Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	adenylosuccinate synthase activity	ADSS2 ADSS1	1.59e-05	2	80	2	GO:0004019
GeneOntologyMolecularFunction	small GTPase binding	DOCK2 SYTL4 RAB3GAP2 DOCK10 GRIA1 RGP1 SOD1	3.02e-04	321	80	7	GO:0031267
GeneOntologyMolecularFunction	guanyl-nucleotide exchange factor activity	DOCK2 RAB3GAP2 DOCK10 HERC2 HERC1 RGP1	3.31e-04	231	80	6	GO:0005085
Domain	Adenylsucc_synt	ADSS2 ADSS1	1.86e-05	2	81	2	SM00788
Domain	Adenylsucc_synt	ADSS2 ADSS1	1.86e-05	2	81	2	PF00709
Domain	Adenylosuccin_syn_Lys_AS	ADSS2 ADSS1	1.86e-05	2	81	2	IPR033128
Domain	ADENYLOSUCCIN_SYN_2	ADSS2 ADSS1	1.86e-05	2	81	2	PS00513
Domain	Adenylosuccin_syn_GTP-bd	ADSS2 ADSS1	1.86e-05	2	81	2	IPR018220
Domain	Adenylosuccinate_synthetase	ADSS2 ADSS1	1.86e-05	2	81	2	IPR001114
Domain	ADENYLOSUCCIN_SYN_1	ADSS2 ADSS1	1.86e-05	2	81	2	PS01266
Domain	RCC1	HERC2 HERC1 HERC6	8.49e-05	20	81	3	PF00415
Domain	RCC1_1	HERC2 HERC1 HERC6	9.88e-05	21	81	3	PS00625
Domain	RCC1_2	HERC2 HERC1 HERC6	9.88e-05	21	81	3	PS00626
Domain	RCC1_3	HERC2 HERC1 HERC6	9.88e-05	21	81	3	PS50012
Domain	Reg_chr_condens	HERC2 HERC1 HERC6	1.14e-04	22	81	3	IPR000408
Domain	-	HERC2 HERC1 HERC6	1.14e-04	22	81	3	2.130.10.30
Domain	RCC1/BLIP-II	HERC2 HERC1 HERC6	1.31e-04	23	81	3	IPR009091
Domain	HECT	HERC2 HERC1 HERC6	2.13e-04	27	81	3	PF00632
Domain	HECTc	HERC2 HERC1 HERC6	2.13e-04	27	81	3	SM00119
Domain	HECT_dom	HERC2 HERC1 HERC6	2.13e-04	27	81	3	IPR000569
Domain	HECT	HERC2 HERC1 HERC6	2.13e-04	27	81	3	PS50237
Domain	DEAD/DEAH_box_helicase_dom	RECQL4 YTHDC2 MTREX DDX4	2.85e-04	73	81	4	IPR011545
Domain	DEAD	RECQL4 YTHDC2 MTREX DDX4	2.85e-04	73	81	4	PF00270
Domain	DOCK_C	DOCK2 DOCK10	9.96e-04	11	81	2	IPR010703
Domain	DHR-1_domain	DOCK2 DOCK10	9.96e-04	11	81	2	IPR027007
Domain	DHR_2	DOCK2 DOCK10	9.96e-04	11	81	2	PS51651
Domain	DHR_1	DOCK2 DOCK10	9.96e-04	11	81	2	PS51650
Domain	DOCK-C2	DOCK2 DOCK10	9.96e-04	11	81	2	PF14429
Domain	DHR-2	DOCK2 DOCK10	9.96e-04	11	81	2	IPR027357
Domain	DHR-2	DOCK2 DOCK10	9.96e-04	11	81	2	PF06920
Domain	DOCK	DOCK2 DOCK10	9.96e-04	11	81	2	IPR026791
Domain	P-loop_NTPase	ADSS2 SULT2B1 GET3 RECQL4 YTHDC2 MTREX FIGN GNL3 DDX4 KIF2C ADSS1	1.05e-03	848	81	11	IPR027417
Domain	Helicase_C	RECQL4 YTHDC2 MTREX DDX4	1.21e-03	107	81	4	PF00271
Domain	HELICc	RECQL4 YTHDC2 MTREX DDX4	1.21e-03	107	81	4	SM00490
Domain	Helicase_C	RECQL4 YTHDC2 MTREX DDX4	1.25e-03	108	81	4	IPR001650
Domain	HELICASE_CTER	RECQL4 YTHDC2 MTREX DDX4	1.29e-03	109	81	4	PS51194
Domain	HELICASE_ATP_BIND_1	RECQL4 YTHDC2 MTREX DDX4	1.29e-03	109	81	4	PS51192
Domain	DEXDc	RECQL4 YTHDC2 MTREX DDX4	1.29e-03	109	81	4	SM00487
Domain	WD_REPEATS_1	RRP9 PWP2 WDFY3 HERC2 HERC1 EIF2A	1.31e-03	278	81	6	PS00678
Domain	Helicase_ATP-bd	RECQL4 YTHDC2 MTREX DDX4	1.34e-03	110	81	4	IPR014001
Domain	WD_REPEATS_2	RRP9 PWP2 WDFY3 HERC2 HERC1 EIF2A	1.34e-03	279	81	6	PS50082
Domain	WD_REPEATS_REGION	RRP9 PWP2 WDFY3 HERC2 HERC1 EIF2A	1.34e-03	279	81	6	PS50294
