Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	low voltage-gated calcium channel activity	CACNA1I CACNA1G	3.32e-05	3	67	2	GO:0008332
GeneOntologyBiologicalProcess	regulation of regulated secretory pathway	ADRA2A PPFIA2 GAB4 CACNA1I CACNA1G BCL2L1 BCR	8.70e-07	165	65	7	GO:1903305
GeneOntologyBiologicalProcess	regulation of exocytosis	ADRA2A PPFIA2 GAB4 CACNA1I CACNA1G BCL2L1 BCR	8.56e-06	233	65	7	GO:0017157
GeneOntologyBiologicalProcess	regulated exocytosis	ADRA2A PPFIA2 GAB4 CACNA1I CACNA1G BCL2L1 BCR	3.58e-05	291	65	7	GO:0045055
GeneOntologyBiologicalProcess	positive regulation of regulated secretory pathway	GAB4 CACNA1I CACNA1G BCL2L1	5.59e-05	66	65	4	GO:1903307
GeneOntologyBiologicalProcess	positive regulation of cell population proliferation	ERBB3 PRRX1 ADRA2A TJP1 GAB4 HLX MARCHF7 BCL2L1 ST8SIA1 DMD MMP9 PHIP PRRX2	7.27e-05	1190	65	13	GO:0008284
Domain	-	ALX3 PRRX1 DUXA CERS3 HLX SIX5 LHX3 SIX3 DNAJC2 PRRX2	6.31e-08	283	67	10	1.10.10.60
Domain	Homeobox	ALX3 PRRX1 DUXA CERS3 HLX SIX5 LHX3 SIX3 PRRX2	1.48e-07	234	67	9	PF00046
Domain	HOMEOBOX_1	ALX3 PRRX1 DUXA CERS3 HLX SIX5 LHX3 SIX3 PRRX2	1.59e-07	236	67	9	PS00027
Domain	HOX	ALX3 PRRX1 DUXA CERS3 HLX SIX5 LHX3 SIX3 PRRX2	1.65e-07	237	67	9	SM00389
Domain	HOMEOBOX_2	ALX3 PRRX1 DUXA CERS3 HLX SIX5 LHX3 SIX3 PRRX2	1.77e-07	239	67	9	PS50071
Domain	Homeobox_dom	ALX3 PRRX1 DUXA CERS3 HLX SIX5 LHX3 SIX3 PRRX2	1.77e-07	239	67	9	IPR001356
Domain	Homeodomain-like	ALX3 PRRX1 DUXA CERS3 HLX SIX5 LHX3 SIX3 DNAJC2 PRRX2	2.78e-07	332	67	10	IPR009057
Domain	VDCC_T_a1	CACNA1I CACNA1G	3.79e-05	3	67	2	IPR005445
Domain	Homeobox_CS	ALX3 PRRX1 HLX SIX5 LHX3 PRRX2	5.42e-05	186	67	6	IPR017970
Domain	HTH_motif	DUXA HLX SIX3 PRRX2	1.10e-04	69	67	4	IPR000047
Domain	SIX1_SD	SIX5 SIX3	2.63e-04	7	67	2	PF16878
Domain	SIX1_SD	SIX5 SIX3	2.63e-04	7	67	2	IPR031701
Domain	VDCCAlpha1	CACNA1I CACNA1G	5.60e-04	10	67	2	IPR002077
Domain	Pept_M10A_Zn_BS	MMP9 MMP11	1.29e-03	15	67	2	IPR021158
Domain	OAR	PRRX1 PRRX2	1.29e-03	15	67	2	PF03826
Domain	OAR	PRRX1 PRRX2	1.47e-03	16	67	2	PS50803
Domain	OAR_dom	PRRX1 PRRX2	1.47e-03	16	67	2	IPR003654
Domain	Hemopexin_CS	MMP9 MMP11	1.67e-03	17	67	2	IPR018486
Domain	Hemopexin-like_dom	MMP9 MMP11	3.06e-03	23	67	2	IPR000585
Domain	Hemopexin-like_repeat	MMP9 MMP11	3.06e-03	23	67	2	IPR018487
Domain	M10A_MMP	MMP9 MMP11	3.06e-03	23	67	2	IPR033739
Domain	Hemopexin	MMP9 MMP11	3.06e-03	23	67	2	PF00045
Domain	HEMOPEXIN	MMP9 MMP11	3.06e-03	23	67	2	PS00024
Domain	-	MMP9 MMP11	3.06e-03	23	67	2	2.110.10.10
Domain	HEMOPEXIN_2	MMP9 MMP11	3.06e-03	23	67	2	PS51642
Domain	HX	MMP9 MMP11	3.06e-03	23	67	2	SM00120
Domain	Pept_M10A	MMP9 MMP11	3.06e-03	23	67	2	IPR021190
Domain	PH	PLEKHG4 ELMO2 GAB4 BCR MPRIP	3.21e-03	278	67	5	SM00233
Domain	PH_DOMAIN	PLEKHG4 ELMO2 GAB4 BCR MPRIP	3.26e-03	279	67	5	PS50003
Domain	PH_domain	PLEKHG4 ELMO2 GAB4 BCR MPRIP	3.31e-03	280	67	5	IPR001849
Domain	Peptidase_M10	MMP9 MMP11	3.33e-03	24	67	2	PF00413
Domain	ZnMc	MMP9 MMP11	4.84e-03	29	67	2	SM00235
Domain	Peptidase_Metallo	MMP9 MMP11	4.84e-03	29	67	2	IPR006026
Domain	ZINC_PROTEASE	MBTPS2 MMP9 MMP11	5.26e-03	98	67	3	PS00142
Pubmed	Pax6 regulates craniofacial form through its control of an essential cephalic ectodermal patterning center.	ALX3 PRRX1 SIX3 PRRX2	1.01e-07	22	69	4	21309073
Pubmed	Expression patterns of group-I aristaless-related genes during craniofacial and limb development.	ALX3 PRRX1 PRRX2	1.49e-07	6	69	3	11520673
