Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionubiquitin-like protein ligase activity

FBXO40 TRIM73 TRIM71 PCGF3 TRIM24 UBOX5 EGR2 TRIM28 ZMIZ2 RNF146 NEURL1 TRIM8 HLTF TRIM50 HERC2 RNF145 RNF122 TRIM74

6.28e-1239811018GO:0061659
GeneOntologyMolecularFunctionaminoacyltransferase activity

FBXO40 QPCTL TRIM73 TRIM71 PCGF3 TRIM24 UBOX5 EGR2 TRIM28 ZMIZ2 RNF146 NEURL1 TRIM8 HLTF TRIM50 HERC2 TRIM36 RNF145 RNF122 TRIM74

1.08e-1153211020GO:0016755
GeneOntologyMolecularFunctionacyltransferase activity

FBXO40 QPCTL TRIM73 ZDHHC16 PORCN TRIM71 PCGF3 ELP3 TRIM24 UBOX5 EGR2 TRIM28 ZMIZ2 RNF146 NEURL1 TRIM8 HLTF TRIM50 HERC2 TRIM36 RNF145 RNF122 TRIM74

3.05e-1177511023GO:0016746
GeneOntologyMolecularFunctionubiquitin-like protein transferase activity

FBXO40 TRIM73 TRIM71 PCGF3 TRIM24 UBOX5 EGR2 TRIM28 ZMIZ2 RNF146 NEURL1 TRIM8 HLTF TRIM50 HERC2 TRIM36 RNF145 RNF122 TRIM74

4.71e-1151211019GO:0019787
GeneOntologyMolecularFunctionubiquitin protein ligase activity

FBXO40 TRIM73 TRIM71 PCGF3 TRIM24 UBOX5 TRIM28 RNF146 NEURL1 TRIM8 HLTF TRIM50 HERC2 RNF145 RNF122 TRIM74

2.17e-1037211016GO:0061630
GeneOntologyMolecularFunctionubiquitin-protein transferase activity

FBXO40 TRIM73 TRIM71 PCGF3 TRIM24 UBOX5 TRIM28 RNF146 NEURL1 TRIM8 HLTF TRIM50 HERC2 TRIM36 RNF145 RNF122 TRIM74

8.91e-1047311017GO:0004842
GeneOntologyMolecularFunctionzinc ion binding

FBXO40 QPCTL TRIM73 TRPS1 TRIM71 TRIM24 TRIM66 TRIM28 ZMIZ2 RNF146 TRIM8 HLTF NFXL1 TRIM50 HERC2 TRIM36 RNF145 TRIM74

1.72e-0689111018GO:0008270
GeneOntologyMolecularFunctiontransition metal ion binding

FBXO40 QPCTL TRIM73 TRPS1 AOX1 TRIM71 TRIM24 TRIM66 TRIM28 ZMIZ2 RNF146 TRIM8 HLTF NFXL1 TRIM50 HERC2 TRIM36 RNF145 TRIM74

2.49e-05118911019GO:0046914
GeneOntologyMolecularFunctionintracellular sodium-activated potassium channel activity

KCNT2 KCNT1

3.01e-0521102GO:0005228
GeneOntologyMolecularFunctioninterleukin-1 receptor activity

IL18RAP IL1RL2

8.24e-0481102GO:0004908
GeneOntologyMolecularFunctionSUMO transferase activity

EGR2 TRIM28 ZMIZ2

1.02e-03361103GO:0019789
GeneOntologyMolecularFunctionhydrolase activity, hydrolyzing N-glycosyl compounds

NTHL1 IL18RAP IL1RL2

1.49e-03411103GO:0016799
GeneOntologyBiologicalProcessprotein modification by small protein conjugation

TRIM73 TRIM71 DCAF16 ZC4H2 TRIM24 UBOX5 FBH1 EGR2 TRIM28 ZMIZ2 RNF146 NEURL1 TRIM8 HLTF UNKL TRIM50 HERC2 RNF122 TRIM74 SMAD7

4.05e-0889310920GO:0032446
GeneOntologyBiologicalProcessprotein modification by small protein conjugation or removal

TRIM73 TRIM71 DCAF16 ZC4H2 TRIM24 UBOX5 FBH1 EGR2 TRIM28 ZMIZ2 RNF146 NEURL1 TRIM8 HLTF UNKL TRIM50 HERC2 RNF122 TRIM74 SMAD7

2.92e-07100910920GO:0070647
GeneOntologyBiologicalProcesspost-translational protein modification

TRIM73 TRIM71 DCAF16 ZC4H2 TRIM24 UBOX5 FBH1 EGR2 TRIM28 ZMIZ2 RNF146 NEURL1 TRIM8 HLTF UNKL TRIM50 HERC2 RNF122 TRIM74 SMAD7

