Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionG protein-coupled receptor activity

OPN1MW2 OR8H2 OR6F1 OR7D4 OR6B1 OPN1MW3 OR4M2 OR6V1 OR7C2 OR1J1 F2RL3 OR11H7 OR6C4 OR4M1 OR1D5 OPN1LW OR1E3 OR1G1 OR52E5 OR1F2P OPN1MW OR51G1 OR7A17 OR11H12 ADGRE1 OR1D4 OR7A2P OR1J4 OR4M2B FFAR4 OR1D2

1.13e-228847531GO:0004930
GeneOntologyMolecularFunctionolfactory receptor activity

OR8H2 OR6F1 OR7D4 OR6B1 OR4M2 OR6V1 OR7C2 OR1J1 OR11H7 OR6C4 OR4M1 OR1D5 OR1E3 OR1G1 OR52E5 OR1F2P OR51G1 OR7A17 OR11H12 OR1D4 OR7A2P OR1J4 OR4M2B OR1D2

5.19e-224317524GO:0004984
GeneOntologyMolecularFunctiontransmembrane signaling receptor activity

OPN1MW2 OR8H2 OR6F1 OR7D4 OR6B1 OPN1MW3 OR4M2 ERBB2 OR6V1 OR7C2 OR1J1 F2RL3 OR11H7 OR6C4 OR4M1 OR1D5 OPN1LW OR1E3 OR1G1 OR52E5 OR1F2P OPN1MW OR51G1 OR7A17 CHRNA10 OR11H12 ADGRE1 OR1D4 OR7A2P OR1J4 OR4M2B FFAR4 OR1D2

2.29e-1913537533GO:0004888
GeneOntologyMolecularFunctionG protein-coupled photoreceptor activity

OPN1MW2 OPN1MW3 OPN1LW OPN1MW

2.43e-0715754GO:0008020
GeneOntologyMolecularFunctionphotoreceptor activity

OPN1MW2 OPN1MW3 OPN1LW OPN1MW

4.21e-0717754GO:0009881
GeneOntologyBiologicalProcessdetection of stimulus

OPN1MW2 OR8H2 OR6F1 OR7D4 OR6B1 OPN1MW3 OR4M2 OR6V1 OR7C2 OR1J1 OR11H7 OR6C4 OR4M1 OR1D5 OPN1LW OR1E3 OR1G1 OR52E5 OR1F2P OPN1MW OR51G1 OR7A17 CHRNA10 OR11H12 OR1D4 OR7A2P OR1J4 OR4M2B FFAR4 OR1D2

1.28e-247227430GO:0051606
GeneOntologyBiologicalProcessdetection of chemical stimulus involved in sensory perception

OR8H2 OR6F1 OR7D4 OR6B1 OR4M2 OR6V1 OR7C2 OR1J1 OR11H7 OR6C4 OR4M1 OR1D5 OR1E3 OR1G1 OR52E5 OR1F2P OR51G1 OR7A17 OR11H12 OR1D4 OR7A2P OR1J4 OR4M2B FFAR4 OR1D2

1.26e-224857425GO:0050907
GeneOntologyBiologicalProcessdetection of chemical stimulus involved in sensory perception of smell

OR8H2 OR6F1 OR7D4 OR6B1 OR4M2 OR6V1 OR7C2 OR1J1 OR11H7 OR6C4 OR4M1 OR1D5 OR1E3 OR1G1 OR52E5 OR1F2P OR51G1 OR7A17 OR11H12 OR1D4 OR7A2P OR1J4 OR4M2B OR1D2

1.80e-224327424GO:0050911
GeneOntologyBiologicalProcessdetection of stimulus involved in sensory perception

OR8H2 OR6F1 OR7D4 OR6B1 OR4M2 OR6V1 OR7C2 OR1J1 OR11H7 OR6C4 OR4M1 OR1D5 OR1E3 OR1G1 OR52E5 OR1F2P OR51G1 OR7A17 CHRNA10 OR11H12 OR1D4 OR7A2P OR1J4 OR4M2B FFAR4 OR1D2

5.56e-225827426GO:0050906
GeneOntologyBiologicalProcessdetection of chemical stimulus

OR8H2 OR6F1 OR7D4 OR6B1 OR4M2 OR6V1 OR7C2 OR1J1 OR11H7 OR6C4 OR4M1 OR1D5 OR1E3 OR1G1 OR52E5 OR1F2P OR51G1 OR7A17 OR11H12 OR1D4 OR7A2P OR1J4 OR4M2B FFAR4 OR1D2

8.31e-225247425GO:0009593
GeneOntologyBiologicalProcesssensory perception of smell

OR8H2 OR6F1 OR7D4 OR6B1 OR4M2 OR6V1 OR7C2 OR1J1 OR11H7 OR6C4 OR4M1 OR1D5 OR1E3 OR1G1 OR52E5 OR1F2P OR51G1 OR7A17 OR11H12 OR1D4 OR7A2P OR1J4 OR4M2B OR1D2

1.02e-214657424GO:0007608
GeneOntologyBiologicalProcesssensory perception of chemical stimulus

OR8H2 OR6F1 OR7D4 OR6B1 OR4M2 OR6V1 OR7C2 OR1J1 OR11H7 OR6C4 OR4M1 OR1D5 OR1E3 OR1G1 OR52E5 OR1F2P OR51G1 OR7A17 OR11H12 OR1D4 OR7A2P OR1J4 OR4M2B FFAR4 OR1D2

2.36e-215477425GO:0007606
GeneOntologyBiologicalProcesssensory perception

OPN1MW2 OR8H2 OR6F1 OR7D4 OR6B1 OPN1MW3 OR4M2 OR6V1 OR7C2 OR1J1 OR11H7 OR6C4 OR4M1 OR1D5 OPN1LW OR1E3 OR1G1 OR52E5 OR1F2P OPN1MW OR51G1 OR7A17 CHRNA10 OR11H12 OR1D4 OR7A2P OR1J4 OR4M2B FFAR4 OR1D2

1.04e-1910727430GO:0007600
GeneOntologyBiologicalProcessG protein-coupled receptor signaling pathway

