Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	minus-end-directed microtubule motor activity	DNHD1 DNAH2 DYNC1H1 DNAH14	9.37e-07	18	86	4	GO:0008569
GeneOntologyMolecularFunction	dynein light intermediate chain binding	DNHD1 DNAH2 DYNC1H1 DNAH14	6.07e-06	28	86	4	GO:0051959
GeneOntologyMolecularFunction	dynein intermediate chain binding	DNHD1 DNAH2 DYNC1H1 DNAH14	1.90e-05	37	86	4	GO:0045505
GeneOntologyMolecularFunction	RNA polymerase I core binding	RRN3 RRN3P2	1.09e-04	4	86	2	GO:0001042
GeneOntologyMolecularFunction	microtubule motor activity	DNHD1 DNAH2 DYNC1H1 DNAH14	2.37e-04	70	86	4	GO:0003777
GeneOntologyMolecularFunction	L-leucine transmembrane transporter activity	SLC7A8 SLC7A5	2.72e-04	6	86	2	GO:0015190
GeneOntologyMolecularFunction	olfactory receptor activity	OR2M4 OR5T1 OR4N5 OR10W1 OR4C45 OR5H2 OR2AE1 OR10D4P	5.39e-04	431	86	8	GO:0004984
GeneOntologyMolecularFunction	thyroid hormone transmembrane transporter activity	SLC7A8 SLC7A5	6.47e-04	9	86	2	GO:0015349
GeneOntologyMolecularFunction	RNA polymerase I general transcription initiation factor activity	RRN3 RRN3P2	6.47e-04	9	86	2	GO:0001181
GeneOntologyMolecularFunction	branched-chain amino acid transmembrane transporter activity	SLC7A8 SLC7A5	8.07e-04	10	86	2	GO:0015658
GeneOntologyMolecularFunction	RNA polymerase I core promoter sequence-specific DNA binding	RRN3 RRN3P2	9.83e-04	11	86	2	GO:0001164
GeneOntologyMolecularFunction	epoxide hydrolase activity	LTA4H ALOX15	9.83e-04	11	86	2	GO:0004301
GeneOntologyMolecularFunction	RNA polymerase I transcription regulatory region sequence-specific DNA binding	RRN3 RRN3P2	1.39e-03	13	86	2	GO:0001163
GeneOntologyMolecularFunction	histone H3K36 methyltransferase activity	SETMAR SETD5	1.39e-03	13	86	2	GO:0046975
GeneOntologyMolecularFunction	hydrolase activity, acting on ether bonds	LTA4H ALOX15	1.39e-03	13	86	2	GO:0016801
GeneOntologyMolecularFunction	ether hydrolase activity	LTA4H ALOX15	1.39e-03	13	86	2	GO:0016803
GeneOntologyMolecularFunction	zinc ion binding	UBR1 MYBBP1A SETMAR LITAF CIZ1 TRIM55 TRIM54 LTA4H ZSWIM4 NR2F1 AGTPBP1	1.51e-03	891	86	11	GO:0008270
GeneOntologyMolecularFunction	cytoskeletal motor activity	DNHD1 DNAH2 DYNC1H1 DNAH14	1.69e-03	118	86	4	GO:0003774
GeneOntologyCellularComponent	dynein complex	DNHD1 DNAH2 DYNC1H1 DNAH14	7.55e-05	54	87	4	GO:0030286
Domain	Dynein_HC_stalk	DNHD1 DNAH2 DYNC1H1 DNAH14	3.51e-07	14	83	4	IPR024743
Domain	MT	DNHD1 DNAH2 DYNC1H1 DNAH14	3.51e-07	14	83	4	PF12777
Domain	DHC_fam	DNHD1 DNAH2 DYNC1H1 DNAH14	4.77e-07	15	83	4	IPR026983
Domain	Dynein_heavy_dom	DNHD1 DNAH2 DYNC1H1 DNAH14	4.77e-07	15	83	4	IPR004273
Domain	Dynein_heavy	DNHD1 DNAH2 DYNC1H1 DNAH14	4.77e-07	15	83	4	PF03028
Domain	Dynein_heavy_chain_D4_dom	DNAH2 DYNC1H1 DNAH14	2.97e-05	14	83	3	IPR024317
Domain	Dynein_heavy_dom-2	DNHD1 DNAH2 DYNC1H1	2.97e-05	14	83	3	IPR013602
Domain	DHC_N2	DNHD1 DNAH2 DYNC1H1	2.97e-05	14	83	3	PF08393
Domain	AAA_8	DNAH2 DYNC1H1 DNAH14	2.97e-05	14	83	3	PF12780
Domain	L_AA_transporter	SLC7A8 SLC7A5	5.84e-05	3	83	2	IPR004760
Domain	Cadherin_2	PCDHA8 PCDHA5 PCDHA1 PCDHB16	2.00e-04	65	83	4	PF08266
Domain	Cadherin_N	PCDHA8 PCDHA5 PCDHA1 PCDHB16	2.00e-04	65	83	4	IPR013164