Domain	WD40_repeat_dom	RRP9 PWP2 WDFY3 HERC1 EIF2A HPS5	1.84e-03	297	81	6	IPR017986
Domain	SH3	DOCK2 SH3PXD2A RUSC1 OTOR NOSTRIN	2.48e-03	216	81	5	SM00326
Domain	SH3	DOCK2 SH3PXD2A RUSC1 OTOR NOSTRIN	2.48e-03	216	81	5	PS50002
Domain	SH3_domain	DOCK2 SH3PXD2A RUSC1 OTOR NOSTRIN	2.69e-03	220	81	5	IPR001452
Domain	WD40/YVTN_repeat-like_dom	RRP9 PWP2 WDFY3 HERC1 EIF2A HPS5	3.34e-03	335	81	6	IPR015943
Domain	WD40_repeat_CS	RRP9 PWP2 WDFY3 HERC1	5.64e-03	164	81	4	IPR019775
Domain	WD40_repeat	RRP9 PWP2 WDFY3 HERC2 HERC1	6.58e-03	272	81	5	IPR001680
Domain	CNMP_BINDING_1	KCNH1 PRKG1	8.47e-03	32	81	2	PS00888
Domain	CNMP_BINDING_2	KCNH1 PRKG1	8.47e-03	32	81	2	PS00889
Pubmed	A High-Density Human Mitochondrial Proximity Interaction Network.	POTEE VRK2 HSDL2 VPS13C RRP9 FLAD1 RAB3GAP2 PWP2 PUM2 YTHDC2 HERC2 HERC1 GNL3 DDX4 KIF2C	1.97e-06	1496	82	15	32877691
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	POTEE VRK2 RRP9 PWP2 PALM3 PUM2 YTHDC2 CBX4 HERC2 MTREX PFKP EIF4G3 EIF2A GNL3 KIF2C	1.98e-06	1497	82	15	31527615
Pubmed	Functional reconstruction of NANOS3 expression in the germ cell lineage by a novel transgenic reporter reveals distinct subcellular localizations of NANOS3.	PUM2 EIF2A DDX4	2.74e-06	12	82	3	19861488
Pubmed	Defining the human deubiquitinating enzyme interaction landscape.	BLMH SYTL4 AMOT HMX3 GET3 PWP2 YTHDC2 HERC2 PFKP EIF4G3 USP48 OTUD7B	4.10e-06	1005	82	12	19615732
Pubmed	Mutation analysis of VSX1 and SOD1 in Iranian patients with keratoconus.	VSX1 SOD1	5.49e-06	2	82	2	22171159
Pubmed	Molecular cloning and expression of a mouse muscle cDNA encoding adenylosuccinate synthetase.	ADSS2 ADSS1	5.49e-06	2	82	2	1939273
Pubmed	Elevated Cu/Zn-SOD exacerbates radiation sensitivity and hematopoietic abnormalities of Atm-deficient mice.	ATM SOD1	5.49e-06	2	82	2	11285218
Pubmed	Variations in the response of mouse isozymes of adenylosuccinate synthetase to inhibitors of physiological relevance.	ADSS2 ADSS1	5.49e-06	2	82	2	12482871
Pubmed	Polymorphism Analysis of VSX1 and SOD1 Genes in Greek Patients with Keratoconus.	VSX1 SOD1	5.49e-06	2	82	2	24099280
Pubmed	Association analyses of the interaction between the ADSS and ATM genes with schizophrenia in a Chinese population.	ADSS2 ATM	5.49e-06	2	82	2	19115993
Pubmed	Cholesterol sulfate is a DOCK2 inhibitor that mediates tissue-specific immune evasion in the eye.	DOCK2 SULT2B1	5.49e-06	2	82	2	30065028
Pubmed	Molecular cloning and characterization of a novel muscle adenylosuccinate synthetase, AdSSL1, from human bone marrow stromal cells.	ADSS2 ADSS1	5.49e-06	2	82	2	15786719
Pubmed	Absence of pathogenic mutations in VSX1 and SOD1 genes in patients with keratoconus.	VSX1 SOD1	5.49e-06	2	82	2	20023586
Pubmed	Localization of a gene for keratoconus to a 5.6-Mb interval on 13q32.	VSX1 SOD1	5.49e-06	2	82	2	19011015
Pubmed	Cloning and characterization of the cDNA encoding human adenylosuccinate synthetase.	ADSS2 ADSS1	5.49e-06	2	82	2	1592113