OPN1MW2 OR8H2 OR6F1 OR7D4 OR6B1 OPN1MW3 OR4M2 ADCY4 OR6V1 OR7C2 OR1J1 F2RL3 OR11H7 OR6C4 OR4M1 OR1D5 OPN1LW OR1E3 OR1G1 OR52E5 OR1F2P OPN1MW OR51G1 OR7A17 OR11H12 ADGRE1 OR1D4 OR7A2P OR1J4 ADCY9 OR4M2B FFAR4 OR1D2

1.31e-1913957433GO:0007186
GeneOntologyBiologicalProcessphototransduction

OPN1MW2 OPN1MW3 OPN1LW OPN1MW

3.91e-0553744GO:0007602
GeneOntologyBiologicalProcessdetection of visible light

OPN1MW2 OPN1MW3 OPN1LW OPN1MW

5.22e-0557744GO:0009584
GeneOntologyBiologicalProcessadenylate cyclase-activating G protein-coupled receptor signaling pathway

OR4M2 ADCY4 OR4M1 ADGRE1 ADCY9 FFAR4

6.40e-05191746GO:0007189
GeneOntologyBiologicalProcesscellular response to light stimulus

OPN1MW2 OPN1MW3 OPN1LW CASP9 OPN1MW

1.05e-04130745GO:0071482
GeneOntologyBiologicalProcessdetection of light stimulus

OPN1MW2 OPN1MW3 OPN1LW OPN1MW

1.69e-0477744GO:0009583
GeneOntologyBiologicalProcesspositive regulation of response to food

OR4M2 OR4M1

2.64e-047742GO:0032097
GeneOntologyBiologicalProcesspositive regulation of appetite

OR4M2 OR4M1

2.64e-047742GO:0032100
GeneOntologyBiologicalProcesspositive regulation of response to nutrient levels

OR4M2 OR4M1

3.51e-048742GO:0032109
GeneOntologyBiologicalProcessdetection of external stimulus

OPN1MW2 OPN1MW3 OPN1LW OPN1MW CHRNA10

3.95e-04173745GO:0009581
GeneOntologyBiologicalProcessdetection of abiotic stimulus

OPN1MW2 OPN1MW3 OPN1LW OPN1MW CHRNA10

4.17e-04175745GO:0009582
GeneOntologyBiologicalProcessadenylate cyclase-modulating G protein-coupled receptor signaling pathway

OR4M2 ADCY4 OR4M1 ADGRE1 ADCY9 FFAR4

5.67e-04286746GO:0007188
GeneOntologyBiologicalProcesscellular response to radiation

OPN1MW2 OPN1MW3 OPN1LW CASP9 OPN1MW

6.66e-04194745GO:0071478
GeneOntologyBiologicalProcesscAMP biosynthetic process

ADCY4 ADCY9

6.84e-0411742GO:0006171
GeneOntologyCellularComponentphotoreceptor disc membrane

OPN1MW2 OPN1MW3 OPN1LW OPN1MW

2.04e-0626744GO:0097381
HumanPhenoBlue cone monochromacy

OPN1LW OPN1MW

8.09e-062152HP:0007939
HumanPhenoCone monochromacy

OPN1LW OPN1MW

8.09e-062152HP:0011517
HumanPhenoReduced OCT-measured foveal thickness

OPN1LW OPN1MW

2.42e-053152HP:0030619
HumanPhenoAbnormal OCT-measured foveal thickness

OPN1LW OPN1MW

4.84e-054152HP:0030617
Domain7tm_1

OR8H2 OR6F1 OR7D4 OR6B1 OPN1MW3 OR4M2 OR6V1 OR7C2 OR1J1 F2RL3 OR6C4 OR4M1 OR1D5 OPN1LW OR1G1 OR52E5 OR1F2P OPN1MW OR51G1 OR7A17 OR11H12 OR1D4 OR1J4 FFAR4 OR1D2

5.74e-196776925PF00001
DomainG_PROTEIN_RECEP_F1_1

OR8H2 OR6F1 OR7D4 OR6B1 OPN1MW3 OR4M2 OR6V1 OR7C2 OR1J1 F2RL3 OR6C4 OR4M1 OR1D5 OPN1LW OR1G1 OR52E5 OR1F2P OPN1MW OR51G1 OR7A17 OR11H12 OR1D4 OR1J4 FFAR4 OR1D2

7.60e-196856925PS00237
DomainG_PROTEIN_RECEP_F1_2

OR8H2 OR6F1 OR7D4 OR6B1 OPN1MW3 OR4M2 OR6V1 OR7C2 OR1J1 F2RL3 OR6C4 OR4M1 OR1D5 OPN1LW OR1G1 OR52E5 OR1F2P OPN1MW OR51G1 OR7A17 OR11H12 OR1D4 OR1J4 FFAR4 OR1D2

9.35e-196916925PS50262
DomainGPCR_Rhodpsn

OR8H2 OR6F1 OR7D4 OR6B1 OPN1MW3 OR4M2 OR6V1 OR7C2 OR1J1 F2RL3 OR6C4 OR4M1 OR1D5 OPN1LW OR1G1 OR52E5 OR1F2P OPN1MW OR51G1 OR7A17 OR11H12 OR1D4 OR1J4 FFAR4 OR1D2

9.68e-196926925IPR000276
DomainOlfact_rcpt

OR8H2 OR6F1 OR7D4 OR6B1 OR4M2 OR6V1 OR7C2 OR1J1 OR6C4 OR4M1 OR1D5 OR1G1 OR52E5 OR1F2P OR51G1 OR7A17 OR11H12 OR1D4 OR1J4 OR1D2

8.06e-183936920IPR000725
DomainGPCR_Rhodpsn_7TM

OR8H2 OR6F1 OR7D4 OR6B1 OPN1MW3 OR4M2 OR6V1 OR7C2 OR1J1 F2RL3 OR6C4 OR4M1 OR1D5 OPN1LW OR1G1 OPN1MW OR51G1 OR7A17 OR11H12 OR1J4 FFAR4 OR1D2