Domain	Thiol-ester_cl	CPAMD8 CD109	5.37e-04	8	83	2	PF10569
Domain	DHC_N1	DNAH2 DYNC1H1	5.37e-04	8	83	2	PF08385
Domain	MacrogloblnA2_thiol-ester-bond	CPAMD8 CD109	5.37e-04	8	83	2	IPR019565
Domain	MacrogloblnA2_CS	CPAMD8 CD109	5.37e-04	8	83	2	IPR019742
Domain	A2M_N_2	CPAMD8 CD109	5.37e-04	8	83	2	SM01359
Domain	-	CPAMD8 CD109	5.37e-04	8	83	2	2.60.40.690
Domain	Dynein_heavy_dom-1	DNAH2 DYNC1H1	5.37e-04	8	83	2	IPR013594
Domain	A2M_recep	CPAMD8 CD109	5.37e-04	8	83	2	SM01361
Domain	A2M	CPAMD8 CD109	5.37e-04	8	83	2	SM01360
Domain	Cadherin_tail	PCDHA8 PCDHA5 PCDHA1	5.90e-04	37	83	3	PF15974
Domain	Cadherin_CBD	PCDHA8 PCDHA5 PCDHA1	5.90e-04	37	83	3	IPR031904
Domain	A2M_N	CPAMD8 CD109	8.58e-04	10	83	2	PF01835
Domain	A2M_N	CPAMD8 CD109	8.58e-04	10	83	2	IPR002890
Domain	A-macroglobulin_rcpt-bd	CPAMD8 CD109	8.58e-04	10	83	2	IPR009048
Domain	ALPHA_2_MACROGLOBULIN	CPAMD8 CD109	8.58e-04	10	83	2	PS00477
Domain	A2M	CPAMD8 CD109	8.58e-04	10	83	2	PF00207
Domain	A2M_N_2	CPAMD8 CD109	8.58e-04	10	83	2	IPR011625
Domain	A2M_comp	CPAMD8 CD109	8.58e-04	10	83	2	IPR011626
Domain	A2M_N_2	CPAMD8 CD109	8.58e-04	10	83	2	PF07703
Domain	A2M_recep	CPAMD8 CD109	8.58e-04	10	83	2	PF07677
Domain	A2M_comp	CPAMD8 CD109	8.58e-04	10	83	2	PF07678
Domain	Macroglobln_a2	CPAMD8 CD109	8.58e-04	10	83	2	IPR001599
Domain	COS_domain	TRIM55 TRIM54	1.25e-03	12	83	2	IPR017903
Domain	COS	TRIM55 TRIM54	1.25e-03	12	83	2	PS51262
Domain	-	CPAMD8 CD109	1.25e-03	12	83	2	1.50.10.20
Domain	Cadherin_CS	PCDHA8 PCDHA5 PCDHA1 PCDHB16	1.42e-03	109	83	4	IPR020894
Domain	AA_permease_2	SLC7A8 SLC7A5	1.47e-03	13	83	2	PF13520
Domain	AA/rel_permease1	SLC7A8 SLC7A5	1.47e-03	13	83	2	IPR002293
Domain	CADHERIN_1	PCDHA8 PCDHA5 PCDHA1 PCDHB16	1.62e-03	113	83	4	PS00232
Domain	Cadherin	PCDHA8 PCDHA5 PCDHA1 PCDHB16	1.62e-03	113	83	4	PF00028
Domain	CADHERIN_2	PCDHA8 PCDHA5 PCDHA1 PCDHB16	1.67e-03	114	83	4	PS50268
Domain	-	PCDHA8 PCDHA5 PCDHA1 PCDHB16	1.67e-03	114	83	4	2.60.40.60
Domain	ATPase_dyneun-rel_AAA	DNAH2 DYNC1H1	1.72e-03	14	83	2	IPR011704
Domain	AAA_5	DNAH2 DYNC1H1	1.72e-03	14	83	2	PF07728
Domain	CA	PCDHA8 PCDHA5 PCDHA1 PCDHB16	1.72e-03	115	83	4	SM00112
Domain	Cadherin-like	PCDHA8 PCDHA5 PCDHA1 PCDHB16	1.78e-03	116	83	4	IPR015919
Domain	Cadherin	PCDHA8 PCDHA5 PCDHA1 PCDHB16	1.89e-03	118	83	4	IPR002126
Domain	Terpenoid_cyclase/PrenylTrfase	CPAMD8 CD109	2.85e-03	18	83	2	IPR008930
Domain	ARM-type_fold	MYBBP1A LTA4H MMS19 NUP188 LYST AGTPBP1	4.00e-03	339	83	6	IPR016024
Domain	AA-permease/SLC12A_dom	SLC7A8 SLC7A5	4.25e-03	22	83	2	IPR004841
Domain	AA_permease	SLC7A8 SLC7A5	4.25e-03	22	83	2	PF00324
Pubmed	E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.	ANK1 FAM120C DROSHA ARID5B DNAH2 PCDHA5 LTA4H NUP188 BIRC6 DYNC1H1 DNAH14	2.58e-06	736	88	11	29676528
Pubmed	Non-motor symptoms associated with progressive loss of dopaminergic neurons in a mouse model of Parkinson's disease.	RRN3 RRN3P2	6.33e-06	2	88	2	38745938
Pubmed	Rrn3 phosphorylation is a regulatory checkpoint for ribosome biogenesis.	RRN3 RRN3P2	6.33e-06	2	88	2	12015311
Pubmed	DNA binding by the ribosomal DNA transcription factor rrn3 is essential for ribosomal DNA transcription.	RRN3 RRN3P2	6.33e-06	2	88	2	23393135
