Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	atrial septum secundum morphogenesis	NSD2 GATA4	6.73e-06	2	54	2	GO:0003290
GeneOntologyBiologicalProcess	negative regulation of organelle organization	SPTBN5 FZD9 TBC1D4 XRN1 NUBP1 RNF41 SSH2 WDR47	1.29e-05	421	54	8	GO:0010639
GeneOntologyBiologicalProcess	septum secundum development	NSD2 GATA4	2.01e-05	3	54	2	GO:0003285
GeneOntologyBiologicalProcess	atrial septum primum morphogenesis	NSD2 GATA4	6.69e-05	5	54	2	GO:0003289
GeneOntologyBiologicalProcess	septum primum development	NSD2 GATA4	1.00e-04	6	54	2	GO:0003284
GeneOntologyBiologicalProcess	actin filament-based process	SPTBN5 KCNC3 INF2 ARHGEF5 MYO19 IQSEC2 GATA4 SSH2 PLS1 PLS3	1.11e-04	912	54	10	GO:0030029
GeneOntologyBiologicalProcess	regulation of organelle organization	SPTBN5 FZD9 TBC1D4 INF2 ARHGEF5 MYO19 XRN1 NUBP1 RNF41 SSH2 CLIP1 WDR47	1.46e-04	1342	54	12	GO:0033043
GeneOntologyBiologicalProcess	actin cytoskeleton organization	SPTBN5 KCNC3 INF2 ARHGEF5 MYO19 IQSEC2 SSH2 PLS1 PLS3	2.17e-04	803	54	9	GO:0030036
GeneOntologyBiologicalProcess	actin filament organization	SPTBN5 INF2 ARHGEF5 MYO19 SSH2 PLS1 PLS3	3.47e-04	509	54	7	GO:0007015
GeneOntologyBiologicalProcess	actin filament network formation	PLS1 PLS3	3.64e-04	11	54	2	GO:0051639
GeneOntologyBiologicalProcess	negative regulation of cellular component organization	XYLT1 SPTBN5 FZD9 TBC1D4 XRN1 NUBP1 RNF41 SSH2 WDR47	3.72e-04	864	54	9	GO:0051129
GeneOntologyCellularComponent	cell cortex	SPTBN5 DST KCNC3 GUCY1B1 IQSEC2 CLIP1 PLS1	5.75e-05	371	56	7	GO:0005938
GeneOntologyCellularComponent	actin cytoskeleton	SPTBN5 DST ACACA INF2 ARHGEF5 MYO19 PLS1 PLS3	1.40e-04	576	56	8	GO:0015629
GeneOntologyCellularComponent	cell cortex region	SPTBN5 GUCY1B1 IQSEC2	2.39e-04	45	56	3	GO:0099738
Domain	Actinin_actin-bd_CS	SPTBN5 DST PLS1 PLS3	5.72e-07	23	55	4	IPR001589
Domain	ACTININ_2	SPTBN5 DST PLS1 PLS3	5.72e-07	23	55	4	PS00020
Domain	ACTININ_1	SPTBN5 DST PLS1 PLS3	5.72e-07	23	55	4	PS00019
Domain	ARHGEF5_35	ARHGEF35 ARHGEF5	8.51e-06	2	55	2	PF15441
Domain	ARHGEF5/35_N	ARHGEF35 ARHGEF5	8.51e-06	2	55	2	IPR029212
Domain	CH	SPTBN5 DST PLS1 PLS3	3.99e-05	65	55	4	SM00033
Domain	CH	SPTBN5 DST PLS1 PLS3	5.34e-05	70	55	4	PF00307
Domain	-	SPTBN5 DST PLS1 PLS3	5.65e-05	71	55	4	1.10.418.10
Domain	CH	SPTBN5 DST PLS1 PLS3	6.30e-05	73	55	4	PS50021
Domain	CH-domain	SPTBN5 DST PLS1 PLS3	7.00e-05	75	55	4	IPR001715
Domain	EF-hand_7	DST PLS1 PLS3	2.01e-03	85	55	3	PF13499
Domain	Spectrin	SPTBN5 DST	2.07e-03	23	55	2	PF00435
Domain	PID	TBC1D4 ANKS1A	3.06e-03	28	55	2	PF00640
Domain	Spectrin_repeat	SPTBN5 DST	3.29e-03	29	55	2	IPR002017
Domain	Spectrin/alpha-actinin	SPTBN5 DST	3.99e-03	32	55	2	IPR018159
Domain	PID	TBC1D4 ANKS1A	3.99e-03	32	55	2	PS01179
Domain	SPEC	SPTBN5 DST	3.99e-03	32	55	2	SM00150
Pubmed	E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.	TRMT6 TBC1D4 DST ACACA DQX1 SRGAP3 MYO19 CLNS1A IQSEC2 PLS1	2.98e-07	736	57	10	29676528
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	TBC1D4 DST ACACA ARHGEF5 IQSEC2 XRN1 SIK2 LMTK2 SSH2 ANKS1A	1.24e-06	861	57	10	36931259
Pubmed	Comprehensive characterization of RSPO fusions in colorectal traditional serrated adenomas.	RSPO3 PTPRK	2.64e-06	2	57	2	28543708
Pubmed	Immunohistochemical localization of exoribonucleases (DIS3L2 and XRN1) in intranuclear inclusion body disease.	DIS3L2 XRN1	2.64e-06	2	57	2	29100804
Pubmed	Investigation of cell signalings and therapeutic targets in PTPRK-RSPO3 fusion-positive colorectal cancer.	RSPO3 PTPRK	2.64e-06	2	57	2	36129915
Pubmed	Organization of focal adhesion plaques is disrupted by action of the HIV-1 protease.	SPTBN5 PLS1 PLS3	3.35e-06	18	57	3	12119179
Pubmed	Molecular cloning and characterization of plastin, a human leukocyte protein expressed in transformed human fibroblasts.	PLS1 PLS3	7.91e-06	3	57	2	3211125
