Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	promoter-specific chromatin binding	SUZ12 ATF2 NFE2L1	3.78e-04	83	34	3	GO:1990841
GeneOntologyMolecularFunction	tRNA binding	TRMT10B EIF1AX EIF1AY	4.34e-04	87	34	3	GO:0000049
GeneOntologyCellularComponent	multi-eIF complex	EIF1AX EIF1AY	1.73e-05	4	36	2	GO:0043614
GeneOntologyCellularComponent	RSC-type complex	SMARCC1 SUZ12	2.99e-04	15	36	2	GO:0016586
GeneOntologyCellularComponent	eukaryotic 48S preinitiation complex	EIF1AX EIF1AY	4.34e-04	18	36	2	GO:0033290
GeneOntologyCellularComponent	eukaryotic 43S preinitiation complex	EIF1AX EIF1AY	4.84e-04	19	36	2	GO:0016282
GeneOntologyCellularComponent	translation preinitiation complex	EIF1AX EIF1AY	5.37e-04	20	36	2	GO:0070993
Domain	TIF_eIF-1A_CS	EIF1AX EIF1AY	3.03e-06	2	33	2	IPR018104
Domain	TIF_eIF-1A	EIF1AX EIF1AY	9.07e-06	3	33	2	PD005579
Domain	IF1A	EIF1AX EIF1AY	9.07e-06	3	33	2	PS01262
Domain	eIF-1a	EIF1AX EIF1AY	1.81e-05	4	33	2	PF01176
Domain	S1_IF1_TYPE	EIF1AX EIF1AY	1.81e-05	4	33	2	PS50832
Domain	eIF1a	EIF1AX EIF1AY	1.81e-05	4	33	2	SM00652
Domain	RNA-binding_domain_S1_IF1	EIF1AX EIF1AY	1.81e-05	4	33	2	IPR006196
Domain	TIF_eIF-1A	EIF1AX EIF1AY	1.81e-05	4	33	2	IPR001253
Domain	SAPAP	DLGAP4 DLGAP5	3.02e-05	5	33	2	IPR005026
Domain	GKAP	DLGAP4 DLGAP5	3.02e-05	5	33	2	PF03359
Domain	NA-bd_OB-fold	CCAR1 EIF1AX EIF1AY	4.19e-04	83	33	3	IPR012340
Domain	PA	RNF130 RNF150	5.08e-04	19	33	2	PF02225
Domain	PA_domain	RNF130 RNF150	5.08e-04	19	33	2	IPR003137
Domain	zf-MYND	RUNX1T1 EGLN1	6.23e-04	21	33	2	PF01753
Domain	Znf_MYND	RUNX1T1 EGLN1	6.84e-04	22	33	2	IPR002893
Domain	ZF_MYND_1	RUNX1T1 EGLN1	6.84e-04	22	33	2	PS01360
Domain	ZF_MYND_2	RUNX1T1 EGLN1	6.84e-04	22	33	2	PS50865
Domain	SANT_dom	SMARCC1 MIER1	9.58e-04	26	33	2	IPR017884
Domain	SANT	SMARCC1 MIER1	1.11e-03	28	33	2	PS51293
Domain	bZIP_1	ATF2 NFE2L1	1.64e-03	34	33	2	PF00170
Domain	Myb_DNA-binding	SMARCC1 MIER1	1.74e-03	35	33	2	PF00249
Domain	TF_DNA-bd	ATF2 NFE2L1	1.94e-03	37	33	2	IPR008917
Domain	MYB_LIKE	SMARCC1 MIER1	2.05e-03	38	33	2	PS50090
Domain	SANT	SMARCC1 MIER1	3.52e-03	50	33	2	SM00717
Domain	BRLZ	ATF2 NFE2L1	3.80e-03	52	33	2	SM00338
Domain	zf-RING_2	RNF130 RNF150	3.80e-03	52	33	2	PF13639
Domain	SANT/Myb	SMARCC1 MIER1	3.80e-03	52	33	2	IPR001005
Domain	BZIP	ATF2 NFE2L1	3.94e-03	53	33	2	PS50217
Domain	BZIP_BASIC	ATF2 NFE2L1	3.94e-03	53	33	2	PS00036
Domain	bZIP	ATF2 NFE2L1	4.09e-03	54	33	2	IPR004827
Domain	Znf_RING/FYVE/PHD	RNF130 RNF150 WDR59 SP140	8.38e-03	459	33	4	IPR013083
