Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	inositol 1,4,5-trisphosphate-gated calcium channel activity	ITPR1 ITPR2	8.83e-05	3	109	2	GO:0005220
GeneOntologyBiologicalProcess	cellular response to cAMP	AKAP6 RAPGEF1 ITPR1 ITPR2 AKAP9	8.05e-06	53	107	5	GO:0071320
GeneOntologyBiologicalProcess	cardiocyte differentiation	AKAP6 MYH6 PDGFB BMP2 ARRB2 CBY1 AKAP13 MYO18B	2.01e-05	221	107	8	GO:0035051
GeneOntologyBiologicalProcess	cardiac muscle cell differentiation	AKAP6 MYH6 BMP2 ARRB2 CBY1 AKAP13 MYO18B	3.86e-05	177	107	7	GO:0055007
GeneOntologyBiologicalProcess	cardiac muscle tissue development	AKAP6 HSPG2 MYH6 BMP2 ARRB2 CBY1 NPRL3 AKAP13 MYO18B	5.21e-05	327	107	9	GO:0048738
GeneOntologyBiologicalProcess	striated muscle tissue development	AKAP6 HSPG2 MYH6 BMP2 ARRB2 CBY1 NPRL3 AKAP13 MYO18B	8.57e-05	349	107	9	GO:0014706
GeneOntologyCellularComponent	ciliary basal body	TTLL9 NPHP4 DCTN1 PJA2 AKAP9 CBY1 PCNT	7.81e-05	195	110	7	GO:0036064
GeneOntologyCellularComponent	myosin filament	MYH6 MYH13 MYO18B	3.00e-04	25	110	3	GO:0032982
GeneOntologyCellularComponent	myosin II complex	MYH6 MYH13 MYO18B	4.22e-04	28	110	3	GO:0016460
Domain	PACT_coil_coil	AKAP9 PCNT	3.31e-05	2	108	2	PF10495
Domain	PACT_domain	AKAP9 PCNT	3.31e-05	2	108	2	IPR019528
Domain	IQ	MYH6 MYH13 RASGRF1 CAMTA2 MYO18B	5.66e-05	71	108	5	PF00612
Domain	InsP3_rcpt-bd	ITPR1 ITPR2	9.90e-05	3	108	2	IPR000493
Domain	IQ	MYH6 MYH13 RASGRF1 CAMTA2 MYO18B	1.06e-04	81	108	5	SM00015
Domain	Myosin-like_IQ_dom	MYH6 MYH13 MYO18B	1.70e-04	19	108	3	IPR027401
Domain	-	MYH6 MYH13 MYO18B	1.70e-04	19	108	3	4.10.270.10
Domain	IQ_motif_EF-hand-BS	MYH6 MYH13 RASGRF1 CAMTA2 MYO18B	1.75e-04	90	108	5	IPR000048
Domain	IQ	MYH6 MYH13 RASGRF1 CAMTA2 MYO18B	2.04e-04	93	108	5	PS50096
Domain	RIH_assoc-dom	ITPR1 ITPR2	4.89e-04	6	108	2	IPR013662
Domain	Ins145_P3_rec	ITPR1 ITPR2	4.89e-04	6	108	2	PF08709
Domain	RIH_assoc	ITPR1 ITPR2	4.89e-04	6	108	2	PF08454
Domain	RIH_dom	ITPR1 ITPR2	4.89e-04	6	108	2	IPR000699
Domain	Ins145_P3_rcpt	ITPR1 ITPR2	4.89e-04	6	108	2	IPR014821
Domain	Ryanodine_recept-rel	ITPR1 ITPR2	4.89e-04	6	108	2	IPR015925
Domain	-	ITPR1 ITPR2	4.89e-04	6	108	2	1.25.10.30
Domain	RYDR_ITPR	ITPR1 ITPR2	4.89e-04	6	108	2	PF01365
Domain	Myosin_head_motor_dom	MYH6 MYH13 MYO18B	1.37e-03	38	108	3	IPR001609
Domain	MYOSIN_MOTOR	MYH6 MYH13 MYO18B	1.37e-03	38	108	3	PS51456
Domain	Myosin_head	MYH6 MYH13 MYO18B	1.37e-03	38	108	3	PF00063
Domain	MYSc	MYH6 MYH13 MYO18B	1.37e-03	38	108	3	SM00242
Domain	MIR	ITPR1 ITPR2	1.45e-03	10	108	2	PF02815
Domain	MIR_motif	ITPR1 ITPR2	1.45e-03	10	108	2	IPR016093
Domain	MIR	ITPR1 ITPR2	1.45e-03	10	108	2	PS50919
Domain	MIR	ITPR1 ITPR2	1.45e-03	10	108	2	SM00472
Domain	DUF4599	SPATA31D4 SPATA31D3	2.11e-03	12	108	2	PF15371
Domain	DUF4599	SPATA31D4 SPATA31D3	2.11e-03	12	108	2	IPR027970
Domain	Ras_G-nucl-exch_fac_CS	RASGRF1 RAPGEF1	2.88e-03	14	108	2	IPR019804
Domain	Myosin_N	MYH6 MYH13	3.31e-03	15	108	2	PF02736
Domain	Myosin_N	MYH6 MYH13	3.31e-03	15	108	2	IPR004009
Domain	Myosin_tail_1	MYH6 MYH13	4.77e-03	18	108	2	PF01576
Domain	Myosin_tail	MYH6 MYH13	4.77e-03	18	108	2	IPR002928
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	MYBBP1A PDPR POR RNF213 PTPN21 ITPR1 FAN1 ITPR2 GTF2F1 PTPN13 AKAP9 CASKIN2 FDFT1 EFR3B PXN DMD XPOT PCNT	5.40e-09	1049	110	18	27880917
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	HSPG2 NRF1 RAPGEF1 REV3L NPHP4 DCTN1 PLEKHM1 ITPR2 UBN1 CELSR2 NPRL3 NAV2 PXN AKAP13 RIC1 PCNT	4.11e-07	1105	110	16	35748872
Pubmed	A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.	AKAP6 HSPG2 COL6A3 HK2 DCTN1 JMJD1C AKAP9 FDFT1 UGP2 PXN MYO18B	5.43e-07	497	110	11	23414517
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	MYBBP1A PDPR RPN1 POR XRCC5 DCTN1 SNAP47 ITPR1 ITPR2 PJA2 PTPN13 AKAP9 CASKIN2 FDFT1 EFR3B AKAP13 DHX29 PCNT	9.77e-07	1487	110	18	33957083
Pubmed	Bioinformatic design of A-kinase anchoring protein-in silico: a potent and selective peptide antagonist of type II protein kinase A anchoring.	AKAP6 AKAP9 AKAP13	2.55e-06	9	110	3	12672969
Pubmed	Immunolocalization of type 2 inositol 1,4,5-trisphosphate receptors in cardiac myocytes from newborn mice.	ITPR1 ITPR2	9.91e-06	2	110	2	15201137
Pubmed	Sulphide signalling potentiates apoptosis through the up-regulation of IP3 receptor types 1 and 2.	ITPR1 ITPR2	9.91e-06	2	110	2	23582047
Pubmed	Age-dependent changes in diastolic Ca(2+) and Na(+) concentrations in dystrophic cardiomyopathy: Role of Ca(2+) entry and IP3.	ITPR1 DMD	9.91e-06	2	110	2	25242522
Pubmed	The protein arginine methyltransferase family: an update about function, new perspectives and the physiological role in humans.	FBXO10 PRMT9	9.91e-06	2	110	2	19300908
Pubmed	Type 1 and 2 IP3 receptors respond differently to catecholamines and stress.	ITPR1 ITPR2	9.91e-06	2	110	2	19120126
Pubmed	Paxillin family of focal adhesion adaptor proteins and regulation of cancer cell invasion.	TGFB1I1 PXN	9.91e-06	2	110	2	32859368
Pubmed	Platelet-Derived Growth Factor BB Influences Muscle Regeneration in Duchenne Muscle Dystrophy.	PDGFB DMD	9.91e-06	2	110	2	28618254
Pubmed	Roles of paxillin family members in adhesion and ECM degradation coupling at invadosomes.	TGFB1I1 PXN	9.91e-06	2	110	2	27269065
Pubmed	Dermatofibrosarcoma protuberans with a novel COL6A3-PDGFD fusion gene and apparent predilection for breast.	COL6A3 PDGFB	9.91e-06	2	110	2	30014607
Pubmed	An antidepressant behaviour in mice carrying a gene-specific InsP3R1, InsP3R2 and InsP3R3 protein knockdown.	ITPR1 ITPR2	9.91e-06	2	110	2	18708078
Pubmed	Ste20-like protein kinase SLK (LOSK) regulates microtubule organization by targeting dynactin to the centrosome.	SLK DCTN1	9.91e-06	2	110	2	23985322
Pubmed	Deletion of Ku80 causes early aging independent of chronic inflammation and Rag-1-induced DSBs.	RAG1 XRCC5	9.91e-06	2	110	2	17928034
Pubmed	SLK-mediated phosphorylation of paxillin is required for focal adhesion turnover and cell migration.	SLK PXN	9.91e-06	2	110	2	23128389
Pubmed	Distinct roles for paxillin and Hic-5 in regulating breast cancer cell morphology, invasion, and metastasis.	TGFB1I1 PXN	9.91e-06	2	110	2	21148292
Pubmed	Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening.	AKAP6 RAG1 NELFB RAPGEF1 NCKAP5 CELSR2 UGP2 MYO18B	1.05e-05	329	110	8	17474147
Pubmed	Deletion of the Ste20-like kinase SLK in skeletal muscle results in a progressive myopathy and muscle weakness.	SLK PXN DMD	1.09e-05	14	110	3	28153048
Pubmed	Aire's partners in the molecular control of immunological tolerance.	RAG1 MYBBP1A XRCC5 XPOT	1.28e-05	45	110	4	20085707
Pubmed	CTDP1 regulates breast cancer survival and DNA repair through BRCT-specific interactions with FANCI.	RNF213 ITPR1 PTPN13 AKAP13 XPOT	2.07e-05	104	110	5	31240132
Pubmed	E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.	RPN1 NELFB RNF213 REV3L XRCC5 ARHGEF17 ITPR2 TGFB1I1 FRY FBXO10 AKAP13	2.26e-05	736	110	11	29676528