1.38e-156706922IPR017452
DomainOpsin_red/grn

OPN1MW3 OPN1LW OPN1MW

4.83e-083693IPR000378
DomainOPSIN

OPN1MW3 OPN1LW OPN1MW

5.68e-0610693PS00238
DomainOpsin

OPN1MW3 OPN1LW OPN1MW

7.80e-0611693IPR001760
DomainA/G_cyclase_CS

ADCY4 ADCY9

1.76e-0317692IPR018297
DomainNucleotide_cyclase

ADCY4 ADCY9

1.98e-0318692IPR029787
Domain-

ADCY4 ADCY9

1.98e-03186923.30.70.1230
DomainGUANYLATE_CYCLASE_1

ADCY4 ADCY9

2.21e-0319692PS00452
DomainGuanylate_cyc

ADCY4 ADCY9

2.21e-0319692PF00211
DomainGUANYLATE_CYCLASE_2

ADCY4 ADCY9

2.21e-0319692PS50125
DomainA/G_cyclase

ADCY4 ADCY9

2.21e-0319692IPR001054
DomainCYCc

ADCY4 ADCY9

2.21e-0319692SM00044
PathwayREACTOME_OLFACTORY_SIGNALING_PATHWAY

OR8H2 OR6F1 OR7D4 OR6B1 OR4M2 OR6V1 OR7C2 OR1J1 OR11H7 OR6C4 OR4M1 OR1D5 OR1E3 OR1G1 OR52E5 OR51G1 OR7A17 OR1D4 OR1J4 OR1D2

4.95e-174175620M4072
PathwayREACTOME_SENSORY_PERCEPTION

OR8H2 OR6F1 OR7D4 OR6B1 OR4M2 OR6V1 OR7C2 OR1J1 OR11H7 OR6C4 OR4M1 OR1D5 OPN1LW OR1E3 OR1G1 OR52E5 OPN1MW OR51G1 OR7A17 CHRNA10 OR1D4 OR1J4 OR1D2

5.92e-176365623M41834
PathwayKEGG_OLFACTORY_TRANSDUCTION

OR8H2 OR6F1 OR7D4 OR6B1 OR4M2 OR6V1 OR7C2 OR1J1 OR6C4 OR4M1 OR1D5 OR1G1 OR51G1 OR7A17 OR1D4 OR1J4 OR1D2

8.08e-143895617M14091
PathwayWP_GPCRS_CLASS_A_RHODOPSINLIKE

OR6B1 OR7C2 F2RL3 OR1D5 OPN1LW OR1G1 OPN1MW OR7A17 OR1D4 OR1D2

6.47e-082605610M39397
PathwayWP_GPCRS_OTHER

OR1J1 OR1D5 OR1E3 OR1F2P OR7A17 OR7A2P OR1D2

9.61e-0896567MM15939
PathwayWP_GPCRS_ODORANT

OPN1MW2 OR7D4 OPN1MW3 OR1J1 OPN1LW OR1E3 OR7A17 OR7A2P

1.79e-07157568MM15872
PathwayREACTOME_SENSORY_PERCEPTION

OPN1MW2 OR6F1 OR7D4 OPN1MW3 OR1D5 OPN1LW OR1E3 OR1D2

7.68e-07190568MM15687
PathwayREACTOME_THE_RETINOID_CYCLE_IN_CONES_DAYLIGHT_VISION

OPN1MW2 OPN1MW3 OPN1LW

3.28e-068563MM14880
PathwayREACTOME_OPSINS

OPN1MW2 OPN1MW3 OPN1LW

6.99e-0610563MM15063
PathwayREACTOME_OLFACTORY_SIGNALING_PATHWAY

OR6F1 OR7D4 OR1D5 OR1E3 OR1D2

8.20e-0670565MM14984
PathwayWP_GPCRS_CLASS_A_RHODOPSINLIKE

OPN1MW2 OPN1MW3 F2RL3 OPN1LW OR7A17 OR7A2P

9.14e-05186566MM15994
PathwayREACTOME_THE_RETINOID_CYCLE_IN_CONES_DAYLIGHT_VISION

OPN1LW OPN1MW

3.21e-047562M27157
PathwayREACTOME_OPSINS

OPN1LW OPN1MW

5.48e-049562M6285
PathwayREACTOME_ADENYLATE_CYCLASE_ACTIVATING_PATHWAY

ADCY4 ADCY9

6.83e-0410562M19522
PathwayREACTOME_ADENYLATE_CYCLASE_ACTIVATING_PATHWAY

ADCY4 ADCY9

6.83e-0410562MM14668
PathwayREACTOME_G_ALPHA_Z_SIGNALLING_EVENTS

ADCY4 RGSL1 ADCY9

9.05e-0448563M10775
PathwayREACTOME_SIGNALING_BY_GPCR

OPN1MW2 OPN1MW3 ADCY4 RGSL1 F2RL3 OPN1LW ADGRE1 ADCY9 FFAR4

9.25e-04646569MM14962
PathwayREACTOME_RETINOID_CYCLE_DISEASE_EVENTS

OPN1LW OPN1MW

1.18e-0313562M29612
PathwayREACTOME_ADENYLATE_CYCLASE_INHIBITORY_PATHWAY

ADCY4 ADCY9

1.37e-0314562MM14669
PathwayREACTOME_ADENYLATE_CYCLASE_INHIBITORY_PATHWAY

ADCY4 ADCY9

1.37e-0314562M750
PathwayKEGG_MEDICUS_REFERENCE_EP_NE_ADRB_CAMP_SIGNALING_PATHWAY

ADCY4 ADCY9

1.57e-0315562M47794
PathwayPID_LPA4_PATHWAY

ADCY4 ADCY9

1.57e-0315562M56
PathwayKEGG_MEDICUS_REFERENCE_PTH_PTH1R_PKA_SIGNALING_PATHWAY

ADCY4 ADCY9

1.57e-0315562M47504
PathwayWP_MAJOR_RECEPTORS_TARGETED_BY_EPINEPHRINE_AND_NOREPINEPHRINE

ADCY4 ADCY9

1.79e-0316562M39849
PathwayKEGG_MEDICUS_REFERENCE_LHCGR_GNAS_PKA_SIGNALING_PATHWAY

ADCY4 ADCY9

1.79e-0316562M47645
PathwayKEGG_MEDICUS_REFERENCE_FSHR_GNAS_PKA_SIGNALING_PATHWAY

ADCY4 ADCY9

1.79e-0316562M47650
PathwayREACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB

ADCY4 ADCY9

1.79e-0316562MM14492
Pubmed

The human olfactory receptor gene family.

