Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctioncytoskeletal motor activity

KIF18A KIF6 MYO7A STARD9 DYNC1H1

3.82e-05118645GO:0003774
GeneOntologyMolecularFunctionmicrotubule motor activity

KIF18A KIF6 STARD9 DYNC1H1

7.51e-0570644GO:0003777
GeneOntologyMolecularFunctionRNA polymerase I general transcription initiation factor activity

UBTFL6 TAF1L

3.59e-049642GO:0001181
GeneOntologyMolecularFunctionprotein serine/threonine kinase activity

TRPM7 CSNK1G1 LMTK3 MAP3K21 TAF1L CDK10 CASK

5.48e-04446647GO:0004674
GeneOntologyMolecularFunctionprotein kinase activity

TRPM7 GUCY2F CSNK1G1 LMTK3 MAP3K21 TAF1L CDK10 CASK

6.38e-04600648GO:0004672
GeneOntologyMolecularFunctionprotein serine kinase activity

TRPM7 CSNK1G1 LMTK3 MAP3K21 CDK10 CASK

1.07e-03363646GO:0106310
GeneOntologyMolecularFunctionnucleoside-triphosphatase regulator activity

ARHGAP4 SBF1 DOCK11 SRGAP3 SRGAP1 ITSN2 NPRL3

1.16e-03507647GO:0060589
GeneOntologyMolecularFunctionGTPase regulator activity

ARHGAP4 SBF1 DOCK11 SRGAP3 SRGAP1 ITSN2 NPRL3

1.16e-03507647GO:0030695
DomainSH3

ARHGAP4 MYO7A SRGAP3 SRGAP1 ITSN2 PPP1R13L MAP3K21 CASK

5.56e-07216628SM00326
DomainSH3

ARHGAP4 MYO7A SRGAP3 SRGAP1 ITSN2 PPP1R13L MAP3K21 CASK

5.56e-07216628PS50002
DomainSH3_domain

ARHGAP4 MYO7A SRGAP3 SRGAP1 ITSN2 PPP1R13L MAP3K21 CASK

6.39e-07220628IPR001452
DomainSH3_1

ARHGAP4 SRGAP3 SRGAP1 ITSN2 PPP1R13L MAP3K21

1.71e-05164626PF00018
DomainFCH

ARHGAP4 SRGAP3 SRGAP1

5.13e-0522623PF00611
DomainFCH

ARHGAP4 SRGAP3 SRGAP1

5.13e-0522623SM00055
DomainFCH_dom

ARHGAP4 SRGAP3 SRGAP1

5.88e-0523623IPR001060
DomainF_BAR

ARHGAP4 SRGAP3 SRGAP1

7.61e-0525623IPR031160
DomainF_BAR

ARHGAP4 SRGAP3 SRGAP1

7.61e-0525623PS51741
DomainKinesin_motor_CS

KIF18A KIF6 STARD9

3.39e-0441623IPR019821
DomainKINESIN_MOTOR_1

KIF18A KIF6 STARD9

4.19e-0444623PS00411
Domain-

KIF18A KIF6 STARD9

4.19e-04446233.40.850.10
DomainKinesin_motor_dom

KIF18A KIF6 STARD9

4.19e-0444623IPR001752
DomainKinesin

KIF18A KIF6 STARD9

4.19e-0444623PF00225
DomainKINESIN_MOTOR_2

KIF18A KIF6 STARD9

4.19e-0444623PS50067
DomainKISc

KIF18A KIF6 STARD9

4.19e-0444623SM00129
DomainSpectrin_alpha_SH3

SRGAP3 ITSN2

1.11e-0315622IPR013315
DomainRhoGAP

ARHGAP4 SRGAP3 SRGAP1

1.15e-0362623SM00324
DomainRhoGAP

ARHGAP4 SRGAP3 SRGAP1

1.20e-0363623PF00620
DomainRHOGAP

ARHGAP4 SRGAP3 SRGAP1

1.26e-0364623PS50238
DomainRhoGAP_dom

ARHGAP4 SRGAP3 SRGAP1

1.26e-0364623IPR000198
Domain-

ARHGAP4 SRGAP3 SRGAP1

1.26e-03646231.10.555.10
DomainSH3_9

ITSN2 PPP1R13L MAP3K21

2.22e-0378623PF14604
DomainRho_GTPase_activation_prot

ARHGAP4 SRGAP3 SRGAP1

3.13e-0388623IPR008936
DomainENTH_VHS

GGA2 U2SURP

4.16e-0329622IPR008942
Pubmed

FNBP2 gene on human chromosome 1q32.1 encodes ARHGAP family protein with FCH, FBH, RhoGAP and SH3 domains.