Pubmed	Amplification of an adenylosuccinate synthetase gene in alanosine-resistant murine T-lymphoma cells. Molecular cloning of a cDNA encoding the "non-muscle" isozyme.	ADSS2 ADSS1	5.49e-06	2	82	2	8308018
Pubmed	Identification of a novel actin isoform in hepatocellular carcinoma.	POTEE POTEM POTEG	5.63e-06	15	82	3	16824795
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	CEP350 HIPK4 SH3PXD2A AMOT RAB3GAP2 CBX4 MTREX PFKP EIF4G3 PRRC1 KIF2C	5.68e-06	861	82	11	36931259
Pubmed	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.	AMOT RAB3GAP2 DOCK10 PUM2 WDFY3 HPS5	1.59e-05	225	82	6	12168954
Pubmed	Impaired genomic stability and increased oxidative stress exacerbate different features of Ataxia-telangiectasia.	ATM SOD1	1.64e-05	3	82	2	16150740
Pubmed	Mutational screening of VSX1, SPARC, SOD1, LOX, and TIMP3 in keratoconus.	VSX1 SOD1	1.64e-05	3	82	2	21976959
Pubmed	[Functional Hypermethylation of ALDH1L1, PLCL2, and PPP2R3A in Colon Cancer].	PLCL2 ALDH1L1	1.64e-05	3	82	2	32392189
Pubmed	Effect of the reduction of superoxide dismutase 1 and 2 or treatment with alpha-tocopherol on tumorigenesis in Atm-deficient mice.	ATM SOD1	1.64e-05	3	82	2	16863992
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	RRP9 PWP2 YTHDC2 ATM HERC2 MTREX PFKP EIF4G3 GNL3	2.38e-05	653	82	9	22586326
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	CEP350 BLMH AMOT RRP9 GET3 PWP2 YTHDC2 HERC2 MTREX PFKP GNL3	2.84e-05	1024	82	11	24711643
Pubmed	System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes.	HERC2 HERC1 HERC6	3.16e-05	26	82	3	26949039
Pubmed	Genetics and clinical characteristics of keratoconus.	VSX1 SOD1	3.28e-05	4	82	2	20664914
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	VRK2 HSDL2 RRP9 RAB3GAP2 PWP2 ATM HERC2 PFKP EIF4G3 EIF2A USP48 GNL3 SOD1	4.32e-05	1487	82	13	33957083
Pubmed	Human variation in alcohol response is influenced by variation in neuronal signaling genes.	DOCK2 DSPP KCNH1 QDPR SOD1	5.45e-05	171	82	5	20201926
Pubmed	Neurotransmission and bipolar disorder: a systematic family-based association study.	GRIA1 QDPR	5.47e-05	5	82	2	18444252
Pubmed	An Important Role of Pumilio 1 in Regulating the Development of the Mammalian Female Germline.	PUM2 DDX4	5.47e-05	5	82	2	27170441
Pubmed	ATM activation is impaired in human cells defective in RecQL4 helicase activity.	RECQL4 ATM	5.47e-05	5	82	2	30594395
Pubmed	The human HERC family of ubiquitin ligases: novel members, genomic organization, expression profiling, and evolutionary aspects.	HERC1 HERC6	5.47e-05	5	82	2	15676274
Pubmed	CYLD Regulates Centriolar Satellites Proteostasis by Counteracting the E3 Ligase MIB1.	CEP350 MGAM RUSC1 HERC2 MTREX	7.31e-05	182	82	5	31067453
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	BLMH TGM1 ADSS2 RECQL4 DOCK10 WDFY3 HERC2 MTREX PFKP EIF2A GNL3 KIF2C	7.66e-05	1353	82	12	29467282
Pubmed	Two novel transcripts encoding two Ankyrin repeat containing proteins have preponderant expression during the mouse spermatogenesis.	POTEM POTEG	8.19e-05	6	82	2	17171436
