Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	structural constituent of postsynaptic actin cytoskeleton	POTEF POTEE POTEI POTEJ	2.50e-07	11	107	4	GO:0098973
GeneOntologyMolecularFunction	1-phosphatidylinositol-3-kinase activity	PIK3C2B PIK3CA ATM	2.39e-05	11	107	3	GO:0016303
GeneOntologyMolecularFunction	structural constituent of postsynapse	POTEF POTEE POTEI POTEJ	2.50e-05	32	107	4	GO:0099186
GeneOntologyMolecularFunction	structural constituent of synapse	POTEF POTEE POTEI POTEJ	7.46e-05	42	107	4	GO:0098918
GeneOntologyMolecularFunction	ryanodine-sensitive calcium-release channel activity	RYR1 RYR3	1.69e-04	4	107	2	GO:0005219
GeneOntologyMolecularFunction	kinase binding	PRPSAP1 KIF13B PDE8A NBEAL1 POTEF TOM1L1 PYDC1 IQGAP1 POTEE PTPN14 RHOBTB2 RACGAP1 POTEI POTEJ IKBKB	2.02e-04	969	107	15	GO:0019900
GeneOntologyMolecularFunction	3',5'-cyclic-AMP phosphodiesterase activity	PDE4D PDE8A PDE8B	2.14e-04	22	107	3	GO:0004115
GeneOntologyMolecularFunction	3',5'-cyclic-GMP phosphodiesterase activity	PDE4D PDE8A PDE8B	2.79e-04	24	107	3	GO:0047555
GeneOntologyMolecularFunction	3',5'-cyclic-nucleotide phosphodiesterase activity	PDE4D PDE8A PDE8B	3.16e-04	25	107	3	GO:0004114
GeneOntologyMolecularFunction	phosphatidylinositol kinase activity	PIK3C2B PIK3CA ATM	3.56e-04	26	107	3	GO:0052742
GeneOntologyMolecularFunction	cyclic-nucleotide phosphodiesterase activity	PDE4D PDE8A PDE8B	3.98e-04	27	107	3	GO:0004112
GeneOntologyMolecularFunction	calcium-induced calcium release activity	RYR1 RYR3	4.21e-04	6	107	2	GO:0048763
GeneOntologyMolecularFunction	1-phosphatidylinositol-4-phosphate 3-kinase activity	PIK3C2B PIK3CA	5.87e-04	7	107	2	GO:0035005
GeneOntologyMolecularFunction	intracellularly ligand-gated monoatomic ion channel activity	HCN4 RYR1 RYR3	7.26e-04	33	107	3	GO:0005217
GeneOntologyMolecularFunction	protein kinase binding	KIF13B NBEAL1 POTEF TOM1L1 PYDC1 IQGAP1 POTEE PTPN14 RHOBTB2 RACGAP1 POTEI POTEJ IKBKB	7.92e-04	873	107	13	GO:0019901
GeneOntologyMolecularFunction	lipid kinase activity	PIK3C2B PIK3CA ATM	1.38e-03	41	107	3	GO:0001727
GeneOntologyMolecularFunction	enzyme regulator activity	DOCK3 PRPSAP1 ABCA2 PDE8A ANXA4 TOM1L1 PLCD4 PYDC1 PABIR3 PPP4R4 IQGAP1 RUNDC3A NF1 PIK3CA RACGAP1 CCAR2 ACAP2	1.40e-03	1418	107	17	GO:0030234
GeneOntologyMolecularFunction	small GTPase binding	DOCK3 IQGAP1 XPO5 EHD1 DIAPH3 ACAP2 RABGGTA	1.72e-03	321	107	7	GO:0031267
GeneOntologyMolecularFunction	phosphoric diester hydrolase activity	PDE4D PDE8A PLCD4 PDE8B	1.84e-03	97	107	4	GO:0008081
GeneOntologyBiologicalProcess	cAMP metabolic process	PDE4D PDE8A ADCY3 PDE8B	7.67e-06	25	106	4	GO:0046058
GeneOntologyBiologicalProcess	cAMP catabolic process	PDE4D PDE8A PDE8B	1.08e-05	9	106	3	GO:0006198
GeneOntologyBiologicalProcess	postsynaptic actin cytoskeleton organization	POTEF POTEE POTEI POTEJ	1.86e-05	31	106	4	GO:0098974
GeneOntologyBiologicalProcess	postsynaptic cytoskeleton organization	POTEF POTEE POTEI POTEJ	3.05e-05	35	106	4	GO:0099188
GeneOntologyBiologicalProcess	cyclic nucleotide catabolic process	PDE4D PDE8A PDE8B	4.61e-05	14	106	3	GO:0009214
GeneOntologyBiologicalProcess	actin filament-based process	PDE4D HCN4 POTEF IQGAP1 POTEE NF1 PIK3CA RHOBTB2 CTNNA3 RACGAP1 DIAPH3 POTEI POTEJ IKBKB ACAP2	6.49e-05	912	106	15	GO:0030029
GeneOntologyBiologicalProcess	cyclic purine nucleotide metabolic process	PDE4D PDE8A ADCY3 PDE8B	7.64e-05	44	106	4	GO:0052652
GeneOntologyBiologicalProcess	cyclic nucleotide metabolic process	PDE4D PDE8A ADCY3 PDE8B	8.35e-05	45	106	4	GO:0009187
GeneOntologyBiologicalProcess	phosphatidylinositol-3-phosphate biosynthetic process	PIK3C2B PIK3CA ATM	1.89e-04	22	106	3	GO:0036092
GeneOntologyCellularComponent	NuA4 histone acetyltransferase complex	POTEF TRRAP POTEE YEATS2 POTEI POTEJ	1.27e-08	32	107	6	GO:0035267
GeneOntologyCellularComponent	H4/H2A histone acetyltransferase complex	POTEF TRRAP POTEE YEATS2 POTEI POTEJ	1.27e-08	32	107	6	GO:0043189
GeneOntologyCellularComponent	H4 histone acetyltransferase complex	POTEF TRRAP POTEE YEATS2 POTEI POTEJ	1.08e-07	45	107	6	GO:1902562
GeneOntologyCellularComponent	histone acetyltransferase complex	POTEF TRRAP POTEE YEATS2 POTEI POTEJ	8.82e-06	94	107	6	GO:0000123
GeneOntologyCellularComponent	protein acetyltransferase complex	POTEF TRRAP POTEE YEATS2 POTEI POTEJ	1.58e-05	104	107	6	GO:0031248
GeneOntologyCellularComponent	acetyltransferase complex	POTEF TRRAP POTEE YEATS2 POTEI POTEJ	2.06e-05	109	107	6	GO:1902493
GeneOntologyCellularComponent	actin filament	POTEF IQGAP1 POTEE DIAPH3 POTEI POTEJ	1.06e-04	146	107	6	GO:0005884
GeneOntologyCellularComponent	membrane protein complex	GPR89B STX8 ABCA2 PDE4D OSTM1 COPB1 HCN4 PIGS GOSR1 CDH23 RYR1 RHD RYR3 PIK3C2B PIK3CA SCNN1A GPR89A DIAPH3 IKBKB	1.99e-04	1498	107	19	GO:0098796
GeneOntologyCellularComponent	Golgi stack	GPR89B GOSR1 TOM1L1 ST6GAL1 GPR89A CHSY3	2.51e-04	171	107	6	GO:0005795
GeneOntologyCellularComponent	supramolecular fiber	KIF21B KIF13B CYP2A6 PDE4D POTEF KIF21A TEKT5 RYR1 RYR3 IQGAP1 POTEE RACGAP1 AK1 DIAPH3 POTEI POTEJ	3.21e-04	1179	107	16	GO:0099512
GeneOntologyCellularComponent	supramolecular polymer	KIF21B KIF13B CYP2A6 PDE4D POTEF KIF21A TEKT5 RYR1 RYR3 IQGAP1 POTEE RACGAP1 AK1 DIAPH3 POTEI POTEJ	3.46e-04	1187	107	16	GO:0099081
