Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyCellularComponent	dendritic spine	RHOA ITGA8 ATP1A3 ARHGAP44	4.88e-04	242	32	4	GO:0043197
GeneOntologyCellularComponent	neuron spine	RHOA ITGA8 ATP1A3 ARHGAP44	5.27e-04	247	32	4	GO:0044309
Pathway	WP_WNT_SIGNALING_WP428	VANGL2 RHOA FZD8 PPP3CB	2.56e-05	113	22	4	M39669
Pathway	REACTOME_BETA_CATENIN_INDEPENDENT_WNT_SIGNALING	VANGL2 RHOA FZD8 PPP3CB	6.99e-05	146	22	4	M27288
Pathway	KEGG_WNT_SIGNALING_PATHWAY	VANGL2 RHOA FZD8 PPP3CB	7.96e-05	151	22	4	M19428
Pathway	REACTOME_P75NTR_REGULATES_AXONOGENESIS	RHOA MCF2	8.31e-05	9	22	2	MM14745
Pathway	REACTOME_P75NTR_REGULATES_AXONOGENESIS	RHOA MCF2	1.04e-04	10	22	2	M27073
Pathway	REACTOME_PCP_CE_PATHWAY	VANGL2 RHOA FZD8	3.79e-04	92	22	3	M27322
Pathway	REACTOME_RHO_GTPASE_CYCLE	VANGL2 RHOA MCF2 TOR1AIP1 ARHGAP44	4.86e-04	439	22	5	MM15595
Pathway	REACTOME_RHO_GTPASE_CYCLE	VANGL2 RHOA MCF2 TOR1AIP1 ARHGAP44	5.44e-04	450	22	5	M27078
Pathway	KEGG_MEDICUS_REFERENCE_ITGA_B_RHOGAP_RHOA_SIGNALING_PATHWAY	RHOA ITGA8	5.77e-04	23	22	2	M47537
Pathway	KEGG_MEDICUS_REFERENCE_ITGA_B_RHOGEF_RHOA_SIGNALING_PATHWAY	RHOA ITGA8	5.77e-04	23	22	2	M47720
Pathway	WP_PHYSIOLOGICAL_AND_PATHOLOGICAL_HYPERTROPHY_OF_THE_HEART	RHOA PPP3CB	6.28e-04	24	22	2	M39576
Pathway	WP_WNT_SIGNALING_PATHWAY	VANGL2 RHOA FZD8	6.39e-04	110	22	3	MM15977
Pathway	REACTOME_BETA_CATENIN_INDEPENDENT_WNT_SIGNALING	RHOA FZD8 PPP3CB	8.84e-04	123	22	3	MM14988
Pubmed	Expression Profiles of ITGA8 and VANGL2 Are Altered in Congenital Anomalies of the Kidney and Urinary Tract (CAKUT).	VANGL2 ITGA8	8.20e-07	2	32	2	39064873
Pubmed	Vangl2/RhoA Signaling Pathway Regulates Stem Cell Self-Renewal Programs and Growth in Rhabdomyosarcoma.	VANGL2 RHOA	8.20e-07	2	32	2	29499154
Pubmed	Identification of Rho GTPase-dependent sites in the Dbl homology domain of oncogenic Dbl that are required for transformation.	RHOA MCF2	2.46e-06	3	32	2	10854437
Pubmed	Phosphoinositide 3-kinase C2β regulates RhoA and the actin cytoskeleton through an interaction with Dbl.	RHOA MCF2	2.46e-06	3	32	2	22984590
Pubmed	Integrin alpha8beta1 regulates adhesion, migration and proliferation of human intestinal crypt cells via a predominant RhoA/ROCK-dependent mechanism.	RHOA ITGA8	2.46e-06	3	32	2	19527220
Pubmed	The Down syndrome critical region protein TTC3 inhibits neuronal differentiation via RhoA and Citron kinase.	RHOA TTC3	2.46e-06	3	32	2	17488780
Pubmed	Rho-GTPase-activating protein interacting with Cdc-42-interacting protein 4 homolog 2 (Rich2): a new Ras-related C3 botulinum toxin substrate 1 (Rac1) GTPase-activating protein that controls dendritic spine morphogenesis.	RHOA ARHGAP44	4.92e-06	4	32	2	24352656
Pubmed	Overexpressions of RHOA, CSNK1A1, DVL2, FZD8, and LRP5 genes enhance gastric cancer development in the presence of Helicobacter pylori.	RHOA FZD8	8.19e-06	5	32	2	36720664
Pubmed	Vang-like protein 2 and Rac1 interact to regulate adherens junctions.	VANGL2 RHOA	1.23e-05	6	32	2	20067994
Pubmed	MAGI-3 is involved in the regulation of the JNK signaling pathway as a scaffold protein for frizzled and Ltap.	VANGL2 FZD8	1.72e-05	7	32	2	15195140
Pubmed	Scribble1 plays an important role in the pathogenesis of neural tube defects through its mediating effect of Par-3 and Vangl1/2 localization.	VANGL2 LLGL2	1.72e-05	7	32	2	28369449
