Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	DNA-binding transcription repressor activity, RNA polymerase II-specific	CC2D1B CC2D1A ZBTB16 PPARD ESRRA ARX	8.82e-05	320	46	6	GO:0001227
GeneOntologyMolecularFunction	DNA-binding transcription repressor activity	CC2D1B CC2D1A ZBTB16 PPARD ESRRA ARX	9.77e-05	326	46	6	GO:0001217
Domain	DM14	CC2D1B CC2D1A	5.42e-06	2	44	2	SM00685
Domain	DM14	CC2D1B CC2D1A	5.42e-06	2	44	2	IPR006608
Domain	DUF1605	DHX16 DQX1	7.21e-04	17	44	2	IPR011709
Domain	OB_NTP_bind	DHX16 DQX1	7.21e-04	17	44	2	PF07717
Domain	HA2	DHX16 DQX1	8.10e-04	18	44	2	PF04408
Domain	Helicase-assoc_dom	DHX16 DQX1	8.10e-04	18	44	2	IPR007502
Domain	HA2	DHX16 DQX1	8.10e-04	18	44	2	SM00847
Domain	ARM-type_fold	HIP1 IPO4 INF2 STAG3 EIF2B5	1.16e-03	339	44	5	IPR016024
Domain	Helicase_C	DHX16 DQX1 DDX28	2.10e-03	108	44	3	IPR001650
Domain	HELICASE_CTER	DHX16 DQX1 DDX28	2.15e-03	109	44	3	PS51194
Domain	HELICASE_ATP_BIND_1	DHX16 DQX1 DDX28	2.15e-03	109	44	3	PS51192
Domain	DEXDc	DHX16 DQX1 DDX28	2.15e-03	109	44	3	SM00487
Domain	Helicase_ATP-bd	DHX16 DQX1 DDX28	2.21e-03	110	44	3	IPR014001
Domain	C2	CC2D2A CC2D1B CC2D1A	3.62e-03	131	44	3	PF00168
Domain	C2	CC2D2A CC2D1B CC2D1A	4.10e-03	137	44	3	SM00239
Domain	C2	CC2D2A CC2D1B CC2D1A	4.54e-03	142	44	3	PS50004
Domain	-	CC2D2A CC2D1B CC2D1A	5.09e-03	148	44	3	2.60.40.150
Domain	zf-C4	PPARD ESRRA	5.26e-03	46	44	2	PF00105
Domain	NUCLEAR_REC_DBD_1	PPARD ESRRA	5.26e-03	46	44	2	PS00031
Domain	Znf_hrmn_rcpt	PPARD ESRRA	5.26e-03	46	44	2	IPR001628
Domain	Nuclear_hrmn_rcpt	PPARD ESRRA	5.26e-03	46	44	2	IPR001723
Domain	ZnF_C4	PPARD ESRRA	5.26e-03	46	44	2	SM00399
Domain	NUCLEAR_REC_DBD_2	PPARD ESRRA	5.26e-03	46	44	2	PS51030
Domain	-	PPARD ESRRA	5.48e-03	47	44	2	1.10.565.10
Domain	HOLI	PPARD ESRRA	5.71e-03	48	44	2	SM00430
Domain	Nucl_hrmn_rcpt_lig-bd	PPARD ESRRA	5.71e-03	48	44	2	IPR000536
Domain	Hormone_recep	PPARD ESRRA	5.71e-03	48	44	2	PF00104
Domain	C2_dom	CC2D2A CC2D1B CC2D1A	6.76e-03	164	44	3	IPR000008
Domain	-	DHX16 IFI44L MDN1 DQX1 DDX28 GFM2	7.70e-03	746	44	6	3.40.50.300
Domain	-	PPARD ESRRA	7.97e-03	57	44	2	3.30.50.10
Domain	Znf_NHR/GATA	PPARD ESRRA	8.25e-03	58	44	2	IPR013088
Pubmed	A directed protein interaction network for investigating intracellular signal transduction.	CEP70 NAP1L1 RMI1 CC2D1A HIP1 ZBTB16 SNAPC4 INF2 MATR3 FAM118B	1.69e-06	1124	46	10	21900206
Pubmed	Loss of the Intellectual Disability and Autism Gene Cc2d1a and Its Homolog Cc2d1b Differentially Affect Spatial Memory, Anxiety, and Hyperactivity.	CC2D1B CC2D1A	1.71e-06	2	46	2	29552027
Pubmed	The Drosophila Notch inhibitor and tumor suppressor gene lethal (2) giant discs encodes a conserved regulator of endosomal trafficking.	CC2D1B CC2D1A	1.71e-06	2	46	2	17084358