GeneOntologyCellularComponent	transferase complex	PRPSAP1 POLD1 POTEF PYDC1 PCMTD1 TRRAP POTEE YEATS2 PIK3C2B PIK3CA POTEI POTEJ IKBKB RABGGTA	3.97e-04	963	107	14	GO:1990234
GeneOntologyCellularComponent	Golgi apparatus subcompartment	GPR89B STX8 RELCH GOSR1 TOM1L1 ST6GAL1 GPR89A CHSY3 DOP1B	4.56e-04	443	107	9	GO:0098791
GeneOntologyCellularComponent	Golgi cisterna	GPR89B GOSR1 ST6GAL1 GPR89A CHSY3	6.54e-04	135	107	5	GO:0031985
GeneOntologyCellularComponent	polymeric cytoskeletal fiber	KIF21B KIF13B CYP2A6 POTEF KIF21A TEKT5 IQGAP1 POTEE RACGAP1 AK1 DIAPH3 POTEI POTEJ	6.81e-04	899	107	13	GO:0099513
GeneOntologyCellularComponent	IkappaB kinase complex	PYDC1 IKBKB	7.12e-04	8	107	2	GO:0008385
GeneOntologyCellularComponent	monoatomic ion channel complex	GPR89B PDE4D OSTM1 HCN4 RYR1 RYR3 SCNN1A GPR89A	7.30e-04	378	107	8	GO:0034702
GeneOntologyCellularComponent	junctional membrane complex	RYR1 RYR3	9.13e-04	9	107	2	GO:0030314
GeneOntologyCellularComponent	perinuclear region of cytoplasm	STX8 PDE4D PDE8A HCN4 ANXA4 RYR1 RYR3 PTPRM PIK3CA PDE8B MRFAP1 EHD1 AK1	9.68e-04	934	107	13	GO:0048471
GeneOntologyCellularComponent	cytoplasmic vesicle membrane	GPR89B STX8 ABCA2 COPB1 ANXA4 TOM1L1 TLR8 SNX13 IQGAP1 RHOBTB2 EHD1 GPR89A ATM DIAPH3 ACAP2 DOP1B	9.81e-04	1307	107	16	GO:0030659
GeneOntologyCellularComponent	endosome membrane	STX8 ABCA2 TOM1L1 TLR8 SNX13 RHOBTB2 EHD1 DIAPH3 ACAP2 DOP1B	1.05e-03	602	107	10	GO:0010008
GeneOntologyCellularComponent	vesicle membrane	GPR89B STX8 ABCA2 COPB1 ANXA4 TOM1L1 TLR8 SNX13 IQGAP1 RHOBTB2 EHD1 GPR89A ATM DIAPH3 ACAP2 DOP1B	1.13e-03	1325	107	16	GO:0012506
GeneOntologyCellularComponent	Golgi cisterna membrane	GPR89B ST6GAL1 GPR89A CHSY3	1.39e-03	94	107	4	GO:0032580
GeneOntologyCellularComponent	transmembrane transporter complex	GPR89B ABCA2 PDE4D OSTM1 HCN4 RYR1 RYR3 SCNN1A GPR89A	1.47e-03	523	107	9	GO:1902495
GeneOntologyCellularComponent	transferase complex, transferring phosphorus-containing groups	PRPSAP1 POLD1 PYDC1 TRRAP PIK3C2B PIK3CA IKBKB	1.69e-03	335	107	7	GO:0061695
GeneOntologyCellularComponent	kinesin complex	KIF21B KIF13B KIF21A	2.02e-03	49	107	3	GO:0005871
GeneOntologyCellularComponent	transporter complex	GPR89B ABCA2 PDE4D OSTM1 HCN4 RYR1 RYR3 SCNN1A GPR89A	2.07e-03	550	107	9	GO:1990351
GeneOntologyCellularComponent	cytoplasmic side of plasma membrane	RYR1 RYR3 IQGAP1 RACGAP1 IKBKB	2.64e-03	185	107	5	GO:0009898
GeneOntologyCellularComponent	Golgi-associated vesicle membrane	GPR89B COPB1 GPR89A	3.78e-03	61	107	3	GO:0030660
Domain	ARM-type_fold	DOCK3 RELCH COPB1 NBEAL1 TRRAP PPP4R4 SIL1 RYR3 NF1 XPO5 PIK3C2B CEBPZ PIK3CA MROH2B NUP188 ATM DIAPH3 TANGO6	5.59e-13	339	105	18	IPR016024
Domain	-	TRRAP PIK3C2B PIK3CA ATM	1.63e-06	16	105	4	1.10.1070.11
Domain	Actin_CS	POTEF POTEE POTEI POTEJ	1.63e-06	16	105	4	IPR004001
Domain	PI3Kc	TRRAP PIK3C2B PIK3CA ATM	1.63e-06	16	105	4	SM00146
Domain	ACTINS_2	POTEF POTEE POTEI POTEJ	2.12e-06	17	105	4	PS00432
Domain	PI3/4_kinase_cat_dom	TRRAP PIK3C2B PIK3CA ATM	2.72e-06	18	105	4	IPR000403
Domain	PI3_PI4_kinase	TRRAP PIK3C2B PIK3CA ATM	2.72e-06	18	105	4	PF00454
Domain	PI3_4_KINASE_3	TRRAP PIK3C2B PIK3CA ATM	2.72e-06	18	105	4	PS50290
Domain	PI3_4_KINASE_1	TRRAP PIK3C2B PIK3CA ATM	2.72e-06	18	105	4	PS00915
Domain	PI3_4_KINASE_2	TRRAP PIK3C2B PIK3CA ATM	2.72e-06	18	105	4	PS00916
Domain	Actin/actin-like_CS	POTEF POTEE POTEI POTEJ	2.72e-06	18	105	4	IPR020902
Domain	ACTINS_ACT_LIKE	POTEF POTEE POTEI POTEJ	3.43e-06	19	105	4	PS01132
Domain	-	RELCH COPB1 TRRAP PPP4R4 SIL1 NF1 XPO5 MROH2B TANGO6	4.50e-06	222	105	9	1.25.10.10
Domain	ARM-like	RELCH COPB1 TRRAP PPP4R4 SIL1 NF1 XPO5 MROH2B TANGO6	2.16e-05	270	105	9	IPR011989
Domain	Actin	POTEF POTEE POTEI POTEJ	2.64e-05	31	105	4	IPR004000
Domain	Actin	POTEF POTEE POTEI POTEJ	2.64e-05	31	105	4	PF00022
Domain	ACTIN	POTEF POTEE POTEI POTEJ	2.64e-05	31	105	4	SM00268
Domain	Ank_2	POTEB3 POTEF ANKRD26 LRRK1 POTEE POTEI POTEJ ACAP2	2.90e-05	215	105	8	PF12796
Domain	PDEase_PDE8	PDE8A PDE8B	3.13e-05	2	105	2	IPR013938
Domain	PI3/4_kinase_CS	PIK3C2B PIK3CA ATM	7.48e-05	15	105	3	IPR018936
Domain	P-loop_NTPase	KIF21B EEFSEC KIF13B ABCA2 KIF21A CHD1 CHD2 IQCN LRRK1 TEP1 IQGAP1 DDX10 RHOBTB2 EHD1 AK1	7.77e-05	848	105	15	IPR027417
Domain	-	POTEB3 POTEF ANKRD26 LRRK1 POTEE POTEI POTEJ ACAP2	7.94e-05	248	105	8	1.25.40.20
Domain	ANK	POTEB3 POTEF ANKRD26 LRRK1 POTEE POTEI POTEJ ACAP2	8.64e-05	251	105	8	SM00248
Domain	ANK_REPEAT	POTEB3 POTEF ANKRD26 LRRK1 POTEE POTEI POTEJ ACAP2	9.13e-05	253	105	8	PS50088
Domain	DUF4208	CHD1 CHD2	9.36e-05	3	105	2	PF13907
Domain	Ryanrecept_TM4-6	RYR1 RYR3	9.36e-05	3	105	2	IPR009460
Domain	RyR	RYR1 RYR3	9.36e-05	3	105	2	PF02026
Domain	Ryanodine_rcpt	RYR1 RYR3	9.36e-05	3	105	2	IPR003032
Domain	DUF4208	CHD1 CHD2	9.36e-05	3	105	2	SM01176
Domain	DUF4208	CHD1 CHD2	9.36e-05	3	105	2	IPR025260
Domain	RR_TM4-6	RYR1 RYR3	9.36e-05	3	105	2	PF06459
Domain	Ryan_recept	RYR1 RYR3	9.36e-05	3	105	2	IPR013333
Domain	Ankyrin_rpt-contain_dom	POTEB3 POTEF ANKRD26 LRRK1 POTEE POTEI POTEJ ACAP2	9.38e-05	254	105	8	IPR020683
Domain	ANK_REP_REGION	POTEB3 POTEF ANKRD26 LRRK1 POTEE POTEI POTEJ ACAP2	9.38e-05	254	105	8	PS50297
Domain	Ankyrin_rpt	POTEB3 POTEF ANKRD26 LRRK1 POTEE POTEI POTEJ ACAP2	1.16e-04	262	105	8	IPR002110
Domain	PDEase	PDE4D PDE8A PDE8B	1.57e-04	19	105	3	IPR023088