OR8H2 OR6F1 OR7D4 OR6B1 OR4M2 OR6V1 OR7C2 OR1J1 OR11H7 OR6C4 OR4M1 OR1D5 OR1E3 OR1G1 OR52E5 OR1F2P OR51G1 OR7A17 OR1D4 OR7A2P OR1J4 OR1D2

2.62e-22541752214983052
Pubmed

Different evolutionary processes shaped the mouse and human olfactory receptor gene families.

OR8H2 OR6F1 OR7D4 OR6B1 OR4M2 OR7C2 OR1J1 OR11H7 OR4M1 OR1D5 OR1E3 OR52E5 OR1F2P OR51G1 OR7A17 OR7A2P OR1J4 OR1D2

2.44e-20340751811875048
Pubmed

The olfactory receptor gene superfamily of the mouse.

OR8H2 OR6F1 OR7D4 OR6B1 OR4M2 OR7C2 OR1J1 OR11H7 OR4M1 OR1D5 OR1E3 OR52E5 OR1F2P OR51G1 OR7A17 OR7A2P OR1J4 OR1D2

2.44e-20340751811802173
Pubmed

A unified nomenclature for vertebrate olfactory receptors.

OR8H2 OR6F1 OR7D4 OR6B1 OR4M2 OR7C2 OR1J1 OR11H7 OR4M1 OR1D5 OR1E3 OR52E5 OR1F2P OR51G1 OR7A17 OR7A2P OR1J4 OR1D2

2.86e-20343751832295537
Pubmed

Odorant receptor expressed sequence tags demonstrate olfactory expression of over 400 genes, extensive alternate splicing and unequal expression levels.

OR8H2 OR6F1 OR7D4 OR6B1 OR4M2 OR7C2 OR1J1 OR11H7 OR4M1 OR1D5 OR1E3 OR52E5 OR1F2P OR51G1 OR7A17 OR7A2P OR1J4 OR1D2

3.35e-20346751814611657
Pubmed

DEFOG: a practical scheme for deciphering families of genes.

OR6F1 OR7D4 OR6B1 OR7C2 OR1J1 OR11H7 OR1D5 OR1F2P OR7A17 OR1D4 OR7A2P OR1J4 OR1D2

1.53e-15219751312213199
Pubmed

Human L- and M-opsins restore M-cone function in a mouse model for human blue cone monochromacy.

OPN1MW2 OPN1MW3 OPN1LW OPN1MW

1.99e-11475429386880
Pubmed

Molecular genetics of human color vision: the genes encoding blue, green, and red pigments.

OPN1MW2 OPN1MW3 OPN1LW OPN1MW

9.95e-1157542937147
Pubmed

Sequence, structure, and evolution of a complete human olfactory receptor gene cluster.

OR1D5 OR1E3 OR1G1 OR1D4 OR1D2

1.75e-101675510673334
Pubmed

The olfactory receptor gene repertoire in primates and mouse: evidence for reduction of the functional fraction in primates.

OR7C2 OR1E3 OR1F2P OR7A17 OR7A2P

1.33e-092375510706615
Pubmed

Olfactory receptor gene cluster on human chromosome 17: possible duplication of an ancestral receptor repertoire.

OR1E3 OR1G1 OR1D4 OR1D2

6.51e-09117548004088
Pubmed

Molecular determinants of human red/green color discrimination.

OPN1MW2 OPN1LW OPN1MW

9.63e-0937538185948
Pubmed

X-linked cone dystrophy caused by mutation of the red and green cone opsins.

OPN1MW2 OPN1LW OPN1MW

9.63e-09375320579627
Pubmed

Expression of red/green-cone opsin mutants K82E, P187S, M273K result in unique pathobiological perturbations to cone structure and function.

OPN1MW2 OPN1MW3 OPN1LW

9.63e-09375338410159
Pubmed

Chloride-dependent spectral tuning mechanism of L-group cone visual pigments.

OPN1MW2 OPN1MW3 OPN1LW

9.63e-09375323350963
Pubmed

Distinct contributions of rod, cone, and melanopsin photoreceptors to encoding irradiance.

OPN1MW2 OPN1MW3 OPN1LW

9.63e-09375320471354
Pubmed

Multiple hypothalamic cell populations encoding distinct visual information.

OPN1MW2 OPN1MW3 OPN1LW

9.63e-09375321224225
Pubmed

Circadian Regulation of the Rod Contribution to Mesopic Vision in Mice.

OPN1MW2 OPN1MW3 OPN1LW

9.63e-09375336216501
Pubmed

Spectral tuning of a circadian photopigment in a subterranean 'blind' mammal (Spalax ehrenbergi).

OPN1MW2 OPN1MW3 OPN1LW

9.63e-09375310567724
Pubmed

Extensive cone-dependent spectral opponency within a discrete zone of the lateral geniculate nucleus supporting mouse color vision.

OPN1MW2 OPN1MW3 OPN1LW

9.63e-09375334111401
Pubmed

Genetically engineered mice with an additional class of cone photoreceptors: implications for the evolution of color vision.

OPN1MW2 OPN1MW3 OPN1LW

9.63e-09375314500905
Pubmed

Gene-based Therapy in a Mouse Model of Blue Cone Monochromacy.

OPN1MW2 OPN1MW3 OPN1LW

9.63e-09375328751656
Pubmed

Rescue of M-cone Function in Aged Opn1mw-/- Mice, a Model for Late-Stage Blue Cone Monochromacy.

OPN1MW2 OPN1MW3 OPN1LW

9.63e-09375331469404
Pubmed

The molecular genetics and evolution of red and green color vision in vertebrates.

OPN1MW2 OPN1MW3 OPN1LW

9.63e-09375311545071
Pubmed

Mechanisms of spectral tuning in the mouse green cone pigment.

OPN1MW2 OPN1MW3 OPN1LW

9.63e-0937539238068
Pubmed

Emergence of novel color vision in mice engineered to express a human cone photopigment.

OPN1MW2 OPN1MW3 OPN1LW

9.63e-09375317379811
Pubmed

Co-expression of murine opsins facilitates identifying the site of cone adaptation.