Pubmed	Sequential expression and differential localization of I-, L-, and T-fimbrin during differentiation of the mouse intestine and yolk sac.	PLS1 PLS3	7.91e-06	3	57	2	7655078
Pubmed	The Roles of Actin-Binding Domains 1 and 2 in the Calcium-Dependent Regulation of Actin Filament Bundling by Human Plastins.	PLS1 PLS3	7.91e-06	3	57	2	28694070
Pubmed	Human plastin genes. Comparative gene structure, chromosome location, and differential expression in normal and neoplastic cells.	PLS1 PLS3	7.91e-06	3	57	2	8428952
Pubmed	Frequent PTPRK-RSPO3 fusions and RNF43 mutations in colorectal traditional serrated adenoma.	RSPO3 PTPRK	7.91e-06	3	57	2	26924569
Pubmed	Microglia/macrophage-specific protein Iba1 binds to fimbrin and enhances its actin-bundling activity.	PLS1 PLS3	1.58e-05	4	57	2	14756805
Pubmed	Differential localization of villin and fimbrin during development of the mouse visceral endoderm and intestinal epithelium.	PLS1 PLS3	1.58e-05	4	57	2	2686960
Pubmed	Gata4 blocks somatic cell reprogramming by directly repressing Nanog.	NANOGP8 GATA4	1.58e-05	4	57	2	23132827
Pubmed	Distinct dormancy progression depending on embryonic regions during mouse embryonic diapause†.	NANOGP8 GATA4	2.63e-05	5	57	2	30715198
Pubmed	GATA6 phosphorylation by Erk1/2 propels exit from pluripotency and commitment to primitive endoderm.	NANOGP8 GATA4	3.94e-05	6	57	2	29454706
Pubmed	Exonuclease hDIS3L2 specifies an exosome-independent 3'-5' degradation pathway of human cytoplasmic mRNA.	DIS3L2 XRN1	3.94e-05	6	57	2	23756462
Pubmed	AMPK regulates cell shape of cardiomyocytes by modulating turnover of microtubules through CLIP-170.	ACACA CLIP1	3.94e-05	6	57	2	33251722
Pubmed	Suppression of Erk signalling promotes ground state pluripotency in the mouse embryo.	NANOGP8 GATA4	5.51e-05	7	57	2	19710168
Pubmed	The tuberous sclerosis complex regulates trafficking of glucose transporters and glucose uptake.	TBC1D4 CLIP1	5.51e-05	7	57	2	18511518
Pubmed	Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.	RSPO3 DIS3L2 SPAG17 ANKS1A	6.13e-05	129	57	4	23563607
Pubmed	A Multipronged Unbiased Strategy Guides the Development of an Anti-EGFR/EPHA2-Bispecific Antibody for Combination Cancer Therapy.	IARS2 IGF2R DST ACACA INF2 CCNY	6.54e-05	421	57	6	36976175
Pubmed	The human cytoplasmic dynein interactome reveals novel activators of motility.	IARS2 IGF2R ACACA XRN1 NUBP1 CLIP1 PLS3 ANKS1A	7.24e-05	853	57	8	28718761
Pubmed	Persistent cell migration and adhesion rely on retrograde transport of β(1) integrin.	NANOGP8 GATA4	7.34e-05	8	57	2	26641717
Pubmed	Gata6, Nanog and Erk signaling control cell fate in the inner cell mass through a tristable regulatory network.	NANOGP8 GATA4	7.34e-05	8	57	2	25209243
Pubmed	FGF4 is required for lineage restriction and salt-and-pepper distribution of primitive endoderm factors but not their initial expression in the mouse.	NANOGP8 GATA4	7.34e-05	8	57	2	23193166
Pubmed	Enhancer-promoter interactions can bypass CTCF-mediated boundaries and contribute to phenotypic robustness.	NANOGP8 GATA4	7.34e-05	8	57	2	36717694
Pubmed	Oct4 switches partnering from Sox2 to Sox17 to reinterpret the enhancer code and specify endoderm.	NANOGP8 GATA4	7.34e-05	8	57	2	23474895
Pubmed	Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.	GABRG2 BCL9L ACACA GUCY1B1 SRGAP3 IQSEC2 XRN1 LMTK2 WDR47	9.19e-05	1139	57	9	36417873
Pubmed	Distinct sequential cell behaviours direct primitive endoderm formation in the mouse blastocyst.	NANOGP8 GATA4	9.43e-05	9	57	2	18725515
Pubmed	Bmi1 facilitates primitive endoderm formation by stabilizing Gata6 during early mouse development.	NANOGP8 GATA4	9.43e-05	9	57	2	22713603
Pubmed	A Gata4 nuclear GFP transcriptional reporter to study endoderm and cardiac development in the mouse.	NANOGP8 GATA4	9.43e-05	9	57	2	30530745
