasmic transport impairment in retinal ganglion neurons.

RGPD4 RGPD8 RGPD3

2.38e-07767330944974
Pubmed

Nucleoporin Nup358 drives the differentiation of myeloid-biased multipotent progenitors by modulating HDAC3 nuclear translocation.

RGPD4 RGPD8 RGPD3

2.38e-07767338838144
Pubmed

Nup358, a nucleoporin, functions as a key determinant of the nuclear pore complex structure remodeling during skeletal myogenesis.

RGPD4 RGPD8 RGPD3

2.38e-07767321205196
Pubmed

Haploinsufficiency of RanBP2 is neuroprotective against light-elicited and age-dependent degeneration of photoreceptor neurons.

RGPD4 RGPD8 RGPD3

2.38e-07767318949001
Pubmed

Selective impairment of a subset of Ran-GTP-binding domains of ran-binding protein 2 (Ranbp2) suffices to recapitulate the degeneration of the retinal pigment epithelium (RPE) triggered by Ranbp2 ablation.

RGPD4 RGPD8 RGPD3

2.38e-07767325187515
Pubmed

Interconversion of red opsin isoforms by the cyclophilin-related chaperone protein Ran-binding protein 2.

RGPD4 RGPD8 RGPD3

2.38e-0776739037092
Pubmed

Kinesin-1 and mitochondrial motility control by discrimination of structurally equivalent but distinct subdomains in Ran-GTP-binding domains of Ran-binding protein 2.

RGPD4 RGPD8 RGPD3

2.38e-07767323536549
Pubmed

Localization of the Ran-GTP binding protein RanBP2 at the cytoplasmic side of the nuclear pore complex.

RGPD4 RGPD8 RGPD3

2.38e-0776738603673
Pubmed

Retina-specifically expressed novel subtypes of bovine cyclophilin.

RGPD4 RGPD8 RGPD3

2.38e-0776737559465
Pubmed

Uncoupling phototoxicity-elicited neural dysmorphology and death by insidious function and selective impairment of Ran-binding protein 2 (Ranbp2).

RGPD4 RGPD8 RGPD3

2.38e-07767326632511
Pubmed

Mst1, RanBP2 and eIF4G are new markers for in vivo PI3K activation in murine and human prostate.

RGPD4 RGPD8 RGPD3

2.38e-07767317372272
Pubmed

Differential loss of prolyl isomerase or chaperone activity of Ran-binding protein 2 (Ranbp2) unveils distinct physiological roles of its cyclophilin domain in proteostasis.

RGPD4 RGPD8 RGPD3

2.38e-07767324403063
Pubmed

Distinct and atypical intrinsic and extrinsic cell death pathways between photoreceptor cell types upon specific ablation of Ranbp2 in cone photoreceptors.

RGPD4 RGPD8 RGPD3

2.38e-07767323818861
Pubmed

Proteostatic Remodeling of Small Heat Shock Chaperones─Crystallins by Ran-Binding Protein 2─and the Peptidyl-Prolyl cis-trans Isomerase and Chaperone Activities of Its Cyclophilin Domain.

RGPD4 RGPD8 RGPD3

2.38e-07767338657106
Pubmed

Genomic organization, expression, and localization of murine Ran-binding protein 2 (RanBP2) gene.

RGPD4 RGPD8 RGPD3

2.38e-07767311353387
Pubmed

Identification of RanBP2- and kinesin-mediated transport pathways with restricted neuronal and subcellular localization.

RGPD4 RGPD8 RGPD3

2.38e-07767312191015
Pubmed

Ranbp2 haploinsufficiency mediates distinct cellular and biochemical phenotypes in brain and retinal dopaminergic and glia cells elicited by the Parkinsonian neurotoxin, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).

RGPD4 RGPD8 RGPD3

2.38e-07767322821000
Pubmed

Neuroprotection resulting from insufficiency of RANBP2 is associated with the modulation of protein and lipid homeostasis of functionally diverse but linked pathways in response to oxidative stress.

RGPD4 RGPD8 RGPD3

2.38e-07767320682751
Pubmed

The distribution of phosphorylated SR proteins and alternative splicing are regulated by RANBP2.

RGPD4 RGPD8 RGPD3

3.80e-07867322262462
Pubmed

The nucleoporin RanBP2 tethers the cAMP effector Epac1 and inhibits its catalytic activity.

RGPD4 RGPD8 RGPD3

3.80e-07867321670213
Pubmed

Zap70 and downstream RanBP2 are required for the exact timing of the meiotic cell cycle in oocytes.

