Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
MousePheno	decreased glycogen catabolism rate	NHLRC1 MGAM CEBPB	1.71e-05	9	84	3	MP:0002715
MousePheno	abnormal glycogen catabolism	NHLRC1 MGAM CEBPB	3.34e-05	11	84	3	MP:0002713
Domain	PDZ	GIPC2 GIPC3 SHANK2 PARD3 SIPA1L2 NOS1 SNTA1 MPP7	1.21e-06	141	104	8	PF00595
Domain	PDZ	GIPC2 GIPC3 SHANK2 PARD3 SIPA1L2 NOS1 SNTA1 MPP7	1.74e-06	148	104	8	SM00228
Domain	-	GIPC2 GIPC3 SHANK2 PARD3 SIPA1L2 NOS1 SNTA1 MPP7	1.93e-06	150	104	8	2.30.42.10
Domain	PDZ	GIPC2 GIPC3 SHANK2 PARD3 SIPA1L2 NOS1 SNTA1 MPP7	2.03e-06	151	104	8	PS50106
Domain	PDZ	GIPC2 GIPC3 SHANK2 PARD3 SIPA1L2 NOS1 SNTA1 MPP7	2.13e-06	152	104	8	IPR001478
Domain	JIP_LZII	SPAG9 MAPK8IP3	3.07e-05	2	104	2	IPR032486
Domain	JIP_LZII	SPAG9 MAPK8IP3	3.07e-05	2	104	2	PF16471
Domain	Drf_DAD	DIAPH2 DIAPH3	9.18e-05	3	104	2	IPR010465
Domain	UCP038083_PDZ	GIPC2 GIPC3	9.18e-05	3	104	2	IPR017379
Domain	Drf_DAD	DIAPH2 DIAPH3	9.18e-05	3	104	2	PF06345
Domain	Jnk-SapK_ap_N	SPAG9 MAPK8IP3	1.83e-04	4	104	2	PF09744
Domain	JNK/Rab-associated_protein-1_N	SPAG9 MAPK8IP3	1.83e-04	4	104	2	IPR019143
Domain	RH2	SPAG9 MAPK8IP3	3.04e-04	5	104	2	PS51777
Domain	RH1	SPAG9 MAPK8IP3	3.04e-04	5	104	2	PS51776
Domain	DAD_dom	DIAPH2 DIAPH3	8.41e-04	8	104	2	IPR014767
Domain	DAD	DIAPH2 DIAPH3	8.41e-04	8	104	2	PS51231
Domain	Drf_GBD	DIAPH2 DIAPH3	1.08e-03	9	104	2	PF06371
Domain	FH3_dom	DIAPH2 DIAPH3	1.08e-03	9	104	2	IPR010472
Domain	GTPase-bd	DIAPH2 DIAPH3	1.08e-03	9	104	2	IPR010473
Domain	Drf_FH3	DIAPH2 DIAPH3	1.08e-03	9	104	2	PF06367
Domain	Drf_FH3	DIAPH2 DIAPH3	1.08e-03	9	104	2	SM01139
Domain	Drf_GBD	DIAPH2 DIAPH3	1.08e-03	9	104	2	SM01140
Domain	GBD/FH3_dom	DIAPH2 DIAPH3	1.63e-03	11	104	2	IPR014768
Domain	GBD_FH3	DIAPH2 DIAPH3	1.63e-03	11	104	2	PS51232
Domain	ARM-type_fold	ATR IFT172 RANBP6 APOB PPP2R5A DIAPH2 DIAPH3	2.88e-03	339	104	7	IPR016024
Domain	FH2	DIAPH2 DIAPH3	3.08e-03	15	104	2	PS51444
Domain	FH2_Formin	DIAPH2 DIAPH3	3.08e-03	15	104	2	IPR015425
Domain	FH2	DIAPH2 DIAPH3	3.08e-03	15	104	2	PF02181
Domain	FH2	DIAPH2 DIAPH3	3.08e-03	15	104	2	SM00498
Domain	LRR_6	TCTE1 NLRX1 NRROS	3.57e-03	55	104	3	PF13516
Domain	Leu-rich_rpt	TCTE1 NLRX1 SLITRK4 RTN4RL1 NRROS LRFN4	4.09e-03	271	104	6	IPR001611
Domain	Fd_Rdtase_FAD-bd	DUOX2 NOS1	4.94e-03	19	104	2	IPR017927
Domain	FAD_FR	DUOX2 NOS1	4.94e-03	19	104	2	PS51384
Domain	Riboflavin_synthase-like_b-brl	DUOX2 NOS1	4.94e-03	19	104	2	IPR017938
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	CEBPB NLRX1 TRMT1 REV3L WASHC2A TFE3 MAPK8IP3 PRR12 KMT2D TKFC SHANK2 DIAPH2 NINL MFN2 PDCD11 UBE3C SIPA1L2	4.78e-08	1105	107	17	35748872
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	SLAIN2 MRE11 CAAP1 GIPC2 CEBPB PPFIA1 DDX51 CEP164 INTS10 PRR12 SHANK2 SUN2 PWP2 PDCD11 ANKRD17 PARD3 TARBP2 MPP7	7.07e-07	1497	107	18	31527615
Pubmed	A role for mDia, a Rho-regulated actin nucleator, in tangential migration of interneuron precursors.	RELN DIAPH2 DIAPH3	6.10e-06	12	107	3	22246438
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	SLAIN2 MRE11 CAAP1 PPFIA1 REV3L INTS10 PPP2R5A SUN2 NEURL1 ANKRD17 PARD3 SIPA1L2 TARBP2 ZNF646	8.58e-06	1116	107	14	31753913