Pubmed	Male-Specific cAMP Signaling in the Hippocampus Controls Spatial Memory Deficits in a Mouse Model of Autism and Intellectual Disability.	CC2D1B CC2D1A	1.71e-06	2	46	2	30732858
Pubmed	The Freud-1/CC2D1A family: transcriptional regulators implicated in mental retardation.	CC2D1B CC2D1A	1.71e-06	2	46	2	17394259
Pubmed	Unravelling of Hidden Secrets: The Tumour Suppressor Lethal (2) Giant Discs (Lgd)/CC2D1, Notch Signalling and Cancer.	CC2D1B CC2D1A	1.71e-06	2	46	2	33034024
Pubmed	Positive association of CC2D1A and CC2D2A gene haplotypes with mental retardation in a Han Chinese population.	CC2D2A CC2D1A	1.71e-06	2	46	2	22023432
Pubmed	Freud-2/CC2D1B mediates dual repression of the serotonin-1A receptor gene.	CC2D1B CC2D1A	5.13e-06	3	46	2	21155902
Pubmed	CC2D1A and CC2D1B regulate degradation and signaling of EGFR and TLR4.	CC2D1B CC2D1A	1.03e-05	4	46	2	27769858
Pubmed	A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.	PEX19 NAP1L1 HIP1 IFI44L MDN1 IPO4 INF2 GFM2 MDC1 EIF2B5	1.50e-05	1440	46	10	30833792
Pubmed	Plasmacytoid dendritic cells delineate immunogenicity of influenza vaccine subtypes.	PYCARD IFNAR2	1.71e-05	5	46	2	20424013
Pubmed	High-fat diet enhances stemness and tumorigenicity of intestinal progenitors.	PPARD LGR5	1.71e-05	5	46	2	26935695
Pubmed	Heterozygous deletion of chromosome 17p renders prostate cancer vulnerable to inhibition of RNA polymerase II.	IPO4 CSRNP3 TUBAL3 MATR3 MDC1	1.77e-05	244	46	5	30349055
Pubmed	High-fat diet-activated fatty acid oxidation mediates intestinal stemness and tumorigenicity.	PPARD LGR5	2.56e-05	6	46	2	34107251
Pubmed	The Mammalian Orthologs of Drosophila Lgd, CC2D1A and CC2D1B, Function in the Endocytic Pathway, but Their Individual Loss of Function Does Not Affect Notch Signalling.	CC2D1B CC2D1A	2.56e-05	6	46	2	26720614
Pubmed	Systematic proteomics of endogenous human cohesin reveals an interaction with diverse splicing factors and RNA-binding proteins required for mitotic progression.	CEP70 USP13 MDN1 STAG3 MATR3	2.97e-05	272	46	5	31010829
Pubmed	Inflammasome-dependent IFN-γ drives pathogenesis in Streptococcus pneumoniae meningitis.	PYCARD IFNAR2	3.58e-05	7	46	2	23071286
Pubmed	USP13 regulates the RAP80-BRCA1 complex dependent DNA damage response.	USP13 MDC1	3.58e-05	7	46	2	28569838
Pubmed	ZMYM3 regulates BRCA1 localization at damaged chromatin to promote DNA repair.	NAP1L1 MDN1 MATR3 MDC1	4.71e-05	150	46	4	28242625
Pubmed	A systematic analysis of human CHMP protein interactions: additional MIT domain-containing proteins bind to multiple components of the human ESCRT III complex.	CC2D1A CHMP5 EIF2B5	6.03e-05	57	46	3	16730941
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	DHX16 MDN1 SNAPC4 ESRRA MATR3 MDC1 EIF2B5	6.62e-05	774	46	7	15302935
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	NAP1L1 DHX16 CC2D2A MDN1 IPO4 SYNE1 MATR3 MDC1 EIF2B5	8.88e-05	1425	46	9	30948266