RGPD4 RGPD8 RGPD3

3.80e-07867328745977
Pubmed

Critical role of RanBP2-mediated SUMOylation of Small Heterodimer Partner in maintaining bile acid homeostasis.

RGPD4 RGPD8 RGPD3

3.80e-07867327412403
Pubmed

Mice lacking Ran binding protein 1 are viable and show male infertility.

RGPD4 RGPD8 RGPD3

3.80e-07867321310149
Pubmed

The cyclophilin-like domain mediates the association of Ran-binding protein 2 with subunits of the 19 S regulatory complex of the proteasome.

RGPD4 RGPD8 RGPD3

5.69e-0796739733766
Pubmed

Loss of Ranbp2 in motoneurons causes disruption of nucleocytoplasmic and chemokine signaling, proteostasis of hnRNPH3 and Mmp28, and development of amyotrophic lateral sclerosis-like syndromes.

RGPD4 RGPD8 RGPD3

5.69e-07967328100513
Pubmed

Resolution of sister centromeres requires RanBP2-mediated SUMOylation of topoisomerase IIalpha.

RGPD4 RGPD8 RGPD3

5.69e-07967318394993
Pubmed

Impairments in age-dependent ubiquitin proteostasis and structural integrity of selective neurons by uncoupling Ran GTPase from the Ran-binding domain 3 of Ranbp2 and identification of novel mitochondrial isoforms of ubiquitin-conjugating enzyme E2I (ubc9) and Ranbp2.

RGPD4 RGPD8 RGPD3

5.69e-07967328877029
Pubmed

The docking of kinesins, KIF5B and KIF5C, to Ran-binding protein 2 (RanBP2) is mediated via a novel RanBP2 domain.

RGPD4 RGPD8 RGPD3

5.69e-07967311553612
Pubmed

Association of the kinesin-binding domain of RanBP2 to KIF5B and KIF5C determines mitochondria localization and function.

RGPD4 RGPD8 RGPD3

5.69e-07967317887960
Pubmed

The zinc finger cluster domain of RanBP2 is a specific docking site for the nuclear export factor, exportin-1.

RGPD4 RGPD8 RGPD3

5.69e-07967310601307
Pubmed

The RanBP2/RanGAP1*SUMO1/Ubc9 SUMO E3 ligase is a disassembly machine for Crm1-dependent nuclear export complexes.

RGPD4 RGPD8 RGPD3

8.12e-071067327160050
Pubmed

Parkin ubiquitinates and promotes the degradation of RanBP2.

RGPD4 RGPD8 RGPD3

8.12e-071067316332688
Pubmed

Cyclophilin-related protein RanBP2 acts as chaperone for red/green opsin.

RGPD4 RGPD8 RGPD3

8.12e-07106738857542
Pubmed

Ran-dependent docking of importin-beta to RanBP2/Nup358 filaments is essential for protein import and cell viability.

RGPD4 RGPD8 RGPD3

8.12e-071067321859863
Pubmed

An Rtn4/Nogo-A-interacting micropeptide modulates synaptic plasticity with age.

RGPD4 RGPD8 RGPD3

1.12e-061167335771867
Pubmed

RanBP2 modulates Cox11 and hexokinase I activities and haploinsufficiency of RanBP2 causes deficits in glucose metabolism.

RGPD4 RGPD8 RGPD3

1.12e-061167317069463
Pubmed

T-cell receptor (TCR) signaling promotes the assembly of RanBP2/RanGAP1-SUMO1/Ubc9 nuclear pore subcomplex via PKC-θ-mediated phosphorylation of RanGAP1.

RGPD4 RGPD8 RGPD3

1.12e-061167334110283
Pubmed

Ankyrin-G induces nucleoporin Nup358 to associate with the axon initial segment of neurons.

RGPD4 RGPD8 RGPD3

1.93e-061367331427429
Pubmed

Large-scale cDNA transfection screening for genes related to cancer development and progression.

GDPD5 YIPF5 ORAI2 NT5DC1 WDR59

2.84e-0611467515498874
Pubmed

Limited expression of nuclear pore membrane glycoprotein 210 in cell lines and tissues suggests cell-type specific nuclear pores in metazoans.

RGPD4 RGPD8 RGPD3

3.06e-061567314697343
Pubmed

Identification of P-Rex1 as a novel Rac1-guanine nucleotide exchange factor (GEF) that promotes actin remodeling and GLUT4 protein trafficking in adipocytes.

PREX1 SLC2A4

3.66e-06267222002247
Pubmed

DNA Methylation Signatures of Depressive Symptoms in Middle-aged and Elderly Persons: Meta-analysis of Multiethnic Epigenome-wide Studies.

