Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	calmodulin-dependent protein phosphatase activity	PPP3CA PPP3CB PPM1F	6.87e-06	5	178	3	GO:0033192
GeneOntologyMolecularFunction	calcium-dependent protein serine/threonine phosphatase activity	PPP3CA PPP3CB PPM1F	3.77e-05	8	178	3	GO:0004723
GeneOntologyMolecularFunction	temperature-gated cation channel activity	TRPA1 KCNK4	7.90e-05	2	178	2	GO:0097604
GeneOntologyMolecularFunction	amino acid sensor activity	SAR1A SAR1B	7.90e-05	2	178	2	GO:0140785
GeneOntologyMolecularFunction	temperature-gated ion channel activity	TRPA1 KCNK4	2.36e-04	3	178	2	GO:0097603
GeneOntologyMolecularFunction	metal ion transmembrane transporter activity	TRPA1 SLC39A10 KCNK4 RYR1 SLC8A2 SLC34A1 ABCC8 TMEM37 SLC39A14 CHRNA10 SLC23A1 SLC39A7 KCNH5	2.84e-04	465	178	13	GO:0046873
GeneOntologyBiologicalProcess	glucose homeostasis	DMXL2 ANG HK3 TRPA1 CLTRN BGLAP PPP3CA PPP3CB ABCC8 SLC39A14 BAIAP3 SLC37A4 PCK2	5.84e-06	338	173	13	GO:0042593
GeneOntologyBiologicalProcess	carbohydrate homeostasis	DMXL2 ANG HK3 TRPA1 CLTRN BGLAP PPP3CA PPP3CB ABCC8 SLC39A14 BAIAP3 SLC37A4 PCK2	6.03e-06	339	173	13	GO:0033500
GeneOntologyBiologicalProcess	intracellular glucose homeostasis	ANG HK3 TRPA1 CLTRN PPP3CA PPP3CB ABCC8 SLC39A14 BAIAP3 PCK2	1.61e-05	218	173	10	GO:0001678
GeneOntologyBiologicalProcess	organic acid metabolic process	EPHX1 HK3 ASPG MTHFD1L UGT1A5 ACSS1 DDO CPS1 PLA2G4D GGT7 LDHD CYP2R1 SLC34A1 SGPL1 LPL TLR4 ERRFI1 MCAT HADHA SARDH SLC23A1 SLC37A4 PCK2	2.95e-05	1064	173	23	GO:0006082
GeneOntologyBiologicalProcess	response to xenobiotic stimulus	EPHX1 TRPA1 MYLK HMBS GPR52 CPS1 BGLAP ABCB1 CYP2R1 SLC34A1 PPM1F ABCC8 ARNT2 ERRFI1 HADHA	3.81e-05	525	173	15	GO:0009410
GeneOntologyBiologicalProcess	cellular response to glucose stimulus	ANG TRPA1 CLTRN PPP3CA PPP3CB ABCC8 SLC39A14 BAIAP3 PCK2	4.26e-05	196	173	9	GO:0071333
GeneOntologyBiologicalProcess	chemical homeostasis	DMXL2 ANG HK3 TRPA1 CLTRN TCIRG1 SLC39A10 CPS1 RYR1 BGLAP SLC8A2 PPP3CA PPP3CB SLC34A1 ABCC8 LPL SAR1B ERRFI1 FCRL5 SLC39A14 BAIAP3 SLC37A4 PCK2 SLC39A7 WDR72	4.60e-05	1249	173	25	GO:0048878
GeneOntologyBiologicalProcess	cellular response to hexose stimulus	ANG TRPA1 CLTRN PPP3CA PPP3CB ABCC8 SLC39A14 BAIAP3 PCK2	4.80e-05	199	173	9	GO:0071331
GeneOntologyBiologicalProcess	cellular response to monosaccharide stimulus	ANG TRPA1 CLTRN PPP3CA PPP3CB ABCC8 SLC39A14 BAIAP3 PCK2	5.18e-05	201	173	9	GO:0071326
GeneOntologyBiologicalProcess	carboxylic acid metabolic process	EPHX1 HK3 ASPG MTHFD1L UGT1A5 ACSS1 DDO CPS1 PLA2G4D GGT7 LDHD SLC34A1 SGPL1 LPL TLR4 ERRFI1 MCAT HADHA SARDH SLC23A1 SLC37A4 PCK2	5.72e-05	1035	173	22	GO:0019752
GeneOntologyBiologicalProcess	response to glucose	ANG TRPA1 CLTRN PPP3CA PPP3CB ABCC8 LPL SLC39A14 BAIAP3 PCK2	7.16e-05	260	173	10	GO:0009749
GeneOntologyBiologicalProcess	regulation of protein transport	ANG TRPA1 LYPLAL1 TCIRG1 SAR1A BGLAP PPP3CA PPP3CB UBR5 PPM1F ABCC8 SAR1B TLR4 BAIAP3 PCK2	7.89e-05	560	173	15	GO:0051223
GeneOntologyBiologicalProcess	oxoacid metabolic process	EPHX1 HK3 ASPG MTHFD1L UGT1A5 ACSS1 DDO CPS1 PLA2G4D GGT7 LDHD SLC34A1 SGPL1 LPL TLR4 ERRFI1 MCAT HADHA SARDH SLC23A1 SLC37A4 PCK2	7.90e-05	1058	173	22	GO:0043436
GeneOntologyBiologicalProcess	positive regulation of protein transport	ANG TRPA1 SAR1A BGLAP PPP3CB UBR5 ABCC8 SAR1B TLR4 BAIAP3 PCK2	8.31e-05	319	173	11	GO:0051222
GeneOntologyBiologicalProcess	response to hexose	ANG TRPA1 CLTRN PPP3CA PPP3CB ABCC8 LPL SLC39A14 BAIAP3 PCK2	8.39e-05	265	173	10	GO:0009746
GeneOntologyBiologicalProcess	cellular response to carbohydrate stimulus	ANG TRPA1 CLTRN PPP3CA PPP3CB ABCC8 SLC39A14 BAIAP3 PCK2	8.70e-05	215	173	9	GO:0071322
GeneOntologyBiologicalProcess	metal ion transport	TRPA1 MYLK SLC39A10 KCNK4 RYR1 JAK3 SLC8A2 FCRL3 PPP3CA PPP3CB SLC34A1 ABCC8 SLC22A5 TMEM37 FCRL5 SLC39A14 CHRNA10 RNF207 SLC23A1 SLC39A7 KCNH5	1.01e-04	1000	173	21	GO:0030001
GeneOntologyBiologicalProcess	response to monosaccharide	ANG TRPA1 CLTRN PPP3CA PPP3CB ABCC8 LPL SLC39A14 BAIAP3 PCK2	1.04e-04	272	173	10	GO:0034284
GeneOntologyBiologicalProcess	intracellular chemical homeostasis	DMXL2 ANG HK3 TRPA1 CLTRN TCIRG1 SLC39A10 RYR1 SLC8A2 PPP3CA PPP3CB SLC34A1 ABCC8 FCRL5 SLC39A14 BAIAP3 SLC37A4 PCK2 SLC39A7	1.26e-04	866	173	19	GO:0055082
GeneOntologyBiologicalProcess	inorganic cation import across plasma membrane	SLC39A10 SLC8A2 PPP3CA PPP3CB SLC34A1 ABCC8 SLC39A14	1.99e-04	142	173	7	GO:0098659
GeneOntologyBiologicalProcess	inorganic ion import across plasma membrane	SLC39A10 SLC8A2 PPP3CA PPP3CB SLC34A1 ABCC8 SLC39A14	1.99e-04	142	173	7	GO:0099587
GeneOntologyBiologicalProcess	response to carbohydrate	ANG TRPA1 CLTRN PPP3CA PPP3CB ABCC8 LPL SLC39A14 BAIAP3 PCK2	2.37e-04	301	173	10	GO:0009743
GeneOntologyBiologicalProcess	positive regulation of protein secretion	ANG TRPA1 BGLAP PPP3CB ABCC8 TLR4 BAIAP3 PCK2	2.39e-04	194	173	8	GO:0050714
GeneOntologyBiologicalProcess	monoatomic cation transport	TRPA1 MYLK TCIRG1 SLC39A10 KCNK4 RYR1 JAK3 SLC8A2 FCRL3 PPP3CA PPP3CB SLC34A1 ABCC8 SLC22A5 TMEM37 FCRL5 SLC39A14 CHRNA10 RNF207 SLC23A1 SLC39A7 KCNH5	2.81e-04	1157	173	22	GO:0006812
GeneOntologyBiologicalProcess	inorganic ion transmembrane transport	TRPA1 TCIRG1 SLC39A10 SLC26A1 KCNK4 RYR1 SLC8A2 PPP3CA PPP3CB SLC34A1 ABCC8 TMEM37 FCRL5 SLC39A14 CHRNA10 RNF207 SLC23A1 SLC37A4 SLC39A7 KCNH5	3.53e-04	1017	173	20	GO:0098660
MousePheno	abnormal spleen periarteriolar lymphoid sheath morphology	TCIRG1 JAK3 SGPL1 IL2RB	7.50e-06	14	134	4	MP:0002358
Domain	-	ANKRD31 CDKN2B TRPA1 ASPG ASB14 ANKRD27 ASB10 ANKIB1 ANKRD28 TNKS NOTCH2	2.29e-05	248	175	11	1.25.40.20
Domain	ANK	ANKRD31 CDKN2B TRPA1 ASPG ASB14 ANKRD27 ASB10 ANKIB1 ANKRD28 TNKS NOTCH2	2.56e-05	251	175	11	SM00248
Domain	ANK_REPEAT	ANKRD31 CDKN2B TRPA1 ASPG ASB14 ANKRD27 ASB10 ANKIB1 ANKRD28 TNKS NOTCH2	2.75e-05	253	175	11	PS50088
Domain	Ankyrin_rpt-contain_dom	ANKRD31 CDKN2B TRPA1 ASPG ASB14 ANKRD27 ASB10 ANKIB1 ANKRD28 TNKS NOTCH2	2.86e-05	254	175	11	IPR020683
Domain	ANK_REP_REGION	ANKRD31 CDKN2B TRPA1 ASPG ASB14 ANKRD27 ASB10 ANKIB1 ANKRD28 TNKS NOTCH2	2.86e-05	254	175	11	PS50297
Domain	Ankyrin_rpt	ANKRD31 CDKN2B TRPA1 ASPG ASB14 ANKRD27 ASB10 ANKIB1 ANKRD28 TNKS NOTCH2	3.79e-05	262	175	11	IPR002110
Domain	Ank	ANKRD31 CDKN2B TRPA1 ASB14 ANKRD27 ASB10 ANKIB1 ANKRD28 TNKS NOTCH2	5.96e-05	228	175	10	PF00023
Domain	SAR1	SAR1A SAR1B	8.73e-05	2	175	2	PS51422
Domain	Small_GTPase_SAR1	SAR1A SAR1B	8.73e-05	2	175	2	IPR006687
Domain	DUF4599	SPATA31A3 SPATA31A7 SPATA31A5	1.67e-04	12	175	3	PF15371
Domain	DUF4599	SPATA31A3 SPATA31A7 SPATA31A5	1.67e-04	12	175	3	IPR027970
Domain	Ank_2	ANKRD31 TRPA1 ASPG ASB14 ANKRD27 ASB10 ANKRD28 TNKS NOTCH2	1.99e-04	215	175	9	PF12796
Domain	ZIP	SLC39A10 SLC39A14 SLC39A7	2.73e-04	14	175	3	IPR003689
Domain	Zip	SLC39A10 SLC39A14 SLC39A7	2.73e-04	14	175	3	PF02535
Domain	DH_1	OBSCN PLEKHG2 ARHGEF15 ARHGEF40 ARHGEF2	3.09e-04	63	175	5	PS00741
Domain	RhoGEF	OBSCN PLEKHG2 ARHGEF15 ARHGEF40 ARHGEF2	5.05e-04	70	175	5	PF00621
Domain	DH_2	OBSCN PLEKHG2 ARHGEF15 ARHGEF40 ARHGEF2	5.05e-04	70	175	5	PS50010
Domain	-	OBSCN PLEKHG2 ARHGEF15 ARHGEF40 ARHGEF2	5.39e-04	71	175	5	1.20.900.10
Domain	DH-domain	OBSCN PLEKHG2 ARHGEF15 ARHGEF40 ARHGEF2	5.39e-04	71	175	5	IPR000219
