Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyCellularComponentintermediate filament

SCYGR6 SCYGR4 SCYGR9 SCYGR2 SCYGR8 SCYGR7 SCYGR5

1.89e-12227107GO:0005882
GeneOntologyCellularComponentintermediate filament cytoskeleton

SCYGR6 SCYGR4 SCYGR9 SCYGR2 SCYGR8 SCYGR7 SCYGR5

5.35e-12263107GO:0045111
GeneOntologyCellularComponentpolymeric cytoskeletal fiber

SCYGR6 SCYGR4 SCYGR9 SCYGR2 SCYGR8 SCYGR7 SCYGR5

2.85e-08899107GO:0099513
GeneOntologyCellularComponentsupramolecular fiber

SCYGR6 SCYGR4 SCYGR9 SCYGR2 SCYGR8 SCYGR7 SCYGR5

1.84e-071179107GO:0099512
GeneOntologyCellularComponentsupramolecular polymer

SCYGR6 SCYGR4 SCYGR9 SCYGR2 SCYGR8 SCYGR7 SCYGR5

1.93e-071187107GO:0099081
DomainL6_membrane

TM4SF4 TM4SF5

2.58e-07632PF05805
DomainL6_membrane

TM4SF4 TM4SF5

2.58e-07632IPR008661
Pubmed

Molecular evolution of the keratin associated protein gene family in mammals, role in the evolution of mammalian hair.

SCYGR6 SCYGR4 SCYGR9 SCYGR2 SCYGR8 SCYGR7 SCYGR5

1.06e-176910718721477
Pubmed

The L6 membrane proteins--a new four-transmembrane superfamily.

TM4SF4 TM4SF5

2.23e-07310210975581
Pubmed

Differential regulation of cellular functions by the C-termini of transmembrane 4 L six family proteins in 2- or 3-dimensional environment.

TM4SF4 TM4SF5

2.23e-07310228129652
Pubmed

The L6 domain tetraspanin Tm4sf4 regulates endocrine pancreas differentiation and directed cell migration.

TM4SF4 TM4SF5

4.90e-061210221750032
Pubmed

Complexes of tetraspanins with integrins: more than meets the eye.

TM4SF4 TM4SF5

2.05e-052410211739647
Pubmed

Decreased expression levels of Ifi genes is associated to the increased resistance to spontaneous arthritis disease in mice deficiency of IL-1RA.

TM4SF4 TM4SF5

1.41e-0319810227480124
CytobandEnsembl 112 genes in cytogenetic band chr2q36

SCYGR6 SCYGR4 SCYGR9 SCYGR2 SCYGR8 SCYGR7 SCYGR5

6.92e-1885107chr2q36
CoexpressionMURARO_PANCREAS_EPSILON_CELL

TM4SF4 TM4SF5

8.25e-064432M39172
CoexpressionBUSSLINGER_GASTRIC_G_CELLS

TM4SF4 TM4SF5

4.14e-059832M40018
CoexpressionBUSSLINGER_DUODENAL_LATE_IMMATURE_ENTEROCYTES

TM4SF4 TM4SF5

1.35e-0417732M40028
CoexpressionGSE19825_NAIVE_VS_IL2RAHIGH_DAY3_EFF_CD8_TCELL_UP

TM4SF4 ITGBL1

1.73e-0420032M4299
CoexpressionBUSSLINGER_DUODENAL_MATURE_ENTEROCYTES

TM4SF4 TM4SF5

2.90e-0425932M40029
CoexpressionCHEN_METABOLIC_SYNDROM_NETWORK

TM4SF4 ITGBL1

6.52e-03124232M1920
CoexpressionCHEN_METABOLIC_SYNDROM_NETWORK

TM4SF4 ITGBL1

7.30e-03131632MM1052
CoexpressionAtlasgallbladder

TM4SF4 ITGBL1

1.44e-0414832gallbladder
CoexpressionAtlasduodenum

TM4SF4 TM4SF5

6.77e-0432132duodenum
CoexpressionAtlassmall intestine

TM4SF4 TM4SF5

7.54e-0433932small intestine
ToppCell5'-GW_trimst-1.5-SmallIntestine-Epithelial-neuro-epithelial-EECs|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TM4SF4 TM4SF5 SCYGR2