Pubmed	Prx1 and Prx2 are upstream regulators of sonic hedgehog and control cell proliferation during mandibular arch morphogenesis.	ALX3 PRRX1 PRRX2	2.60e-07	7	69	3	11532916
Pubmed	Cav3.2 T-type calcium channel is required for the NFAT-dependent Sox9 expression in tracheal cartilage.	PRRX1 CACNA1I CACNA1G	8.88e-07	10	69	3	24778262
Pubmed	The Prx1 homeobox gene is critical for molar tooth morphogenesis.	PRRX1 PRRX2	3.88e-06	2	69	2	16998126
Pubmed	The relationship between MMP9 and ADRA2A gene polymorphisms and mothers-newborns' nutritional status: an exploratory path model (STROBE compliant article).	ADRA2A MMP9	3.88e-06	2	69	2	30791043
Pubmed	Human PRRX1 and PRRX2 genes: cloning, expression, genomic localization, and exclusion as disease genes for Nager syndrome.	PRRX1 PRRX2	3.88e-06	2	69	2	11063257
Pubmed	Matrix metalloproteinase-9 inhibition ameliorates pathogenesis and improves skeletal muscle regeneration in muscular dystrophy.	DMD MMP9	3.88e-06	2	69	2	19401296
Pubmed	Negative regulation of TGFβ signaling by the kinase LKB1 and the scaffolding protein LIP1.	STK11 STK11IP	3.88e-06	2	69	2	20974850
Pubmed	Contribution of postsynaptic T-type calcium channels to parallel fibre-Purkinje cell synaptic responses.	CACNA1I CACNA1G	3.88e-06	2	69	2	26627919
Pubmed	Dystrophin and metalloproteinase 9 in myocardial ischemia: A post-mortem immunohistochemical study.	DMD MMP9	3.88e-06	2	69	2	34332258
Pubmed	Differential roles of MMP-9 in early and late stages of dystrophic muscles in a mouse model of Duchenne muscular dystrophy.	DMD MMP9	3.88e-06	2	69	2	26170062
Pubmed	Investigation of Prx1 protein expression provides evidence for conservation of cardiac-specific posttranscriptional regulation in vertebrates.	PRRX1 PRRX2	3.88e-06	2	69	2	11747080
Pubmed	Loss of function of the Prx1 and Prx2 homeobox genes alters architecture of the great elastic arteries and ductus arteriosus.	PRRX1 PRRX2	3.88e-06	2	69	2	10664157
Pubmed	Identification of a prx1 limb enhancer.	PRRX1 PRRX2	3.88e-06	2	69	2	10748458
Pubmed	Elevated levels of active matrix metalloproteinase-9 cause hypertrophy in skeletal muscle of normal and dystrophin-deficient mdx mice.	DMD MMP9	3.88e-06	2	69	2	21846793
Pubmed	LKB1 signaling is altered in skeletal muscle of a Duchenne muscular dystrophy mouse model.	STK11 DMD	3.88e-06	2	69	2	37427454
Pubmed	Comparative analysis of Prx1 and Prx2 expression in mice provides evidence for incomplete compensation.	PRRX1 PRRX2	3.88e-06	2	69	2	11748565
Pubmed	Dcp2 decapping protein modulates mRNA stability of the critical interferon regulatory factor (IRF) IRF-7.	DCP2 IRF7	3.88e-06	2	69	2	22252322
Pubmed	Differential expression of Prx I and II in mouse testis and their up-regulation by radiation.	PRRX1 PRRX2	3.88e-06	2	69	2	12163022
Pubmed	The LIM-homeodomain protein Lhx2 is required for complete development of mouse olfactory sensory neurons.	ALX3 PRRX1 PRRX2	8.32e-06	20	69	3	15173589
Pubmed	Ethanol inhibition of a T-type Ca²+ channel through activity of protein kinase C.	CACNA1I CACNA1G	1.16e-05	3	69	2	23488970
Pubmed	Matrix metalloproteinase-9 inhibition improves proliferation and engraftment of myogenic cells in dystrophic muscle of mdx mice.	DMD MMP9	1.16e-05	3	69	2	23977226
Pubmed	Identification of the t-type calcium channel (Ca(v)3.1d) in developing mouse heart.	CACNA1I CACNA1G	1.16e-05	3	69	2	11230107
Pubmed	Increased matrix-metalloproteinase-2 and matrix-metalloproteinase-9 expression in the brain of dystrophic mdx mouse.	DMD MMP9	1.16e-05	3	69	2	16650610