Pathway	REACTOME_BIOLOGICAL_OXIDATIONS	EPHX1 MAT2B UGT1A5 ACSS1 PODXL2 SLC26A1 GGT7 PAOX CYP2R1 ARNT2 OPLAH	4.21e-06	219	126	11	MM14838
Pathway	REACTOME_BIOLOGICAL_OXIDATIONS	EPHX1 MAT2B UGT1A5 ACSS1 PODXL2 SLC26A1 GGT7 PAOX CYP2R1 ARNT2 OPLAH	4.40e-06	220	126	11	M10320
Pathway	REACTOME_ZINC_INFLUX_INTO_CELLS_BY_THE_SLC39_GENE_FAMILY	SLC39A10 SLC39A14 SLC39A7	7.99e-05	10	126	3	M27361
Pubmed	The testis-specific VAD1.3/AEP1 interacts with β-actin and syntaxin 1 and directs peri-nuclear/Golgi expression with bipartite nucleus localization (BNL) sequence.	SPATA31A3 SPATA31A7 SPATA31A5 SPATA31A1	1.01e-08	6	179	4	20850414
Pubmed	Targeted disruption of the spermatid-specific gene Spata31 causes male infertility.	SPATA31A3 SPATA31A7 SPATA31A5 SPATA31A1	1.01e-08	6	179	4	25930072
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	TUT4 CENPB BICRA POLR2A PRSS56 LGR4 RNF213 CLSTN2 ZNF318 NSD3 ARHGEF40 TRMT2A EML5 UBR5 SGPL1 MTIF2 MORF4L1 XRN1 ANKRD28 CLSPN SLC39A7 NOTCH2 WDR72	1.75e-08	1116	179	23	31753913
Pubmed	Majority of cerebrospinal fluid-contacting neurons in the spinal cord of C57Bl/6N mice is present in ectopic position unlike in other studied experimental mice strains and mammalian species.	SPATA31A3 SPATA31A7 SPATA31A5 CYFIP2 SPATA31A1	1.34e-07	24	179	5	32212159
Pubmed	Cytoplasmic Metadherin (MTDH) provides survival advantage under conditions of stress by acting as RNA-binding protein.	TBC1D2B OBSCN TCIRG1 RNF213 NEB RYR1 CYFIP2 ARNT2 IL2RB ANKRD26P1	1.84e-07	214	179	10	22199357
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	DMXL2 ANKRD27 URGCP SBNO2 ARHGEF40 TRMT2A SGPL1 MTIF2 LPL XRN1 MARF1 ANKIB1 ANKRD28 ARHGEF2 CLSPN CMTR2	2.95e-07	650	179	16	38777146
Pubmed	BCAR1 promotes proliferation and cell growth in lung adenocarcinoma via upregulation of POLR2A.	EPHX1 POLR2A FBXL7 PPP3CB TRMT2A AP2A2 UBR5 SLC34A1 SUPT6H SAR1B ARHGEF2 NLRC3 PCK2	3.06e-07	419	179	13	33001583
Pubmed	Exome sequencing in seven families and gene-based association studies indicate genetic heterogeneity and suggest possible candidates for fibromuscular dysplasia.	MYLK OBSCN RNF213	5.34e-07	4	179	3	26147384
Pubmed	Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity.	RAG1 NLRP3 TLR4 TLR5	1.53e-06	17	179	4	22297845
Pubmed	Regulation of Legionella phagosome maturation and infection through flagellin and host Ipaf.	NLRP3 TLR4 TLR5	2.65e-06	6	179	3	16984919
Pubmed	Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV.	DDR1 MTHFD1L BICRA CLTRN KIAA0232 LGR4 TCIRG1 RNF213 GGT7 MROH1 TAMM41 SLC22A5 ANKIB1 MICA SLC39A14 ARHGEF2 SLC37A4 NOTCH2 WDR72	2.67e-06	1061	179	19	33845483
Pubmed	Genetic polymorphisms associated with inflammatory bowel disease do not confer risk for primary sclerosing cholangitis.	ABCB1 SLC22A5 TLR4	4.62e-06	7	179	3	17100974
Pubmed	The gene for soluble N-ethylmaleimide sensitive factor attachment protein alpha is mutated in hydrocephaly with hop gait (hyh) mice.	BICRA KPTN SLC8A2	7.37e-06	8	179	3	14755058
Pubmed	Association of IL23R, TNFRSF1A, and HLA-DRB1*0103 allele variants with inflammatory bowel disease phenotypes in the Finnish population.	ABCB1 SLC22A5 TLR4	1.10e-05	9	179	3	18338763
Pubmed	MyD88 is critically involved in immune tolerance breakdown at environmental interfaces of Foxp3-deficient mice.	RAG1 TLR4 TLR5	1.10e-05	9	179	3	22466646
Pubmed	Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling.	CENPB LYPLAL1 MTHFD1L RPS11 LGR4 NSD3 ARHGEF40 PPP3CA TAMM41 UBR5 MORF4L1 LPL SAR1B PTRH1 MICA HADHA SLC39A14 DDX39A SLC39A7 NOTCH2	1.31e-05	1297	179	20	33545068
Pubmed	Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.	RPS11 LGR4 RNF213 PODXL2 ZNF318 SLC39A10 SAR1A PPP3CA UBR5 SAR1B XRN1 ANKRD28 SLC39A14 CLSPN NOTCH2	1.33e-05	777	179	15	35844135
Pubmed	Airway uric acid is a sensor of inhaled protease allergens and initiates type 2 immune responses in respiratory mucosa.	RAG1 NLRP3 TLR4	1.57e-05	10	179	3	24663677
Pubmed	TNF is required for TLR ligand-mediated but not protease-mediated allergic airway inflammation.	RAG1 TLR4 TLR5	1.57e-05	10	179	3	28758900
Pubmed	Interleukin-2 critically regulates bone marrow erythropoiesis and prevents anemia development.	RAG1 JAK3 IL2RB	1.57e-05	10	179	3	26404745
Pubmed	Downregulation of the Na/K-ATPase pump by leptospiral glycolipoprotein activates the NLRP3 inflammasome.	NLRP3 TLR4 TLR5	1.57e-05	10	179	3	22323544
Pubmed	Sequential ubiquitination of NLRP3 by RNF125 and Cbl-b limits inflammasome activation and endotoxemia.	RAG1 RNF213 NLRP3	2.15e-05	11	179	3	31999304
Pubmed	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.	DMXL2 KIAA0232 ARHGEF15 FBXL7 AP2A2 UBR5 ANKRD28 BAIAP3	2.34e-05	225	179	8	12168954
Pubmed	Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.	HK3 OXR1 MAT2B MTHFD1L ACSS1 TCIRG1 GLOD4 CPS1 LDHD TAMM41 MTIF2 PTRH1 MCAT HADHA SARDH PCK2	2.63e-05	926	179	16	20877624
Pubmed	Constitutively active calcineurin in skeletal muscle increases endurance performance and mitochondrial respiratory capacity.	PPP3CA PPP3CB	2.63e-05	2	179	2	19861587
Pubmed	Inhibition of calcineurin phosphatase promotes exocytosis of renin from juxtaglomerular cells.	PPP3CA PPP3CB	2.63e-05	2	179	2	19907416
Pubmed	Toll-like receptors 4 and 5 induce distinct types of vasculitis.	TLR4 TLR5	2.63e-05	2	179	2	19150884
Pubmed	Dephosphorylation of the small heat shock protein hsp25 by calcium/calmodulin-dependent (type 2B) protein phosphatase.	PPP3CA PPP3CB	2.63e-05	2	179	2	1328240
Pubmed	Functional overlap between the mammalian Sar1a and Sar1b paralogs in vivo.	SAR1A SAR1B	2.63e-05	2	179	2	38687799
Pubmed	Decreased expression of Toll-like receptor 4 and 5 during progression of prostate transformation in transgenic adenocarcinoma of mouse prostate mice.	TLR4 TLR5	2.63e-05	2	179	2	25797291
Pubmed	Toll-like Receptors 4 and 5 Cooperatively Initiate the Innate Immune Responses to Uropathogenic Escherichia coli Infection in Mouse Epididymal Epithelial Cells.	TLR4 TLR5	2.63e-05	2	179	2	26819479
Pubmed	Silencing of mammalian Sar1 isoforms reveals COPII-independent protein sorting and transport.	SAR1A SAR1B	2.63e-05	2	179	2	23433038
Pubmed	Modulation of membrane rigidity by the human vesicle trafficking proteins Sar1A and Sar1B.	SAR1A SAR1B	2.63e-05	2	179	2	22974979
Pubmed	Cloning of human calcineurin A: evidence for two isozymes and identification of a polyproline structural domain.	PPP3CA PPP3CB	2.63e-05	2	179	2	2556704
Pubmed	Association of TLR4 and TLR5 gene polymorphisms with Graves' disease in Chinese Cantonese population.	TLR4 TLR5	2.63e-05	2	179	2	24830583
Pubmed	Lactoferrin Retargets Human Adenoviruses to TLR4 to Induce an Abortive NLRP3-Associated Pyroptotic Response in Human Phagocytes.	NLRP3 TLR4	2.63e-05	2	179	2	34093588
Pubmed	Toll-like receptor 4-interacting SPA4 peptide suppresses the NLRP3 inflammasome in response to LPS and ATP stimuli.	NLRP3 TLR4	2.63e-05	2	179	2	26254306
Pubmed	Ethanol-Induced TLR4/NLRP3 Neuroinflammatory Response in Microglial Cells Promotes Leukocyte Infiltration Across the BBB.	NLRP3 TLR4	2.63e-05	2	179	2	26555554
Pubmed	Alpinetin attenuates inflammatory responses by suppressing TLR4 and NLRP3 signaling pathways in DSS-induced acute colitis.	NLRP3 TLR4	2.63e-05	2	179	2	27321991