Pubmed	Interleukin-33 Promotes Serotonin Release from Enterochromaffin Cells for Intestinal Homeostasis.	ZBTB16 LGR5	1.12e-04	12	46	2	33220232
Pubmed	FANCB is essential in the male germline and regulates H3K9 methylation on the sex chromosomes during meiosis.	ZBTB16 MDC1	1.54e-04	14	46	2	26123487
Pubmed	Functional screening of FxxLF-like peptide motifs identifies SMARCD1/BAF60a as an androgen receptor cofactor that modulates TMPRSS2 expression.	ZBTB16 MDN1	1.78e-04	15	46	2	19762545
Pubmed	Mammalian APE1 controls miRNA processing and its interactome is linked to cancer RNA metabolism.	NAP1L1 DHX16 CC2D1A IPO4 MATR3 EIF2B5 IFNAR2	1.99e-04	925	46	7	28986522
Pubmed	FADD and caspase-8 mediate priming and activation of the canonical and noncanonical Nlrp3 inflammasomes.	PYCARD IFNAR2	2.03e-04	16	46	2	24453255
Pubmed	USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma.	MDN1 SYNE1 MATR3 MDC1	2.61e-04	234	46	4	36243803
Pubmed	CAMK2D serves as a molecular scaffold for RNF8-MAD2 complex to induce mitotic checkpoint in glioma.	PEX19 MDN1 MDC1	2.67e-04	94	46	3	37468549
Pubmed	Hydroxypropyl-β-cyclodextrin spikes local inflammation that induces Th2 cell and T follicular helper cell responses to the coadministered antigen.	PYCARD IFNAR2	2.88e-04	19	46	2	25681338
Pubmed	Functional genomic landscape of cancer-intrinsic evasion of killing by T cells.	PEX19 PPP2R3C N6AMT1 TUBAL3 EIF2B5	3.37e-04	457	46	5	32968282
Pubmed	Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.	NAP1L1 DHX16 POLD4 USP13 MDN1 MATR3 MDC1	3.48e-04	1014	46	7	32416067
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	NAP1L1 DHX16 MDN1 IPO4 INF2 MATR3 MDC1 EIF2B5	3.59e-04	1353	46	8	29467282
Pubmed	A whole genome screen for HIV restriction factors.	RMI1 ESRRA CHMP5	4.01e-04	108	46	3	22082156
Pubmed	Nuclear actin interactome analysis links actin to KAT14 histone acetyl transferase and mRNA splicing.	NAP1L1 DHX16 INF2 CHMP5 MDC1	5.36e-04	506	46	5	30890647
Pubmed	Positioning of five genes (CASK, ARX, SAT, IMAGE cDNAs 248928 and 253949) from the human X chromosome short arm with respect to evolutionary breakpoints on the mouse X chromosome.	CDR1 ARX	5.45e-04	26	46	2	10920247
Pubmed	Comprehensive Proteomic Analysis of PGC7-Interacting Proteins.	IPO4 PPP2R3C MATR3 EIF2B5	5.64e-04	287	46	4	28712289
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	CC2D1A CRYBG2 HIP1 MDN1 SNAPC4 PPP2R3C INF2	5.81e-04	1105	46	7	35748872
Pubmed	SCML2 establishes the male germline epigenome through regulation of histone H2A ubiquitination.	ZBTB16 MDC1	5.88e-04	27	46	2	25703348
Pubmed	JMJD1C Exhibits Multiple Functions in Epigenetic Regulation during Spermatogenesis.	ZBTB16 MDC1	6.79e-04	29	46	2	27649575
Pubmed	TopBP1 controls BLM protein level to maintain genome stability.	RMI1 MDC1	6.79e-04	29	46	2	24239288
