Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyCellularComponent	fibrillar center	DAB2 CC2D1A PAK6 TCOF1	2.00e-04	156	39	4	GO:0001650
MousePheno	mandible hypoplasia	ZFHX4 TCOF1 NABP2	2.91e-05	34	25	3	MP:0000460
Domain	HMGI/Y_DNA-bd_CS	PRR12 PRB1 PRB2	3.36e-05	31	38	3	IPR000637
Domain	ZnF_U1	ZNF385A ZFHX4	1.58e-03	29	38	2	SM00451
Domain	Znf_U1	ZNF385A ZFHX4	1.58e-03	29	38	2	IPR003604
Domain	Kinase-like_dom	ABL1 PAK6 VRK3 WNK1 PI4KB	4.60e-03	542	38	5	IPR011009
Domain	-	DAB2 OSBP2 FARP1 APBB1IP	7.96e-03	391	38	4	2.30.29.30
Domain	PH_dom-like	DAB2 OSBP2 FARP1 APBB1IP	1.07e-02	426	38	4	IPR011993
Domain	PH	OSBP2 FARP1 APBB1IP	1.12e-02	229	38	3	PF00169
Domain	PROTEIN_KINASE_ATP	ABL1 PAK6 VRK3 WNK1	1.37e-02	459	38	4	PS00107
Pubmed	Fractionation and characterization of basic proline-rich peptides of human parotid saliva and the amino acid sequence of proline-rich peptide P-E.	PRB1 PRB2	1.23e-06	2	39	2	7118863
Pubmed	Basic proline-rich proteins from human parotid saliva: complete covalent structure of protein IB-9 and partial structure of protein IB-6, members of a polymorphic pair.	PRB1 PRB2	1.23e-06	2	39	2	6924859
Pubmed	Clones from the human gene complex coding for salivary proline-rich proteins.	PRB1 PRB2	1.23e-06	2	39	2	6089212
Pubmed	A probability-based approach for high-throughput protein phosphorylation analysis and site localization.	DAB2 CC2D1A GTF2F1 TBRG4 WNK1 TCOF1 NUP35	1.31e-06	503	39	7	16964243
Pubmed	Src homology 2 domain as a specificity determinant in the c-Abl-mediated tyrosine phosphorylation of the RNA polymerase II carboxyl-terminal repeated domain.	GTF2F1 ABL1	3.67e-06	3	39	2	7533294
Pubmed	The structure and evolution of the human salivary proline-rich protein gene family.	PRB1 PRB2	3.67e-06	3	39	2	8422499
Pubmed	The involvement of proline-rich protein Mus musculus predicted gene 4736 in ocular surface functions.	PRB1 PRB2	7.34e-06	4	39	2	27588265
Pubmed	Length polymorphisms in human proline-rich protein genes generated by intragenic unequal crossing over.	PRB1 PRB2	7.34e-06	4	39	2	2851479
Pubmed	Structural Basis for Interactions Between Contactin Family Members and Protein-tyrosine Phosphatase Receptor Type G in Neural Tissues.	CNTN3 CNTN6	1.22e-05	5	39	2	27539848
Pubmed	Differential RNA splicing and post-translational cleavages in the human salivary proline-rich protein gene system.	PRB1 PRB2	1.83e-05	6	39	2	2993301
Pubmed	Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.	GTF2F1 ZC3H18 ARID1A WNK1 TCOF1 PRRC2B	4.62e-05	588	39	6	38580884
Pubmed	Nucleoplasmic calcium regulates cell proliferation through legumain.	TBRG4 ARID1A	6.70e-05	11	39	2	21237226
Pubmed	TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.	LMOD1 TBRG4 ARID1A PI4KB PRRC2B ACSS3	7.26e-05	638	39	6	31182584
Pubmed	Identification and functional characterization of transcriptional activators in human cells.	PRR12 VRK3 ZFHX4 ARID1A PCLO	8.00e-05	398	39	5	35016035
Pubmed	A role for Nr-CAM in the patterning of binocular visual pathways.	CNTN3 CNTN6	8.03e-05	12	39	2	16701205
Pubmed	Motor phenotypes and molecular networks associated with germline deficiency of Ciz1.	ZFHX4 NUP35	8.03e-05	12	39	2	27163549