Pubmed	Activation of NLRP3 inflammasome by lymphocytic microparticles via TLR4 pathway contributes to airway inflammation.	NLRP3 TLR4	2.63e-05	2	179	2	31759058
Pubmed	Toll-like receptor triggering in cord blood mesenchymal stem cells.	TLR4 TLR5	2.63e-05	2	179	2	20196781
Pubmed	Genetic risk of FCRL3 and FCRL5 polymorphisms in children with asthma and allergic rhinitis in a Chinese Han population.	FCRL3 FCRL5	2.63e-05	2	179	2	30771554
Pubmed	Lipopolysaccharide-Induced TRPA1 Upregulation in Trigeminal Neurons is Dependent on TLR4 and Vesicular Exocytosis.	TRPA1 TLR4	2.63e-05	2	179	2	37643860
Pubmed	Lethal multiple pterygium syndrome, large cystic hygroma, and cleft palate: Rare and severe fetal presentations of RYR1- and NEB-related congenital myopathies.	NEB RYR1	2.63e-05	2	179	2	38520674
Pubmed	MICA and NLRP3 gene polymorphisms interact synergistically affecting the risk of ankylosing spondylitis.	NLRP3 MICA	2.63e-05	2	179	2	37665559
Pubmed	Molecular analysis of SAR1-related cDNAs from a mouse pituitary cell line.	SAR1A SAR1B	2.63e-05	2	179	2	8262187
Pubmed	Oxidation-induced conformational changes in calcineurin determined by covalent labeling and tandem mass spectrometry.	PPP3CA PPP3CB	2.63e-05	2	179	2	25286016
Pubmed	Hyperin protects against LPS-induced acute kidney injury by inhibiting TLR4 and NLRP3 signaling pathways.	NLRP3 TLR4	2.63e-05	2	179	2	27813491
Pubmed	Toll-like receptors TLR4, TLR5 and TLR9 on gastric carcinoma cells: an implication for interaction with Helicobacter pylori.	TLR4 TLR5	2.63e-05	2	179	2	16044857
Pubmed	Involvement of Toll-like receptor 5 in the recognition of flagellated bacteria.	TLR4 TLR5	2.63e-05	2	179	2	16891416
Pubmed	Detection of pathogenic intestinal bacteria by Toll-like receptor 5 on intestinal CD11c+ lamina propria cells.	TLR4 TLR5	2.63e-05	2	179	2	16829963
Pubmed	Chromosomal assignments of the genes for the calcineurin A alpha (Calna1) and A beta subunits (Calna2) in the rat.	PPP3CA PPP3CB	2.63e-05	2	179	2	8187553
Pubmed	Anti-dsDNA antibodies bind to TLR4 and activate NLRP3 inflammasome in lupus monocytes/macrophages.	NLRP3 TLR4	2.63e-05	2	179	2	27250627
Pubmed	Estrogen-inducible sFRP5 inhibits early B-lymphopoiesis in vivo, but not during pregnancy.	RAG1 SFRP5	2.63e-05	2	179	2	25676235
Pubmed	Osteoclasts promote the formation of hematopoietic stem cell niches in the bone marrow.	TCIRG1 BGLAP	2.63e-05	2	179	2	22351931
Pubmed	Genetic conservation of the immunophilin-binding domains of human calcineurin A1 and A2.	PPP3CA PPP3CB	2.63e-05	2	179	2	11005320
Pubmed	The GM-CSF Released by Airway Epithelial Cells Orchestrates the Mucosal Adjuvant Activity of Flagellin.	TLR4 TLR5	2.63e-05	2	179	2	33008952
Pubmed	The endoplasmic reticulum coat protein II transport machinery coordinates cellular lipid secretion and cholesterol biosynthesis.	SAR1A SAR1B	2.63e-05	2	179	2	24338480
Pubmed	Toll-like receptor 4 signaling in T cells promotes autoimmune inflammation.	RAG1 TLR4	2.63e-05	2	179	2	22826216
Pubmed	Porcine Toll-like receptors: the front line of pathogen monitoring and possible implications for disease resistance.	TLR4 TLR5	2.63e-05	2	179	2	18590761
Pubmed	Coexpression of calcineurin A and B subunits in various subcellular and synaptic compartments of cerebellar neurons and glia with particular abundance at parallel fiber-Purkinje cell synapses.	PPP3CA PPP3CB	2.63e-05	2	179	2	35247520
Pubmed	TLR4-dependent upregulation of the platelet NLRP3 inflammasome promotes platelet aggregation in a murine model of hindlimb ischemia.	NLRP3 TLR4	2.63e-05	2	179	2	30522866
Pubmed	Expression and functional analysis of toll-like receptors of peripheral blood cells in asthmatic patients: implication for immunopathological mechanism in asthma.	TLR4 TLR5	2.63e-05	2	179	2	19067129
Pubmed	The role of calcium/calmodulin-activated calcineurin in rapid and slow endocytosis at central synapses.	PPP3CA PPP3CB	2.63e-05	2	179	2	20810903
Pubmed	Abnormal expression of urea cycle enzyme genes in juvenile visceral steatosis (jvs) mice.	CPS1 SLC22A5	2.63e-05	2	179	2	1540663
Pubmed	Whole-blood gene expression profiling in ankylosing spondylitis shows upregulation of toll-like receptor 4 and 5.	TLR4 TLR5	2.63e-05	2	179	2	20952467
Pubmed	Calcineurin A-alpha but not A-beta is required for normal kidney development and function.	PPP3CA PPP3CB	2.63e-05	2	179	2	15509543
Pubmed	A Novel TLR4-Binding Domain of Peroxiredoxin From Entamoeba histolytica Triggers NLRP3 Inflammasome Activation in Macrophages.	NLRP3 TLR4	2.63e-05	2	179	2	34659265
Pubmed	Mycoplasma pneumoniae lipids license TLR-4 for activation of NLRP3 inflammasome and autophagy to evoke a proinflammatory response.	NLRP3 TLR4	2.63e-05	2	179	2	32894580
Pubmed	Physiological expression and function of the MDR1 transporter in cytotoxic T lymphocytes.	RAG1 ABCB1	2.63e-05	2	179	2	32302378
Pubmed	ABCB1 transporter and Toll-like receptor 4 in trabecular meshwork cells.	ABCB1 TLR4	2.63e-05	2	179	2	25802484
Pubmed	Induction of macrophage nitric oxide production by Gram-negative flagellin involves signaling via heteromeric Toll-like receptor 5/Toll-like receptor 4 complexes.	TLR4 TLR5	2.63e-05	2	179	2	12794153
Pubmed	Calcineurin expression and activity is regulated by the intracellular redox status and under hypertension in human neutrophils.	PPP3CA PPP3CB	2.63e-05	2	179	2	22739212
Pubmed	The Innate Immune Sensor NLRC3 Acts as a Rheostat that Fine-Tunes T Cell Responses in Infection and Autoimmunity.	RAG1 NLRC3	2.63e-05	2	179	2	30566882
Pubmed	Are calcineurin genes associated with athletic status? A function, replication study.	PPP3CA PPP3CB	2.63e-05	2	179	2	21233773
Pubmed	Dysregulated myelopoiesis in mice lacking Jak3.	RAG1 JAK3	2.63e-05	2	179	2	10419884
Pubmed	Toll-like receptors -4 and -5 in oral and cutaneous squamous cell carcinomas.	TLR4 TLR5	2.63e-05	2	179	2	25047824
Pubmed	SAR1B senses leucine levels to regulate mTORC1 signalling.	SAR1A SAR1B	2.63e-05	2	179	2	34290409
Pubmed	Extracellular nucleoprotein exacerbates influenza virus pathogenesis by activating Toll-like receptor 4 and the NLRP3 inflammasome.	NLRP3 TLR4	2.63e-05	2	179	2	35459853
Pubmed	Compensatory renal hypertrophy following uninephrectomy is calcineurin-independent.	PPP3CA PPP3CB	2.63e-05	2	179	2	25287476
Pubmed	Gene Expression Profiling of Toll-Like Receptor 4 and 5 in Peripheral Blood Mononuclear Cells in Rheumatic Disorders: Ankylosing Spondylitis and Rheumatoid Arthritis.	TLR4 TLR5	2.63e-05	2	179	2	26996117
Pubmed	The Nlrp3 Inflammasome Suppresses Colorectal Cancer Metastatic Growth in the Liver by Promoting Natural Killer Cell Tumoricidal Activity.	RAG1 NLRP3 JAK3	2.85e-05	12	179	3	26384545
Pubmed	MyD88-dependent signaling contributes to host defense against ehrlichial infection.	NLRP3 TLR4 TLR5	2.85e-05	12	179	3	20668698
Pubmed	In vivo IFN-γ secretion by NK cells in response to Salmonella typhimurium requires NLRC4 inflammasomes.	RAG1 NLRP3 TLR4	2.85e-05	12	179	3	24827856
Pubmed	Canonical Inflammasomes Drive IFN-γ to Prime Caspase-11 in Defense against a Cytosol-Invasive Bacterium.	NLRP3 TLR4 NLRC3	4.68e-05	14	179	3	26320999
Pubmed	A sentinel goblet cell guards the colonic crypt by triggering Nlrp6-dependent Muc2 secretion.	RAG1 NLRP3 TLR4	5.83e-05	15	179	3	27339979