Domain	PDEase_I	PDE4D PDE8A PDE8B	2.13e-04	21	105	3	PF00233
Domain	PDEASE_I	PDE4D PDE8A PDE8B	2.13e-04	21	105	3	PS00126
Domain	PDEase_CS	PDE4D PDE8A PDE8B	2.13e-04	21	105	3	IPR023174
Domain	-	PDE4D PDE8A PDE8B	2.46e-04	22	105	3	1.10.1300.10
Domain	PDEase_catalytic_dom	PDE4D PDE8A PDE8B	2.82e-04	23	105	3	IPR002073
Domain	Ank	POTEF ANKRD26 LRRK1 POTEE POTEI POTEJ ACAP2	3.04e-04	228	105	7	PF00023
Domain	HDc	PDE4D PDE8A PDE8B	3.21e-04	24	105	3	SM00471
Domain	HD/PDEase_dom	PDE4D PDE8A PDE8B	3.21e-04	24	105	3	IPR003607
Domain	RIH_assoc	RYR1 RYR3	4.63e-04	6	105	2	PF08454
Domain	RIH_assoc-dom	RYR1 RYR3	4.63e-04	6	105	2	IPR013662
Domain	RIH_dom	RYR1 RYR3	4.63e-04	6	105	2	IPR000699
Domain	Ins145_P3_rcpt	RYR1 RYR3	4.63e-04	6	105	2	IPR014821
Domain	Ryanodine_recept-rel	RYR1 RYR3	4.63e-04	6	105	2	IPR015925
Domain	FAT	TRRAP ATM	4.63e-04	6	105	2	PS51189
Domain	FATC	TRRAP ATM	4.63e-04	6	105	2	PS51190
Domain	-	RYR1 RYR3	4.63e-04	6	105	2	1.25.10.30
Domain	FAT	TRRAP ATM	4.63e-04	6	105	2	PF02259
Domain	PIK-rel_kinase_FAT	TRRAP ATM	4.63e-04	6	105	2	IPR003151
Domain	FATC_dom	TRRAP ATM	4.63e-04	6	105	2	IPR003152
Domain	RYDR_ITPR	RYR1 RYR3	4.63e-04	6	105	2	PF01365
Domain	PIK_FAT	TRRAP ATM	4.63e-04	6	105	2	IPR014009
Domain	Ins145_P3_rec	RYR1 RYR3	4.63e-04	6	105	2	PF08709
Domain	FATC	TRRAP ATM	4.63e-04	6	105	2	SM01343
Domain	PI3K_Ras-bd_dom	PIK3C2B PIK3CA	6.45e-04	7	105	2	IPR000341
Domain	PI3K_rbd	PIK3C2B PIK3CA	6.45e-04	7	105	2	PF00794
Domain	PI3K_RBD	PIK3C2B PIK3CA	6.45e-04	7	105	2	PS51546
Domain	PI3K_rbd	PIK3C2B PIK3CA	6.45e-04	7	105	2	SM00144
Domain	HEAT_REPEAT	RELCH PPP4R4 MROH2B TANGO6	6.50e-04	70	105	4	PS50077
Domain	Prefoldin	KIF21B KIF21A PPFIA3 RACGAP1	7.24e-04	72	105	4	IPR009053
Domain	PI3K_C2_dom	PIK3C2B PIK3CA	8.57e-04	8	105	2	IPR002420
Domain	PI3K_C2	PIK3C2B PIK3CA	8.57e-04	8	105	2	PF00792
Domain	PI3K_C2	PIK3C2B PIK3CA	8.57e-04	8	105	2	PS51547
Domain	PI3K_C2	PIK3C2B PIK3CA	8.57e-04	8	105	2	SM00142
Domain	PI3Ka	PIK3C2B PIK3CA	1.10e-03	9	105	2	PF00613
Domain	-	PIK3C2B PIK3CA	1.10e-03	9	105	2	1.25.40.70
Domain	PI3Ka	PIK3C2B PIK3CA	1.10e-03	9	105	2	SM00145
Domain	MIR	RYR1 RYR3	1.37e-03	10	105	2	PS50919
Domain	MIR	RYR1 RYR3	1.37e-03	10	105	2	PF02815
Domain	MIR	RYR1 RYR3	1.37e-03	10	105	2	SM00472
Domain	MIR_motif	RYR1 RYR3	1.37e-03	10	105	2	IPR016093
Domain	PIK_HELICAL	PIK3C2B PIK3CA	1.37e-03	10	105	2	PS51545
Domain	PI_Kinase	PIK3C2B PIK3CA	1.37e-03	10	105	2	IPR015433
Domain	PInositide-3_kin_accessory_dom	PIK3C2B PIK3CA	1.37e-03	10	105	2	IPR001263
Domain	Kinesin_motor_CS	KIF21B KIF13B KIF21A	1.58e-03	41	105	3	IPR019821
Domain	Kinesin-like_fam	KIF21B KIF13B KIF21A	1.81e-03	43	105	3	IPR027640
Domain	KINESIN_MOTOR_1	KIF21B KIF13B KIF21A	1.93e-03	44	105	3	PS00411
Domain	-	KIF21B KIF13B KIF21A	1.93e-03	44	105	3	3.40.850.10
Domain	Kinesin_motor_dom	KIF21B KIF13B KIF21A	1.93e-03	44	105	3	IPR001752
Domain	Kinesin	KIF21B KIF13B KIF21A	1.93e-03	44	105	3	PF00225
Domain	KINESIN_MOTOR_2	KIF21B KIF13B KIF21A	1.93e-03	44	105	3	PS50067
Domain	KISc	KIF21B KIF13B KIF21A	1.93e-03	44	105	3	SM00129
Domain	RasGAP	IQGAP1 NF1	2.73e-03	14	105	2	SM00323
Domain	RasGAP_CS	IQGAP1 NF1	2.73e-03	14	105	2	IPR023152
Domain	RasGAP	IQGAP1 NF1	3.13e-03	15	105	2	PF00616
Domain	RAS_GTPASE_ACTIV_1	IQGAP1 NF1	3.13e-03	15	105	2	PS00509
Domain	RAS_GTPASE_ACTIV_2	IQGAP1 NF1	3.13e-03	15	105	2	PS50018
Domain	HEAT_type_2	RELCH PPP4R4	4.03e-03	17	105	2	IPR021133
Domain	Chromodomain_CS	CHD1 CHD2	4.52e-03	18	105	2	IPR023779
Domain	RasGAP_dom	IQGAP1 NF1	4.52e-03	18	105	2	IPR001936
Pathway	REACTOME_RAC2_GTPASE_CYCLE	DOCK3 LBR IQGAP1 PIK3CA RACGAP1 DIAPH3	8.28e-06	88	77	6	M41810
Pubmed	A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.	PRPSAP1 STX8 DYM COPB1 POLD1 PIGS GOSR1 LBR EXOSC2 IQGAP1 BHLHE23 XPO5 CEBPZ EHD1 SMU1 GPR89A RACGAP1 CCAR2 NUP188 ATM IKBKB CNOT3	5.15e-10	1440	108	22	30833792
Pubmed	Duplication and extensive remodeling shaped POTE family genes encoding proteins containing ankyrin repeat and coiled coil domains.	ANKRD26 POTEE POTEI POTEJ	1.09e-08	9	108	4	16364570
Pubmed	Evolution and expression of chimeric POTE-actin genes in the human genome.	POTEF POTEE POTEJ	2.91e-08	3	108	3	17101985
Pubmed	Identification of a novel actin isoform in hepatocellular carcinoma.	POTEF POTEE POTEI POTEJ	1.17e-07	15	108	4	16824795
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	COPB1 CHD1 CHD2 TRRAP IQGAP1 DDX10 NF1 XPO5 CEBPZ SMU1 CCAR2 NUP188 ATM	1.29e-07	653	108	13	22586326
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	KIF13B CYP2A6 POTEF KIF21A ANKRD26 CHD2 PPP4R4 IQGAP1 POTEE RUNDC3A C6orf118 CEBPZ AK1 CCAR2 ATM DIAPH3 POTEI POTEJ	4.75e-07	1442	108	18	35575683
Pubmed	An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.	KIF13B GPR89B RELCH PDE8A POLD1 PIGS CDH23 EXOSC2 IQGAP1 PTPN14 NF1 XPO5 SMU1 SLC35F6 CCAR2 ACAP2 DCLK1	6.77e-07	1321	108	17	27173435
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	EEFSEC GPR89B POLD1 GOSR1 CHD1 CHD2 TEKT5 TRRAP EXOSC2 IQGAP1 DDX10 POTEE CEBPZ SMU1 SLC35F6 CNOT3 DCLK1 ZMYM4	8.15e-07	1497	108	18	31527615
Pubmed	HIV-1 Tat protein down-regulates CREB transcription factor expression in PC12 neuronal cells through a phosphatidylinositol 3-kinase/AKT/cyclic nucleoside phosphodiesterase pathway.	PDE4D PDE8A PIK3C2B PIK3CA	1.46e-06	27	108	4	11156964