OPN1MW2 OPN1MW3 OPN1LW

9.63e-09375312511072
Pubmed

The Pem homeobox gene is X-linked and exclusively expressed in extraembryonic tissues during early murine development.

OPN1MW2 OPN1MW3 OPN1LW

9.63e-0937537958444
Pubmed

Visual responses in the dorsal lateral geniculate nucleus at early stages of retinal degeneration in rd1 PDE6β mice.

OPN1MW2 OPN1MW3 OPN1LW

3.85e-08475331461375
Pubmed

Murine and bovine blue cone pigment genes: cloning and characterization of two new members of the S family of visual pigments.

OPN1MW2 OPN1MW3 OPN1LW

3.85e-0847538088841
Pubmed

Modulation of Fast Narrowband Oscillations in the Mouse Retina and dLGN According to Background Light Intensity.

OPN1MW2 OPN1MW3 OPN1LW

3.85e-08475328103478
Pubmed

Molecular biology of the visual pigments.

OPN1MW2 OPN1LW OPN1MW

3.85e-0847533303660
Pubmed

Cones Support Alignment to an Inconsistent World by Suppressing Mouse Circadian Responses to the Blue Colors Associated with Twilight.

OPN1MW2 OPN1MW3 OPN1LW

3.85e-08475331846668
Pubmed

Melanopsin-driven increases in maintained activity enhance thalamic visual response reliability across a simulated dawn.

OPN1MW2 OPN1MW3 OPN1LW

3.85e-08475326438865
Pubmed

Light/dark translocation of alphatransducin in mouse photoreceptor cells expressing G90D mutant opsin.

OPN1MW2 OPN1MW3 OPN1LW

3.85e-08475317249565
Pubmed

Structural and functional rescue of cones carrying the most common cone opsin C203R missense mutation.

OPN1MW2 OPN1MW3 OPN1LW

3.85e-08475338060327
Pubmed

Contribution of M-opsin-based color vision to refractive development in mice.

OPN1MW2 OPN1MW3 OPN1LW

3.85e-08475334126082
Pubmed

Physiological features of the S- and M-cone photoreceptors of wild-type mice from single-cell recordings.

OPN1MW2 OPN1MW3 OPN1LW

3.85e-08475316567464
Pubmed

S-opsin knockout mice with the endogenous M-opsin gene replaced by an L-opsin variant.

OPN1MW2 OPN1MW3 OPN1LW

3.85e-08475324801621
Pubmed

Melanopsin Contributions to the Representation of Images in the Early Visual System.

OPN1MW2 OPN1MW3 OPN1LW

3.85e-08475328528909
Pubmed

Melanopsin-driven light adaptation in mouse vision.

OPN1MW2 OPN1MW3 OPN1LW

3.85e-08475325308073
Pubmed

Chromosomal location-dependent nonstochastic onset of odor receptor expression.

OR7D4 OR6B1 OR7A17 OR7A2P

4.65e-081775420668191
Pubmed

Typing recombinant inbred mouse strains for microsatellite markers on chromosomes 10, 16, 18, 19, and X.

OPN1MW2 OPN1MW3 OSBP OPN1LW

9.41e-08207548589516
Pubmed

Noncoding Mutations in a Thyroid Hormone Receptor Gene That Impair Cone Photoreceptor Function.

OPN1MW2 OPN1MW3 OPN1LW

9.60e-08575336631163
Pubmed

Using Silent Substitution to Track the Mesopic Transition From Rod- to Cone-Based Vision in Mice.

OPN1MW2 OPN1MW3 OPN1LW

9.60e-08575326818794
Pubmed

A common integration locus in type B retrovirus-induced thymic lymphomas.

OPN1MW2 OPN1MW3 OPN1LW

9.60e-0857531333116
Pubmed

A distinct contribution of short-wavelength-sensitive cones to light-evoked activity in the mouse pretectal olivary nucleus.

OPN1MW2 OPN1MW3 OPN1LW

9.60e-08575322090509
Pubmed

Comparative sequence analysis of the MECP2-locus in human and mouse reveals new transcribed regions.

OPN1MW2 OPN1MW3 OPN1LW

9.60e-08575310723722
Pubmed

Peripherin-2 differentially interacts with cone opsins in outer segments of cone photoreceptors.

OPN1MW2 OPN1MW3 OPN1LW

9.60e-08575327033727
Pubmed

Melanopsin-based brightness discrimination in mice and humans.

OPN1MW2 OPN1MW3 OPN1LW

9.60e-08575322633808
Pubmed

The murine cone photoreceptor: a single cone type expresses both S and M opsins with retinal spatial patterning.

OPN1MW2 OPN1MW3 OPN1LW

9.60e-08575311055434
Pubmed

Enhancer/promoter activities of the long/middle wavelength-sensitive opsins of vertebrates mediated by thyroid hormone receptor β2 and COUP-TFII.

OPN1MW2 OPN1MW3 OPN1LW

9.60e-08575324058409
Pubmed

Variations in photoreceptor throughput to mouse visual cortex and the unique effects on tuning.

OPN1MW2 OPN1MW3 OPN1LW

9.60e-08575334099749
Pubmed

Functional comparison of rod and cone Gα(t) on the regulation of light sensitivity.

OPN1MW2 OPN1MW3 OPN1LW

1.92e-07675323288843
Pubmed

Reduced levels of dystrophin associated proteins in the brains of mice deficient for Dp71.

OPN1MW2 OPN1MW3 OPN1LW

1.92e-0767538872469
Pubmed

A thyroid hormone receptor that is required for the development of green cone photoreceptors.

OPN1MW2 OPN1MW3 OPN1LW

1.92e-07675311138006
Pubmed

Impaired cytokine signaling in mice lacking the IL-1 receptor-associated kinase.

OPN1MW2 OPN1MW3 OPN1LW

1.92e-07675310395695
Pubmed

Transient expression of thyroid hormone nuclear receptor TRbeta2 sets S opsin patterning during cone photoreceptor genesis.

OPN1MW2 OPN1MW3 OPN1LW

1.92e-07675317436273
Pubmed

Telomere-related markers for the pseudoautosomal region of the mouse genome.