7.79e-07107410920GO:0043687
GeneOntologyBiologicalProcessprotein ubiquitination

TRIM73 TRIM71 DCAF16 ZC4H2 TRIM24 UBOX5 FBH1 RNF146 NEURL1 TRIM8 HLTF UNKL TRIM50 HERC2 RNF122 TRIM74 SMAD7

1.19e-0681110917GO:0016567
MousePhenohypochlorhydria

TRIM73 TRIM50 TRIM74

6.94e-067833MP:0008001
DomainZF_RING_1

TRIM73 TRIM71 PCGF3 TRIM24 UBOX5 TRIM28 RNF146 NEURL1 TRIM8 HLTF NFXL1 UNKL TRIM50 TRIM36 RNF145 RNF122 TRIM74

7.76e-1329110717PS00518
DomainZF_RING_2

TRIM73 TRIM71 PCGF3 TRIM24 UBOX5 TRIM28 RNF146 NEURL1 TRIM8 HLTF NFXL1 UNKL TRIM50 TRIM36 RNF145 RNF122 TRIM74

1.14e-1229810717PS50089
DomainZnf_RING

TRIM73 TRIM71 PCGF3 TRIM24 UBOX5 TRIM28 RNF146 NEURL1 TRIM8 HLTF NFXL1 UNKL TRIM50 TRIM36 RNF145 RNF122 TRIM74

4.80e-1232610717IPR001841
DomainRING

TRIM73 TRIM71 PCGF3 TRIM24 UBOX5 TRIM28 RNF146 NEURL1 TRIM8 HLTF UNKL TRIM50 TRIM36 RNF145 RNF122 TRIM74

1.97e-1130510716SM00184
Domain-

TRIM73 TRIM71 PCGF3 TRIM24 UBOX5 TRIM66 ZNF341 TRIM28 ZMIZ2 RNF146 NEURL1 TRIM8 HLTF TRIM50 TRIM36 RNF145 RNF122 TRIM74

8.33e-11449107183.30.40.10
DomainZnf_RING/FYVE/PHD

TRIM73 TRIM71 PCGF3 TRIM24 UBOX5 TRIM66 ZNF341 TRIM28 ZMIZ2 RNF146 NEURL1 TRIM8 HLTF TRIM50 TRIM36 RNF145 RNF122 TRIM74

1.19e-1045910718IPR013083
Domain-

TRIM73 TRIM71 TRIM24 TRIM66 TRIM28 TRIM8 TRIM50 TRIM36 TRIM74

2.62e-107110794.10.45.10
DomainZF_BBOX

TRIM73 TRIM71 TRIM24 TRIM66 TRIM28 TRIM8 TRIM50 TRIM36 TRIM74

7.81e-10801079PS50119
DomainZnf_B-box

TRIM73 TRIM71 TRIM24 TRIM66 TRIM28 TRIM8 TRIM50 TRIM36 TRIM74

8.74e-10811079IPR000315
DomainZnf_RING_CS

TRIM73 TRIM71 PCGF3 TRIM24 UBOX5 RNF146 TRIM8 HLTF TRIM50 TRIM36 TRIM74

2.40e-0916310711IPR017907
DomainBBOX

TRIM73 TRIM71 TRIM24 TRIM66 TRIM28 TRIM50 TRIM36 TRIM74

5.57e-09691078SM00336
Domainzf-B_box

TRIM73 TRIM71 TRIM24 TRIM66 TRIM28 TRIM50 TRIM36 TRIM74

7.86e-09721078PF00643
Domainzf-C3HC4

TRIM73 PCGF3 TRIM24 TRIM28 RNF146 TRIM8 TRIM50 TRIM36 RNF145 RNF122 TRIM74

6.23e-0822310711PF00097
DomainZnf_C3HC4_RING-type

TRIM73 PCGF3 TRIM8 TRIM50 TRIM36 RNF145 RNF122 TRIM74

6.60e-061721078IPR018957
Domainzf-C2H2

ZNF142 TRPS1 ZBTB47 ZNF236 CHAMP1 ZNF668 ZNF296 ZNF827 EGR2 ZNF341 EGR3 EGR4 ZNF408 GLIS2 FIZ1

9.49e-0669310715PF00096
Domain-

ZNF142 ZBTB47 ZNF236 CHAMP1 ZNF668 ZNF296 ZNF827 EGR2 ZNF341 EGR3 EGR4 ZNF408 GLIS2 FIZ1

3.30e-05679107143.30.160.60
DomainZINC_FINGER_C2H2_2

ZNF142 TRPS1 ZBTB47 ZNF236 CHAMP1 ZNF668 ZNF296 ZNF827 EGR2 ZNF341 EGR3 EGR4 ZNF408 GLIS2 FIZ1

3.50e-0577510715PS50157
DomainZINC_FINGER_C2H2_1

ZNF142 TRPS1 ZBTB47 ZNF236 CHAMP1 ZNF668 ZNF296 ZNF827 EGR2 ZNF341 EGR3 EGR4 ZNF408 GLIS2 FIZ1

3.61e-0577710715PS00028
DomainZnf-RING_LisH

TRIM73 TRIM50 TRIM36 TRIM74

4.14e-05341074IPR027370
Domainzf-RING_UBOX

TRIM73 TRIM50 TRIM36 TRIM74

4.14e-05341074PF13445
DomainZnf_C2H2/integrase_DNA-bd

ZNF142 ZBTB47 ZNF236 CHAMP1 ZNF668 ZNF296 ZNF827 EGR2 ZNF341 EGR3 EGR4 ZNF408 GLIS2 FIZ1

4.18e-0569410714IPR013087
DomainZnf_C2H2-like

ZNF142 TRPS1 ZBTB47 ZNF236 CHAMP1 ZNF668 ZNF296 ZNF827 EGR2 ZNF341 EGR3 EGR4 ZNF408 GLIS2 FIZ1

4.75e-0579610715IPR015880
DomainZnf_C2H2

ZNF142 TRPS1 ZBTB47 ZNF236 CHAMP1 ZNF668 ZNF296 ZNF827 EGR2 ZNF341 EGR3 EGR4 ZNF408 GLIS2 FIZ1

5.40e-0580510715IPR007087
DomainZnF_C2H2

ZNF142 TRPS1 ZBTB47 ZNF236 CHAMP1 ZNF668 ZNF296 ZNF827 EGR2 ZNF341 EGR3 EGR4 ZNF408 GLIS2 FIZ1

5.63e-0580810715SM00355
DomainTIL_dom

MUC5B LRP2 BMPER

6.36e-05141073IPR002919
DomainBbox_C

TRIM24 TRIM66 TRIM28

7.91e-05151073IPR003649
DomainBBC

TRIM24 TRIM66 TRIM28

7.91e-05151073SM00502
DomainDUF3446

EGR2 EGR3

9.72e-0531072IPR021849
DomainDUF3446

EGR2 EGR3

9.72e-0531072PF11928
DomainK_chnl_Ca-activ_BK_asu

KCNT2 KCNT1

1.94e-0441072IPR003929
DomainBK_channel_a

KCNT2 KCNT1

1.94e-0441072PF03493
DomainV5_allergen

CRISPLD2 CRISPLD1

3.22e-0451072IPR002413
DomainLCCL

CRISPLD2 CRISPLD1

4.80e-0461072PS50820
DomainLCCL

CRISPLD2 CRISPLD1

4.80e-0461072SM00603
DomainLCCL

CRISPLD2 CRISPLD1

4.80e-0461072PF03815
DomainLCCL

CRISPLD2 CRISPLD1

4.80e-0461072IPR004043
Domain-

CRISPLD2 CRISPLD1

4.80e-04610722.170.130.20
DomainZinc_finger_PHD-type_CS

TRIM24 TRIM66 TRIM28 NFXL1

5.27e-04651074IPR019786
DomainVWC

MUC5B CHRDL1 BMPER

5.40e-04281073PF00093
DomainVWFC_1

MUC5B CHRDL1 BMPER

1.14e-03361073PS01208
DomainBROMODOMAIN_1

TRIM24 TRIM66 TRIM28

1.23e-03371073PS00633
DomainVWC

MUC5B CHRDL1 BMPER

1.33e-03381073SM00214
DomainVWFC_2

MUC5B CHRDL1 BMPER

1.33e-03381073PS50184
DomainAllrgn_V5/Tpx1_CS

CRISPLD2 CRISPLD1

1.42e-03101072IPR018244
DomainBROMODOMAIN_2

TRIM24 TRIM66 TRIM28

1.66e-03411073PS50014
DomainIL-1_rcpt_fam

IL18RAP IL1RL2

1.73e-03111072IPR015621
DomainCRISP_1

CRISPLD2 CRISPLD1

1.73e-03111072PS01009
DomainCRISP_2

CRISPLD2 CRISPLD1

1.73e-03111072PS01010
DomainBROMO

TRIM24 TRIM66 TRIM28

1.78e-03421073SM00297
DomainBromodomain

TRIM24 TRIM66 TRIM28

1.78e-03421073IPR001487
Domain-

TRIM24 TRIM66 TRIM28

1.78e-034210731.20.920.10
DomainVWF_dom

MUC5B CHRDL1 BMPER

1.78e-03421073IPR001007
DomainTIL

MUC5B BMPER

2.07e-03121072PF01826
DomainC8

MUC5B BMPER

2.07e-03121072PF08742
DomainUnchr_dom_Cys-rich

MUC5B BMPER

2.43e-03131072IPR014853
DomainC8

MUC5B BMPER

2.43e-03131072SM00832
DomainPLAC

ADAMTSL3 ADAMTS16

2.83e-03141072PF08686
Domain-

CRISPLD2 CRISPLD1

3.25e-031510723.40.33.10
DomainCAP

CRISPLD2 CRISPLD1

3.25e-03151072PF00188
DomainCAP_domain

CRISPLD2 CRISPLD1

3.25e-03151072IPR014044
DomainSCP

CRISPLD2 CRISPLD1

3.25e-03151072SM00198
DomainAllrgn_V5/Tpx1

CRISPLD2 CRISPLD1

3.25e-03151072IPR001283
DomainVWD

MUC5B BMPER

3.70e-03161072SM00216
DomainVWF_type-D

MUC5B BMPER

3.70e-03161072IPR001846
DomainVWFD

MUC5B BMPER

3.70e-03161072PS51233
DomainVWD

MUC5B BMPER

3.70e-03161072PF00094
DomainRasGAP_dom

PLXNA3 NF1

4.69e-03181072IPR001936
DomainPLAC

ADAMTSL3 ADAMTS16

5.22e-03191072PS50900
DomainPLAC

ADAMTSL3 ADAMTS16

5.22e-03191072IPR010909
PathwayREACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION

FBXO40 TRIM73 TRIM71 PSMB11 UBOX5 UNKL TRIM50 HERC2 TRIM36 TRIM74

3.89e-062997510MM15711
PathwayREACTOME_CLASS_I_MHC_MEDIATED_ANTIGEN_PROCESSING_PRESENTATION

FBXO40 TRIM73 TRIM71 PSMB11 UBOX5 UNKL TRIM50 HERC2 TRIM36 TRIM74

1.30e-053437510MM15712
Pubmed

Gene structure variation in segmental duplication block C of human chromosome 7q 11.23 during primate evolution.

TRIM73 TRIM50 TRIM74

3.08e-083110326196062
Pubmed

Egr2 and Egr3 in regulatory T cells cooperatively control systemic autoimmunity through Ltbp3-mediated TGF-β3 production.

TGFB3 EGR2 EGR3

3.08e-083110327911796
Pubmed

TRIM50 protein regulates vesicular trafficking for acid secretion in gastric parietal cells.

TRIM73 TRIM50 TRIM74

3.08e-083110322872646
Pubmed

An amphioxus Krox gene: insights into vertebrate hindbrain evolution.

EGR2 EGR3 EGR4

1.23e-074110311180801
Pubmed

Immediate early genes krox-24 and krox-20 are rapidly up-regulated after wounding in the embryonic and adult mouse.

EGR2 EGR3 EGR4

1.23e-074110311891986
Pubmed

Williams-Beuren syndrome TRIM50 encodes an E3 ubiquitin ligase.

TRIM73 TRIM50 TRIM74

3.06e-075110318398435
Pubmed

Induced chromosome deletions cause hypersociability and other features of Williams-Beuren syndrome in mice.

TRIM73 TRIM50 TRIM74

3.06e-075110320049703
Pubmed

TRIM50 regulates Beclin 1 proautophagic activity.

TRIM73 TRIM50 TRIM74

6.11e-076110329604308
Pubmed

No association between EGR gene family polymorphisms and schizophrenia in the Chinese population.

EGR2 EGR3 EGR4

6.11e-076110320144677
Pubmed

TRIM50 promotes NLRP3 inflammasome activation by directly inducing NLRP3 oligomerization.

TRIM73 TRIM50 TRIM74

6.11e-076110336178239
Pubmed

Allele-specific binding of ZFP57 in the epigenetic regulation of imprinted and non-imprinted monoallelic expression.

TRIM73 TRIM50 TRIM74

1.07e-067110326025256
Pubmed

Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.

PLXNA3 TRPS1 ZDHHC16 ZNF236 TRIM24 ZNF668 ZNF296 TRIM28 ZMIZ2 GLIS2 FIZ1 HLTF SMAD7

1.74e-068081101320412781
Pubmed

A comprehensive framework of E2-RING E3 interactions of the human ubiquitin-proteasome system.

TRIM24 TRIM28 RNF146 NEURL1 HLTF RNF122

2.16e-06118110619690564
Pubmed

Analysis of the human E2 ubiquitin conjugating enzyme protein interaction network.

PCGF3 UBOX5 RNF146 TRIM8 TRIM36 TRIM74

8.30e-06149110619549727
Pubmed

TIF1delta, a novel HP1-interacting member of the transcriptional intermediary factor 1 (TIF1) family expressed by elongating spermatids.

TRIM24 TRIM66 TRIM28

8.60e-0613110315322135
Pubmed

EGR1 and EGR2 involvement in vertebrate tendon differentiation.

EGR2 EGR3 EGR4

8.60e-0613110321173153
Pubmed

GWAS of dental caries patterns in the permanent dentition.