Pubmed	Hypoxia modulates the purine salvage pathway and decreases red blood cell and supernatant levels of hypoxanthine during refrigerated storage.	ADSS2 ADSS1	8.19e-05	6	82	2	29079593
Pubmed	WWP2 ubiquitylates RNA polymerase II for DNA-PK-dependent transcription arrest and repair at DNA breaks.	WBP2 AMOT RECQL4 PWP2 YTHDC2 MTREX GNL3 KIF2C	1.03e-04	615	82	8	31048545
Pubmed	Ptbp2 represses adult-specific splicing to regulate the generation of neuronal precursors in the embryonic brain.	CEP350 PUM2 ATM	1.09e-04	39	82	3	22802532
Pubmed	Five POTE paralogs and their splice variants are expressed in human prostate and encode proteins of different lengths.	POTEE POTEG	1.14e-04	7	82	2	15276201
Pubmed	The ancestral gene for transcribed, low-copy repeats in the Prader-Willi/Angelman region encodes a large protein implicated in protein trafficking, which is deficient in mice with neuromuscular and spermiogenic abnormalities.	HERC2 HERC1	1.14e-04	7	82	2	9949213
Pubmed	MCM9 deficiency delays primordial germ cell proliferation independent of the ATM pathway.	ATM DDX4	1.14e-04	7	82	2	26388201
Pubmed	Functional proteomic analysis of human nucleolus.	RRP9 PWP2 MTREX GNL3	1.19e-04	106	82	4	12429849
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	BLMH ADSS2 HSDL2 AMOT VPS13C RRP9 RAB3GAP2 PWP2 YTHDC2 ATM MTREX GNL3	1.25e-04	1425	82	12	30948266
Pubmed	Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.	ADSS2 ESD PWP2 CBX4 ATM MTREX PFKP EIF2A USP48 GNL3	1.36e-04	1014	82	10	32416067
Pubmed	LONP1-mediated mitochondrial quality control safeguards metabolic shifts in heart development.	PFKP EIF2A ADSS1	1.78e-04	46	82	3	35237793
Pubmed	Global analysis of TDP-43 interacting proteins reveals strong association with RNA splicing and translation machinery.	PWP2 YTHDC2 MTREX EIF4G3 GNL3	1.89e-04	223	82	5	20020773
Pubmed	RNA binding protein RBM46 regulates mitotic-to-meiotic transition in spermatogenesis.	YTHDC2 DDX4	1.96e-04	9	82	2	36001654
Pubmed	Hypersensitivity of primordial germ cells to compromised replication-associated DNA repair involves ATM-p53-p21 signaling.	ATM DDX4	1.96e-04	9	82	2	25010009
Pubmed	The conditional deletion of steroidogenic factor 1 (Nr5a1) in Sox9-Cre mice compromises testis differentiation.	FST DDX4	1.96e-04	9	82	2	33627800
Pubmed	Duplication and extensive remodeling shaped POTE family genes encoding proteins containing ankyrin repeat and coiled coil domains.	POTEE POTEM	1.96e-04	9	82	2	16364570
Pubmed	Estrogen-regulated feedback loop limits the efficacy of estrogen receptor-targeted breast cancer therapy.	VRK2 DSPP AMOT RAB3GAP2 LAMA2 GRIA1 NOSTRIN HERC6	2.17e-04	686	82	8	29987050
Pubmed	METTL3 protects METTL14 from STUB1-mediated degradation to maintain m6 A homeostasis.	HMX3 PUM2 HERC1 MTREX GNL3	2.23e-04	231	82	5	36597993
Pubmed	Interactome analyses revealed that the U1 snRNP machinery overlaps extensively with the RNAP II machinery and contains multiple ALS/SMA-causative proteins.	BLMH TGM1 RRP9 MTREX GNL3	2.87e-04	244	82	5	29884807
