Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionGTPase activator activity

TBC1D3E TBC1D3 TBC1D3H TBC1D3L TBC1D3D FLCN TBC1D3I TBC1D3G TBC1D3C TBC1D3B TBC1D26 TBC1D3K TBC1D3F

1.31e-132795013GO:0005096
GeneOntologyMolecularFunctionGTPase regulator activity

TBC1D3E TBC1D3 TBC1D3H TBC1D3L TBC1D3D OBSCN FLCN TBC1D3I TBC1D3G TBC1D3C TBC1D3B TBC1D26 TBC1D3K TBC1D3F

1.57e-115075014GO:0030695
GeneOntologyMolecularFunctionnucleoside-triphosphatase regulator activity

TBC1D3E TBC1D3 TBC1D3H TBC1D3L TBC1D3D OBSCN FLCN TBC1D3I TBC1D3G TBC1D3C TBC1D3B TBC1D26 TBC1D3K TBC1D3F

1.57e-115075014GO:0060589
GeneOntologyMolecularFunctionenzyme activator activity

TBC1D3E TBC1D3 TBC1D3H TBC1D3L TBC1D3D FLCN TBC1D3I TBC1D3G TBC1D3C TBC1D3B TBC1D26 TBC1D3K TBC1D3F

5.35e-096565013GO:0008047
GeneOntologyMolecularFunctionenzyme regulator activity

TBC1D3E TBC1D3 TBC1D3H TBC1D3L TBC1D3D OBSCN FLCN TBC1D3I TBC1D3G TBC1D3C TBC1D3B TBC1D26 TBC1D3K TBC1D3F

6.44e-0614185014GO:0030234
GeneOntologyMolecularFunctionmolecular function activator activity

TBC1D3E TBC1D3 TBC1D3H TBC1D3L TBC1D3D FLCN TBC1D3I TBC1D3G TBC1D3C TBC1D3B TBC1D26 TBC1D3K TBC1D3F

7.38e-0612335013GO:0140677
GeneOntologyMolecularFunctionglycerol kinase activity

GK GK2

1.84e-053502GO:0004370
GeneOntologyBiologicalProcessactivation of GTPase activity

TBC1D3E TBC1D3 TBC1D3H TBC1D3L TBC1D3D TBC1D3I TBC1D3G TBC1D3C TBC1D3B TBC1D26 TBC1D3K TBC1D3F

1.51e-171094812GO:0090630
GeneOntologyBiologicalProcesspositive regulation of GTPase activity

TBC1D3E TBC1D3 TBC1D3H TBC1D3L TBC1D3D TBC1D3I TBC1D3G TBC1D3C TBC1D3B TBC1D26 TBC1D3K TBC1D3F

2.74e-132444812GO:0043547
GeneOntologyBiologicalProcessregulation of GTPase activity

TBC1D3E TBC1D3 TBC1D3H TBC1D3L TBC1D3D TBC1D3I TBC1D3G TBC1D3C TBC1D3B TBC1D26 TBC1D3K TBC1D3F

1.14e-113354812GO:0043087
GeneOntologyBiologicalProcesspositive regulation of hydrolase activity

TBC1D3E TBC1D3 TBC1D3H TBC1D3L TBC1D3D TBC1D3I TBC1D3G TBC1D3C TBC1D3B TBC1D26 TBC1D3K TBC1D3F

1.11e-094994812GO:0051345
GeneOntologyBiologicalProcessregulation of hydrolase activity

TBC1D3E TBC1D3 TBC1D3H TBC1D3L TBC1D3D TBC1D3I TBC1D3G TBC1D3C TBC1D3B TBC1D26 TBC1D3K TBC1D3F

5.55e-078784812GO:0051336
GeneOntologyBiologicalProcessglycerol-3-phosphate metabolic process

GK GK2 GPAM

1.40e-0610483GO:0006072
GeneOntologyBiologicalProcessalditol phosphate metabolic process

GK GK2 GPAM

2.56e-0612483GO:0052646
GeneOntologyBiologicalProcesspositive regulation of catalytic activity

TBC1D3E TBC1D3 TBC1D3H TBC1D3L TBC1D3D TBC1D3I TBC1D3G TBC1D3C TBC1D3B TBC1D26 TBC1D3K TBC1D3F

2.90e-0610284812GO:0043085
GeneOntologyBiologicalProcessglycerol-3-phosphate biosynthetic process

GK GK2

1.59e-053482GO:0046167
GeneOntologyBiologicalProcesspositive regulation of molecular function

TBC1D3E TBC1D3 TBC1D3H TBC1D3L TBC1D3D TBC1D3I TBC1D3G TBC1D3C TBC1D3B TBC1D26 TBC1D3K TBC1D3F

7.89e-0514304812GO:0044093
GeneOntologyBiologicalProcessglycerol catabolic process

GK GK2

7.91e-056482GO:0019563
GeneOntologyBiologicalProcessalditol catabolic process

GK GK2

1.11e-047482GO:0019405
GeneOntologyBiologicalProcesstriglyceride metabolic process

GK GK2 LPL GPAM

2.16e-04127484GO:0006641
GeneOntologyBiologicalProcesstriglyceride biosynthetic process

GK LPL GPAM

2.41e-0452483GO:0019432
GeneOntologyBiologicalProcesspolyol catabolic process

GK GK2

3.45e-0412482GO:0046174
GeneOntologyBiologicalProcessglycerolipid biosynthetic process