ARHGEF3 CDC42BPB

3.66e-06267229998287
Pubmed

DEFOG: a practical scheme for deciphering families of genes.

OR2T6 OR11H1 OR10AD1 OR2T1 OR2D2 OR2Z1

4.22e-0621967612213199
Pubmed

Terminal differentiation of cortical neurons rapidly remodels RanGAP-mediated nuclear transport system.

RGPD4 RGPD8 RGPD3

1.03e-052267327717094
Pubmed

Identification of a novel Ran binding protein 2 related gene (RANBP2L1) and detection of a gene cluster on human chromosome 2q11-q12.

RGPD8 RGPD5

2.19e-0546729480752
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

ARHGAP32 LPGAT1 MAGI3 MORC2 CDC42BPB PREX1 WDR59

4.60e-0549367715368895
Pubmed

A family of fatty acid transporters conserved from mycobacterium to man.

SLC27A5 SLC27A4

5.46e-0566729671728
Pubmed

Peering through the pore: nuclear pore complex structure, assembly, and function.

RGPD4 RGPD8 RGPD3

5.49e-053867312791264
Pubmed

Differential expression of fatty acid transport proteins in epidermis and skin appendages.

SLC27A5 SLC27A4

7.63e-05767216354187
Pubmed

X-linked adrenoleukodystrophy: role of very long-chain acyl-CoA synthetases.

SLC27A5 SLC27A4

1.02e-04867215464426
Pubmed

C9orf72 protein quality control by UBR5-mediated heterotypic ubiquitin chains.

RGPD4 YIPF5 RGPD8 AGL TIMM23B PSMA4 RGPD3 PIPSL SLC27A4 RGPD5

1.40e-041257671037317656
Pubmed

The expression and function of fatty acid transport protein-2 and -4 in the murine placenta.

SLC27A5 SLC27A4

2.38e-041267222028793
Pubmed

Interactome profiling reveals interaction of SARS-CoV-2 NSP13 with host factor STAT1 to suppress interferon signaling.

YIPF5 RPAP1 TIMM23B SLC27A4

3.04e-0416667434687317
Pubmed

Ligand-activated peroxisome proliferator activated receptor gamma alters placental morphology and placental fatty acid uptake in mice.

SLC27A5 SLC27A4

3.28e-041467217463056
Pubmed

Odorant and vomeronasal receptor genes in two mouse genome assemblies.

OR5AC1 OR2T35 OR2Z1

4.02e-047467315081110
Pubmed

The ubiquitin ligase Uhrf2 is a master regulator of cholesterol biosynthesis and is essential for liver regeneration.

RGPD4 RGPD8 RGPD3

6.24e-048667337253089
Pubmed

RSPO-LGR4 functions via IQGAP1 to potentiate Wnt signaling.

RGPD4 DNAJC13 AGL CDC42BPB

6.36e-0420267424639526
Pubmed

Systematic proteomics of the VCP-UBXD adaptor network identifies a role for UBXN10 in regulating ciliogenesis.

YIPF5 CDC42BPB WDR59 SLC27A4

7.22e-0420967426389662
Pubmed

Proximity labeling of endogenous RICTOR identifies mTOR complex 2 regulation by ADP ribosylation factor ARF1.

RGPD4 RGPD8 RGPD3 RGPD5

8.03e-0421567435973513
Pubmed

Genetic variability of the fatty acid synthase pathway is not associated with prostate cancer risk in the European Prospective Investigation on Cancer (EPIC).

SLC2A4 SLC27A4

8.24e-042267220965718
Pubmed

Co-adaptor driven assembly of a CUL3 E3 ligase complex.

AGL ENC1

8.24e-042267235120648
Pubmed

Insights into specificity, redundancy and new cellular functions of C/EBPa and C/EBPb transcription factors through interactome network analysis.

RGPD4 RGPD8 RGPD3

9.39e-049967327746211
Pubmed

Nutrient Transporter Gene Expression in the Early Conceptus-Implications From Two Mouse Models of Diabetic Pregnancy.

SLC27A5 SLC27A4

1.07e-032567235478964
Pubmed

The endolysosomal adaptor PLEKHM1 is a direct target for both mTOR and MAPK pathways.

VPS16 WDR59

1.86e-033367233452816
Pubmed

Integral and associated lysosomal membrane proteins.