Pubmed	Unbiased Identification of trans Regulators of ADAR and A-to-I RNA Editing.	POLD1 POTEF DDX10 POTEE CEBPZ CCAR2 POTEI POTEJ	2.20e-06	271	108	8	32433965
Pubmed	Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.	KIF13B ANKRD26 POTEE YEATS2 PTPN14 PIK3C2B DIAPH3 POTEI POTEJ CNOT3 ZMYM4	2.31e-06	588	108	11	38580884
Pubmed	Voltage-dependent conformational changes of Kv1.3 channels activate cell proliferation.	GPR89B COPB1 CHD2 RYR1 YEATS2 CTNNA3 GPR89A	4.14e-06	208	108	7	33230847
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	COPB1 POLD1 KIF21A CHD1 CHD2 LBR TRRAP IQGAP1 DDX10 PTPN14 NF1 CEBPZ EHD1 SMU1 RACGAP1 CCAR2	4.41e-06	1353	108	16	29467282
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	KIF21B RELCH ABCA2 KIF21A LRRK1 IQGAP1 RACGAP1 NUP188 ACAP2 ZMYM4	6.22e-06	529	108	10	14621295
Pubmed	cAMP-specific phosphodiesterases 8A and 8B, essential regulators of Leydig cell steroidogenesis.	PDE8A PDE8B	9.55e-06	2	108	2	22232524
Pubmed	Novel dendritic kinesin sorting identified by different process targeting of two related kinesins: KIF21A and KIF21B.	KIF21B KIF21A	9.55e-06	2	108	2	10225949
Pubmed	Contractile impairment and structural alterations of skeletal muscles from knockout mice lacking type 1 and type 3 ryanodine receptors.	RYR1 RYR3	9.55e-06	2	108	2	9489997
Pubmed	The high-affinity cAMP-specific phosphodiesterase 8B controls steroidogenesis in the mouse adrenal gland.	PDE8A PDE8B	9.55e-06	2	108	2	21187369
Pubmed	The block of ryanodine receptors selectively inhibits fetal myoblast differentiation.	RYR1 RYR3	9.55e-06	2	108	2	12640042
Pubmed	A primate-specific POTE-actin fusion protein plays a role in apoptosis.	POTEF POTEE	9.55e-06	2	108	2	19669888
Pubmed	Possible involvement of ryanodine receptor-mediated intracellular calcium release in the effect of corticotropin-releasing factor on adrenocorticotropin secretion.	RYR1 RYR3	9.55e-06	2	108	2	14592949
Pubmed	GPHR-dependent functions of the Golgi apparatus are essential for the formation of lamellar granules and the skin barrier.	GPR89B GPR89A	9.55e-06	2	108	2	22572823
Pubmed	Morphological abnormalities of adrenal gland and hypertrophy of liver in mutant mice lacking ryanodine receptors.	RYR1 RYR3	9.55e-06	2	108	2	9799464
Pubmed	The receptor protein-tyrosine phosphatase PTPmu interacts with IQGAP1.	IQGAP1 PTPRM	9.55e-06	2	108	2	16380380
Pubmed	GPHR is a novel anion channel critical for acidification and functions of the Golgi apparatus.	GPR89B GPR89A	9.55e-06	2	108	2	18794847
Pubmed	Comparison of enzymatic characterization and gene organization of cyclic nucleotide phosphodiesterase 8 family in humans.	PDE8A PDE8B	9.55e-06	2	108	2	12681444
Pubmed	Phosphatidylinositol 3-kinase mediates activation of ATM by high NaCl and by ionizing radiation: Role in osmoprotective transcriptional regulation.	PIK3CA ATM	9.55e-06	2	108	2	16728507
Pubmed	cAMP-specific phosphodiesterase 8A and 8B isoforms are differentially expressed in human testis and Leydig cell tumor.	PDE8A PDE8B	9.55e-06	2	108	2	36277728
Pubmed	Expression and functional activity of ryanodine receptors (RyRs) during skeletal muscle development.	RYR1 RYR3	9.55e-06	2	108	2	17118445
Pubmed	RyR3 amplifies RyR1-mediated Ca(2+)-induced Ca(2+) release in neonatal mammalian skeletal muscle.	RYR1 RYR3	9.55e-06	2	108	2	11500519
Pubmed	NF1 patient missense variants predict a role for ATM in modifying neurofibroma initiation.	NF1 ATM	9.55e-06	2	108	2	31664505
Pubmed	DBC2, a candidate for a tumor suppressor gene involved in breast cancer.	RHOBTB2 CCAR2	9.55e-06	2	108	2	12370419
Pubmed	CHD1 and CHD2 are positive regulators of HIV-1 gene expression.	CHD1 CHD2	9.55e-06	2	108	2	25297984
Pubmed	Principal mutation hotspot for central core disease and related myopathies in the C-terminal transmembrane region of the RYR1 gene.	RYR1 RYR3	9.55e-06	2	108	2	12565913
Pubmed	Functional and morphological features of skeletal muscle from mutant mice lacking both type 1 and type 3 ryanodine receptors.	RYR1 RYR3	9.55e-06	2	108	2	9192302
Pubmed	Isolation and partial cloning of ryanodine-sensitive Ca2+ release channel protein isoforms from human myometrial smooth muscle.	RYR1 RYR3	9.55e-06	2	108	2	7556644
Pubmed	Selective POTE paralogs on chromosome 2 are expressed in human embryonic stem cells.	POTEE POTEJ	9.55e-06	2	108	2	18447647
Pubmed	Ryanodine receptors in muscarinic receptor-mediated bronchoconstriction.	RYR1 RYR3	9.55e-06	2	108	2	15894801
Pubmed	Effect of calmodulin on Ca2+-induced Ca2+ release of skeletal muscle from mutant mice expressing either ryanodine receptor type 1 or type 3.	RYR1 RYR3	9.55e-06	2	108	2	9817784
Pubmed	Intestinal tuft cells regulate the ATM mediated DNA Damage response via Dclk1 dependent mechanism for crypt restitution following radiation injury.	ATM DCLK1	9.55e-06	2	108	2	27876863
Pubmed	Macrophage DCLK1 promotes atherosclerosis via binding to IKKβ and inducing inflammatory responses.	IKBKB DCLK1	9.55e-06	2	108	2	36896602
Pubmed	The Vertebrate Genome Annotation browser 10 years on.	POTEB3 CYP11A1 POTEF POTEE POTEI POTEJ	1.25e-05	163	108	6	24316575
Pubmed	140 mouse brain proteins identified by Ca2+-calmodulin affinity chromatography and tandem mass spectrometry.	KIF21B RELCH KIF21A PPFIA3 NF1 DCLK1	1.25e-05	163	108	6	16512683