Pubmed	S6K2-mediated regulation of TRBP as a determinant of miRNA expression in human primary lymphatic endothelial cells.	RPS6KB2 TARBP2	9.38e-06	2	107	2	27407113
Pubmed	The coexpression of reelin and neuronal nitric oxide synthase in a subpopulation of dentate gyrus neurons is downregulated in heterozygous reeler mice.	RELN NOS1	9.38e-06	2	107	2	21331324
Pubmed	Overlapping roles of JIP3 and JIP4 in promoting axonal transport of lysosomes in human iPSC-derived neurons.	SPAG9 MAPK8IP3	9.38e-06	2	107	2	33788575
Pubmed	Knockdown of REV3 synergizes with ATR inhibition to promote apoptosis induced by cisplatin in lung cancer cells.	ATR REV3L	9.38e-06	2	107	2	28075014
Pubmed	Unexpected modes of PDZ domain scaffolding revealed by structure of nNOS-syntrophin complex.	NOS1 SNTA1	9.38e-06	2	107	2	10221915
Pubmed	Association of neuronal nitric oxide synthase (nNOS) with alpha1-syntrophin at the sarcolemma.	NOS1 SNTA1	9.38e-06	2	107	2	11747091
Pubmed	The MRE11 GAR motif regulates DNA double-strand break processing and ATR activation.	MRE11 ATR	9.38e-06	2	107	2	21826105
Pubmed	Golgi and sarcolemmal neuronal NOS differentially regulate contraction-induced fatigue and vasoconstriction in exercising mouse skeletal muscle.	NOS1 SNTA1	9.38e-06	2	107	2	20124730
Pubmed	Structural characterization of the RH1-LZI tandem of JIP3/4 highlights RH1 domains as a cytoskeletal motor-binding motif.	SPAG9 MAPK8IP3	9.38e-06	2	107	2	31690808
Pubmed	The Liprin homology domain is essential for the homomeric interaction of SYD-2/Liprin-α protein in presynaptic assembly.	PPFIA1 MAPK8IP3	9.38e-06	2	107	2	22072677
Pubmed	Vasomodulation by skeletal muscle-derived nitric oxide requires alpha-syntrophin-mediated sarcolemmal localization of neuronal Nitric oxide synthase.	NOS1 SNTA1	9.38e-06	2	107	2	12600881
Pubmed	Nuclear recruitment of neuronal nitric-oxide synthase by α-syntrophin is crucial for the induction of mitochondrial biogenesis.	NOS1 SNTA1	9.38e-06	2	107	2	24235139
Pubmed	alpha1-syntrophin gene disruption results in the absence of neuronal-type nitric-oxide synthase at the sarcolemma but does not induce muscle degeneration.	NOS1 SNTA1	9.38e-06	2	107	2	9890982
Pubmed	A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.	MRE11 PMPCB IFT172 PPFIA1 SH3GL1 RANBP6 SPAG9 ANKRD17 DIAPH3 UBE3C SIPA1L2 SNTA1 MPP7	9.61e-06	974	107	13	28675297
Pubmed	Comparative Application of BioID and TurboID for Protein-Proximity Biotinylation.	CPEB2 CEBPB PRR12 KMT2D TKFC SUN2 PDCD11 ANKRD17 CRTC2	1.24e-05	457	107	9	32344865
Pubmed	Transcription factor Foxp3 and its protein partners form a complex regulatory network.	HK2 ATR DHX37 DDX51 INTS10 PPP2R5A PWP2 ELF4	1.98e-05	370	107	8	22922362
Pubmed	Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV.	CAAP1 ATR PMPCB NLRX1 RANBP6 APOB SPAG9 TUT1 LRFN4 TKFC UBE3C TARBP2 PIGO	2.36e-05	1061	107	13	33845483
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	MRE11 CAAP1 ATR DDX51 SPAG9 HEXIM2 MAPK8IP3 EEF2 KMT2D ANKRD17 PARD3	2.76e-05	774	107	11	15302935
Pubmed	EGF-induced C/EBPβ participates in EMT by decreasing the expression of miR-203 in esophageal squamous cell carcinoma cells.	CEBPB EGF	2.81e-05	3	107	2	24994936