Pubmed	H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.	ANKRD11 CCAR1 SMARCC1 SNIP1 SUZ12 ATF2 MIER1 ZC3H13 NFKBIL1 DLGAP5	6.83e-07	1294	37	10	30804502
Pubmed	A novel gene family NBPF: intricate structure generated by gene duplications during primate evolution.	NBPF10 NBPF19 NBPF20	1.45e-06	21	37	3	16079250
Pubmed	The interaction between eukaryotic initiation factor 1A and eIF5 retains eIF1 within scanning preinitiation complexes.	EIF1AX EIF1AY	3.30e-06	3	37	2	24319994
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	CCAR1 MAGI1 SMARCC1 TRAF3IP1 CCDC177 DLGAP4 DLGAP5 NGEF	6.35e-06	963	37	8	28671696
Pubmed	SETD1A Methyltransferase Is Physically and Functionally Linked to the DNA Damage Repair Protein RAD18.	CCAR1 SMARCC1 SNIP1 EIF1AX ZC3H13	6.79e-06	251	37	5	31076518
Pubmed	Leukemia associated RUNX1T1 gene reduced proliferation and invasiveness of glioblastoma cells.	RUNX1T1 EGLN1	1.10e-05	5	37	2	34369622
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	CCAR1 SMARCC1 SUZ12 ATF2 MIER1 ZC3H13 DLGAP5	1.51e-05	774	37	7	15302935
Pubmed	Structural basis for the nuclear export activity of Importin13.	EIF1AX EIF1AY	1.65e-05	6	37	2	23435562
Pubmed	The E3 ubiquitin ligase GREUL1 anteriorizes ectoderm during Xenopus development.	RNF130 RNF150	1.65e-05	6	37	2	12435366
Pubmed	ATRX In-Frame Fusion Neuroblastoma Is Sensitive to EZH2 Inhibition via Modulation of Neuronal Gene Signatures.	SMARCC1 SUZ12	2.30e-05	7	37	2	31631027
Pubmed	Assembly and function of a TCR alpha enhancer complex is dependent on LEF-1-induced DNA bending and multiple protein-protein interactions.	RUNX1T1 ATF2	2.30e-05	7	37	2	7774816
Pubmed	Ring finger protein20 regulates hepatic lipid metabolism through protein kinase A-dependent sterol regulatory element binding protein1c degradation.	CCAR1 RNF130	4.93e-05	10	37	2	24425205
Pubmed	Proximity labeling reveals OTUD3 as a DNA-binding deubiquitinase of cGAS.	SUZ12 MIER1 EIF1AX	5.30e-05	68	37	3	36966392
Pubmed	Lineage-specific gene duplication and loss in human and great ape evolution.	NBPF19 NBPF20 EIF1AY	5.53e-05	69	37	3	15252450
Pubmed	Deconstruction of the SS18-SSX fusion oncoprotein complex: insights into disease etiology and therapeutics.	SUZ12 ATF2	6.02e-05	11	37	2	22439931
Pubmed	Sex differences in structure and expression of the sex chromosome genes CHD1Z and CHD1W in zebra finches.	EIF1AX EIF1AY	8.53e-05	13	37	2	14660691
Pubmed	HIF1 inhibitor acriflavine rescues early-onset preeclampsia phenotype in mice lacking placental prolyl hydroxylase domain protein 2.	HYOU1 EGLN1	8.53e-05	13	37	2	36227697