Pubmed	A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning.	SCHIP1 AMER1 APBA3 GMIP TGFB1I1 PJA2 GTF2F1 SEPSECS ARRB2 PELO PXN DMD MRTFA	2.53e-05	1038	110	13	26673895
Pubmed	Characterization of the EGFR interactome reveals associated protein complex networks and intracellular receptor dynamics.	EXOC6 RPN1 ACOT9 RNF213 FDFT1 XPOT	2.66e-05	183	110	6	23956138
Pubmed	Evidence that type I, II, and III inositol 1,4,5-trisphosphate receptors can occur as integral plasma membrane proteins.	ITPR1 ITPR2	2.97e-05	3	110	2	10874040
Pubmed	Abnormal distribution of inositol 1,4,5-trisphosphate receptors in human muscle can be related to altered calcium signals and gene expression in Duchenne dystrophy-derived cells.	ITPR1 ITPR2	2.97e-05	3	110	2	20395455
Pubmed	Inositol 1,4,5-trisphosphate receptors are autoantibody target antigens in patients with Sjögren's syndrome and other systemic rheumatic diseases.	ITPR1 ITPR2	2.97e-05	3	110	2	17437169
Pubmed	Decreased olfactory mucus secretion and nasal abnormality in mice lacking type 2 and type 3 IP3 receptors.	ITPR1 ITPR2	2.97e-05	3	110	2	18547250
Pubmed	Inositol 1,4,5-trisphosphate receptor gene variants are related to the risk of breast cancer in a Chinese population.	ITPR1 ITPR2	2.97e-05	3	110	2	36350267
Pubmed	Inositol 1,4,5-trisphosphate receptors are essential for fetal-maternal connection and embryo viability.	ITPR1 ITPR2	2.97e-05	3	110	2	32320395
Pubmed	The versatility and universality of calcium signalling.	ITPR1 ITPR2	2.97e-05	3	110	2	11413485
Pubmed	Muscle-specific deletion of SLK/Stk2 enhances p38 activity and myogenesis in mdx mice.	SLK DMD	2.97e-05	3	110	2	33259860
Pubmed	Using concatenated subunits to investigate the functional consequences of heterotetrameric inositol 1,4,5-trisphosphate receptors.	ITPR1 ITPR2	2.97e-05	3	110	2	26009177
Pubmed	Receptor-activated single channels in intact human platelets.	ITPR1 ITPR2	2.97e-05	3	110	2	1693919
Pubmed	Functional inositol 1,4,5-trisphosphate receptors assembled from concatenated homo- and heteromeric subunits.	ITPR1 ITPR2	2.97e-05	3	110	2	23955339
Pubmed	Targeted disruption of Ras-Grf2 shows its dispensability for mouse growth and development.	RASGRF1 RAPGEF1	2.97e-05	3	110	2	11909944
Pubmed	Type 3 Inositol 1,4,5-Trisphosphate Receptor is a Crucial Regulator of Calcium Dynamics Mediated by Endoplasmic Reticulum in HEK Cells.	ITPR1 ITPR2	2.97e-05	3	110	2	31979185
Pubmed	Tsg101 regulates PI(4,5)P2/Ca(2+) signaling for HIV-1 Gag assembly.	ITPR1 ITPR2	2.97e-05	3	110	2	24904548
Pubmed	Myotubularin-deficient myoblasts display increased apoptosis, delayed proliferation, and poor cell engraftment.	RAG1 DMD	2.97e-05	3	110	2	22841819
Pubmed	Differential distribution of inositol trisphosphate receptor isoforms in mouse oocytes.	ITPR1 ITPR2	2.97e-05	3	110	2	9858485
Pubmed	Mapping of the binding of platelet-derived growth factor to distinct domains of the basement membrane proteins BM-40 and perlecan and distinction from the BM-40 collagen-binding epitope.	HSPG2 PDGFB	2.97e-05	3	110	2	9692901
Pubmed	Dystrophin and calcium current are decreased in cardiomyocytes expressing Cre enzyme driven by αMHC but not TNT promoter.	MYH6 DMD	2.97e-05	3	110	2	31857666
Pubmed	Expression of inositol 1,4,5-trisphosphate receptors in mouse oocytes and early embryos: the type I isoform is upregulated in oocytes and downregulated after fertilization.	ITPR1 ITPR2	2.97e-05	3	110	2	9808793
Pubmed	Lysine methyltransferase 2D regulates muscle fiber size and muscle cell differentiation.	RAG1 DMD	2.97e-05	3	110	2	34613626
Pubmed	Zn2+ is essential for Ca2+ oscillations in mouse eggs.	ITPR1 TRPV3	2.97e-05	3	110	2	38099643
Pubmed	Type 2 and type 3 inositol 1,4,5-trisphosphate (IP3) receptors promote the differentiation of granule cell precursors in the postnatal cerebellum.	ITPR1 ITPR2	2.97e-05	3	110	2	18194433
Pubmed	Association between polymorphisms in RAPGEF1, TP53, NRF1 and type 2 diabetes in Chinese Han population.	NRF1 RAPGEF1	2.97e-05	3	110	2	21146886
Pubmed	IP3 receptors regulate vascular smooth muscle contractility and hypertension.	ITPR1 ITPR2	2.97e-05	3	110	2	27777977
Pubmed	The adaptor protein paxillin is essential for normal development in the mouse and is a critical transducer of fibronectin signaling.	TGFB1I1 PXN	2.97e-05	3	110	2	11784865
Pubmed	Differential inositol 1,4,5-trisphosphate receptor signaling in a neuronal cell line.	ITPR1 ITPR2	2.97e-05	3	110	2	17581770
Pubmed	Ku80 and p53 suppress medulloblastoma that arise independent of Rag-1-induced DSBs.	RAG1 XRCC5	2.97e-05	3	110	2	16751807
Pubmed	Predominant role of type 1 IP3 receptor in aortic vascular muscle contraction.	ITPR1 ITPR2	2.97e-05	3	110	2	18241669
Pubmed	Granulosa cells express three inositol 1,4,5-trisphosphate receptor isoforms: cytoplasmic and nuclear Ca2+ mobilization.	ITPR1 ITPR2	2.97e-05	3	110	2	19068129
Pubmed	Molecular basis of the isoform-specific ligand-binding affinity of inositol 1,4,5-trisphosphate receptors.	ITPR1 ITPR2	2.97e-05	3	110	2	17327232
Pubmed	Purinergic receptor P2Y12 boosts autoimmune hepatitis through hexokinase 2-dependent glycolysis in T cells.	RAG1 HK2	2.97e-05	3	110	2	37497007
Pubmed	Type 1 inositol (1,4,5)-trisphosphate receptor activates ryanodine receptor 1 to mediate calcium spark signaling in adult mammalian skeletal muscle.	ITPR1 ITPR2	2.97e-05	3	110	2	23223241
Pubmed	Nuclear inositol 1,4,5-trisphosphate receptors regulate local Ca2+ transients and modulate cAMP response element binding protein phosphorylation.	ITPR1 ITPR2	2.97e-05	3	110	2	16014380
Pubmed	Knockdown of the type 2 and 3 inositol 1,4,5-trisphosphate receptors suppresses muscarinic antinociception in mice.	ITPR1 ITPR2	2.97e-05	3	110	2	17890015
Pubmed	Inositol 1, 4, 5-trisphosphate receptors and human left ventricular myocytes.	ITPR1 ITPR2	2.97e-05	3	110	2	23983250
Pubmed	Paxillin family members function as Csk-binding proteins that regulate Lyn activity in human and murine platelets.	TGFB1I1 PXN	2.97e-05	3	110	2	17233630
Pubmed	Interaction of Hic-5, A senescence-related protein, with focal adhesion kinase.	TGFB1I1 PXN	2.97e-05	3	110	2	9756887
Pubmed	Activation of the inositol (1,4,5)-triphosphate calcium gate receptor is required for HIV-1 Gag release.	ITPR1 ITPR2	2.97e-05	3	110	2	20427533
Pubmed	A probability-based approach for high-throughput protein phosphorylation analysis and site localization.	MYBBP1A NELFB GTF2F1 PAN2 NAV2 PXN AKAP13 DHX29 MRTFA	3.29e-05	503	110	9	16964243
Pubmed	DOT1L regulates dystrophin expression and is critical for cardiac function.	HSPG2 MYH6 DMD	3.93e-05	21	110	3	21289070
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	AKAP6 MYBBP1A AMER1 CAMTA2 DCTN1 ITPR1 SEPSECS PTPN13 PAN2 ANKRD12 MRTFA XPOT PCNT	3.96e-05	1084	110	13	11544199
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	SLK HK2 ACOT9 GMIP JMJD1C ITPR1 GTF2F1 CASKIN2 AKAP13 RIC1	4.26e-05	650	110	10	38777146