Pubmed	LIP1, a cytoplasmic protein functionally linked to the Peutz-Jeghers syndrome kinase LKB1.	STK11 STK11IP	1.16e-05	3	69	2	11741830
Pubmed	Homeostatic plasticity and burst activity are mediated by hyperpolarization-activated cation currents and T-type calcium channels in neuronal cultures.	CACNA1I CACNA1G	1.16e-05	3	69	2	33547341
Pubmed	Calmodulin regulates Cav3 T-type channels at their gating brake.	CACNA1I CACNA1G	1.16e-05	3	69	2	28972185
Pubmed	Low Six4 and Six5 gene dosage improves dystrophic phenotype and prolongs life span of mdx mice.	SIX5 DMD	1.16e-05	3	69	2	27224259
Pubmed	Growth differentiation factor-15 promotes glutamate release in medial prefrontal cortex of mice through upregulation of T-type calcium channels.	CACNA1I CACNA1G	1.16e-05	3	69	2	27353765
Pubmed	Alpha(1H) mRNA in single skeletal muscle fibres accounts for T-type calcium current transient expression during fetal development in mice.	CACNA1I CACNA1G	1.16e-05	3	69	2	11897840
Pubmed	Osteopontin-stimulated expression of matrix metalloproteinase-9 causes cardiomyopathy in the mdx model of Duchenne muscular dystrophy.	DMD MMP9	1.16e-05	3	69	2	21810612
Pubmed	RAIDD Mediates TLR3 and IRF7 Driven Type I Interferon Production.	CRADD IRF7	1.16e-05	3	69	2	27606466
Pubmed	Expression of matrix metalloproteinases 2 and 9 in regenerating skeletal muscle: a study in experimentally injured and mdx muscles.	DMD MMP9	1.16e-05	3	69	2	9882504
Pubmed	T-type channels: release a brake, engage a gear.	CACNA1I CACNA1G	1.16e-05	3	69	2	26488564
Pubmed	Differential interactions of Na+ channel toxins with T-type Ca2+ channels.	CACNA1I CACNA1G	1.16e-05	3	69	2	18591418
Pubmed	Prognostic relevance of a T-type calcium channels gene signature in solid tumours: A correlation ready for clinical validation.	CACNA1I CACNA1G	1.16e-05	3	69	2	28846697
Pubmed	Global genetic deletion of CaV3.3 channels facilitates anaesthetic induction and enhances isoflurane-sparing effects of T-type calcium channel blockers.	CACNA1I CACNA1G	1.16e-05	3	69	2	33299036
Pubmed	Specific contribution of human T-type calcium channel isotypes (alpha(1G), alpha(1H) and alpha(1I)) to neuronal excitability.	CACNA1I CACNA1G	1.16e-05	3	69	2	11927664
Pubmed	Dominant negative form of alpha4 inhibits the BCR crosslinking-induced phosphorylation of Bcl-xL and apoptosis in an immature B cell line WEHI-231.	BCL2L1 BCR	1.16e-05	3	69	2	25876659
Pubmed	HIV-1 Tat-induced cerebrovascular toxicity is enhanced in mice with amyloid deposits.	TJP1 MMP9	1.16e-05	3	69	2	21764480
Pubmed	Effects of omega-3 on matrix metalloproteinase-9, myoblast transplantation and satellite cell activation in dystrophin-deficient muscle fibers.	DMD MMP9	1.16e-05	3	69	2	28623422
Pubmed	A census of human transcription factors: function, expression and evolution.	ALX3 PRRX1 CERS3 HLX SIX5 IRF7 LHX3 SIX3 DNAJC2 PRRX2	1.18e-05	908	69	10	19274049
Pubmed	Angiopoietin-2 facilitates vascular endothelial growth factor-induced angiogenesis in the mature mouse brain.	TJP1 MMP9	2.32e-05	4	69	2	15947259
Pubmed	Altered blood-brain barrier development in dystrophic MDX mice.	TJP1 DMD	2.32e-05	4	69	2	15120852
Pubmed	Pharmacogenetics of antiepileptic drug efficacy in childhood absence epilepsy.	CACNA1I CACNA1G	2.32e-05	4	69	2	28165634
Pubmed	Severe alterations of endothelial and glial cells in the blood-brain barrier of dystrophic mdx mice.	TJP1 DMD	2.32e-05	4	69	2	12673830