Pubmed	Follistatin regulates enamel patterning in mouse incisors by asymmetrically inhibiting BMP signaling and ameloblast differentiation.	DSPP FST	2.98e-04	11	82	2	15525533
Pubmed	De novo purine nucleotide biosynthesis.	ADSS2 ADSS1	2.98e-04	11	82	2	1574589
Pubmed	A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.	CEP350 SYTL4 SH3PXD2A AMOT PUM2 YTHDC2 EIF4G3 EIF2A	3.12e-04	724	82	8	36232890
Pubmed	Proteomic analysis and identification of cellular interactors of the giant ubiquitin ligase HERC2.	BLMH HERC2 HERC1 HPS5	3.36e-04	139	82	4	25476789
Pubmed	MicroRNA-300 Regulates the Ubiquitination of PTEN through the CRL4BDCAF13 E3 Ligase in Osteosarcoma Cells.	RRP9 PWP2 GNL3	3.37e-04	57	82	3	29499938
Pubmed	An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.	CEP350 VRK2 SYTL4 VPS13C RAB3GAP2 PUM2 PRRC1 GNL3	3.39e-04	733	82	8	34672954
Pubmed	Mammalian BTBD12 (SLX4) protects against genomic instability during mammalian spermatogenesis.	ATM DDX4	3.57e-04	12	82	2	21655083
Pubmed	Assignment of the gene for cytoplasmic glutamate-oxaloacetate transaminase to mouse chromosome 19 using chinese hamster x mouse somatic cell hybrids.	ESD SOD1	3.57e-04	12	82	2	7444718
Pubmed	Tumor suppressor BAP1 nuclear import is governed by transportin-1.	BLMH AMOT ESD RAB3GAP2 GET3 PFKP EIF4G3 EIF2A GNL3 SOD1	3.69e-04	1149	82	10	35446349
Pubmed	Systematic analysis of human protein complexes identifies chromosome segregation proteins.	CEP350 BLMH TGM1 SYTL4 RRP9 RECQL4 ATM HERC2 PRRC1 GNL3	3.85e-04	1155	82	10	20360068
Pubmed	Defining the membrane proteome of NK cells.	CEP350 DOCK2 HSDL2 LPCAT3 RECQL4 DOCK10 HERC2 PFKP GNL3 KIF2C	4.20e-04	1168	82	10	19946888
Pubmed	Autosomal Recessive Congenital Ichthyosis	TGM1 SULT2B1	4.21e-04	13	82	2	20301593
Pubmed	MCM8 interacts with DDX5 to promote R-loop resolution.	ATM DDX4	4.21e-04	13	82	2	38858601
Pubmed	HIF1 inhibitor acriflavine rescues early-onset preeclampsia phenotype in mice lacking placental prolyl hydroxylase domain protein 2.	AMOT EIF2A	4.21e-04	13	82	2	36227697
Pubmed	Complementation analyses for 45 mutations encompassing the pink-eyed dilution (p) locus of the mouse.	HERC2 HPS5	4.21e-04	13	82	2	8601493
Pubmed	The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.	RRP9 PWP2 YTHDC2 HERC2 MTREX EIF4G3 GNL3 KIF2C	4.27e-04	759	82	8	35915203
Pubmed	Ubiquitin-Activated Interaction Traps (UBAITs) identify E3 ligase binding partners.	WBP2 MTREX PFKP	4.32e-04	62	82	3	26508657
Pubmed	Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.	DOCK2 YTHDC2 ATM MTREX PFKP USP48 KIF2C	4.56e-04	582	82	7	20467437
Pubmed	Cullin 1 (CUL1) Promotes Primary Ciliogenesis through the Induction of Ubiquitin-Proteasome-Dependent Dvl2 Degradation.	DSPP AMOT VPS13C VSX1	4.71e-04	152	82	4	34299191
Pubmed	Ezh2, the histone methyltransferase of PRC2, regulates the balance between self-renewal and differentiation in the cerebral cortex.	NEXMIF PFKP ADSS1	4.74e-04	64	82	3	20798045