GK LPL GPAM PI4KAP2 PLD1

3.87e-04268485GO:0045017
GeneOntologyBiologicalProcessneutral lipid biosynthetic process

GK LPL GPAM

4.26e-0463483GO:0046460
GeneOntologyBiologicalProcessacylglycerol biosynthetic process

GK LPL GPAM

4.26e-0463483GO:0046463
GeneOntologyBiologicalProcessglycerolipid metabolic process

GK GK2 LPL GPAM PI4KAP2 PLD1

4.58e-04429486GO:0046486
GeneOntologyBiologicalProcessacylglycerol metabolic process

GK GK2 LPL GPAM

4.73e-04156484GO:0006639
GeneOntologyBiologicalProcessneutral lipid metabolic process

GK GK2 LPL GPAM

4.96e-04158484GO:0006638
GeneOntologyCellularComponentdynactin complex

ACTR1B ACTR1A

1.37e-048472GO:0005869
MousePhenooligozoospermia

FSIP2 UBR2 GK GK2 FSIP1 ASPM JMJD1C

6.17e-06384277MP:0002687
MousePhenodecreased male germ cell number

FSIP2 UBR2 DDIAS GK GK2 FSIP1 ASPM JMJD1C

1.89e-05640278MP:0004901
MousePhenodecreased germ cell number

FSIP2 UBR2 DDIAS GK GK2 FSIP1 ASPM JMJD1C

3.15e-05687278MP:0002209
MousePhenodecreased sperm mitochondrial sheath size

GK GK2

5.36e-056272MP:0014464
MousePhenoabnormal sperm mitochondrial sheath size

GK GK2

5.36e-056272MP:0014462
MousePhenoabnormal sperm number

FSIP2 UBR2 GK GK2 FSIP1 ASPM JMJD1C

1.39e-04624277MP:0002673
MousePhenoabnormal male germ cell morphology

FSIP2 UBR2 DDIAS GK GK2 FSIP1 ASPM JMJD1C

1.53e-04859278MP:0006362
MousePhenoabnormal spermatogenesis

FSIP2 UBR2 DDIAS GK GK2 FSIP1 ASPM JMJD1C

2.28e-04910278MP:0001156
MousePhenoabnormal germ cell morphology

FSIP2 UBR2 DDIAS GK GK2 FSIP1 ASPM JMJD1C

2.98e-04946278MP:0002208
MousePhenoabnormal foam cell morphology

FSIP2 UBR2 DDIAS GK GK2 FSIP1 ASPM JMJD1C

3.15e-04954278MP:0009840
MousePhenoabnormal gametes

FSIP2 UBR2 GK GK2 FSIP1 ASPM JMJD1C

5.66e-04785277MP:0001124
MousePhenoabnormal male reproductive system physiology

FSIP2 UBR2 GK GK2 CLCN3 FSIP1 ASPM CDC34 JMJD1C

5.94e-041329279MP:0003698
MousePhenoabnormal gametogenesis

FSIP2 UBR2 DDIAS GK GK2 FSIP1 ASPM JMJD1C

6.83e-041070278MP:0001929
MousePhenoabnormal sperm motility

FSIP2 GK GK2 FSIP1 ASPM

9.08e-04401275MP:0002674
MousePhenoteratozoospermia

FSIP2 GK GK2 FSIP1 ASPM

9.81e-04408275MP:0005578
DomainRabGAP-TBC

TBC1D3E TBC1D3H TBC1D3L TBC1D3D TBC1D28 TBC1D3I TBC1D3G TBC1D3C TBC1D3B TBC1D26 TBC1D3K TBC1D3F

4.61e-21534812PF00566
DomainTBC_RABGAP

TBC1D3E TBC1D3H TBC1D3L TBC1D3D TBC1D28 TBC1D3I TBC1D3G TBC1D3C TBC1D3B TBC1D26 TBC1D3K TBC1D3F

7.55e-21554812PS50086
DomainRab-GTPase-TBC_dom

TBC1D3E TBC1D3H TBC1D3L TBC1D3D TBC1D28 TBC1D3I TBC1D3G TBC1D3C TBC1D3B TBC1D26 TBC1D3K TBC1D3F

7.55e-21554812IPR000195
DomainTBC

TBC1D3E TBC1D3H TBC1D3L TBC1D3D TBC1D3I TBC1D3G TBC1D3C TBC1D3B TBC1D26 TBC1D3K TBC1D3F

2.55e-19494811SM00164
DomainArp1

ACTR1B ACTR1A

6.47e-062482IPR029909
DomainCarb_kinase_FGGY_CS

GK GK2

1.94e-053482IPR018483
DomainGlycerol_kin

GK GK2

3.87e-054482IPR005999
DomainFGGY_KINASES_2

GK GK2

6.44e-055482PS00445
DomainFGGY_KINASES_1

GK GK2

6.44e-055482PS00933
DomainCarb_kinase_FGGY_C

GK GK2

6.44e-055482IPR018485
DomainFGGY_C

GK GK2

9.64e-056482PF02782
DomainCarb_kinase_FGGY_N

GK GK2

9.64e-056482IPR018484
DomainCarb_kinase_FGGY

GK GK2

1.35e-047482IPR000577
DomainFGGY_N

GK GK2

1.35e-047482PF00370
DomainActin_CS

ACTR1B ACTR1A

7.58e-0416482IPR004001
DomainACTINS_2

ACTR1B ACTR1A

8.58e-0417482PS00432
DomainActin/actin-like_CS

ACTR1B ACTR1A

9.64e-0418482IPR020902
DomainACTINS_ACT_LIKE

ACTR1B ACTR1A

1.08e-0319482PS01132
DomainActin

ACTR1B ACTR1A