Pubmed	Exit from pluripotency is gated by intracellular redistribution of the bHLH transcription factor Tfe3.	NANOGP8 GATA4	9.43e-05	9	57	2	23582324
Pubmed	Mga is essential for the survival of pluripotent cells during peri-implantation development.	NANOGP8 GATA4	9.43e-05	9	57	2	25516968
Pubmed	Nanog is required for primitive endoderm formation through a non-cell autonomous mechanism.	NANOGP8 GATA4	9.43e-05	9	57	2	20435031
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	GABRG2 DST INF2 SRGAP3 IQSEC2 XRN1 DDX3Y SSH2 PLS3 WDR47	9.96e-05	1431	57	10	37142655
Pubmed	A high-throughput approach for measuring temporal changes in the interactome.	NIBAN1 TRMT6 TBC1D4 ACACA CLNS1A NUBP1 CLIP1 PLS1 PLS3 ANKS1A	1.14e-04	1455	57	10	22863883
Pubmed	MyoR modulates cardiac conduction by repressing Gata4.	CACNA2D2 GATA4	1.18e-04	10	57	2	25487574
Pubmed	Lineage Establishment and Progression within the Inner Cell Mass of the Mouse Blastocyst Requires FGFR1 and FGFR2.	NANOGP8 GATA4	1.18e-04	10	57	2	28552559
Pubmed	Sox17 promotes differentiation in mouse embryonic stem cells by directly regulating extraembryonic gene expression and indirectly antagonizing self-renewal.	NANOGP8 GATA4	1.18e-04	10	57	2	20123909
Pubmed	CNOT3-Dependent mRNA Deadenylation Safeguards the Pluripotent State.	NANOGP8 GATA4	1.18e-04	10	57	2	27746116
Pubmed	Ectopic expression of GATA6 bypasses requirement for Grb2 in primitive endoderm formation.	NANOGP8 GATA4	1.18e-04	10	57	2	20925113
Pubmed	PDGF Signaling in Primitive Endoderm Cell Survival Is Mediated by PI3K-mTOR Through p53-Independent Mechanism.	NANOGP8 GATA4	1.44e-04	11	57	2	30913328
Pubmed	Atypical protein kinase C couples cell sorting with primitive endoderm maturation in the mouse blastocyst.	NANOGP8 GATA4	1.44e-04	11	57	2	24067354
Pubmed	The primitive endoderm lineage of the mouse blastocyst: sequential transcription factor activation and regulation of differentiation by Sox17.	NANOGP8 GATA4	1.44e-04	11	57	2	21146513
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	IGF2R DST SRGAP3 IQSEC2 SSH2 CLIP1 ANKS1A WDR47	1.67e-04	963	57	8	28671696
Pubmed	Loss of the Otx2-Binding Site in the Nanog Promoter Affects the Integrity of Embryonic Stem Cell Subtypes and Specification of Inner Cell Mass-Derived Epiblast.	NANOGP8 GATA4	1.72e-04	12	57	2	27292645
Pubmed	Fgfr1 regulates development through the combinatorial use of signaling proteins.	NANOGP8 GATA4	1.72e-04	12	57	2	26341559
Pubmed	RNA Pol II pausing facilitates phased pluripotency transitions by buffering transcription.	NANOGP8 GATA4	1.72e-04	12	57	2	35981753
Pubmed	Klf5 maintains the balance of primitive endoderm versus epiblast specification during mouse embryonic development by suppression of Fgf4.	NANOGP8 GATA4	1.72e-04	12	57	2	28870993
Pubmed	Rescuing the aberrant sex development of H3K9 demethylase Jmjd1a-deficient mice by modulating H3K9 methylation balance.	GATA4 DDX3Y	1.72e-04	12	57	2	28949961
Pubmed	Tsix RNA and the germline factor, PRDM14, link X reactivation and stem cell reprogramming.	NANOGP8 GATA4	1.72e-04	12	57	2	24268575
Pubmed	A transgenic DND1GFP fusion allele reports in vivo expression and RNA-binding targets in undifferentiated mouse germ cells†.	NANOGP8 GATA4	2.03e-04	13	57	2	33394034
Pubmed	Oct4 cell-autonomously promotes primitive endoderm development in the mouse blastocyst.	NANOGP8 GATA4	2.03e-04	13	57	2	23747191
Pubmed	Control of ground-state pluripotency by allelic regulation of Nanog.	NANOGP8 GATA4	2.37e-04	14	57	2	22327294
Pubmed	Distinct Requirements for FGFR1 and FGFR2 in Primitive Endoderm Development and Exit from Pluripotency.	NANOGP8 GATA4	2.37e-04	14	57	2	28552557
Pubmed	Cul3 regulates cytoskeleton protein homeostasis and cell migration during a critical window of brain development.	PLS1 PLS3	2.37e-04	14	57	2	34031387