Pubmed	Development of serous ovarian cancer is associated with the expression of homologous recombination pathway proteins.	MRE11 ATR	2.81e-05	3	107	2	24752797
Pubmed	Cep164 is a mediator protein required for the maintenance of genomic stability through modulation of MDC1, RPA, and CHK1.	ATR CEP164	2.81e-05	3	107	2	18283122
Pubmed	Defects in neuromuscular junction structure in dystrophic muscle are corrected by expression of a NOS transgene in dystrophin-deficient muscles, but not in muscles lacking alpha- and beta1-syntrophins.	NOS1 SNTA1	2.81e-05	3	107	2	15238508
Pubmed	The scaffold protein JIP3 functions as a downstream effector of the small GTPase ARF6 to regulate neurite morphogenesis of cortical neurons.	SPAG9 MAPK8IP3	2.81e-05	3	107	2	20493856
Pubmed	JSAP1/JIP3 and JLP regulate kinesin-1-dependent axonal transport to prevent neuronal degeneration.	SPAG9 MAPK8IP3	2.81e-05	3	107	2	25571974
Pubmed	The alpha-syntrophin PH and PDZ domains scaffold acetylcholine receptors, utrophin, and neuronal nitric oxide synthase at the neuromuscular junction.	NOS1 SNTA1	2.81e-05	3	107	2	20720107
Pubmed	Rapid activation of ATR by ionizing radiation requires ATM and Mre11.	MRE11 ATR	2.81e-05	3	107	2	16431910
Pubmed	NO production results in suspension-induced muscle atrophy through dislocation of neuronal NOS.	NOS1 SNTA1	2.81e-05	3	107	2	17786240
Pubmed	Epidermal growth factor down-regulates the expression of human hepatic stimulator substance via CCAAT/enhancer-binding protein β in HepG2 cells.	CEBPB EGF	2.81e-05	3	107	2	20690902
Pubmed	Loss and gain of function of Grp75 or mitofusin 2 distinctly alter cholesterol metabolism, but all promote triglyceride accumulation in hepatocytes.	APOB MFN2	2.81e-05	3	107	2	34419589
Pubmed	Interplay between Porphyromonas gingivalis and EGF signalling in the regulation of CXCL14.	EGF PARD3	2.81e-05	3	107	2	29504253
Pubmed	JSAP1 and JLP are required for ARF6 localization to the midbody in cytokinesis.	SPAG9 MAPK8IP3	2.81e-05	3	107	2	25130574
Pubmed	TMED6-COG8 is a novel molecular marker of TFE3 translocation renal cell carcinoma.	TFE3 COG8	2.81e-05	3	107	2	26045774
Pubmed	Essential and nonredundant roles for Diaphanous formins in cortical microtubule capture and directed cell migration.	DIAPH2 DIAPH3	2.81e-05	3	107	2	24403606
Pubmed	Critical role of JSAP1 and JLP in axonal transport in the cerebellar Purkinje cells of mice.	SPAG9 MAPK8IP3	2.81e-05	3	107	2	26320416
Pubmed	A high-throughput approach for measuring temporal changes in the interactome.	MRE11 HK2 PPFIA1 SH3GL1 TRMT1 RANBP6 SPAG9 TUT1 TTC4 WASHC2A CUTC EEF2 RNF123 TKFC UBE3C	3.97e-05	1455	107	15	22863883
Pubmed	Mislocalization of the MRN complex prevents ATR signaling during adenovirus infection.	MRE11 ATR	5.60e-05	4	107	2	19197236
Pubmed	Novel roles of formin mDia2 in lamellipodia and filopodia formation in motile cells.	DIAPH2 DIAPH3	5.60e-05	4	107	2	18044991
Pubmed	mDia-interacting protein acts downstream of Rho-mDia and modifies Src activation and stress fiber formation.	DIAPH2 DIAPH3	5.60e-05	4	107	2	11509578
Pubmed	Syntrophin binds directly to multiple spectrin-like repeats in dystrophin and mediates binding of nNOS to repeats 16-17.	NOS1 SNTA1	5.60e-05	4	107	2	29790927