Pubmed	Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.	COPB1 POLD1 KIF21A IQGAP1 NF1 XPO5 EHD1 RACGAP1 ATM DIAPH3	1.42e-05	582	108	10	20467437
Pubmed	Akt/Nox2/NF-κB signaling pathway is involved in Tat-induced HIV-1 long terminal repeat (LTR) transactivation.	PIK3C2B PIK3CA IKBKB	1.58e-05	16	108	3	21029719
Pubmed	Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV.	ANXA4 PIGS GOSR1 TOM1L1 NF1 PTPRM XPO5 SLC35F6 GPR89A CCAR2 NUP188 ATM RMND1	2.61e-05	1061	108	13	33845483
Pubmed	Stasimon/Tmem41b localizes to mitochondria-associated ER membranes and is essential for mouse embryonic development.	GPR89B COPB1 LBR XPO5 GPR89A	2.83e-05	113	108	5	30352685
Pubmed	Rosette-forming glioneuronal tumors share a distinct DNA methylation profile and mutations in FGFR1, with recurrent co-mutation of PIK3CA and NF1.	NF1 PIK3CA	2.86e-05	3	108	2	31250151
Pubmed	Type 1 and type 3 ryanodine receptors are selectively involved in muscarinic antinociception in mice: an antisense study.	RYR1 RYR3	2.86e-05	3	108	2	18403125
Pubmed	Characterization and mapping of the 12 kDa FK506-binding protein (FKBP12)-binding site on different isoforms of the ryanodine receptor and of the inositol 1,4,5-trisphosphate receptor.	RYR1 RYR3	2.86e-05	3	108	2	11171121
Pubmed	The ryanodine receptor/calcium channel genes are widely and differentially expressed in murine brain and peripheral tissues.	RYR1 RYR3	2.86e-05	3	108	2	7876312
Pubmed	Bidirectional coupling between ryanodine receptors and Ca2+ release-activated Ca2+ (CRAC) channel machinery sustains store-operated Ca2+ entry in human T lymphocytes.	RYR1 RYR3	2.86e-05	3	108	2	22948152
Pubmed	Developmental changes in expression of the three ryanodine receptor mRNAs in the mouse brain.	RYR1 RYR3	2.86e-05	3	108	2	10788707
Pubmed	Ca(2+)-induced Ca2+ release in myocytes from dyspedic mice lacking the type-1 ryanodine receptor.	RYR1 RYR3	2.86e-05	3	108	2	7621815
Pubmed	Molecular identification of the ryanodine receptor pore-forming segment.	RYR1 RYR3	2.86e-05	3	108	2	10473538
Pubmed	CHD1 and SPOP synergistically protect prostate epithelial cells from DNA damage.	CHD1 CHD2	2.86e-05	3	108	2	33022763
Pubmed	Differential alterations in expressions of ryanodine receptor subtypes in cerebellar cortical neurons of an ataxic mutant, rolling mouse Nagoya.	RYR1 RYR3	2.86e-05	3	108	2	18313230
Pubmed	Heterogeneous gene expression and functional activity of ryanodine receptors in resistance and conduit pulmonary as well as mesenteric artery smooth muscle cells.	RYR1 RYR3	2.86e-05	3	108	2	18434746
Pubmed	Adherens junction engagement regulates functional patterning of the cardiac pacemaker cell lineage.	HCN4 CTNNA3	2.86e-05	3	108	2	33891897
Pubmed	SPRY domains in ryanodine receptors (Ca(2+)-release channels).	RYR1 RYR3	2.86e-05	3	108	2	9204703
Pubmed	Predictive Value of the TP53/PIK3CA/ATM Mutation Classifier for Patients With Bladder Cancer Responding to Immune Checkpoint Inhibitor Therapy.	PIK3CA ATM	2.86e-05	3	108	2	34421886
Pubmed	Ryanodine receptors are expressed in epidermal keratinocytes and associated with keratinocyte differentiation and epidermal permeability barrier homeostasis.	RYR1 RYR3	2.86e-05	3	108	2	21881589
Pubmed	Isoform-dependent formation of heteromeric Ca2+ release channels (ryanodine receptors).	RYR1 RYR3	2.86e-05	3	108	2	12213830
Pubmed	Expression of the ryanodine receptor type 3 calcium release channel during development and differentiation of mammalian skeletal muscle cells.	RYR1 RYR3	2.86e-05	3	108	2	9242641
Pubmed	Genetic and structural studies of RABL3 reveal an essential role in lymphoid development and function.	GPR89B GPR89A	2.86e-05	3	108	2	32220963
Pubmed	Calcineurin upregulates local Ca(2+) signaling through ryanodine receptor-1 in airway smooth muscle cells.	RYR1 RYR3	2.86e-05	3	108	2	25239916
Pubmed	A gene-specific cerebral types 1, 2, and 3 RyR protein knockdown induces an antidepressant-like effect in mice.	RYR1 RYR3	2.86e-05	3	108	2	18643873
Pubmed	Identification of mutations in the cardiac ryanodine receptor gene in families affected with arrhythmogenic right ventricular cardiomyopathy type 2 (ARVD2).	RYR1 RYR3	2.86e-05	3	108	2	11159936
Pubmed	Chromosomal localization of murine ryanodine receptor genes RYR1, RYR2, and RYR3 by in situ hybridization.	RYR1 RYR3	2.86e-05	3	108	2	7959768
Pubmed	The organization of proteins in the human red blood cell membrane. A review.	RYR1 RYR3	2.86e-05	3	108	2	4600883
Pubmed	Regulation of mouse egg activation: presence of ryanodine receptors and effects of microinjected ryanodine and cyclic ADP ribose on uninseminated and inseminated eggs.	RYR1 RYR3	2.86e-05	3	108	2	7635066
Pubmed	Mouse screen reveals multiple new genes underlying mouse and human hearing loss.	KIF21B KIF13B STX8 CYP11A1 CDH23 TRRAP PABIR3 RHD NF1 EHD1 SLC35F6 IKBKB DCLK1 DOP1B	3.12e-05	1242	108	14	30973865
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	ADCY3 SNX13 YEATS2 XPO5 BTBD7 RHOBTB2 CCAR2 DOP1B	4.17e-05	407	108	8	12693553
Pubmed	A high-throughput approach for measuring temporal changes in the interactome.	PRPSAP1 RELCH PDE4D COPB1 POLD1 KIF21A TOM1L1 EXOSC2 IQGAP1 XPO5 EHD1 CCAR2 NUP188 IKBKB RABGGTA	4.44e-05	1455	108	15	22863883