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	SLK TRO CAMTA2 ARHGEF17 PJA2 AKAP9 ANKRD12 PCNT	4.76e-05	407	110	8	12693553
Pubmed	Loss of IP3R-dependent Ca2+ signalling in thymocytes leads to aberrant development and acute lymphoblastic leukemia.	ITPR1 ITPR2	5.92e-05	4	110	2	25215520
Pubmed	Paxillin and Hic-5 interaction with vinculin is differentially regulated by Rac1 and RhoA.	TGFB1I1 PXN	5.92e-05	4	110	2	22629471
Pubmed	A special population of regulatory T cells potentiates muscle repair.	RAG1 DMD	5.92e-05	4	110	2	24315098
Pubmed	Hic-5-reduced cell spreading on fibronectin: competitive effects between paxillin and Hic-5 through interaction with focal adhesion kinase.	TGFB1I1 PXN	5.92e-05	4	110	2	11463817
Pubmed	EB1 is required for primary cilia assembly in fibroblasts.	DCTN1 PCNT	5.92e-05	4	110	2	17600711
Pubmed	Hic-5 interacts with GIT1 with a different binding mode from paxillin.	TGFB1I1 PXN	5.92e-05	4	110	2	12153727
Pubmed	Hypoxia differently modulates gene expression of inositol 1,4,5-trisphosphate receptors in mouse kidney and HEK 293 cell line.	ITPR1 ITPR2	5.92e-05	4	110	2	19120137
Pubmed	Alternative splice variants of hTrp4 differentially interact with the C-terminal portion of the inositol 1,4,5-trisphosphate receptors.	ITPR1 ITPR2	5.92e-05	4	110	2	11163362
Pubmed	Syndesmos, a syndecan-4 cytoplasmic domain interactor, binds to the focal adhesion adaptor proteins paxillin and Hic-5.	TGFB1I1 PXN	5.92e-05	4	110	2	11805099
Pubmed	Inositol 1, 4, 5-trisphosphate receptor interacts with the SNARE domain of syntaxin 1B.	ITPR1 ITPR2	5.92e-05	4	110	2	21424589
Pubmed	Selective regulation of IP3-receptor-mediated Ca2+ signaling and apoptosis by the BH4 domain of Bcl-2 versus Bcl-Xl.	ITPR1 ITPR2	5.92e-05	4	110	2	21818117
Pubmed	Cell adhesion kinase beta forms a complex with a new member, Hic-5, of proteins localized at focal adhesions.	TGFB1I1 PXN	5.92e-05	4	110	2	9422762
Pubmed	Loss of IP3 Receptor-Mediated Ca2+ Release in Mouse B Cells Results in Abnormal B Cell Development and Function.	ITPR1 ITPR2	5.92e-05	4	110	2	28615414
Pubmed	T cell receptor and cytokine signal integration in CD8+ T cells is mediated by the protein Themis.	RAG1 THEMIS	5.92e-05	4	110	2	31932808
Pubmed	Distinct localization and function of (1,4,5)IP(3) receptor subtypes and the (1,3,4,5)IP(4) receptor GAP1(IP4BP) in highly purified human platelet membranes.	ITPR1 ITPR2	5.92e-05	4	110	2	10828023
Pubmed	Specific dephosphorylation at tyr-554 of git1 by ptprz promotes its association with paxillin and hic-5.	TGFB1I1 PXN	5.92e-05	4	110	2	25742295
Pubmed	Localization of dystrophin gene transcripts during mouse embryogenesis.	MYH6 DMD	5.92e-05	4	110	2	1429837
Pubmed	IP3R-mediated Ca2+ signals govern hematopoietic and cardiac divergence of Flk1+ cells via the calcineurin-NFATc3-Etv2 pathway.	ITPR1 ITPR2	5.92e-05	4	110	2	28419336
Pubmed	IP3R-mediated Ca2+ signaling controls B cell proliferation through metabolic reprogramming.	ITPR1 ITPR2	5.92e-05	4	110	2	35494252
Pubmed	Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.	TRO TGFB1I1 ARRB2 UBN1 AKAP13 RIC1 MRTFA PCNT	6.98e-05	430	110	8	35044719
Pubmed	The FXXLF motif mediates androgen receptor-specific interactions with coregulators.	MYBBP1A TGFB1I1	9.85e-05	5	110	2	11779876
Pubmed	MASTR directs MyoD-dependent satellite cell differentiation during skeletal muscle regeneration.	DMD MRTFA	9.85e-05	5	110	2	22279050
Pubmed	Themis controls thymocyte selection through regulation of T cell antigen receptor-mediated signaling.	RAG1 THEMIS	9.85e-05	5	110	2	19597499
Pubmed	MicroRNA-199a is induced in dystrophic muscle and affects WNT signaling, cell proliferation, and myogenic differentiation.	DMD MRTFA	9.85e-05	5	110	2	23764775
Pubmed	β-arrestin promotes Wnt-induced low density lipoprotein receptor-related protein 6 (Lrp6) phosphorylation via increased membrane recruitment of Amer1 protein.	AMER1 ARRB2	9.85e-05	5	110	2	24265322
Pubmed	LIS1 regulates osteoclast formation and function through its interactions with dynein/dynactin and Plekhm1.	DCTN1 PLEKHM1	9.85e-05	5	110	2	22073305
Pubmed	Role that phosphorylation of GSK3 plays in insulin and Wnt signalling defined by knockin analysis.	H2BW1 H2BW2	9.85e-05	5	110	2	15791206
Pubmed	Interferon-induced mechanosensing defects impede apoptotic cell clearance in lupus.	RAG1 MRTFA	9.85e-05	5	110	2	26098211
Pubmed	GIT1 utilizes a focal adhesion targeting-homology domain to bind paxillin.	TGFB1I1 PXN	9.85e-05	5	110	2	17467235
Pubmed	Chromodomain helicase binding protein 8 (Chd8) is a novel A-kinase anchoring protein expressed during rat cardiac development.	AKAP6 AKAP13	9.85e-05	5	110	2	23071553
Pubmed	Persistent NF-κB activation in muscle stem cells induces proliferation-independent telomere shortening.	XRCC5 DMD	9.85e-05	5	110	2	33979621
GeneFamily	Inositol 1,4,5-triphosphate receptors\|Protein phosphatase 1 regulatory subunits	ITPR1 ITPR2	3.69e-05	3	64	2	297
GeneFamily	Zinc fingers MYND-type\|A-kinase anchoring proteins	AKAP6 AKAP9 AKAP13	1.45e-04	29	64	3	396
GeneFamily	ATP binding cassette subfamily C	ABCC5 ABCC11	9.38e-04	13	64	2	807
GeneFamily	Myosin heavy chains	MYH6 MYH13	1.26e-03	15	64	2	1098
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	RASGRF1 ARHGEF17 AKAP13	1.65e-03	66	64	3	722
GeneFamily	Protein tyrosine phosphatases, non-receptor type	PTPN21 PTPN13	1.82e-03	18	64	2	812
Coexpression	BUYTAERT_PHOTODYNAMIC_THERAPY_STRESS_UP	SLK NRF1 POR ABCC5 CAMTA2 JMJD1C PLEKHM1 BMP2 PJA2 AKAP9 PELO NAV2 ANKRD12 MRTFA	8.11e-06	822	109	14	M6782
Coexpression	JAK2_DN.V1_UP	AKAP6 COL6A3 MYH13 BMP2 NAV2 DMD NEK11	1.18e-05	183	109	7	M2873
Coexpression	GSE28783_ANTI_MIR33_VS_CTRL_ATHEROSCLEROSIS_MACROPHAGE_DN	AKAP6 SCHIP1 RAPGEF1 ARHGEF17 NPHP4 FRY MTUS2	1.96e-05	198	109	7	M8355
Coexpression	GSE11961_MEMORY_BCELL_DAY7_VS_MEMORY_BCELL_DAY40_DN	C3orf62 SESN3 JMJD1C ARRB2 NPRL3 PAN2 DMD	2.09e-05	200	109	7	M9357
ToppCell	COVID-19-Heart-CM_2\|Heart / Disease (COVID-19 only), tissue and cell type	AKAP6 MYH6 NCKAP5 LRRTM3 FRY AKAP13 DMD MYO18B MTUS2	1.43e-09	195	110	9	75fc81bddb246dca3b437fb60827b1d4fe416405
ToppCell	COVID-19-Heart-CM_+_Macrophage\|COVID-19 / Disease (COVID-19 only), tissue and cell type	AKAP6 MYH6 LRRTM3 C4orf54 FRY DMD MYO18B MTUS2	1.04e-08	170	110	8	3f15242a1d3e4e9871d9170b2ef05842fb609c29
ToppCell	COVID-19-Heart-CM_3\|COVID-19 / Disease (COVID-19 only), tissue and cell type	AKAP6 MYH6 LRRTM3 C4orf54 FRY DMD MYO18B MTUS2	1.36e-08	176	110	8	9df7a124ebafb0087da0cda133a394275d7bed81
ToppCell	COVID-19-Heart-CM_3\|Heart / Disease (COVID-19 only), tissue and cell type	AKAP6 NCKAP5 LRRTM3 C4orf54 FRY DMD MYO18B MTUS2	1.77e-08	182	110	8	287fcc3897ae08841f6f85ae6c9cef16f75b1dd1
ToppCell	RV-06._Ventricular_Cardiomyocyte_II\|RV / Chamber and Cluster_Paper	AKAP6 MYH6 NCKAP5 LRRTM3 AKAP13 DMD MYO18B MTUS2	2.47e-08	190	110	8	fe8e78922c8ae928ef9a80bffd67868d5a87a091