Pubmed	Loss of a Rho-regulated actin nucleator, mDia2, impairs cytokinesis during mouse fetal erythropoiesis.	DIAPH2 DIAPH3	5.60e-05	4	107	2	24239357
Pubmed	Interaction of nitric oxide synthase with the postsynaptic density protein PSD-95 and alpha1-syntrophin mediated by PDZ domains.	NOS1 SNTA1	5.60e-05	4	107	2	8625413
Pubmed	Syntrophin mutation associated with long QT syndrome through activation of the nNOS-SCN5A macromolecular complex.	NOS1 SNTA1	5.60e-05	4	107	2	18591664
Pubmed	GIPC gene family (Review).	GIPC2 GIPC3	5.60e-05	4	107	2	12011974
Pubmed	TFEB regulates lysosomal positioning by modulating TMEM55B expression and JIP4 recruitment to lysosomes.	SPAG9 TFE3	5.60e-05	4	107	2	29146937
Pubmed	Agonist-dependent interaction of the rat somatostatin receptor subtype 2 with cortactin-binding protein 1.	SHANK2 SNTA1	5.60e-05	4	107	2	10373412
Pubmed	Reelin controls position of autonomic neurons in the spinal cord.	RELN NOS1	5.60e-05	4	107	2	10880573
Pubmed	Physical interaction between the herpes simplex virus type 1 exonuclease, UL12, and the DNA double-strand break-sensing MRN complex.	MRE11 ATR	5.60e-05	4	107	2	20943970
Pubmed	EphA4-dependent axon retraction and midline localization of Ephrin-B3 are disrupted in the spinal cord of mice lacking mDia1 and mDia3 in combination.	DIAPH2 DIAPH3	5.60e-05	4	107	2	23890216
Pubmed	Kinesin-dependent axonal transport is mediated by the sunday driver (SYD) protein.	SPAG9 MAPK8IP3	5.60e-05	4	107	2	11106729
Pubmed	Rho activation of mDia formins is modulated by an interaction with inverted formin 2 (INF2).	DIAPH2 DIAPH3	5.60e-05	4	107	2	21278336
Pubmed	Migratory pathway of sympathetic preganglionic neurons in normal and reeler mutant mice.	RELN NOS1	5.60e-05	4	107	2	12687699
Pubmed	Bestrophin interacts physically and functionally with protein phosphatase 2A.	BEST1 PPP2R5A	5.60e-05	4	107	2	12058047
Pubmed	The sarcolemmal calcium pump, alpha-1 syntrophin, and neuronal nitric-oxide synthase are parts of a macromolecular protein complex.	NOS1 SNTA1	5.60e-05	4	107	2	16735509
Pubmed	Inactivation of the Nijmegen breakage syndrome gene leads to excess centrosome duplication via the ATR/BRCA1 pathway.	MRE11 ATR	9.32e-05	5	107	2	19244116
Pubmed	A molecular mechanism for LINC complex branching by structurally diverse SUN-KASH 6:6 assemblies.	KASH5 SUN2	9.32e-05	5	107	2	33393904
Pubmed	Identification and characterization of a 315-base pair enhancer, located more than 55 kilobases 5' of the apolipoprotein B gene, that confers expression in the intestine.	CEBPB APOB	9.32e-05	5	107	2	10859308
Pubmed	Dp71 gene disruption alters the composition of the dystrophin-associated protein complex and neuronal nitric oxide synthase expression in the hypothalamic supraoptic and paraventricular nuclei.	NOS1 SNTA1	9.32e-05	5	107	2	22493004
Pubmed	The basic cleft of RPA70N binds multiple checkpoint proteins, including RAD9, to regulate ATR signaling.	MRE11 ATR	9.32e-05	5	107	2	18936170
Pubmed	RhoD activated by fibroblast growth factor induces cytoneme-like cellular protrusions through mDia3C.	DIAPH2 DIAPH3	9.32e-05	5	107	2	23034183