Pubmed	Heterozygous loss of Zbtb38 leads to early embryonic lethality via the suppression of Nanog and Sox2 expression.	NANOGP8 GATA4	2.37e-04	14	57	2	35297517
Pubmed	A genetic and developmental pathway from STAT3 to the OCT4-NANOG circuit is essential for maintenance of ICM lineages in vivo.	NANOGP8 GATA4	2.37e-04	14	57	2	23788624
Pubmed	GATA6 levels modulate primitive endoderm cell fate choice and timing in the mouse blastocyst.	NANOGP8 GATA4	2.73e-04	15	57	2	24835466
Pubmed	Spatial proteomics reveal that the protein phosphatase PTP1B interacts with and may modify tyrosine phosphorylation of the rhomboid protease RHBDL4.	IGF2R DST INF2 XRN1	2.77e-04	191	57	4	31177093
Pubmed	The REV7 subunit of DNA polymerase ζ is essential for primordial germ cell maintenance in the mouse.	NANOGP8 GATA4	3.12e-04	16	57	2	23463509
Pubmed	Hopx and Hdac2 interact to modulate Gata4 acetylation and embryonic cardiac myocyte proliferation.	GATA4 SIK2	3.12e-04	16	57	2	20833366
Pubmed	Interactomes of Glycogen Synthase Kinase-3 Isoforms.	TBC1D4 DST ACACA ANKS1A	3.90e-04	209	57	4	36779422
Pubmed	Stem cells. m6A mRNA methylation facilitates resolution of naïve pluripotency toward differentiation.	NANOGP8 GATA4	3.97e-04	18	57	2	25569111
Pubmed	The deubiquitinase TRABID stabilizes the K29/K48-specific E3 ubiquitin ligase HECTD1.	TRMT6 DST ACACA XRN1	4.12e-04	212	57	4	33853758
Pubmed	HIPPO pathway members restrict SOX2 to the inner cell mass where it promotes ICM fates in the mouse blastocyst.	NANOGP8 GATA4	4.92e-04	20	57	2	25340657
Pubmed	Establishment of totipotency does not depend on Oct4A.	NANOGP8 GATA4	4.92e-04	20	57	2	23934214
Pubmed	Systematic identification of cancer cell vulnerabilities to natural killer cell-mediated immune surveillance.	ACACA CLIP1 PLS1 PLS3	5.24e-04	226	57	4	31452512
Pubmed	In silico QTL mapping of basal liver iron levels in inbred mouse strains.	IGF2R LMTK2	5.43e-04	21	57	2	21062905
Pubmed	Embryo model completes gastrulation to neurulation and organogenesis.	NANOGP8 GATA4	5.97e-04	22	57	2	36007540
Pubmed	A histone H3 lysine 36 trimethyltransferase links Nkx2-5 to Wolf-Hirschhorn syndrome.	NANOGP8 NSD2	5.97e-04	22	57	2	19483677
Pubmed	USP16-mediated histone H2A lysine-119 deubiquitination during oocyte maturation is a prerequisite for zygotic genome activation.	NANOGP8 KLF18	5.97e-04	22	57	2	35640597
Pubmed	Sin3a is essential for the genome integrity and viability of pluripotent cells.	NANOGP8 GATA4	6.53e-04	23	57	2	22206758
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	HIPK3 TBC1D4 ACACA CACNA2D2 INF2 NSD2 PELI2 CCNY ANKS1A	6.64e-04	1489	57	9	28611215
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	IARS2 IGF2R DST ACACA NSD2 XRN1	6.89e-04	653	57	6	22586326
Pubmed	Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.	TBC1D4 CACNA2D2 IQSEC2	6.95e-04	105	57	3	9628581
Pubmed	Analyzing embryo dormancy at single-cell resolution reveals dynamic transcriptional responses and activation of integrin-Yap/Taz prosurvival signaling.	NANOGP8 GATA4	7.12e-04	24	57	2	39047740
Pubmed	β-Actin mRNA interactome mapping by proximity biotinylation.	DDX3Y PLS3	7.12e-04	24	57	2	31189591
Pubmed	Identification of an FMNL2 Interactome by Quantitative Mass Spectrometry.	IGF2R PLS3 ANKS1A	7.14e-04	106	57	3	38891874
Pubmed	Phosphoproteomic analysis of the developing mouse brain.	CLNS1A SSH2 CLIP1 ANKS1A	7.19e-04	246	57	4	15345747
Pubmed	ZZW-115-dependent inhibition of NUPR1 nuclear translocation sensitizes cancer cells to genotoxic agents.	DST INF2 SSH2 PLS1 PLS3 CCNY	7.29e-04	660	57	6	32780723
Pubmed	Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.	BCL9L TBC1D4 DST CLIP1 ANKS1A	8.21e-04	446	57	5	24255178