OPN1MW2 OPN1MW3 OPN1LW

1.92e-0767531549575
Pubmed

Expression of members of the putative olfactory receptor gene family in mammalian germ cells.

OR1F2P OR7A17 OR1J4 OR1D2

2.44e-07257541370859
Pubmed

Retarded developmental expression and patterning of retinal cone opsins in hypothyroid mice.

OPN1MW2 OPN1MW3 OPN1LW

3.35e-07775318974269
Pubmed

Genetic and physical mapping of a gene encoding a methyl CpG binding protein, Mecp2, to the mouse X chromosome.

OPN1MW2 OPN1MW3 OPN1LW

3.35e-0777538001979
Pubmed

NeuroD1 regulates expression of thyroid hormone receptor 2 and cone opsins in the developing mouse retina.

OPN1MW2 OPN1MW3 OPN1LW

3.35e-07775318199774
Pubmed

Mapping of the murine tbl1 gene reveals a new rearrangement between mouse and human X Chromosomes.

OPN1MW2 OPN1MW3 OPN1LW

3.35e-0777539880679
Pubmed

Characterization of cDNAs encoding the murine interleukin 2 receptor (IL-2R) gamma chain: chromosomal mapping and tissue specificity of IL-2R gamma chain expression.

OPN1MW2 OPN1MW3 OPN1LW

3.35e-0777538378320
Pubmed

Rod Photoreceptor Activation Alone Defines the Release of Dopamine in the Retina.

OPN1MW2 OPN1MW3 OPN1LW

3.35e-07775330799247
Pubmed

Activation of the blue opsin gene in cone photoreceptor development by retinoid-related orphan receptor beta.

OPN1MW2 OPN1MW3 OPN1LW

3.35e-07775316574740
Pubmed

Rods progressively escape saturation to drive visual responses in daylight conditions.

OPN1MW2 OPN1MW3 OPN1LW

3.35e-07775329180667
Pubmed

Cloning and distribution of myosin 3B in the mouse retina: differential distribution in cone outer segments.

OPN1MW2 OPN1MW3 OPN1LW

3.35e-07775319332056
Pubmed

Identification and genetic mapping of differentially expressed genes in mice differing at the If1 interferon regulatory locus.

OPN1MW2 OPN1MW3 ERBB2 OPN1LW OR7A17

3.54e-076775510441734
Pubmed

Chromatin Remodeling Enzyme Snf2h Is Essential for Retinal Cell Proliferation and Photoreceptor Maintenance.

OPN1MW2 OPN1MW3 OPN1LW CASP9

5.24e-073075437048108
Pubmed

Localization of the mdx mutation within the mouse dystrophin gene.

OPN1MW2 OPN1MW3 OPN1LW

5.35e-0787532903046
Pubmed

Genetic mapping on the mouse X chromosome of human cDNA clones for the fragile X and Hunter syndromes.

OPN1MW2 OPN1MW3 OPN1LW

5.35e-0787531572654
Pubmed

Two transcription factors can direct three photoreceptor outcomes from rod precursor cells in mouse retinal development.

OPN1MW2 OPN1MW3 OPN1LW

5.35e-07875321813673
Pubmed

X-chromosome gene order in different Mus species crosses.

OPN1MW2 OPN1MW3 OPN1LW

5.35e-0787533416629
Pubmed

The retinitis pigmentosa GTPase regulator (RPGR)- interacting protein: subserving RPGR function and participating in disk morphogenesis.

OPN1MW2 OPN1MW3 OPN1LW

5.35e-07875312651948
Pubmed

Transcriptional profiling of murine retinas undergoing semi-synchronous cone photoreceptor differentiation.

OPN1MW2 OPN1MW3 OPN1LW

5.35e-07875331163126
Pubmed

Type 3 deiodinase, a thyroid-hormone-inactivating enzyme, controls survival and maturation of cone photoreceptors.

OPN1MW2 OPN1MW3 OPN1LW

5.35e-07875320203194
Pubmed

Tubby is required for trafficking G protein-coupled receptors to neuronal cilia.

OPN1MW2 OPN1MW3 OPN1LW

5.35e-07875323351594
Pubmed

Mouse-human orthology relationships in an olfactory receptor gene cluster.

OR1D5 OR1E3 OR1D2

5.35e-07875311170746
Pubmed

A retinitis pigmentosa GTPase regulator (RPGR)-deficient mouse model for X-linked retinitis pigmentosa (RP3).

OPN1MW2 OPN1MW3 OPN1LW

5.35e-07875310725384
Pubmed

Retinoid X receptor (gamma) is necessary to establish the S-opsin gradient in cone photoreceptors of the developing mouse retina.

OPN1MW2 OPN1MW3 OPN1LW

5.35e-07875316043864
Pubmed

Nr2e3 functional domain ablation by CRISPR-Cas9D10A identifies a new isoform and generates retinitis pigmentosa and enhanced S-cone syndrome models.

OPN1MW2 OPN1MW3 OPN1LW

5.35e-07875333007388
Pubmed

Linkage of amelogenin (Amel) to the distal portion of the mouse X chromosome.

OPN1MW2 OPN1MW3 OPN1LW

5.35e-0787531675194
Pubmed

Retinal dystrophy resulting from ablation of RXR alpha in the mouse retinal pigment epithelium.

OPN1MW2 OPN1MW3 OPN1LW

8.02e-07975314742273
Pubmed

Feedback induction of a photoreceptor-specific isoform of retinoid-related orphan nuclear receptor β by the rod transcription factor NRL.

OPN1MW2 OPN1MW3 OPN1LW

8.02e-07975325296752
Pubmed

Comparative mapping of the actin-binding protein 280 genes in human and mouse.

OPN1MW2 OPN1MW3 OPN1LW

8.02e-0797538088838
Pubmed

ZBED4, a cone and Müller cell protein in human retina, has a different cellular expression in mouse.

OPN1MW2 OPN1MW3 OPN1LW

8.02e-07975321850176
Pubmed

Top2b is involved in the formation of outer segment and synapse during late-stage photoreceptor differentiation by controlling key genes of photoreceptor transcriptional regulatory network.

OPN1MW2 OPN1MW3 OPN1LW

8.02e-07975328370415
Pubmed

IFT20 is required for opsin trafficking and photoreceptor outer segment development.