ToppCell	COVID-19-Heart-CM_+_EC_+_Pericyte\|Heart / Disease (COVID-19 only), tissue and cell type	AKAP6 MYH6 NCKAP5 LRRTM3 FRY DMD MYO18B MTUS2	2.79e-08	193	110	8	dd5378a1ef8eb0eda9a3aae62f3c2f3a1402bda0
ToppCell	RA-03._Atrial_Cardiomyocyte\|RA / Chamber and Cluster_Paper	AKAP6 MYH6 NCKAP5 LRRTM3 FRY DMD MYO18B MTUS2	2.91e-08	194	110	8	c3535f7cc0076653c72db582047cff053c322397
ToppCell	COVID-19-Heart-CM_+_EC_+_Pericyte\|COVID-19 / Disease (COVID-19 only), tissue and cell type	AKAP6 MYH6 LRRTM3 FRY DMD MYO18B MTUS2	3.41e-07	181	110	7	719eb532453ab7cd7893726885bc75d74a10b21e
ToppCell	COVID-19-Heart-CM_2\|COVID-19 / Disease (COVID-19 only), tissue and cell type	AKAP6 MYH6 LRRTM3 FRY DMD MYO18B MTUS2	3.95e-07	185	110	7	549eeb521c3985bff396ea0f202db21822efa51f
ToppCell	RV-04._Ventricular_Cardiomyocyte_I\|RV / Chamber and Cluster_Paper	AKAP6 MYH6 NCKAP5 LRRTM3 FRY MYO18B MTUS2	4.56e-07	189	110	7	9c1debd65c13d63fd4f3158917d621b44b714c26
ToppCell	RV-15._Ventricular_Cardiomyocyte_III\|World / Chamber and Cluster_Paper	AKAP6 POR NCKAP5 LRRTM3 AKAP13 DMD MYO18B	4.56e-07	189	110	7	0a82931b5f6c0a6427ca3edd5e2235ac49099d40
ToppCell	RV-15._Ventricular_Cardiomyocyte_III\|RV / Chamber and Cluster_Paper	AKAP6 POR NCKAP5 LRRTM3 AKAP13 DMD MYO18B	4.73e-07	190	110	7	93c3188dfeb0b2f9889f8ae9b9c1f2f34129c99b
ToppCell	COVID-19-Heart\|COVID-19 / Disease (COVID-19 only), tissue and cell type	AKAP6 MYH6 LRRTM3 FRY DMD MYO18B MTUS2	4.73e-07	190	110	7	918ad5037881212008f9f69d5df5da91fd01422c
ToppCell	LV-06._Ventricular_Cardiomyocyte_II\|LV / Chamber and Cluster_Paper	AKAP6 MYH6 LRRTM3 AKAP13 DMD MYO18B MTUS2	4.90e-07	191	110	7	25f3eb34f4e70761e81e84c8a5829f216108cbc6
ToppCell	LA-03._Atrial_Cardiomyocyte\|LA / Chamber and Cluster_Paper	AKAP6 MYH6 NCKAP5 LRRTM3 DMD MYO18B MTUS2	4.90e-07	191	110	7	5d1b674eb7703830b7ce8bbeac3363cabd0e6ae9
ToppCell	LV-04._Ventricular_Cardiomyocyte_I\|LV / Chamber and Cluster_Paper	AKAP6 MYH6 NCKAP5 LRRTM3 FRY MYO18B MTUS2	5.07e-07	192	110	7	ad19e2c1d36a0566c9b12ced10db78f4781c8ea6
ToppCell	3'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	AKAP6 TTLL9 C1orf87 SLC9C2 AKAP9 DMD NEK11	6.03e-07	197	110	7	74a2c6cb8fcfe53dd9a2b36492a16c58f38e51c9
ToppCell	3'_v3-lymph-node_spleen-Lymphocytic_T_CD4-T_CD4/CD8\|lymph-node_spleen / Manually curated celltypes from each tissue	THEMIS SESN3 RNF213 JMJD1C AKAP9 ANKRD12	4.26e-06	171	110	6	2e9a20f8980b78325c52065a9c14ab3656267c05
ToppCell	RV-03._Atrial_Cardiomyocyte\|RV / Chamber and Cluster_Paper	AKAP6 MYH6 LRRTM3 DMD MYO18B	6.34e-06	105	110	5	49e16b11f16e83a7d17d162c14bce991201bcc2a
ToppCell	LV-15._Ventricular_Cardiomyocyte_III\|LV / Chamber and Cluster_Paper	AKAP6 LRRTM3 FRY AKAP13 DMD MYO18B	6.49e-06	184	110	6	ab7a1620c14a9d9b6be1b47c559931e345e9eef8
ToppCell	COVID-19-Heart-CM_1\|COVID-19 / Disease (COVID-19 only), tissue and cell type	AKAP6 MYH6 LRRTM3 DMD MYO18B MTUS2	6.49e-06	184	110	6	e737f0f14c49b07bbb04a165083ac32210bc5690
ToppCell	LV-15._Ventricular_Cardiomyocyte_III\|World / Chamber and Cluster_Paper	AKAP6 LRRTM3 FRY DMD MYO18B MTUS2	6.70e-06	185	110	6	6baccb26f999145e51b91d94315bf8d4655bef31
ToppCell	5'-Adult-LargeIntestine-Mesenchymal-fibroblastic-Stromal_2_(NPY+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	COL6A3 REV3L BMP2 PTPN13 PAPPA DMD	7.34e-06	188	110	6	997dcfc4f08738ab398d8abc15e4fd2fc6619862
ToppCell	RV-06._Ventricular_Cardiomyocyte_II\|World / Chamber and Cluster_Paper	AKAP6 LRRTM3 AKAP13 DMD MYO18B MTUS2	7.57e-06	189	110	6	5e80c47f63980904c4c1ff02c201b67b456a0974
ToppCell	LV-06._Ventricular_Cardiomyocyte_II\|World / Chamber and Cluster_Paper	AKAP6 LRRTM3 AKAP13 DMD MYO18B MTUS2	7.80e-06	190	110	6	de5ef606a002f85c2e0e3a36c1f259d0b85a76ff
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Afferent_/_Efferent_Arteriole_Endothelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	EXOC6 HSPG2 PDGFB RAPGEF1 CASKIN2 MMRN2	8.28e-06	192	110	6	3259cb89d6bcf0a3c6ff1f64d85e8a1f54124e91
ToppCell	RA-03._Atrial_Cardiomyocyte\|World / Chamber and Cluster_Paper	AKAP6 MYH6 NCKAP5 DMD MYO18B MTUS2	8.78e-06	194	110	6	89812fb164065041357bb37a3c2d87028ec3de4e
ToppCell	COVID-19-Heart-CM_1\|Heart / Disease (COVID-19 only), tissue and cell type	AKAP6 NCKAP5 LRRTM3 DMD MYO18B MTUS2	9.04e-06	195	110	6	f1ef50331eda8f1239dba6ea970df4eaccf032f1
ToppCell	wk_20-22-Endothelial-Blood_vessel_endothelial-GRIA2+_arterial_endo\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	EXOC6 HSPG2 PDGFB NCKAP5 CASKIN2 MMRN2	9.04e-06	195	110	6	a432d69b0172211ee4d53675936a1dc9ce1ae1f0
ToppCell	wk_15-18-Endothelial-Blood_vessel_endothelial-Late_cap\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	HSPG2 SCHIP1 PDGFB NCKAP5 CASKIN2 MMRN2	9.04e-06	195	110	6	dfc5da514fb34a2c318a5c4c61f44049fa43960e
ToppCell	3'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_II_pneumocyte-AT2-AT2_L.0.1.3.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SPTLC3 WWC3 RASGRF1 BMP2 PTPN13 AKAP13	9.31e-06	196	110	6	7e5addaa844e66f8160e05858c341866a80aed23
ToppCell	LPS_IL1RA_TNF-Mesenchymal_myocytic\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	AKAP6 ARHGEF17 ITPR1 TGFB1I1 PELO DMD	1.04e-05	200	110	6	f599e4b051ac3dad11ad437e98dc8ea6754cca53
ToppCell	LPS_IL1RA-Mesenchymal_myocytic-Pericyte-Pericyte_3\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	AKAP6 ARHGEF17 ITPR1 TGFB1I1 PELO DMD	1.04e-05	200	110	6	a3a1e35934d676c39f917652e50c502cb2f613c1
ToppCell	10x5'v1-week_14-16-Mesenchymal_osteo-stroma-osteochondral_precursor\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	COL6A3 ARHGEF17 TGFB1I1 PTPN13 MMRN2 PAPPA	1.04e-05	200	110	6	ad3fb8ef0be45032369d1325024787fbe1dfb8d6
ToppCell	LPS_only-Mesenchymal_myocytic-Pericyte-Pericyte_3\|LPS_only / Treatment groups by lineage, cell group, cell type	AKAP6 ARHGEF17 TGFB1I1 PELO DMD MYO18B	1.04e-05	200	110	6	7c62678cf408aaaf98d6df0fb27814d2007c4521
ToppCell	LPS_IL1RA-Mesenchymal_myocytic\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	AKAP6 ARHGEF17 ITPR1 TGFB1I1 PELO DMD	1.04e-05	200	110	6	77631c471cc5d453a749784f838cfa6408caf09b
ToppCell	10x5'-Lung-Myeloid_Mac-Intestinal_macrophages\|Lung / Manually curated celltypes from each tissue	AKAP6 SPTLC3 NCKAP5 PTPN21 ARHGEF17	2.65e-05	141	110	5	7671d300b1722711fd2d8034b96a3aa7e3ccb560
ToppCell	TCGA-Bone_and_Soft_Tissue-Primary_Tumor-Sarcoma-Conventional_Leiomyosarcoma\|TCGA-Bone_and_Soft_Tissue / Sample_Type by Project: Shred V9	AKAP6 ITPR1 TGFB1I1 CELSR2 DMD	3.91e-05	153	110	5	ec6fe6b8c884fa76adc7a0f9db041f7b1567a2ee
ToppCell	facs-Marrow-KLS-3m-Lymphocytic-BM_CD8_+_CD4_T_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	THEMIS PDPR SESN3 PELO TRIM62	4.70e-05	159	110	5	e967b557fe6ae4879d36f62c0297cbf6a2ad1ce9
ToppCell	facs-Marrow-KLS-3m-Lymphocytic-mature_alpha-beta_T_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	THEMIS PDPR SESN3 PELO TRIM62	4.70e-05	159	110	5	9db971130509c62d439e0cab16588a4d994d7aa0