Pubmed	Spp1 (osteopontin) promotes TGFβ processing in fibroblasts of dystrophin-deficient muscles through matrix metalloproteinases.	DMD MMP9	2.32e-05	4	69	2	31411676
Pubmed	Expression patterns of the paired-related homeobox genes MHox/Prx1 and S8/Prx2 suggest roles in development of the heart and the forebrain.	PRRX1 PRRX2	2.32e-05	4	69	2	7577675
Pubmed	Motor protein Myo1c is a podocyte protein that facilitates the transport of slit diaphragm protein Neph1 to the podocyte membrane.	MYO1C TJP1	2.32e-05	4	69	2	21402783
Pubmed	ALS/FTD-causing mutation in cyclin F causes the dysregulation of SFPQ.	CCDC8 GATAD2A MYO1C NOL6 MARCHF7 ZNF598 DNAJC2 MPRIP	3.28e-05	624	69	8	33729478
Pubmed	Tissue and developmental distribution of Six family gene products.	SIX5 SIX3	3.86e-05	5	69	2	9551859
Pubmed	Identification and expression of six family genes in mouse retina.	SIX5 SIX3	3.86e-05	5	69	2	8814301
Pubmed	Mechanism of blood-retinal barrier breakdown induced by HIV-1 (Review).	TJP1 MMP9	3.86e-05	5	69	2	24660027
Pubmed	Matrix metalloproteinase-2 and -9 secreted by leukemic cells increase the permeability of blood-brain barrier by disrupting tight junction proteins.	TJP1 MMP9	3.86e-05	5	69	2	21857898
Pubmed	prx-1 functions cooperatively with another paired-related homeobox gene, prx-2, to maintain cell fates within the craniofacial mesenchyme.	PRRX1 PRRX2	3.86e-05	5	69	2	9876178
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	CCDC8 MAST4 TJP1 ELMO2 DCP2 ANKRD11 ZNF598 BCR MPRIP	5.03e-05	861	69	9	36931259
Pubmed	Expression of myogenin during embryogenesis is controlled by Six/sine oculis homeoproteins through a conserved MEF3 binding site.	SIX5 SIX3	5.79e-05	6	69	2	9826681
Pubmed	Pax3 is required for cardiac neural crest migration in the mouse: evidence from the splotch (Sp2H) mutant.	PRRX1 PRRX2	5.79e-05	6	69	2	9053326
Pubmed	microRNA-875-5p plays critical role for mesenchymal condensation in epithelial-mesenchymal interaction during tooth development.	PRRX1 PRRX2	5.79e-05	6	69	2	32188878
Pubmed	Mouse Alx3: an aristaless-like homeobox gene expressed during embryogenesis in ectomesenchyme and lateral plate mesoderm.	ALX3 PRRX2	5.79e-05	6	69	2	9676189
Pubmed	A right-handed signalling pathway drives heart looping in vertebrates.	PRRX1 PRRX2	5.79e-05	6	69	2	28880281
Pubmed	Small mammalian animal models of heart disease.	STK11 DMD	5.79e-05	6	69	2	27679742
Pubmed	Characterization of the Six1 homeobox gene in normal mammary gland morphogenesis.	SIX5 SIX3	5.79e-05	6	69	2	20074369
Pubmed	The expression profile and clinic significance of the SIX family in non-small cell lung cancer.	SIX5 SIX3	5.79e-05	6	69	2	27821176
Pubmed	Dynamic expression of Six family genes in the dental mesenchyme and the epithelial ameloblast stem/progenitor cells during murine tooth development.	SIX5 SIX3	5.79e-05	6	69	2	19900183
Pubmed	Matrix metalloproteinase activity in pediatric acute lung injury.	MMP9 MMP11	5.79e-05	6	69	2	19159011
Pubmed	The apical ectodermal ridge of the mouse model of ectrodactyly Dlx5;Dlx6-/- shows altered stratification and cell polarity, which are restored by exogenous Wnt5a ligand.	ALX3 PRRX1 TJP1	7.55e-05	41	69	3	26685160
Pubmed	Prx1 and Prx2 in skeletogenesis: roles in the craniofacial region, inner ear and limbs.	PRRX1 PRRX2	8.09e-05	7	69	2	9729491
Pubmed	Expression of matrix metalloproteinases during murine chorioallantoic placenta maturation.	MMP9 MMP11	8.09e-05	7	69	2	10090151
Pubmed	Breaking down the barrier: the effects of HIV-1 on the blood-brain barrier.	TJP1 MMP9	8.09e-05	7	69	2	21641584