ATXN7L1 ZNF827 MYO16 SMAD7

8.76e-0641110423064961
Pubmed

The tripartite motif family identifies cell compartments.

TRIM24 TRIM28 TRIM8 TRIM36

8.76e-0641110411331580
Pubmed

Cell volume changes regulate slick (Slo2.1), but not slack (Slo2.2) K+ channels.

KCNT2 KCNT1

9.91e-062110225347289
Pubmed

Molecular mechanisms of Slo2 K+ channel closure.

KCNT2 KCNT1

9.91e-062110227682982
Pubmed

EGR3 as a potential susceptibility gene for schizophrenia in Korea.

EGR2 EGR3

9.91e-062110220687139
Pubmed

Genetic and functional analyses of early growth response (EGR) family genes in schizophrenia.

EGR2 EGR4

9.91e-062110222691714
Pubmed

Egr-2 and Egr-3 are negative regulators of T cell activation.

EGR2 EGR3

9.91e-062110215834410
Pubmed

Transcription factors early growth response gene (Egr) 2 and 3 control inflammatory responses of tolerant T cells.

EGR2 EGR3

9.91e-062110229314730
Pubmed

A role for dopamine D2 receptors in reversal learning.

DRD2 EGR2

9.91e-062110219401217
Pubmed

NFκB and MAPK signalling pathways mediate TNFα-induced Early Growth Response gene transcription leading to aromatase expression.

EGR2 EGR3

9.91e-062110223485457
Pubmed

Neurofibromas in NF1: Schwann cell origin and role of tumor environment.

NF1 EGR2

9.91e-062110211988578
Pubmed

Nonsyndromic cleft lip and palate: CRISPLD genes and the folate gene pathway connection.

CRISPLD2 CRISPLD1

9.91e-062110221254358
Pubmed

Slack and Slick K(Na) channels regulate the accuracy of timing of auditory neurons.

KCNT2 KCNT1

9.91e-062110217344399
Pubmed

TRIM24 suppresses development of spontaneous hepatic lipid accumulation and hepatocellular carcinoma in mice.

TRIM24 TRIM28

9.91e-062110225281858
Pubmed

Differential distribution of the sodium-activated potassium channels slick and slack in mouse brain.

KCNT2 KCNT1

9.91e-062110226587966
Pubmed

The transcription factors Egr2 and Egr3 are essential for the control of inflammation and antigen-induced proliferation of B and T cells.

EGR2 EGR3

9.91e-062110223021953
Pubmed

Sodium-activated potassium channels shape peripheral auditory function and activity of the primary auditory neurons in mice.

KCNT2 KCNT1

9.91e-062110230796290
Pubmed

Egr2 and 3 control adaptive immune responses by temporally uncoupling expansion from T cell differentiation.

EGR2 EGR3

9.91e-062110228487311
Pubmed

Emerging roles of Egr2 and Egr3 in the control of systemic autoimmunity.

EGR2 EGR3

9.91e-062110227856665
Pubmed

Cardiac Slo2.1 Is Required for Volatile Anesthetic Stimulation of K+ Transport and Anesthetic Preconditioning.

KCNT2 KCNT1

9.91e-062110226845140
Pubmed

Egr2 and 3 control inflammation, but maintain homeostasis, of PD-1high memory phenotype CD4 T cells.

EGR2 EGR3

9.91e-062110232709717
Pubmed

Egr2 and 3 maintain anti-tumour responses of exhausted tumour infiltrating CD8 + T cells.

EGR2 EGR3

9.91e-062110236342511
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

PLXNA3 MYO7A ZNF236 BCR CNPPD1 ZNF296 ZNF827 ZNF341 TRIM28 ZMIZ2 ZNF408 UNKL HERC2 SMAD7

1.06e-0511051101435748872
Pubmed

Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.

ATXN7L1 TRPS1 AOX1 DCAF16 CHAMP1 TRIM24 BCR TRIM66 PASK ZNF827 TRIM28 FIZ1 NEURL1 LRP2

1.19e-0511161101431753913
Pubmed

The E3-ubiquitin ligase TRIM50 interacts with HDAC6 and p62, and promotes the sequestration and clearance of ubiquitinated proteins into the aggresome.

TRIM73 TRIM50 TRIM74

1.67e-0516110322792322
Pubmed

Iduna is a poly(ADP-ribose) (PAR)-dependent E3 ubiquitin ligase that regulates DNA damage.

HNRNPU RNF146 HLTF

2.03e-0517110321825151
Pubmed

Systematic analysis of dimeric E3-RING interactions reveals increased combinatorial complexity in human ubiquitination networks.

PCGF3 TRIM24 UBOX5 TRIM8 TRIM74

2.17e-05105110522493164
Pubmed

Inducible and constitutive transcription factors in the mammalian nervous system: control of gene expression by Jun, Fos and Krox, and CREB/ATF proteins.

EGR2 EGR3 EGR4

2.43e-051811039858769
Pubmed

Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition.

FBXO40 TRIM73 PCGF3 KLHL38 PASK FBH1 TRIM36 TRIM74

2.52e-05372110822939624
Pubmed

Cells of origin in the embryonic nerve roots for NF1-associated plexiform neurofibroma.

NF1 EGR2

2.97e-053110225446898
Pubmed

Early growth response transcriptional regulators are dispensable for macrophage differentiation.

EGR2 EGR3

2.97e-053110217312150
Pubmed

Hetero-oligomerization among the TIF family of RBCC/TRIM domain-containing nuclear cofactors: a potential mechanism for regulating the switch between coactivation and corepression.

TRIM24 TRIM28

2.97e-053110212096914
Pubmed

Knockout of Slo2.2 enhances itch, abolishes KNa current, and increases action potential firing frequency in DRG neurons.

KCNT2 KCNT1

2.97e-053110226559620
Pubmed

Hepatitis B virus X protein induces expression of Fas ligand gene through enhancing transcriptional activity of early growth response factor.

EGR2 EGR3

2.97e-053110215173177
Pubmed

Oligomerization of transcriptional intermediary factor 1 regulators and interaction with ZNF74 nuclear matrix protein revealed by bioluminescence resonance energy transfer in living cells.

TRIM24 TRIM28

2.97e-053110212684500
Pubmed

Transcriptional repression by RING finger protein TIF1 beta that interacts with the KRAB repressor domain of KOX1.

TRIM24 TRIM28

2.97e-05311029016654
Pubmed

Early growth response genes 2 and 3 induced by AP-1 and NF-κB modulate TGF-β1 transcription in NK1.1- CD4+ NKG2D+ T cells.

EGR2 EGR3

2.97e-053110233011290
Pubmed

Uncontrolled CD21low age-associated and B1 B cell accumulation caused by failure of an EGR2/3 tolerance checkpoint.

EGR2 EGR3

2.97e-053110235045301
Pubmed

TRIM28 is a transcriptional activator of the mutant TERT promoter in human bladder cancer.

TRIM24 TRIM28

2.97e-053110234518220
Pubmed

Egr2 and 3 Inhibit T-bet-Mediated IFN-γ Production in T Cells.

EGR2 EGR3

2.97e-053110228455436
Pubmed

Early Growth Response Genes 2 and 3 Regulate the Expression of Bcl6 and Differentiation of T Follicular Helper Cells.

EGR2 EGR3

2.97e-053110225979336
Pubmed

Epidermal-growth-factor-induced proliferation of astrocytes requires Egr transcription factors.

EGR2 EGR3

2.97e-053110219706684
Pubmed

circZNF827 nucleates a transcription inhibitory complex to balance neuronal differentiation.

HNRNPU ZNF827

5.92e-054110233174841
Pubmed

R-Ras subfamily proteins elicit distinct physiologic effects and phosphoproteome alterations in neurofibromin-null MPNST cells.

NF1 ROCK1

5.92e-054110234530870
Pubmed

EGR1, EGR2, and EGR3 activate the expression of their coregulator NAB2 establishing a negative feedback loop in cells of neuroectodermal and epithelial origin.

EGR2 EGR3

5.92e-054110220506119
Pubmed

Mutations in OTOGL, encoding the inner ear protein otogelin-like, cause moderate sensorineural hearing loss.

MYO7A OTOGL

5.92e-054110223122586
Pubmed

Transcription cofactors TRIM24, TRIM28, and TRIM33 associate to form regulatory complexes that suppress murine hepatocellular carcinoma.

TRIM24 TRIM28

5.92e-054110221531907
Pubmed

The putative nuclear receptor mediator TIF1alpha is tightly associated with euchromatin.

TRIM24 TRIM28

5.92e-054110210318760
Pubmed

Integrated analysis of DNA methylation and RNA‑sequencing data in Down syndrome.

EGR2 EGR3

9.85e-055110227667480
Pubmed

Egr2-independent, Klf1-mediated induction of PD-L1 in CD4+ T cells.

EGR2 EGR3

9.85e-055110229728568
Pubmed

Neurofibromatosis-1 heterozygosity impairs CNS neuronal morphology in a cAMP/PKA/ROCK-dependent manner.

NF1 ROCK1

9.85e-055110221903164
Pubmed

Interaction with members of the heterochromatin protein 1 (HP1) family and histone deacetylation are differentially involved in transcriptional silencing by members of the TIF1 family.

TRIM24 TRIM28

9.85e-055110210562550
Pubmed

Trps1 Regulates Development of Craniofacial Skeleton and Is Required for the Initiation of Palatal Shelves Fusion.

TRPS1 TGFB3

9.85e-055110231130868
Pubmed

TIPUH1 encodes a novel KRAB zinc-finger protein highly expressed in human hepatocellular carcinomas.