Pubmed	Pioneering axons regulate neuronal polarization in the developing cerebral cortex.	CNTN3 CNTN6	9.48e-05	13	39	2	24559674
Pubmed	Multisite dependency of an E3 ligase controls monoubiquitylation-dependent cell fate decisions.	TCOF1 PI4KB	1.27e-04	15	39	2	29999490
Pubmed	Interspecific backcross mice show sex-specific differences in allelic inheritance.	ABL1 HOXD4	1.27e-04	15	39	2	1916246
Pubmed	A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning.	DAB2 CC2D1A GTF2F1 LIMCH1 WNK1 TCOF1 PI4KB	1.38e-04	1038	39	7	26673895
Pubmed	Comparative Application of BioID and TurboID for Protein-Proximity Biotinylation.	PRR12 TBRG4 ARID1A PRRC2B NUP35	1.53e-04	457	39	5	32344865
Pubmed	Functional genomics identifies therapeutic targets for MYC-driven cancer.	PAK6 WNK1 PI4KB	2.13e-04	103	39	3	22623531
Pubmed	NuRD subunit CHD4 regulates super-enhancer accessibility in rhabdomyosarcoma and represents a general tumor dependency.	ZC3H18 ZFHX4 TCOF1	2.13e-04	103	39	3	32744500
Pubmed	A molecular genetic linkage map of mouse chromosome 2.	ABL1 HOXD4	2.30e-04	20	39	2	1970329
Pubmed	Proteins recruited by SH3 domains of Ruk/CIN85 adaptor identified by LC-MS/MS.	DAB2 LIMCH1 ABL1	2.45e-04	108	39	3	19531213
Pubmed	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.	GTF2F1 ZC3H18 TBRG4 ZNF385A TCOF1 PRRC2B	2.60e-04	807	39	6	22681889
Pubmed	Risk of meningomyelocele mediated by the common 22q11.2 deletion.	SLC7A4 ABL1	3.62e-04	25	39	2	38696583
Pubmed	Differential protein-protein interactions of LRRK1 and LRRK2 indicate roles in distinct cellular signaling pathways.	ABL1 PAK6	3.62e-04	25	39	2	24947832
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	CC2D1A LIMCH1 ABL1 PAK6 WNK1 PI4KB	3.67e-04	861	39	6	36931259
Pubmed	The RNA binding protein MEX3A promotes tumor progression of breast cancer by post-transcriptional regulation of IGFBP4.	ABL1 ARID1A FARP1 PRRC2B	5.15e-04	332	39	4	37433992
Pubmed	Mammalian APE1 controls miRNA processing and its interactome is linked to cancer RNA metabolism.	DAB2 CC2D1A OSBP2 LIMCH1 TBRG4 PI4KB	5.37e-04	925	39	6	28986522
Pubmed	Interaction network of human early embryonic transcription factors.	PRR12 ZFHX4 ARID1A PRRC2B	6.35e-04	351	39	4	38297188
Pubmed	USP1 deubiquitinates Akt to inhibit PI3K-Akt-FoxO signaling in muscle during prolonged starvation.	DAB2 ARID1A	7.96e-04	37	39	2	32133736
Pubmed	Genome-wide association study of d-amphetamine response in healthy volunteers identifies putative associations, including cadherin 13 (CDH13).	ABL1 FARP1	8.40e-04	38	39	2	22952603
Pubmed	Quantitative trait loci affecting the 3D skull shape and size in mouse and prioritization of candidate genes in-silico.	ARID1A TCOF1	8.84e-04	39	39	2	25859222
Pubmed	An inducible CRISPR/Cas9 screen identifies DTX2 as a transcriptional regulator of human telomerase.	DAB2 PRR12 NUP35	1.09e-03	180	39	3	35198878
Interaction	HNF1B interactions	PRR12 ZFHX4 ARID1A TCOF1 PRRC2B NUP35	1.63e-06	190	39	6	int:HNF1B
Cytoband	12p13.2	PRB1 PRB2	6.80e-04	45	39	2	12p13.2
GeneFamily	Proline rich proteins	PRB1 PRB2	2.74e-05	6	25	2	972
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	CC2D1A PCLO	1.12e-03	36	25	2	823