Pubmed	Layer positioning of late-born cortical interneurons is dependent on Reelin but not p35 signaling.	RELN NOS1	9.32e-05	5	107	2	16452688
Pubmed	NOS1 mutations cause hypogonadotropic hypogonadism with sensory and cognitive deficits that can be reversed in infantile mice.	CEBPB NOS1	9.32e-05	5	107	2	36197968
Pubmed	Identification of proteins interacting with the rat somatostatin receptor subtype 2.	SHANK2 SNTA1	9.32e-05	5	107	2	11087996
Pubmed	Human transcription factor protein interaction networks.	MRE11 DHX37 TMED5 E2F3 SPAG9 WASHC2A TFE3 HEXIM2 PRR12 KMT2D MID1IP1 PDCD11 ANKRD17 ELF4	1.26e-04	1429	107	14	35140242
Pubmed	DNA damage signaling in hematopoietic cells: a role for Mre11 complex repair of topoisomerase lesions.	MRE11 ELF4	1.40e-04	6	107	2	18381424
Pubmed	EB1 and APC bind to mDia to stabilize microtubules downstream of Rho and promote cell migration.	DIAPH2 DIAPH3	1.40e-04	6	107	2	15311282
Pubmed	Migration of sympathetic preganglionic neurons in the spinal cord of a C3G-deficient mouse suggests that C3G acts in the reelin signaling pathway.	RELN NOS1	1.40e-04	6	107	2	22351125
Pubmed	Structural Analysis of Different LINC Complexes Reveals Distinct Binding Modes.	KASH5 SUN2	1.40e-04	6	107	2	33058875
Pubmed	Specificity of interactions between mDia isoforms and Rho proteins.	DIAPH2 DIAPH3	1.40e-04	6	107	2	18829452
Pubmed	TFE3 transcriptionally activates hepatic IRS-2, participates in insulin signaling and ameliorates diabetes.	HK2 TFE3	1.40e-04	6	107	2	16327801
Pubmed	LRRK2 and the stress response: interaction with MKKs and JNK-interacting proteins.	SPAG9 MAPK8IP3	1.40e-04	6	107	2	20173330
Pubmed	Host PDZ-containing proteins targeted by SARS-CoV-2.	GIPC2 PARD3 SIPA1L2	1.72e-04	35	107	3	33864728
Pubmed	The Mre11-Rad50-Nbs1 complex acts both upstream and downstream of ataxia telangiectasia mutated and Rad3-related protein (ATR) to regulate the S-phase checkpoint following UV treatment.	MRE11 ATR	1.95e-04	7	107	2	17526493
Pubmed	A microRNA switch regulates the rise in hypothalamic GnRH production before puberty.	CEBPB NOS1	1.95e-04	7	107	2	27135215
Pubmed	The GIPC1-Akt1 Pathway Is Required for the Specification of the Eye Field in Mouse Embryonic Stem Cells.	GIPC2 GIPC3	1.95e-04	7	107	2	26013465
Pubmed	RNF126-Mediated MRE11 Ubiquitination Activates the DNA Damage Response and Confers Resistance of Triple-Negative Breast Cancer to Radiotherapy.	MRE11 ATR	1.95e-04	7	107	2	36563124
Pubmed	The cellular prion protein colocalizes with the dystroglycan complex in the brain.	NOS1 SNTA1	1.95e-04	7	107	2	11032878
Pubmed	A High-Density Human Mitochondrial Proximity Interaction Network.	HK2 PMPCB TRMT1 RANBP6 SPAG9 TTC4 NBAS SUN2 PWP2 MFN2 PDCD11 UQCC1 DIAPH3 UBE3C	2.02e-04	1496	107	14	32877691
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	SLAIN2 E2F3 ACSBG1 NINL PDCD11 ANKRD17 CARNS1 ZNF646	2.37e-04	529	107	8	14621295
Pubmed	Artemis is a phosphorylation target of ATM and ATR and is involved in the G2/M DNA damage checkpoint response.	MRE11 ATR	2.59e-04	8	107	2	15456891
Pubmed	Identification of potential bladder cancer markers in urine by abundant-protein depletion coupled with quantitative proteomics.	APOB EGF	2.59e-04	8	107	2	23631828