2.87e-0331482IPR004000
DomainActin

ACTR1B ACTR1A

2.87e-0331482PF00022
DomainACTIN

ACTR1B ACTR1A

2.87e-0331482SM00268
PathwayWP_17Q12_COPY_NUMBER_VARIATION_SYNDROME

TBC1D3E TBC1D3 TBC1D3H TBC1D3L TBC1D3I TBC1D3G TBC1D3C TBC1D3B TBC1D3K

1.30e-1299349M46448
PathwayWP_TRIACYLGLYCERIDE_SYNTHESIS

GK GK2 LPL GPAM

2.42e-0723344MM15890
PathwayWP_TRIACYLGLYCERIDE_SYNTHESIS

GK GK2 LPL GPAM

2.90e-0724344M39692
PathwayREACTOME_TRIGLYCERIDE_BIOSYNTHESIS

GK GK2 GPAM

2.78e-0612343MM15447
PathwayREACTOME_TRIGLYCERIDE_BIOSYNTHESIS

GK GK2 GPAM

4.58e-0614343M619
PathwayKEGG_GLYCEROLIPID_METABOLISM

GK GK2 LPL GPAM

5.53e-0649344M15902
PathwayKEGG_PPAR_SIGNALING_PATHWAY

GK GK2 LPL SORBS1

2.18e-0569344M13088
PathwayREACTOME_TRIGLYCERIDE_METABOLISM

GK GK2 GPAM

2.20e-0523343MM15575
PathwayWP_PPAR_SIGNALING_PATHWAY

GK GK2 LPL SORBS1

2.73e-0573344MM15995
PathwayWP_FATTY_ACID_BETAOXIDATION

GK GK2 LPL

7.29e-0534343M39596
PathwayWP_FATTY_ACID_BETAOXIDATION

GK GK2 LPL

7.29e-0534343MM15937
PathwayREACTOME_TRIGLYCERIDE_METABOLISM

GK GK2 GPAM

1.02e-0438343M27856
PathwayWP_PPAR_SIGNALING

GK2 LPL SORBS1

5.53e-0467343M39553
PathwayWP_GLYCEROLIPIDS_AND_GLYCEROPHOSPHOLIPIDS

GPAM PLD1

1.27e-0322342M39362
PathwayWP_GLYCEROLIPIDS_AND_GLYCEROPHOSPHOLIPIDS

GPAM PLD1

1.38e-0323342MM15993
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_SOD1_TO_RETROGRADE_AXONAL_TRANSPORT

ACTR1B ACTR1A

1.91e-0327342M47755
PathwayWP_GLYCEROPHOSPHOLIPID_BIOSYNTHETIC_PATHWAY

GK GPAM

2.35e-0330342M39592
Pubmed

TBC1D3, a hominoid oncoprotein, is encoded by a cluster of paralogues located on chromosome 17q12.

TBC1D3E TBC1D3 TBC1D3H TBC1D3L TBC1D3D TBC1D3I TBC1D3G TBC1D3C TBC1D3B TBC1D3K TBC1D3F

3.38e-3211531116863688
Pubmed

DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

TBC1D3E TBC1D3 TBC1D3H TBC1D3D TBC1D3G TBC1D3B TBC1D3F

2.10e-117453716625196
Pubmed

Identification of novel sequences in the repertoire of hypervariable TRE17 genes from immortalized nonmalignant and malignant human keratinocytes.

TBC1D3 TBC1D3D TBC1D3F

1.34e-0845338406013
Pubmed

PRC17, a novel oncogene encoding a Rab GTPase-activating protein, is amplified in prostate cancer.

TBC1D3 TBC1D3D TBC1D3F

1.34e-08453312359748
Pubmed

The Tre2 (USP6) oncogene is a hominoid-specific gene.

TBC1D3 TBC1D3D TBC1D3C

3.33e-08553312604796
Pubmed

Human TRE17 oncogene is generated from a family of homologous polymorphic sequences by single-base changes.

TBC1D3 TBC1D3D TBC1D3F

3.33e-0855338471161
Pubmed

Glycerol kinase 2 is essential for proper arrangement of crescent-like mitochondria to form the mitochondrial sheath during mouse spermatogenesis.

GK GK2

2.28e-06253230662012
Pubmed

Beta-centractin: characterization and distribution of a new member of the centractin family of actin-related proteins.

ACTR1B ACTR1A

2.28e-0625327696711
Pubmed

Glycerol kinase-like proteins cooperate with Pld6 in regulating sperm mitochondrial sheath formation and male fertility.

GK GK2

6.83e-06353228852571
Pubmed

Diversity of human copy number variation and multicopy genes.

TBC1D3E TBC1D3G

6.83e-06353221030649
Pubmed

Validation of candidate causal genes for obesity that affect shared metabolic pathways and networks.

GK LPL

2.27e-05553219270708
Pubmed

A-kinase anchoring protein 4 binding proteins in the fibrous sheath of the sperm flagellum.

FSIP2 FSIP1

2.27e-05553212606363
Pubmed

The glycerol kinase gene family: structure of the Xp gene, and related intronless retroposons.