Pubmed	Mammalian APE1 controls miRNA processing and its interactome is linked to cancer RNA metabolism.	ACP7 CLCN3 ERGIC3 MYO1C PLEKHG4 LARS1 ZNF598 USP19 DNMT3B	8.70e-05	925	69	9	28986522
Pubmed	Evolutionary insights into T-type Ca2+ channel structure, function, and ion selectivity from the Trichoplax adhaerens homologue.	CACNA1I CACNA1G	1.08e-04	8	69	2	28330839
Pubmed	HIV-1 gp120 and drugs of abuse: interactions in the central nervous system.	TJP1 MMP9	1.08e-04	8	69	2	22591361
Pubmed	Neuroepithelial progenitors generate and propagate non-neuronal action potentials across the spinal cord.	CACNA1I CACNA1G	1.08e-04	8	69	2	34478646
Pubmed	L-arginine decreases inflammation and modulates the nuclear factor-kappaB/matrix metalloproteinase cascade in mdx muscle fibers.	DMD MMP9	1.08e-04	8	69	2	18458097
Pubmed	Expression and function of matrix metalloproteinases and their inhibitors at the maternal-embryonic boundary during mouse embryo implantation.	MMP9 MMP11	1.08e-04	8	69	2	8674412
Pubmed	Intracellular calcium plays an essential role in cardiac development.	CACNA1I CACNA1G	1.08e-04	8	69	2	12761855
Pubmed	Male germ cells require polyenoic sphingolipids with complex glycosylation for completion of meiosis: a link to ceramide synthase-3.	TJP1 CERS3	1.38e-04	9	69	2	18308723
Pubmed	International Union of Pharmacology. XLVIII. Nomenclature and structure-function relationships of voltage-gated calcium channels.	CACNA1I CACNA1G	1.38e-04	9	69	2	16382099
Pubmed	exma: an X-linked insertional mutation that disrupts forebrain and eye development.	DMD SIX3	1.38e-04	9	69	2	11956759
Pubmed	Discovering human diabetes-risk gene function with genetics and physiological assays.	ADRA2A SIX3	1.38e-04	9	69	2	30242153
Pubmed	The Src homology and collagen A (ShcA) adaptor protein is required for the spatial organization of the costamere/Z-disk network during heart development.	ERBB3 DMD	1.38e-04	9	69	2	25488665
Pubmed	Pleiotropic effects in Eya3 knockout mice.	SIX5 SIX3	1.38e-04	9	69	2	19102749
Pubmed	Matrix metalloproteinases regulate morphogenesis, migration and remodeling of epithelium, tongue skeletal muscle and cartilage in the mandibular arch.	MMP9 MMP11	1.38e-04	9	69	2	9108368
Pubmed	Stat5 regulates cellular iron uptake of erythroid cells via IRP-2 and TfR-1.	IREB2 BCL2L1	1.73e-04	10	69	2	18694996
Pubmed	The murine fork head gene Foxn2 is expressed in craniofacial, limb, CNS and somitic tissues during embryogenesis.	PRRX1 PRRX2	1.73e-04	10	69	2	12351180
Pubmed	Paired-related homeobox genes cooperate in handplate and hindlimb zeugopod morphogenesis.	PRRX1 PRRX2	1.73e-04	10	69	2	9882503
Pubmed	Gata2 is required for the development of inner ear semicircular ducts and the surrounding perilymphatic space.	BCL2L1 PRRX2	1.73e-04	10	69	2	20652952
Pubmed	Somatic mutations in epidermal growth factor receptor signaling pathway genes in non-small cell lung cancers.	STK11 ERBB3	1.73e-04	10	69	2	20881644
Pubmed	Screening large numbers of expression patterns of transcription factors in late stages of the mouse thymus.	ALX3 PRRX1 SIX5 LHX3 SIX3	1.80e-04	263	69	5	20932939
Pubmed	Lack of pendrin expression leads to deafness and expansion of the endolymphatic compartment in inner ears of Foxi1 null mutant mice.	ERBB3 TJP1	2.11e-04	11	69	2	12642503
