Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionmethyl-CpG binding

MBD3L5 MBD3L3 MBD3L4 MBD2 MBD3L2 MBD3L2B

1.45e-1231256GO:0008327
GeneOntologyBiologicalProcessDNA methylation-dependent constitutive heterochromatin formation

MBD3L5 MBD3L3 MBD3L4 MBD2 MBD3L2 MBD3L2B

1.14e-1144256GO:0006346
GeneOntologyBiologicalProcessfacultative heterochromatin formation

MBD3L5 MBD3L3 MBD3L4 MBD2 MBD3L2 MBD3L2B

4.62e-1155256GO:0140718
GeneOntologyBiologicalProcessheterochromatin formation

MBD3L5 MBD3L3 MBD3L4 MBD2 MBD3L2 MBD3L2B

3.47e-08163256GO:0031507
GeneOntologyBiologicalProcessnegative regulation of gene expression, epigenetic

MBD3L5 MBD3L3 MBD3L4 MBD2 MBD3L2 MBD3L2B

1.28e-07203256GO:0045814
GeneOntologyBiologicalProcessepigenetic regulation of gene expression

MBD3L5 MBD3L3 MBD3L4 MBD2 MBD3L2 MBD3L2B

2.20e-06330256GO:0040029
GeneOntologyBiologicalProcessnegative regulation of transcription by RNA polymerase II

MBD3L5 MBD3L3 MBD3L4 FGFR2 BARX2 MBD2 MBD3L2 MBD3L2B

2.23e-051053258GO:0000122
GeneOntologyBiologicalProcessnegative regulation of DNA-templated transcription

MBD3L5 MBD3L3 MBD3L4 FGFR2 BARX2 MBD2 MBD3L2 MBD3L2B

1.67e-041399258GO:0045892
GeneOntologyBiologicalProcessnegative regulation of RNA biosynthetic process

MBD3L5 MBD3L3 MBD3L4 FGFR2 BARX2 MBD2 MBD3L2 MBD3L2B

1.79e-041413258GO:1902679
GeneOntologyBiologicalProcesschromatin remodeling

MBD3L5 MBD3L3 MBD3L4 MBD2 MBD3L2 MBD3L2B

2.08e-04741256GO:0006338
GeneOntologyBiologicalProcesschromatin organization

MBD3L5 MBD3L3 MBD3L4 MBD2 MBD3L2 MBD3L2B

5.75e-04896256GO:0006325
GeneOntologyCellularComponenttranscription regulator complex

ETS1 BARX2 SNAPC4 MBD2 RFXAP

6.13e-04596255GO:0005667
DomainMBD2/MBD3_p55-bd

MBD3L5 MBD3L3 MBD3L4 MBD2 MBD3L2

4.71e-147245IPR032343
DomainMeCpG-bd_2/3_C_dom

MBD3L5 MBD3L3 MBD3L4 MBD2 MBD3L2

4.71e-147245IPR025884
DomainMBD_C

MBD3L5 MBD3L3 MBD3L4 MBD2 MBD3L2

4.71e-147245PF14048
DomainMBDa

MBD3L5 MBD3L3 MBD3L4 MBD2 MBD3L2

4.71e-147245PF16564
Pubmed

MBD3L2 interacts with MBD3 and components of the NuRD complex and can oppose MBD2-MeCP1-mediated methylation silencing.

MBD3L5 MBD3L3 MBD3L4 MBD2 MBD3L2 MBD3L2B

3.59e-161525615701600
Pubmed

Haploid male germ cell- and oocyte-specific Mbd3l1 and Mbd3l2 genes are dispensable for early development, fertility, and zygotic DNA demethylation in the mouse.

MBD3L5 MBD3L3 MBD3L4 MBD3L2 MBD3L2B

7.52e-16625518942147
Pubmed

MBD3L1 and MBD3L2, two new proteins homologous to the methyl-CpG-binding proteins MBD2 and MBD3: characterization of MBD3L1 as a testis-specific transcriptional repressor.

MBD3L5 MBD3L3 MBD3L4 MBD3L2 MBD3L2B

7.52e-16625512504854
Pubmed

Unique features of the anti-parallel, heterodimeric coiled-coil interaction between methyl-cytosine binding domain 2 (MBD2) homologues and GATA zinc finger domain containing 2A (GATAD2A/p66α).