Pubmed	Identification of the genes regulated by Wnt-4, a critical signal for commitment of the ovary.	FST DDX4	4.91e-04	14	82	2	25645944
Pubmed	Hormad1 mutation disrupts synaptonemal complex formation, recombination, and chromosome segregation in mammalian meiosis.	ATM DDX4	4.91e-04	14	82	2	21079677
Pubmed	Identification of an evolutionarily conserved superfamily of DOCK180-related proteins with guanine nucleotide exchange activity.	DOCK2 DOCK10	4.91e-04	14	82	2	12432077
Pubmed	TRIP12 ubiquitination of glucocerebrosidase contributes to neurodegeneration in Parkinson's disease.	POTEE POTEM VPS13C	5.43e-04	67	82	3	34644545
Pubmed	Regulation of p53 translation and induction after DNA damage by ribosomal protein L26 and nucleolin.	ATM GNL3	5.65e-04	15	82	2	16213212
Pubmed	The conserved RNA helicase YTHDC2 regulates the transition from proliferation to differentiation in the germline.	YTHDC2 DDX4	5.65e-04	15	82	2	29087293
Pubmed	Network organization of the human autophagy system.	ADSS2 SH3PXD2A AMOT ESD RAB3GAP2 PFKP	5.95e-04	437	82	6	20562859
Pubmed	Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.	AMOT RRP9 PWP2 YTHDC2 HERC2 MTREX	6.17e-04	440	82	6	34244565
Pubmed	Modifier genes in mice and humans.	FIGN HPS5	6.45e-04	16	82	2	11256068
Pubmed	SKP2- and OTUD1-regulated non-proteolytic ubiquitination of YAP promotes YAP nuclear localization and activity.	AMOT OTUD7B	6.45e-04	16	82	2	29891922
Pubmed	ARHGAP24 represses β-catenin transactivation-induced invasiveness in hepatocellular carcinoma mainly by acting as a GTPase-independent scaffold.	TGM1 AMOT DOCK10 MTREX PFKP KIF2C	7.02e-04	451	82	6	36168627
Pubmed	A protein-protein interaction map of the TNF-induced NF-κB signal transduction pathway.	ADSS2 AMOT RRP9 KIF2C OTUD7B	7.55e-04	302	82	5	30561431
Pubmed	A direct functional link between the multi-PDZ domain protein GRIP1 and the Fraser syndrome protein Fras1.	LAMA2 GRIA1	8.20e-04	18	82	2	14730302
Pubmed	Six1 is required for signaling center formation and labial-lingual asymmetry in developing lower incisors.	DSPP FST	8.20e-04	18	82	2	32243674
Pubmed	Cardiomyocyte maturation alters molecular stress response capacities and determines cell survival upon mitochondrial dysfunction.	EIF2A SOD1	8.20e-04	18	82	2	38266827
Pubmed	Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV.	WBP2 SUMF2 LPCAT3 ATM WDFY3 HERC1 PFKP EIF2A PRRC1	8.83e-04	1061	82	9	33845483
Pubmed	Genome-wide association study identifies multiple loci associated with both mammographic density and breast cancer risk.	PRKG1 RGP1	9.15e-04	19	82	2	25342443
Pubmed	Meioc maintains an extended meiotic prophase I in mice.	YTHDC2 DDX4	9.15e-04	19	82	2	28380054
Pubmed	Mouse Gonad Development in the Absence of the Pro-Ovary Factor WNT4 and the Pro-Testis Factor SOX9.	FST DDX4	9.15e-04	19	82	2	32365547
Pubmed	Catalog of 680 variations among eight cytochrome p450 ( CYP) genes, nine esterase genes, and two other genes in the Japanese population.	TGM1 ESD	9.15e-04	19	82	2	12721789