GK GK2

2.27e-0555327987308
Pubmed

Identification and characterization of a novel Tre-2/Bub2/Cdc16 (TBC) protein that possesses Rab3A-GAP activity.

TBC1D3 TBC1D26 TBC1D3F

3.95e-054353319077034
Pubmed

Retrotransposition of glycerol kinase-related genes from the X chromosome to autosomes: functional and evolutionary aspects.

GK GK2

4.76e-05753210444329
Pubmed

Interactions between the evolutionarily conserved, actin-related protein, Arp11, actin, and Arp1.

ACTR1B ACTR1A

4.76e-05753212857853
Pubmed

A Cellular Mechanism to Detect and Alleviate Reductive Stress.

FLCN CDC34

8.15e-05953232941802
Pubmed

Structural basis and regulation of the reductive stress response.

FLCN CDC34

1.02e-041053234562363
Pubmed

Mutations in the Cacnl1a4 calcium channel gene are associated with seizures, cerebellar degeneration, and ataxia in tottering and leaner mutant mice.

LPL RFX1

1.02e-04105329060410
Pubmed

Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.

RGSL1 TBC1D3 CLCN3 TBC1D3D GPAM SORBS1 TBC1D3F

1.37e-0475053711230166
Pubmed

Positional cloning of Sorcs1, a type 2 diabetes quantitative trait locus.

GPAM XPNPEP1

2.05e-041453216682971
Pubmed

Mapping genetic loci that regulate lipid levels in a NZB/B1NJxRF/J intercross and a combined intercross involving NZB/B1NJ, RF/J, MRL/MpJ, and SJL/J mouse strains.

GK2 GPAM

3.05e-041753217496333
Pubmed

Animal Models of Congenital Cardiomyopathies Associated With Mutations in Z-Line Proteins.

OBSCN NEB

3.83e-041953227171814
Pubmed

Vif hijacks CBF-β to degrade APOBEC3G and promote HIV-1 infection.

UBR2 CDC34

4.70e-042153222190037
Pubmed

Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

OBSCN GPAM CWC22

5.01e-0410153310997877
Pubmed

Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations.

GK LPL GPAM SORBS1

5.79e-0425053418660489
Pubmed

Blood pressure is regulated by an alpha1D-adrenergic receptor/dystrophin signalosome.

DTNA NEB

7.80e-042753218468998
Pubmed

Biosynthesis of triacylglycerols.

GK GPAM

8.40e-04285328944226
Pubmed

An improved smaller biotin ligase for BioID proximity labeling.

FSIP2 CCDC168 JMJD1C

8.89e-0412353326912792
Pubmed

A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.

DTNA OBSCN SORBS1 NEB JMJD1C

9.53e-0449753523414517
Pubmed

Forty-three loci associated with plasma lipoprotein size, concentration, and cholesterol content in genome-wide analysis.

LPL JMJD1C

9.64e-043053219936222
Pubmed

GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer.

TBC1D3 TBC1D3F

1.10e-033253223535730
Pubmed

ATPase-Modulated Stress Granules Contain a Diverse Proteome and Substructure.

ACTR1B ACTR1A SORBS1 CWC22

1.36e-0331553426777405
Pubmed

Biological, clinical and population relevance of 95 loci for blood lipids.

LPL GPAM JMJD1C

1.46e-0314653320686565
Pubmed

The conserved Mediator subunit cyclin C (CCNC) is required for brown adipocyte development and lipid accumulation.

LPL GPAM

1.47e-033753235863637
InteractionCLIC3 interactions

TBC1D3 RFX1 TBC1D3C TBC1D3K

1.79e-0563504int:CLIC3
CytobandEnsembl 112 genes in cytogenetic band chr17q12

TBC1D3E TBC1D3 TBC1D3H TBC1D3L TBC1D3D TBC1D3I TBC1D3G TBC1D3C TBC1D3B TBC1D3K TBC1D3F

1.96e-171495311chr17q12
Cytoband17q12

TBC1D3 TBC1D3H TBC1D3C TBC1D3B TBC1D3F

1.11e-079953517q12
Cytoband17p11.2

TBC1D28 FLCN TBC1D26

8.41e-0415953317p11.2
GeneFamilyGlycerol kinases

GK GK2

2.31e-056232568
CoexpressionNAKAYA_B_CELL_FLUARIX_FLUVIRIN_AGE_18_50YO_7DY_UP

GK TBC1D3 CLCN3 TBC1D3H SIGLEC6 TBC1D3C TBC1D3F

5.16e-06367497M41159
CoexpressionHOEK_MYELOID_DENDRITIC_CELL_2011_2012_TIV_ADULT_7DY_UP

SIGLEC6 LPL B3GNT7

1.74e-0527493M41009
CoexpressionGSE36888_UNTREATED_VS_IL2_TREATED_TCELL_2H_DN

FAIM CLCN3 LPL PPM1E ASPM

3.49e-05199495M8736
CoexpressionAtlasMesoderm Day 15_vs_Mesoderm Day 30-Confounder_removed-fold2.0_adjp0.05

TBC1D3 TBC1D3H TBC1D3L TBC1D3D TBC1D3G TBC1D3C TBC1D3B TBC1D3K TBC1D3F

1.11e-1290539PCBC_ratio_MESO-15_vs_MESO-30_cfr-2X-p05
CoexpressionAtlasEndoderm Differentiated Cells-reprogram_OSKM-L_vs_Endoderm Differentiated Cells-reprogram_NA-Confounder_removed-fold2.0_adjp0.05