Pubmed	HIV-1 gp120 Glycoprotein Interacting with Dendritic Cell-specific Intercellular Adhesion Molecule 3-grabbing Non-integrin (DC-SIGN) Down-Regulates Tight Junction Proteins to Disrupt the Blood Retinal Barrier and Increase Its Permeability.	TJP1 MMP9	2.11e-04	11	69	2	27605665
Pubmed	The NuRD chromatin-remodeling enzyme CHD4 promotes embryonic vascular integrity by transcriptionally regulating extracellular matrix proteolysis.	TJP1 MMP9	2.11e-04	11	69	2	24348274
Pubmed	Fine genetic and comparative mapping of the deafness mutation Ames waltzer on mouse chromosome 10.	MMP11 BCR	2.11e-04	11	69	2	9653653
Pubmed	Impaired migration and delayed differentiation of pancreatic islet cells in mice lacking EGF-receptors.	ERBB3 MMP9	2.11e-04	11	69	2	10821760
Pubmed	Cloning of the genes encoding two murine and human cochlear unconventional type I myosins.	MAST4 MYO1C	2.11e-04	11	69	2	9119401
Pubmed	Caspase-2 induces apoptosis by releasing proapoptotic proteins from mitochondria.	CRADD BCL2L1	2.53e-04	12	69	2	11832478
Pubmed	Biasing the conformation of ELMO2 reveals that myoblast fusion can be exploited to improve muscle regeneration.	ELMO2 DMD	2.53e-04	12	69	2	36400788
Pubmed	Crucial and Overlapping Roles of Six1 and Six2 in Craniofacial Development.	ALX3 SIX3	2.98e-04	13	69	2	30905259
Cytoband	18q23	SLC66A2 SMIM21	8.80e-04	29	69	2	18q23
Cytoband	Ensembl 112 genes in cytogenetic band chr18q23	SLC66A2 SMIM21	1.67e-03	40	69	2	chr18q23
Cytoband	22q11.23	MMP11 BCR	2.92e-03	53	69	2	22q11.23
GeneFamily	SINE class homeoboxes	SIX5 SIX3	1.40e-04	6	56	2	525
GeneFamily	PRD class homeoboxes and pseudogenes	ALX3 PRRX1 DUXA PRRX2	1.88e-04	92	56	4	521
GeneFamily	Armadillo repeat containing\|Protein phosphatase 1 regulatory subunits	CCDC8 SACS DZIP3 BCL2L1	2.38e-03	181	56	4	694
GeneFamily	Endogenous ligands\|Matrix metallopeptidases	MMP9 MMP11	2.49e-03	24	56	2	891
GeneFamily	Calcium voltage-gated channel subunits	CACNA1I CACNA1G	2.92e-03	26	56	2	253
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	PLEKHG4 GAB4 BCR MPRIP	3.79e-03	206	56	4	682
ToppCell	Influenza_Severe-cDC\|Influenza_Severe / Disease group and Cell class	ADRA2A SLC9A7 SLC5A9 CYP2S1 TOP1MT DNMT3B	2.28e-07	166	69	6	b40bdf0f7f381e25be61188e9f6c294d25a8b824
ToppCell	367C-Lymphocytic-CD4_T-cell-Treg_cell_4\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	MAST4 CRADD CUL9 DMD SH2D4B	3.89e-06	152	69	5	6d02b50e9e9ecf820f84a79e46d153a4840a1cfe
ToppCell	367C-Lymphocytic-CD4_T-cell-Treg_cell_4\|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)	MAST4 CRADD CUL9 DMD SH2D4B	3.89e-06	152	69	5	eb7ff36792c3c54ac88cfe976f84016b70b1a1d7
ToppCell	Posterior_cortex-Endothelial-ENDOTHELIAL_TIP\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	ALX3 ITGA11 WNT6 SIX5 PRRX2	8.39e-06	178	69	5	cda7695411655bd6d0ba69e5041ca7530a9dad3a
ToppCell	10x_3'_v2v3-Non-neoplastic-Vascular-Mural_cell-SMC_COL-F\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	ITGA11 PRRX1 MMP9 MMP11 PRRX2	1.40e-05	198	69	5	eb78b2ae6a787dbc75947e8dd5a03693285bc8be
ToppCell	10x_3'_v2v3-Non-neoplastic-Vascular-Mural_cell-SMC_COL\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	ITGA11 PRRX1 MMP9 MMP11 PRRX2	1.40e-05	198	69	5	8b9e8eaeffda40912a0163fdf39b93bc5e64751c
ToppCell	Bronchial-NucSeq-Stromal-Myofibroblastic\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	ITGA11 SACS PPFIA2 DMD PRRX2	1.47e-05	200	69	5	a66449b22b39dd6987fc2c3ed160d24564234ced
ToppCell	Thalamus-Endothelial-ENDOTHELIAL_TIP-Dcn_1-Dcn_1_1-Dcn-Endothelial_Tip.Dcn.Nenf_(Nenf)\|Thalamus / BrainAtlas - Mouse McCarroll V32	ALX3 ITGA11 WNT6 PRRX2	2.98e-05	114	69	4	7be16e7f7b9c9dbd68933ace3b7f8f661bed41a7