Pubmed	Using genetic and clinical factors to predict tacrolimus dose in renal transplant recipients.	ABCB1 PPP3CA PPP3CB	5.83e-05	15	179	3	21047202
Pubmed	A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.	RANBP2 DMXL2 PEG3 OBSCN NEB RYR1 SUPT6H MORF4L1 ANKRD28 TNKS NOTCH2	5.84e-05	497	179	11	23414517
Pubmed	Mechanisms of NLRP3 inflammasome activation and its role in NSAID-induced enteropathy.	NLRP3 TLR4	7.88e-05	3	179	2	26349656
Pubmed	Increased expression of toll-like receptors (TLR) 2, 4 and 5 in gastric dysplasia.	TLR4 TLR5	7.88e-05	3	179	2	21455638
Pubmed	Elf5 is essential for early embryogenesis and mammary gland development during pregnancy and lactation.	RAG1 PRLR	7.88e-05	3	179	2	15650748
Pubmed	Altered skeletal muscle phenotypes in calcineurin Aalpha and Abeta gene-targeted mice.	PPP3CA PPP3CB	7.88e-05	3	179	2	12773574
Pubmed	TLR4-NLRP3-GSDMD-Mediated Pyroptosis Plays an Important Role in Aggravated Liver Injury of CD38-/- Sepsis Mice.	NLRP3 TLR4	7.88e-05	3	179	2	33860064
Pubmed	Cloning and characterization of molecular isoforms of the catalytic subunit of calcineurin using nonisotopic methods.	PPP3CA PPP3CB	7.88e-05	3	179	2	2162844
Pubmed	Association of SRC-related kinase Lyn with the interleukin-2 receptor and its role in maintaining constitutive phosphorylation of JAK/STAT in human T-cell leukemia virus type 1-transformed T cells.	JAK3 IL2RB	7.88e-05	3	179	2	21345943
Pubmed	Molecular cloning of a full-length cDNA encoding the catalytic subunit of human calmodulin-dependent protein phosphatase (calcineurin A alpha).	PPP3CA PPP3CB	7.88e-05	3	179	2	8392375
Pubmed	Involvement of TLR4 and PPAR-α Receptors in Host Response and NLRP3 Inflammasome Activation, Against Pulmonary Infection With Pseudomonas Aeruginosa.	NLRP3 TLR4	7.88e-05	3	179	2	29547450
Pubmed	Activation of enteroendocrine cells via TLRs induces hormone, chemokine, and defensin secretion.	TLR4 TLR5	7.88e-05	3	179	2	17371986
Pubmed	Regulation of neonatal IgA production by the maternal microbiota.	RAG1 TLR5	7.88e-05	3	179	2	33619092
Pubmed	Identification of functional prolactin (PRL) receptor gene expression: PRL inhibits lipoprotein lipase activity in human white adipose tissue.	LPL PRLR	7.88e-05	3	179	2	12679477
Interaction	CNPY4 interactions	CNPY4 LGR4 ISLR TLR4 LRRTM2	1.64e-06	24	173	5	int:CNPY4
Interaction	LYSMD4 interactions	SAR1A SAR1B DDX39A	1.22e-05	6	173	3	int:LYSMD4
GeneFamily	Ankyrin repeat domain containing	ANKRD31 TRPA1 ASPG ASB14 ANKRD27 ASB10 ANKIB1 ANKRD28 TNKS NOTCH2	2.85e-06	242	113	10	403
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	OBSCN PLEKHG2 ARHGEF15 ARHGEF40 ARHGEF2	5.75e-05	66	113	5	722
GeneFamily	Solute carriers	SLC39A10 SLC26A1 SLC8A2 SLC34A1 SLC22A5 SLC39A14 SLC23A1 SLC37A4 SLC39A7	8.37e-04	395	113	9	752
GeneFamily	CD molecules\|Toll like receptors	TLR4 TLR5	1.69e-03	10	113	2	948
ToppCell	droplet-Pancreas-Endocrine-21m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KIAA0232 PEG3 NEB CYFIP2 EML5 MROH1 PRSS53 ABCC8 BAIAP3 PRLR SLC39A7	4.02e-10	193	179	11	471e65f02937bc18d7c5facdacdf1df58cf0f839
ToppCell	droplet-Pancreas-Endocrine-21m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KIAA0232 PEG3 NEB CYFIP2 EML5 MROH1 PRSS53 ABCC8 BAIAP3 PRLR SLC39A7	4.02e-10	193	179	11	fe451b3295d77b2bd1ac25cf29310c85835a45fe
ToppCell	droplet-Pancreas-Endocrine-21m-Epithelial\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CLTRN PEG3 NEB CYFIP2 EML5 PRSS53 ABCC8 BAIAP3 PRLR SLC39A7	6.75e-09	194	179	10	0b023de48ed8a550d169bbe954881eb04bf4f981
ToppCell	droplet-Pancreas-Endocrine-21m-Epithelial-nan\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CES5A CLTRN PEG3 NEB EML5 PRSS53 ABCC8 BAIAP3 PRLR	2.66e-08	167	179	9	b94e8ee8c3fcebedd8fcd719eadddc04c7513c50
ToppCell	droplet-Lung-nan-21m-Lymphocytic-Plasma_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MUC5B OGFOD3 ABCB1 MGAT1 NACC2 CHRNA10 SLC23A1 PRLR PCK2	3.79e-08	174	179	9	3f4277763e312b46ebd4401ea4a2f5d4c850c768
ToppCell	droplet-Lung-nan-21m-Lymphocytic-plasma_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MUC5B OGFOD3 ABCB1 MGAT1 NACC2 CHRNA10 SLC23A1 PRLR PCK2	3.79e-08	174	179	9	fad66d1a8407574b6a835e0bdb824a53afa58650
ToppCell	droplet-Kidney-nan-18m\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CLTRN ACSS1 LGR4 SLC34A1 LPL SLC22A5 ERRFI1 SARDH PRLR	6.14e-08	184	179	9	e02859bbac36dbbd55d7ae8cb5e46b764d7c6381
ToppCell	droplet-Kidney-nan-18m-Epithelial\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CLTRN ACSS1 LGR4 SLC34A1 LPL SLC22A5 ERRFI1 SARDH PRLR	7.05e-08	187	179	9	236e9857729670e87eed30fad58f49e1f56e4a85
ToppCell	droplet-Pancreas-Endocrine-21m\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PEG3 NEB CYFIP2 EML5 PRSS53 ABCC8 BAIAP3 PRLR SLC39A7	9.65e-08	194	179	9	3a3ecedcdc7691cf21775818b598208fcb980c29
ToppCell	COVID-19-kidney-PEC\|COVID-19 / Disease (COVID-19 only), tissue and cell type	CNTN4 OXR1 ABCB1 AGBL4 ARNT2 SLC39A14 TMEM178B WDR72	4.15e-07	168	179	8	a086c306be430adf0632ba53e98cd8014d2de330
ToppCell	facs-Kidney-nan-18m-Epithelial-kidney_collecting_duct_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LYPLAL1 CLTRN LGR4 SLC34A1 TMEM37 SARDH SLC37A4 PRLR	7.30e-07	181	179	8	bec7076efe94898213a62db72d171d737949977e
ToppCell	facs-Kidney-nan-18m-Epithelial-kidney_collecting_duct_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LYPLAL1 CLTRN LGR4 SLC34A1 TMEM37 SARDH SLC37A4 PRLR	7.30e-07	181	179	8	cf149b30b814cf87c9e923ef502cadf7fe4a3597
ToppCell	droplet-Kidney-nan-18m-Epithelial-kidney_proximal_convoluted_tubule_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LYPLAL1 CLTRN SLC34A1 SLC22A5 ERRFI1 SARDH SLC37A4 PRLR	8.26e-07	184	179	8	7c256bcfa07c5ff55aad0833e8712b0456b5832b
ToppCell	droplet-Kidney-nan-21m-Epithelial-Epcam____kidney_proximal_convoluted_tubule_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LYPLAL1 CLTRN SLC34A1 SLC22A5 ERRFI1 TMEM37 SARDH PRLR	8.26e-07	184	179	8	3d7dd193a0826cc7a4e454a29236a16c315e5965
ToppCell	droplet-Kidney-nan-21m-Epithelial-kidney_proximal_convoluted_tubule_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LYPLAL1 CLTRN SLC34A1 SLC22A5 ERRFI1 TMEM37 SARDH PRLR	8.26e-07	184	179	8	45577ff91c3b2b303acd97239dde2463ea7a429c
ToppCell	droplet-Kidney-nan-18m-Epithelial-Epcam____kidney_proximal_convoluted_tubule_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LYPLAL1 CLTRN SLC34A1 SLC22A5 ERRFI1 SARDH SLC37A4 PRLR	8.26e-07	184	179	8	c86ed59fed687cdaaf7e9c4418d2e3e2c4111cca
ToppCell	droplet-Kidney-nan-3m-Epithelial-Epcam____kidney_proximal_convoluted_tubule_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CLTRN ACSS1 SLC34A1 SLC22A5 ERRFI1 SARDH SLC37A4 PRLR	8.61e-07	185	179	8	3e3217c99719fd1d2fa94e16be7712a7e5077152
ToppCell	droplet-Kidney-nan-3m-Epithelial-kidney_proximal_convoluted_tubule_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CLTRN ACSS1 SLC34A1 SLC22A5 ERRFI1 SARDH SLC37A4 PRLR	8.61e-07	185	179	8	0ff4148b4701003d9d594e0da8261176fb13aa59
ToppCell	facs-Heart-LA/RA-3m-Mesenchymal\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SFRP5 ACSS1 OBSCN DDO ASB14 ABCC8 CHRNA10 RNF207	9.71e-07	188	179	8	90dc0e15798d0b984518ad58c7e416e30aff687a