Pubmed	Genes encoding alpha and beta subunits of Na,K-ATPase are located on three different chromosomes in the mouse.	CYP2A13 EGF	2.59e-04	8	107	2	2885848
Pubmed	Cbl-CIN85-endophilin complex mediates ligand-induced downregulation of EGF receptors.	SH3GL1 EGF	2.59e-04	8	107	2	11894095
Pubmed	Caveolin-3 deficiency causes muscle degeneration in mice.	NOS1 SNTA1	2.59e-04	8	107	2	11115849
Pubmed	Interaction of muscle and brain sodium channels with multiple members of the syntrophin family of dystrophin-associated proteins.	NOS1 SNTA1	2.59e-04	8	107	2	9412493
Pubmed	A Single Adaptable Cochaperone-Scaffold Complex Delivers Nascent Iron-Sulfur Clusters to Mammalian Respiratory Chain Complexes I-III.	HDHD3 HK2 NLRX1 TTC4 NBAS SUN2 PWP2 MFN2 TARBP2	2.76e-04	686	107	9	28380382
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	SLAIN2 MRE11 SH3GL1 SPAG9 KMT2D PDCD11 DIAPH3 PARD3	3.04e-04	549	107	8	38280479
Pubmed	HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.	MRE11 CAAP1 DHX37 PPFIA1 APOB HEXIM2 CUTC EEF2 TKFC PDCD11 ANKRD17 PARD3 TARBP2	3.05e-04	1371	107	13	36244648
Pubmed	The p300/YY1/miR-500a-5p/HDAC2 signalling axis regulates cell proliferation in human colorectal cancer.	SLAIN2 MRE11 EEF2 TKFC ANKRD17 CRTC2	3.30e-04	298	107	6	30737378
Pubmed	Unique requirement for Rb/E2F3 in neuronal migration: evidence for cell cycle-independent functions.	RELN E2F3	3.33e-04	9	107	2	17452454
Pubmed	Location of preganglionic neurons is independent of birthdate but is correlated to reelin-producing cells in the spinal cord.	RELN NOS1	3.33e-04	9	107	2	15236237
Pubmed	Maternal DHA intake in mice increased DHA metabolites in the pup brain and ameliorated MeHg-induced behavioral disorder.	CYP2A13 CYP2C19	3.33e-04	9	107	2	37838304
Pubmed	Layer acquisition by cortical GABAergic interneurons is independent of Reelin signaling.	RELN NOS1	3.33e-04	9	107	2	16807322
Pubmed	Proteolysis of MLL family proteins is essential for taspase1-orchestrated cell cycle progression.	E2F3 KMT2D	3.33e-04	9	107	2	16951254
Pubmed	Impaired OTUD7A-dependent Ankyrin regulation mediates neuronal dysfunction in mouse and human models of the 15q13.3 microdeletion syndrome.	SLITRK4 SPAG9 MAPK8IP3 SHANK2 NOS1	3.69e-04	197	107	5	36604605
Pubmed	A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.	MRE11 CAAP1 CCDC9B DHX37 PPFIA1 SH3GL1 WASHC2A ANKRD17 DIAPH3	4.08e-04	724	107	9	36232890
Pubmed	A proteomic analysis of ataxia telangiectasia-mutated (ATM)/ATM-Rad3-related (ATR) substrates identifies the ubiquitin-proteasome system as a regulator for DNA damage checkpoints.	ATR TAOK3	4.15e-04	10	107	2	17478428
Interaction	GYPA interactions	ATR NLRX1 COG8 TKFC PWP2 MFN2 SESN2 DIAPH3 UBE3C	3.20e-07	174	105	9	int:GYPA
Cytoband	11q13.2	RPS6KB2 LRFN4 SHANK2 CARNS1	4.60e-06	47	107	4	11q13.2
GeneFamily	PDZ domain containing	GIPC2 GIPC3 SHANK2 PARD3 SIPA1L2 NOS1 SNTA1 MPP7	3.67e-08	152	60	8	1220
GeneFamily	Ankyrin repeat domain containing	ASZ1 ANKMY1 SHANK2 ANKDD1B ANKRD17	1.24e-03	242	60	5	403
GeneFamily	Glycosyl transferases group 1 domain containing\|Phosphatidylinositol glycan anchor biosynthesis	PIGV PIGO	2.18e-03	21	60	2	680