ToppCell	Thalamus-Endothelial-ENDOTHELIAL_TIP-Dcn_1-Dcn_1_1-Dcn\|Thalamus / BrainAtlas - Mouse McCarroll V32	ALX3 ITGA11 WNT6 PRRX2	2.98e-05	114	69	4	f4bdfc47418d22a49e0c4a6c3bd0663e15fb53bb
ToppCell	Thalamus-Endothelial-ENDOTHELIAL_TIP-Dcn_1\|Thalamus / BrainAtlas - Mouse McCarroll V32	ALX3 ITGA11 WNT6 PRRX2	9.36e-05	153	69	4	e9c6fb5c41adb6595c66c3a917fe455348279e54
ToppCell	Thalamus-Endothelial-ENDOTHELIAL_TIP-Dcn_1-Dcn_1_1\|Thalamus / BrainAtlas - Mouse McCarroll V32	ALX3 ITGA11 WNT6 PRRX2	9.36e-05	153	69	4	b8b5ff7d2feea3e3a352fb5530e49f639fe1ff88
ToppCell	Thalamus-Endothelial-ENDOTHELIAL_TIP\|Thalamus / BrainAtlas - Mouse McCarroll V32	ALX3 ITGA11 WNT6 PRRX2	9.36e-05	153	69	4	2513edfae62a44e51d3556675a096723194c966c
ToppCell	severe_influenza-cDC\|World / disease group, cell group and cell class (v2)	ADRA2A SLC5A9 CYP2S1 DNMT3B	1.14e-04	161	69	4	802f8cafb5f499e3b2ec0193d6eb1ac9320b9287
ToppCell	Influenza_Severe-cDC\|World / Disease group and Cell class	ADRA2A SLC5A9 CYP2S1 DNMT3B	1.22e-04	164	69	4	c984228f73b9aa1aaf948541f64f41ed874770cd
ToppCell	Globus_pallidus-Endothelial-ENDOTHELIAL_TIP-Dcn_1\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	ALX3 ITGA11 WNT6 PRRX2	1.25e-04	165	69	4	570483b43ccb5831feec9337b4664814431d40b1
ToppCell	Globus_pallidus-Endothelial-ENDOTHELIAL_TIP\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	ALX3 ITGA11 WNT6 PRRX2	1.25e-04	165	69	4	2026a9a07f4d314cc05c167e491312b373468e46
ToppCell	3'-Airway_Nasal-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PPFIA2 CERS3 SIX3 GRAMD4	1.28e-04	166	69	4	9fd9de82f98b9acdaa59ac98fb9664161514aec0
ToppCell	Adult-Mesenchymal-chondrocyte-D175\|Adult / Lineage, Cell type, age group and donor	PRRX1 LARS1 MMP9 PRRX2	1.34e-04	168	69	4	14071b961c9bdb54a8259b12a88237b802cbde36
ToppCell	Children_(3_yrs)-Mesenchymal-vascular_smooth_muscle_cell\|Children_(3_yrs) / Lineage, Cell type, age group and donor	ITGA11 PPFIA2 DMD PRRX2	1.50e-04	173	69	4	5416b092321c7d9b63f0418c60f2402a138355bf
ToppCell	Control-Myeloid-MoAM2,_CCL18\|Control / Condition, Lineage and Cell class	STK11 HLX MMP9 DNMT3B	1.54e-04	174	69	4	4c64ff5666812fb4efa440ba4faeca51d916d68e
ToppCell	356C-Myeloid-Macrophage-FABP4+_Macrophage_3\|Macrophage / Donor, Lineage, Cell class and subclass (all cells)	PRRX1 ADRA2A WNT6 PRRX2	1.60e-04	176	69	4	bfa1633e1b7a8a2f04d37fa07284fe9bc0199f46
ToppCell	356C-Myeloid-Macrophage-FABP4+_Macrophage_3\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	PRRX1 ADRA2A WNT6 PRRX2	1.64e-04	177	69	4	3d955ea938a1d2fb1b6d68d4997fd454bd632dfc
ToppCell	facs-Pancreas-Exocrine-3m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADRA2A MAST4 SLC9A7 ST8SIA1	1.68e-04	178	69	4	fcbbcc44271515de1969b4732b6441c012693d5f
ToppCell	droplet-Thymus-nan-24m-Lymphocytic-Double_negative_thymocyte,_DN3_(Cd8-,_Cd4-),_some_express_pre_TCR_alpha\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PLEKHG4 SLC5A9 MMP11 BCR	1.79e-04	181	69	4	d8d11ef83c4b8b6a6f5c8728e03059e45a8ad264
ToppCell	facs-Pancreas-Exocrine-18m-Mesenchymal\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ITGA11 PRRX1 WNT6 PRRX2	1.79e-04	181	69	4	269b39ac65790061d54eab47a8eeb024403f0348
ToppCell	metastatic_Brain-Fibroblasts-Myofibroblasts\|metastatic_Brain / Location, Cell class and cell subclass	ITGA11 PRRX1 MMP11 PRRX2	1.79e-04	181	69	4	bd0b5f74f9c81ec0f1592710774a4fdf33d9d5a9