Pubmed	Function of the growth-regulated transcription initiation factor TIF-IA in initiation complex formation at the murine ribosomal gene promoter.	RRN3 RRN3P2	6.33e-06	2	88	2	8413268
Pubmed	Establishment and characterization of mammalian cell lines stably expressing human L-type amino acid transporters.	SLC7A8 SLC7A5	6.33e-06	2	88	2	19075510
Pubmed	Overexpression of L-Type Amino Acid Transporter 1 (LAT1) and 2 (LAT2): Novel Markers of Neuroendocrine Tumors.	SLC7A8 SLC7A5	6.33e-06	2	88	2	27224648
Pubmed	Transport of a neurotoxicant by molecular mimicry: the methylmercury-L-cysteine complex is a substrate for human L-type large neutral amino acid transporter (LAT) 1 and LAT2.	SLC7A8 SLC7A5	6.33e-06	2	88	2	12117417
Pubmed	Quantitative and electron microscopic studies of sensory ganglion cells of the Sprawling mouse.	GPI DYNC1H1	6.33e-06	2	88	2	894335
Pubmed	Expression and functional characterisation of System L amino acid transporters in the human term placenta.	SLC7A8 SLC7A5	6.33e-06	2	88	2	26050671
Pubmed	Stimulation of noradrenergic transmission by reboxetine is beneficial for a mouse model of progressive parkinsonism.	RRN3 RRN3P2	6.33e-06	2	88	2	30918302
Pubmed	Impaired rRNA synthesis triggers homeostatic responses in hippocampal neurons.	RRN3 RRN3P2	6.33e-06	2	88	2	24273493
Pubmed	Muscle RING-finger 2 and 3 maintain striated-muscle structure and function.	TRIM55 TRIM54	6.33e-06	2	88	2	27493870
Pubmed	A neuroprotective phase precedes striatal degeneration upon nucleolar stress.	RRN3 RRN3P2	6.33e-06	2	88	2	23764776
Pubmed	Heat shock represses rRNA synthesis by inactivation of TIF-IA and lncRNA-dependent changes in nucleosome positioning.	RRN3 RRN3P2	6.33e-06	2	88	2	27257073
Pubmed	ERK-dependent phosphorylation of the transcription initiation factor TIF-IA is required for RNA polymerase I transcription and cell growth.	RRN3 RRN3P2	6.33e-06	2	88	2	12620228
Pubmed	Activation of system L heterodimeric amino acid exchangers by intracellular substrates.	SLC7A8 SLC7A5	6.33e-06	2	88	2	11847106
Pubmed	Integration of the Deacetylase SIRT1 in the Response to Nucleolar Stress: Metabolic Implications for Neurodegenerative Diseases.	RRN3 RRN3P2	6.33e-06	2	88	2	31110473
Pubmed	Monoallelic yet combinatorial expression of variable exons of the protocadherin-alpha gene cluster in single neurons.	PCDHA8 PCDHA5 PCDHA1	6.97e-06	15	88	3	15640798
Pubmed	Alpha protocadherins and Pyk2 kinase regulate cortical neuron migration and cytoskeletal dynamics via Rac1 GTPase and WAVE complex in mice.	PCDHA8 PCDHA5 PCDHA1	1.04e-05	17	88	3	29911975
Pubmed	Genomic organization of the family of CNR cadherin genes in mice and humans.	PCDHA8 PCDHA5 PCDHA1	1.24e-05	18	88	3	10662547
Pubmed	CNR/Pcdhalpha family in subplate neurons, and developing cortical connectivity.	PCDHA8 PCDHA5 PCDHA1	1.24e-05	18	88	3	15570159
Pubmed	Clustered gamma-protocadherins regulate cortical interneuron programmed cell death.	PCDHA8 PCDHA5 PCDHA1 PCDHB16	1.36e-05	57	88	4	32633719
Pubmed	CTCF Governs the Identity and Migration of MGE-Derived Cortical Interneurons.	PCDHA8 PCDHA5 PCDHA1 PCDHB16	1.46e-05	58	88	4	30377227
Pubmed	Identification of stereoselective transporters for S-nitroso-L-cysteine: role of LAT1 and LAT2 in biological activity of S-nitrosothiols.	SLC7A8 SLC7A5	1.90e-05	3	88	2	15769744