Pubmed	A core cochlear phenotype in USH1 mouse mutants implicates fibrous links of the hair bundle in its cohesion, orientation and differential growth.	VANGL2 USH1G	2.94e-05	9	32	2	18339676
Pubmed	Vangl2 acts via RhoA signaling to regulate polarized cell movements during development of the proximal outflow tract.	VANGL2 RHOA	3.67e-05	10	32	2	15637299
Pubmed	Cytoplasmic localization of GRHL3 upon epidermal differentiation triggers cell shape change for epithelial morphogenesis.	VANGL2 RHOA	3.67e-05	10	32	2	30283008
Pubmed	Non-canonical Wnt signaling regulates cell polarity in female reproductive tract development via van gogh-like 2.	VANGL2 RHOA	3.67e-05	10	32	2	19363157
Pubmed	Null and hypomorph Prickle1 alleles in mice phenocopy human Robinow syndrome and disrupt signaling downstream of Wnt5a.	VANGL2 RHOA	4.49e-05	11	32	2	25190059
Pubmed	Enlarged dendritic spines and pronounced neophobia in mice lacking the PSD protein RICH2.	RHOA ARHGAP44	5.38e-05	12	32	2	26969129
Pubmed	Convergent extension, planar-cell-polarity signalling and initiation of mouse neural tube closure.	VANGL2 RHOA	6.36e-05	13	32	2	17229766
Pubmed	The Meckel-Gruber syndrome protein TMEM67 controls basal body positioning and epithelial branching morphogenesis in mice via the non-canonical Wnt pathway.	VANGL2 RHOA	8.55e-05	15	32	2	26035863
Pubmed	Prickle1 mutation causes planar cell polarity and directional cell migration defects associated with cardiac outflow tract anomalies and other structural birth defects.	VANGL2 RHOA	8.55e-05	15	32	2	26883626
Pubmed	The non-canonical Wnt-PCP pathway shapes the mouse caudal neural plate.	VANGL2 RHOA	8.55e-05	15	32	2	29636380
Pubmed	The Role of Sorting Nexin 17 in Cardiac Development.	VANGL2 RHOA	1.39e-04	19	32	2	34988124
Pubmed	SHROOM3 is downstream of the planar cell polarity pathway and loss-of-function results in congenital heart defects.	VANGL2 RHOA	1.54e-04	20	32	2	32511952
Pubmed	Nuclear localization of Prickle2 is required to establish cell polarity during early mouse embryogenesis.	VANGL2 RHOA	2.24e-04	24	32	2	22333836
Pubmed	Alterations in the brain interactome of the intrinsically disordered N-terminal domain of the cellular prion protein (PrPC) in Alzheimer's disease.	RHOA PPP3CB ATP1A3 SH3KBP1	2.63e-04	341	32	4	29791485
Pubmed	Recent acquisition of imprinting at the rodent Sfmbt2 locus correlates with insertion of a large block of miRNAs.	ITGA8 PTER	2.84e-04	27	32	2	21510876
Pubmed	Scribble is required for normal epithelial cell-cell contacts and lumen morphogenesis in the mammalian lung.	VANGL2 RHOA	3.05e-04	28	32	2	23195221
Pubmed	Regulation of retinal progenitor expansion by Frizzled receptors: implications for microphthalmia and retinal coloboma.	RHOA FZD8	3.75e-04	31	32	2	22228100
Pubmed	A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.	ASCC2 TRIR TTC3 DYSF CLUH	4.87e-04	724	32	5	36232890
Pubmed	Systematic analysis of human protein complexes identifies chromosome segregation proteins.	RHOA LLGL2 CLP1 GPKOW TOR1AIP1 SH3KBP1	5.72e-04	1155	32	6	20360068