ARHGAP4 SRGAP3 SRGAP1

1.18e-07664312736724
Pubmed

Slit-Robo GTPase-activating proteins are differentially expressed in murine dorsal root ganglia: modulation by peripheral nerve injury.

SRGAP3 SRGAP1

3.33e-06264222271578
Pubmed

Jade-1S phosphorylation induced by CK1α contributes to cell cycle progression.

RPL23A RSL1D1 POGZ DNTTIP2

3.56e-065664426919559
Pubmed

The WRP component of the WAVE-1 complex attenuates Rac-mediated signalling.

ARHGAP4 SRGAP3

9.99e-06364212447388
Pubmed

Expression of the heparan sulfate 6-O-endosulfatases, Sulf1 and Sulf2, in the avian and mammalian inner ear suggests a role for sulfation during inner ear development.

MYO7A SULF1

9.99e-06364225370455
Pubmed

Dynamic expression of the Slit-Robo GTPase activating protein genes during development of the murine nervous system.

SRGAP3 SRGAP1

9.99e-06364219137586
Pubmed

Candidate Oncogenes, ARHGAP4, NOS3, and OR51B5, for the Development of Scirrhous-type Gastric Cancer.

ARHGAP4 NOS3

9.99e-06364236288877
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

C2CD3 SBF1 TRPM7 DOCK11 STARD9 SRGAP1 PLEKHA1 TRIM68 MAP3K21

2.73e-0586164936931259
Pubmed

All kinesin superfamily protein, KIF, genes in mouse and human.

KIF18A KIF6 STARD9

4.42e-053764311416179
Pubmed

Monoubiquitylation of GGA3 by hVPS18 regulates its ubiquitin-binding ability.

VPS18 GGA2

4.98e-05664216996030
Pubmed

SRGAP1 Controls Small Rho GTPases To Regulate Podocyte Foot Process Maintenance.

SRGAP3 SRGAP1

4.98e-05664233514561
Pubmed

Signal transduction in neuronal migration: roles of GTPase activating proteins and the small GTPase Cdc42 in the Slit-Robo pathway.

SRGAP3 SRGAP1

4.98e-05664211672528
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

ARHGAP4 GGA2 SBF1 SULF1 ANKIB1 POGZ FEM1C

5.32e-0552964714621295
Pubmed

Evidence for a role of srGAP3 in the positioning of commissural axons within the ventrolateral funiculus of the mouse spinal cord.

SRGAP3 SRGAP1

6.96e-05764221655271
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

SRGAP3 STARD9 ZFR2 ITSN2 POGZ DYNC1H1

1.05e-0440764612693553
Pubmed

Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening.

SRGAP3 SRGAP1 ITSN2

1.10e-045064319807924
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

TRPM7 EHMT2 RSL1D1 SULF1 PDZD8 POGZ TRIM68 ZNF439 DYNC1H1 CASK

1.13e-041285641035914814
Pubmed

Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.

FANCD2 KIF18A C2CD3 SBF1 PTPRR PDZD8 PLEKHA1 PPP1R13L CASK

1.24e-04104964927880917
Pubmed

Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.

RPL23A SBF1 DOCK11 RSL1D1 ZBTB10 DNTTIP2

1.60e-0444064634244565
Pubmed

SHLD2/FAM35A co-operates with REV7 to coordinate DNA double-strand break repair pathway choice.

FANCD2 EHMT2 POGZ DYNC1H1

1.73e-0415064430154076
Pubmed

Eml1 loss impairs apical progenitor spindle length and soma shape in the developing cerebral cortex.

KIF18A DYNC1H1

1.81e-041164229229923
Pubmed

BioID reveals an ATG9A interaction with ATG13-ATG101 in the degradation of p62/SQSTM1-ubiquitin clusters.