HNRNPU TRIM28

9.85e-055110216568080
Pubmed

Opposing regulation of T cell function by Egr-1/NAB2 and Egr-2/Egr-3.

EGR2 EGR3

9.85e-055110218203138
Pubmed

HIV Tat binds Egr proteins and enhances Egr-dependent transactivation of the Fas ligand promoter.

EGR2 EGR3

9.85e-055110211909874
Pubmed

Id3 Restricts γδ NKT Cell Expansion by Controlling Egr2 and c-Myc Activity.

EGR2 EGR3

9.85e-055110230012846
Pubmed

Early growth response proteins (EGR) and nuclear factors of activated T cells (NFAT) form heterodimers and regulate proinflammatory cytokine gene expression.

EGR2 EGR4

9.85e-055110212560487
Pubmed

TIF1gamma, a novel member of the transcriptional intermediary factor 1 family.

TRIM24 TRIM28

9.85e-055110210022127
Pubmed

The gene encoding early growth response 2, a target of the transcription factor NFAT, is required for the development and maturation of natural killer T cells.

EGR2 EGR3

9.85e-055110219169262
Pubmed

Altered expression and coregulation of dopamine signalling genes in schizophrenia and bipolar disorder.

DRD2 MLLT3

9.85e-055110220874815
Pubmed

Structural basis of lysine-acetylated HIV-1 Tat recognition by PCAF bromodomain.

TRIM24 TRIM28

9.85e-055110211931765
Pubmed

Receptor-mediated clustering of FIP200 bypasses the role of LC3 lipidation in autophagy.

MRPS18B LARS1 DHX33 BCR HNRNPU AP4E1 NF1 TRIM28

1.02e-04454110833226137
Pubmed

Nf1 RasGAP inhibition of LIMK2 mediates a new cross-talk between Ras and Rho pathways.

NF1 ROCK1

1.47e-046110223082153
Pubmed

Wnt antagonist gene polymorphisms and renal cancer.

SFRP4 SMAD7

1.47e-046110219562778
Pubmed

Thymocyte apoptosis drives the intrathymic generation of regulatory T cells.

TGFB3 SMAD7

1.47e-046110224474796
Pubmed

Transcription factor EGR2 controls homing and pathogenicity of TH17 cells in the central nervous system.

EGR2 EGR3

1.47e-046110237443284
Pubmed

Egr family members regulate nonlymphoid expression of Fas ligand, TRAIL, and tumor necrosis factor during immune responses.

EGR2 EGR3

1.47e-046110214560009
Pubmed

TGF-β3-expressing CD4+CD25(-)LAG3+ regulatory T cells control humoral immune responses.

TGFB3 EGR2

2.06e-047110225695838
Pubmed

Developmental expression of latent transforming growth factor beta binding protein 2 and its requirement early in mouse development.

TGFB3 MFAP5

2.06e-047110210848613
Pubmed

Regulation of low affinity neurotrophin receptor (p75(NTR)) by early growth response (Egr) transcriptional regulators.

EGR2 EGR3

2.06e-047110217916431
Pubmed

HIV-1 subtypes B and C Tat differentially impact synaptic plasticity expression and implicates HIV-associated neurocognitive disorders.

EGR2 EGR3 EGR4

2.40e-0438110325613138
Pubmed

International Union of Pharmacology. LII. Nomenclature and molecular relationships of calcium-activated potassium channels.

KCNT2 KCNT1

2.74e-048110216382103
Pubmed

Development of the vertebral morphogenetic field in the mouse: interactions between Crossveinless-2 and Twisted Gastrulation.

CHRDL1 BMPER

2.74e-048110218789316
Pubmed

Different classes of coactivators recognize distinct but overlapping binding sites on the estrogen receptor ligand binding domain.

TRIM24 TRIM28

2.74e-04811029774463
Pubmed

Allelic variants of IL1R1 gene associate with severe hand osteoarthritis.

IL18RAP IL1RL2

3.52e-049110220353565
Pubmed

Negative Feedback Loop Mechanism between EAF1/2 and DBC1 in Regulating ELL Stability and Functions.

TRIM28 MLLT3

3.52e-049110236036574
Pubmed

Fine mapping of polymorphic alcohol-related quantitative trait loci candidate genes using interval-specific congenic recombinant mice.

ZNF142 ADRA2B

3.52e-049110212436047
Pubmed

Prdm16 is required for normal palatogenesis in mice.

TGFB3 SMAD7

3.52e-049110220007998
Pubmed

Common genetic variation at the IL1RL1 locus regulates IL-33/ST2 signaling.

IL18RAP IL1RL2

3.52e-049110223999434
Pubmed

TRIM27 negatively regulates NOD2 by ubiquitination and proteasomal degradation.

TRIM8 TRIM50

3.52e-049110222829933
Pubmed

Novel gene function revealed by mouse mutagenesis screens for models of age-related disease.

MYO7A TRIM24 HERC2

3.71e-0444110327534441
Pubmed

Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.

TRPS1 CHAMP1 TRIM24 BCR ZMIZ2 FIZ1 LRP2

3.79e-04418110734709266
Pubmed

A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract.

PLXNA3 TRPS1 PCGF3 CHAMP1 TRIM28 ZMIZ2 RNF146 TRIM8 RNF145

4.31e-04709110922988430
InteractionUBE2D1 interactions

TRIM71 TRIM24 UBOX5 TRIM28 RNF146 NEURL1 TRIM8 TRIM50 HERC2 RNF122

3.78e-0629410710int:UBE2D1
GeneFamilyRing finger proteins

TRIM73 TRIM71 PCGF3 TRIM24 UBOX5 TRIM28 RNF146 NEURL1 TRIM8 HLTF TRIM50 TRIM36 RNF145 RNF122 TRIM74

2.13e-12275841558
GeneFamilyRing finger proteins|Tripartite motif containing|ARF GTPase family

TRIM73 TRIM71 TRIM24 TRIM66 TRIM28 TRIM8 TRIM50 TRIM36 TRIM74

5.52e-109584959
GeneFamilyZinc fingers C2H2-type|ZF class homeoboxes and pseudogenes

ZNF142 TRPS1 ZBTB47 ZNF236 CHAMP1 ZNF668 ZNF296 ZNF827 EGR2 ZNF341 EGR3 EGR4 ZNF408 GLIS2 FIZ1

9.63e-07718841528
GeneFamilyPotassium sodium-activated channel subfamily T

KCNT2 KCNT1

2.13e-052842856
GeneFamilyCD molecules|I-set domain containing|Immunoglobulin like domain containing|Interleukin receptors|TIR domain containing

IL18RAP IL1RL2

2.15e-03158421296
GeneFamilyOlfactory receptors, family 10

OR10H5 OR10H2 OR10H1

3.59e-0366843157
ToppCellBiopsy_IPF-Mesenchymal-PLIN2+_Fibroblasts|Biopsy_IPF / Sample group, Lineage and Cell type

CRISPLD2 SFRP4 AOX1 ADAMTSL3 MFAP5 EGR3 ADAMTS16 CHRDL1

3.68e-0820011082c5626ea8fb4b702d4560117e53edf6cfcf1971e
ToppCellRV-01._Fibroblast_I|RV / Chamber and Cluster_Paper

CRISPLD2 TRPS1 AOX1 ADAMTSL3 MFAP5 KCNT2 BMPER

5.07e-071921107356160b113c3305a61ceeaff33ce3c9da0be2878
ToppCellLV-01._Fibroblast_I|LV / Chamber and Cluster_Paper

CRISPLD2 TRPS1 AOX1 ADAMTSL3 MFAP5 KCNT2 BMPER

5.25e-071931107dc17f3b9758936d428cf17f77a1ce6d4c479b165
ToppCell356C-Fibroblasts-Fibroblast-F|356C / Donor, Lineage, Cell class and subclass (all cells)

SFRP4 AOX1 ADAMTSL3 TGFB3 MFAP5 ADAMTS16 CHRDL1

6.45e-07199110759fe5f3c6338e019a149ab135acf9cc5657298bf
ToppCell(5)_Fibroblast-F|World / Lung cell shreds - cell class (v4) and cell subclass (v4)

CRISPLD2 SFRP4 AOX1 ADAMTSL3 MFAP5 ADAMTS16 CHRDL1

6.45e-0719911071f66db4f502de4a5159cde90fcb3befb26b8d375
ToppCell356C-Fibroblasts-Fibroblast-F-|356C / Donor, Lineage, Cell class and subclass (all cells)

SFRP4 AOX1 ADAMTSL3 TGFB3 MFAP5 ADAMTS16 CHRDL1

6.45e-071991107136f24597ddca5cf2175120975c94782a3232ec6
ToppCellcellseq2-Mesenchymal-Fibroblastic-Fibroblastic_1-AF2|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

CRISPLD2 SFRP4 AOX1 ADAMTSL3 MFAP5 EGR3 CHRDL1

6.67e-07200110744317fbf4d1480a37b50ab2777bf1a3e4fc0c05f
ToppCellnormal_Lung-Fibroblasts-COL14A1+_matrix_FBs|normal_Lung / Location, Cell class and cell subclass

CRISPLD2 SFRP4 AOX1 ADAMTSL3 TGFB3 MFAP5 CHRDL1

6.67e-072001107ee3d06865a6300e1279edf6664320b71647f5efb
ToppCellcellseq2-Mesenchymal-Fibroblastic|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