GeneFamily	Sterile alpha motif domain containing	ASZ1 PPFIA1 SHANK2	3.12e-03	88	60	3	760
Disease	Alzheimer's disease (is_marker_for)	MRE11 RELN CEBPB ATR EEF2 EGF MFN2 NOS1	3.46e-06	257	103	8	DOID:10652 (is_marker_for)
Disease	autosomal dominant auditory neuropathy 1 (implicated_via_orthology)	DIAPH2 DIAPH3	3.61e-05	3	103	2	DOID:0060690 (implicated_via_orthology)
Disease	Global developmental delay	TRMT1 MAPK8IP3 PRR12 NBAS TKFC	1.06e-04	133	103	5	C0557874
Disease	fatty acid measurement	BEST1 PMPCB RTN4RL1 CRTAC1 E2F3 APOB INTS10 FERMT3	1.49e-04	436	103	8	EFO_0005110
Disease	Hyperphosphatasia-intellectual disability syndrome	PIGV PIGO	1.79e-04	6	103	2	cv:C1855923
Disease	Hyperphosphatasia with Mental Retardation	PIGV PIGO	2.51e-04	7	103	2	C1855923
Disease	hemoglobin A1 measurement	MGAM CYP2C19 GIPC2 NLRX1 TAOK3 EGF ELF4 UBE3C	4.85e-04	520	103	8	EFO_0007629
Disease	Microphthalmos	BEST1 KMT2D	6.50e-04	11	103	2	C0026010
Disease	polyunsaturated fatty acids to monounsaturated fatty acids ratio	BEST1 APOB INTS10	7.62e-04	51	103	3	EFO_0022302
Disease	gallbladder cancer (is_implicated_in)	APOB EGF	9.18e-04	13	103	2	DOID:3121 (is_implicated_in)
Disease	esterified cholesterol measurement, low density lipoprotein cholesterol measurement	APOB ANKRD17	1.07e-03	14	103	2	EFO_0004611, EFO_0008589
Disease	pancreas fat measurement	NHLRC1 CEBPB	1.23e-03	15	103	2	EFO_0600049
Disease	sickle cell anemia (is_implicated_in)	CYP2C19 APOB	1.40e-03	16	103	2	DOID:10923 (is_implicated_in)
Disease	Left Ventricle Remodeling	MFN2 NOS1	2.43e-03	21	103	2	C0600520
Disease	Ventricular Remodeling	MFN2 NOS1	2.43e-03	21	103	2	C0600519
Disease	activities of daily living score measurement	RTN4RL1 NOS1	2.43e-03	21	103	2	EFO_0008451
Disease	monounsaturated fatty acids; 16:1, 18:1 measurement	BEST1 APOB INTS10	2.60e-03	78	103	3	EFO_0022187
Disease	free cholesterol in large HDL measurement	APOB INTS10 ANKDD1B	2.69e-03	79	103	3	EFO_0022157
Disease	triglyceride measurement, low density lipoprotein cholesterol measurement	CRTAC1 E2F3 APOB INTS10	2.77e-03	166	103	4	EFO_0004530, EFO_0004611
Disease	nephrotic syndrome (biomarker_via_orthology)	APOB NOS1	3.17e-03	24	103	2	DOID:1184 (biomarker_via_orthology)
Disease	nicotine dependence symptom count	SLAIN2 CRTAC1 INTS10 SESN2 PARD3	3.29e-03	285	103	5	EFO_0009262
Disease	squamous cell lung carcinoma, family history of lung cancer	MYO1G NBAS UBE3C	3.32e-03	85	103	3	EFO_0000708, EFO_0006953
Disease	breast cancer (implicated_via_orthology)	MRE11 ATR	3.44e-03	25	103	2	DOID:1612 (implicated_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
EGTEHDVDLVLFGGR	CARNS1	606	A5YM72
LLGGQLGLEDFIFAH	GIPC2	96	Q8TF65
LLGGQIGLEDFIFAH	GIPC3	91	Q8TF64
DEEDAHAGIIGRFLG	BEST1	381	O76090
LAEHSDLEEGGLDLT	CAAP1	116	Q9H8G2
LLQAGADLEHESEGG	ANKRD17	616	O75179
FGHEGLGLLLDELEK	DIAPH2	201	O60879
VESFGHEGLGLLLDI	DIAPH3	211	Q9NSV4
FGDLEVFLHGLGLEH	ASZ1	276	Q8WWH4
FEGFVHLEELDLGDN	RTN4RL1	96	Q86UN2
GLGEHLERGEDAAAG	NAP1L2	26	Q9ULW6
LEGILGGLGLREHFD	HDHD3	141	Q9BSH5
EAAHLLLLTALDGGD	PCDHGA11	206	Q9Y5H2
HGVGLGEALLEAETI	INTS10	146	Q9NVR2
HGGLELEEETAFQGA	KASH5	111	Q8N6L0
SGLIGDVDEGADLLG	SPAG9	391	O60271