TBC1D3 TBC1D3H TBC1D3L TBC1D3D TBC1D3G TBC1D3C TBC1D3B TBC1D3K TBC1D3F

2.63e-09213539PCBC_ratio_DE_from-OSKM-L_vs_DE_from-ESC_cfr-2X-p05
CoexpressionAtlasEndoderm Differentiated Cells-method_mRNA_vs_Endoderm Differentiated Cells-method_NA-Confounder_removed-fold2.0_adjp0.05

TBC1D3 TBC1D3H TBC1D3L TBC1D3D TBC1D3G TBC1D3C TBC1D3B TBC1D3K TBC1D3F

2.63e-09213539PCBC_ratio_DE_from-mRNA_vs_DE_from-ESC_cfr-2X-p05
CoexpressionAtlasDE cord blood_vs_DE blastocyst-Confounder_removed-fold2.0_adjp0.05

TBC1D3 TBC1D3H TBC1D3L TBC1D3D TBC1D3G TBC1D3C TBC1D3B TBC1D3K TBC1D3F

8.01e-09242539PCBC_ratio_DE cord blood_vs_DE blastocyst_cfr-2X-p05
CoexpressionAtlasMesoderm Day 5-reprogram_OSKM-L_vs_Mesoderm Day 5-reprogram_NA-Confounder_removed-fold2.0_adjp0.05

TBC1D3 TBC1D3H TBC1D3L TBC1D3D TBC1D3G TBC1D3C TBC1D3B TBC1D3K TBC1D3F

2.92e-08281539PCBC_ratio_MESO-5_from-OSKM-L_vs_MESO-5_from-ESC_cfr-2X-p05
CoexpressionAtlasMesoderm Day 5-method_mRNA_vs_Mesoderm Day 5-method_NA-Confounder_removed-fold2.0_adjp0.05

TBC1D3 TBC1D3H TBC1D3L TBC1D3D TBC1D3G TBC1D3C TBC1D3B TBC1D3K TBC1D3F

2.92e-08281539PCBC_ratio_MESO-5_from-mRNA_vs_MESO-5_from-ESC_cfr-2X-p05
CoexpressionAtlasMesoderm Day 5_vs_Endoderm Differentiated Cells-Confounder_removed-fold2.0_adjp0.05

TBC1D3 TBC1D3H TBC1D3L TBC1D3D TBC1D3G TBC1D3C TBC1D3B TBC1D3K TBC1D3F

8.87e-08320539PCBC_ratio_MESO-5_vs_DE_cfr-2X-p05
CoexpressionAtlasMesoderm Day 15_vs_Mesoderm Day 5-Confounder_removed-fold2.0_adjp0.05

TBC1D3 CLCN3 TBC1D3H TBC1D3L TBC1D3D GPAM TBC1D3G TBC1D3C TBC1D3B TBC1D3K TBC1D3F

4.58e-0510495311PCBC_ratio_MESO-15_vs_MESO-5_cfr-2X-p05
CoexpressionAtlasMesoderm Day 5_vs_Pluripotent Stem Cells-Confounder_removed-fold2.0_adjp0.05

FOXJ2 TBC1D3 TBC1D3H TBC1D3L TBC1D3D DTNA TBC1D3G TBC1D3C TBC1D3B TBC1D3K TBC1D3F

1.07e-0411535311PCBC_ratio_MESO-5_vs_SC_cfr-2X-p05
CoexpressionAtlasEctoderm Differentiated Cells_vs_Endoderm Differentiated Cells-Confounder_removed-fold2.0_adjp0.05

ACTR1B TBC1D3 TBC1D3H TBC1D3L TBC1D3D TBC1D3G TBC1D3C TBC1D3B TBC1D3K TBC1D3F

2.83e-0410755310PCBC_ratio_ECTO_vs_DE_cfr-2X-p05
ToppCellLA-03._Atrial_Cardiomyocyte|World / Chamber and Cluster_Paper

DTNA PPM1E OBSCN SORBS1 NEB

2.95e-061885356d249fe92d51a19da19ec14bb2262d394255d577
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c04-ANXA2|Severe-critical_progression_d12-22 / Compartment, severity and other cell annotations on 10x 3' data (130k)

DTNA ASPM GPAM SORBS1

4.23e-05163534ce07bc424ef99c547588b07f5c8b39ff0773ca9b
ToppCellCOVID-19-Heart-CM_+_Macrophage|COVID-19 / Disease (COVID-19 only), tissue and cell type

DTNA LPL OBSCN SORBS1

4.99e-051705343f15242a1d3e4e9871d9170b2ef05842fb609c29
ToppCellPND07-Immune-Immune_Myeloid-Monocytic-Macrophage-AM-AM_G2M|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

DDIAS LPL ASPM B3GNT7

5.10e-05171534845f312f8cbe29d820da25f0e6d75deb382bbfd8
ToppCellCOVID-19-Heart-CM_3|COVID-19 / Disease (COVID-19 only), tissue and cell type

DTNA LPL OBSCN SORBS1

5.71e-051765349df7a124ebafb0087da0cda133a394275d7bed81
ToppCellCOVID-19-Heart-CM_+_EC_+_Pericyte|COVID-19 / Disease (COVID-19 only), tissue and cell type