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	OSBP2 FARP1 APBB1IP	2.79e-03	206	25	3	682
Drug	WY-14643; Up 200; 100uM; PC3; HG-U133A	SLC7A4 WNK1 FARP1 PI4KB ACSS3	2.09e-05	197	39	5	464_UP
Drug	Sulfaguanidine [57-67-0]; Down 200; 18.6uM; PC3; HG-U133A	DAB2 CC2D1A LIMCH1 ARID1A PI4KB	2.14e-05	198	39	5	1913_DN
Drug	Piperine [94-62-2]; Up 200; 14uM; MCF7; HT_HG-U133A	DAB2 PAK6 WNK1 NYNRIN PCLO	2.14e-05	198	39	5	4830_UP
Drug	2-bromo-benzoate	LMOD1 PRB1	2.85e-05	5	39	2	CID000006940
Disease	triacylglycerol 56:2 measurement	LIMCH1 ZFHX4	8.35e-05	11	37	2	EFO_0010429
Disease	interleukin 2 receptor antagonist measurement	ZNF469 LIMCH1	8.87e-04	35	37	2	EFO_0008332
Disease	Burkitt Lymphoma	ABL1 ARID1A	9.38e-04	36	37	2	C0006413
Disease	free androgen index	ZNF469 ZFHX4 ARID1A NYNRIN	1.21e-03	374	37	4	EFO_0007005
Disease	Colorectal Carcinoma	DCHS1 PAK6 ARID1A WNK1 TCOF1	1.74e-03	702	37	5	C0009402
Disease	L2 Acute Lymphoblastic Leukemia	ABL1 HOXD4	1.80e-03	50	37	2	C0023453
Disease	depressive symptom measurement, stressful life event measurement	PCLO CNTN6	1.80e-03	50	37	2	EFO_0007006, EFO_0007781
Disease	Childhood Acute Lymphoblastic Leukemia	ABL1 HOXD4	1.95e-03	52	37	2	C0023452
Disease	Precursor Cell Lymphoblastic Leukemia Lymphoma	ABL1 HOXD4	2.67e-03	61	37	2	C1961102
Disease	aspartate aminotransferase to alanine aminotransferase ratio	MSANTD1 ARID1A NYNRIN	3.33e-03	239	37	3	EFO_0010934
Disease	non-melanoma skin carcinoma	ZNF469 ZFHX4 FARP1	4.44e-03	265	37	3	EFO_0009260

Protein segments in the cluster

Peptide	Gene	Start	Entry
PSPPSIPETGQGVTK	ZNF385A	161	Q96PM9
PAQPSTGPKTGTTQP	APBB1IP	451	Q7Z5R6
PPGTAESKPDSQPQK	C17orf78	236	Q8N4C9
SSPGPASPGPLTKQQ	SLC7A4	421	O43246
SQPKIQPPSPAGSGS	ARID1A	1126	O14497
VKSSPNPFVGSPPKG	DAB2	391	P98082
GKLPDSQPPGPSTSQ	MSANTD1	141	Q6ZTZ1
PGAKSVPPKPANTAA	DCHS1	3211	Q96JQ0
SSKPGPPPQSKPNSS	PAK6	276	Q9NQU5
QKNTPPTDSPSKAGP	FETUB	286	Q9UGM5
GLQSPAKAPGPTKTP	PCLO	426	Q9Y6V0
AKAPGPTKTPVQQPG	PCLO	431	Q9Y6V0
PGKTSAQQTGPTKPP	PCLO	456	Q9Y6V0
SAKPPSQQPGSTKPP	PCLO	496	Q9Y6V0
STKPPSQQPGSAKPS	PCLO	526	Q9Y6V0
KPVSQTGSGKPLQPP	PCLO	556	Q9Y6V0
SQPPTSQGPPKSTGQ	PCLO	971	Q9Y6V0
PEKQTPSGPTKPSEG	LMOD1	291	P29536
AGAVAKGSPKPSPQP	LMOD1	501	P29536
QSKVSPPGTATNPNP	KLKP1	66	Q107X0
ASTSGSGPEPKPQPQ	OSBP2	41	Q969R2
SDPKQPPSGTALKQP	HOXD4	116	P09016
QSKPQPPQPSTGSLT	FARP1	461	Q9Y4F1
PQSGSAPTAKAPPKA	CC2D1A	471	Q6P1N0
PAKSPKPSNGAGVPN	ABL1	656	P00519
GTGPSSPPVNVTTKK	CNTN6	886	Q9UQ52
VTTKKTPPSQPPGNV	CNTN3	896	Q9P232
KSQSARSPPGKPQGP	PRB2	231	P02812
AQPTGSQSPPPGSKR	TBRG4	546	Q969Z0
PTPPGQSPNRSISGK	LIMCH1	996	Q9UPQ0
SPAGPKTPKAQAGPA	NYNRIN	636	Q9P2P1
PPIKTLGTPTQPGST	NUP35	266	Q8NFH5
STPQPPSGKTTPNSG	GTF2F1	436	P35269
LQAKPTSSPAKGPPQ	TCOF1	576	Q13428
TSSPAKGPPQKAGPV	TCOF1	581	Q13428
KNPVSAGGSSAPPPK	PRR12	1681	Q9ULL5
LKPTSEPTSGPPGNN	PI4KB	11	Q9UBF8
NSKTPPPGQAGKSVP	ACSS3	466	Q9H6R3
ASNQGPTTPRKGPPK	PDE6H	11	Q13956
DKSQSPRSPPGKPQG	PRB1	146	P04280
GDKSQSPRSPPGKPQ	PRB1	206	P04280
QGDKSRSPQSPPGKP	PRB1	266	P04280
KSQSARSPPGKPQGP	PRB1	331	P04280
EKPKQSDPSPPSQGT	ZFHX4	2366	Q86UP3
PPGPSSNPVSNGKET	NABP2	191	Q9BQ15
SKQNVPSGGPVPSPQ	PRRC2B	2141	Q5JSZ5
KGSGSRPPTPKSSPQ	VRK3	96	Q8IV63
PKAKPGPSSQGSGSP	ZNF469	3696	Q96JG9
TTSGVKPGTAPSKPP	WNK1	1741	Q9H4A3
TQPPKSAKPPAGGKS	ZC3H18	776	Q86VM9