CRISPLD2 SFRP4 AOX1 ADAMTSL3 MFAP5 EGR3 CHRDL1

6.67e-0720011071c10597edd532bf172ca09870a937d35e2585081
ToppCellcellseq2-Mesenchymal-Fibroblastic-Fibroblastic_1|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

CRISPLD2 SFRP4 AOX1 ADAMTSL3 MFAP5 EGR3 CHRDL1

6.67e-072001107440dda48b09c6a8581b7ca634b0d67f1ecacf65e
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d03-09-Myeloid-Macrophage|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)

P2RX1 ZNF296 CSF3R RNF146 CHRDL1 BMPER

2.70e-0615811061635a85fc73c544028418087f36d28957dd4f458
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d03-09-Myeloid-Macrophage-macrophage,_alveolar|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)

P2RX1 ZNF296 CSF3R RNF146 CHRDL1 BMPER

2.70e-06158110680841dadfa53bcde36a3e486408a095f78e772eb
ToppCell3'-Broncho-tracheal-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CRISPLD2 SFRP4 AOX1 MFAP5 KCNT2 CHRDL1

4.41e-061721106e37c0b5b547a7345179ab258dd2141fec7064c17
ToppCellfacs-Lung-3m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l17|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

CRISPLD2 FBXO40 MFAP5 KCNT2 EGR2 KCNT1

5.72e-06180110639ae8586efd91536e9ac6408d26de7e6d6237c41
ToppCellwk_20-22-Mesenchymal-Chondrocyte-intermediate_chondrocyte|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

TRPS1 ADAMTSL3 TRIM24 KCNT2 BMPER CRISPLD1

6.29e-0618311061464b5c4425e8776c4aeb4d2b560481d4bf13931
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

STAB2 MUC5B OTOGL ADAMTS16 LRP2 MYO16

6.49e-0618411062cbed6462fea2622871bb7e49b0df3d984239281
ToppCell3'-Broncho-tracheal-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-Adventitial_fibroblasts_L.2.1.0.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CRISPLD2 SFRP4 ADAMTSL3 MFAP5 MRAP CHRDL1

6.49e-0618411064a9f798c67b9998bffe44242b210cc1e224ff5b1
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

STAB2 MUC5B OTOGL ADAMTS16 LRP2 MYO16

6.49e-061841106ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

STAB2 MUC5B OTOGL ADAMTS16 LRP2 MYO16

6.49e-0618411062b19a8c5f823e00812908b23e66bb4e563278aff
ToppCellTCGA-Breast-Primary_Tumor-Breast_Carcinoma-Infiltrating_Lobular_Carcinoma-6|TCGA-Breast / Sample_Type by Project: Shred V9

CRISPLD2 SFRP4 ZBTB47 TGFB3 EGR3 ACKR1

7.34e-061881106c90669b51e1902fe7726555290c91c92a911df83
ToppCell5'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-Adventitial_fibroblasts_L.2.1.2.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CRISPLD2 SFRP4 AOX1 MFAP5 ADAMTS16 CHRDL1

7.34e-061881106e18065bbc26d6f3774fd1f478fb41d8fb555fa26
ToppCell5'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-Adventitial_fibroblasts_L.2.1.2.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CRISPLD2 SFRP4 AOX1 MFAP5 ADAMTS16 CHRDL1

7.57e-061891106d531399749409d614adca13d181830c6e3287508
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L1-4_LAMP5_DUSP4_(Lamp5_Rosehip)|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

TBL1Y SLC10A4 ADAMTSL3 ANOS1 CHRDL1 MYO16

7.57e-061891106979b7fa947538aa7ca4a219263da2575869a2caa
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

TBL1Y SLC10A4 ADAMTSL3 ANOS1 CHRDL1 MYO16

7.80e-06190110656cc761e50fddfb5366391518b4d8e16589b6b42
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_1|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

TBL1Y SLC10A4 ADAMTSL3 ANOS1 CHRDL1 MYO16

7.80e-06190110625d4b591f75c26e404a34c42f1742d580af6598d
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L1-4_LAMP5_DUSP4_(Lamp5_Rosehip)|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

TBL1Y SLC10A4 ADAMTSL3 ANOS1 CHRDL1 MYO16

7.80e-061901106be2b184a3559da41ba387ae0fdbeb9ae532868a5
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

TBL1Y SLC10A4 ADAMTSL3 ANOS1 CHRDL1 MYO16

8.28e-061921106f6ec683b2133b3095a1fcc06ca8605cf38f774b5
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L1-4_LAMP5_DUSP4_(Lamp5_Rosehip)|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

TBL1Y SLC10A4 ADAMTSL3 ANOS1 CHRDL1 MYO16

8.28e-061921106342842378c20267c5044bdd622515e8b9f895623
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L1-4_LAMP5_DUSP4_(Lamp5_Rosehip)|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

TBL1Y SLC10A4 ADAMTSL3 ANOS1 CHRDL1 MYO16

8.28e-061921106bd3fa6c8fcb618db64d11f25cabaf08608957c35
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_1|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

TBL1Y SLC10A4 ADAMTSL3 ANOS1 CHRDL1 MYO16

8.28e-061921106690b3d17c481159bc96b8bc7f6a66b51343ee858
ToppCellChildren_(3_yrs)-Mesenchymal-matrix_fibroblast_2_cell-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

AOX1 ADAMTSL3 TGFB3 MFAP5 ADAMTS16 CHRDL1

8.28e-061921106e0f4e4470a71bfa81d9dcd8594e5f82aafc24f81
ToppCellMesenchymal-matrix_fibroblast_2_cell|World / Lineage, Cell type, age group and donor

CRISPLD2 AOX1 ADAMTSL3 MFAP5 KCNT2 CHRDL1

8.28e-061921106a769158c49d2b208c4224d85e7ae68c85cc372ed
ToppCell5'-Adult-SmallIntestine-Mesenchymal-fibroblastic-mLN_Stroma_(FMO2+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CRISPLD2 AOX1 KCNT2 CHRDL1 BMPER CRISPLD1

8.53e-0619311067c0d84b92470bfda2db1e5007feee7c1235a0a78
ToppCellTCGA-Colorectal-Primary_Tumor-Colorectal_Adenocarcinoma-Colon_Adenocarcinoma-10|TCGA-Colorectal / Sample_Type by Project: Shred V9

CRISPLD2 TGFB3 EGR2 GLIS2 ADAMTS16 CRISPLD1

8.53e-061931106194e7fa00a50cc4e026987b715323d125d79594e
ToppCellRV-02._Fibroblast_II|RV / Chamber and Cluster_Paper

CRISPLD2 TRPS1 ADAMTSL3 MFAP5 KCNT2 BMPER

8.78e-06194110611c79a8c56ece42713b04b321982e41e239f07a5
ToppCellBronchus_Control_(B.)-Epithelial-TX-AT2-2|Bronchus_Control_(B.) / Sample group, Lineage and Cell type

CRISPLD2 ADRA2B EGR2 EGR3 EGR4 CRISPLD1

8.78e-0619411065bfc26668fa8f109f2ebc0d5fd98ab5bd219e62c
ToppCellIPF-Stromal-Fibroblast|World / Disease state, Lineage and Cell class

CRISPLD2 SFRP4 AOX1 MFAP5 EGR3 CHRDL1

9.04e-0619511069c32756edb54f0c211185d9a98073fe01fd1526a
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L1-4_LAMP5_DUSP4_(Lamp5_Rosehip)|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

TBL1Y SLC10A4 ADAMTSL3 ANOS1 CHRDL1 MYO16

9.04e-06195110698ca9f3aa36211dde1e6f7f3817b9418c95e583e
ToppCellIPF-Stromal-Fibroblast|IPF / Disease state, Lineage and Cell class

CRISPLD2 SFRP4 AOX1 MFAP5 EGR3 CHRDL1

9.31e-061961106f7ae604ba32b322d86d68b2b54892e7c6ab06c49
ToppCell(5)_Fibroblasts-(5)_Fibroblast-F|(5)_Fibroblasts / Lung cell shreds - cell class (v4) and cell subclass (v4)

SFRP4 AOX1 ADAMTSL3 MFAP5 ADAMTS16 CHRDL1

9.58e-061971106fbff2fb7a8142b88c9dc71aa10980f4350b7e081
ToppCellCOPD-Stromal-Fibroblast|World / Disease state, Lineage and Cell class

CRISPLD2 SFRP4 AOX1 ADAMTSL3 MFAP5 CHRDL1

9.86e-0619811062f13c0b3372af53d1bd85f9546f315c878580a71
ToppCelldistal-3-mesenchymal-Adventitial_Fibroblast|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

SFRP4 AOX1 MFAP5 EGR3 ADAMTS16 CHRDL1

1.01e-051991106547a7c30abc730af2670aee00c7a6af60426c9ac
ToppCell5'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CRISPLD2 SFRP4 AOX1 MFAP5 ADAMTS16 CHRDL1

1.01e-0519911064e128c705ad36fd840582848f278770f356fcc8b
ToppCell5'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CRISPLD2 SFRP4 AOX1 MFAP5 ADAMTS16 CHRDL1

1.01e-0519911064032f03a4165f5f2a90ef1d8315cc743ce9075bb
ToppCellnucseq-Mesenchymal-Fibroblastic-Fibroblastic_1-AF2|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

CRISPLD2 SFRP4 AOX1 ADAMTSL3 MFAP5 CHRDL1

1.01e-051991106993fa050a095017135a6e723c77cd38b9d782e58
ToppCellBiopsy_Control_(H.)-Mesenchymal-Fibroblasts|Biopsy_Control_(H.) / Sample group, Lineage and Cell type