ToppCell	facs-Heart-LA/RA-3m-Mesenchymal-atrial_myocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SFRP5 ACSS1 OBSCN DDO ASB14 ABCC8 CHRNA10 RNF207	9.71e-07	188	179	8	f63dfd076ced81013918363282ae25cbbd8948ae
ToppCell	facs-Heart-LA/RA-3m-Mesenchymal-atrial_cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SFRP5 ACSS1 OBSCN DDO ASB14 ABCC8 CHRNA10 RNF207	9.71e-07	188	179	8	0554d542149cef654ff1e5e32dfbffd8990b52bd
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CNTN4 OXR1 CLSTN2 FIGN ABCB1 AGBL4 ERRFI1 TMEM178B	1.01e-06	189	179	8	3b48b0d220cc24d5170713d61fa91f5bb6c21841
ToppCell	COVID-19-kidney-PCT-S2\|kidney / Disease (COVID-19 only), tissue and cell type	CNTN4 OXR1 CLTRN CLSTN2 FIGN SLC22A5 TMEM178B WDR72	1.01e-06	189	179	8	0be5c669b6b308bd98ddb70c84877c62a6244bbd
ToppCell	facs-Pancreas\|facs / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SFRP5 CLTRN PEG3 CYFIP2 EML5 PRSS53 ABCC8 BAIAP3	1.09e-06	191	179	8	d48e5f67d384226add7d7fb2a124954136e09a82
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	OXR1 LGR4 CYFIP2 AGBL4 SLC22A5 ERRFI1 PRLR WDR72	1.18e-06	193	179	8	3866667dd221612589ae50f5c52f73a183a49ce6
ToppCell	saliva-Severe-critical_progression_d12-22_with-steroid-Myeloid-Granulocytic-Neutrophil-Neu_c4-RSAD2\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	HK3 DDO PODXL2 AGBL4 SLC22A5 TLR4 XRN1	5.20e-06	167	179	7	a54b8e03987a7b067173121902e1811a3d003692
ToppCell	COVID-19-kidney-PEC\|kidney / Disease (COVID-19 only), tissue and cell type	CNTN4 MYLK FIGN FBXL7 ARNT2 SLC39A14 TMEM178B	6.31e-06	172	179	7	36a96714a0eb6ac438648135336c9791881ddadb
ToppCell	droplet-Kidney-nan-21m\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LYPLAL1 CLTRN ACSS1 SLC34A1 TMEM37 SARDH PRLR	7.33e-06	176	179	7	0475db3f860de1e216cbdeb886f7a75b9f4fc801
ToppCell	facs-Kidney-nan-18m-Epithelial\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LYPLAL1 CLTRN SLC34A1 TMEM37 SARDH SLC23A1 PRLR	7.61e-06	177	179	7	7f58286fc8797e9bdcf8ece0849f55680905955d
ToppCell	COVID-19-kidney-Epi_(Mes)\|COVID-19 / Disease (COVID-19 only), tissue and cell type	CNTN4 MYLK OXR1 AGBL4 ARNT2 TMEM178B WDR72	7.89e-06	178	179	7	544379f5a6145429762258d426b876bb36c112f5
ToppCell	COVID-19-kidney-Distal_Epi_Doublet_(PCT)\|COVID-19 / Disease (COVID-19 only), tissue and cell type	CNTN4 OXR1 LGR4 ABCB1 AGBL4 PRLR WDR72	9.12e-06	182	179	7	9d67717a6e13bcb54c1297a3e4e3abf4e51628a3
ToppCell	droplet-Kidney-nan-21m-Epithelial\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LYPLAL1 CLTRN ACSS1 SLC34A1 TMEM37 SARDH PRLR	9.12e-06	182	179	7	942c18a27b22fb33a5200d5717cad972f3ef0576
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OBSCN MUC5B CPS1 NEB FIGN DGKK ADGRL3	9.80e-06	184	179	7	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OBSCN MUC5B CPS1 NEB FIGN DGKK ADGRL3	9.80e-06	184	179	7	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OBSCN MUC5B CPS1 NEB FIGN DGKK ADGRL3	9.80e-06	184	179	7	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CNTN4 OXR1 CLTRN FIGN ABCB1 DNAH6 ADGRL3	1.05e-05	186	179	7	5c4ffe4e4d5536ae9f8794277fe032c693e7dd56
ToppCell	COVID-19-kidney-tDL\|kidney / Disease (COVID-19 only), tissue and cell type	CNTN4 CLTRN FIGN SLC22A5 SLC39A14 TMEM178B WDR72	1.09e-05	187	179	7	d35d27ca3c0e65f92f4508e1cb98a743f44fdcdf
ToppCell	droplet-Pancreas\|droplet / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CLTRN PEG3 CYFIP2 EML5 PRSS53 ABCC8 BAIAP3	1.09e-05	187	179	7	5f4df092452d8672bda4059c794e099ba3f5a8fa
ToppCell	facs-Heart-Unknown-3m-Mesenchymal\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ACSS1 OBSCN DDO ASB14 LDHD ASB10 RNF207	1.09e-05	187	179	7	0ffb988e0da2c7205c3515eca8e9851739bff5c5
ToppCell	LPS-IL1RA-Epithelial_alveolar-AT_2-Differentiating_AT2\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ARHGAP32 CLSTN2 FIGN CYFIP2 PIGR EHF ERRFI1	1.13e-05	188	179	7	4bdf8d49af0e9da349b16e3f012e1b0eec04cc4f
ToppCell	facs-Pancreas-Endocrine-24m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PEG3 CYFIP2 EML5 PRSS53 ABCC8 BAIAP3 PRLR	1.13e-05	188	179	7	a91443aa8fa8fa87f7501c59219daa0305bd0bbf
ToppCell	facs-Heart-LA/RA-3m\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SFRP5 ACSS1 OBSCN ASB14 ABCC8 CHRNA10 RNF207	1.17e-05	189	179	7	a08b2d0fa35ffa510050ecffdc68e1b79bbe1632
ToppCell	facs-Heart-LA/RA\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SFRP5 ACSS1 OBSCN ASB14 ABCC8 CHRNA10 RNF207	1.17e-05	189	179	7	efa913d9c16fc32166b484d92b6449e8a0c59e03
ToppCell	Globus_pallidus\|World / BrainAtlas - Mouse McCarroll V32	TCIRG1 FIGN PRSS53 DGKK CHRNA10 BAIAP3	1.21e-05	126	179	6	44b63f945d5bedf1a2ca1810e7e100276ea9dd89
ToppCell	facs-Thymus-Epithelium-24m-Epithelial\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SFRP5 ANG CLTRN PEG3 PRSS53 ABCC8 TLR5	1.25e-05	191	179	7	eec14997d2bfc7e6b5a601afc43a147f6b96d668
ToppCell	facs-Thymus-Epithelium-24m-Epithelial-TECs\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SFRP5 ANG CLTRN PEG3 PRSS53 ABCC8 TLR5	1.25e-05	191	179	7	1730ec5dc1cfd2f0cba7e21555641c7bce97e09d
ToppCell	facs-Thymus-Epithelium-24m-Epithelial-epithelial_cell_of_thymus\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SFRP5 ANG CLTRN PEG3 PRSS53 ABCC8 TLR5	1.25e-05	191	179	7	4b77abc68bd72c64e7062f9527fe9d9605289ceb
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CNTN4 MYLK OXR1 CLSTN2 FIGN AGBL4 TMEM178B	1.25e-05	191	179	7	1cb02007adb344f17ef73d58890f91298c7cf5a1
ToppCell	facs-Pancreas-Endocrine-24m-Epithelial\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CLTRN PEG3 CYFIP2 PRSS53 ABCC8 BAIAP3 PRLR	1.25e-05	191	179	7	a251b134f67a0a1ef3a42f50042f128a17f20b22
ToppCell	droplet-Pancreas-Endocrine\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CLTRN PEG3 CYFIP2 PRSS53 ABCC8 PRLR SLC39A7	1.29e-05	192	179	7	0dfd1e9896c34aee0f842f8de5d0e3af62a15f68
ToppCell	PBMC-Severe-cDC_0\|Severe / Compartment, Disease Groups and Clusters	DMXL2 ANG HK3 KIAA0232 PPM1F TLR4 TLR5	1.29e-05	192	179	7	4f4774b925058191673b4ba4b4d05b8b37f61795
ToppCell	facs-Thymus-Epithelium\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SFRP5 ANG MYLK CLTRN PEG3 ARHGEF15 ABCC8	1.38e-05	194	179	7	255d6eead8da740a942a5e7d554dbd895d736d1a
ToppCell	proximal-Endothelial-Capillary_Aerocyte\|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	CDKN2B LYG2 FSTL4 ARHGEF15 ABCB1 PPM1F TMEM140	1.43e-05	195	179	7	f1cbf82484f489fe7e0b5de6a49ea28d69f04e1a
ToppCell	proximal-Endothelial-Capillary_Aerocyte-3\|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	CDKN2B LYG2 FSTL4 ARHGEF15 ABCB1 PPM1F TMEM140	1.43e-05	195	179	7	13168c9632b58dd65ecb365df3832d95e7325919
ToppCell	proximal-3-Endothelial-Capillary_Aerocyte\|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	CDKN2B LYG2 FSTL4 ARHGEF15 ABCB1 PPM1F TMEM140	1.43e-05	195	179	7	36b2e754ed7ff138ac05fb51f4494e5339669828
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	OXR1 LGR4 CYFIP2 AGBL4 EHF ARNT2 WDR72	1.48e-05	196	179	7	eea66711a16134f86e6c533a5a837ff2e0d7ca7f
ToppCell	RA-02._Fibroblast_II\|World / Chamber and Cluster_Paper	CNTN4 MTHFD1L LGR4 CLSTN2 PPP3CA FBXL7 ERRFI1	1.48e-05	196	179	7	e8cbda03837f1f26470a9d93aa7fdaa04e08e38a
ToppCell	PBMC-Mild-Lymphocyte-B-B_cell-B_naive-B_naive-1\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	TUT4 ZNF318 NSD3 FCRL3 MARF1 FCRL5	1.51e-05	131	179	6	a3a086ce6e69707ca6a042f3b15c130f81909acb