VPS18 GGA2 ITSN2 PLEKHA1 MAP3K21

1.83e-0428564534369648
Pubmed

Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.

RPL23A SBF1 RSL1D1 U2SURP POGZ DYNC1H1 DNTTIP2

1.96e-0465364722586326
Pubmed

Systems analysis of RhoGEF and RhoGAP regulatory proteins reveals spatially organized RAC1 signalling from integrin adhesions.

ARHGAP4 DOCK11 SRGAP3 SRGAP1 ITSN2 PPP1R13L PNKD CASK

2.70e-0491664832203420
Pubmed

Sequence and expression of murine type I hair keratins mHa2 and mHa3.

KIF6 STARD9

2.99e-04146427514534
Pubmed

Activity-dependent neuroprotective protein recruits HP1 and CHD4 to control lineage-specifying genes.

RPL23A EHMT2 POGZ

3.51e-047464329795351
Pubmed

New interaction partners for Nek4.1 and Nek4.2 isoforms: from the DNA damage response to RNA splicing.

RPL23A VPS18 KCNH7 MYO7A STARD9 U2SURP

3.64e-0451364625798074
Pubmed

MEKK4 Signaling Regulates Sensory Cell Development and Function in the Mouse Inner Ear.

MYO7A NPRL3

3.93e-041664226818521
Pubmed

C2cd3 is required for cilia formation and Hedgehog signaling in mouse.

C2CD3 NODAL

5.00e-041864219004860
Pubmed

A mutation in the Srrm4 gene causes alternative splicing defects and deafness in the Bronx waltzer mouse.

KCNH7 MYO7A CASK

5.27e-048564323055939
Pubmed

Ubiquitin-Independent Disassembly by a p97 AAA-ATPase Complex Drives PP1 Holoenzyme Formation.

RPL23A KIF18A RSL1D1 STARD9 CASK

5.41e-0436164530344098
Pubmed

Large-Scale Functional Assessment of Genes Involved in Rare Diseases with Intellectual Disabilities Unravels Unique Developmental and Behaviour Profiles in Mouse Models.

EHMT2 DYNC1H1

6.20e-042064236551904
Pubmed

USP53 plays an antitumor role in hepatocellular carcinoma through deubiquitination of cytochrome c.

U2SURP DYNC1H1 DNTTIP2

6.23e-049064335654790
Pubmed

CAMK2D serves as a molecular scaffold for RNF8-MAD2 complex to induce mitotic checkpoint in glioma.

ZBTB10 MAD2L1BP CASK

7.07e-049464337468549
Pubmed

GRWD1 regulates ribosomal protein L23 levels via the ubiquitin-proteasome system.

RPL23A RSL1D1 U2SURP DYNC1H1

7.48e-0422164429991511
Pubmed

Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.

RPL23A SBF1 RSL1D1 U2SURP ZBTB10 ANKIB1 POGZ DYNC1H1 DNTTIP2

7.97e-04135364929467282
Pubmed

The receptor guanylyl cyclase Npr2 is essential for sensory axon bifurcation within the spinal cord.

GUCY2F NOS3

8.23e-042364217954614
Pubmed

Sequential genome-wide CRISPR-Cas9 screens identify genes regulating cell-surface expression of tetraspanins.

KIF6 VPS18 SPATA6L U2SURP PLEKHA1 MAD2L1BP DNTTIP2

8.31e-0483264736724073
Pubmed

FBW7 suppresses ovarian cancer development by targeting the N6-methyladenosine binding protein YTHDF2.

RPL23A EHMT2 RSL1D1 SRGAP1 POGZ DYNC1H1

8.33e-0460164633658012
Pubmed

NuRD subunit CHD4 regulates super-enhancer accessibility in rhabdomyosarcoma and represents a general tumor dependency.

EHMT2 RSL1D1 POGZ

9.22e-0410364332744500
Pubmed

Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

GGA2 SULF1 ZFR2

9.48e-0410464310470851
Pubmed

Identification and classification of 16 new kinesin superfamily (KIF) proteins in mouse genome.

KIF6 STARD9

9.73e-04256429275178
Pubmed

Identification of multi-SH3 domain-containing protein interactome in pancreatic cancer: a yeast two-hybrid approach.