CRISPLD2 SFRP4 AOX1 MFAP5 ADAMTS16 CHRDL1

1.04e-0520011068d75ce89393df452defacf2ec9a5bd4b7708afbb
ToppCellLung_Parenchyma-Severe-Mesenchymal-Mesenchymal-Fibroblasts-2,_SCARA5-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

CRISPLD2 SFRP4 AOX1 TGFB3 MFAP5 CHRDL1

1.04e-0520011060b2614b8513693dd508c9003699049efd9abac52
ToppCellcellseq-Mesenchymal-Fibroblastic-Fibroblastic_1-AF2|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

CRISPLD2 SFRP4 AOX1 MFAP5 ADAMTS16 CHRDL1

1.04e-05200110628e5354008adf97b17333f17f8cbef930db6729a
ToppCellBronchial-NucSeq-Stromal-Fibroblastic-Fibro_adventitial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

CRISPLD2 AOX1 ADAMTSL3 MFAP5 KCNT2 CHRDL1

1.04e-052001106ad3fdcef895400f929f2ae12ff9bd85fd46adb3a
ToppCellNeuronal-Inhibitory-iA-iA_2(LAMP5)-LCP2--L1-4|Neuronal / cells hierarchy compared to all cells using T-Statistic

TBL1Y SLC10A4 ADAMTSL3 ANOS1 CHRDL1 MYO16

1.04e-052001106f268cb1bb047e88913a828614b0a77871f5f8814
ToppCellBronchial-10x5prime-Stromal|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

CRISPLD2 SFRP4 AOX1 ADAMTSL3 MFAP5 CHRDL1

1.04e-0520011065ea12e17f50fefbf5534e487af3392b2fa2d13ad
ToppCell5'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-Adventitial_fibroblasts_L.2.1.0.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CRISPLD2 SFRP4 AOX1 MFAP5 ADAMTS16 CHRDL1

1.04e-0520011063e6730c9ed7003a4acf501f699a4965a7a50f946
ToppCellNeuronal-Inhibitory-iA-iA_2(LAMP5)-LCP2|Neuronal / cells hierarchy compared to all cells using T-Statistic

TBL1Y SLC10A4 ADAMTSL3 ANOS1 CHRDL1 MYO16

1.04e-0520011065ff9ac97ef970b3b74ebb07f62a0a1f4176a10b4
ToppCelldistal-mesenchymal-Adventitial_Fibroblast-1|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

CRISPLD2 SFRP4 AOX1 MFAP5 ADAMTS16 CHRDL1

1.04e-05200110656e838787385dd282caadeac24fbb0a706bf7f2b
ToppCell3'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-Adventitial_fibroblasts_L.2.1.0.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CRISPLD2 SFRP4 AOX1 MFAP5 ADAMTS16 CHRDL1

1.04e-05200110614f3fe19b6647b32a5e28d717235741997d8522c
ToppCellControl_saline-Mesenchymal_myocytic|Control_saline / Treatment groups by lineage, cell group, cell type

CRISPLD2 SFRP4 ADAMTSL3 TGFB3 KCNT2 CHRDL1

1.04e-0520011065ed4261157cd51109b314818133ac3a0d34ee5fa
ToppCelldistal-1-mesenchymal-Adventitial_Fibroblast|1 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

CRISPLD2 SFRP4 AOX1 ADAMTSL3 MFAP5 CHRDL1

1.04e-052001106738060ed65fa5473fdb39e686f7cdecc059ed92c
ToppCellLPS_IL1RA_TNF-Mesenchymal_myocytic-Myofibroblastic-MatrixFB_->_Myofibroblast|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

CRISPLD2 SFRP4 ADAMTSL3 CHRDL1 MLLT3 CRISPLD1

1.04e-05200110609537dc25f8b8b4654a7c183827ee1522a41a4e0
ToppCellLung_Parenchyma-Severe-Mesenchymal-Mesenchymal-Fibroblasts-2,_SCARA5|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

CRISPLD2 SFRP4 AOX1 TGFB3 MFAP5 CHRDL1

1.04e-0520011068d2ceb2080c67b20f452eeca605aa27a58033c04
ToppCell356C-Fibroblasts|356C / Donor, Lineage, Cell class and subclass (all cells)

CRISPLD2 SFRP4 AOX1 TGFB3 MFAP5 CHRDL1

1.04e-0520011069c95329f0b26ff378de803030d4c28517b3adc85
ToppCellBiopsy_IPF-Mesenchymal-Fibroblasts|Biopsy_IPF / Sample group, Lineage and Cell type

CRISPLD2 SFRP4 AOX1 ADAMTSL3 MFAP5 CHRDL1

1.04e-052001106d8637f1e62d3fb9476dc51e1b1dc2f4b14b5fcd8
ToppCellBronchial-10x5prime-Stromal-Fibroblastic-Fibro_adventitial|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

CRISPLD2 SFRP4 AOX1 ADAMTSL3 MFAP5 CHRDL1

1.04e-052001106b04831708fa20471a127b87e8db3728b6e729ce8
ToppCellNeuronal-Inhibitory-iA-iA_2(LAMP5)-LCP2-|Neuronal / cells hierarchy compared to all cells using T-Statistic

TBL1Y SLC10A4 ADAMTSL3 ANOS1 CHRDL1 MYO16

1.04e-0520011067345cc7dc24b9174541a3e68ecac8c4c092be400
ToppCellBiopsy_IPF-Mesenchymal|Biopsy_IPF / Sample group, Lineage and Cell type

CRISPLD2 SFRP4 AOX1 MFAP5 ADAMTS16 CHRDL1

1.04e-052001106bb605b373caf3f873dc1b87d712704568e0d6040
ToppCellBiopsy_IPF-Mesenchymal-HAS1_High_Fibroblasts|Biopsy_IPF / Sample group, Lineage and Cell type

CRISPLD2 SFRP4 MFAP5 EGR3 ADAMTS16 CHRDL1

1.04e-052001106d02e256b5d65a5c982ba5696bc7e077281ca3e24
ToppCellParenchyma_COVID-19-Stromal-TX-Fibroblasts-2,_SCARA5|Parenchyma_COVID-19 / Sample group, Lineage and Cell type

CRISPLD2 SFRP4 AOX1 TGFB3 MFAP5 CHRDL1

1.04e-052001106c338a08c1605527ab9aaf62ea151a19e8469dc6d
ToppCellTracheal-NucSeq-Stromal-Fibroblastic-Fibro_adventitial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

CRISPLD2 AOX1 ADAMTSL3 MFAP5 KCNT2 CHRDL1

1.04e-0520011060c25d56292b9e5fefa4521b72635449be1ffd6fe
ToppCellcellseq-Mesenchymal-Fibroblastic-Fibroblastic_1|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

CRISPLD2 SFRP4 AOX1 MFAP5 ADAMTS16 CHRDL1

1.04e-05200110656536236a7012efdb28f85b40e464f3da3e87ce8
ToppCelldistal-mesenchymal-Adventitial_Fibroblast|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

CRISPLD2 SFRP4 AOX1 MFAP5 ADAMTS16 CHRDL1

1.04e-052001106687cfada2d0977e8985e0a73a5804f84f2ca9c52
ToppCellCerebellum-Endothelial-MURAL-M1(Rgs5Acta2)-M1_2|Cerebellum / BrainAtlas - Mouse McCarroll V32

IL1RL2 ADRA2B KCNT2 MRAP TRIM36

2.30e-0513711059324b55eac55e0cc1e8e450a4b5374d12e9587a3
ToppCellCerebellum-Endothelial-MURAL-M1(Rgs5Acta2)-M1_2-MURAL_Mural.Acta2Rgs5.Kcnj8_(Mural.Acta2Rgs5.Kcnj8)|Cerebellum / BrainAtlas - Mouse McCarroll V32

IL1RL2 ADRA2B KCNT2 MRAP TRIM36

2.30e-051371105032f8409d0d179e254c8ff632afbda78852a9889
ToppCellCerebellum-Endothelial-MURAL-M1(Rgs5Acta2)-M1_2-MURAL_Mural.Acta2Rgs5.Kcnj8_(Mural.Acta2Rgs5.Kcnj8)-|Cerebellum / BrainAtlas - Mouse McCarroll V32

IL1RL2 ADRA2B KCNT2 MRAP TRIM36

2.30e-051371105265a4a50e48b13c8b3b0730f818235f71fbd6baa
ToppCellSubstantia_nigra-Endothelial-MURAL-M1(Rgs5Acta2)-M1_3-MURAL_Mural.Rgs5Acta2.Rgs5_(Mural.Rgs5Acta2.Rgs5)-|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

LTB4R2 IL1RL2 KLHL38 OTOGL

2.59e-05691104a157b1582401cebd222343d94086dbea876140c2
ToppCellSubstantia_nigra-Endothelial-MURAL-M1(Rgs5Acta2)-M1_3-MURAL_Mural.Rgs5Acta2.Rgs5_(Mural.Rgs5Acta2.Rgs5)|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

LTB4R2 IL1RL2 KLHL38 OTOGL

2.59e-05691104cdd42abdd072aa438830d837ee857529269a81e0
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d03-09-Myeloid-Macrophage-macrophage,_alveolar-Macro_c2-CCL3L1|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)

RGL1 RNF146 FIZ1 CHRDL1 BMPER

3.13e-0514611051e81ad3d6d5d5ad2f0176d2a9593a954d38fa294
ToppCellTCGA-Thymus-Primary_Tumor-Thymoma-Type_AB-8|TCGA-Thymus / Sample_Type by Project: Shred V9