Pubmed	Jmjd2c facilitates the assembly of essential enhancer-protein complexes at the onset of embryonic stem cell differentiation.	NANOGP8 GATA4	8.36e-04	26	57	2	28087629
Pubmed	Identification of 15 loci influencing height in a Korean population.	KBTBD8 SPAG17	9.02e-04	27	57	2	19893584
Pubmed	Nodal specifies embryonic visceral endoderm and sustains pluripotent cells in the epiblast before overt axial patterning.	NANOGP8 GATA4	9.71e-04	28	57	2	16728477
Pubmed	Rebalancing gene haploinsufficiency in vivo by targeting chromatin.	NANOGP8 GATA4	9.71e-04	28	57	2	27256596
Pubmed	GATA4-dependent organ-specific endothelial differentiation controls liver development and embryonic hematopoiesis.	RSPO3 GATA4	9.71e-04	28	57	2	28218627
Pubmed	A novel role for the peptidyl-prolyl cis-trans isomerase Cyclophilin A in DNA-repair following replication fork stalling via the MRE11-RAD50-NBS1 complex.	TRMT6 IGF2R DST DDX3Y CLIP1	1.06e-03	472	57	5	38943005
Pubmed	Cdx2 regulates endo-lysosomal function and epithelial cell polarity.	PLS1 PLS3	1.35e-03	33	57	2	20551175
Pubmed	Expression dynamics of Mage family genes during self-renewal and differentiation of mouse pluripotent stem and teratocarcinoma cells.	NANOGP8 GATA4	1.35e-03	33	57	2	31143371
Pubmed	miR-195b is required for proper cellular homeostasis in the elderly.	ACACA GATA4	1.43e-03	34	57	2	38191655
Pubmed	New interaction partners for Nek4.1 and Nek4.2 isoforms: from the DNA damage response to RNA splicing.	DST CLNS1A XRN1 DSG4 SPAG17	1.53e-03	513	57	5	25798074
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	DIS3L2 TBC1D4 DST ACACA INF2 MYO19 XRN1 WDR47	1.56e-03	1353	57	8	29467282
Pubmed	Large-scale analysis of ion channel gene expression in the mouse heart during perinatal development.	KCNC3 CACNA2D2 CLNS1A	1.56e-03	139	57	3	16985003
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	IGF2R TBC1D4 PTPRK NSD2 CLNS1A LMTK2 SSH2	1.58e-03	1049	57	7	27880917
Pubmed	Wnt/Rspondin/β-catenin signals control axonal sorting and lineage progression in Schwann cell development.	FZD9 RSPO3	1.60e-03	36	57	2	24151333
Pubmed	Microarray analysis of Foxa2 mutant mouse embryos reveals novel gene expression and inductive roles for the gastrula organizer and its derivatives.	RSPO3 KBTBD8 PELI2 RNF41	1.61e-03	306	57	4	18973680
Interaction	RNF123 interactions	TRMT6 TBC1D4 DST ACACA INF2 DQX1 SRGAP3 MYO19 CLNS1A IQSEC2 PLS1	7.90e-06	824	53	11	int:RNF123
Cytoband	11q22.3	ZC3H12C ELMOD1	1.39e-03	44	57	2	11q22.3
Cytoband	3q23	XRN1 PLS1	1.39e-03	44	57	2	3q23
Cytoband	7q35	ARHGEF35 ARHGEF5	2.16e-03	55	57	2	7q35
Cytoband	Ensembl 112 genes in cytogenetic band chr3q23	XRN1 PLS1	2.82e-03	63	57	2	chr3q23
Cytoband	Ensembl 112 genes in cytogenetic band chr7q35	ARHGEF35 ARHGEF5	3.09e-03	66	57	2	chr7q35
Cytoband	2q37.1	DIS3L2 SP140	3.18e-03	67	57	2	2q37.1
ToppCell	droplet-Lung-30m-Hematologic-myeloid-intermediate_monocyte-intermediate_monocyte_l33\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	IGF2R MYO19 SIK2 LMTK2	2.79e-05	136	57	4	a43b3db1754c619d328a26a2ba6af4756629a723
ToppCell	primary_visual_cortex-Neuronal-GABAergic_neuron-Pvalb-Pvalb_Reln_Itm2a\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	NIBAN1 TBC1D4 KCNC3 CACNA2D2	3.48e-05	144	57	4	0bbe670454846cf9bc7464ae4e91488415c4111d
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22-Lymphocytic-Lymphocytic_T-CD8-positive,_mature_gamma-delta_T_cell\|Severe-critical_progression_d12-22 / Compartment, severity and other cell annotations on 10x 3' data (130k)	XYLT1 ARHGEF35 PTPRK PLS3	4.19e-05	151	57	4	9ebfbdccc9656fce8990d06622f225009633f07c
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22-Lymphocytic-Lymphocytic_T-CD8-positive,_mature_gamma-delta_T_cell-T_gdT_c14-TRDV2\|Severe-critical_progression_d12-22 / Compartment, severity and other cell annotations on 10x 3' data (130k)	XYLT1 ARHGEF35 PTPRK PLS3	4.19e-05	151	57	4	29d91a7d1470121af45fb8bb35175f2acced4551