Pubmed	Malformation of Tear Ducts Underlies the Epiphora and Precocious Eyelid Opening in Prickle 1 Mutant Mice: Genetic Implications for Tear Duct Genesis.	VANGL2 FZD8	8.64e-04	47	32	2	33141892
Pubmed	Activin A Determines Steroid Levels and Composition in the Fetal Testis.	ITGA8 SH3KBP1	8.64e-04	47	32	2	32274496
Cytoband	Ensembl 112 genes in cytogenetic band chr10p13	ITGA8 PTER	9.82e-04	66	32	2	chr10p13
Cytoband	Ensembl 112 genes in cytogenetic band chr17q25	ENPP7 LLGL2 USH1G	1.27e-03	307	32	3	chr17q25
Cytoband	17q25.1	LLGL2 USH1G	1.47e-03	81	32	2	17q25.1
ToppCell	Cerebellum-Neuronal\|Cerebellum / BrainAtlas - Mouse McCarroll V32	PPP3CB ATP1A3 TTC3 CDH12 ARHGAP44	2.16e-07	187	32	5	61b9d6eb131a674598aa8409d7fa909c8765442d
ToppCell	LPS-IL1RA-Epithelial_alveolar-AT_1-Differentiating_AT2\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	LLGL2 PTER NAALADL2 ARHGAP44	9.29e-06	186	32	4	4e94158db52df41d71e67b02b9895a358eebee0f
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-24m-Neuronal-neuron\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ATP1A3 TTC3 CDH12 ARHGAP44	9.69e-06	188	32	4	1efbc99bcd6542e5d9fa91edb7c4295167914786
ToppCell	Striatum-Neuronal\|Striatum / BrainAtlas - Mouse McCarroll V32	PPP3CB ATP1A3 TTC3 ARHGAP44	1.24e-05	200	32	4	c888fd487990cad482a4ca47601cdebc0ca3f3ce
ToppCell	Tracheal-NucSeq-Epithelial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	LLGL2 GALNT7 NAALADL2 CDH12	1.24e-05	200	32	4	d3af0a706baf66e3f32e67b17dcfc31e5b32ce0e
Disease	response to heparin, antibody measurement	VANGL2 NAALADL2	1.88e-04	20	30	2	EFO_0004556, EFO_0006816
Disease	serum IgA measurement	ASCC2 DYSF	4.56e-04	31	30	2	EFO_0004912
Disease	facial morphology	ITGA8 ACTRT2	1.44e-03	55	30	2	EFO_0004743
Disease	neonatal abstinence syndrome	ACTRT2 CDH12	2.79e-03	77	30	2	EFO_0005799
Disease	serum albumin measurement	RHOA BBX DYSF SH3KBP1	2.90e-03	592	30	4	EFO_0004535
Disease	feeling miserable measurement	BBX CLUH	2.93e-03	79	30	2	EFO_0009598
Disease	asthma exacerbation measurement	NAALADL2 CDH12	4.04e-03	93	30	2	EFO_0007614
Disease	economic and social preference	CDH12 ARHGAP44	4.38e-03	97	30	2	EFO_0004827

Protein segments in the cluster

Peptide	Gene	Start	Entry
RRQAMERPPALEDTE	USH1G	446	Q495M9
EEQKNPREVMDPREA	VANGL2	376	Q9ULK5
EDDESPEQRARRPMN	BBX	71	Q8WY36
EPSLNPRENREKMAE	ACTRT2	111	Q8TDY3
QLDRNLDREMKPDPT	ASCC2	516	Q9H1I8
VEDLAKMNLENRPPR	OTUD6A	76	Q7L8S5
THVNMEREQKPPERR	NXF3	86	Q9H4D5
EREQKPPERRMEGNM	NXF3	91	Q9H4D5
PAERRMDEPVRAEQA	LLGL2	751	Q6P1M3
SRMPRPDEEQEKDKE	GPKOW	221	Q92917
MRPERQPQTREQDRA	CRNN	206	Q9UBG3
RARPPQEDMTDREQL	ITGA8	1041	P53708
GPDIDMPDDNKRIRR	PTER	266	Q96BW5
DRMRCDRLPEQGNPD	FZD8	131	Q9H461
SPLSRMREDRDVNDP	GALNT7	36	Q86SF2
ENEEENRPLMRPVSE	MCF2	906	P10911
AAESDIMKRQPRNPR	ATP1A3	816	P13637
PRQRPPMEDNTDIRD	CDH12	701	P55289
GPESPERREMVRQVD	ENPP7	206	Q6UWV6
DRINERMPPRKDAVQ	PPP3CB	486	P16298
RDEPNMNPKLEDPRR	DYSF	2006	O75923
QEPVKPEEGRDMANR	RHOA	136	P61586
RQSRMPQEDERPADE	SHD	166	Q96IW2
MLPNRTEEKERPERE	SH3KBP1	371	Q96B97
DMDPADRRQPEQARR	ARHGAP44	476	Q17R89
EQMRRQAEKEEERGP	CLP1	101	Q92989
RNRDRAEEPMATEPA	CLUH	1271	O75153
EMPLQDPRSREEAAR	UQCC3	41	Q6UW78
RRQPRPQETEEMKTR	TOR1AIP1	111	Q5JTV8
ERMEEDLRESNPPKN	TTC3	786	P53804
EEDSNMKREQPRERP	USP18	31	Q9UMW8
RKMEEEQRQRQEEPP	TRIR	71	Q9BQ61
FQSDEMRPANDPKER	NAALADL2	686	Q58DX5