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	SMARCC1 HYOU1 ATF2 NFE2L1 MIER1 ZC3H13 DLGAP5	1.27e-04	1084	37	7	11544199
Pubmed	Yippee like 4 (Ypel4) is essential for normal mouse red blood cell membrane integrity.	EIF1AX EIF1AY	1.48e-04	17	37	2	34354145
Pubmed	JAKMIP1, a Novel Regulator of Neuronal Translation, Modulates Synaptic Function and Autistic-like Behaviors in Mouse.	DLGAP4 EIF1AY	1.48e-04	17	37	2	26627310
Pubmed	Exp5 exports eEF1A via tRNA from nuclei and synergizes with other transport pathways to confine translation to the cytoplasm.	EIF1AX EIF1AY	1.67e-04	18	37	2	12426392
Pubmed	SNIP1 and PRC2 coordinate cell fates of neural progenitors during brain development.	SNIP1 SUZ12	1.67e-04	18	37	2	37553330
Pubmed	TRIM28 interacts with EZH2 and SWI/SNF to activate genes that promote mammosphere formation.	SMARCC1 SUZ12	1.67e-04	18	37	2	28068325
Pubmed	Yin Yang 1 Orchestrates a Metabolic Program Required for Both Neural Crest Development and Melanoma Formation.	EIF1AX EIF1AY	2.51e-04	22	37	2	30951662
Pubmed	Comprehensive identification of human bZIP interactions with coiled-coil arrays.	ATF2 NFE2L1	2.75e-04	23	37	2	12805554
Pubmed	Functional coherence of the human Y chromosome.	EIF1AX EIF1AY	3.25e-04	25	37	2	9381176
Pubmed	Anteroposterior Limb Skeletal Patterning Requires the Bifunctional Action of SWI/SNF Chromatin Remodeling Complex in Hedgehog Pathway.	SMARCC1 SUZ12	4.39e-04	29	37	2	26959361
Pubmed	ZMYM3 regulates BRCA1 localization at damaged chromatin to promote DNA repair.	SMARCC1 SUZ12 MIER1	5.49e-04	150	37	3	28242625
Pubmed	Identification of bZIP interaction partners of viral proteins HBZ, MEQ, BZLF1, and K-bZIP using coiled-coil arrays.	ATF2 NFE2L1	5.69e-04	33	37	2	20102225
Pubmed	Ubiquitin-assisted phase separation of dishevelled-2 promotes Wnt signalling.	SNIP1 EGLN1 NFKBIL1	6.74e-04	161	37	3	36398662
Pubmed	Spatiotemporal-resolved protein networks profiling with photoactivation dependent proximity labeling.	HDDC3 SMARCC1 EIF1AX ZC3H13	8.35e-04	399	37	4	35987950
Pubmed	Networks of bZIP protein-protein interactions diversified over a billion years of evolution.	ATF2 NFE2L1	8.37e-04	40	37	2	23661758
Pubmed	BioID-based intact cell interactome of the Kv1.3 potassium channel identifies a Kv1.3-STAT3-p53 cellular signaling pathway.	RABL6 MAGI1 LLGL1 HYOU1 EGLN1	8.76e-04	708	37	5	39231216
Pubmed	Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1.	VGLL4 SUZ12	8.80e-04	41	37	2	8590280