Pubmed	Characterization of the binding sites for the interactions between FKBP12 and intracellular calcium release channels.	RYR1 RYR3	5.71e-05	4	108	2	22100703
Pubmed	A genome-wide survey of RAS transformation targets.	DDX10 RACGAP1	5.71e-05	4	108	2	10655059
Pubmed	Ryanodine receptor calcium release channels: lessons from structure-function studies.	RYR1 RYR3	5.71e-05	4	108	2	23413940
Pubmed	Partial cloning and differential expression of ryanodine receptor/calcium-release channel genes in human tissues including the hippocampus and cerebellum.	RYR1 RYR3	5.71e-05	4	108	2	9607712
Pubmed	Deubiquitinase USP47-stabilized splicing factor IK regulates the splicing of ATM pre-mRNA.	SMU1 ATM	5.71e-05	4	108	2	32377397
Pubmed	Nf1-/- Schwann cell-conditioned medium modulates mast cell degranulation by c-Kit-mediated hyperactivation of phosphatidylinositol 3-kinase.	NF1 PIK3CA	5.71e-05	4	108	2	21037083
Pubmed	Conserved and divergent functions of Nfix in skeletal muscle development during vertebrate evolution.	RYR1 RYR3	5.71e-05	4	108	2	23482488
Pubmed	GATE-16, a membrane transport modulator, interacts with NSF and the Golgi v-SNARE GOS-28.	COPB1 GOSR1	5.71e-05	4	108	2	10747018
Pubmed	Characterization of the CHD family of proteins.	CHD1 CHD2	5.71e-05	4	108	2	9326634
Pubmed	A glutathione deficit alters dopamine modulation of L-type calcium channels via D2 and ryanodine receptors in neurons.	RYR1 RYR3	5.71e-05	4	108	2	18206662
Pubmed	Cooperative activation of PI3K by Ras and Rho family small GTPases.	PIK3CA RACGAP1	5.71e-05	4	108	2	22683270
Pubmed	Requirement for the ryanodine receptor type 3 for efficient contraction in neonatal skeletal muscles.	RYR1 RYR3	5.71e-05	4	108	2	9384575
Pubmed	Molecular linkage between the kinase ATM and NF-kappaB signaling in response to genotoxic stimuli.	ATM IKBKB	5.71e-05	4	108	2	16497931
Pubmed	Remodeling of ryanodine receptor complex causes "leaky" channels: a molecular mechanism for decreased exercise capacity.	PDE4D RYR1	5.71e-05	4	108	2	18268335
Pubmed	Essential roles of PI(3)K-p110beta in cell growth, metabolism and tumorigenesis.	PIK3C2B PIK3CA	5.71e-05	4	108	2	18594509
Pubmed	Cerebellar Neurodegeneration and Neuronal Circuit Remodeling in Golgi pH Regulator-Deficient Mice.	GPR89B GPR89A	5.71e-05	4	108	2	31118204
Pubmed	MYC multimers shield stalled replication forks from RNA polymerase.	POLD1 CHD1 LBR EXOSC2 IQGAP1 DDX10 XPO5 CEBPZ MRFAP1 SLC35F6 RACGAP1 CCAR2	5.97e-05	989	108	12	36424410
Pubmed	Overview of PDEs and their regulation.	PDE4D PDE8A PDE8B	6.37e-05	25	108	3	17307970
Pubmed	Substrate specificities and identification of putative substrates of ATM kinase family members.	POLD1 PIK3CA ATM	6.37e-05	25	108	3	10608806
Pubmed	The Functional Proximal Proteome of Oncogenic Ras Includes mTORC2.	KIF13B RELCH ANKRD26 PTPN14 NF1 PTPRM PIK3CA EHD1 DIAPH3	7.34e-05	569	108	9	30639242
Pubmed	Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.	POLD1 ANXA4 CHD1 CHD2 TRRAP EXOSC2 IQGAP1 XPO5 SMU1 AK1 CCAR2 ATM	7.56e-05	1014	108	12	32416067
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	KIF13B POTEF ANKRD26 LBR PPP4R4 PTPN14 NF1 PIK3C2B RACGAP1 DCLK1 DOP1B	7.82e-05	861	108	11	36931259
Pubmed	ZBTB2 protein is a new partner of the Nucleosome Remodeling and Deacetylase (NuRD) complex.	COPB1 KIF21A CHD1 LBR DDX10 CEBPZ SMU1	7.98e-05	330	108	7	33301849
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	COPB1 CHD1 LBR TRRAP IQGAP1 DDX10 NF1 CEBPZ SMU1 RACGAP1 CCAR2 NUP188	8.30e-05	1024	108	12	24711643
Pubmed	Loss of Function Genetic Screen Identifies ATM Kinase as a Positive Regulator of TLR3-Mediated NF-κB Activation.	ATM IKBKB	9.50e-05	5	108	2	32731169
Pubmed	Alterations in p53, BRCA1, ATM, PIK3CA, and HER2 genes and their effect in modifying clinicopathological characteristics and overall survival of Bulgarian patients with breast cancer.	PIK3CA ATM	9.50e-05	5	108	2	20177704
Cytoband	2q21.1	POTEF POTEE POTEI POTEJ	1.11e-05	58	108	4	2q21.1
Cytoband	11q22-q23	DDX10 ATM	8.17e-05	6	108	2	11q22-q23
Cytoband	Ensembl 112 genes in cytogenetic band chr2q21	POTEF POTEE POTEI POTEJ	4.62e-04	151	108	4	chr2q21
GeneFamily	Ankyrin repeat domain containing\|POTE ankyrin domain containing	POTEF POTEE POTEI POTEJ	1.52e-07	13	71	4	685
GeneFamily	Ryanodine receptors\|Protein phosphatase 1 regulatory subunits	RYR1 RYR3	4.55e-05	3	71	2	287
GeneFamily	Phosphodiesterases	PDE4D PDE8A PDE8B	1.11e-04	24	71	3	681
GeneFamily	Ankyrin repeat domain containing	POTEF ANKRD26 POTEE POTEI POTEJ ACAP2	3.74e-04	242	71	6	403
GeneFamily	Phosphatidylinositol 3-kinase subunits	PIK3C2B PIK3CA	4.19e-04	8	71	2	831
GeneFamily	Kinesins\|Pleckstrin homology domain containing	KIF21B KIF13B KIF21A	7.80e-04	46	71	3	622
GeneFamily	WD repeat domain containing	KIF21B NBEAL1 KIF21A TEP1 SMU1	3.68e-03	262	71	5	362
ToppCell	Children_(3_yrs)-Epithelial-lung_neuroendocrine_cell_(PNEC)-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	DOCK3 HCN4 RUNDC3A CTNNA3 POTEI POTEJ	3.01e-06	164	108	6	be49af6335f2505065cde2cb9800e4a5516811b1
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	KIF13B CYP2A6 PDE4D PTPN14 SCNN1A CHSY3	4.83e-06	178	108	6	f5ed4a6e3eb8056b1be1fb311021710c95bdf888
ToppCell	CD8+_Memory_T_cell-CV-7\|CD8+_Memory_T_cell / cell class, Virus stimulation and cluster	KIF13B GPR89B OSTM1 LBR IQGAP1 DOP1B	7.23e-06	191	108	6	9454f642c3621370fa23640b631301346b300950