ToppCell	LPS-IL1RA+antiTNF-Epithelial_alveolar-Mes-like\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	AKAP6 MYBBP1A NIF3L1 PITPNM1 BMP2	5.29e-05	163	110	5	360cd65decda24853124f33a174f5224d7f3ce23
ToppCell	LPS-IL1RA+antiTNF-Epithelial_alveolar-Mes-like-AT1_Progenitor\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	AKAP6 MYBBP1A NIF3L1 PITPNM1 BMP2	5.29e-05	163	110	5	b59d9b4f7c9f4e5e2c7783a49a96729dae3a81e5
ToppCell	343B-Epithelial_cells-Epithelial-A_(AT2)-\|343B / Donor, Lineage, Cell class and subclass (all cells)	WWC3 RASGRF1 TMEM87A PTPN13 AKAP13	5.44e-05	164	110	5	beaa13a75c3bb72446c85084d75e9fe3f15fd3d4
ToppCell	343B-Epithelial_cells-Epithelial-A_(AT2)\|343B / Donor, Lineage, Cell class and subclass (all cells)	WWC3 RASGRF1 TMEM87A PTPN13 AKAP13	5.44e-05	164	110	5	d005cfd821b87548b075120bffe65a0be9860463
ToppCell	droplet-Thymus-nan-24m-Lymphocytic-double_negative_T_cell\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BEND4 ARHGEF17 PAN2 PRMT9 MTUS2	6.10e-05	168	110	5	de1042267407719f19eb3f580a5df0c9cd0e8273
ToppCell	3'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_I_pneumocyte-AT1-AT1_L.0.5.1.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	HSPG2 SCHIP1 NCKAP5 PTPN21 EFR3B	6.27e-05	169	110	5	cd16e8462ee09877be962fbd9a3badcb825820b0
ToppCell	E16.5-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_prolif\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	EXOC6 HSPG2 PDGFB FAN1 MMRN2	6.45e-05	170	110	5	55fe16d98ea284d05fb899888e4569c685644c7b
ToppCell	droplet-Liver-LIVER-NPC-1m-Endothelial-Hepatocyte_(Pericentral)\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HSPG2 XRCC5 BMP2 PELO CASKIN2	7.40e-05	175	110	5	98dc3b6f69a29d587f503898f09912700950e3d9
ToppCell	facs-Heart-RV-24m-Mesenchymal-ventricular_myocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYH6 NTMT2 SPATA31D3 MYO18B MTUS2	7.81e-05	177	110	5	692cd03bf0958ebeec34d41bfe87713a768e9a8e
ToppCell	facs-Heart-RV-24m-Mesenchymal-ventricular_cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYH6 NTMT2 SPATA31D3 MYO18B MTUS2	7.81e-05	177	110	5	c08583ea68bbeb6b5de852a46b0c0f04792dae55
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell-Multiciliated_(nasal)-Multiciliated_(nasal)_L.0.3.1.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	AKAP6 TTLL9 SLC9C2 PITPNM1 NEK11	8.02e-05	178	110	5	3b12db04006db6e94fc45649a4b3a63b92f21a61
ToppCell	COVID-19-Heart-CM_4\|COVID-19 / Disease (COVID-19 only), tissue and cell type	AKAP6 ABCC5 LRRTM3 DMD MYO18B	9.13e-05	183	110	5	2902b6e8aa9a6f62bc1a792c971ab7f651a8e676
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Outer_Medullary_Collecting_Duct_Principal_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	C4orf54 FRY PTPN13 PAPPA MYO18B	9.13e-05	183	110	5	b5ede5a0048c585b73c00e88aeddbcaf669347b1
ToppCell	LPS-IL1RA-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_2\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	COL6A3 ARHGEF17 TGFB1I1 PELO DMD	9.37e-05	184	110	5	102b6f621a5b551e622f97b12d787c080b052a72
ToppCell	droplet-Liver-LIVER_HEP-30m-Endothelial-nan\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HSPG2 BEND4 BMP2 PTPN13 MMRN2	9.61e-05	185	110	5	bdd2e6cb20294b39a9d856004bf57ba69cf877e2
ToppCell	5'-GW_trimst-1.5-LargeIntestine-Endothelial-blood_vessel_EC-Fetal_venous_EC\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	EXOC6 HSPG2 PDGFB FRY MMRN2	9.86e-05	186	110	5	055cc23c4db9aad2d6c62e62c8e58bfe5047c6b1
ToppCell	ILEUM-inflamed-(3)_MNP-(3)_moDC\|(3)_MNP / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	REV3L JMJD1C ITPR2 AKAP9 AKAP13	1.01e-04	187	110	5	0099def970fbc828756fbf853eca2ce77b8cd342
ToppCell	3'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_II_pneumocyte-AT2-AT2_L.0.1.1.3\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	WWC3 RASGRF1 BMP2 PTPN13 AKAP13	1.01e-04	187	110	5	7c44cec1c26ca5907a495f2d7e633410e2e9728f
ToppCell	LA-03._Atrial_Cardiomyocyte\|World / Chamber and Cluster_Paper	AKAP6 MYH6 NCKAP5 DMD MYO18B	1.04e-04	188	110	5	6d249fe92d51a19da19ec14bb2262d394255d577
ToppCell	wk_15-18-Endothelial-Blood_vessel_endothelial-GRIA2+_arterial_endo\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	EXOC6 HSPG2 PDGFB NCKAP5 MMRN2	1.04e-04	188	110	5	366a2d59b9c81d8a7659749f9c07efa46b49a39a
ToppCell	droplet-Liver-LIVER_NPC-30m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HSPG2 SCHIP1 LRRTM3 BMP2 MMRN2	1.04e-04	188	110	5	0aa8747c2931b0c91f6d78bb2db8fd8ede6dd559
ToppCell	facs-Heart-LV-18m-Endothelial-endothelial_cell_of_coronary_artery\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HSPG2 PDGFB CASKIN2 EFR3B MMRN2	1.04e-04	188	110	5	ed11e26ff4ef3d6314b5f5734062519b9aa285c1
ToppCell	AT1-AT2_cells-Donor_01\|World / lung cells shred on cell class, cell subclass, sample id	SCHIP1 NCKAP5 PTPN21 BMP2 EFR3B	1.04e-04	188	110	5	be710bc957118cf426dd71c2d57e6f1b41c9a467
ToppCell	facs-Heart-LV-18m-Endothelial-coronary_vascular_endothelial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HSPG2 PDGFB CASKIN2 EFR3B MMRN2	1.04e-04	188	110	5	e5a8ca4613ab0bf1584b9e78959adf41d0bf379f
ToppCell	Substantia_nigra-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	BEND4 PJA2 DBNDD1 PAPPA EPHA10	1.04e-04	188	110	5	b73e8a40393c3f656e2fcfe395a761b1f985c254
ToppCell	facs-Heart-LV-18m-Endothelial\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HSPG2 PDGFB CASKIN2 EFR3B MMRN2	1.04e-04	188	110	5	0fc3a6562e6895f6fe7a93397eae842a75c60c93
ToppCell	5'-GW_trimst-2-LargeIntestine-Endothelial-blood_vessel_EC-Fetal_arterial_EC\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	HSPG2 SCHIP1 PDGFB CASKIN2 MMRN2	1.06e-04	189	110	5	db09d591b885ce2bc9e353f08b6694e2192582e1
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	AKAP6 ARHGEF17 FRY DMD MYO18B	1.06e-04	189	110	5	127ad2ba3e794df8cce2eee3e4171bccb5aad51b
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	AKAP6 ARHGEF17 FRY DMD MYO18B	1.06e-04	189	110	5	2cfb4d12f75678d1619f4743838a0e954bd57761
ToppCell	droplet-Liver-LIVER_NPC-30m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HSPG2 SCHIP1 LRRTM3 BMP2 MMRN2	1.09e-04	190	110	5	a08c5929b05a4969852e351a93c4e4deb4c8d5b6
ToppCell	COVID-19-Heart-CM_4\|Heart / Disease (COVID-19 only), tissue and cell type	AKAP6 POR ABCC5 UGP2 MYO18B	1.09e-04	190	110	5	3729648a17093b438398b82e32bbccc3af7b8c5d
ToppCell	droplet-Liver-LIVER_NPC-30m-Endothelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HSPG2 SCHIP1 LRRTM3 BMP2 MMRN2	1.09e-04	190	110	5	25525fee1da8a808034d9c916159fd0b6b26bce8
ToppCell	facs-SCAT-Fat-3m-Endothelial-nan\|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PDGFB FRY CASKIN2 EFR3B MMRN2	1.12e-04	191	110	5	a0018f88f7132477cc467ee15db029a585290595
ToppCell	(1)_T_CD4_fh\|World / Spleen cell shreds - cell class (v1) and cell subclass (v1)	THEMIS PTPN13 UGP2 AKAP13 ANKRD12	1.12e-04	191	110	5	66ddff9a99092cb384b9fb2a3ba95ddbebed67cc