Pubmed	Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain.	DOCK2 PUM2 RGP1	1.01e-03	83	82	3	9039502
Pubmed	RUNX1 maintains the identity of the fetal ovary through an interplay with FOXL2.	FST DDX4	1.12e-03	21	82	2	31712577
Pubmed	Genetic mapping in mammals: chromosome map of domestic cat.	ESD SOD1	1.12e-03	21	82	2	7063884
Pubmed	NMRK2 Gene Is Upregulated in Dilated Cardiomyopathy and Required for Cardiac Function and NAD Levels during Aging.	LAMA2 SOD1	1.12e-03	21	82	2	33805532
Pubmed	Inactivation of Wt1 causes pre-granulosa cell to steroidogenic cell transformation and defect of ovary development†.	FST DDX4	1.12e-03	21	82	2	32301970
Pubmed	A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene.	HSDL2 RRP9 SYPL2 RGP1 KIF2C	1.14e-03	331	82	5	19490893
Cytoband	14q11.2	IRF9 TGM1 POTEM POTEG	3.15e-04	180	82	4	14q11.2
Cytoband	Ensembl 112 genes in cytogenetic band chr5q11	MTREX FST DDX4	6.75e-04	95	82	3	chr5q11
Cytoband	1p36.12	EIF4G3 USP48	2.24e-03	39	82	2	1p36.12
GeneFamily	Ankyrin repeat domain containing\|POTE ankyrin domain containing	POTEE POTEM POTEG	4.05e-06	13	45	3	685
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ABI3BP AMOT PALM3 WDFY3 NOSTRIN FIGN	1.59e-06	194	82	6	8ddcaaf24cee6e30d5be52c0cbf778cfba309c53
ToppCell	Thalamus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)\|Thalamus / BrainAtlas - Mouse McCarroll V32	HIPK4 PCDHGA9 KCNH1 CRHBP DDX4	8.01e-06	148	82	5	afebb64365c94b9476494bffe7c364677f19c8cf
ToppCell	Thalamus-Neuronal-Inhibitory\|Thalamus / BrainAtlas - Mouse McCarroll V32	HIPK4 PCDHGA9 KCNH1 CRHBP DDX4	8.01e-06	148	82	5	5f82e5ecacfd223020b8ee975c17d68c1fe6db38
Disease	sarcoma (biomarker_via_orthology)	ADSS2 ADSS1	2.07e-05	3	78	2	DOID:1115 (biomarker_via_orthology)
Disease	attention deficit hyperactivity disorder, substance abuse, antisocial behaviour measurement	VRK2 RAB3GAP2 PLCL2 DOCK10 LAMA2 PRKG1 HERC1 FIGN HPS5	2.62e-04	801	78	9	EFO_0003888, EFO_0007052, MONDO_0002491
Disease	Congenital Nonbullous Ichthyosiform Erythroderma	TGM1 SULT2B1	3.74e-04	11	78	2	C0079154
Disease	non-dense area measurement, mammographic density measurement	PRKG1 RGP1	7.08e-04	15	78	2	EFO_0005941, EFO_0006504
Disease	advanced glycosylation end product-specific receptor ligand measurement	DSPP B4GALNT3	1.40e-03	21	78	2	EFO_0010762
Disease	sudden cardiac arrest	FMO4 GRIA1 YTHDC2	1.40e-03	83	78	3	EFO_0004278
Disease	alanine measurement	KCNH1 SLC38A4 RECQL4	1.55e-03	86	78	3	EFO_0009765
Disease	osteoarthritis, hip	PLCL2 HERC2 GNL3	1.88e-03	92	78	3	EFO_1000786
Disease	Neurodevelopmental Disorders	KCNH1 NEXMIF WDFY3	1.94e-03	93	78	3	C1535926
Disease	white matter integrity, age at assessment	SH3PXD2A FIGN	2.15e-03	26	78	2	EFO_0004641, EFO_0008007
Disease	Lewy body dementia, Lewy body dementia measurement	HMX3 HPS5	2.15e-03	26	78	2	EFO_0006792, EFO_0006799
Disease	hearing impairment	TMC1 DSPP SOD1	2.26e-03	98	78	3	C1384666