OPN1MW2 OPN1MW3 OPN1LW

8.02e-07975321307337
Pubmed

Multilocus molecular mapping of the mouse X chromosome.

OPN1MW2 OPN1MW3 OPN1LW

8.02e-0797532906327
Pubmed

A visual circuit uses complementary mechanisms to support transient and sustained pupil constriction.

OPN1MW2 OPN1MW3 OPN1LW

8.02e-07975327669145
Pubmed

Close linkage of the murine locus bare patches to the X-linked visual pigment gene: implications for mapping human X-linked dominant chondrodysplasia punctata.

OPN1MW2 OPN1MW3 OPN1LW

8.02e-0797531973136
Pubmed

Distinct functions of photoreceptor cell-specific nuclear receptor, thyroid hormone receptor beta2 and CRX in one photoreceptor development.

OPN1MW2 OPN1MW3 OPN1LW

8.02e-07975312407160
Pubmed

Mapping of ornithine aminotransferase gene sequences to mouse chromosomes 7, X, and 3.

OPN1MW2 OPN1MW3 OPN1LW

1.14e-06107531349842
Pubmed

Cyclophilin-related protein RanBP2 acts as chaperone for red/green opsin.

OPN1MW2 OPN1LW OPN1MW

1.14e-06107538857542
Pubmed

Linkage of a gene for neural cell adhesion molecule, L1 (CamL1) to the Rsvp region of the mouse X chromosome.

OPN1MW2 OPN1MW3 OPN1LW

1.14e-06107531964443
Pubmed

Vax2 regulates retinoic acid distribution and cone opsin expression in the vertebrate eye.

OPN1MW2 OPN1MW3 OPN1LW

1.14e-061075321148184
Pubmed

Fam151b, the mouse homologue of C.elegans menorin gene, is essential for retinal function.

OPN1MW2 OPN1MW3 OPN1LW

1.14e-061075331949211
Pubmed

Comparative mapping on the mouse and human X chromosomes of a human cDNA clone encoding the vasopressin renal-type receptor (AVP2R).

OPN1MW2 OPN1MW3 OPN1LW

1.14e-06107538449515
Cytoband17p13.3

OR1D5 OR1E3 OR1G1 OR1D4 OR1D2

3.58e-078875517p13.3
CytobandEnsembl 112 genes in cytogenetic band chr17p13

SHPK OR1D5 OR1E3 OR1G1 OR1D4 OR1D2

2.28e-05346756chr17p13
CytobandEnsembl 112 genes in cytogenetic band chrXq28

OPN1MW2 OPN1MW3 OPN1LW OPN1MW

4.23e-04213754chrXq28
Cytoband1p12

WDR3 SLC16A1

7.71e-04257521p12
CytobandEnsembl 112 genes in cytogenetic band chr9q33

OR1J1 DENND1A OR1J4

1.53e-03138753chr9q33
CytobandEnsembl 112 genes in cytogenetic band chr19p13

OR7D4 OR7C2 F2RL3 OR7A17 ADGRE1 OR7A2P

1.96e-03797756chr19p13
CytobandXq28

OPN1MW2 OPN1LW OPN1MW

3.05e-03176753Xq28
Cytoband19p13.12

OR7A17 OR7A2P

3.07e-035075219p13.12
Cytoband14q11.2

OR11H7 OR4M1 OR11H12

3.25e-0318075314q11.2
GeneFamilyOlfactory receptors, family 1

OR1J1 OR1D5 OR1E3 OR1G1 OR1F2P OR1D4 OR1J4 OR1D2

8.45e-1340628147
GeneFamilyOpsin receptors

OPN1MW2 OPN1MW3 OPN1LW OPN1MW

4.06e-0811624215
GeneFamilyOlfactory receptors, family 6

OR6F1 OR6B1 OR6V1 OR6C4

2.78e-0551624153
GeneFamilyAdenylate cyclases|Deafness associated genes

ADCY4 ADCY9

5.12e-041062253
GeneFamilyOlfactory receptors, family 7

OR7D4 OR7C2 OR7A17 OR7A2P

6.10e-04113624154
GeneFamilyOlfactory receptors, family 11

OR11H7 OR11H12

2.79e-0323622159
DrugRamipril [87333-19-5]; Down 200; 9.6uM; HL60; HT_HG-U133A

BRF1 TMEM212 OR1G1 TNS2 DDX43 CHRNA10 WDR76

2.73e-062007076150_DN
Diseaseblue cone monochromacy (implicated_via_orthology)

OPN1MW2 OPN1MW3 OPN1LW OPN1MW

2.01e-114644DOID:0050679 (implicated_via_orthology)
DiseaseBORNHOLM EYE DISEASE

OPN1LW OPN1MW

4.63e-062642C3159311
DiseaseAchromatopsia incomplete, X-linked

OPN1LW OPN1MW

4.63e-062642C2931753
DiseaseCone monochromatism

OPN1LW OPN1MW

4.63e-062642C0339537
DiseaseBLUE CONE MONOCHROMACY

OPN1LW OPN1MW

4.63e-062642303700
DiseaseRed-green dyschromatopsia

OPN1LW OPN1MW

4.63e-062642cv:C0155016
DiseaseCone monochromatism

OPN1LW OPN1MW

4.63e-062642cv:C0339537
Diseaseblue cone monochromacy (is_implicated_in)

OPN1LW OPN1MW

4.63e-062642DOID:0050679 (is_implicated_in)
Diseaselaryngeal carcinoma (is_marker_for)

KMT2C TRAF6

6.91e-056642DOID:2600 (is_marker_for)
DiseaseParkinson's disease (is_implicated_in)

DNAJC13 FBXO7 CASP9

6.11e-0476643DOID:14330 (is_implicated_in)
DiseaseIntrahepatic Cholangiocarcinoma

KMT2C ERBB2

1.24e-0324642C0345905
Diseasestomach carcinoma (is_marker_for)

KMT2C ERBB2

1.24e-0324642DOID:5517 (is_marker_for)
DiseaseExtrahepatic Cholangiocarcinoma

KMT2C ERBB2

1.24e-0324642C3805278
DiseaseCholangiocarcinoma

KMT2C ERBB2

1.46e-0326642C0206698
DiseaseCone-Rod Dystrophy 2

OPN1LW OPN1MW

1.81e-0329642C3489532
Diseaseglomerular filtration rate, renal transplant outcome measurement