2.07e-06177735bccc7a74019eae8afd977a9c9134d884857ac27
ToppCellmetastatic_Brain-T/NK_cells-CD8_low_T|T/NK_cells / Location, Cell class and cell subclass

TM4SF5 ITGBL1

1.94e-0413872b2ab273f3e62f169b3b9cb82342e6617af99f582
ToppCellTCGA-Breast-Metastatic-Breast_Carcinoma-Infiltrating_Ductal_Carcinoma|TCGA-Breast / Sample_Type by Project: Shred V9

TM4SF4 TM4SF5

2.26e-04149722e9b898f3df22f8e872f2c278eff454c39e55b3b
ToppCellTCGA-Head_and_Esophagus-Primary_Tumor-Esophageal_Carcinoma-Adenocarcinoma|TCGA-Head_and_Esophagus / Sample_Type by Project: Shred V9

TM4SF4 TM4SF5

2.26e-041497292a8931a51db619fb5f0638d319c02e7838f6559
ToppCellTCGA-Breast-Metastatic|TCGA-Breast / Sample_Type by Project: Shred V9

TM4SF4 TM4SF5

2.26e-0414972144ac2c458209ce510674bc2f83eb4c8e4d3c953
ToppCellTCGA-Breast-Metastatic-Breast_Carcinoma|TCGA-Breast / Sample_Type by Project: Shred V9

TM4SF4 TM4SF5

2.26e-0414972c7dc495141cd921b6b6f291a68851b7b807d0d0a
ToppCellTCGA-Lung-Primary_Tumor-Lung_Carcinoma-Lung_Mucinous_Lepidic_Adenocarcinoma-7|TCGA-Lung / Sample_Type by Project: Shred V9

TM4SF4 TM4SF5

2.32e-04151723dfa1d89975ffaa45b26833538244153d50c60a7
ToppCellTCGA-Lung-Primary_Tumor-Lung_Carcinoma-Lung_Mucinous_Lepidic_Adenocarcinoma|TCGA-Lung / Sample_Type by Project: Shred V9

TM4SF4 TM4SF5

2.32e-041517260bb6de5d9b13402bc18cb6d5e51078326dff8e2
ToppCellTCGA-Cervix-Primary_Tumor-Endocervical_Adenocarcinoma-Mucinous_Adenocarcinoma-7|TCGA-Cervix / Sample_Type by Project: Shred V9

TM4SF4 TM4SF5

2.58e-041597275a82bbabd97b168dbf1c3f43a9bdad48ce18c78
ToppCell5'-GW_trimst-2-SmallIntestine-Epithelial-neuro-epithelial-EECs|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TM4SF4 TM4SF5

2.67e-04162729f568836199a05f696294caac1ea3fa413984423
ToppCell5'-GW_trimst-2-SmallIntestine-Epithelial-neuro-epithelial-K_cells_(GIP+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TM4SF4 TM4SF5

2.81e-0416672afba41e15478053f11815acf568d29187de75492
ToppCell3'-GW_trimst-2-SmallIntestine-Epithelial-neuro-epithelial-I_cells_(CCK+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TM4SF4 TM4SF5

2.88e-0416872f3164a85e5630ee8a745c6dba298e1f94ba4d5b8
ToppCellTCGA-Pancreas|World / Sample_Type by Project: Shred V9

TM4SF4 ITGBL1

2.88e-0416872279d5fcf9bd3f56ab560e37eed6fb3bd57dd93de
ToppCell3'-GW_trimst-2-SmallIntestine-Epithelial-neuro-epithelial-D_cells_(SST+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TM4SF4 TM4SF5

2.98e-0417172fa5cc720bd0045d0307439be547b41d56def5b43
ToppCell5'-GW_trimst-1.5-SmallIntestine-Epithelial-neuro-epithelial-I_cells_(CCK+)|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TM4SF4 TM4SF5

3.01e-04172722651dece87c3e3d2d6370f5274ebae357474b825
ToppCell5'-Adult-SmallIntestine-Epithelial-neuro-epithelial|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TM4SF4 TM4SF5

3.05e-041737230fa8c14c8a1f546f380132c0c28a61e6a2f9fc4
ToppCell3'-GW_trimst-1.5-SmallIntestine-Epithelial-neuro-epithelial|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TM4SF4 TM4SF5