SFRP4 SLC10A4 ADAMTSL3 KCNT2 CRISPLD1

3.67e-0515111055906562efd36fbcb91f96e0a0d3a8fe999ba1e79
ToppCellHippocampus-Neuronal-Excitatory-eN1(Slc17a7)-eN1_2-Pvrl3-Excitatory_Neuron.Slc17a7.Pvrl3-Fos_(CA3_Principal_cells)|Hippocampus / BrainAtlas - Mouse McCarroll V32

PSMB11 IL18RAP EGR2 CEACAM18

4.64e-05801104b661644806e225f215047e78ae46d7cee6efde4f
ToppCell343B-Fibroblasts-Fibroblast-D-|343B / Donor, Lineage, Cell class and subclass (all cells)

CRISPLD2 IL1RL2 EGR4 ABCB8 ADAMTS16

5.29e-0516311058d2b2119c6b3d5b677da6f377fd85146590e1246
ToppCell343B-Fibroblasts-Fibroblast-D|343B / Donor, Lineage, Cell class and subclass (all cells)

CRISPLD2 IL1RL2 EGR4 ABCB8 ADAMTS16

5.29e-051631105acfb2ece6202479e615d54fd3ecb8b4a571b5a18
ToppCell367C-Fibroblasts-Fibroblast-F|367C / Donor, Lineage, Cell class and subclass (all cells)

SFRP4 AOX1 ADAMTSL3 MFAP5 ADAMTS16

5.76e-0516611052887f4f0c218cbcbcc82eef27aa4ee714b35cddb
ToppCell367C-Fibroblasts-Fibroblast-F-|367C / Donor, Lineage, Cell class and subclass (all cells)

SFRP4 AOX1 ADAMTSL3 MFAP5 ADAMTS16

5.76e-0516611051cc291a04f4144abba4aca7badeb7776db05d903
ToppCellChildren_(3_yrs)-Mesenchymal-myofibroblast_cell-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

CRISPLD2 AOX1 KCNT2 OTOGL BMPER

5.76e-05166110594636dbc039f794c735960c3425e00bdd5523602
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-Adaptive_/_Maladaptive_/_Repairing_Fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CRISPLD2 AOX1 ADAMTSL3 KCNT2 KCNT1

6.10e-0516811054b2d29a7843bf45922038c093ca7ec0600756adc
ToppCellfacs-Mammary_Gland-Mammary_Gland-21m-Mesenchymal|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SFRP4 MFAP5 ADAMTS16 CHRDL1 ACKR1

6.27e-051691105bb43abad2c049b7f4d307737347290e01b3339a3
ToppCellfacs-Mammary_Gland-Mammary_Gland-21m-Mesenchymal-stromal_cell|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SFRP4 MFAP5 ADAMTS16 CHRDL1 ACKR1

6.27e-0516911055f18e3f40a5b1b167903f37516ec8181e889c7c5
ToppCelldroplet-Limb_Muscle-MUSCLE-1m-Myeloid-unknown|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ZNF236 P2RX1 CSF3R MRAP CLEC12B

6.27e-051691105bca5322880c09b78ef10d9dda6420a80c1ba7e62
ToppCellfacs-Mammary_Gland-Mammary_Gland-21m-Mesenchymal-stromal_cell|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SFRP4 MFAP5 ADAMTS16 CHRDL1 ACKR1

6.27e-0516911058bfa2d3bb541d02f55d7c95b8fd156c8403befca
ToppCellfacs-Trachea-18m-Mesenchymal-fibroblast-fibroblast_of_trachea-tracheal_fibroblast_l20-1|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SFRP4 AOX1 ZNF668 RNF146 ACKR1

7.20e-0517411051d157f7a919c8246e83d8060d2a0017c6c781ef3
ToppCell343B-Fibroblasts-Fibroblast-A_(Fibroblast_progenitors)-|343B / Donor, Lineage, Cell class and subclass (all cells)

CRISPLD2 SFRP4 AOX1 MFAP5 CHRDL1

7.60e-0517611052e94bbe17c0bb65dc58b4ebc0cb829258bd7373b
ToppCell343B-Fibroblasts-Fibroblast-A_(Fibroblast_progenitors)|343B / Donor, Lineage, Cell class and subclass (all cells)

CRISPLD2 SFRP4 AOX1 MFAP5 CHRDL1

7.60e-051761105f33ab41d121b59d871ad7d48ca021524a027d2ef
ToppCellAT1_cells-Donor_04|World / lung cells shred on cell class, cell subclass, sample id

ANOS1 KCNT2 GLIS2 TRIM50 BMPER

7.81e-0517711053128b8d04687acee1ac4190b2569d6328b98eaf3
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-Adaptive_/_Maladaptive_/_Repairing_Fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

AOX1 ADAMTSL3 MFAP5 KCNT2 BMPER

7.81e-0517711059ec7f1e64312d26d434b3312b58386715dbad644
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

AOX1 ADAMTSL3 MFAP5 KCNT2 BMPER

7.81e-051771105016277dfd59b1793fddaaadc2b3f41622d76ce3a
ToppCellfacs-SCAT|facs / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SFRP4 IL1RL2 CHRDL1 ACKR1 CRISPLD1

8.45e-0518011056c70b6b7480507fa94625013222ad338ee7dd1d9
ToppCell5'-Adult-LymphNode-Mesenchymal-fibroblastic-Transitional_Stromal_3_(C3+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CRISPLD2 ADAMTSL3 TGFB3 EGR3 CHRDL1

8.67e-051811105ab66a89f316b935d9ba1277426d976b1e9e39757
ToppCell3'-Broncho-tracheal-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-Adventitial_fibroblasts_L.2.1.2.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CRISPLD2 SFRP4 AOX1 MFAP5 CHRDL1

8.90e-051821105d179b5deb07c20d49eb6c58d5a65904f8921de3a
ToppCell3'-Distal_airway-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-Adventitial_fibroblasts_L.2.1.0.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CRISPLD2 SFRP4 OTOGL GLIS2 CHRDL1

9.13e-0518311052beb5414958d38a5341870d55229f3b1707e76bf
ToppCell3'-Adult-LargeIntestine-Epithelial-neuro-epithelial-L_cells_(PYY+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PORCN CFAP65 EGR2 EGR3 EGR4

9.13e-05183110549f3ddc1c7c04b4ca837dbd6dad995add82941d6
ToppCellLPS_only-Stromal_mesenchymal-Lung_smooth_muscle-MatrixFB_->_Myofibroblast|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CRISPLD2 SFRP4 ADAMTSL3 CHRDL1 CRISPLD1

9.13e-05183110512daaea821e49bc94a01e2496331e92a80d27339
ToppCelldroplet-Limb_Muscle-Pre-Sort-18m-Mesenchymal|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CRISPLD2 SFRP4 TGFB3 MFAP5 CHRDL1

9.37e-051841105c9d7ec17cc5b7ba1b1e721ca392746e8f4a3d41f
DrugMexiletine hydrochloride [5370-01-4]; Down 200; 18.6uM; PC3; HT_HG-U133A

DRD2 STAB2 QPCTL HNRNPU PASK NF1 ZMIZ2 NEURL1

4.91e-0619710983781_DN
DrugMethyldopate hydrochloride [2508-79-4]; Up 200; 14.6uM; MCF7; HT_HG-U133A