EDEGLGVDLSFIGSH	GDAP2	271	Q9NXN4
LAAAGGVSHDELLDL	PMPCB	241	O75439
GDLVAGLSHLEELDL	TCTE1	231	Q5JU00
ILVDLGHLEGADAGE	MID1IP1	126	Q9NPA3
LADGTLAIFHRGEDG	MAPK8IP3	1016	Q9UPT6
GGHVELEEELLDGGL	NUDT17	126	P0C025
GLELDDVHNGIITDG	ELF4	51	Q99607
LLLGDDGHVKIADFG	CAMKK1	281	Q8N5S9
GLEEDGSAHGVLLLN	MGAM	2071	O43451
ESERLLSIGEIFGHG	CCDC190	266	Q86UF4
QLELLLGGLLESHGD	DUOX2	481	Q9NRD8
EHGEFLALDLGGTNF	HK2	76	P52789
DHGGTFCLGELVELA	CCDC9B	151	Q6ZUT6
LGLETDGEELAGAIA	GHDC	211	Q8N2G8
GAADRSGLIHVGDEL	MPP7	171	Q5T2T1
ETDLYRGIGGHLDSL	COG8	331	Q96MW5
GVHGALLALDETFDF	PPFIA1	1076	Q13136
RHLLFGDLLEDVGAA	LKAAEAR1	61	Q8TD35
HLSLLHTGLGDEGLE	NLRX1	811	Q86UT6
HTGLGDEGLELLAAQ	NLRX1	816	Q86UT6
EAGHEAEAGSLLLAV	NBAS	2336	A2RRP1
VEGTDGHEAFLLTEG	MFN2	136	O95140
LEGDGEQGEVLISLH	RELN	46	P78509
AIEEGTLDGLDHSDF	IFT172	1606	Q9UG01
GHAVDTLLEELGGER	NOS1	901	P29475
GEELGFASLHDLQLL	APOB	781	P04114
LGLGDRHGENILFDS	ATR	2471	Q13535
SVLDDLLYAVGGHDG	KLHL20	361	Q9Y2M5
EEAGFLIDALRGTHG	CYP2A13	151	Q16696
ALIDLGEEFSGRGHF	CYP2C19	86	P33261
LELGESGHQYLSDGL	E2F3	136	O00716
IDDGLLDDGHSDQVG	CPEB2	296	Q7Z5Q1
LALDGHQLLAGGEVD	EGF	781	P01133
LAHRGLEDTDGDGDS	DDX51	456	Q8N8A6
FEVSAAGLELGLGLE	CRTC2	641	Q53ET0
GELGSIGDHERAIDF	CEBPB	61	P17676
LHTGDAGRLDADGFL	ACSBG1	546	Q96GR2
AGDVDGVRLLLEHGA	ANKMY1	556	Q9P2S6
ADGLVFGALTEDGHI	CUTC	111	Q9NTM9
DFDGDGMLDLILSHG	CRTAC1	411	Q9NQ79
SGEHIIAGAGELHLE	EEF2	541	P13639
GALDSDLDLDLGDGG	DHX37	561	Q8IY37
AGSLHLLDVDFAEGV	NHLRC1	236	Q6VVB1
IEGGAFDGLAELRHL	NRROS	196	Q86YC3
LEHGDGGILDLDDIL	PARD3	51	Q8TEW0
DFTDFEGLDLLHLGS	SLITRK4	396	Q8IW52
EGAESLEQHLGLEAL	SESN2	56	P58004
EEGLHVLEGLAASGL	TRMT1	151	Q9NXH9
LDFGGAEGEIQLDLH	SNTA1	466	Q13424
SLLAAGEGGLLDEVE	SLAIN2	96	Q9P270
HGSLYLDNLESLGGE	TMEM225B	191	P0DP42
LSGGELFTHLEREGI	RPS6KB2	151	Q9UBS0
SHSEDEDLAGAVGGL	HEXIM2	51	Q96MH2
ELGDFAALLHAGLSV	SLC39A4	541	Q6P5W5
FEGLDSDEELGLLCH	SIPA1L2	1586	Q9P2F8
EELFIGLHEIGHGSF	TAOK3	21	Q9H2K8
LLTREGVGHDEAGEA	IQANK1	161	A8MXQ7
FGLGGALEAAESEGL	PRR12	1341	Q9ULL5
ATGCLLDDGLEGLFE	SERTAD1	161	Q9UHV2
EVDFILLGGDLFHEN	MRE11	51	P49959
EAEAELSGELSGLGA	NINL	736	Q9Y2I6
GCLNDEHLEELGGIL	RANBP6	791	O60518
AFLSTDLGDEDVGLG	SHANK2	1101	Q9UPX8
EHFNGVAELLEILGS	PPP2R5A	241	Q15172
GLGEEDTAVAGHELL	ANKDD1B	51	A6NHY2
LHLDIGALGGDFEYE	CEP164	241	Q9UPV0
GHRLELSDGDLLTFG	TCF19	91	Q9Y242
FVDQLVEGLLGGLSH	PIGV	51	Q9NUD9
SLEDHGYLVDIGVDG	PDCD11	196	Q14690
NDGELGFHEGDVITL	SH3GL1	321	Q99961
SEEFSAGGELGLELA	TTBK1	951	Q5TCY1
DGAGLDIDFHLASPE	TMED5	66	Q9Y3A6
GDILGLVVNADGELH	NEURL1	396	O76050
GGLSHEDTLALLEGL	SUN2	321	Q9UH99
GDLGDPFHLGLEDIL	TFE3	511	P19532
DEALVHLLAGLESDG	REV3L	411	O60673
EASEDDSLHLLGGGG	PWP2	896	Q15269
DSLHLLGGGGRDSEE	PWP2	901	Q15269
LDHTGGFEGLLLVDD	RNF123	96	Q5XPI4
DVHGCDLDLFLDLGD	TUT1	211	Q9H6E5
GLLFEDAESLERHGL	ZNF646	581	O15015
ELDEDLFLQLTGGHE	FERMT3	651	Q86UX7
AILGYDEGILSDDHG	UQCC1	211	Q9NVA1
DEGILSDDHGLAAAL	UQCC1	216	Q9NVA1
GHSRGEADLFDSGDI	WASHC2A	1121	Q641Q2
HGGDSELEVSAALFL	PIGO	286	Q8TEQ8
DDDHFSIGVGSRLDG	TARBP2	241	Q15633
ADEVELGLGIHGEAG	TKFC	211	Q3LXA3
EDSASEGLGELFLDG	TTC4	241	O95801
EGLGELFLDGLSTEN	TTC4	246	O95801
LLNAHGLDEAGIDGG	UBE3C	756	Q15386
HLGLGVDVAKGDDEL	KMT2D	3011	O14686
AFGDLESLRSLHLDG	LRFN4	91	Q6PJG9
HLGNIEFVETEEGGL	MYO1G	281	B0I1T2
SLGELQELFSGIDGH	NECAB3	71	Q96P71