Pubmed	A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract.	SMARCC1 RNF130 ATF2 NFE2L1 EGLN1	8.82e-04	709	37	5	22988430
Pubmed	Transcription factor protein interactomes reveal genetic determinants in heart disease.	CCAR1 SMARCC1 RUNX1T1 DLGAP5	9.33e-04	411	37	4	35182466
Interaction	ERP29 interactions	RNF130 HYOU1 ATF2 EGLN1 SP140	2.63e-06	124	36	5	int:ERP29
Interaction	NBPF20 interactions	SNIP1 NBPF20	3.09e-05	5	36	2	int:NBPF20
Cytoband	Ensembl 112 genes in cytogenetic band chr2q37	TRAF3IP1 SP140 NGEF	8.08e-04	226	37	3	chr2q37
GeneFamily	Neuroblastoma breakpoint family	NBPF10 NBPF19 NBPF20	5.16e-06	23	27	3	662
GeneFamily	Zinc fingers MYND-type	RUNX1T1 EGLN1	4.43e-04	21	27	2	87
GeneFamily	Basic leucine zipper proteins	ATF2 NFE2L1	2.42e-03	49	27	2	506
GeneFamily	GATA zinc finger domain containing\|Myb/SANT domain containing	SMARCC1 MIER1	2.82e-03	53	27	2	532
CoexpressionAtlas	DevelopingGonad_P2_epididymis_emap-30199_k-means-cluster#3_top-relative-expression-ranked_1000	ANKRD11 SMARCC1 VGLL4 RUNX1T1 ATF2 ZC3H13	2.08e-06	249	33	6	gudmap_developingGonad_P2_epididymis_1000_k3
CoexpressionAtlas	DevelopingGonad_e18.5_ovary_emap-12283_k-means-cluster#2_top-relative-expression-ranked_1000	ANKRD11 SMARCC1 VGLL4 RUNX1T1 ZC3H13	1.71e-05	210	33	5	gudmap_developingGonad_e18.5_ovary_1000_k2
CoexpressionAtlas	DevelopingGonad_e12.5_epididymis_emap-29139_k-means-cluster#3_top-relative-expression-ranked_1000	ANKRD11 VGLL4 HYOU1 RUNX1T1 ZC3H13	4.66e-05	259	33	5	gudmap_developingGonad_e12.5_epididymis_k3_1000
CoexpressionAtlas	DevelopingGonad_e18.5_epididymis_emap-13166_k-means-cluster#3_top-relative-expression-ranked_1000	ANKRD11 SMARCC1 VGLL4 RUNX1T1 ZC3H13	6.86e-05	281	33	5	gudmap_developingGonad_e18.5_epididymis_1000_k3
CoexpressionAtlas	DevelopingGonad_e16.5_epididymis_emap-29702_k-means-cluster#2_top-relative-expression-ranked_1000	ANKRD11 SMARCC1 VGLL4 RUNX1T1 ZC3H13	7.21e-05	284	33	5	gudmap_developingGonad_e16.5_epididymis_1000_k2
CoexpressionAtlas	FacebaseRNAseq_e10.5_Mandibular Arch_top-relative-expression-ranked_500_k-means-cluster#5	RABL6 CCAR1 SUZ12 TRAF3IP1	1.91e-04	186	33	4	Facebase_RNAseq_e10.5_Mandibular Arch_500_K5
ToppCell	368C-Fibroblasts-Fibroblast-C_(Myofibroblast)\|368C / Donor, Lineage, Cell class and subclass (all cells)	NBPF10 MAGI1 RUNX1T1 TRAF3IP1	1.13e-05	168	37	4	1bc6a1915d48f547385ed4f44e118bcc8a4a7b6c