SFRP4 TBL1Y UBOX5 RGL1 NF1 ZMIZ2 UNKL RNF122

5.29e-0619910984986_UP
DrugOrlistat; Down 200; 10uM; PC3; HT_HG-U133A

DRD2 HNRNPU CNPPD1 MFAP5 SPATA2L NF1 ZNF408 EDRF1

5.29e-0619910986420_DN
DiseaseColorectal Carcinoma

SFRP4 NTHL1 ADAMTSL3 NT5C CNPPD1 NF1 TRIM28 NEURL1 LRP2 EDRF1 SMAD7

3.84e-0570210411C0009402
Diseasecolon carcinoma

RGL1 CRISPLD1 SMAD7

1.04e-04261043EFO_1001950
DiseaseChild Development Disorders, Specific

DRD2 LRP2 KCNT1

1.45e-04291043C0085997
DiseaseChild Development Deviations

DRD2 LRP2 KCNT1

1.45e-04291043C0085996
DiseaseDevelopmental Disabilities

DRD2 LRP2 KCNT1

1.61e-04301043C0008073
DiseaseIntellectual Disability

ZNF142 CHAMP1 HNRNPU AP4E1 ADRA2B NF1 TRIM8 LRP2

1.89e-044471048C3714756
Diseasecorneodesmosin measurement

TRPS1 ACKR1

4.36e-0491042EFO_0801499
DiseaseColorectal Neoplasms

SFRP4 NT5C CNPPD1 TRIM28 NEURL1 SMAD7

4.56e-042771046C0009404
Diseaselanguage impairment

LTB4R2 NOP9

6.63e-04111042EFO_0005425
Diseaseserum ST2 measurement

IL18RAP IL1RL2

6.63e-04111042EFO_0005416
Diseaseinterleukin 1 receptor-like 1 measurement

IL18RAP IL1RL2

6.63e-04111042EFO_0008168
Diseasepro‐interleukin‐16 measurement

ADAMTSL3 MLLT3

6.63e-04111042EFO_0010629
Diseasecigarettes per day measurement

DRD2 SWT1 LARS1 SPATA2L ZNF668 ZMIZ2 ZNF408

9.34e-044381047EFO_0006525
Diseaseactinic keratosis

TRPS1 HERC2

1.09e-03141042EFO_0002496
Diseaseinterleukin 18 receptor 1 measurement

IL18RAP IL1RL2

1.25e-03151042EFO_0008178
Diseasenon-word reading

ZMIZ2 ADAMTS16 MLLT3

1.73e-03671043EFO_0005299
Diseaseanorectal malformation

MUC5B LTB4R2

2.02e-03191042MONDO_0019938
DiseaseNonsyndromic Deafness

MYO7A TGFB3 OTOGL

2.97e-03811043C3711374
Diseasealcoholic liver disease

SWT1 AOX1 ZNF827

3.08e-03821043EFO_0008573

Protein segments in the cluster

PeptideGeneStartEntry
AHSIVCRPVQPNFHK

TDRD1

201

Q9BXT4
PHEDLTCCPQRFLHL

CEACAM18

316

A8MTB9
HQTKPQPRTHNCLCT

CAMTA1

251

Q9Y6Y1
PQCHKRHRHCPVVVS

BCR

386

P11274
HPPVNHLRCEKLTFN

MLLT3

111

P42568
HCVATPLLLALFCHQ

ACKR1

296

Q16570
ICPKHCKVPHGLFQF

ADRA2B

396

P18089
ACCTHPLDLLKVHLQ

SLC25A10

21

Q9UBX3
RLSHCSHCVPKLEPI

DCAF16

96

Q9NXF7
KLDCQFSTHHPRPLA

ATXN7L1

451

Q9ULK2
PRMHEACLLQRCHKP

ADAMTS16

1036

Q8TE57
IRHHPANACLIPICS

AOX1

66

Q06278
PSIPCLLHCRVHADV

AP4E1

1096

Q9UPM8
AFSRCHSIINPKPFH

MUC5B

631

Q9HC84
TCPTCRIVIHQSHPL

PCGF3

51

Q3KNV8
ILFTCCHNRHLVLPP

NT5C

161

Q8TCD5
HPPTVHNLCRILAVF

QPCTL

361

Q9NXS2
QLFKKVVPHHCLGCI

RGL1

246

Q9NZL6
IRIHTGHKPFQCRIC

EGR2

361

P11161
LFHLPPNCKRTVCLE

SLC10A4

321

Q96EP9
LRKHQCQSFCEPLFP

ANOS1

96

P23352
QVLHRKLPQFCAHLC

NOP9

286

Q86U38
HFFCHVPPLLKLACG

OR10H5

176

Q8NGA6
HFLCHVPPLLKLACG

OR10H2

176

O60403
NICTSKLHCPAAPEH

PASK

81

Q96RG2
CDLPEPQKSHFCHRN

IL18RAP

46

O95256
LHVLPCLHAFCRPCL

TRIM71

56

Q2Q1W2
HLCPAPCHDQALIKQ

NFXL1

591

Q6ZNB6
LQKCTPHFIHCIRPN

MYO16

1031

Q9Y6X6
PHFIHCIRPNNSKLP

MYO16

1036

Q9Y6X6
SIHQIRPSCAFPVCH

EDRF1

581

Q3B7T1
LLLHHLSELFCPCIP

HERC2

4351

O95714
TLHCAFQPTHPIICF

CFAP65

526

Q6ZU64
NKPDHHFLEAICCFP

KCNT1

821

Q5JUK3
EHRCQLRTHCPAPKT

PLXNA3

811

P51805
FEKPATHCPRIHCPA

CRISPLD2

401

Q9H0B8
GRPLFPHVLCHNCAV

HNRNPU

441

Q00839
PVGDFRCKNHHCIPL

LRP2

3721

P98164
IHTGHKPFQCRICLR

EGR4

506

Q05215
SPTFCHLLHEKVPFC

KCNT2

681

Q6UVM3
IRTHTNEKPHRCPTC

GLIS2

226

Q9BZE0
ACPASCKVIPVHQHL

PSMB11

76

A5LHX3
SVHRPVKQCIHQLCF

MFAP5

96

Q13361
PHFFCDHQPLLRLSC

OR1K1

176

Q8NGR3
VLSKRCPPDCSHQHR

PORCN

376

Q9H237
CHLHFPKSCVLGPIK

IL1RL2

146

Q9HB29
KLQRDSPTCHACLHP

CNPPD1

341

Q9BV87
KVPCARHNLPQLPHF

FBH1

891

Q8NFZ0
EVCPILSCPQHLSHI

BMPER

201

Q8N8U9
SRVRCPNVHCLSPVH

CHRDL1

76

Q9BU40
HVAAHGQSLLKCPRC

CHAMP1

756

Q96JM3
EQLCPFHKPASHCPR

CRISPLD1

401

Q9H336
LRIHTGHKPFQCRIC

EGR3

296

Q06889
AIHPSSVLFHCKPAC

DHX33

651

Q9H6R0
DGQSHCCIPRKHLLL

CSF3R

181

Q99062
PHRCPHISFTGNICV

ELP3

96

Q9H9T3
RLLHGTERPFPCHIC

FIZ1

461

Q96SL8
RHCHIPVEPNTSCLV

FBXO40

21

Q9UH90
LLTRAHVECPPAHTC

CRIPAK

291

Q8N1N5
ITHILNIHCDCNIPP

DRD2

391

P14416
EQPHAKCPLCRNDIH

HLTF

791

Q14527
LDCLHCQRITPKCIH

IZUMO2

146

Q6UXV1
HRPHSAQCIPEKECA

OTOGL

1851

Q3ZCN5
HFACHVPPLLKLACG

OR10H1

176

Q9Y4A9
LSKHPHLCLVALCEA

ABCB8

101

Q9NUT2
TCLFHKTLHPLCPVF

P2RX1

216

P51575
CLPQFRPRIHCNKIS

UBOX5

6

O94941
CKELFTHPLILPCQH

TRIM36

36

Q9NQ86
THPLILPCQHSICHK

TRIM36

41

Q9NQ86
QLHAAHCAALPACRP

SPATA2L

376

Q8IUW3
RVCQLCHPSPVHAAA

LTB4R2

166

Q9NPC1
TLLLAPFCPHLCEHI

LARS1

856

Q9P2J5
LPVHPRCHACLNQAL

NTHL1

291

P78549
LHLCIQKCLPCHREP

MRAP

86

Q8TCY5
LQTCVHPVSLPCKHV

RNF146

41

Q9NTX7
HLSLNTDVCHQPCIP

SWT1

536

Q5T5J6
LIIHTSDHRCNPCPK

CLEC12B

131

Q2HXU8
PKVCVHHRNPLSLFC

TRIM74

86

Q86UV6
IHKCTIKHCPFCPRG

TRPS1

556

Q9UHF7
VGNPCPICRDHKLHV

MRPS18B

101

Q9Y676
RAPKLLPCLHSFCQR

TRIM24

66

O15164
INPELVCCNPHHLSR

SMAD7

186

O15105
TATHNFPCPHCQKVF

ZNF341

561

Q9BYN7
CHQRIHAAQKPYRCP

ZNF668

241

Q96K58
RCHHKQKHCPAVLPS

NEURL1

41

O76050
LGVLPCQHAFHRKCL

RNF122

106

Q9H9V4
CPCLHCHIVKVPILN

TEX37

156

Q96LM6
SSCQCPHILPHQDVL

SFRP4

241

Q6FHJ7
HLCPVCGKALRDPHT

ZNF408

551

Q9H9D4
KQLLPEICHFLHTCR

NF1

111

P21359
DPINPCLRKICHPHA

STAB2

236

Q8WWQ8
IHVCRLGCDHPVKTF

TBL1Y

341

Q9BQ87
EEKQHHPCQKCPRVF

ZBTB47

431

Q9UFB7
CPLFSQHKCAQHRPF

UNKL

36

Q9H9P5
LRPCQHHILCEPCAA

UNKL

651

Q9H9P5
HVFKPPPALECRRCH

ROCK1

1251

Q13464
IYPKPARTHHCSICN

ZDHHC16

161

Q969W1
CCSHLFVLQLVHRPS

ZMIZ2

531

Q8NF64
HTGLKSHQCPLCPFR

ZNF827

396

Q17R98
IRIHTHEKPFKCPQC

ZNF236

501

Q9UL36
PKVCVHHRNPLSLFC

TRIM73

86

Q86UV7
RLKHEGVKPHQCPFC

ZNF142

1191

P52746
LPPNCVLHCHVSTRV

TMUB1

161

Q9BVT8
LHVEKPPAALHCVFC

TRIM8

81

Q9BZR9
DRCPKVFHLSCHVPA

TRIM66

986

O15016
CPLCHCHLKNSSQLP

RNF145

571

Q96MT1
PKVCVHHRNPLSLFC

TRIM50

86

Q86XT4
CHRHSFEAKLTPCPQ

ZMYND15

316

Q9H091
LEISIHCPCHTFQPN

TGFB3

221

P10600
LFCHEPCRPLHQLAT

TRIM28

711

Q13263
ECPHCHVPFGLRATL

ZNF296

446

Q8WUU4
LAVVAQCPHHCPVLG

PRO3102

56

Q9H379
HTLHCVPRRVCVSPL

nan

46

Q6ZSA8
SCHQQIHRNAPICPL

ZC4H2

191

Q9NQZ6
HKSCARTDCPPHLAV

ADAMTSL3

811

P82987
HKLFDHACLTLQCIP

KLHL38

561

Q2WGJ6
LPHVQRFLQSRKHCP

MYO7A

1851

Q13402