3.05e-041737246ed379571385684145b5cb6dd4ae340ac546e64
ToppCell5'-GW_trimst-2-SmallIntestine-Epithelial-mature_enterocytic-Paneth|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TM4SF4 TM4SF5

3.12e-0417572bffa623511ceb0b9bf76d87f9a10cfadfe0e940f
ToppCell3'-GW_trimst-2-SmallIntestine-Epithelial-mature_enterocytic-Paneth|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TM4SF4 TM4SF5

3.12e-041757224651f95540ea2c8f3720aa943cbdd15661ee3fa
ToppCell5'-GW_trimst-2-SmallIntestine-Epithelial-neuro-epithelial-I_cells_(CCK+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TM4SF4 TM4SF5

3.12e-0417572c031da47ca63d1133e13530cbf779df9435e22cb
ToppCell3'-GW_trimst-2-SmallIntestine-Epithelial-neuro-epithelial-K_cells_(GIP+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TM4SF4 TM4SF5

3.15e-0417672d54543510c804474c5c32e007cd699e75fc5aaba
ToppCell5'-GW_trimst-1.5-SmallIntestine-Epithelial-neuro-epithelial-EC_cells_(TAC1+)|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TM4SF4 TM4SF5

3.15e-041767271f96cace3f20fbef975037f4deff9b82b0282a1
ToppCell3'-GW_trimst-1.5-SmallIntestine-Epithelial-neuro-epithelial-K_cells_(GIP+)|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TM4SF4 TM4SF5

3.19e-041777243dce527392f3b8364bb6a55268ce9d6518d3a29
ToppCell3'_v3-Lung-Myeloid_Mac-Erythrophagocytic_macrophages|Lung / Manually curated celltypes from each tissue

TM4SF4 TM4SF5

3.23e-0417872b63cee443cc1b7416112bf610d7c9d41e4fa37ed
ToppCell5'-GW_trimst-2-SmallIntestine-Epithelial-neuro-epithelial-EC_cells_(TAC1+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TM4SF4 TM4SF5

3.30e-04180726b1606238417490e0d9930870a7827419d1c3737
ToppCell5'-Adult-SmallIntestine-Epithelial-neuro-epithelial-I_cells_(CCK+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TM4SF4 TM4SF5

3.37e-041827227a27a3eaeacb087c9601d5bb1c9e57cdfcd9d77
ToppCell3'-GW_trimst-2-SmallIntestine-Epithelial-neuro-epithelial-EC_cells_(TAC1+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TM4SF4 TM4SF5

3.48e-0418572eb78614c4acf8d2ce7874d7e51e16997b76127ef
ToppCell15-Distal-RBC-RBC|Distal / Age, Tissue, Lineage and Cell class

TM4SF4 TM4SF5

3.60e-04188722534684e4932c1255c24a26ca2277ac7af0a118b
ToppCell5'-GW_trimst-1.5-SmallIntestine-Epithelial-neuro-epithelial|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TM4SF4 TM4SF5

3.60e-0418872b6aad90fa77fbaf80487a55415aa6c245f2d1f7e
ToppCell15-Distal-RBC|Distal / Age, Tissue, Lineage and Cell class

TM4SF4 TM4SF5

3.60e-0418872c68ccb1c5c21d13ddac09b16e7d466f0530bbda5
ToppCell5'-GW_trimst-2-SmallIntestine-Epithelial-neuro-epithelial|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TM4SF4 TM4SF5

3.75e-04192725692bd57093852d442400383850f416c497dcc7d
ToppCell5'-GW_trimst-2-SmallIntestine-Epithelial-Tuft-related-BEST4+_epithelial|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TM4SF4 TM4SF5

3.75e-04192724a2c82e7af700ae6f04742027877768b151f5d81
ToppCell3'-GW_trimst-2-SmallIntestine-Epithelial-neuro-epithelial|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TM4SF4 TM4SF5

3.75e-04192720b506fb5bca54a50949932293c6f86d974a3acdd
ToppCell5'-GW_trimst-2-SmallIntestine-Epithelial-goblet|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TM4SF4 TM4SF5

3.79e-0419372402aad2f9e789ad1f2e1536cdc9ce61de7625427
ToppCell5'-GW_trimst-2-SmallIntestine-Epithelial-goblet-Goblet_cell|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TM4SF4 TM4SF5