ToppCell	AT2_cells-Donor_02\|World / lung cells shred on cell class, cell subclass, sample id	PDE4D NECAB1 PDE8B RHOBTB2 SCNN1A AK1	7.67e-06	193	108	6	8187f976fd2d11fad3286690f1a046e894772220
Drug	Cinoxacin [28657-80-9]; Down 200; 15.2uM; PC3; HT_HG-U133A	ANKRD26 ST6GAL1 LRRK1 CITED2 LINS1 NF1 BTBD7 AK1	3.44e-06	195	105	8	5783_DN
Drug	cnicin	KIF13B BHLHE23 NF1 PIK3C2B PIK3CA ACAP2	4.31e-06	92	105	6	CID000091176
Drug	felodipine	CYP2A6 PDE4D PDE8A CYP11A1 RYR1 RYR3 PDE8B	1.35e-05	169	105	7	CID000003333
Drug	M3/M4	CYP2A6 RYR1 RYR3 BHLHE23	1.39e-05	32	105	4	CID000486507
Drug	papaverine	PDE4D PDE8A PLCD4 ADCY3 RYR1 RYR3 PDE8B	1.76e-05	176	105	7	CID000004680
Drug	5'-adenylyl (beta,gamma-methylene)diphosphonate	RYR1 RYR3	2.11e-05	2	105	2	ctd:C005147
Drug	Acetopromazine maleate salt [3598-37-6]; Down 200; 9uM; MCF7; HT_HG-U133A	GOSR1 PPFIA3 TEP1 EXOSC2 RHOBTB2 EHD1 ATM	3.29e-05	194	105	7	6832_DN
Drug	9-beta-D-arabinofuranosylguanine	EEFSEC PDE4D PDE8A COPB1 POLD1 PLCD4 ADCY3 TLR8 SNX13 IQGAP1 NF1 ART3 PDE8B RHOBTB2	3.29e-05	843	105	14	CID000000765
Drug	bimoclomol	RYR1 RYR3 IKBKB	3.34e-05	14	105	3	CID009576891
Drug	orthovanadate	KIF13B PDE4D PDE8A COPB1 ADCY3 RYR1 TSPAN16 ART3 PIK3CA PDE8B	3.35e-05	435	105	10	CID000061672
Drug	Chicago sky blue 6B [2610-05-1]; Up 200; 4uM; MCF7; HT_HG-U133A	PPFIA3 PPP4R4 SNX13 NF1 RHOBTB2 NUP188 ATM	3.40e-05	195	105	7	3266_UP
Drug	STOCK1N-35874; Up 200; 14uM; PC3; HT_HG-U133A	ST6GAL1 TRRAP EXOSC2 BTBD7 RHOBTB2 RMND1 IKBKB	3.40e-05	195	105	7	6583_UP
Drug	Clebopride maleate [84370-95-6]; Up 200; 8.2uM; PC3; HT_HG-U133A	LRRK1 CITED2 PTPN14 BTBD7 EHD1 SLC35F6 IKBKB	3.63e-05	197	105	7	6311_UP
Drug	Meglumine [6284-40-8]; Down 200; 20.4uM; HL60; HT_HG-U133A	PDE8A LRRK1 EXOSC2 ADCY3 PIK3C2B BTBD7 SLC35F6	3.63e-05	197	105	7	3068_DN
Drug	Fluorometholone [426-13-1]; Down 200; 10.6uM; PC3; HT_HG-U133A	ANKRD26 TEP1 CITED2 NF1 BTBD7 RHOBTB2 ATM	3.63e-05	197	105	7	5771_DN
Drug	Diprophylline [479-18-5]; Up 200; 15.8uM; MCF7; HT_HG-U133A	ABCA2 TRRAP RYR1 SNX13 PTPN14 NF1 AK1	3.75e-05	198	105	7	1689_UP
Drug	Hymecromone [90-33-5]; Down 200; 22.8uM; MCF7; HT_HG-U133A	ADCY3 PPP4R4 PTPN14 NF1 BTBD7 EHD1 AK1	3.75e-05	198	105	7	5684_DN
Drug	Ciprofibrate [52214-84-3]; Down 200; 13.8uM; PC3; HT_HG-U133A	ABCA2 ANKRD26 LRRK1 PPP4R4 NF1 SLC35F6 CNOT3	3.87e-05	199	105	7	5740_DN
Drug	Methyldopa (L,-) [555-30-6]; Down 200; 19uM; MCF7; HT_HG-U133A	KIF13B ABCA2 PPP4R4 NF1 PDE8B BTBD7 RHOBTB2	3.87e-05	199	105	7	5637_DN
Drug	AC1OAGFB	CDH23 PLCD4 TRRAP ADCY3 BHLHE23 ART3 PIK3C2B PIK3CA SCNN1A IKBKB ACAP2	3.96e-05	539	105	11	CID006857345
Drug	zaprinast	PDE4D PDE8A ADCY3 RYR1 RYR3 PDE8B	4.93e-05	141	105	6	CID000005722
Drug	caffeine	CYP2A6 PDE4D DYM PDE8A CYP11A1 PLCD4 ADCY3 RYR1 RYR3 PDE8B ATM	5.77e-05	562	105	11	CID000002519
Drug	DiBP	CYP11A1 LBR SIL1	6.18e-05	17	105	3	CID000006782
Drug	forskolin from Coleus forskohlii	STX8 PDE4D PDE8A CYP11A1 PLCD4 ADCY3 RYR1 RYR3 BHLHE23 NF1 ART3 PIK3C2B PIK3CA PDE8B SCNN1A	6.26e-05	1013	105	15	CID000003413
Drug	cis-diammineplatinum(II	RYR1 RYR3	6.30e-05	3	105	2	CID000159790
Drug	2-hydroxyheptanoic acid	RYR1 RYR3	6.30e-05	3	105	2	CID002750949
Drug	8N3-cADPR	RYR1 RYR3	6.30e-05	3	105	2	CID000127713
Drug	aminodantrolene	RYR1 RYR3	6.30e-05	3	105	2	CID009570289
Drug	E 4021	PDE8A PDE8B	6.30e-05	3	105	2	ctd:C091517
Drug	2-hydroxycarbazole	RYR1 RYR3	6.30e-05	3	105	2	CID000093551
Drug	1,1'-diheptyl-4,4'-bipyridinium	RYR1 RYR3	6.30e-05	3	105	2	CID000080262
Drug	flubendiamide	RYR1 RYR3	6.30e-05	3	105	2	CID011193251
Drug	Ryanodyl 3-(pyridine-3-carboxylate	RYR1 RYR3	6.30e-05	3	105	2	CID005748312
Drug	MDL-899	RYR1 RHD	6.30e-05	3	105	2	CID000071143
Drug	VTCs	COPB1 ANXA4 GOSR1 TRRAP	1.13e-04	54	105	4	CID000006413
Drug	AA-2379	PDE4D PDE8A PDE8B	1.19e-04	21	105	3	CID000128390
Drug	A-30	RYR1 RYR3	1.26e-04	4	105	2	CID003028528
Drug	PCB74	RYR1 RYR3	1.26e-04	4	105	2	CID000036218
Drug	148504-47-6	RYR1 RYR3	1.26e-04	4	105	2	CID006444275
Drug	Bastadin 10	RYR1 RYR3	1.26e-04	4	105	2	CID009589366
Drug	SC 38249	RYR1 RYR3	1.26e-04	4	105	2	CID000134834
Drug	AC1L1U7A	RYR1 RYR3	1.26e-04	4	105	2	CID000035682
Drug	HWA 153	PDE4D PDE8A PDE8B	1.38e-04	22	105	3	CID000162797
Drug	lavendustin A	TOM1L1 RYR1 RYR3 PIK3C2B PIK3CA IKBKB	1.43e-04	171	105	6	CID000003894
Disease	congenital myopathy 1A (implicated_via_orthology)	RYR1 RYR3	3.34e-05	3	99	2	DOID:3529 (implicated_via_orthology)
Disease	malignant hyperthermia (implicated_via_orthology)	RYR1 RYR3	3.34e-05	3	99	2	DOID:8545 (implicated_via_orthology)
Disease	X-12063 measurement	PDE8A ANKRD26 SIL1 NF1 NECAB1 RACGAP1	3.99e-05	186	99	6	EFO_0021283
Disease	response to angiotensin-converting enzyme inhibitor, response to angiotensin receptor blocker, angioedema	PDE4D DIAPH3 DCLK1	9.01e-05	26	99	3	EFO_0005325, EFO_0005532, EFO_0010735
Disease	Prostatic Neoplasms	CYP2A6 PDE4D ANXA4 TOM1L1 CHD1 SIL1 PIK3CA ATM CNOT3	2.32e-04	616	99	9	C0033578
Disease	Malignant neoplasm of prostate	CYP2A6 PDE4D ANXA4 TOM1L1 CHD1 SIL1 PIK3CA ATM CNOT3	2.32e-04	616	99	9	C0376358
Disease	Cutaneous Melanoma	TRRAP NF1 PIK3CA	3.56e-04	41	99	3	C0151779
Disease	Gastric Adenocarcinoma	TRRAP ATM DCLK1	4.69e-04	45	99	3	C0278701
Disease	Neoplasm of lung	CYP2A6 PIK3CA	9.88e-04	14	99	2	cv:C0024121