Disease	status epilepticus (biomarker_via_orthology)	GRIA1 ATM QDPR	2.39e-03	100	78	3	DOID:1824 (biomarker_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
KGEDESWDFGTGAGF	ESD	91	P10768
DDKSWKGSLGILLGG	AMOT	816	Q4VCS5
GSGKNSWKSEAEGGE	DDX4	221	Q9NQI0
VGKTGKEWTAPGEFG	B4GALNT3	211	Q6L9W6
HKGEGNGSKWAEVGG	DSPP	76	Q9NZW4
VAGGWAGGNAKSKSL	QDPR	86	P09417
KLVKENGAGEFWAGS	OTOR	71	Q9NRC9
TKDGQKGIFLGDDEW	PUM2	31	Q8TB72
GAKTGGGEETWEAEK	PALM3	381	A6NDB9
LKSWKGGKEEAAGDG	OTUD7B	556	Q6GQQ9
LEGGKGGIADSVAKW	RAB3GAP2	931	Q9H2M9
LDAFGEGKGKTAWVG	SLC16A9	41	Q7RTY1
EGKGKTAWVGSLASG	SLC16A9	46	Q7RTY1
AGSGLVAKWLGEAEK	FIGN	551	Q5HY92
VLGKGTFGEVAKGWR	HIPK4	16	Q8NE63
GKVFSWGEGDDGKLG	HERC2	3066	O95714
EGLVFSWGDGDFGKL	HERC2	3171	O95714
GAAAATPGAEDWKKG	HMX3	201	A6NHT5
KGDWFGEKALQGEDV	PRKG1	286	Q13976
GFKIALDDEGTAGGW	MGAM	2631	O43451
AWKVKLVGEGADDAG	HERC1	4511	Q15751
SSGGGLHLIQKEGWK	HPS5	51	Q9UPZ3
AEDGGGLKGWTKVLI	PCDHGA9	321	Q9Y5G4
DGFAKGQIKEIGWTD	PFKP	451	Q01813
DIGGLWKFTESSKDG	FMO4	36	P31512
SWGKNSHGQLGLGKE	HERC6	151	Q8IVU3
AILGKGDVFGDVFWK	KCNH1	636	O95259
GFNGFEEKGKAKWDA	LPCAT3	301	Q6P1A2
DGGTWFLDLKSKGGN	HSDL2	341	Q6YN16
KGKVSFLWDVGSGVG	LAMA2	2201	P24043
TGGKKCLWDFKVGRG	FST	251	P19883
GSGKSKVGAWGDYDD	POTEE	111	Q6S8J3
KDIKSGLGGAWAFVL	ATM	1451	Q13315
GKHGGSDIKWVDGGK	DOCK10	826	Q96BY6
KVIASKGDSGGQGLW	DOCK2	366	Q92608
GGDFLKVFDGWILKG	CRHBP	106	P24387
GKGTEETFWLIGKKG	GUCY2F	1051	P51841
DKWAQGAGAKGYLGA	CBX4	196	O00257
KGETSFAKGFWAGVE	CEP350	2516	Q5VT06
IKDGEAVWFGCDVGK	BLMH	316	Q13867
SLKWIFVGGKGGVGK	GET3	36	O43681
KGKYKEGDTGGPAVW	IRF9	66	Q00978
GKEGLWKLLGGFQET	GNL3	236	Q9BVP2
KDGTLFAWGNGEKVN	EIF2A	46	Q9BY44
WYDKGECGSGGGDSK	GRIA1	781	P42261
EAATKALGGEGWEKL	FLAD1	206	Q8NFF5
QLGSWGKGSSGGAKA	EIF4G3	1071	O43432
VSVEWAEGGATKGKE	KIF2C	41	Q99661
KEGGWWFGSLNGKKG	NOSTRIN	471	Q8IVI9
SGSKTDAGKIDGGWR	RUSC1	286	Q9BVN2
KGGEGGELQVWIKEA	SYTL4	521	Q96C24
VAAAAWGKGLTDVKG	SYPL2	166	Q5VXT5
WQGKFPKGDKAEDGF	SUMF2	196	Q8NBJ7
FVEFGAGKGKLSHWV	TRMT13	186	Q9NUP7
VLGAQWGDEGKGKVV	ADSS1	36	Q8N142
WGDEGKGKVVDLLAT	ADSS1	41	Q8N142
KGEVQFGSWFDHIKG	SULT2B1	181	O00204
EGGKKDSWLAELAGE	RGP1	186	Q92546
QKWRKKGECFGGGGA	RECQL4	381	O94761
QKGLSGDWALGKESS	NEXMIF	1276	Q5QGS0
QAKKAGRGLFGGWSE	PNMA8B	426	Q9ULN7
SKEGQEKGWLSIDGF	PLCL2	391	Q9UPR0
DEASAGGIWGFIKGV	PRRC1	206	Q96M27
TVVLGAQWGDEGKGK	ADSS2	31	P30520
LGEKAFGWPGKIGAF	SLC38A4	141	Q969I6
KVWGSIKGLTEGLHG	SOD1	31	P00441
EGALGKGKGKRWFAF	TMC1	131	Q8TDI8
GDKKGGFSIFWADDG	ALDH1L1	126	O75891
DKLAGLWGSDHFKEG	VSX1	286	Q9NZR4
GQKWKELGDSLTFGS	ZNF197	341	O14709
LIKFKEGLSGGGWLE	WDFY3	1701	Q8IZQ1
KVKNEGDDFGWGVVV	MTREX	661	P42285
GDDFGWGVVVNFSKK	MTREX	666	P42285
GADDGSVALWGLSKK	RRP9	341	O43818
GGDDGKVKVWNTLSG	PWP2	391	Q15269
GGQKAEVIDKNSGGW	SH3PXD2A	471	Q5TCZ1
AGKGDSLASWDGILD	TBC1D23	61	Q9NUY8
TGEKRGGWFSGLWGK	VPS13C	466	Q709C8
KSQDWGSAGLGGVFK	YTHDC2	1356	Q9H6S0
GKGGSGGWKAQVVKA	TGM1	186	P22735
EFGVKDNVEGGIWSK	ABI3BP	191	Q7Z7G0
LLKAAVKGSDGFWVG	USP48	581	Q86UV5
GSGKSKVGPWGDYDD	POTEG	111	Q6S5H5
GSGKSKVGPWGDYDD	POTEM	111	A6NI47
GNQWVLGKKIGSGGF	VRK2	26	Q86Y07
YIKGTVKAEAGGGWE	WBP2	91	Q969T9