OR1D5 OR1D4

2.63e-0335642EFO_0005199, EFO_0005208
Diseaselung adenocarcinoma (is_implicated_in)

KMT2C ERBB2

5.10e-0349642DOID:3910 (is_implicated_in)

Protein segments in the cluster

PeptideGeneStartEntry
TILIMNLHYCGPSVR

CHRNA10

316

Q9GZZ6
LVTQLMPYGCLLDHV

ERBB2

796

P04626
PLMLSVLNGHTDCVY

ANKRD28

656

O15084
ISVPYSMHCCTLGFL

ADCY4

716

Q8NFM4
CFLTMHSYGQLILTP

CPO

231

Q8IVL8
LGHPMCVLEGYTVSL

OPN1LW

121

P04000
LGHPMCVLEGYTVSL

OPN1MW3

121

P0DN78
LHYTVIMSPQLCGLL

OR7A2P

131

Q8NGA2
IAEGVCIPRSALYMH

RFX4

71

Q33E94
LTPIYGLTMKHARCE

CYP1A2

491

P05177
LGHPMCVLEGYTVSL

OPN1MW2

121

P0DN77
TCYSHITIVVLMFGP

OR4M2B

241

A0A0X1KG70
GVCHMLAPLSTTYVG

SLC16A1

341

P53985
ICSPLHYTVIMSKRL

OR8H2

126

Q8N162
YHGMCLDIAVTPLKR

KMT2C

366

Q8NEZ4
SPYMQCLASLAVGLH

HERC1

3881

Q15751
LGPVACHLLFYVMTL

FFAR4

106

Q5NUL3
HICAVLLFYIPMIGL

OR51G1

246

Q8NGK1
TCYSHITIVVLMFGP

OR4M1

241

Q8NGD0
TCYSHITIVVLMFGP

OR4M2

241

Q8NGB6
AIMLPFLCILVSYGH

OR1J1

206

Q8NGS3
KPLHYLTIMSSRVCI

OR6C4

126

Q8NGE1
GKYLSIMPLGTIHCI

OSBP

551

P22059
ICHPLRYTTIMKEGL

OR1J4

126

Q8NGS1
ICHPLHYILIMSPGL

OR1G1

126

P47890
HYILIMSPGLCIFLV

OR1G1

131

P47890
TITPFLCLLASYMHI

OR1F2P

206

Q96R84
LGHPMCVLEGYTVSL

OPN1MW

121

P04001
PLLAMLLCYGATLHT

F2RL3

256

Q96RI0
FVAICHPLRYGTLMS

OR6V1

121

Q8N148
HYTVIMNPCLCGLLV

OR7D4

131

Q8NG98
PSLGVQGVMHLTLYC

FASTKD5

386

Q7L8L6
LQYMHPLCEGSSATL

FBXO7

236

Q9Y3I1
HPYLGCIVMTLAVLQ

FRRS1

446

Q6ZNA5
LAYILSMEPCGHCLI

CASP9

151

P55211
TVMHLPLYLSLCLGV

ADCY9

236

O60503
GLTALSMCFLLHYPA

ANKMY1

326

Q9P2S6
SILGHILPEAMVCYL

DNAJC13

1166

O75165
TLTACIHGSAAMLYP

DENND1A

206

Q8TEH3
LAVYKCQSMGLLPTH

EMC4

146

Q5J8M3
PISTLHCTGSYVMAL

HIRA

776

P54198
MLYCVLFHGTILDPS

SCAPER

1186

Q9BY12
GKTLCYLMPGFIHLV

DDX43

291

Q9NXZ2
HYTTIMSPKCCLGLL

OR1E3

131

Q8WZA6
LYPNIMTGHLCAKLV

OR11H12

146

B2RN74
HYPSIMTGQLCGILV

OR11H7

131

Q8NGC8
ICYPLHYGAIMSSLL

OR6F1

126

Q8NGZ6
HYTVIMNPRLCGLLV

OR7C2

131

O60412
VHLCHGMSYPISGLV

ADHFE1

326

Q8IWW8
HYTTAMSPKLCILLL

OR1D2

131

P34982
HYVTAMSPGLCVLLL

OR1D4

131

P47884
HYVTAMSPGLCVLLL

OR1D5

131

P58170
GSHVCVMLAFYLPAL

OR52E5

241

Q8NH55
SVCYTHIGGLPLNMS

RGSL1

221

A5PLK6
VGILMSIVCYLSLPH

SLC29A2

201

Q14542
CYMLLGPVPILHIKS

SLC18B1

316

Q6NT16
MPLKHYLLLLVGCQA

LRRC15

1

Q8TF66
GTIHDYVVAMLCGLP

SHPK

176

Q9UHJ6
APILCVQSHLGYTEM

TANC2

886

Q9HCD6
VVPGHLVFLYTISCM

SLC41A1

416

Q8IVJ1
HYTVIMNPRLCGLLV

OR7A17

131

O14581
ICRPLHYPTIMSHGL

OR6B1

126

O95007
LHICAFGYGLPMLVV

ADGRE1

711

Q14246
LYPLHLASMSLACIG

TMEM196

106

Q5HYL7
VILSIMGCPLHFAIA

TMEM212

81

A6NML5
GQDSVPYMICLIHIL

TMEM68

11

Q96MH6
ICLVMSLLLQHPGVY

MSMP

21

Q1L6U9
IAGLCMLKLYQTRHP

SIDT1

581

Q9NXL6
GYKLCMRLHLQLPTA

TRAF6

386

Q9Y4K3
STAMYGAHAPLLALC

SLC35A4

26

Q96G79
YIHNGLKLIMSCPSV

USP38

106

Q8NB14
LYLVCRTEGTPHMLL

BRF1

136

Q92994
CSINAMHPTRYILAG

WDR76

596

Q9H967
SLYGHKLPVICMDIS

WDR3

586

Q9UNX4
PALLLKGDVMVTCYH

TNS2

356

Q63HR2
LLRMYLSPPSIHCLG

VPS39

741

Q96JC1