ToppCell	mild-HLA-DR-_S100A+_Monocyte\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	DMXL2 ANG HK3 NLRP3 TLR4 TLR5 ANKRD28	1.63e-05	199	179	7	d0d286eafe935f9b3aaba5b783e8911251121b4a
ToppCell	Tracheal-10x3prime_v2-Stromal-Schwann\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	SFRP5 LYPLAL1 FIGN ARHGEF40 LPL XRN1 ADGRL3	1.63e-05	199	179	7	8dc65662c3ca1db2ba0091332f0658abc0afc5de
ToppCell	Tracheal-10x3prime_v2-Stromal-Schwann-Schwann_nonmyelinating\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	SFRP5 LYPLAL1 FIGN ARHGEF40 LPL XRN1 ADGRL3	1.63e-05	199	179	7	a92718a3f1153b8d2196fd343ed5bc0ebc98cad7
ToppCell	LPS_IL1RA-Endothelial-Endothelial-Gen_Cap\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	TUT4 RNF213 FAM13B ARHGEF15 PPP3CA UBR5 ADGRL3	1.68e-05	200	179	7	dccec522ab0d7fff62ad6273b02aa9022dbbb8eb
ToppCell	saliva-Severe-critical_progression_d28-40-Lymphocytic-Lymphocytic_B-B_cell-B_c03-CD27-AIM2\|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)	CNTN4 NDOR1 HMBS SLC8A2 MROH1 CMTR2	2.20e-05	140	179	6	af9efcbaeeae69fcdac4a15fa244728b65915564
ToppCell	PND28-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CLTRN RPS11 TMEM37 IL2RB BAIAP3 NLRC3	2.20e-05	140	179	6	568a008ff103269e9fe36aa95e9d302641efed98
ToppCell	Club_cells-Donor_03\|World / lung cells shred on cell class, cell subclass, sample id	LRATD1 MUC5B PIGR CHRNA10 MAGEC2 WDR72	2.90e-05	147	179	6	5a824c89e4d045af465d7333275f8191fb29b041
ToppCell	PND01-03-samps-Mesenchymal-Pericyte\|PND01-03-samps / Age Group, Lineage, Cell class and subclass	EPHX1 OBSCN CLSTN2 SLC34A1 ABCC8 MCAT	3.50e-05	152	179	6	fc9472bc19f997103da535b035105f01429cb08e
ToppCell	18-Airway-Epithelial-Goblet-like_secretory\|Airway / Age, Tissue, Lineage and Cell class	ASPG MUC5B CNBD2 PIGR EHF TMEM178B	3.63e-05	153	179	6	14a60220e169ce642771636de982a7b02e5b2608
ToppCell	facs-Liver-Hepatocytes\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CPS1 SLC26A1 ERRFI1 SARDH SLC23A1 SLC37A4	4.04e-05	156	179	6	e2cda3ad4e5f44a80133864c5a38b766afb952ce
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-1M-Radial_glial-gliogenic/outer_RGCs_and_astrocytes\|Organoid-1M / Sample Type, Dataset, Time_group, and Cell type.	ARHGAP32 TCIRG1 BCAN CNBD2 LPL KIAA1755	4.19e-05	157	179	6	2c1219ee19a6246a3b9f5c2c1a37f26ea934a822
ToppCell	facs-Heart-Unknown-3m-Myeloid-monocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CNTN4 UGT1A5 RYR1 ABCB1 SLC34A1 PRLR	4.19e-05	157	179	6	8a393eece90fb9a1b7c356736bdb36277261fbd3
ToppCell	facs-Heart-Unknown-3m-Myeloid-monocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CNTN4 UGT1A5 RYR1 ABCB1 SLC34A1 PRLR	4.19e-05	157	179	6	8d30d8e6fae93afcada6bd68799439335cd65b69
ToppCell	facs-Heart-Unknown-3m-Myeloid\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CNTN4 UGT1A5 RYR1 ABCB1 SLC34A1 PRLR	4.19e-05	157	179	6	2ac4695d9e4ca8d4ba19c555e9a1d86ac8f398ab
ToppCell	droplet-Liver-nan-3m-Epithelial-nan\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GPR52 CPS1 PIGR ERRFI1 SARDH PRLR	4.19e-05	157	179	6	b72c6a1ed17bfc32d9dec193d934ea82e80b6bd5
ToppCell	LPS_only-Myeloid-Monocytes,_Macrophages-T-cells\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	JAK3 EML5 PTRH1 MCAT CEP97 TRPT1	4.34e-05	158	179	6	91d8c93af328c3bbebe1d8f019b94849ebc548c0
ToppCell	Globus_pallidus-Neuronal-Excitatory\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	FSTL4 RYR1 SLC8A2 PPP3CA RNF207 KCNH5	4.66e-05	160	179	6	f843287ed57d2d5a3b3f6dfb03b6934e330e6645
ToppCell	facs-Marrow-KLS-18m-Lymphocytic-BM_CD4_T_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LGR4 SLC26A1 PPP2R5B PTRH1 IL2RB NLRC3	5.71e-05	166	179	6	aa2df07eff323ded751ced8938af08223d7f2029
ToppCell	facs-Marrow-KLS-18m-Lymphocytic-CD4-positive,_alpha-beta_T_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LGR4 SLC26A1 PPP2R5B PTRH1 IL2RB NLRC3	5.71e-05	166	179	6	695298a94d62b8adab083900003ec636fbaae5d9
ToppCell	droplet-Kidney-nan-18m-Epithelial-epithelial_cell_of_proximal_tubule\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CLTRN LDHD SLC34A1 LPL ERRFI1 SARDH	6.11e-05	168	179	6	dd48da83c32d41a62f80cd7e5e5c64e42776fa27
ToppCell	facs-Kidney\|facs / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CLTRN LDHD SLC34A1 LPL TMEM37 SLC23A1	6.11e-05	168	179	6	d2f17a470e04f8f0edb111894027bcfc6ee1a12f
ToppCell	facs-Kidney-nan-3m-Epithelial-epithelial_cell_of_proximal_tubule\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DDO LDHD SLC34A1 LPL ERRFI1 SARDH	6.31e-05	169	179	6	ee27bcfe3f9a295ec5fb0a375d77d1050e5cbaad
ToppCell	facs-Kidney-nan-3m-Epithelial-epithelial_cell_of_proximal_tubule\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DDO LDHD SLC34A1 LPL ERRFI1 SARDH	6.31e-05	169	179	6	922086f218135b734b7d370b871923e50141edce
ToppCell	368C-Endothelial_cells-Endothelial-C_(Capillary_Aerocyte_)-\|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)	CDKN2B MYLK FSTL4 BCAN EML5 TMEM140	6.52e-05	170	179	6	f0b0d2d0402de3ed7322284a599646db43475761
ToppCell	368C-Endothelial_cells-Endothelial-C_(Capillary_Aerocyte_)\|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)	CDKN2B MYLK FSTL4 BCAN EML5 TMEM140	6.52e-05	170	179	6	054360a3b05f5e41221c98b122d241b1affad26a
ToppCell	3'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(non-nasal)\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CDKN2B ASPG PEG3 MUC5B PIGR ARNT2	6.73e-05	171	179	6	eddc5e05003382603ee49f74b9e2242a43021096
ToppCell	facs-Heart-Unknown-3m-Mesenchymal-atrial_myocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OBSCN DDO ASB14 NEB ABCC8 RNF207	6.95e-05	172	179	6	ee8ce9e8c9a6d3ee2be113f77743958005f4b3f0
ToppCell	facs-Heart-Unknown-3m-Mesenchymal-atrial_cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OBSCN DDO ASB14 NEB ABCC8 RNF207	6.95e-05	172	179	6	bd468a7ea6ec832dcf6a816a1e0c03fa0f176dad
ToppCell	LPS-IL1RA+antiTNF-Epithelial_alveolar-Mes-Like-Differentiating_AT1\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SLC8A2 MROH1 RNF207 FBN3 WDR72	7.54e-05	108	179	5	d620f07243c2628494e689bbfabc14c453f4b1f4
ToppCell	droplet-Lung-21m-Hematologic-lymphocytic-plasma_cell-plasma_cell\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ABCB1 NACC2 CHRNA10 SLC23A1 PRLR PCK2	7.65e-05	175	179	6	28b29f844fa46fe579ddc19039fb2d9dc5f48f3b
ToppCell	10x3'2.3-week_17-19-Neuro\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	CNTN4 BCAN FIGN KIAA1755 TMEM178B ADGRL3	7.65e-05	175	179	6	bbce8b1a160b414c0bf643c21c4e5e78fbccb7e1
ToppCell	10x3'2.3-week_17-19-Neuro-stroma-schwann_cells\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	CNTN4 BCAN FIGN KIAA1755 TMEM178B ADGRL3	7.65e-05	175	179	6	8b010220cdfb680ec839572f4933adfb85045ea6
ToppCell	10x3'2.3-week_17-19-Neuro-stroma\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	CNTN4 BCAN FIGN KIAA1755 TMEM178B ADGRL3	7.65e-05	175	179	6	0b579aeadcc06be83627391c0b01bd8605fdbdf3
ToppCell	facs\|World / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EPHX1 POLR2A ISLR NSD3 MARF1 NOTCH2	7.65e-05	175	179	6	53e96956019f984decc1c81376ebc88fbf3c4d40
ToppCell	systemic_lupus_erythematosus-flare-Lymphocytic_B-B_cell-male\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	MYLK LYPLAL1 OBSCN MARF1 BAIAP3 TMEM140	7.65e-05	175	179	6	69ed3c7c45df6bef70f5f2ff003531160bf3b32b