MBD2 MBD3L2

4.95e-06525223239876
Pubmed

Differential regulation of MAGE-A1 promoter activity by BORIS and Sp1, both interacting with the TATA binding protein.

ETS1 MBD2

1.04e-05725225363021
Cytoband19p13.2

MBD3L5 MBD3L3 MBD3L4 MBD3L2 MBD3L2B

1.45e-0722925519p13.2
CytobandEnsembl 112 genes in cytogenetic band chr19p13

MBD3L5 MBD3L3 MBD3L4 MBD3L2 MBD3L2B

6.20e-05797255chr19p13
CytobandEnsembl 112 genes in cytogenetic band chr11q24

ETS1 BARX2 OR4D5

1.52e-04191253chr11q24
CytobandEnsembl 112 genes in cytogenetic band chr9q34

SNAPC4 VAV2

1.35e-02325252chr9q34
GeneFamilyBlood group antigens|CD molecules|I-set domain containing|Immunoglobulin like domain containing

MYBPH FGFR2

6.68e-03161142593
ToppCellControl_saline-Epithelial_alveolar-AT_1-Differentiating_AT2|Control_saline / Treatment groups by lineage, cell group, cell type

FGFR2 SNAPC4 ELMOD2 FAM221A

4.46e-06200254eac33be484dc443794e66e473f03e98406c2983e
DiseaseVaricose veins

ETS1 AGGF1 MOB2

3.36e-04193213HP_0002619
Diseaseadverse effect, response to xenobiotic stimulus

ETS1 CTNNA3

8.05e-0459212EFO_0009658, GO_0009410
DiseasePROSTATE CANCER, HEREDITARY, 1

MBD2 MOB2

8.33e-0460212C4722327
DiseaseProstate cancer, familial

MBD2 MOB2

1.10e-0369212C2931456
Diseaseallergic disease, age at onset

ETS1 MBD2

1.16e-0371212EFO_0004847, MONDO_0005271
Diseaseulcerative colitis

ETS1 SNAPC4 CTNNA3

1.66e-03335213EFO_0000729
DiseaseReperfusion Injury

ETS1 ADORA2B

1.82e-0389212C0035126
Diseaseprostate carcinoma

FGFR2 BARX2 MBD2 MOB2

3.28e-03891214EFO_0001663

Protein segments in the cluster

PeptideGeneStartEntry
PKNRWGKMMEKKREQ

C2orf49

66

Q9BVC5
LMKLWNLLMPTKKLN

ELMOD2

131

Q8IZ81
PAQGKNKPKWAMNMA

ADORA2B

261

P29275
WHLKMPKIKMPKISM

AHNAK

3146

Q09666
NKGRKMLEKMGWKKG

AGGF1

621

Q8N302
MDWLMGKSKAKPNGK

MOB2

1

Q70IA6
MPTMRWLKNGKEFKQ

FGFR2

186

P21802
GKLKRNMMPWALQKK

MBD3L5

16

A6NJ08
VARRWGKRKNKPKMN

ETS1

371

P14921
GKLKRNMMPWALQKK

MBD3L2B

16

A0A1B0GVZ6
GKLKRNMMPWALQKK

MBD3L3

16

A6NE82
GKMMPSKLQKNKQRL

MBD2

211

Q9UBB5
VMWRMKAPAKKPLIK

CTNNA3

846

Q9UI47
MKWKKMVLKGGQEAP

BARX2

186

Q9UMQ3
KKLPEKLRIGWNNKM

GCNA

536

Q96QF7
RMKMEKAAKWKGKAP

FAM221A

276

A4D161
PRWLMMKGKVKEAKQ

SLC22A14

321

Q9Y267
GKLKRNMMPWALQKK

MBD3L4

16

A6NDZ8
MAMKKLWRRKKDPIG

OR4D5

296

Q8NGN0
GKLKRNMMPWALQKK

MBD3L2

16

Q8NHZ7
GMPMRKVRSKSWKKL

PLCD4

21

Q9BRC7
RASPKPKIIWMKNKM

MYBPH

406

Q13203
PKIIWMKNKMEIQGN

MYBPH

411

Q13203
QRKPWMCKKHRNKMY

RFXAP

156

O00287
CLSKWKIMMGKKQGL

SNAPC4

491

Q5SXM2
PMNNKDVKKSHGKMW

VAV2

461

P52735