Pubmed	A High-Density Human Mitochondrial Proximity Interaction Network.	PEX19 MDN1 INF2 SYNE1 DDX28 GFM2 MATR3 CHMP5	6.98e-04	1496	46	8	32877691
Pubmed	Exchangeable gene trap using the Cre/mutated lox system.	NAP1L1 RMI1 HIP1 PPARD CSRNP3	7.06e-04	538	46	5	10512203
Pubmed	Systematic analysis of human protein complexes identifies chromosome segregation proteins.	DHX16 RMI1 PPP2R3C INF2 SYNE1 DDX28 MATR3	7.55e-04	1155	46	7	20360068
Pubmed	Interactions of the Antiviral Factor Interferon Gamma-Inducible Protein 16 (IFI16) Mediate Immune Signaling and Herpes Simplex Virus-1 Immunosuppression.	DHX16 INF2 SYNE1 DDX28	9.70e-04	332	46	4	25693804
Pubmed	Fine-scale comparative mapping of the human 7q11.23 region and the orthologous region on mouse chromosome 5G: the low-copy repeats that flank the Williams-Beuren syndrome deletion arose at breakpoint sites of an evolutionary inversion(s).	HIP1 STAG3	9.90e-04	35	46	2	11013070
Pubmed	HIV-1 Vpr induces cell cycle arrest and enhances viral gene expression by depleting CCDC137.	NAP1L1 MATR3 MDC1	1.00e-03	148	46	3	32538781
Pubmed	Genetic variants in inflammation-related genes are associated with radiation-induced toxicity following treatment for non-small cell lung cancer.	PPARD IFNAR2	1.05e-03	36	46	2	20811626
Pubmed	RUFY1 binds Arl8b and mediates endosome-to-TGN CI-M6PR retrieval for cargo sorting to lysosomes.	NAP1L1 IPO4 TUBAL3 MATR3	1.11e-03	344	46	4	36282215
Pubmed	A Large-scale genetic association study of esophageal adenocarcinoma risk.	DHX16 CAPN9 PPARD IFNAR2	1.19e-03	351	46	4	20453000
Cytoband	Ensembl 112 genes in cytogenetic band chr6p21	DHX16 LRFN2 PPARD MDC1	1.61e-03	503	46	4	chr6p21
Cytoband	1p32.3	CC2D1B TTC22	1.73e-03	61	46	2	1p32.3
Cytoband	1p36.33	B3GALT6 CFAP74	2.74e-03	77	46	2	1p36.33
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	CC2D1B CC2D1A	1.51e-03	36	29	2	823
GeneFamily	Nuclear hormone receptors	PPARD ESRRA	2.79e-03	49	29	2	71
Coexpression	GSE21033_CTRL_VS_POLYIC_STIM_DC_3H_DN	RMI1 BICDL1 SNAPC4 SYNE1 MDC1	2.55e-05	199	46	5	M7711
Coexpression	GSE2770_IL4_ACT_VS_ACT_CD4_TCELL_6H_DN	RMI1 HIP1 PPARD EIF2B5 IFNAR2	2.55e-05	199	46	5	M6119
ToppCell	COVID-19_Convalescent-Classical_Monocyte-cMono_4\|COVID-19_Convalescent / Disease condition and Cell class	PEX19 RMI1 USP13 IFI44L MDN1	1.13e-06	179	46	5	366e4a31db9e80fd1770ac9f1ae148fefeb9f7df
ToppCell	COVID-19_Convalescent-Classical_Monocyte-cMono_4\|Classical_Monocyte / Disease condition and Cell class	PEX19 RMI1 USP13 IFI44L MDN1	1.13e-06	179	46	5	9d51318ac198a8801bd5c7031ebf2b0c74ffeeb6
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell\|Severe-critical_progression_d12-22 / Compartment, severity and other cell annotations on 10x 3' data (130k)	NAP1L1 STAG3 SYNE1 MATR3	3.32e-05	177	46	4	64b8f665fdaf975558af2ad7d9b54d206de8350c