3.79e-04193727ee3b1ef5c455f321b4e154ae62c69543fe9b30e
ToppCell5'-GW_trimst-2-SmallIntestine-Epithelial-Tuft-related|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TM4SF4 TM4SF5

3.83e-041947264e07de047969017628a164b254852c87d33844c
ToppCell3'-GW_trimst-2-SmallIntestine-Epithelial-goblet|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TM4SF4 TM4SF5

3.87e-0419572e1fb987f13482d1fce0428413244be3621136424
ToppCell5'-Adult-SmallIntestine-Epithelial-Tuft-related|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TM4SF4 TM4SF5

3.87e-041957223ab7e2a419377c05bab0e92a2457afbcd3d9e07
ToppCell5'-Adult-SmallIntestine-Epithelial-Tuft-related-BEST4+_epithelial|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TM4SF4 TM4SF5

3.87e-0419572e87b11e3242fdbed2e7f383e6876ec375af32bd4
ToppCell3'-GW_trimst-2-SmallIntestine-Epithelial-goblet-Goblet_cell|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TM4SF4 TM4SF5

3.87e-0419572482a2e7db72f0da285bb658943dd668777519734
ToppCell5'-Adult-SmallIntestine-Epithelial-mature_enterocytic-Enterocyte|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TM4SF4 TM4SF5

3.99e-04198726e6af8fad09f8e48b3f2ce463d5773b6a69864d1
ToppCellproximal-Epithelial-Neuroendocrine|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

TM4SF4 TM4SF5

3.99e-04198725dea6078488d584513c0bdbf5bba54877310b54a
ToppCellproximal-Epithelial-Neuroendocrine-3|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

TM4SF4 TM4SF5

3.99e-041987200ccf3020667cf2130bc354b441b65c0b1b0e862
ToppCell3'-GW_trimst-2-SmallIntestine|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TM4SF4 TM4SF5

3.99e-0419872cc162ba4b3b8dec667a8cffd3411965f3f856f8c
ToppCellEnterocyte-C_01|Enterocyte / shred on cell type and cluster

TM4SF4 TM4SF5

3.99e-04198724e2c30d6fd1d59db98a52bfcc3206b4c4ac5abe2
ToppCell5'-Adult-SmallIntestine-Epithelial|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TM4SF4 TM4SF5

3.99e-04198728d629492d2199de8e036c19e9dacceb9c9e721a0
ToppCellproximal-3-Epithelial-Neuroendocrine|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

TM4SF4 TM4SF5

3.99e-0419872a6bc043faf68468d46bac441cf7447c236c7bae4
ToppCell5'-Adult-SmallIntestine|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TM4SF4 TM4SF5

4.03e-0419972a5fffe381be1ba7d192b68d1d3937ce47663658e
ToppCell5'-Adult-SmallIntestine-Epithelial-mature_enterocytic|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TM4SF4 TM4SF5

4.03e-041997201c2721bc82cd672e9477029b4a7ecc77e2f1b00
ComputationalLiver genes - metabolism and xenobiotics.

TM4SF4 TM4SF5 ITGBL1

1.43e-0456333MODULE_23
DrugLithocholic acid [434-13-9]; Down 200; 10.6uM; MCF7; HT_HG-U133A

TM4SF4 TM4SF5

2.18e-04195324373_DN
DrugSulfadoxine [2447-57-6]; Up 200; 12.8uM; MCF7; HT_HG-U133A

TM4SF4 TM4SF5

2.18e-04195323547_UP
DrugFuraltadone hydrochloride [3759-92-0]; Up 200; 11uM; PC3; HT_HG-U133A

TM4SF4 TM4SF5

2.18e-04195324313_UP
DrugEthosuximide [77-67-8]; Up 200; 28.4uM; MCF7; HT_HG-U133A

TM4SF4 ITGBL1

2.20e-04196322280_UP
DrugApigenin [520-36-5]; Up 200; 14.8uM; PC3; HT_HG-U133A

TM4SF4 TM4SF5

2.20e-04196324578_UP
DrugClemizole hydrochloride [1163-36-6]; Up 200; 11uM; MCF7; HT_HG-U133A