SLC29A3 DNAJC13 VPS16

1.88e-0312667317897319
InteractionRGPD4 interactions

RGPD4 RGPD8 RGPD3 RGPD5

4.05e-0722574int:RGPD4
InteractionRGPD2 interactions

RGPD4 RGPD8 RGPD3 RGPD5

9.61e-0727574int:RGPD2
InteractionRGPD3 interactions

RGPD4 RGPD8 RGPD3 RGPD5

9.37e-0647574int:RGPD3
InteractionRGPD1 interactions

RGPD4 RGPD8 RGPD3 RGPD5

1.11e-0549574int:RGPD1
InteractionAKIRIN2 interactions

RGPD8 PSMA4 RGPD3 RGPD5

5.71e-0574574int:AKIRIN2
InteractionRGPD8 interactions

RGPD4 RGPD8 RGPD3 RGPD5

5.71e-0574574int:RGPD8
InteractionASPSCR1 interactions

AGL PIPSL PREX1 SLC2A4

1.17e-0489574int:ASPSCR1
InteractionRGPD5 interactions

RGPD4 RGPD8 RGPD3 RGPD5

1.57e-0496574int:RGPD5
CytobandEnsembl 112 genes in cytogenetic band chr3q11

OR5AC1 OR5K3 OR5K1

6.99e-0554673chr3q11
Cytoband2q13

RGPD8 RGPD3 RGPD5

1.39e-04686732q13
Cytoband14q11.2

CPNE6 OR10G2 OR11H12 OR11H2

1.44e-0418067414q11.2
Cytoband1q44

OR2T6 OR2T35 OR2T1

5.73e-041106731q44
Cytoband3q11.2

OR5AC1 OR5K1

6.67e-04266723q11.2
CytobandEnsembl 112 genes in cytogenetic band chr1q44

OR2T6 OR2T35 OR2T1

8.90e-04128673chr1q44
CytobandEnsembl 112 genes in cytogenetic band chr14q11

CPNE6 OR10G2 OR11H12 OR11H2

1.44e-03332674chr14q11
GeneFamilyOlfactory receptors, family 2

OR2T6 OR2T35 OR2T1 OR2D2 OR2Z1

1.48e-05113505149
GeneFamilyOlfactory receptors, family 11

OR11H1 OR11H12 OR11H2

3.39e-0523503159
GeneFamilyTetratricopeptide repeat domain containing|Bardet-Biedl syndrome associated|BBSome

RGPD4 RGPD8 RGPD3 RGPD5

2.85e-04115504769
GeneFamilySolute carriers

SLC29A3 SLC25A43 SLC22A15 SLC2A4 SLC27A5 SLC27A4

7.38e-04395506752
GeneFamilyAcyl-CoA synthetase family

SLC27A5 SLC27A4

2.33e-032650240
GeneFamilyOlfactory receptors, family 5

OR5AC1 OR5K3 OR5K1

3.67e-03112503152
Diseaseinosine-5'-monophosphate dehydrogenase 2 measurement

TECPR2 ARHGEF3

3.41e-062552EFO_0008159
Diseaseinosine-5'-monophosphate dehydrogenase 1 measurement

TECPR2 ARHGEF3

2.04e-054552EFO_0008158
DiseaseSpastic Paraplegia, Hereditary

TECPR2 CYP2U1

3.06e-0414552C0037773
DiseaseNoonan-Like Syndrome With Loose Anagen Hair

RASA1 A2ML1

5.72e-0419552C3501846
DiseaseCostello syndrome (disorder)

RASA1 A2ML1

5.72e-0419552C0587248
Diseaseinferior parietal cortex volume measurement

GRIK1 NT5DC1

5.72e-0419552EFO_0010307
DiseaseNoonan syndrome-like disorder with loose anagen hair

RASA1 A2ML1

5.72e-0419552C1843181
DiseaseCardio-facio-cutaneous syndrome

RASA1 A2ML1

5.72e-0419552C1275081
DiseaseLEOPARD Syndrome

RASA1 A2ML1

7.69e-0422552C0175704
DiseaseNoonan Syndrome

RASA1 A2ML1

9.17e-0424552C0028326
Diseaseazoospermia (implicated_via_orthology)

YIPF5 CDC42BPB

1.16e-0327552DOID:14227 (implicated_via_orthology)