ToppCell	LPS-IL1RA-Stromal_mesenchymal-Lung_smooth_muscle\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	COL6A3 ARHGEF17 ITPR1 TGFB1I1 DMD	1.12e-04	191	110	5	7853ac7dff649150e6ff27cd4c8cf7c1fc034ed4
ToppCell	nucseq-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Ciliated\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	TTLL9 C1orf87 TTC34 SLC9C2 NEK11	1.12e-04	191	110	5	e417bf491f8b8d7838a61f7f4f6b1740ba97aa3f
ToppCell	facs-SCAT-Fat-3m-Endothelial-endothelial_cell\|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PDGFB FRY CASKIN2 EFR3B MMRN2	1.12e-04	191	110	5	6b9bbf4a63d4e9a8075bb06c2aa644fcf4ee88b8
ToppCell	facs-SCAT-Fat-3m-Endothelial\|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PDGFB FRY CASKIN2 EFR3B MMRN2	1.12e-04	191	110	5	90f0c193dce267a4f1a9b2501f636dafd0a34cf7
ToppCell	nucseq-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	TTLL9 C1orf87 TTC34 SLC9C2 NEK11	1.12e-04	191	110	5	9d31c8424d35bdc0c27188b68bfd0f731af3600b
ToppCell	nucseq-Epithelial-Epithelial_Airway\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	TTLL9 C1orf87 TTC34 SLC9C2 NEK11	1.12e-04	191	110	5	1c528f72c9ef3ef3a850b05e4a9715190832270c
ToppCell	droplet-Heart-nan-24m-Mesenchymal-cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	AKAP6 MYH6 SPATA31D3 MYO18B MTUS2	1.14e-04	192	110	5	f6a4e348406a852ace9fb21db8fbdff539217645
ToppCell	droplet-Heart-nan-24m-Mesenchymal-atrial_cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	AKAP6 MYH6 SPATA31D3 MYO18B MTUS2	1.14e-04	192	110	5	1a0c25106ae08eac912a4edd5fc1a3ee776f69c2
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	EXOC6 HSPG2 PDGFB EFR3B MMRN2	1.14e-04	192	110	5	56b021c297a21dff357531f21e2464f85186106d
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Degenerative_Outer_Medullary_Collecting_Duct_Principal_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	C4orf54 FRY PTPN13 CELSR2 PAPPA	1.20e-04	194	110	5	d602a0cdb69cd5a3e9ef61ddbab8d920557dd73e
ToppCell	367C-Myeloid-Macrophage-M2-like_Macrophage_(MARCO_negative)\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	AKAP6 ABCC5 NCKAP5 ITPR2 NAV2	1.23e-04	195	110	5	4008fa86b5166087a4b20f89ae07e1dfc87c855d
ToppCell	3'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_II_pneumocyte-AT2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	WWC3 RASGRF1 BMP2 PTPN13 AKAP13	1.23e-04	195	110	5	6617abca0009ad3d8731f515f91ab275f9ea4c40
ToppCell	356C-Epithelial_cells-Epithelial-I_(AT1)\|356C / Donor, Lineage, Cell class and subclass (all cells)	HSPG2 NCKAP5 PTPN21 EFR3B NAV2	1.23e-04	195	110	5	07a3ef6b0f1201fe2bcb9ea426b8f7a69beb4904
ToppCell	cellseq-Epithelial-Epithelial_Alveolar-AT2-AT2\|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	RASGRF1 TMEM87A BMP2 PTPN13 AKAP13	1.23e-04	195	110	5	6867f9c56ea27a17c8c4099aae0d79903c3748a5
ToppCell	10x5'v1-week_14-16-Lymphocytic_B-B_lineage-pro_B_progenitor\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	RAG1 SCHIP1 JMJD1C ITPR1 RIC1	1.23e-04	195	110	5	dc84a910b6f6eb9994cd683aa4fd813a82198e5f
ToppCell	3'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_II_pneumocyte\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	WWC3 RASGRF1 BMP2 PTPN13 AKAP13	1.23e-04	195	110	5	fc0ae145a2118df7cbbc9ac4ca9dc12d26c087c4
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	EXOC6 HSPG2 PDGFB RAPGEF1 MMRN2	1.23e-04	195	110	5	d35102f95bb1e419d2df05ff0a01b6c5c923acef
ToppCell	cellseq-Epithelial-Epithelial_Alveolar-AT2\|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	RASGRF1 TMEM87A BMP2 PTPN13 AKAP13	1.23e-04	195	110	5	955a0a7244cd7eaf006a39e1bd03333baf6f30a4
ToppCell	RA-02._Fibroblast_II\|RA / Chamber and Cluster_Paper	COL6A3 REV3L NAV2 PAPPA MRTFA	1.23e-04	195	110	5	6a02ebbeb3199447ddce64d92d8809436e040eba
ToppCell	356C-Epithelial_cells-Epithelial-I_(AT1)-\|356C / Donor, Lineage, Cell class and subclass (all cells)	HSPG2 NCKAP5 PTPN21 EFR3B NAV2	1.23e-04	195	110	5	b65511770ed67f7447847e2187555b362988af45
ToppCell	5'-Adult-SmallIntestine-Mesenchymal-Pericytes-Contractile_pericyte_(PLN+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	AKAP6 ARHGEF17 TGFB1I1 FRY DMD	1.26e-04	196	110	5	ce6f7ddb8104471dc90347f427486379914d63b4
ToppCell	facs-Trachea\|facs / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	HSPG2 COL6A3 HK2 JMJD1C BMP2	1.26e-04	196	110	5	8209f2b0f7efebaaf81d642d18a1aee8a9a8dcf6
ToppCell	3'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_I_pneumocyte-AT1-AT1_L.0.5.0.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	HSPG2 NCKAP5 PTPN21 EFR3B NAV2	1.26e-04	196	110	5	eb68f7954e7c2f86d05e740e95b6e74805a6053f
ToppCell	5'-Adult-SmallIntestine-Mesenchymal-Pericytes\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	AKAP6 ARHGEF17 TGFB1I1 FRY DMD	1.26e-04	196	110	5	6d7179decea512dd49bb2d5f6a4f5989349d52a9
ToppCell	5'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_II_pneumocyte-AT2-AT2_L.0.1.0.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	RASGRF1 TMEM87A BMP2 PTPN13 AKAP13	1.26e-04	196	110	5	65e161fd672e37a5d10f28011bb422c4d7042d6a
ToppCell	RA-02._Fibroblast_II\|World / Chamber and Cluster_Paper	COL6A3 REV3L NAV2 PAPPA MRTFA	1.26e-04	196	110	5	e8cbda03837f1f26470a9d93aa7fdaa04e08e38a
Computational	Neighborhood of BMI1	RPN1 NELFB PITPNM1 GTF2F1 ZPR1	1.24e-04	81	65	5	MORF_BMI1
Drug	Sulfamethoxazole [723-46-6]; Down 200; 15.8uM; PC3; HT_HG-U133A	SPTLC3 HSPG2 MYBBP1A APBA3 NPHP4 AKAP9 CASKIN2 TRIM62 PXN	4.42e-07	198	108	9	7366_DN
Disease	Hypoxic Brain Damage	ITPR1 ITPR2	1.21e-05	2	103	2	C1140716
Disease	Anoxic Encephalopathy	ITPR1 ITPR2	1.21e-05	2	103	2	C0003132
Disease	Brain Hypoxia	ITPR1 ITPR2	1.21e-05	2	103	2	C1527348
Disease	Anoxia of brain	ITPR1 ITPR2	1.21e-05	2	103	2	C0995195
Disease	atrial fibrillation	AKAP6 HSPG2 MYH6 JMJD1C ITPR2 NAV2 PAPPA MYO18B	4.87e-05	371	103	8	EFO_0000275
Disease	total lipids in VLDL measurement	EXOC6 JMJD1C CELSR2 ZPR1	5.88e-05	60	103	4	EFO_0022314
Disease	uterine fibroid	SLK THEMIS ITPR1 ANKRD12 MYO18B MRTFA	7.25e-05	199	103	6	EFO_0000731
Disease	cholesterol in large VLDL measurement	EXOC6 JMJD1C CELSR2 ZPR1	8.05e-05	65	103	4	EFO_0021902
Disease	total lipids in large VLDL	EXOC6 JMJD1C CELSR2 ZPR1	9.06e-05	67	103	4	EFO_0022175
Disease	free cholesterol in large VLDL measurement	EXOC6 JMJD1C CELSR2 ZPR1	9.60e-05	68	103	4	EFO_0022265
Disease	cholesteryl esters to total lipids in large LDL percentage	JMJD1C CELSR2 ZPR1	1.73e-04	31	103	3	EFO_0022249
Disease	Paroxysmal atrial fibrillation	AKAP6 HSPG2 MYH6 NAV2 MYO18B	2.23e-04	156	103	5	C0235480
Disease	familial atrial fibrillation	AKAP6 HSPG2 MYH6 NAV2 MYO18B	2.23e-04	156	103	5	C3468561
Disease	Persistent atrial fibrillation	AKAP6 HSPG2 MYH6 NAV2 MYO18B	2.23e-04	156	103	5	C2585653
Disease	multiple sclerosis	NLRP11 EXOC6 THEMIS RASGRF1 NCKAP5 TTC34 ITPR1 SEPSECS AKAP13	2.39e-04	594	103	9	MONDO_0005301