ITSN2 PLEKHA1 POGZ

1.00e-0310664318654987
Pubmed

Interactome mapping suggests new mechanistic details underlying Alzheimer's disease.

ITSN2 NOS3 DYNC1H1

1.14e-0311164321163940
Pubmed

Systematic analysis of human protein complexes identifies chromosome segregation proteins.

EHMT2 RSL1D1 U2SURP ITSN2 POGZ PNKD DYNC1H1 MAD2L1BP

1.23e-03115564820360068
Pubmed

USP7 Regulates Cytokinesis through FBXO38 and KIF20B.

KIF18A EHMT2 ZBTB10

1.30e-0311664330804394
Pubmed

Defining the Protein-Protein Interaction Network of the Human Protein Tyrosine Phosphatase Family.

FANCD2 SBF1 DOCK11 PTPRR ACP5 PNKD MAD2L1BP

1.59e-0393164727432908
Pubmed

The endolysosomal adaptor PLEKHM1 is a direct target for both mTOR and MAPK pathways.

VPS18 NPRL3

1.70e-033364233452816
Pubmed

Dopaminergic control of autophagic-lysosomal function implicates Lmx1b in Parkinson's disease.

VPS18 DYNC1H1

1.80e-033464225915474
Pubmed

Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics.

RPL23A DOCK11 RSL1D1 LMTK3 CASK

1.83e-0347564531040226
Cytoband5q23.3

SLC27A6 CHSY3

1.72e-04146425q23.3
GeneFamilyRho GTPase activating proteins|F-BAR domain containing

ARHGAP4 SRGAP3 SRGAP1

2.81e-05234731288
GeneFamilyKinesins|Pleckstrin homology domain containing

KIF18A KIF6 STARD9

2.31e-0446473622
GeneFamilyRho GTPase activating proteins|BCH domain containing

ARHGAP4 SRGAP3 SRGAP1

2.96e-0450473721
GeneFamilyAnkyrin repeat domain containing

EHMT2 ANKIB1 PPP1R13L FEM1C

3.56e-03242474403
GeneFamilyPleckstrin homology domain containing|Rho guanine nucleotide exchange factors|C2 domain containing

C2CD3 ITSN2

3.94e-0336472823
Diseaseepilepsy (implicated_via_orthology)

KCNH7 SBF1 NOS3 DYNC1H1

4.41e-04163644DOID:1826 (implicated_via_orthology)
Diseasepolycystic kidney disease (biomarker_via_orthology)

PLA2G4A NOS3

7.73e-0419642DOID:0080322 (biomarker_via_orthology)
DiseaseNeurodevelopmental Disorders

SRGAP3 POGZ CASK

1.10e-0393643C1535926
Diseaselissencephaly (implicated_via_orthology)

NOS3 DYNC1H1

1.57e-0327642DOID:0050453 (implicated_via_orthology)
DiseaseSevere Congenital Microcephaly