ToppCell	368C-Fibroblasts-Fibroblast-C_(Myofibroblast)-\|368C / Donor, Lineage, Cell class and subclass (all cells)	NBPF10 MAGI1 RUNX1T1 TRAF3IP1	1.13e-05	168	37	4	69f534de0f9a293047bea03cb1b78551087a8df5
Disease	uveal melanoma (implicated_via_orthology)	EIF1AX EIF1AY	1.37e-06	2	35	2	DOID:6039 (implicated_via_orthology)
Disease	unipolar depression, mood disorder, response to antidepressant	NFE2L1 SCN8A	1.23e-04	14	35	2	EFO_0003761, EFO_0004247, GO_0036276
Disease	Epilepsy, Cryptogenic	ANKRD11 SCN8A	4.28e-03	82	35	2	C0086237
Disease	Awakening Epilepsy	ANKRD11 SCN8A	4.28e-03	82	35	2	C0751111
Disease	Aura	ANKRD11 SCN8A	4.28e-03	82	35	2	C0236018
Disease	Neurodevelopmental Disorders	ANKRD11 SCN8A	5.46e-03	93	35	2	C1535926
Disease	hair colour measurement	ANKRD11 VGLL4 DLGAP4 NGEF	5.86e-03	615	35	4	EFO_0007822
Disease	suntan	ANKRD11 DLGAP4	6.66e-03	103	35	2	EFO_0004279
Disease	Epilepsy	ANKRD11 SCN8A	7.43e-03	109	35	2	C0014544

Protein segments in the cluster

Peptide	Gene	Start	Entry
QKDKEPRDRRKDRGA	ANKRD11	1176	Q6UB99
DRGDQVPNRKDDRSR	CCAR1	306	Q8IX12
GRRRRAANEDPDEKR	ATF2	341	P15336
ERAKAGEPKRRSRSN	DLGAP4	186	Q9Y2H0
ADQQARRQERKPKDR	NFE2L1	756	Q14494
KEEGKEERRRRQQRP	RABL6	681	Q3YEC7
ARDRNQRRLGDAAKK	RNF130	226	Q86XS8
FRRQGADPQREKLKQ	LLGL1	6	Q15334
KARARPDNERQKDRG	TRAF3IP1	221	Q8TDR0
PDNERQKDRGNRERD	TRAF3IP1	226	Q8TDR0
KDRAPEGRRDAQAER	MAGI1	1326	Q96QZ7
KRRTPDRTKENGFDR	RUNX1T1	241	Q06455
ARKHRQQRRKDPEGT	HDDC3	16	Q8N4P3
NRRRGKNENESEKRE	EIF1AY	11	O14602
RARRAQEALGDREPK	NFKBIL1	261	Q9UBC1
DEDLDQEPRRNKKRG	MEIS3P2	236	A8K0S8
RKGQRAKDVRENPRA	HYOU1	291	Q9Y4L1
KPKQDDAGRIAARNR	DLGAP5	561	Q15398
REPRKAAARRDNASG	EGLN1	91	Q9GZT9
QGRRAKEAAERKERE	CCDC177	566	Q9NQR7
EQRLGSREKSDDPRK	GRK7	436	Q8WTQ7
NDFDEKSERPAKRRR	MIER1	466	Q8N108
RDRNQRRLGDAAKKA	RNF150	241	Q9ULK6
KVKQEREDHPRRGRE	SNIP1	106	Q8TAD8
KERRRGRKEGEEDQN	NBPF10	1331	Q6P3W6
KERRRGRKEGEEDQN	NBPF10	2551	Q6P3W6
KERRRGRKEGEEDQN	NBPF10	3696	Q6P3W6
KERRRGRKEGEEDQN	NBPF19	816	A0A087WUL8
KERRRGRKEGEEDQN	NBPF19	2036	A0A087WUL8
KERRRGRKEGEEDQN	NBPF19	3256	A0A087WUL8
KERRRGRKEGEEDQN	NBPF20	716	P0DPF2
KERRRGRKEGEEDQN	NBPF20	1936	P0DPF2
KERRRGRKEGEEDQN	NBPF20	3156	P0DPF2
KERRRGRKEGEEDQN	NBPF20	4376	P0DPF2
DDPQRSQNKDRRKLG	NGEF	691	Q8N5V2
PERRDRKASANARKR	SMARCC1	311	Q92922
NKTANGDCRRDPRER	VGLL4	86	Q14135
RDEKDFRNPGQEVRK	ZSCAN32	386	Q9NX65
PARRKRNREDGEKTF	SUZ12	281	Q15022
EKQQRAEEGRRERAK	SCN8A	1956	Q9UQD0
PRERERDQHDKNKRL	WDR59	836	Q6PJI9
EEEGRNSPRKRNQDK	SP140	271	Q13342
EKERRKANRAENPGI	TRMT10B	86	Q6PF06
GRDFERQREKRDKPR	ZC3H13	301	Q5T200
RNPRDGHDERKSKKR	ZC3H13	811	Q5T200
NRRRGKNENESEKRE	EIF1AX	11	P47813