TM4SF4 TM4SF5

2.20e-04196322301_UP
DrugNapelline [5008-52-6]; Up 200; 11.2uM; MCF7; HT_HG-U133A

TM4SF5 ITGBL1

2.20e-04196326084_UP
DrugLomefloxacin hydrochloride [98079-52-8]; Up 200; 10.4uM; MCF7; HT_HG-U133A

TM4SF4 TM4SF5

2.20e-04196322310_UP
DrugN-Acetyl-DL-homocysteine Thiolactone [1195-16-0]; Down 200; 25.2uM; MCF7; HT_HG-U133A

TM4SF4 TM4SF5

2.22e-04197323930_DN
DrugDiphemanil methylsulfate [62-97-5]; Up 200; 10.2uM; MCF7; HT_HG-U133A

TM4SF4 TM4SF5

2.22e-04197324416_UP
DrugPiperacillin sodium salt [59703-84-3]; Down 200; 7.4uM; MCF7; HT_HG-U133A

TM4SF4 TM4SF5

2.22e-04197323939_DN
DrugAcyclovir [59277-89-3]; Up 200; 17.8uM; MCF7; HT_HG-U133A

TM4SF4 TM4SF5

2.22e-04197325643_UP
DrugN-Acetyl-DL-homocysteine Thiolactone [1195-16-0]; Up 200; 25.2uM; HL60; HT_HG-U133A

TM4SF5 ITGBL1

2.24e-04198322176_UP
DrugSolasodine [126-17-0]; Up 200; 9.6uM; MCF7; HT_HG-U133A

TM4SF4 TM4SF5

2.24e-04198326025_UP
DrugPHA-00851261E [724719-49-7]; Up 200; 1uM; PC3; HT_HG-U133A

TM4SF4 TM4SF5

2.24e-04198324333_UP
DrugParoxetine maleate [64006-44-6]; Down 200; 1uM; MCF7; HT_HG-U133A

TM4SF4 TM4SF5

2.24e-04198324378_DN
DrugMetoclopramide monohydrochloride [7232-21-5]; Up 200; 11.8uM; MCF7; HT_HG-U133A

TM4SF4 TM4SF5

2.27e-04199322315_UP
DrugParoxetine maleate [64006-44-6]; Up 200; 1uM; PC3; HT_HG-U133A

TM4SF4 TM4SF5

2.27e-04199323821_UP
DrugFurazolidone [67-45-8]; Up 200; 17.8uM; MCF7; HT_HG-U133A

TM4SF4 TM4SF5

2.27e-04199324178_UP
DrugAdamantamine fumarate [80789-67-9]; Up 200; 9.6uM; MCF7; HT_HG-U133A

TM4SF4 TM4SF5

2.27e-04199323280_UP
DrugTropicamide [1508-75-4]; Up 200; 14uM; MCF7; HT_HG-U133A

TM4SF4 TM4SF5

2.27e-04199322309_UP
DrugMethylcholanthrene

TM4SF4 ITGBL1

5.99e-03103432ctd:D008748
Diseaseserum gamma-glutamyl transferase measurement

TM4SF4 TM4SF5

1.32e-0291462EFO_0004532

Protein segments in the cluster

PeptideGeneStartEntry
GHGKCYCGNCYCKAG

ITGBL1

196

O95965
TCGSCGCGCGKGCCQ

SCYGR7

71

A0A286YF01
GCGCGKGCCQQKGCC

SCYGR7

76

A0A286YF01
CGCGCGCGKGCCQQK

SCYGR6

76

A0A286YF77
GCGKGCCQQKGCCQQ

SCYGR6

81

A0A286YF77
CGCGYGKGCCQQKGC

SCYGR8

81

A0A286YFG1
CGCGCGKGCCQQKSC

SCYGR9

71

P0DSO2
CGSCGCGYGKGCCQQ

SCYGR4

81

A0A286YEV6
CGYGKGCCQQKCCCQ

SCYGR4

86

A0A286YEV6
CGCGKGCCQQKGCCQ

SCYGR5

66

A0A286YF46
GGKGCCGAGCCGNRC

TM4SF5

71

O14894
CHSCGCGCGKGCCQQ

SCYGR2

96

A0A286YFB4
NNDCCGCCGNEGCGK

TM4SF4

71

P48230