Pubmed	Small molecule inhibitors provide insights into the relevance of LAT1 and LAT2 in materno-foetal amino acid transport.	SLC7A8 SLC7A5	1.90e-05	3	88	2	33001560
Pubmed	Nucleolar stress controls mutant Huntington toxicity and monitors Huntington's disease progression.	RRN3 RRN3P2	1.90e-05	3	88	2	34880223
Pubmed	Abnormalities in the genes that encode Large Amino Acid Transporters increase the risk of Autism Spectrum Disorder.	SLC7A8 SLC7A5	1.90e-05	3	88	2	31701662
Pubmed	TAF12 recruits Gadd45a and the nucleotide excision repair complex to the promoter of rRNA genes leading to active DNA demethylation.	RRN3 RRN3P2	1.90e-05	3	88	2	19217408
Pubmed	Genetic polymorphisms in the amino acid transporters LAT1 and LAT2 in relation to the pharmacokinetics and side effects of melphalan.	SLC7A8 SLC7A5	1.90e-05	3	88	2	17558306
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	DACT1 SETD5 ADGRB2 NADK SLC7A5 NUP188 MLXIP FHIP1B BIRC6 LYST MED13 DYNC1H1	2.22e-05	1105	88	12	35748872
Pubmed	Comparative DNA sequence analysis of mouse and human protocadherin gene clusters.	PCDHA8 PCDHA5 PCDHA1 PCDHB16	2.75e-05	68	88	4	11230163
Pubmed	Developmental epigenetic modification regulates stochastic expression of clustered protocadherin genes, generating single neuron diversity.	PCDHA8 PCDHA5 PCDHA1	3.05e-05	24	88	3	24698270
Pubmed	A striking organization of a large family of human neural cadherin-like cell adhesion genes.	PCDHA8 PCDHA5 PCDHA1 PCDHB16	3.45e-05	72	88	4	10380929
Pubmed	Association of 4F2hc with light chains LAT1, LAT2 or y+LAT2 requires different domains.	SLC7A8 SLC7A5	3.79e-05	4	88	2	11311135
Pubmed	Identification of muscle specific ring finger proteins as potential regulators of the titin kinase domain.	TRIM55 TRIM54	3.79e-05	4	88	2	11243782
Pubmed	The Heavy Chain 4F2hc Modulates the Substrate Affinity and Specificity of the Light Chains LAT1 and LAT2.	SLC7A8 SLC7A5	3.79e-05	4	88	2	33066406
Pubmed	Akt activation enhances ribosomal RNA synthesis through casein kinase II and TIF-IA.	RRN3 RRN3P2	3.79e-05	4	88	2	24297901
Pubmed	LAT2, a new basolateral 4F2hc/CD98-associated amino acid transporter of kidney and intestine.	SLC7A8 SLC7A5	3.79e-05	4	88	2	10574970
Pubmed	Genetic mutations linked to Parkinson's disease differentially control nucleolar activity in pre-symptomatic mouse models.	RRN3 RRN3P2	3.79e-05	4	88	2	28360124
Pubmed	Cadherin superfamily genes: functions, genomic organization, and neurologic diversity.	PCDHA8 PCDHA5 PCDHA1 PCDHB16	3.85e-05	74	88	4	10817752
Pubmed	A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.	DACT1 DROSHA TRIM55 TRIM54 BIRC6 NDUFS1 MED13 AGTPBP1	3.89e-05	497	88	8	23414517
Pubmed	Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members.	PCDHA8 PCDHA5 PCDHA1 PCDHB16	4.50e-05	77	88	4	10835267
Pubmed	Interaction with protocadherin-gamma regulates the cell surface expression of protocadherin-alpha.	PCDHA8 PCDHA5 PCDHA1	4.90e-05	28	88	3	15347688
Pubmed	Large exons encoding multiple ectodomains are a characteristic feature of protocadherin genes.	PCDHA8 PCDHA5 PCDHA1 PCDHB16	5.23e-05	80	88	4	10716726