DTNA LPL OBSCN SORBS1

6.36e-05181534719eb532453ab7cd7893726885bc75d74a10b21e
ToppCellCOVID-19-Heart-CM_3|Heart / Disease (COVID-19 only), tissue and cell type

DTNA LPL OBSCN SORBS1

6.50e-05182534287fcc3897ae08841f6f85ae6c9cef16f75b1dd1
ToppCellLV-15._Ventricular_Cardiomyocyte_III|LV / Chamber and Cluster_Paper

DTNA LPL OBSCN SORBS1

6.78e-05184534ab7a1620c14a9d9b6be1b47c559931e345e9eef8
ToppCellCOVID-19-Heart-CM_2|COVID-19 / Disease (COVID-19 only), tissue and cell type

DTNA LPL OBSCN SORBS1

6.92e-05185534549eeb521c3985bff396ea0f202db21822efa51f
ToppCellLV-15._Ventricular_Cardiomyocyte_III|World / Chamber and Cluster_Paper

DTNA LPL OBSCN SORBS1

6.92e-051855346baccb26f999145e51b91d94315bf8d4655bef31
ToppCellRV-06._Ventricular_Cardiomyocyte_II|World / Chamber and Cluster_Paper

DTNA LPL OBSCN SORBS1

7.52e-051895345e80c47f63980904c4c1ff02c201b67b456a0974
ToppCellCOVID-19-Heart|COVID-19 / Disease (COVID-19 only), tissue and cell type

DTNA LPL OBSCN SORBS1

7.68e-05190534918ad5037881212008f9f69d5df5da91fd01422c
ToppCellCOVID-19-Heart-CM_4|Heart / Disease (COVID-19 only), tissue and cell type

FAM153B GK FAM153A DTNA

7.68e-051905343729648a17093b438398b82e32bbccc3af7b8c5d
ToppCellCOVID-19-Heart-CM_+_EC_+_Pericyte|Heart / Disease (COVID-19 only), tissue and cell type

DTNA LPL OBSCN SORBS1

8.15e-05193534dd5378a1ef8eb0eda9a3aae62f3c2f3a1402bda0
ToppCellCOVID-19-Heart-CM_1|Heart / Disease (COVID-19 only), tissue and cell type

DTNA LPL OBSCN SORBS1

8.49e-05195534f1ef50331eda8f1239dba6ea970df4eaccf032f1
ToppCellCOVID-19-Heart-CM_2|Heart / Disease (COVID-19 only), tissue and cell type

DTNA LPL OBSCN SORBS1

8.49e-0519553475fc81bddb246dca3b437fb60827b1d4fe416405
ToppCellTracheal-NucSeq-Stromal-Myofibroblastic-Muscle_smooth_airway_ASM|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

FAM153B FAM153A DTNA SORBS1

9.00e-0519853422e766df1276c5b14aa0d83f434f47140ebb98ea
ToppCellcontrol-unassigned|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

FAM153B FAM153A CLCN3 FSIP1

9.18e-0519953450e2da35edff1aadef939cfbd4549f73c1a07717
ToppCellcontrol-unassigned|control / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

FAM153B FAM153A CLCN3 FSIP1

9.18e-051995345db7c8089172ac8e796613b3cef618d87007a0ab
ToppCellStriatum-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Drd1-Excitatory_Neuron.Gad1Gad2.Drd1-Nfib_(Amygdala)-|Striatum / BrainAtlas - Mouse McCarroll V32

RGSL1 OBSCN NEB

1.28e-04825331ca848a18463b1344e23e3ad1b5d01ae27c00586
ToppCellStriatum-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Drd1-Excitatory_Neuron.Gad1Gad2.Drd1-Nfib_(Amygdala)|Striatum / BrainAtlas - Mouse McCarroll V32

RGSL1 OBSCN NEB

1.28e-0482533ab081620b6113f843fede23da0a18720111ffc7c
ComputationalNeighborhood of DMPK

ZNF132 CLCN3 PPM1E NEB

3.95e-04175224MORF_DMPK
ComputationalNeighborhood of PRKCA

ZNF132 CLCN3 PPM1E NEB

4.49e-04181224MORF_PRKCA
ComputationalNeighborhood of MAP2K7

ZNF132 CLCN3 PPM1E NEB

4.49e-04181224MORF_MAP2K7
ComputationalNeighborhood of CTSB

ZNF132 CLCN3 PPM1E NEB

5.08e-04187224MORF_CTSB
ComputationalNeighborhood of IFNA1

ZNF132 CLCN3 PPM1E NEB

7.18e-04205224MORF_IFNA1
ComputationalNeighborhood of PTPRR

ZNF132 CLCN3 NEB

1.12e-03102223MORF_PTPRR
ComputationalNeighborhood of PTPRB

ZNF132 CLCN3 PPM1E NEB

1.59e-03254224MORF_PTPRB
ComputationalNeighborhood of MAGEA8

ZNF132 CLCN3 PPM1E NEB

1.74e-03260224MORF_MAGEA8
ComputationalNeighborhood of FSHR

ZNF132 CLCN3 PPM1E NEB

2.25e-03279224MORF_FSHR
ComputationalNeighborhood of CDH4

ZNF132 PPM1E NEB

2.56e-03136223MORF_CDH4
ComputationalNeighborhood of CAMK4

ZNF132 CLCN3 PPM1E NEB

2.59e-03290224MORF_CAMK4
ComputationalNeighborhood of MLLT10

ZNF132 CLCN3 PPM1E NEB

2.99e-03302224MORF_MLLT10
ComputationalNeighborhood of SUPT3H

ZNF132 CLCN3 PPM1E NEB

4.03e-03328224MORF_SUPT3H
ComputationalNeighborhood of ATF2

ZNF132 CLCN3 PPM1E NEB

4.12e-03330224MORF_ATF2
Drugdihydrocytochalasin B

ACTR1B ACTR1A GPAM PLD1

5.71e-0658464CID000003064
Diseaseglycerol kinase deficiency (implicated_via_orthology)