ToppCell	droplet-Lung-21m-Hematologic-lymphocytic-plasma_cell\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ABCB1 NACC2 CHRNA10 SLC23A1 PRLR PCK2	7.65e-05	175	179	6	ac96ca9ca309b0d72a2f5af6a3b02c7f80755750
ToppCell	facs-Trachea-24m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l6-17\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	DDO EML5 RTL1 ABCC8 BAIAP3 SLC23A1	8.15e-05	177	179	6	8abdf1d970b2f15e17e185f3e612dd5065c88757
ToppCell	facs-Kidney-nan-18m\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LYPLAL1 CLTRN TMEM37 SARDH SLC23A1 PRLR	8.15e-05	177	179	6	d4cd54c07f1e51b5485270348fb7195d53465027
ToppCell	facs-Pancreas-Exocrine-3m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PEG3 GPR52 EML5 PRSS53 RTL1 PRLR	8.40e-05	178	179	6	fcbbcc44271515de1969b4732b6441c012693d5f
ToppCell	COVID-19-kidney-PCT-S2\|COVID-19 / Disease (COVID-19 only), tissue and cell type	CNTN4 OXR1 CLTRN ABCB1 TMEM178B WDR72	8.94e-05	180	179	6	358923e4228035a3e90e2957392089219e90dcd7
ToppCell	droplet-Kidney-nan-18m-Epithelial-nan\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CLTRN ACSS1 SLC34A1 LPL ERRFI1 SARDH	8.94e-05	180	179	6	cd743f81838ba210e5bb63fe0870918d7d2b0112
ToppCell	droplet-Kidney\|droplet / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CLTRN ACSS1 SLC34A1 TMEM37 SARDH SLC37A4	8.94e-05	180	179	6	7e5f497699876ac8e1ce780626c6f5a1f6f5f079
Drug	AC1L9ZFX	RAG1 NDOR1 ANG HMBS MGAT1 LPL CHRNA10 IL2RB PRLR	1.02e-06	134	176	9	CID000504578
Drug	hydroxyl radicals	EPHX1 HK3 CES5A MAT2B MTHFD1L ACSS1 TCIRG1 HMBS DDO CLSTN2 CPS1 USP9Y ABCB1 GGT7 PAOX PPP2R5B PPP3CA PPP3CB AP2A2 CYP2R1 PPM1F LPL PTRH1 HADHA SARDH SLC37A4 OPLAH	4.66e-06	1341	176	27	CID000000961
Disease	Lymphoma	EPHX1 CDKN2B JAK3 NOTCH2	8.65e-05	40	172	4	C0024299
Disease	primary immunodeficiency disease (implicated_via_orthology)	TLR4 TLR5	1.01e-04	3	172	2	DOID:612 (implicated_via_orthology)
Disease	end stage renal disease (biomarker_via_orthology)	BGLAP ABCB1 SLC34A1 LPL	1.64e-04	47	172	4	DOID:783 (biomarker_via_orthology)
Disease	anaphylaxis	ASPG NLRP3	2.01e-04	4	172	2	C0002792
Disease	amino acid measurement, citrulline measurement	ASPG CPS1	2.01e-04	4	172	2	EFO_0005134, EFO_0009777
Disease	Colorectal Carcinoma	CNTN4 SFRP5 HK3 MTHFD1L PEG3 OBSCN CLSTN2 ISLR ABCB1 PPM1F ABCC8 TLR4 TMEM140	2.57e-04	702	172	13	C0009402
Disease	human papilloma virus infection, oropharynx cancer	CNTN4 MAT2B CPS1 PAOX	2.61e-04	53	172	4	EFO_0001668, EFO_1001931
Disease	lysine measurement, amino acid measurement	ASPG CPS1	3.34e-04	5	172	2	EFO_0005002, EFO_0005134
Disease	hyperinsulinemic hypoglycemia (implicated_via_orthology)	HK3 ABCC8	3.34e-04	5	172	2	DOID:13317 (implicated_via_orthology)
Disease	Carcinomatosis	EPHX1 ABCB1 LPL TLR4 TMEM37 PRLR	4.01e-04	163	172	6	C0205699
Disease	Carcinoma, Spindle-Cell	EPHX1 ABCB1 LPL TLR4 TMEM37 PRLR	4.01e-04	163	172	6	C0205697
Disease	Undifferentiated carcinoma	EPHX1 ABCB1 LPL TLR4 TMEM37 PRLR	4.01e-04	163	172	6	C0205698
Disease	Anaplastic carcinoma	EPHX1 ABCB1 LPL TLR4 TMEM37 PRLR	4.01e-04	163	172	6	C0205696
Disease	Carcinoma	EPHX1 ABCB1 LPL TLR4 TMEM37 PRLR	4.14e-04	164	172	6	C0007097
Disease	serum metabolite measurement	CNTN4 TRPA1 ASPG UGT1A5 CPS1 PAOX PPP3CA MROH1 LPL SAR1B SLC22A5 PTRH1 FCRL5 SARDH OPLAH	4.48e-04	945	172	15	EFO_0005653
Disease	Precursor Cell Lymphoblastic Leukemia Lymphoma	EPHX1 ABCB1 JAK3 NOTCH2	4.49e-04	61	172	4	C1961102
Disease	cystic fibrosis (is_marker_for)	MUC5B BGLAP TLR4 TLR5	4.78e-04	62	172	4	DOID:1485 (is_marker_for)
Disease	MULTIPLE PTERYGIUM SYNDROME, LETHAL TYPE	NEB RYR1	4.99e-04	6	172	2	C1854678
Disease	toxic encephalopathy (is_implicated_in)	EPHX1 ABCB1	4.99e-04	6	172	2	DOID:3602 (is_implicated_in)
Disease	non-alcoholic fatty liver disease (biomarker_via_orthology)	ABCB1 LPL TLR4 HADHA	5.72e-04	65	172	4	DOID:0080208 (biomarker_via_orthology)
Disease	glucose metabolism disease (implicated_via_orthology)	HK3 TLR4 TLR5	5.73e-04	28	172	3	DOID:4194 (implicated_via_orthology)
Disease	Vomiting	ASPG ABCB1	6.96e-04	7	172	2	C0042963
Disease	amino acid measurement, threonine measurement	ASPG CPS1	6.96e-04	7	172	2	EFO_0005134, EFO_0009775
Disease	Hyperammonemia	CPS1 TLR5	6.96e-04	7	172	2	C0220994
Disease	creatinine measurement	OBSCN CPS1 NEB RYR1 SBNO2 GGT7 PPP3CA SLC34A1 LPL SLC22A5 KIAA1755 SLC23A1 NLRC3 OPLAH WDR72	7.59e-04	995	172	15	EFO_0004518
Disease	focal segmental glomerulosclerosis (is_marker_for)	PPP3CA PPP3CB	9.24e-04	8	172	2	DOID:1312 (is_marker_for)
Disease	familial hyperlipidemia (is_implicated_in)	ABCB1 LPL	9.24e-04	8	172	2	DOID:1168 (is_implicated_in)
Disease	endometrial cancer (implicated_via_orthology)	CDKN2B ERRFI1	9.24e-04	8	172	2	DOID:1380 (implicated_via_orthology)
Disease	allergic rhinitis (is_implicated_in)	ABCB1 TLR4	9.24e-04	8	172	2	DOID:4481 (is_implicated_in)
Disease	creatinine measurement, chronic kidney disease	CPS1 SLC34A1 WDR72	1.11e-03	35	172	3	EFO_0003884, EFO_0004518
Disease	gallbladder neoplasm	CNTN4 ABCB1	1.18e-03	9	172	2	EFO_0004606
Disease	familial Mediterranean fever (is_implicated_in)	ABCB1 TLR4	1.18e-03	9	172	2	DOID:2987 (is_implicated_in)
Disease	Glaucoma	CDKN2B MYLK	1.18e-03	9	172	2	C0017601
Disease	ankylosing spondylitis (is_marker_for)	TLR4 TLR5	1.47e-03	10	172	2	DOID:7147 (is_marker_for)
Disease	otitis media (is_marker_for)	MUC5B TLR4	1.47e-03	10	172	2	DOID:10754 (is_marker_for)
Disease	Hypercholesterolemia	MYLK LPL SAR1B	1.52e-03	39	172	3	C0020443
Disease	glutamine measurement, amino acid measurement	ASPG CPS1	1.79e-03	11	172	2	EFO_0005134, EFO_0009768
Disease	invasive ductal carcinoma (is_implicated_in)	ABCB1 UBR5	1.79e-03	11	172	2	DOID:3008 (is_implicated_in)
Disease	triglycerides:total lipids ratio, low density lipoprotein cholesterol measurement	ANKRD31 LPL SLC22A5 MICA TNKS	1.90e-03	150	172	5	EFO_0004611, EFO_0020947
Disease	collagen disease (implicated_via_orthology)	TLR4 TLR5	2.15e-03	12	172	2	DOID:854 (implicated_via_orthology)
Disease	Congenital myopathy (disorder)	NEB RYR1	2.15e-03	12	172	2	C0270960
Disease	aspartate aminotransferase to alanine aminotransferase ratio	ANKRD31 RPS11 CYFIP2 ABCB1 MROH1 CPNE1	2.86e-03	239	172	6	EFO_0010934
Disease	severe combined immunodeficiency (is_implicated_in)	RAG1 JAK3	2.94e-03	14	172	2	DOID:627 (is_implicated_in)
Disease	diabetic neuropathy (implicated_via_orthology)	TRPA1 TLR4	2.94e-03	14	172	2	DOID:9743 (implicated_via_orthology)
Disease	vitamin D measurement, COVID-19	UGT1A5 CYP2R1 CEP97	2.95e-03	49	172	3	EFO_0004631, MONDO_0100096
Disease	triglycerides to total lipids in medium LDL percentage	LPL SLC22A5 MICA	3.12e-03	50	172	3	EFO_0022334
Disease	Crohn Disease	NLRP3 SLC22A5 TLR4	3.12e-03	50	172	3	C0010346
Disease	Gastro-enteropancreatic neuroendocrine tumor	IL2RB NOTCH2	3.37e-03	15	172	2	C2930967
Disease	gallstones	UGT1A5 CPS1 ABCB1 LDHD	3.73e-03	108	172	4	EFO_0004210
Disease	vitamin C measurement	SLC34A1 SLC23A1	3.84e-03	16	172	2	EFO_0600003
Disease	Pneumonia	MYLK TLR4 IL2RB	3.88e-03	54	172	3	C0032285
Disease	Lobar Pneumonia	MYLK TLR4 IL2RB	3.88e-03	54	172	3	C0032300
Disease	Pneumonitis	MYLK TLR4 IL2RB	3.88e-03	54	172	3	C3714636
Disease	Experimental Lung Inflammation	MYLK TLR4 IL2RB	3.88e-03	54	172	3	C0887898