Disease	Lung cancer	CYP2A6 PIK3CA	9.88e-04	14	99	2	cv:C0242379
Disease	LUNG CANCER	CYP2A6 PIK3CA	9.88e-04	14	99	2	211980
Disease	Sarcoma, Spindle Cell	NF1 PIK3CA	9.88e-04	14	99	2	C0205945
Disease	Sarcoma, Epithelioid	NF1 PIK3CA	9.88e-04	14	99	2	C0205944
Disease	adverse effect, response to xenobiotic stimulus	ABCA2 CTNNA3 SCNN1A	1.04e-03	59	99	3	EFO_0009658, GO_0009410
Disease	Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse	AK1 ATM	1.30e-03	16	99	2	C0334634
Disease	Benign neoplasm of stomach	PIK3CA ATM	1.47e-03	17	99	2	C0153943
Disease	Neoplasm of uncertain or unknown behavior of stomach	PIK3CA ATM	1.47e-03	17	99	2	C0496905
Disease	Carcinoma in situ of stomach	PIK3CA ATM	1.47e-03	17	99	2	C0154060
Disease	Conventional (Clear Cell) Renal Cell Carcinoma	ANXA4 RYR1 PIK3CA ATM	1.58e-03	148	99	4	C0279702
Disease	breast cancer (is_implicated_in)	XPO5 PIK3CA ATM IKBKB	1.66e-03	150	99	4	DOID:1612 (is_implicated_in)
Disease	BREAST CANCER	PIK3CA ATM	2.24e-03	21	99	2	114480
Disease	Stomach Carcinoma	PIK3CA ATM	2.24e-03	21	99	2	C0699791
Disease	Sarcoma	NF1 PIK3CA	2.24e-03	21	99	2	C1261473
Disease	Colorectal Neoplasms	CYP2A6 POLD1 CHD1 PIK3CA DCLK1	2.45e-03	277	99	5	C0009404
Disease	Colorectal Carcinoma	CYP2A6 RELCH POLD1 CHD1 NF1 PIK3CA DCLK1 ZMYM4	2.53e-03	702	99	8	C0009402
Disease	Glioma	NF1 PIK3CA ATM	3.17e-03	87	99	3	C0017638
Disease	hepatocellular carcinoma (is_implicated_in)	TEP1 RYR3 XPO5 PIK3CA	3.28e-03	181	99	4	DOID:684 (is_implicated_in)

Protein segments in the cluster

Peptide	Gene	Start	Entry
EVMVLAELFLEMLQR	CCAR2	536	Q8N163
MLLVALLVCLTVMVL	CYP2A6	6	P11509
EMVRMVRAATLIQAL	IQCD	396	Q96DY2
ILMQAQALDEMRRLV	BHLHE23	151	Q8NDY6
DIVTLLRLARMNEEM	ACAP2	721	Q15057
VMVSRAEIDMLDIRA	ANXA4	271	P09525
MLQEEIAMLRLEIDT	ANKRD26	916	Q9UPS8
RIELVESVIMLNMEK	CCDC180	1071	Q9P1Z9
EIRMMILEVDETRLA	DIAPH3	736	Q9NSV4
DMSALQMAIIVLAIL	CDH23	3061	Q9H251
RVLIFSQMVRMLDIL	CHD1	806	O14646
RMLETILRMLDNDSI	CNOT3	181	O75175
ELDLMKMREEVITLI	IQGAP1	886	P46940
LMDVNVLMAVQLLIE	NBEAL1	971	Q6ZS30
MVSMQAAEEIRILAV	IQCN	916	Q9H0B3
LVMLLAEMKIQDRAV	LBR	401	Q14739
PMMLVNLVVEDRTIS	OR5D16	81	Q8NGK9
QLLLMETTAMLDLLV	PABIR3	151	Q6P4D5
METVIQRELLERVKM	RELCH	1031	Q9P260
LREEIAMLRLELDTM	POTEF	651	A5A3E0
MFETMAIEIEQLLAR	GOSR1	66	O95249
REVMLLQLTVIKVMT	LINS1	86	Q8NG48
KLLVERMMALQTDIV	IKBKB	531	O14920
FIARMLISLAEMDLQ	LRRK1	1031	Q38SD2
LVPLETVLDMLRDAM	AK1	66	P00568
LMVTMLTERERLLET	PPFIA3	31	O75145
VKSVEVLIRIMMQLV	DOP1B	1346	Q9Y3R5
KELITMMLLVDVDQR	DCLK1	621	O15075
FRNICLLIILMVVME	DSG4	6	Q86SJ6
LLIILMVVMEVNSEF	DSG4	11	Q86SJ6
ILVMPIEDQLTQIMR	PCMTD1	186	Q96MG8
AVLMNLVIILLMILD	OR14K1	36	Q8NGZ2
IQMGLLMITRAIVLI	OR51F1	151	A6NGY5
SLRKMVIDIVLATDM	PDE4D	561	Q08499
TLRQGIIDMVLATEM	PDE8A	656	O60658
LRQAIIDMVLATEMT	PDE8B	716	O95263
FDNLRMLIVEKMLEV	COPB1	431	P53618
MTIVNLEADMERLIK	KIF21B	931	O75037
LLMADRMQIVVILSE	OSTM1	146	Q86WC4
IMEEIVMETRQRLLE	EXOSC2	276	Q13868
DLTMLLLMVGNLIII	HCN4	266	Q9Y3Q4
DLRQDMLTLQIIRIM	PIK3CA	806	P42336
DDLRQDMLTLQMIRI	PIK3C2B	1086	O00750
NSMLREEIAMLRLEL	POTEB3	526	A0JP26
LLILETFLMTVLTRM	SLC51A	301	Q86UW1
LREEIAMLRLELDTM	POTEE	651	Q6S8J3
AVTRLLILADMIDVM	CTNNA3	131	Q9UI47
EPIMALRTVILEILM	ATM	2221	Q13315
LRTVILEILMEKEMD	ATM	2226	Q13315
EMMVESLLDVLLQTL	DOCK3	901	Q8IZD9
IEAPIRMMITSQDVL	MT-CO2	146	P00403
MLARTDMENLVLPIL	DYM	366	Q7RTS9
NVIEEVIRMMLEIIN	DYM	526	Q7RTS9
ILALERRLLQTMDMI	GPR89A	186	B7ZAQ6
ILALERRLLQTMDMI	GPR89B	186	P0CG08
LIFSQMVRMLDILAE	CHD2	811	O14647
MDLAREELRMLVTAT	C6orf118	331	Q5T5N4
NLLLAVTMLMVDAVV	ABCA2	891	Q9BZC7
LAIFILVMANVVDML	ADCY3	711	O60266
RIAELEMTIFLINML	CYP11A1	466	P05108
VLDEMMVEQTDLVRL	BTBD7	586	Q9P203
IPRDVNTAVMELLIM	PRPSAP1	66	Q14558
LQMLVLDEADRILDM	DDX10	216	Q13206
LANDIARLMVMVRQE	EHD1	386	Q9H4M9
VVEMAELVFDLLVIM	SCNN1A	566	P37088
DMVVMLLSLLEGNVV	RYR1	4021	P21817
RLLERLMVLVNAVEM	POLD1	521	P28340
DRMAAMILLIQDDAV	CEBPZ	246	Q03701
IVIDIMLDMAEREGV	PTPRM	1106	P28827
DMVRVMEVFLAQLRL	PIGS	381	Q96S52
EIAKMAEMLVELVRR	MRFAP1	106	Q9Y605
LEMRLTLTEERNAVM	KIF13B	1131	Q9NQT8
IMLRDEATILTGMLI	RUNDC3A	161	Q59EK9
NIPLRVMLLLMDEVF	SNX13	781	Q9Y5W8
GREMQERIMDLLVVV	TOM1L1	246	O75674
AIVKRTVLELDRMEM	PPP4R4	666	Q6NUP7
VLVPELAMLRFVVMD	PLCD4	691	Q9BRC7
LVGSRMEILLLMVDD	RABGGTA	266	Q92696
LEDSIIEREMMIRNL	PTPN14	836	Q15678
AELVVAVLRDMRMLE	PYDC1	66	Q8WXC3
IAELLEVFDLRMMVA	RHOBTB2	451	Q9BYZ6
NSMLREEIAMLRLEL	POTEJ	611	P0CG39
VVIETDMQIMVRLIN	SIL1	176	Q9H173
LGIIIMMTLCDQVDI	ST6GAL1	326	P15907
MIVILITIEVMFELG	RMND1	431	Q9NWS8
ENTIMLLERSIMAKE	TEKT5	371	Q96M29
LREEIAMLRLELDTM	POTEI	651	P0CG38
TLLTMQTMLRLAEDE	MROH2B	131	Q7Z745
LERQIQLIREMLMCD	RACGAP1	96	Q9H0H5
EVLMSLVIEMGLDRI	CITED2	226	Q99967
LRTALDDTVLQVMEM	CHSY3	491	Q70JA7
ILSMVIVLIMEVTAA	TSPAN16	91	Q9UKR8
RLMDENMDVIIFILL	TLR8	966	Q9NR97
GAQIIDLMMLVIDVT	EEFSEC	106	P57772
VMVLVEVTALGNLRM	RHD	141	Q02161
LLLIGMMITRAEQVD	TEP1	706	Q99973
MSIEIESSDVIRLIM	SMU1	1	Q2TAY7
LERRVTDIIMQKMTI	KIF21A	926	Q7Z4S6
ELLDLLQDMVVMLLS	RYR3	3866	Q15413
MLEEQLVRMLTREVM	XPO5	956	Q9HAV4
LVRMLTREVMDLITV	XPO5	961	Q9HAV4
LLVLQLMAVLCERMS	TANGO6	641	Q9C0B7
LADRFERLVELVTMM	NF1	1201	P21359
DMRIKVMILEFLTVA	NUP188	911	Q5SRE5
MIMVILLLLVAIVVV	STX8	216	Q9UNK0
LLIIMAQIIVAIQMV	SLC35F6	181	Q8N357
IIENMAEIMLFSLDL	VN1R5	6	Q7Z5H4
NMEQVVMIPSLLRDV	THRSP	26	Q92748
LEVVMKTERAMLIEA	TRRAP	1536	Q9Y4A5
TLDTMLTRILMVREV	ZMYM4	1516	Q5VZL5
IEVIDQRLIEARRMM	YEATS2	61	Q9ULM3
FEIVTMLLATMILVD	ART3	6	Q13508
IMLVQRQMSVIEEDL	NECAB1	251	Q8N987