Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunction6-phosphofructokinase activity

PFKM PFKP

2.57e-063192GO:0003872
GeneOntologyMolecularFunctionfructose-6-phosphate binding

PFKM PFKP

8.56e-065192GO:0070095
GeneOntologyMolecularFunctionphosphofructokinase activity

PFKM PFKP

1.80e-057192GO:0008443
GeneOntologyMolecularFunctionAMP binding

PFKM PFKP

1.78e-0421192GO:0016208
GeneOntologyMolecularFunctioncarbohydrate kinase activity

PFKM PFKP

1.78e-0421192GO:0019200
GeneOntologyBiologicalProcessfructose 1,6-bisphosphate metabolic process

PFKM PFKP

2.88e-059192GO:0030388
GeneOntologyBiologicalProcessfructose 6-phosphate metabolic process

PFKM PFKP

9.57e-0516192GO:0006002
GeneOntologyBiologicalProcesscanonical glycolysis

PFKM PFKP

1.67e-0421192GO:0061621
GeneOntologyBiologicalProcessNADH regeneration

PFKM PFKP

1.67e-0421192GO:0006735
GeneOntologyBiologicalProcessglucose catabolic process to pyruvate

PFKM PFKP

1.67e-0421192GO:0061718
GeneOntologyBiologicalProcessglycolytic process through glucose-6-phosphate

PFKM PFKP

2.38e-0425192GO:0061620
GeneOntologyBiologicalProcessNAD catabolic process

PFKM PFKP

2.38e-0425192GO:0019677
GeneOntologyBiologicalProcessglycolytic process through fructose-6-phosphate

PFKM PFKP

3.68e-0431192GO:0061615
GeneOntologyBiologicalProcessglucose catabolic process

PFKM PFKP

3.92e-0432192GO:0006007
GeneOntologyCellularComponent6-phosphofructokinase complex

PFKM PFKP

2.35e-063192GO:0005945
HumanPhenoFused cervical vertebrae

CHD4 NOG

4.53e-043552HP:0002949
HumanPhenoVertebral fusion

CHD4 NOG

2.02e-037452HP:0002948
DomainATP_PFK

PFKM PFKP

2.94e-063192IPR022953
DomainPHOSPHOFRUCTOKINASE

PFKM PFKP

2.94e-063192PS00433
DomainPFK

PFKM PFKP

2.94e-063192PF00365
Domain6-Pfructokinase_euk

PFKM PFKP

2.94e-063192IPR009161
DomainPhosphofructokinase_dom

PFKM PFKP

2.94e-063192IPR000023
DomainPhosphofructokinase_CS

PFKM PFKP

2.94e-063192IPR015912
DomainANK

POTEB AGAP11 POTEB2

1.98e-03251193SM00248
DomainANK_REPEAT

POTEB AGAP11 POTEB2

2.03e-03253193PS50088
DomainAnkyrin_rpt-contain_dom

POTEB AGAP11 POTEB2

2.05e-03254193IPR020683
DomainANK_REP_REGION

POTEB AGAP11 POTEB2

2.05e-03254193PS50297
DomainAnkyrin_rpt

POTEB AGAP11 POTEB2

2.24e-03262193IPR002110
DomainFN3

CRLF2 MYBPC1

1.49e-02185192SM00060
DomainFN3

CRLF2 MYBPC1

1.71e-02199192PS50853
PathwayBIOCARTA_PTDINS_PATHWAY

PFKM PFKP

1.39e-0423112M8809
PathwayKEGG_MEDICUS_REFERENCE_GLYCOLYSIS

PFKM PFKP

1.64e-0425112M47623
PathwayKEGG_GALACTOSE_METABOLISM

PFKM PFKP

1.78e-0426112M4377
PathwayKEGG_PENTOSE_PHOSPHATE_PATHWAY

PFKM PFKP

1.92e-0427112M1386
PathwayKEGG_FRUCTOSE_AND_MANNOSE_METABOLISM

PFKM PFKP

3.06e-0434112M15898
PathwayWP_GLYCOLYSIS_AND_GLUCONEOGENESIS

PFKM PFKP

5.38e-0445112M39474
PathwayWP_GLYCOLYSIS_AND_GLUCONEOGENESIS

PFKM PFKP

6.91e-0451112MM15928
PathwayKEGG_GLYCOLYSIS_GLUCONEOGENESIS

PFKM PFKP

1.02e-0362112M11521
PathwayREACTOME_GLUCOSE_METABOLISM

PFKM PFKP

1.78e-0382112MM15394
PathwayREACTOME_GLUCOSE_METABOLISM

PFKM PFKP

1.91e-0385112M1870
PathwayWP_CLEAR_CELL_RENAL_CELL_CARCINOMA_PATHWAYS

PFKM PFKP

1.95e-0386112M39375
PathwayWP_METABOLIC_EPILEPTIC_DISORDERS

PFKM PFKP

2.18e-0391112M48079
PathwayREACTOME_ADIPOGENESIS

MED14 CHD4

3.17e-03110112M48259
Pubmed

Cloning of human muscle phosphofructokinase cDNA.