Disease	Malignant neoplasm of breast	SFRP5 HK3 OBSCN DDO ZNF318 ABCB1 FCRL3 TRMT2A PPM1F EXOC3L1 FCRL5 CLSPN MAGEC2 NOTCH2	4.26e-03	1074	172	14	C0006142
Disease	renal fibrosis (implicated_via_orthology)	GPR52 TLR4	4.34e-03	17	172	2	DOID:0050855 (implicated_via_orthology)
Disease	serine measurement, amino acid measurement	ASPG CPS1	4.34e-03	17	172	2	EFO_0005134, EFO_0009774
Disease	copine-1 measurement	CNBD2 CPNE1	4.34e-03	17	172	2	EFO_0008102
Disease	perinatal necrotizing enterocolitis (biomarker_via_orthology)	TLR4 TLR5	4.34e-03	17	172	2	DOID:8677 (biomarker_via_orthology)
Disease	Neoplasm Invasiveness	MYLK SLC39A10 TLR4 RNF207 NOTCH2	4.57e-03	184	172	5	C0027626
Disease	sinusitis (is_marker_for)	MUC5B TLR4	4.86e-03	18	172	2	DOID:0050127 (is_marker_for)
Disease	response to antipsychotic drug	FIGN EHF PRLR	5.22e-03	60	172	3	GO_0097332
Disease	Omenn Syndrome	RAG1 JAK3	5.41e-03	19	172	2	C2700553
Disease	metabolite measurement	ASPG UGT1A5 LRATD1 CPS1 PAOX SLC34A1 LPL SLC22A5 TMEM178B	5.77e-03	560	172	9	EFO_0004725

Protein segments in the cluster

Peptide	Gene	Start	Entry
AVQAHVLGCFSPAEQ	PTRH1	171	Q86Y79
EDNCHTVLPAVFGTL	PPP2R5B	391	Q15173
VDVAAFPFDAQHCGL	CHRNA10	156	Q9GZZ6
LFLSLGLEENAHCAP	EXOC3L1	631	Q86VI1
GLEENAHCAPVLLAL	EXOC3L1	636	Q86VI1
LVFDHQPGDIFGCVA	ACSS1	321	Q9NUB1
NFLCEGHVLPAAETA	CNPY4	181	Q8N129
LIHDDLPTELCGFQG	ARHGEF40	626	Q8TER5
HTDDFLGCLNIPVRE	BAIAP3	341	O94812
LRAIVDCGFEHPSEV	DDX39A	56	O00148
VQGLFPCVDELSDIH	ARHGEF2	276	Q92974
TACVHVLLVAGADPN	ASB10	161	Q8WXI3
FGEVHLCEVDSPQDL	DDR1	621	Q08345
TDQPIACAVFAALLH	ADGRL3	921	Q9HAR2
PLHCAVINDNEGAAE	ANKRD28	791	O15084
CLADDSTLHGPIFIQ	CNTN4	16	Q8IWV2
LHLCEAPGAFIASLN	CMTR2	141	Q8IYT2
LKIQEGEAHNIFCPA	ANKIB1	366	Q9P2G1
CANGHPEVVALLVDR	ANKRD26P1	91	Q6NSI1
FPAQLVCEVTGEHER	ARHGEF15	801	O94989
HPQCLELLIQAGFDV	ASB14	326	A6NK59
ANDFECVQIIPGAKH	DMXL2	41	Q8TDJ6
CAFKIHGQELPFEAV	CLSTN2	81	Q9H4D0
FIPNIHTGACQDVDE	FBN3	236	Q75N90
VRGDAHECFVSPVAK	MTHFD1L	191	Q6UB35
ICFRDLGQAHVPGLA	TMEM37	71	Q8WXS4
TVFEALQAPACHENL	AP2A2	481	O94973
HNSDGIITFVDPRCI	ARNT2	341	Q9HBZ2
LLGPAFAECHALVDS	MUC5B	266	Q9HC84
VPSIDALHCDIGNAA	RAG1	791	P15918
SIFHRVIPDFVCQGG	RANBP2	3111	P49792
GDLCQFDHGNDPLVV	RBM27	291	Q9P2N5
EVAEQCHGPITLDFA	JAK3	371	P52333
LTEVHLDGQPFLRCD	MICA	46	Q29983
AHLGIVSQEPILFDC	ABCB1	1111	P08183
FQEGERVLCFHGPLL	MORF4L1	11	Q9UBU8
PLHVAAVCGQASLID	ANKRD27	466	Q96NW4
CENIDGILPLHDAVA	ANKRD31	1216	Q8N7Z5
QEACARIGAHIATPE	BCAN	176	Q96GW7
LRFVENGCHDNPTLD	PODXL2	541	Q9NZ53
RCPLHAAVAADAQGV	NOTCH2	1911	Q04721
LDVAHLCQEAVVGPL	FIGN	691	Q5HY92
DAFGLHEKCQLAVIP	DGKK	561	Q5KSL6
ITIAFSCNPDHGIED	OGFOD3	301	Q6PK18
CEAGVAELHIQDALP	MYLK	561	Q15746
QGEDILDAVHGFQLC	LRRTM2	346	O43300
ALIEVGPDHFCVFAN	MAGEC2	196	Q9UBF1
HFVPGSCRLVEEEVN	MAT2B	11	Q9NZL9
ISPEGAQAIAHALCA	NLRC3	846	Q7RTR2
CAVEEHPVGEASILA	MTIF2	616	P46199
SAELFPIIVSQDCGH	MGAT1	131	P26572
VPSLACAAAHAGDVE	ASPG	401	Q86U10
QVVILADPDGHEICF	GLOD4	256	Q9HC38
FLRAHPCVSDQELGL	KCNK4	46	Q9NYG8
DFEGNPLHNCLVASE	KIAA1755	156	Q5JYT7
LDQVSGIPGCIFVHA	MYG1	331	Q9HB07
VQGEAACVSIPHLDL	FAM13B	456	Q9NYF5
ALAVEFQTIHCAPGD	KCNH5	561	Q8NCM2
FVLALHCDVDGQPAP	ISLR	251	O14498
DFVEHSARLCQPEGI	PCK2	46	Q16822
QAVVGDLLELHCEAP	FCRL5	576	Q96RD9
AAVAAALCLGIVAPH	GGT7	166	Q9UJ14
VLHVECSFEPEGIAS	KIAA0232	1051	Q92628
FTPFQLCHAEVQVGD	KPTN	141	Q9Y664
LIPGVAESVATCHFN	LPL	56	P06858
AVHLLFCGPNEVDSF	OR4F5	156	Q8NH21
ASHIAVVILFFGPCI	OR4K5	241	Q8NGD3
PSIIGVNNHECGFLL	CES5A	336	Q6NT32
PLVAELVVQNACGHL	LRATD1	186	Q96KN4
RDLPSFNGCHALEEI	LGR4	356	Q9BXB1
EAFNVALCELAGHLP	GDPGP1	326	Q6ZNW5
NVVVACENGLPVHLD	ANG	126	P03950
CENGLPVHLDQSIFR	ANG	131	P03950
EEVCDLLHAAPFQNI	CYFIP2	1041	Q96F07
PALDEQARADVIHGC	MROH1	856	Q8NDA8
FQVGLFPGHCVELIN	ARHGAP32	306	A7KAX9
EGLLCRVVHSPEFNL	GARIN1B	56	Q96KD3
PGASDVELVQHVCAA	HK3	376	P52790
AGNLTVIFVFHCAPL	GPR52	56	Q9Y2T5
AFIHSLPGCQDIADE	PHC3	926	Q8NDX5
QIAEPGECHFLDQPA	DQX1	421	Q8TE96
VCGESFVNPAELADH	PEG3	1286	Q9GZU2
AAHVQRFCQVLGLDP	NDOR1	256	Q9UHB4
LNPDCDELADHIGFQ	BGLAP	76	P02818
ELHPSFDIVVNCSGL	DDO	171	Q99489
CNHIFVDTGLPDLAV	SLC34A1	336	Q06495
AEAACAEQAPHFLLR	OBSCN	101	Q5VST9
LFPDCRVISGHQEAL	MCAT	231	Q8IVS2
LPIDIDQLSGRDFCH	OXR1	286	Q8N573
GSHVPFCLFAENVAL	OSGIN2	246	Q9Y236
FLCLLLIHNEPADVG	SLC37A4	181	O43826
LGIVGECNIQFALHP	CPS1	691	P31327
GAQEEAQCPTLHFLE	CENPB	491	P07199
EDFLDGILGAVNHCQ	DNAH6	531	Q9C0G6
GLSDEHVFEVICPSI	EPHX1	171	P07099
FDVVSLCPNLEHLDV	FBXL7	231	Q9UJT9
HIACFPVQLDTLSDG	CEP97	801	Q8IW35
FCNIVPLGIFHATSE	CYP2R1	371	Q6VVX0
NCIPFQEFDINGEHL	EHF	71	Q9NZC4
AQEPGVAASLRCHAE	FSTL4	351	Q6MZW2
VFSDDGIIVIHPVDC	FSTL4	456	Q6MZW2
LNCLVAPTLFLEFHG	LDHD	316	Q86WU2
FFHLPDALEIEACQV	IL2RB	366	P14784
HLALLVQRADVPFCG	GIMD1	106	P0DJR0
QGIIDFLVSQHPIAC	AGBL4	241	Q5VU57
VAELLLLHGAEPNCA	CDKN2B	61	P42772
ALHPVFEGDNVILRC	FCRL3	106	Q96P31
EHFITCVPGVNIATA	MARF1	1051	Q9Y4F3
EVGQRHCVDPAVIAA	LYG2	86	Q86SG7
GVLPELFQCHGTADE	LYPLAL1	166	Q5VWZ2
EVEAVIPDHCIFASN	HADHA	461	P40939
EEPIRCAAVNADGIH	EML5	366	Q05BV3
GAICKRENPHDAVVF	HMBS	111	P08397
DVICDPQALNDFLHG	BICRA	11	Q9NZM4
EAPITVCGDIHGQFF	PPP3CB	91	P16298
PNLHGDIFVNCFLSA	SLC22A5	366	O76082
VFCHELPHELGDFAV	SLC39A10	706	Q9ULF5
VAILCEEFPHELGDF	SLC39A14	371	Q15043
LFGTDAPAVVNCLHI	RYR1	3056	P21817
IDAPVTVCGDIHGQF	PPP3CA	81	Q08209
LAQLQAVPAEFECIH	CPNE1	231	Q99829
LLACDGFFDVVPHQE	PPM1F	356	P49593
LTAAHCFVGAPNELL	PRSS56	141	P0CW18
GFVVLPAFASVHVLC	PAOX	366	Q6QHF9
AEGCPEELAVHLGFN	PLA2G4D	271	Q86XP0
ELQGAFDEHIGPLCT	NLRP3	306	Q96P20
VHLSPCFRDVQIGDI	RPS11	111	P62280
LCEFFGVRVTPQEGH	RTL1	1196	A6NKG5
LLAEGENTPFAEHCR	RNF207	411	Q6ZRF8
NVEFHCGRAEDLVPT	TRMT2A	481	Q8IZ69
KCHRQGFDPEIAALI	TMEM178B	111	H3BS89
PLDNDLCIAVQFGHL	SFRP5	156	Q5T4F7
TLQCHQFPELEALGV	TMEM140	61	Q9NV12
GLALADVVHEAQEPC	OPLAH	521	O14841
FLEPCTQQGLGAHIV	SPATA31A7	791	Q8IWB4
PAINGIVFLVDCADH	SAR1A	91	Q9NR31
AQADPAALAHQGCDI	SBNO2	1296	Q9Y2G9
EELIQGAQCVHSPRF	SKIV2L	1006	Q15477
ENLGPHEEDQVVCGF	ERRFI1	101	Q9UJM3
SHCEIAVFIDGPLAL	TRPT1	171	Q86TN4
DPLHEELLGQGCVFQ	SARDH	486	Q9UL12
PLHVDACLGGFLIVF	SGPL1	311	O95470
CFVDALNVVPHVFLL	ABCC8	26	Q09428
EILGLHQAFLPEGEC	CNBD2	421	Q96M20
EECQVGGLVAFEPHA	CLSPN	441	Q9HAW4
FFLVTAIHAELCQPG	CLTRN	6	Q9HBJ8
AIHAELCQPGAENAF	CLTRN	11	Q9HBJ8
DHPVFCALVNGEGEV	SUPT6H	791	Q7KZ85
FLEPCTQQGLGAHIV	SPATA31A3	791	Q5VYP0
VLTAAHCFIGRQAPE	PRSS53	336	Q2L4Q9
PLAEDSGLHIIAACN	RNF213	2511	Q63HN8
ALAGLAFCDPEKQHI	URGCP	861	Q8TCY9
DPVEKGRCTAIHFAA	TRPA1	266	O75762
ALGQPELAAHCLQEA	TTC24	166	A2A3L6
FLEPCTQQGLGAHIV	SPATA31A1	791	Q5TZJ5
AVPFLLAEALCVGHD	SLC23A1	61	Q9UHI7
FLEPCTQQGLGAHIV	SPATA31A5	791	Q5VU36
AAGFHTVVIDCAPLL	SLC26A1	606	Q9H2B4
PHEVGDFAILVQSGC	SLC39A7	361	Q92504
CDGDIVIFNRQPTLH	POLR2A	451	P24928
HAEVVSLLLCQGADP	TNKS	261	O95271
HNITDVCELAVGPAG	PRLR	431	P16471
HPVENFLIVGCADDS	WDR72	566	Q3MJ13
QQHGVIPDRDAEFCL	XRN1	1091	Q8IZH2
FDVVLTDPFHLCAAV	UGT1A5	146	P35504
GHVRAVAEACQPVVD	USP9Y	1166	O00507
HCALGPEVANVAKFL	PIGR	256	P01833
LFQVAHDPDCGDVVR	TAMM41	276	Q96BW9
FVCARGLIVQDHSDP	NSD3	866	Q9BZ95
AFGHVLVCELAFPLT	PLEKHG2	871	Q9H7P9
QIFLVCEHELEPLQG	TLR5	181	O60602
PAINGIVFLVDCADH	SAR1B	91	Q9Y6B6
CIAIEDPFDLNHNLG	TUT4	1226	Q5TAX3
ADAPCLGHIDFQELR	TCFL5	116	Q9UL49
DFIPGVAIAANIIHE	TLR4	711	O00206
ALPLGHLDIADACFS	TBC1D2B	76	Q9UPU7
CEEFLGDPISGEQHV	ZNF318	1141	Q5VUA4
FFVGQLEAPQHVVSC	WDR81	1701	Q562E7
CHVFPFLQQEEARLG	TCIRG1	241	Q13488
CVVGPNHAAFLLEDG	UBR5	51	O95071
EGHVILCNISSFLDP	WDR64	836	B1ANS9
PEILLSVIEVCGHNF	SLC8A2	141	Q9UPR5
HIEIPNFGNTVLGCL	NACC2	6	Q96BF6
VIGEFPGVVHCLDFQ	NEB	4511	P20929