Protein segments in the cluster

PeptideGeneStartEntry
CYQLYRQPIPVKDLL

ARHGEF3

371

Q9NR81
LLYFLCYILPQTAPQ

GRIK1

21

P39086
GCVYVQTVLRYNILP

A2ML1

1306

A8K2U0
YSLQLKYPHLPCLQV

AGO4

306

Q9HCK5
SYRRCLPQIQLYGPT

CPNE6

396

O95741
LPPTLRYIYGCLQKS

RASA1

866

P20936
LAALCYLIAFQVPRP

RGPD5

316

Q99666
LAALCYLIAFQVPRP

RGPD8

316

O14715
QYQYPRPLLIAFSAC

ORAI2

86

Q96SN7
DQYLAICRPLLYPNI

OR11H2

136

Q8NH07
AICYPLNYVPIISQK

OR10AD1

126

Q8NGE0
DRYVAICNPLRYPVL

OR2T1

171

O43869
LCRYNLPESAPLIYN

NT5DC1

21

Q5TFE4
VAIPSYICYVIILQP

LPGAT1

31

Q92604
PVNQYVNLTLCRGYP

MAGI3

481

Q5TCQ9
PFCPESPRYLYIIQN

SLC2A4

221

P14672
DRYVAICNPLRYPVL

OR2T6

121

Q8NHC8
DRYVAVCQPLQYPVL

OR2Z1

121

Q8NG97
PLQYYEPQLCLSCLT

GDPD5

6

Q8WTR4
QLPPICYNYEIRIQC

MUC5AC

1656

P98088
VLPLYRLSCINPYIN

OR5K3

181

A6NET4
TLNLLNCEPPRLIYF

CDC42BPB

1511

Q9Y5S2
DRYVAVCNPLRYPLL

OR2T35

121

Q8NGX2
CKLYFRELPNPLLTY

ARHGAP32

446

A7KAX9
RDPNIYCLYPILESQ

DPRX

156

A6NFQ7
ILPLYRLSCVDPYIN

OR5K1

181

Q8NHB7
PRTLLPKFYGLYCVQ

PIPSL

166

A2A3N6
LVQILRNCLRYFLPP

MORC2

911

Q9Y6X9
DRYVAICNPLRYPNI

OR2D2

121

Q9H210
DRYVAICNPLLYPVV

OR5AC1

121

P0C628
LAALCYLIAFQVPRP

RGPD3

316

A6NKT7
QVLLVNICPWLYYLP

CYP2U1

266

Q7Z449
IYQCQIYRSLLALPQ

CLDN14

61

O95500
LQSNTRALYQYCPIP

DNAJC13

1226

O75165
INISIVYRYPPICLG

ERVK-5

41

Q9HDB8
YCYLPELLQTVRLAL

ENC1

226

O14682
YLYVPLNGSQPIRCR

FAM221A

111

A4D161
IEIPSYPLCIYLINQ

SLC22A15

346

Q8IZD6
RYLLQYQEPIPCEQL

PSMA4

96

P25789
ARYRALCVPPNPILY

PTCHD3

256

Q3KNS1
DQYLAICRPLLYPNI

OR11H1

136

Q8NG94
DQYLAICRPLLYPNI

OR11H12

136

B2RN74
DRYLAICQPLRYPVL

OR10G2

126

Q8NGC3
PYPNLNIIQTYICKV

GPRASP1

1226

Q5JY77
RTCLIPLFVLCNYQP

SLC29A3

386

Q9BZD2
LAALCYLIAFQVPRP

RGPD4

316

Q7Z3J3
RICIYLNSAINPVIY

TRHR

306

P34981
CLTPRLSLQLYYIPV

PIK3R6

446

Q5UE93
YLLSPIQRICKYPLL

PREX1

191

Q8TCU6
KRICLYQNGYILSPL

SLC25A43

291

Q8WUT9
RLSPDQCRIVYLQYP

APEH

306

P13798
QCRIVYLQYPSLIPH

APEH

311

P13798
LLLQCQYSPKRGPYQ

TREML4

36

Q6UXN2
VQYIGELCRYLLNQP

SLC27A4

331

Q6P1M0
YVGELLRYLCNIPQQ

SLC27A5

381

Q9Y2P5
EAYLPNVNLPLCYKI

TBX22

361

Q9Y458
YYRLRKLPACEIQAP

THEMIS2

536

Q5TEJ8
RLYPLAIQICEYLRL

VPS16

461

Q9H269
VRYNDYIQPICLPFD

TMPRSS12

181

Q86WS5
REFCPLYYLLNAIPT

TECPR2

11

O15040
PLCPYLNVDPRYLVQ

TIMM23B

41

Q5SRD1
LYSQLPPLRQHYLQR

RPAP1

1366

Q9BWH6
NRYQLPIYCLSPPVN

UBTD1

111

Q9HAC8
QQLLVAYPCALLYGV

YIPF5

236

Q969M3
YRQPRKYLNILPCQV

WDR59

221

Q6PJI9
LVQLYGVCIQRKPLY

TXK

326

P42681
NIYPTVQYPLEVLCL

TTC37

231

Q6PGP7
KRYQCHYVLPPQLQL

WDR87

741

Q6ZQQ6
KQIPRYLIPCYFDAI

AGL

996

P35573