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-4M-Stem_cells-stem_cells_1\|Organoid-4M / Sample Type, Dataset, Time_group, and Cell type.	XYLT1 FZD9 NIBAN1 MYO19	4.30e-05	152	57	4	375c9ef88c7703a002e868645a722c35e046ef1e
ToppCell	frontal_cortex-Neuronal-GABAergic_neuron-Pvalb-Pvalb_Tpbg\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	NIBAN1 TBC1D4 KCNC3 CACNA2D2	5.78e-05	164	57	4	f0499e6c1b17c4df72b18b294e3b53ef723da2ac
ToppCell	PND10-Immune-Immune_Myeloid-DC-maDC-maDC_mature\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	TBC1D4 CACNA2D2 ZC3H12C SP140	6.50e-05	169	57	4	a83e4078db91ecedee637b28b12ec38640fe45f9
ToppCell	PND10-Immune-Immune_Myeloid-DC-maDC\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	TBC1D4 CACNA2D2 ZC3H12C SP140	6.50e-05	169	57	4	f914aa8899fa170a09da31e5fad86de897ea789b
ToppCell	saliva-Severe-critical_progression_d12-22_no-steroids-Myeloid-Granulocytic-Neutrophil-Neu_c5-GSTP1(high)OASL(low)\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	TXLNB XRN1 PLS1 ANKS1A	6.65e-05	170	57	4	07b561cd9c528bc8444c9385e1de621eee7b697e
ToppCell	droplet-Spleen-nan-3m-Myeloid-granulocyte\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DQX1 ARHGEF5 PELI2 ANKS1A	6.65e-05	170	57	4	dbd6c9c7be824a1ff1b31af791064127cafbd194
ToppCell	droplet-Lung-nan-21m-Myeloid-dendritic_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TBC1D4 TXLNB SRGAP3 ZC3H12C	6.80e-05	171	57	4	159ce6d5513008532dd7785b915b3fe7440cc4b2
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW19-Neuronal-Neuron\|GW19 / Sample Type, Dataset, Time_group, and Cell type.	ACP6 PELI2 SSH2 PLS1	7.44e-05	175	57	4	2812ac2ef41d245db544697fb6da1883361c96e8
ToppCell	droplet-Heart-nan-3m\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TBC1D4 TXLNB XRN1 GATA4	7.60e-05	176	57	4	749b47eac5436fa34e0d243ffbc6f1897f4e431e
ToppCell	tumor_Lymph_Node_/_Brain-Fibroblasts-Smooth_muscle_cells\|Fibroblasts / Location, Cell class and cell subclass	NIBAN1 DIS3L2 SRGAP3 WDR47	8.12e-05	179	57	4	83506e00fe99b6450efd2f13f716926a0a4b03cd
ToppCell	facs-Brain_Non-Myeloid-Cerebellum\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GABRG2 TBC1D4 KCNC3 ELMOD1	9.22e-05	185	57	4	c083a4974590b9ed3ecafedd3e9cdebc5047fe39
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-3m\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GABRG2 TBC1D4 GUCY1B1 ELMOD1	9.22e-05	185	57	4	cdd75abdaa1ecedfd2e636203b83a6ac1782f0c3
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-24m-Neuronal-neuron\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GABRG2 KCNC3 CACNA2D2 ELMOD1	9.81e-05	188	57	4	1efbc99bcd6542e5d9fa91edb7c4295167914786
ToppCell	droplet-Lung-LUNG-1m-Mesenchymal-bronchial_smooth_muscle_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FZD9 RSPO3 GUCY1B1 ARHGEF5	1.00e-04	189	57	4	4dc32b463546bbe7250dddd281b92ad17ec22da1
ToppCell	droplet-Lung-LUNG-1m-Mesenchymal-Airway_Smooth_Muscle\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FZD9 RSPO3 GUCY1B1 ARHGEF5	1.00e-04	189	57	4	0d06bf0d7191d13a1c4f30a7881e7ea1093bfd6f
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-4M-Neuronal-ventral_progenitors_and_neurons_1\|Organoid-4M / Sample Type, Dataset, Time_group, and Cell type.	GABRG2 CACNA2D2 GUCY1B1 ELMOD1	1.02e-04	190	57	4	6e92c78799f34b31d098854503c796edb0dc7f80
ToppCell	CTRL-Myeloid-Alveolar_Macrophage\|Myeloid / Disease state, Lineage and Cell class	TBC1D4 DST SIK2 ANKS1A	1.09e-04	193	57	4	80871d963c23a6befe58e5e60b7f7d1a1b227ce2
ToppCell	3'-GW_trimst-2-SmallIntestine-Mesenchymal-fibroblastic-Stromal_3_(KCNN3+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TXLNB PTPRK RTL3 GUCY1B1	1.09e-04	193	57	4	96c85b250d04b5f400512097d925061c6dc2906b