GK GK2

5.93e-063422DOID:0060363 (implicated_via_orthology)
Diseasecholesteryl esters to total lipids in IDL percentage

LPL GPAM JMJD1C

5.02e-0550423EFO_0022247
Diseasecholesterol in IDL measurement

LPL GPAM JMJD1C

7.83e-0558423EFO_0021899
Diseasetotal lipids in IDL

LPL GPAM JMJD1C

8.67e-0560423EFO_0022161
Diseasecholesterol to total lipids in IDL percentage

LPL GPAM JMJD1C

8.67e-0560423EFO_0022233
Diseasefree cholesterol in IDL measurement

LPL GPAM JMJD1C

9.11e-0561423EFO_0022181
Diseasetriglycerides to total lipids in IDL percentage

LPL GPAM JMJD1C

1.00e-0463423EFO_0022329
Diseasephospholipids:total lipids ratio, intermediate density lipoprotein measurement

LPL GPAM JMJD1C

1.21e-0467423EFO_0008595, EFO_0020946
Diseasetriglycerides to phosphoglycerides ratio

LPL GPAM JMJD1C

1.26e-0468423EFO_0022327
Diseasetriglycerides to total lipids in very small VLDL percentage

LPL GPAM JMJD1C

1.32e-0469423EFO_0022341
Diseasefree cholesterol to total lipids in large LDL percentage

LPL GPAM JMJD1C

1.62e-0474423EFO_0022280
Diseasemonounsaturated fatty acids; 16:1, 18:1 measurement

LPL GPAM JMJD1C

1.89e-0478423EFO_0022187
Diseasecholesteryl ester measurement, intermediate density lipoprotein measurement

LPL GPAM JMJD1C

3.28e-0494423EFO_0008595, EFO_0010351
Diseaselipid measurement, intermediate density lipoprotein measurement

LPL GPAM JMJD1C

3.49e-0496423EFO_0004529, EFO_0008595
DiseaseCCL4 measurement

TBC1D3 TBC1D3F

3.70e-0420422EFO_0004751
Diseasetotal cholesterol measurement, intermediate density lipoprotein measurement

LPL GPAM JMJD1C

3.82e-0499423EFO_0004574, EFO_0008595
Diseasedocosahexaenoic acid to total fatty acids percentage

LPL JMJD1C

4.08e-0421422EFO_0022262
Diseasecholesteryl esters:total lipids ratio, intermediate density lipoprotein measurement

LPL GPAM JMJD1C

4.30e-04103423EFO_0008595, EFO_0020944
Diseasefree cholesterol measurement, intermediate density lipoprotein measurement

LPL GPAM JMJD1C

4.42e-04104423EFO_0008591, EFO_0008595
Diseasecholesterol:total lipids ratio, intermediate density lipoprotein measurement

LPL GPAM JMJD1C

6.87e-04121423EFO_0008595, EFO_0020943
Diseasetriglycerides:total lipids ratio, intermediate density lipoprotein measurement

LPL GPAM JMJD1C

7.91e-04127423EFO_0008595, EFO_0020947
Diseasecholesteryl esters to total lipids in large LDL percentage

LPL JMJD1C

8.96e-0431422EFO_0022249
Diseasemacrophage inflammatory protein 1b measurement

TBC1D3 TBC1D3B TBC1D3F

9.64e-04136423EFO_0008219
Diseasefree cholesterol measurement, low density lipoprotein cholesterol measurement

LPL GPAM JMJD1C

9.85e-04137423EFO_0004611, EFO_0008591
Diseasetriglyceride measurement, physical activity

LPL JMJD1C

1.08e-0334422EFO_0003940, EFO_0004530
Diseasetriglyceride measurement, phospholipid measurement

LPL GPAM JMJD1C

1.18e-03146423EFO_0004530, EFO_0004639
Diseasenon-alcoholic fatty liver disease (implicated_via_orthology)

UBR2 LPL

1.21e-0336422DOID:0080208 (implicated_via_orthology)
Diseasetriglycerides:total lipids ratio, low density lipoprotein cholesterol measurement

LPL GPAM JMJD1C

1.28e-03150423EFO_0004611, EFO_0020947
Diseasedegree of unsaturation measurement

LPL JMJD1C

1.42e-0339422EFO_0022261
Diseasedocosahexaenoic acid measurement, fatty acid measurement

LPL JMJD1C

1.49e-0340422EFO_0005110, EFO_0007761
Diseasecholesterol to total lipids in large VLDL percentage

LPL JMJD1C

1.88e-0345422EFO_0022236
Diseasecholesteryl esters to total lipids in small VLDL percentage

LPL JMJD1C

2.23e-0349422EFO_0022256
Diseasetriglycerides to total lipids in medium LDL percentage

LPL JMJD1C

2.32e-0350422EFO_0022334
Diseasepolyunsaturated fatty acids to total fatty acids percentage