Pubmed	Identification of LAT4, a novel amino acid transporter with system L activity.	SLC7A8 SLC7A5	6.30e-05	5	88	2	15659399
Pubmed	Phosphorylation by casein kinase 2 facilitates rRNA gene transcription by promoting dissociation of TIF-IA from elongating RNA polymerase I.	RRN3 RRN3P2	6.30e-05	5	88	2	18559419
Pubmed	Activation of an endogenous suicide response after perturbation of rRNA synthesis leads to neurodegeneration in mice.	RRN3 RRN3P2	6.30e-05	5	88	2	19036968
Pubmed	Mesenchymal dysplasia: a recessive mutation on chromosome 13 of the mouse.	LYST AGTPBP1	6.30e-05	5	88	2	8830098
Pubmed	The nucleolus as a stress sensor: JNK2 inactivates the transcription factor TIF-IA and down-regulates rRNA synthesis.	RRN3 RRN3P2	6.30e-05	5	88	2	15805466
Pubmed	Nucleolar disruption in dopaminergic neurons leads to oxidative damage and parkinsonism through repression of mammalian target of rapamycin signaling.	RRN3 RRN3P2	6.30e-05	5	88	2	21228155
Pubmed	Y+ and y+ L arginine transporters in neuronal cells expressing tyrosine hydroxylase.	SLC7A8 SLC7A5	6.30e-05	5	88	2	16085056
Pubmed	Transcription factors expressed in olfactory bulb local progenitor cells revealed by genome-wide transcriptome profiling.	MYBBP1A ATF7IP ARID5B NR2F1	8.65e-05	91	88	4	21194568
Pubmed	The monocarboxylate transporter 8 and L-type amino acid transporters 1 and 2 are expressed in mouse skeletons and in osteoblastic MC3T3-E1 cells.	SLC7A8 SLC7A5	9.43e-05	6	88	2	19133747
Pubmed	Mice deficient in MCT8 reveal a mechanism regulating thyroid hormone secretion.	SLC7A8 SLC7A5	9.43e-05	6	88	2	20679730
Pubmed	Amino acid availability acts as a metabolic rheostat to determine the magnitude of ILC2 responses.	SLC7A8 SLC7A5	9.43e-05	6	88	2	36571761
Pubmed	Lack of effect of common single nucleotide polymorphisms in leukotriene pathway genes on platelet reactivity in patients with diabetes.	LTA4H ALOX15	9.43e-05	6	88	2	23828562
Pubmed	E3-ligase knock down revealed differential titin degradation by autopagy and the ubiquitin proteasome system.	TRIM55 TRIM54	9.43e-05	6	88	2	34702928
Pubmed	Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism.	GPI TGIF2 CFAP92 TRMT2A ANAPC1 ARID5B NUP188 CYB5R4 BIRC6 ALG6 NDUFS1 MED13	1.28e-04	1327	88	12	32694731
Pubmed	Transport of Iodothyronines by Human L-Type Amino Acid Transporters.	SLC7A8 SLC7A5	1.32e-04	7	88	2	26305885
Pubmed	A unique enhancer boundary complex on the mouse ribosomal RNA genes persists after loss of Rrn3 or UBF and the inactivation of RNA polymerase I transcription.	RRN3 RRN3P2	1.32e-04	7	88	2	28715449
Pubmed	Muscle-specific RING finger-1 interacts with titin to regulate sarcomeric M-line and thick filament structure and may have nuclear functions via its interaction with glucocorticoid modulatory element binding protein-1.	TRIM55 TRIM54	1.32e-04	7	88	2	11927605
Pubmed	Nuclear actin and myosin I are required for RNA polymerase I transcription.	RRN3 RRN3P2	1.32e-04	7	88	2	15558034
Pubmed	SUMO targets the APC/C to regulate transition from metaphase to anaphase.	ANAPC1 RACGAP1 LYST	1.56e-04	41	88	3	29549242
Pubmed	Genetic variation in the leukotriene pathway and carotid intima-media thickness: a 2-stage replication study.	LTA4H ALOX15	1.75e-04	8	88	2	19131661