Disease	beta-citrylglutamate measurement	ABCC5 JMJD1C	2.51e-04	7	103	2	EFO_0800060
Disease	Atrial Fibrillation	AKAP6 HSPG2 MYH6 NAV2 MYO18B	2.51e-04	160	103	5	C0004238
Disease	chylomicron measurement, very low density lipoprotein cholesterol measurement, lipid measurement	EXOC6 JMJD1C FDFT1 ZPR1	3.49e-04	95	103	4	EFO_0004529, EFO_0008317, EFO_0008596
Disease	chylomicron measurement, triglyceride measurement, very low density lipoprotein cholesterol measurement	EXOC6 JMJD1C FDFT1 ZPR1	3.64e-04	96	103	4	EFO_0004530, EFO_0008317, EFO_0008596
Disease	lipoprotein-associated phospholipase A(2) measurement	RNF213 CELSR2 ZPR1	3.72e-04	40	103	3	EFO_0004746
Disease	Abnormality of the face	FDFT1 UGP2	4.28e-04	9	103	2	C4025871
Disease	retinal vasculature measurement	EXOC6 HSPG2 PDGFB NCKAP5 ITPR1 BMP2 FRY MRTFA	4.67e-04	517	103	8	EFO_0010554
Disease	cholesterol to total lipids in large VLDL percentage	JMJD1C CELSR2 ZPR1	5.27e-04	45	103	3	EFO_0022236
Disease	chylomicron measurement, very low density lipoprotein cholesterol measurement	EXOC6 JMJD1C FDFT1 ZPR1	5.29e-04	106	103	4	EFO_0008317, EFO_0008596
Disease	autosomal dominant hyaline body myopathy (implicated_via_orthology)	MYH6 MYH13	5.33e-04	10	103	2	DOID:0111269 (implicated_via_orthology)
Disease	distal arthrogryposis type 2B3 (implicated_via_orthology)	MYH6 MYH13	5.33e-04	10	103	2	DOID:0111602 (implicated_via_orthology)
Disease	diabetes mellitus biomarker	EXOC6 RASGRF1	5.33e-04	10	103	2	EFO_0006842
Disease	distal arthrogryposis type 1 (implicated_via_orthology)	MYH6 MYH13	5.33e-04	10	103	2	DOID:0111596 (implicated_via_orthology)
Disease	dilated cardiomyopathy 1S (implicated_via_orthology)	MYH6 MYH13	5.33e-04	10	103	2	DOID:0110454 (implicated_via_orthology)
Disease	congenital myopathy 6 (implicated_via_orthology)	MYH6 MYH13	5.33e-04	10	103	2	DOID:0080719 (implicated_via_orthology)
Disease	inclusion body myositis (implicated_via_orthology)	MYH6 MYH13	5.33e-04	10	103	2	DOID:3429 (implicated_via_orthology)
Disease	fear of medical pain measurement	THEMIS WWC3	5.33e-04	10	103	2	EFO_0008339
Disease	distal arthrogryposis type 2A (implicated_via_orthology)	MYH6 MYH13	5.33e-04	10	103	2	DOID:0111605 (implicated_via_orthology)
Disease	familial hypertrophic cardiomyopathy (implicated_via_orthology)	MYH6 MYH13	5.33e-04	10	103	2	DOID:0080326 (implicated_via_orthology)
Disease	chylomicron measurement, very low density lipoprotein cholesterol measurement, phospholipid measurement	EXOC6 JMJD1C FDFT1 ZPR1	5.88e-04	109	103	4	EFO_0004639, EFO_0008317, EFO_0008596
Disease	cholesteryl ester measurement, chylomicron measurement, very low density lipoprotein cholesterol measurement	EXOC6 JMJD1C FDFT1 ZPR1	6.09e-04	110	103	4	EFO_0008317, EFO_0008596, EFO_0010351
Disease	free cholesterol measurement, chylomicron measurement, very low density lipoprotein cholesterol measurement	EXOC6 JMJD1C FDFT1 ZPR1	6.09e-04	110	103	4	EFO_0008317, EFO_0008591, EFO_0008596
Disease	chylomicron measurement, total cholesterol measurement, very low density lipoprotein cholesterol measurement	EXOC6 JMJD1C FDFT1 ZPR1	6.09e-04	110	103	4	EFO_0004574, EFO_0008317, EFO_0008596
Disease	cholesteryl esters to total lipids in small VLDL percentage	JMJD1C CELSR2 ZPR1	6.77e-04	49	103	3	EFO_0022256
Disease	triglycerides to total lipids in medium LDL percentage	JMJD1C CELSR2 ZPR1	7.19e-04	50	103	3	EFO_0022334
Disease	free cholesterol in large LDL measurement	JMJD1C PELO CELSR2	7.62e-04	51	103	3	EFO_0022176
Disease	triglycerides to total lipids in large LDL percentage	JMJD1C CELSR2 ZPR1	7.62e-04	51	103	3	EFO_0022331
Disease	cholesterol to total lipids in small VLDL percentage	JMJD1C CELSR2 ZPR1	7.62e-04	51	103	3	EFO_0022242
Disease	autosomal dominant cerebellar ataxia (implicated_via_orthology)	ITPR1 ITPR2	7.78e-04	12	103	2	DOID:1441 (implicated_via_orthology)
Disease	distal myopathy (implicated_via_orthology)	MYH6 MYH13	7.78e-04	12	103	2	DOID:11720 (implicated_via_orthology)
Disease	myotonia congenita (implicated_via_orthology)	MYH6 MYH13	7.78e-04	12	103	2	DOID:2106 (implicated_via_orthology)
Disease	omega-3 polyunsaturated fatty acid measurement	JMJD1C CELSR2 FDFT1 ZPR1	7.92e-04	118	103	4	EFO_0010119
Disease	triglycerides to total lipids in very large VLDL percentage	JMJD1C CELSR2 ZPR1	8.52e-04	53	103	3	EFO_0022340
Disease	free cholesterol to total lipids in small LDL percentage	JMJD1C CELSR2 ZPR1	8.52e-04	53	103	3	EFO_0022286
Disease	cholesteryl esters to total lipids in very large VLDL percentage	JMJD1C CELSR2 ZPR1	8.52e-04	53	103	3	EFO_0022258
Disease	cholesterol to total lipids in very large VLDL percentage	JMJD1C CELSR2 ZPR1	9.00e-04	54	103	3	EFO_0022244
Disease	restrictive cardiomyopathy (implicated_via_orthology)	MYH6 MYH13	9.18e-04	13	103	2	DOID:397 (implicated_via_orthology)
Disease	triacylglycerol 52:2 measurement	NCKAP5 SEPSECS ZPR1	9.50e-04	55	103	3	EFO_0010414
Disease	triglycerides in very large VLDL measurement	EXOC6 JMJD1C ZPR1	1.00e-03	56	103	3	EFO_0022325
Disease	cholesteryl esters to total lipids in large VLDL percentage	JMJD1C CELSR2 ZPR1	1.00e-03	56	103	3	EFO_0022250
Disease	free cholesterol to total lipids in medium VLDL percentage	JMJD1C CELSR2 ZPR1	1.05e-03	57	103	3	EFO_0022284
Disease	triglycerides to total lipids in small VLDL percentage	JMJD1C CELSR2 ZPR1	1.11e-03	58	103	3	EFO_0022338
Disease	triglycerides in VLDL measurement	EXOC6 JMJD1C ZPR1	1.17e-03	59	103	3	EFO_0022326
Disease	triglycerides to total lipids in small LDL percentage	JMJD1C CELSR2 ZPR1	1.17e-03	59	103	3	EFO_0022337
Disease	phospholipids in VLDL measurement	EXOC6 CELSR2 ZPR1	1.17e-03	59	103	3	EFO_0022301
Disease	free cholesterol to total lipids in very large VLDL percentage	JMJD1C CELSR2 ZPR1	1.17e-03	59	103	3	EFO_0022289
Disease	hypertension (biomarker_via_orthology)	HSPG2 HK2 PDGFB BMP2 ARRB2	1.22e-03	227	103	5	DOID:10763 (biomarker_via_orthology)
Disease	distal arthrogryposis (implicated_via_orthology)	MYH6 MYH13	1.23e-03	15	103	2	DOID:0050646 (implicated_via_orthology)
Disease	Myopia	RASGRF1 BMP2	1.23e-03	15	103	2	C0027092
Disease	free cholesterol in very large VLDL measurement	EXOC6 JMJD1C ZPR1	1.28e-03	61	103	3	EFO_0022274
Disease	free cholesterol in VLDL measurement	EXOC6 CELSR2 ZPR1	1.28e-03	61	103	3	EFO_0022276
Disease	platelet component distribution width	EXOC6 MYH13 NRF1 RPN1 ABCC5 JMJD1C C4orf54 ZPR1 AKAP13	1.32e-03	755	103	9	EFO_0007984
Disease	phospholipids in large VLDL measurement	EXOC6 JMJD1C ZPR1	1.35e-03	62	103	3	EFO_0022169
Disease	total lipids in very large VLDL measurement	EXOC6 JMJD1C ZPR1	1.35e-03	62	103	3	EFO_0022313
Disease	phospholipids in very large VLDL measurement	EXOC6 JMJD1C ZPR1	1.35e-03	62	103	3	EFO_0022299
Disease	triglycerides to total lipids in IDL percentage	JMJD1C CELSR2 ZPR1	1.41e-03	63	103	3	EFO_0022329
Disease	triglycerides to total lipids in medium VLDL percentage	JMJD1C CELSR2 ZPR1	1.41e-03	63	103	3	EFO_0022335