LPL JMJD1C

2.32e-0350422EFO_0022303
Diseasetriglycerides to total lipids in large LDL percentage

LPL JMJD1C

2.41e-0351422EFO_0022331
Diseasefree cholesterol in large LDL measurement

LPL JMJD1C

2.41e-0351422EFO_0022176
Diseasepolyunsaturated fatty acids to monounsaturated fatty acids ratio

LPL JMJD1C

2.41e-0351422EFO_0022302
Diseasecholesterol to total lipids in small VLDL percentage

LPL JMJD1C

2.41e-0351422EFO_0022242
Diseasetriglycerides to total lipids in very large VLDL percentage

LPL JMJD1C

2.60e-0353422EFO_0022340
Diseasefree cholesterol to total lipids in small LDL percentage

LPL JMJD1C

2.60e-0353422EFO_0022286

Protein segments in the cluster

PeptideGeneStartEntry
ILASLDTFKKMWVSK

ACTR1B

346

P42025
KSSTLIIQSMFRKWK

ASPM

1421

Q8IZT6
WLSALTFKTLERMKK

OVOS1

851

Q6IE37
KFWMTGLSKTYKSHL

FLCN

551

Q8NFG4
SEIRYSTWKKAVMKS

GK3P

496

Q14409
RYDKKYSWDVKSLVM

PUDP

36

Q08623
ERKSSRDKELYAWMK

JMJD1C

1876

Q15652
SMRAASLKDKWGLSY

KIAA1109

3596

Q2LD37
SLAYQRMSWEALKKS

CWC22

151

Q9HCG8
KTWFDSEKKMKYLSL

FSIP2

1221

Q5CZC0
SEEKMSVSTWSRKKY

FSIP2

3466

Q5CZC0
ELLMLKLKWKSDSYF

LPL

401

P06858
WSLVSYMDKKSTAEK

DDIAS

296

Q8IXT1
STWKKYQEAMKTSLG

FAM153A

26

Q9UHL3
IKFWTAMFSDKKYLT

PI4KAP1

151

Q8N8J0
SSPAKKMTLSEIYRW

FOXJ2

81

Q9P0K8
LSWSFRNLYKSMLEK

FOXJ2

251

Q9P0K8
SWKGYSENMRKLRKT

PPM1E

726

Q8WY54
TEVMWYKDGKKLSSS

OBSCN

1011

Q5VST9
SEIRYATWKKAVMKS

GK2

496

Q14410
LKKYMEDRSKTTNTW

FAIM

86

Q9NVQ4
ESEIRYSTWKKAVMK

GK

501

P32189
ILASLDTFKKMWVSK

ACTR1A

346

P61163
MKEYTSWKSPAKKLT

DTNA

286

Q9Y4J8
MRIKLWEEIKSAKYS

FSIP1

146

Q8NA03
KYRSSSKMKSPDWLC

CCDC168

6866

Q8NDH2
MSLWKKTVYRSLCLA

B3GNT7

1

Q8NFL0
LYSTWKKYQEAMKTS

FAM153B

101

P0C7A2
YSSRKAKRKMWQLVD

RGSL1

246

A5PLK6
WNFTKIMKSKYRSLS

PLD1

701

Q13393
AKLFLLKWSFYSSMV

RFX1

846

P22670
LQYYTWSEKKMELSK

TAF1A

186

Q15573
SATLKWKESLMSRKR

GPAM

46

Q9HCL2
KWMKYGYTSSKLSVR

SIGLEC6

126

O43699
MLADWTKYRSTKKLS

TBC1D26

81

Q86UD7
MLGDWEKYKSSRKLI

TBC1D3L

81

B9A6J9
IKFWTAMFSDKKYLT

PI4KAP2

151

A4QPH2
KKESAWEMTKSLYDA

CLCN3

111

P51790
KESMWYRKLKVFSGT

PNMA5

151

Q96PV4
MLGDWEKYKSSRKLI

TBC1D3B

81

A6NDS4
MLGDWEKYKSSRKLI

TBC1D3H

81

P0C7X1
RWYKDRDALMKSSKV

ZNF132

171

P52740
KSWMNLKSISPSYKT

TTC13

816

Q8NBP0
TDYWKKMAKVLRSAG

XPNPEP1

126

Q9NQW7
NVDASVMYRKWKESK

CDC34

141

P49427
MLGDWEKYKSSRKLI

TBC1D3F

81

A6NER0
RNTERSKDWYKTMFK

SORBS1

386

Q9BX66
MLGDWEKYKSSRKLI

TBC1D3E

81

A0A087X179
MLADWTKYRSTKKLS

TBC1D28

81

Q2M2D7
MLGDWEKYKSSRKLI

TBC1D3D

81

A0A087WVF3
MLSDSKLWKGARSVY

UBR2

356

Q8IWV8
MLGDWEKYKSSRKLI

TBC1D3G

81

Q6DHY5
MLGDWEKYKSSRKLI

TBC1D3

81

Q8IZP1
MLGDWEKYKSSRKLI

TBC1D3K

81

A0A087X1G2
MLGDWEKYKSSRKLI

TBC1D3I

81

A0A087WXS9
MLGDWEKYKSSRKLI

TBC1D3C

81

Q6IPX1
KRWAMKVFSSLKSNE

NLRP14

346

Q86W24
MNKRLYTEAWDKDKT

NEB

2961

P20929