PFKM PFKP

2.83e-0721922822475
Pubmed

Chimeric phosphofructokinases involving exchange of the N- and C-terminal halves of mammalian isozymes: implications for ligand binding sites.

PFKM PFKP

2.83e-07219217544406
Pubmed

Structures of human phosphofructokinase-1 and atomic basis of cancer-associated mutations.

PFKM PFKP

2.83e-07219225985179
Pubmed

Genomic organization, 5'flanking region and tissue-specific expression of mouse phosphofructokinase C gene.

PFKM PFKP

8.48e-07319211137296
Pubmed

Biochemical and transcript level differences between the three human phosphofructokinases show optimisation of each isoform for specific metabolic niches.

PFKM PFKP

8.48e-07319233141153
Pubmed

Phosphofructokinase (PFK) isozymes in man. I. Studies of adult human tissues.

PFKM PFKP

8.48e-073192156693
Pubmed

Functional expression of human mutant phosphofructokinase in yeast: genetic defects in French Canadian and Swiss patients with phosphofructokinase deficiency.

PFKM PFKP

8.48e-0731927825568
Pubmed

Isozymes of human phosphofructokinase in blood cells and cultured cell lines: molecular and genetic evidence for a trigenic system.

PFKM PFKP

8.48e-0731926451249
Pubmed

Characterization of the enzymatic defect in late-onset muscle phosphofructokinase deficiency. New subtype of glycogen storage disease type VII.

PFKM PFKP

8.48e-0731922960695
Pubmed

Isozymes of human phosphofructokinase: identification and subunit structural characterization of a new system.

PFKM PFKP

8.48e-0731926444721
Pubmed

Phosphofructokinase isozyme expression during myoblast differentiation.

PFKM PFKP

8.48e-0731922521854
Pubmed

Direct control of regulatory T cells by keratinocytes.

CRLF2 CHD4

2.82e-06519228092372
Pubmed

Stabilization of phosphofructokinase 1 platelet isoform by AKT promotes tumorigenesis.

PFKM PFKP

4.24e-06619229038421
Pubmed

Two novel transcripts encoding two Ankyrin repeat containing proteins have preponderant expression during the mouse spermatogenesis.

POTEB POTEB2

4.24e-06619217171436
Pubmed

POTE, a highly homologous gene family located on numerous chromosomes and expressed in prostate, ovary, testis, placenta, and prostate cancer.

POTEB POTEB2

7.90e-06819212475935
Pubmed

LRF maintains genome integrity by regulating the non-homologous end joining pathway of DNA repair.

CHD4 PFKM PFKP

1.06e-057919326446488
Pubmed

Rewiring of embryonic glucose metabolism via suppression of PFK-1 and aldolase during mouse chorioallantoic branching.

PFKM PFKP

4.30e-051819228049690
Pubmed

TRIP12 promotes small-molecule-induced degradation through K29/K48-branched ubiquitin chains.

MED14 CHD4

1.48e-043319233567268
Pubmed

A long non-coding RNA specifically expressed in early embryos programs the metabolic balance in adult mice.

PFKM PFKP

2.07e-043919233059001
Pubmed

Proteomic identification of brain proteins that interact with dynein light chain LC8.

PFKM PFKP

2.40e-044219214760703
Pubmed

Progesterone induced Warburg effect in HEK293 cells is associated with post-translational modifications and proteasomal degradation of progesterone receptor membrane component 1.

PFKM PFKP

4.59e-045819231067491
CytobandEnsembl 112 genes in cytogenetic band chrXp22

ACE2 CRLF2 KLHL15

1.45e-04250193chrXp22
Cytoband15q11.2

POTEB POTEB2

2.29e-0317219215q11.2
CytobandEnsembl 112 genes in cytogenetic band chr15q11

POTEB POTEB2

3.61e-03217192chr15q11
GeneFamilyAnkyrin repeat domain containing|POTE ankyrin domain containing

POTEB POTEB2

4.98e-0513152685
GeneFamilyAnkyrin repeat domain containing

POTEB AGAP11 POTEB2

9.57e-04242153403
GeneFamilyFibronectin type III domain containing

CRLF2 MYBPC1

7.58e-03160152555
CoexpressionGSE17974_IL4_AND_ANTI_IL12_VS_UNTREATED_6H_ACT_CD4_TCELL_DN

SLC35F2 KLHL15 NOG PFKM

1.08e-05196194M4218
ToppCellTCGA-Head_and_Esophagus-Primary_Tumor-Head_and_Neck_Carcinoma-Squamous_Cell_Carcinoma_-_Basaloid_Type|TCGA-Head_and_Esophagus / Sample_Type by Project: Shred V9

POTEB TAS2R1 GPR151

1.34e-05110193f26c7d02e8931e91065deea2f3f51d452bc445da
ComputationalGlycolysis and TCA cycle.