ToppCell	Neuron-Postmitotic-Inhibitory_Neuron-MGE2\|World / Primary Cells by Cluster	GABRG2 CACNA2D2 PLS3 ANKS1A	1.11e-04	194	57	4	b42fd64b0fb95434a9e4e6586f31d26114a4074b
ToppCell	Neuron-Postmitotic-Inhibitory_Neuron-MGE2-10\|World / Primary Cells by Cluster	GABRG2 CACNA2D2 PLS3 ANKS1A	1.11e-04	194	57	4	81e7bc6516ab8d02ccd1c76a56a3533b788c27c8
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	ACACA PTPRK CACNA2D2 LMTK2	1.11e-04	194	57	4	97534c8bba895a7913665e03ae4e5c4a6ad71daf
ToppCell	10x_3'_v3-lymph_node_(10x_3'_v3)-lymphocytic-innate_lymphocytic-innate_lymphoid_cell\|lymph_node_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	NIBAN1 DST SRGAP3 LNX1	1.13e-04	195	57	4	d70b49f6b9c6c4422adb2936c837a1af7569fb0a
ToppCell	COVID-19-Heart-CM_2\|Heart / Disease (COVID-19 only), tissue and cell type	NIBAN1 TBC1D4 DST GATA4	1.13e-04	195	57	4	75fc81bddb246dca3b437fb60827b1d4fe416405
ToppCell	droplet-Limb_Muscle-MUSCLE-30m-Mesenchymal\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NIBAN1 XRN1 DDX3Y CLIP1	1.13e-04	195	57	4	5c86fddd6d0530beecf45ea5ba6b823123847696
ToppCell	facs-Skin-Telogen-3m-Epithelial-bulge_keratinocyte\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DST PTPRK PELI2 PLS3	1.15e-04	196	57	4	90edf61116ffcb4f8b6be3d0a05732d59b0a87d5
ToppCell	ASK440-Epithelial-Type_1\|Epithelial / Donor, Lineage and Cell class of Lung cells from Dropseq	DST INF2 PLS3 ANKS1A	1.17e-04	197	57	4	782449c522c9e16e72bf999a73090688a3aefe06
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c12-FOXP3\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	NIBAN1 TBC1D4 CLNS1A SP140	1.17e-04	197	57	4	7c9df6025b9d168bd6d041c6cff1e87e08b11847
ToppCell	Parenchymal-NucSeq-Epithelial-Epi_alveolar-AT2\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	TBC1D4 ACACA PTPRK CACNA2D2	1.20e-04	198	57	4	2e2a4e1756bba6f4fbe529559a97d2993c890b4b
ToppCell	Bronchus_Control_(B.)-Endothelial-TX\|Bronchus_Control_(B.) / Sample group, Lineage and Cell type	SPTBN5 FZD9 RSPO3 DST	1.20e-04	198	57	4	feac39036b5c0ab97b524cc366286942d136d42f
ToppCell	Bronchial-NucSeq-Epithelial-Epi_alveolar-AT2\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	TBC1D4 ACACA PTPRK CACNA2D2	1.20e-04	198	57	4	f948391296c261c473d339069a6d0f20ccd6f38f
ToppCell	Bronchus_Control_(B.)-Endothelial-TX-Bronchial_vessel\|Bronchus_Control_(B.) / Sample group, Lineage and Cell type	FZD9 RSPO3 DST PLS3	1.20e-04	198	57	4	dcf334d13e5b0018fee24febccfef91c9e17843b
ToppCell	control-cDC\|control / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	NIBAN1 DST KCNC3 SRGAP3	1.24e-04	200	57	4	4a6d17a4225be38537d3dd8a39512051f597f4e0
ToppCell	severe-cDC\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	TRMT6 DST KCNC3 SRGAP3	1.24e-04	200	57	4	23e3d2fb86a71f62cca32640842fbba5dd163453
ToppCell	Tracheal-NucSeq-Epithelial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	ACACA PTPRK SRGAP3 LNX1	1.24e-04	200	57	4	d3af0a706baf66e3f32e67b17dcfc31e5b32ce0e
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-2m-Neuronal-Intermediate\|2m / Sample Type, Dataset, Time_group, and Cell type.	DST SRGAP3 DDX3Y ANKS1A	1.24e-04	200	57	4	2a635694844ddabcd98462c5636a6f41a3f08a46
ToppCell	LPS_IL1RA-Endothelial-Endothelial-Activated_Alv_Cap\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	DST GUCY1B1 ZC3H12C CCNY	1.24e-04	200	57	4	79e51afb57ca38aacebd0298e5e727b55c0cfff9
Drug	dipyrromethene	ACACA SPAG17 CLIP1	8.86e-06	17	55	3	CID003083424
Drug	fipronil	GABRG2 NIBAN1 CLNS1A ANKS1A	1.44e-05	61	55	4	CID000003352
Drug	4,4'-dipyridylamine	DST SPAG17	1.72e-05	3	55	2	CID000225529
Disease	systolic blood pressure, alcohol drinking	RSPO3 GUCY1B1 GATA4 LNX1	1.04e-04	128	56	4	EFO_0004329, EFO_0006335
Disease	macrophage inflammatory protein 1b measurement	GABRG2 ACACA CACNA2D2 MYO19	1.32e-04	136	56	4	EFO_0008219