Pubmed	Metabolic activation-related CD147-CD98 complex.	SLC7A8 SLC7A5	2.25e-04	9	88	2	15901826
Pubmed	The expression of thyroid hormone transporters in the human fetal cerebral cortex during early development and in N-Tera-2 neurodifferentiation.	SLC7A8 SLC7A5	2.25e-04	9	88	2	21486766
Pubmed	Developmental and cell type-specific expression of thyroid hormone transporters in the mouse brain and in primary brain cells.	SLC7A8 SLC7A5	2.25e-04	9	88	2	21264952
Pubmed	Developmental regulation of MURF ubiquitin ligases and autophagy proteins nbr1, p62/SQSTM1 and LC3 during cardiac myofibril assembly and turnover.	TRIM55 TRIM54	2.25e-04	9	88	2	21185285
Pubmed	Different evolutionary processes shaped the mouse and human olfactory receptor gene families.	OR5T1 OR4N5 OR10W1 OR4C45 OR5H2 OR10D4P	2.31e-04	340	88	6	11875048
Pubmed	The olfactory receptor gene superfamily of the mouse.	OR5T1 OR4N5 OR10W1 OR4C45 OR5H2 OR10D4P	2.31e-04	340	88	6	11802173
Pubmed	Multiple mouse chromosomal loci for dynein-based motility.	DNAH2 DYNC1H1 DNAH14	2.34e-04	47	88	3	8812413
Pubmed	A unified nomenclature for vertebrate olfactory receptors.	OR5T1 OR4N5 OR10W1 OR4C45 OR5H2 OR10D4P	2.42e-04	343	88	6	32295537
Pubmed	Odorant receptor expressed sequence tags demonstrate olfactory expression of over 400 genes, extensive alternate splicing and unequal expression levels.	OR5T1 OR4N5 OR10W1 OR4C45 OR5H2 OR10D4P	2.54e-04	346	88	6	14611657
Pubmed	Suppression of mitochondrial respiration through recruitment of p160 myb binding protein to PGC-1alpha: modulation by p38 MAPK.	MYBBP1A ANAPC1	2.81e-04	10	88	2	14744933
Pubmed	Dynein and kinesin regulate stress-granule and P-body dynamics.	DNAH2 DYNC1H1	2.81e-04	10	88	2	19825938
Pubmed	Diversity revealed by a novel family of cadherins expressed in neurons at a synaptic complex.	PCDHA8 PCDHA5	3.43e-04	11	88	2	9655502
Pubmed	Proteins of the CNR family are multiple receptors for Reelin.	PCDHA8 PCDHA5	4.11e-04	12	88	2	10612399
Pubmed	Genetic inactivation of the transcription factor TIF-IA leads to nucleolar disruption, cell cycle arrest, and p53-mediated apoptosis.	RRN3 RRN3P2	4.11e-04	12	88	2	15989966
Pubmed	Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains.	GPI MYBBP1A SETD5 ANAPC1 DHX40 INTS3 DYNC1H1	4.16e-04	533	88	7	30554943
Pubmed	Epigenetic functions of smchd1 repress gene clusters on the inactive X chromosome and on autosomes.	PCDHA8 PCDHA1 PCDHB16	4.59e-04	59	88	3	23754746
Pubmed	Anticancer sulfonamides target splicing by inducing RBM39 degradation via recruitment to DCAF15.	GPI MYBBP1A FAM120C DROSHA DHX40 LTA4H MMS19 DYNC1H1	4.60e-04	714	88	8	28302793
Pubmed	Chromosome 13q12 encoded Rho GTPase activating protein suppresses growth of breast carcinoma cells, and yeast two-hybrid screen shows its interaction with several proteins.	STARD13 ADGRB2	4.85e-04	13	88	2	14697242
Pubmed	An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.	ANAPC1 RACGAP1 TMEM192 SLC7A5 BIRC6 NDUFS1 STAT2 AGTPBP1	5.47e-04	733	88	8	34672954
Pubmed	Genome-wide CRISPR-cas9 knockout screening identifies GRB7 as a driver for MEK inhibitor resistance in KRAS mutant colon cancer.	MYBBP1A RACGAP1 MMS19	5.57e-04	63	88	3	34718347