PFKM PFKP

1.56e-042682MODULE_306
ComputationalGenes in the cancer module 97.

MED14 KLHL15

2.22e-039882MODULE_97
ComputationalGenes in the cancer module 182.

MED14 KLHL15

2.31e-0310082MODULE_182
ComputationalGenes in the cancer module 262.

MED14 KLHL15

2.31e-0310082MODULE_261
DrugUridine diphosphate 2-deoxyglucose

PFKM PFKP

3.54e-064182CID000165519
DrugAC1MIX9B

PFKM PFKP

8.84e-066182CID003081623
Drugdactylarin

PFKM PFKP

1.24e-057182CID000161389
Drugglipentide

PFKM PFKP

1.24e-057182CID000065779
Drugphenylthiocarbamide

MED14 PFKM PFKP

2.81e-0576183CID000676454
Drugfructose 2-phosphorothioate 6-phosphate

PFKM PFKP

3.23e-0511182CID000195184
DrugC14:1n-5

PFKM PFKP

3.23e-0511182CID000068344
DrugM 16209

PFKM PFKP

6.16e-0515182CID000164260
Drugdibenzyl succinate

PFKM PFKP

7.04e-0516182CID000007653
DrugAC1L1AO2

PFKM PFKP

8.96e-0518182CID000001073
DrugBRL 26830A

PFKM PFKP

1.00e-0419182CID006438331
Drugd-sedoheptulose 1,7-diphosphate

PFKM PFKP

1.35e-0422182CID000001193
DrugOrphenadrine

ACE2 CRLF2 SLC35F2 PFKM

2.10e-04388184ctd:D009966
Drugtetrahydroaldosterone-3-glucuronide

NOG PFKM

2.37e-0429182CID000167918
Drug1-o-phosphonohex-2-ulose

PFKM PFKP

2.37e-0429182CID000000481
Drugbeta-guanidinopropionic acid

MYBPC1 PFKM

2.53e-0430182CID000067701
Drug2,5-anhydro-D-mannitol

PFKM PFKP

2.71e-0431182CID000001494
DrugTenax

PFKM PFKP

3.07e-0433182CID000122082
Drugphosphonate analog

PFKM PFKP

3.07e-0433182CID000475766
Diseaseglycogen storage disease (implicated_via_orthology)

PFKM PFKP

1.87e-064172DOID:2747 (implicated_via_orthology)
Diseasedisease of metabolism (implicated_via_orthology)

PFKM PFKP

6.52e-0521172DOID:0014667 (implicated_via_orthology)
Diseaselip morphology measurement

GPR151 NOG

5.21e-03189172EFO_0007845
Diseaseeye morphology measurement

NOG PFKP

6.87e-03218172EFO_0007858

Protein segments in the cluster

PeptideGeneStartEntry
GMLLKRSGKWLKTWK

AGAP11

126

Q8TF27
LKKWRMKRESLLEWG

ABCA6

21

Q8N139
WWGKVPRKDLIVMLR

POTEB2

111

H3BUK9
WWLKLRPILKILAKY

PFKM

741

P08237
PKEQWWLKLRPLMKI

PFKP

746

Q01813
NMWKLRPLLKKWLKE

POU5F2

176

Q8N7G0
LWKLWRVKKFLIPSV

CRLF2

251

Q9HC73
GLKGVWKWMITKKPP

GPR151

316

Q8TDV0
MKRIIPWIQQLKFWL

MED14

486

O60244
SKILLLKKPRVWWEL

KLHL15

296

Q96M94
LEKWRWMVFKGEIPK

ACE2

456

Q9BYF1
PALKGKVQKILIWKW

CHD4

496

Q14839
MWKLLLWVGLVLVLK

OVGP1

1

Q12889
LLPLTWLSKKHMIWI

MT-ND4

11

P03905
RLSKKLRRKLQMWLW

NOG

136

Q13253
WKLVNKKWMLTLLRI

CWH43

61

Q9H720
WWGKVPRKDLIVMLR

POTEB

111

A0A0A6YYL3
LVILKRKWWKYILLG

SLC35F2

101

Q8IXU6
IWLKMRISKLVPWMI

TAS2R1

116

Q9NYW7
LLKKKILGRVWWLMP

PRO2829

6

Q9P1C3
LLRKPTIKWFKGKWM

MYBPC1

86

Q00872