Disease	nephroblastoma (is_implicated_in)	DIS3L2 IGF2R	3.17e-04	14	56	2	DOID:2154 (is_implicated_in)
Disease	pulse pressure measurement, alcohol drinking	GATA4 LNX1 ELMOD1	3.24e-04	70	56	3	EFO_0004329, EFO_0005763
Disease	peak expiratory flow	DST PTPRK INF2 XRN1 SSH2 ANKS1A	3.56e-04	498	56	6	EFO_0009718
Disease	Congenital hernia of foramen of Morgagni	IGF2R GATA4	5.93e-04	19	56	2	C0265699
Disease	Congenital hernia of foramen of Bochdalek	IGF2R GATA4	5.93e-04	19	56	2	C0265700
Disease	Congenital diaphragmatic hernia	IGF2R GATA4	7.26e-04	21	56	2	C0235833
Disease	renal system measurement, blood urea nitrogen measurement	RSPO3 KBTBD8	7.98e-04	22	56	2	EFO_0004741, EFO_0004742
Disease	pulse pressure measurement, alcohol consumption measurement	GATA4 LNX1	7.98e-04	22	56	2	EFO_0005763, EFO_0007878
Disease	triglyceride measurement, very low density lipoprotein cholesterol measurement	FZD9 RSPO3 IGF2R GATA4	8.72e-04	224	56	4	EFO_0004530, EFO_0008317
Disease	Epilepsy	GABRG2 CACNA2D2 IQSEC2	1.18e-03	109	56	3	C0014544
Disease	Beta blocking agent use measurement	RSPO3 GUCY1B1 SIK2	1.34e-03	114	56	3	EFO_0009929
Disease	diastolic blood pressure, alcohol drinking	RSPO3 GUCY1B1 GATA4	1.48e-03	118	56	3	EFO_0004329, EFO_0006336
Disease	smoking behavior, BMI-adjusted waist circumference	RSPO3 DIS3L2 ANKS1A	1.63e-03	122	56	3	EFO_0004318, EFO_0007789
Disease	Huntington's disease (implicated_via_orthology)	PLS1 PLS3	1.69e-03	32	56	2	DOID:12858 (implicated_via_orthology)
Disease	triglyceride measurement, high density lipoprotein cholesterol measurement	FZD9 RSPO3 IGF2R GATA4	1.83e-03	274	56	4	EFO_0004530, EFO_0004612
Disease	chronic obstructive pulmonary disease	FZD9 RSPO3 SRGAP3 PELI2 SSH2 LNX1	1.90e-03	688	56	6	EFO_0000341

Protein segments in the cluster

Peptide	Gene	Start	Entry
NPDMALCPHFAASEG	ELMOD1	316	Q8N336
DQPQKCGPNSHCEMD	CACNA2D2	866	Q9NY47
ACPIQSEHLDMAPFS	ARHGEF5	126	Q12774
MDAQDCQAAASPEPP	ABHD12B	1	Q7Z5M8
ACPIQSEHLDMAPFS	ARHGEF35	126	A5YM69
HPCTEMVADVNLPAA	ACACA	446	Q13085
ALEPPDMDQDAQSHA	ANKS1A	1101	Q92625
DDLNMEFNPSDHPRA	CCNY	51	Q8ND76
DMAPDTLQKQADHCN	DIS3L2	726	Q8IYB7
MEEVPHDCPGADSAQ	NUBP1	1	P53384
FAASEDEAQPCQPMD	MYO19	311	Q96H55
HMNPQEVEEPSACAD	DST	3156	Q03001
DEALNCHPSGPMSEE	IQSEC2	476	Q5JU85
AHPEDRDVSNICAPM	DSG4	686	Q86SJ6
DCKHLIPMNPNDDSL	PLS1	141	Q14651
PDCRHVIPMNPNTDD	PLS3	141	P13797
AAFHPDCLNIEMPDG	NSD2	851	O96028
CSSPAALDSNHNMAP	LNX1	601	Q8TBB1
SEPLCLSDNLMHQDN	LMTK2	696	Q8IWU2
CLMSPENSDPQFHLE	GUCY1B1	571	Q02153
NADEHMANTDSICQP	HIPK3	1006	Q9H422
GECHFLDQPAPEALM	DQX1	426	Q8TE96
QQPAAAAACEPVDHA	INF2	386	Q27J81
DPASDAMDPFHACSI	KBTBD8	21	Q8NFY9
NDPHALCMEAPENAT	FZD9	146	O00144
ANPAARHPNLDMFDD	GATA4	196	P43694
FTAMCECQALHPDPE	CLNS1A	126	P54105
QLQLHNFPMDEHSCP	GABRG2	191	P18507
THNCNVADPAMAAPQ	BCL9L	176	Q86UU0
DAPEPQNCMPLTAHA	KLF18	31	A0A0U1RQI7
SNCPPHIENFSDIDM	DDX3Y	171	O15523
LDNLMSHLSDCEHNP	RNF41	96	Q9H4P4
EDCPTQAQMSEDPPH	CLIP1	1391	P30622
DCLDMDPKAPQHVVN	PTPRK	441	Q15262
PTATACPMKSNEHDD	IGF2R	1501	P11717
PMQAAINCPHISEAE	RTL3	421	Q8N8U3
CMHFQPNSPASDLEA	NANOGP8	251	Q6NSW7
MFSPGQEEHCAPNKE	PELI2	1	Q9HAT8
LFDCEMLDAVDPQHN	SIK2	906	Q9H0K1
SQHNLPMDCLVDEDG	IARS2	406	Q9NSE4
VACDDMQPKHIQAQP	REELD1	31	A0A1B0GV85
LDAQSQPMAALDCPD	SPTBN5	1161	Q9NRC6
PSDPSQCDANNMKHS	SPAG17	691	Q6Q759
CVNNAMSAEDEPQHL	WDR47	96	O94967
LENSPHCDTMVDNNL	XYLT1	536	Q86Y38
EPSQAAAIHPDNCEE	NIBAN1	751	Q9BZQ8
PENKPGHMEQDEDSC	SSH2	796	Q76I76
PHMGDEVCQVSAQQP	SRGAP3	336	O43295
MNGIIHQCSHPNDDD	XRN1	36	Q8IZH2
LDNCPEGLEANNHTM	RSPO3	126	Q9BXY4
VAAEQAHNLPSCPML	ACP6	256	Q9NPH0
QPDDPESQMACHVFR	TBC1D4	146	O60343
ENEDSMAEAPESNHP	TRMT6	301	Q9UJA5
SNACHEMDDIAVPQE	SP140	166	Q13342
PAPACAAEEHVAAMV	TXLNB	631	Q8N3L3
SPDPQLEENLKCQHM	ZC3H12C	651	Q9C0D7
LHHAFQMDSCLPQPN	UHRF1BP1	666	Q6BDS2
ALAHEDCPAIDQPAM	KCNC3	671	Q14003