Pubmed	A multi-factor trafficking site on the spliceosome remodeling enzyme BRR2 recruits C9ORF78 to regulate alternative splicing.	TRMT2A ANAPC1 RACGAP1 MMS19 NDUFS1 DYNC1H1 SNTB2	5.57e-04	560	88	7	35241646
Pubmed	A set of proteins interacting with transcription factor Sp1 identified in a two-hybrid screening.	DROSHA ATF7IP	5.65e-04	14	88	2	10976766
Pubmed	Identification of dynein heavy chain genes expressed in human and mouse testis: chromosomal localization of an axonemal dynein gene.	DNAH2 DYNC1H1	5.65e-04	14	88	2	9373155
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	SETD5 MLXIP FHIP1B DYNC1H1 PCDHB16 AGTPBP1	5.98e-04	407	88	6	12693553
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	STARD13 GPI UBR1 MYBBP1A DHX40 RACGAP1 PTPN23 MMS19 BIRC6 NDUFS1 DYNC1H1	6.11e-04	1353	88	11	29467282
Pubmed	HAPSTR1 localizes HUWE1 to the nucleus to limit stress signaling pathways.	MYBBP1A ANAPC1 MRPL43 NUP188 BIRC6 NDUFS1 DYNC1H1	6.25e-04	571	88	7	37167062
Pubmed	Placental and fetal characteristics of the Ohia mouse line recapitulate outcomes in human hypoplastic left heart syndrome.	SLC7A8 SLC7A5	7.42e-04	16	88	2	34890862
Pubmed	Neuronal 3',3,5-triiodothyronine (T3) uptake and behavioral phenotype of mice deficient in Mct8, the neuronal T3 transporter mutated in Allan-Herndon-Dudley syndrome.	SLC7A8 SLC7A5	8.40e-04	17	88	2	19641107
Pubmed	The DNA sequence and comparative analysis of human chromosome 5.	PCDHA8 PCDHA5 PCDHA1	9.27e-04	75	88	3	15372022
Pubmed	Changes in thyroid status during perinatal development of MCT8-deficient male mice.	SLC7A8 SLC7A5	9.43e-04	18	88	2	23696569
Pubmed	The targeted inactivation of TRβ gene in thyroid follicular cells suggests a new mechanism of regulation of thyroid hormone production.	SLC7A8 SLC7A5	1.17e-03	20	88	2	24265449
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	MYBBP1A ANAPC1 LTA4H NUP188 BIRC6 NDUFS1 DYNC1H1	1.36e-03	653	88	7	22586326
Pubmed	SARS-CoV-2 Nsp6 damages Drosophila heart and mouse cardiomyocytes through MGA/MAX complex-mediated increased glycolysis.	MYBBP1A EIF2B2 SLC7A5 MMS19 NUP188 BIRC6 NDUFS1	1.41e-03	657	88	7	36180527
Pubmed	Murine embryonic stem cell-derived pyramidal neurons integrate into the cerebral cortex and appropriately project axons to subcortical targets.	FEZF1 NR2F1	1.55e-03	23	88	2	20089898
Pubmed	A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene.	TGIF2 ANAPC1 SHOC1 NADK FHIP1B	1.56e-03	331	88	5	19490893
Cytoband	5q31	PCDHA8 PCDHA5 PCDHA1 PCDHB16	7.41e-05	115	88	4	5q31
GeneFamily	Clustered protocadherins	PCDHA8 PCDHA5 PCDHA1 PCDHB16	6.40e-05	64	61	4	20
GeneFamily	C3 and PZP like, alpha-2-macroglobulin domain containing	CPAMD8 CD109	3.97e-04	9	61	2	1234
GeneFamily	Dyneins, axonemal	DNAH2 DNAH14	1.47e-03	17	61	2	536
Disease	1,5 anhydroglucitol measurement	PCDHA8 PCDHA5 PCDHA1	7.71e-05	29	84	3	EFO_0008009
Disease	post-traumatic stress disorder symptom measurement	PCDHA8 PCDHA5 PCDHA1 ADCY5	9.03e-05	82	84	4	EFO_0008535
Disease	Parkinson's disease (implicated_via_orthology)	GPI RRN3 RRN3P2 ADCY5	1.07e-03	157	84	4	DOID:14330 (implicated_via_orthology)
Disease	spermatogenic failure (is_implicated_in)	SHOC1 CFAP61	1.95e-03	23	84	2	DOID:0111910 (is_implicated_in)