Disease	cholesterol to total lipids in medium VLDL percentage	JMJD1C CELSR2 ZPR1	1.41e-03	63	103	3	EFO_0022239
Disease	cholesteryl esters to total lipids in medium VLDL percentage	JMJD1C CELSR2 ZPR1	1.47e-03	64	103	3	EFO_0022253
Disease	cholesterol in very large VLDL measurement	EXOC6 CELSR2 ZPR1	1.54e-03	65	103	3	EFO_0022230
Disease	Moyamoya Disease	RNF213 PCNT	1.59e-03	17	103	2	C0026654
Disease	cortical thickness	AKAP6 HSPG2 NCKAP5 TTC34 JMJD1C PLEKHM1 BMP2 SEPSECS UBN1 FBXO42 NAV2	1.76e-03	1113	103	11	EFO_0004840
Disease	sphingosine 1-phosphate measurement	ITPR1 DMD	1.78e-03	18	103	2	EFO_0800185
Disease	very low density lipoprotein cholesterol measurement, esterified cholesterol measurement	CELSR2 ZPR1	1.78e-03	18	103	2	EFO_0008317, EFO_0008589
Disease	triglycerides to total lipids in very small VLDL percentage	JMJD1C CELSR2 ZPR1	1.83e-03	69	103	3	EFO_0022341
Disease	carotid artery disease (is_marker_for)	HSPG2 PAPPA	1.99e-03	19	103	2	DOID:3407 (is_marker_for)
Disease	sodium-coupled monocarboxylate transporter 1 measurement	CELSR2 ZPR1	1.99e-03	19	103	2	EFO_0802076
Disease	low density lipoprotein cholesterol measurement, phospholipids:total lipids ratio	EXOC6 CELSR2 FDFT1 ZPR1	2.06e-03	153	103	4	EFO_0004611, EFO_0020946
Disease	low density lipoprotein cholesterol measurement, cholesteryl esters:total lipids ratio	EXOC6 CELSR2 FDFT1 ZPR1	2.06e-03	153	103	4	EFO_0004611, EFO_0020944
Disease	very low density lipoprotein cholesterol measurement	EXOC6 JMJD1C CELSR2 FDFT1 ZPR1	2.22e-03	260	103	5	EFO_0008317
Disease	free cholesterol to total lipids in large LDL percentage	JMJD1C CELSR2 ZPR1	2.24e-03	74	103	3	EFO_0022280
Disease	free cholesterol to total lipids in small VLDL percentage	JMJD1C CELSR2 ZPR1	2.32e-03	75	103	3	EFO_0022287
Disease	very low density lipoprotein cholesterol measurement, cholesteryl esters:total lipids ratio	JMJD1C PELO CELSR2 FDFT1 ZPR1	2.37e-03	264	103	5	EFO_0008317, EFO_0020944
Disease	docosahexaenoic acid to total fatty acids percentage	JMJD1C ZPR1	2.43e-03	21	103	2	EFO_0022262
Disease	white matter microstructure measurement	SLK ABCC5 NCKAP5 PLEKHM1 FDFT1 NAV2	2.50e-03	390	103	6	EFO_0005674
Disease	Abnormality of refraction	AKAP6 RASGRF1 BEND4 DCTN1 ITPR2 BMP2 FRY AKAP13	2.50e-03	673	103	8	HP_0000539
Disease	dyslexia	C1orf87 PTPN21 MYO18B AFG1L	2.54e-03	162	103	4	EFO_0005424
Disease	dilated cardiomyopathy (implicated_via_orthology)	MYH6 MYH13 DMD	2.79e-03	80	103	3	DOID:12930 (implicated_via_orthology)
Disease	sphingomyelin measurement	SPTLC3 CAMTA2 JMJD1C CELSR2 ZPR1	2.96e-03	278	103	5	EFO_0010118
Disease	coronary artery disease	EXOC6 COL6A3 SLK RNF213 TTC34 CELSR2 ZPR1 NPRL3 PAN2 AKAP13 MRTFA	3.03e-03	1194	103	11	EFO_0001645
Disease	Left ventricular mass to end-diastolic volume ratio	PXN MYO18B	3.44e-03	25	103	2	EFO_0010556
Disease	large artery stroke, coronary artery disease	CELSR2 ZPR1	3.44e-03	25	103	2	EFO_0001645, EFO_0005524

Protein segments in the cluster

Peptide	Gene	Start	Entry
AAEILDMESRHISET	AKAP9	2836	Q99996
EMSSTLDRERELHAQ	AKAP9	3311	Q99996
HMYLDEEIRLDTSSE	PRMT9	791	Q6P2P2
EMSAHERSLDFLIEL	DCTN1	691	Q14203
TEDSDFLMSLDLESR	FBXO10	286	Q9UK96
ASLELSAESRMILDA	BEND4	156	Q6ZU67
LSEEDLESDQREHRM	AKAP13	1646	Q12802
DILLDMLSESTAESH	CBY1	96	Q9Y3M2
HDSELEQSRILMDDL	AFG1L	421	Q8WV93
SLSRMELDESSLQEL	APBA3	46	O96018
MESDFALLTLSDHEQ	CAMTA2	1031	O94983
EERTTIHEMFLSTLD	ACOT9	256	Q9Y305
LDTAETLEMELSNSH	AMER1	896	Q5JTC6
TDEMLTHSITLRLED	CELSR2	1121	Q9HCU4
EISEVLDSLENLMRH	DMD	1301	P11532
TEDLFLNMEHESLTL	ANKRD12	706	Q6UB98
SDLHLILMSATVDSE	DHX29	726	Q7Z478
SDEVLSEFELRLLSM	BMP2	46	P12643
FLMSDRSLHLEASLD	ARRB2	191	P32121
VEMLTRASSDLLSDL	C1orf87	381	Q8N0U7
DLTASHDAALLEMEN	MTUS2	1136	Q5JR59
MLADESDHETLTAIL	RAG1	661	P15918
ATREHLLMALADLDE	HSPG2	1476	P98160
LELMLHEVLEEEATS	RIC1	861	Q4ADV7
DSMIHDILDRIATEA	H2BW2	86	P0C1H6
MDSLVHDILDRIATE	H2BW1	106	Q7Z2G1
IMESRHDSENAERIL	ITPR2	2051	Q14571
HQSLDDALRDLSAAM	ARHGEF17	1401	Q96PE2
DALRDLSAAMHRDLS	ARHGEF17	1406	Q96PE2
LEAEETRHNRSMSEL	FBXO42	36	Q6P3S6
LLDENEDMHSLLLTD	PAN2	151	Q504Q3
EDMHSLLLTDSSTLL	PAN2	156	Q504Q3
FSEILLRASEHLEMI	MAGEB16	151	A2A368
TERHLMHLELDISDS	POR	296	P16435
SKLLLAIMESRHDSE	ITPR1	2101	Q14643
TMESLRELHIFDNDL	NLRP11	631	P59045
LEHDLSLGTLAMETV	GMIP	156	Q9P107
SELHMTTARREEELQ	MMRN2	381	Q9H8L6
SVLTDLLDAMHTLRE	JMJD1C	1911	Q15652
LRALDTLEDDMTISV	FDFT1	76	P37268
LYHMRLSDETLLEIS	HK2	26	P52789
NREDEHLRSTIELSM	ATXN3L	241	Q9H3M9
EMLSDHSIRSFDDLQ	PDGFB	31	P01127
RLTMFILDDHDSDLD	PDPR	766	Q8NCN5
LDRLLSTALMEDAEI	EFR3B	456	Q9Y2G0
RMTENLLASLSEHER	NPRL3	481	Q12980
SSLLSAILEEMHLLE	ABCC11	551	Q96J66
SMILEDLESALAEHA	NRF1	161	Q16656
SMDLHELESIVEDAT	NEK11	446	Q8NG66
TLRAELLMSLHDLDV	NELFB	236	Q8WX92
VMASDHREALLDRES	LRRC45	606	Q96CN5
HSMRDALESTLAETE	KRT35	331	Q92764
ELLVAVHMLRDSASD	EPHA10	671	Q5JZY3
HLEIDAAMLTSTADT	PAPPA	861	Q13219
AVMSLLHTLEELKSD	PCNT	3011	O95613
HILDDISTMFDALAD	CASKIN2	1181	Q8WXE0
LHRSSTEIDDMLRKS	EXOC6	506	Q8TAG9
LVSIVDSLHLEMEEA	MYBBP1A	456	Q9BQG0
ADVDSELAAMLLTHA	NPHP4	881	O75161
LSDATMLIHSSEEEE	PTPN21	701	Q16825
MDDLDALLADLESTT	PXN	1	P49023
SATRELDELMASLSD	PXN	261	P49023
LDASMHSQLRILDEE	ABCC5	61	O15440
HFDLLDLTELTDMSD	DBNDD1	71	Q9H9R9
LDMIDHTSIRTIEEL	C3orf62	176	Q6ZUJ4
SELSEQVLETLHDAM	COL6A3	1806	P12111
NDIDSMSLTTDDLLR	LAS2	116	Q8IYD9
IDLLARLSIHMDDEL	FRY	626	Q5TBA9
MDSHVLSLIASEERE	C4orf54	1286	D6RIA3
RMHCDDETSLLLASL	PTPN13	691	Q12923
LDLSDSSVTRDMDIL	NTMT2	231	Q5VVY1
HMYEEAVRELESLLS	FAN1	681	Q9Y2M0
MLSDSHGVETIRDIL	PLEKHM1	721	Q9Y4G2
RIHDLEDDLEMSSDA	GTF2F1	206	P35269
ITDAQLEAMTELHDR	SLK	401	Q9H2G2
DSSSLLMHRFEREDV	SNAP47	286	Q5SQN1
EDTMETHLETELDLS	LRRTM3	551	Q86VH5
ALEDLHMVVDEDSRS	NCKAP5	156	O14513
AMLVDIEDLTRHAES	SCHIP1	461	P0DPB3
MKLTDIRLEALSSAH	NAV2	1916	Q8IVL1
STSHLLILDDSVEME	RPN1	301	P04843
SDFMEELLTLHSSEA	SPATA31D4	371	Q6ZUB0
MAIDTLLISDELFRH	PELO	306	Q9BRX2
AAHTREMLDTVLEAL	SPTLC3	506	Q9NUV7
MRRDLEEATLQHEAT	MYH6	1176	P13533
FLSDLRDMLDSHLEN	NIF3L1	346	Q9GZT8
LEELSRIMHDEVSET	RASGRF1	416	Q13972
DDLHSQMLSSTAILD	MRTFA	841	Q969V6
ERILASASHEMDRIS	AKAP6	1526	Q13023
SEDLLMDLTNHVLSE	CIB4	136	A0PJX0
LQTHSSLFLEELEML	PITPNM1	776	O00562
HIDDLRRSTLMVSDV	RNF213	3441	Q63HN8
MALSLEEFVHSLDLR	THEMIS	1	Q8N1K5
SDFMEELLTLHSSEA	SPATA31D3	371	P0C874
ITLHITDASDMTRDL	ZPR1	311	O75312
DMLELDHLTVSGDVT	UGP2	451	Q16851
SREEIMATLLDHDLS	REV3L	1886	O60673
DELSLIDHNEIMSRL	RAPGEF1	666	Q13905
TTEEDSVLLMHTLLA	TRO	36	Q12816
ATHEDVDTTMLRRAL	SESN3	391	P58005
DLMRDLERSHTACAT	MYH13	1431	Q9UKX3
VLTADLESMHSELEN	MYO18B	1856	Q8IUG5
LEDTLHVVDMEARLT	TTLL9	361	Q3SXZ7
TAMDSLTDLDLEHLL	UBN1	306	Q9NPG3
LMLQLLIHEDDDISS	XPOT	331	O43592
LMEHEQTDITSRDSR	TRPV3	281	Q8NET8
TTDEALMEEARLHVA	SLC9C2	501	Q5TAH2
ISLAMTLKTLDEHRD	SEPSECS	371	Q9HD40
MEDLDALLSDLETTT	TGFB1I1	1	O43294
MLEELEADTARTLTD	TRIM62	196	Q9BVG3
HQLATLLMELDSEDE	TTC34	36	A8MYJ7
LLMELDSEDEASRLL	TTC34	41	A8MYJ7
AMETALAHLESLAVD	PJA2	586	O43164
SSLAELMARTSLDLE	WWC3	956	Q9ULE0
ALSSLIHALDDLDMV	XRCC5	376	P13010
ALLDSDEERMITHFE	TMEM87A	536	Q8NBN3