ToppCell	5'-Airway_Nasal-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell-Deuterosomal\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	NAP1L1 CC2D2A RMI1 USP13	3.47e-05	179	46	4	d15182c668d7c37be8214cad9f1fe35d1409c9a1
ToppCell	5'-Airway_Nasal-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell-Deuterosomal-Deuterosomal_L.0.3.4.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	NAP1L1 CC2D2A RMI1 USP13	3.47e-05	179	46	4	e22a275a7c0ed19113c833a75d6c49fcc19aa13a
ToppCell	Severe-B_naive-12\|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)	POLD4 IFI44L ZBTB16 STAG3	3.55e-05	180	46	4	bc20e581d37cba72b71ef62df60475a0ccee9994
ToppCell	droplet-Large_Intestine-COLON_PROXIMAL-30m-Epithelial-Lgr5+_undifferentiated_cell\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NAP1L1 CC2D2A LGR5 ARX	3.86e-05	184	46	4	e7b9c69fc77040c5191ad8089697051e2589c30e
Disease	intellectual disability (is_implicated_in)	CC2D2A CC2D1A	8.39e-04	30	42	2	DOID:1059 (is_implicated_in)
Disease	visceral heterotaxy (implicated_via_orthology)	CC2D2A CC2D1A	1.28e-03	37	42	2	DOID:0050545 (implicated_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
DAILDALENLTAEEL	PYCARD	6	Q9ULZ3
DDDSFARLDALLAEL	B3GALT6	156	Q96L58
IDFSNADIDVLEDLL	BPIFB4	596	P59827
EEEAELELLRQFDLA	POLD4	41	Q9HCU8
LEAELADEEFLFGDV	DHX16	246	O60231
ELELALEEELALLAA	BICDL1	51	Q6ZP65
LLEDVDLLEDTDFLE	CDR1	51	P51861
DLLEDTDFLEDLDFS	CDR1	56	P51861
LEDPDFLEAIDLRED	CDR1	106	P51861
DLDDDAEAILAADFE	NAP1L1	311	P55209
CSFLDDLLELRDEEL	PPP2R3C	246	Q969Q6
DDLEAELDALGDELL	CHMP5	161	Q9NZZ3
ELDALGDELLADEDS	CHMP5	166	Q9NZZ3
EDGFFLLDEISLADD	MDN1	1461	Q9NU22
DELLVDEEEAAALLE	MATR3	656	P43243
RLLLAEDSEEEVDFL	MDC1	161	Q14676
LRAADDFLEDLPLEE	IFI44L	426	Q53G44
LTLDDISDDDIDLDN	CSRNP3	151	Q8WYN3
DHLEALAAIEDFFLE	EIF2B5	641	Q13144
DEADTLLDESFLELV	DDX28	286	Q9NUL7
QALEDLDYLAALDDD	DQX1	441	Q8TE96
LEDADLLIQLEAFEE	INF2	236	Q27J81
FLRVLDDEDSDDLEA	IFNAR2	431	P48551
RELEELLESALDDFD	PEX19	16	P40855
EEELLNGDDAEDFLL	CC2D2A	241	Q9P2K1
NDLLEILEIDDLDAI	CEP70	571	Q8NHQ1
DEVALAADLEIFLDT	CRYBG2	756	Q8N1P7
DLEADDDLLAELNEV	CC2D1A	96	Q6P1N0
EAEDDEDLEAELLAL	CC2D1B	41	Q5T0F9
DDEEELLEDDARALL	ARX	246	Q96QS3
ALLDAAIDFDLLEDE	FAM118B	71	Q9BPY3
DEELQLDFDDFLNCL	CAPN9	641	O14815
QDELAFAEDLVLDEE	ESRRA	281	P11474
ACEALEALDELLESE	IPO4	221	Q8TEX9
DELLADALLLEDERD	CFAP74	11	Q9C0B2
DLEDFLLDFEEDLKA	LGR5	521	O75473
DLDDEFADLVLEEFS	GFM2	286	Q969S9
LELDDSDLALFIAAI	PPARD	341	Q03181
DLSDRELELEDSAAL	SYNE1	8221	Q8NF91
LDDFSLEEALLLEET	RMI1	311	Q9H9A7
AADDCEFLRAELDEL	HIP1	426	O00291
EEAEFLEAREDLAAL	TUBAL3	421	A6NHL2
AEDLDDLLYAAEILE	ZBTB16	96	Q05516
ELEELLQSSFLDEDE	STAG3	681	Q9UJ98
EDEDLLSELELADRD	SNAPC4	1401	Q5SXM2
AVADDLDALIDDLDY	TTC22	6	Q5TAA0
IFLDLDTDDDLNSDD	USP13	116	Q92995
DEAFEDFLLTLEDLD	LRFN2	141	Q9ULH4
AEDTFLLLDALEAAA	N6AMT1	26	Q9Y5N5