Disease	visceral adipose tissue measurement, body mass index	PCDHA8 PCDHA5 PCDHA1	1.99e-03	87	84	3	EFO_0004340, EFO_0004765

Protein segments in the cluster

Peptide	Gene	Start	Entry
PLPDQLMCVISASVH	BEST4	101	Q8NFU0
HRMTPACPLLLSVIL	ADGRB2	11	O60241
PCTPLNTLFMHLFVA	CFAP61	96	Q8NHU2
LLMPSPSHLHCVAAI	BIRC6	3486	Q9NR09
TISNVLFFILPPICM	ACER2	36	Q5QJU3
ILPRHIQLIMSFCST	ALG6	291	Q9Y672
DTQHILCHLNITMPP	ANK1	1351	P16157
QLAVMPLLAGTHCLP	CFAP92	381	Q9ULG3
VMHLPLPTKLTPNTC	DNHD1	4726	Q96M86
LVCLVMLAFHAARPP	ADCY5	251	O95622
TLPKILSHIAPAFCM	AGTPBP1	1056	Q9UPW5
QCSMPLHVAPLLAAA	NR2F1	266	P10589
PHPAITATLLDFMCR	INTS3	426	Q68E01
HIPPQLMEKCAALSV	PTPN23	416	Q9H3S7
MIHVKRCTPIPALLF	SLC7A8	356	Q9UHI5
VQHPITFLDRPIQMC	LITAF	81	Q99732
MENPCLTFVTPTLLA	LTA4H	271	P09960
FSMLHPLDEITPLVC	ANAPC1	211	Q9H1A4
LVPCNHVMLSQKPAV	FHIP1B	426	Q8N612
AICHPLQYPLLMTLT	OR10W1	116	Q8NGF6
CVHAMILTPLTFQLP	OR10D4P	151	Q8NGN7
TCSLMPHVPFKLVST	PCDHA8	386	Q9Y5H6
EMPACILTLPAVQHI	KLHL33	506	A6NCF5
QCMHALTRLPTPVLL	MMS19	976	Q96T76
PAIMITPICPHSLSF	NADK	341	O95544
FLLMSPRLEVPCSHA	LGALS12	201	Q96DT0
ICHPLQYTILMNPKL	OR2M4	126	Q96R27
PNVIDHFMCDLVPLL	OR4C45	166	A6NMZ5
VTVFCTLFTPMLNPL	OR4C45	266	A6NMZ5
VSLFHTVIFPLMNPV	OR4N5	271	Q8IXE1
IIPLFMISCTDPSIN	OR5H2	186	Q8NGV7
LTPVPSLVFTCVMTL	SLC7A5	371	Q01650
IVVATMRCLPSIHPI	ALOX15	371	P16050
MIPCDFLIPVQTQHP	GPI	401	P06744
CSLMPHVPFKLVSTF	PCDHA5	386	Q9Y5H7
PMFLSLFSRHPVLCQ	MYBBP1A	996	Q9BQG0
ILLICIDPQLHTPMY	OR2AE1	46	Q8NHA4
TCSLMPHVPFKLVST	PCDHA1	386	Q9Y5I3
PCILHFQVLMENPLE	PCDHB16	101	Q9NRJ7
HCSLPILRPMVLSTL	MLXIP	871	Q9HAP2
IRHVFCNMPPLLAIS	OR5T1	186	Q8NG75
MLPHCPLQSLSGSLV	GSAP	381	A4D1B5
MQGPPLLTAAHLLCV	CD109	1	Q6YHK3
SPLHAVAVQSPMFLL	DACT1	271	Q9NYF0
PLQLCEPLHSILLTM	FRMPD2	126	Q68DX3
CVTSLHLAVTPSMVP	CPAMD8	541	Q8IZJ3
PANVPTHLLLMCCVL	FAM120C	756	Q9NX05
AVQMLVSVSHFLPLP	CARD19	166	Q96LW7
QCQMLPYHATLTPLL	CORIN	146	Q9Y5Q5
PPFLVLTVMNAVCIL	DNAH14	2371	Q0VDD8
TISCINAMLTQIPPL	ECM2	326	O94769
ALPLPMACTLTQFVS	ATF7IP	1221	Q6VMQ6
PLSHMLPCISLESLV	LYST	936	Q99698
SLPIHPMITNVAKQC	DYNC1H1	206	Q14204
HSTPLIVCAPMFKLS	EIF2B2	261	P49770
MVEFPLPPHLTCAVI	DHX40	486	Q8IX18
LVCLMPTIHFRPAES	DNAH2	4356	Q9P225
PCLSMIASHFVPPRV	RRN3	146	Q9NYV6
CHPIPAPLAQKMLTF	AK9	1326	Q5TCS8
MLSAVSCLPIVPALT	MRPL43	196	Q8N983
MFAHAPLTNIPLCKV	DROSHA	606	Q9NRR4
TPMNLAVCLAPSLFH	STARD13	806	Q9Y3M8
VDLFPQTPHCEMLIL	TRMT2A	571	Q8IZ69
LLHRAFVVETQPCMP	STAT2	311	P52630
VMEFLLANHPLDCPI	NDUFS1	116	P28331
HLNSSIPCMIPFVPV	FEZF1	66	A0PJY2
LNMLPGLIHSPLICT	SETD5	736	Q9C0A6
FLNHSCEPNLLMIPV	SETMAR	221	Q53H47
ELEMPLTPLFLTCQH	SHOC1	261	Q5VXU9
PQALHRVALSMALPC	SLC35E2A	246	P0CK97
LLRCFLEMVQTLPPH	MED13	1666	Q9UHV7
VTHDTRLFCLMLPPS	CYB5R4	286	Q7L1T6
RLFCLMLPPSTHLQV	CYB5R4	291	Q7L1T6
SQTSPMIPSIVVHCV	RACGAP1	356	Q9H0H5
TFVLIPPHSKLMTCF	REELD1	96	A0A1B0GV85
PTNVLSLSVCSMPLH	TGIF2	121	Q9GZN2
VLSPLMQPLAFHSLV	ARID5B	1111	Q14865
HMSQACLLSLLPVPR	CIZ1	626	Q9ULV3
SNLCMPDLPHLLAFL	RINL	111	Q6ZS11
EMFSKPVVILPCQHN	TRIM54	31	Q9BYV2
LLLILCMQHSFPEPG	TMEM192	151	Q8IY95
EMFTKPVVILPCQHN	TRIM55	31	Q9BYV6
HSIMALALPCKLTIP	TNS4	541	Q8IZW8
LCIEPMPHSAIAKNL	UBR1	776	Q8IWV7
VCGMFPHLLSPLLQL	NUP188	436	Q5SRE5
PCLSMIASHFVPPRV	RRN3P2	146	A6NIE6
LTISDTPFIHMLCPH	TLR6	336	Q9Y2C9
FHLCISMVPPNLLKI	TTC39C	226	Q8N584
TMDLHSCPKPIVFVL	SNTB2	511	Q13425
VPLIIRSIHCAPMLS	ZSWIM4	866	Q9H7M6