DYNC1H1 CASK

2.07e-0331642C3853041
DiseaseAmyotrophic Lateral Sclerosis, Guam Form

TRPM7 PLA2G4A

2.07e-0331642C0543859

Protein segments in the cluster

PeptideGeneStartEntry
QKVNRPYLRTPRHKI

ANKIB1

696

Q9P2G1
KLRFHPRQLYLSVKQ

EHMT2

646

Q96KQ7
HPRVRKSPENFQYLR

NKX2-6

31

A6NCS4
PQPTRLKYRQKFNTL

ITSN2

241

Q9NZM3
RFLKLHPRGKNNFSP

FEM1C

471

Q96JP0
KNTLITKHPDRFAYP

CASK

756

O14936
FRPKLNYRVPSRGHK

MAD2L1BP

226

Q15013
QTPRINKFTILHYSP

KCNH7

391

Q9NS40
KNQHIPYRNSKLTRL

KIF18A

301

Q8NI77
PIKSRAPQLHLEYRF

CSNK1G1

76

Q9HCP0
NKSVHFPLRSKYNRL

KIAA1109

2076

Q2LD37
QQHVKLARPRLKLPY

LMTK3

366

Q96Q04
QKKLISAPFLFYPQR

LGALS12

271

Q96DT0
RKHTLPNYKIRFKPF

PDZD8

281

Q8NEN9
KLLFRYPFQRSQEHP

NPRL3

21

Q12980
RVKPPVRKHQQGIYS

KIF6

11

Q6ZMV9
YKNSPKPARHVREQL

LHX4

176

Q969G2
HKEPIRLRYKLTFNQ

GGA2

576

Q9UJY4
YPTLLHQRKKQRFLS

GDPD1

26

Q8N9F7
LNKTQPHPRQKLVFY

MEIOSIN

296

C9JSJ3
QLHKLRYPPDIRATF

SBF1

1011

O95248
PRPEQHKSYKIRFNS

NOS3

601

P29474
KRHQIVNSAFPRPAY

PTPRR

76

Q15256
IQRYFRQKLTKPFLP

C2CD3

1896

Q4AC94
KIKLPRGQRFPETYH

DOCK11

981

Q5JSL3
SLRKQPYNNLKHKFP

CDK10

276

Q15131
PFVHLIRRAINKYPT

COL6A5

2486

A8TX70
KHTPYRVLRNNPKLR

GUCY2F

291

P51841
FTHLRKIRNTKYPIQ

DYNC1H1

361

Q14204
ENHKRLPYPLVQIKS

CDH15

56

P55291
PPTHKKQYQQIISRL

PPP1R13L

536

Q8WUF5
QKKLFQTLRRHPSYP

FANCD2

76

Q9BXW9
HNPLLLLTPQKVKRY

PLA2G4A

261

P47712
RPSYPLKKYSLHEQR

SPATA6L

376

Q8N4H0
RNRYPKGHSKTQPRL

PNKD

101

Q8N490
KPQKHRKSRPRSQYN

SRGAP1

486

Q7Z6B7
RLSYIHPNAFFRLPK

LRRN3

321

Q9H3W5
HRKPKQIKLPSQAYI

MAP3K21

656

Q5TCX8
IQSLLKRYQPHRVPS

NODAL

296

Q96S42
IRQFHRPPLKKYSFG

TAF1L

631

Q8IZX4
FKPDRRHPLYQKHQQ

SCRN3

341

Q0VDG4
INNHVPRKSPKYLAL

POGZ

791

Q7Z3K3
PRRNKLDHYAIIKFP

RPL23A

66

P62750
PLYYKPIQTARLHQR

STARD9

4566

Q9P2P6
RKFQKSRQPRPSSQY

ARHGAP4

486

P98171
RPKSPRKHNYRNESA

U2SURP

46

O15042
ITLHPNKRPAYQYRL

CHSY3

391

Q70JA7
PVRRHAYLQQLFSKP

CHSY3

556

Q70JA7
NPADFYHSRIPKKQR

DNTTIP2

696

Q5QJE6
RNHPDFPKRLLTAYI

UBTFL6

101

P0CB48
YQRLLEKKQPPHRQL

TRIM68

191

Q6AZZ1
RHRLQYRKKVNPDLP

ZFR2

491

Q9UPR6
RRPRPLSVYSHKLFN

SRGAP3

491

O43295
PSLIGRHFYQRKKVP

RSL1D1

166

O76021
PRITFKTKIYHPNID

UBE2L5

66

A0A1B0GUS4
YKFSPILIRHIPRQL

VPS18

596

Q9P253
KAPKSLPTHLFRQYS

TTC41P

71

Q6P2S7
PSKRHQRKVPNGYLR

ACP5

266

P13686
QLQRYLHFEKPAKPA

nan

271

Q3C1V9
RKNQTTKRFIYNIPP

ZBTB10

576

Q96DT7
LSHAKRQPRKPFIIY

SLC27A6

61

Q9Y2P4
NLKRSQSHLPYFTPK

PLEKHA1

171

Q9HB21
RNQGTPKYKPRFVHT

SULF1

526

Q8IWU6
PKYKPRFVHTRQTRS

SULF1

531

Q8IWU6
RHNHFIKTAQPYRPK

TRPM7

576

Q96QT4
QQPKKAFRYHPSLRT

ZNF439

161

Q8NDP4
SYTRRPLKQPLLYHD

MYO7A

1016

Q13402
PKQLRVRPTFSKYLA

MYOT

451

Q9UBF9