ToppCell	facs-Pancreas-Exocrine-18m-Mesenchymal-pancreatic_stellate_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ITGA11 PRRX1 WNT6 PRRX2	1.79e-04	181	69	4	cd4f744b6b64ba6c22ec07afd1d3058a2546909d
ToppCell	droplet-Thymus-nan-24m-Lymphocytic-DN3_thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PLEKHG4 SLC5A9 MMP11 BCR	1.79e-04	181	69	4	e2d03115a87f45a7ddd3ade6b9ac3843639bd41a
ToppCell	facs-Pancreas-Exocrine-18m-Mesenchymal-pancreatic_stellate_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ITGA11 PRRX1 WNT6 PRRX2	1.79e-04	181	69	4	c8395ae872aa80b3ae1ab7c53e57b3ca15aeb0e2
ToppCell	10x5'-bone_marrow-Lymphocytic_B-Pre-B\|bone_marrow / Manually curated celltypes from each tissue	MYO1C SLC9A7 MMP11 DNMT3B	1.82e-04	182	69	4	a5fd392178c2f533e265d2e3ce63b90c2553e4c1
ToppCell	5'-Airway_Nasal-Mesenchymal-Fibroblastic-fibroblastic_type_2-Peribronchial_fibroblasts-Peribronchial_fibroblasts_L.2.1.3.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ITGA11 PRRX1 MMP11 PRRX2	1.86e-04	183	69	4	6d98973098c6d20c5305bce6a83a549a7d8dbfba
ToppCell	5'-Airway_Nasal-Mesenchymal-Fibroblastic-fibroblastic_type_2-Peribronchial_fibroblasts\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ITGA11 PRRX1 MMP11 PRRX2	1.86e-04	183	69	4	cc7f5a17b40e8d901885174922e5fa8877643071
ToppCell	5'-Airway_Nasal-Mesenchymal-Fibroblastic-fibroblastic_type_2\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ITGA11 PRRX1 MMP11 PRRX2	1.86e-04	183	69	4	803376f5260de83c48d4f7301278d078a32b3e6e
ToppCell	Frontal_cortex-Endothelial-ENDOTHELIAL_TIP\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	ALX3 ITGA11 WNT6 PRRX2	1.90e-04	184	69	4	235890e8b424f4386b6ea52d173d20a00898df73
ToppCell	5'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2-Peribronchial_fibroblasts-Peribronchial_fibroblasts_L.2.1.3.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ITGA11 PRRX1 MMP9 MMP11	1.94e-04	185	69	4	87c416d14ca6255bee39b16e7571553e36ee3069
ToppCell	LPS_only-Hematopoietic_Meg-Ery-Erythroid\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	STK11 NPTN CLCN3 TXNDC16	1.98e-04	186	69	4	affc246a1091e44dc85a5e237c778a7541d5a2b4
ToppCell	LPS_only-Hematopoietic_Meg-Ery\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	STK11 NPTN CLCN3 TXNDC16	1.98e-04	186	69	4	40d1e15402fdfb3b5ae850a2070cd4b68fda3159
ToppCell	LPS_only-Hematopoietic_Meg-Ery-Erythroid-Erythroid\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	STK11 NPTN CLCN3 TXNDC16	1.98e-04	186	69	4	e5014443e9d6e25943308483e20d48b776ae5373
ToppCell	5'-GW_trimst-2-LymphNode-Mesenchymal-Pericytes-angiogenic_pericyte\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ALX3 PRRX1 WNT6 MPRIP	2.02e-04	187	69	4	b8f88599e22b9b345c7ec3bbecd87a8b2a033f9f
ToppCell	droplet-Lung-1m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l17\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ITGA11 PRRX1 CACNA1G PRRX2	2.02e-04	187	69	4	ed7ab4cf4629d96dad5c74d536fc428d0a8d4eb9
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-Adaptive_/_Maladaptive_/_Repairing_Fibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ITGA11 PRRX1 ST8SIA1 DMD	2.06e-04	188	69	4	ce85a56ac27a6432421dde93a1bafa8b943244b9
ToppCell	facs-Marrow-T-cells-3m-Lymphocytic-naive_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MAST4 SLC9A7 TXNDC16 CACNA1I	2.06e-04	188	69	4	1f07e3ab87173426fe0c429f5c084fb3425effd3
ToppCell	facs-Marrow-T-cells-3m-Lymphocytic-naive_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MAST4 SLC9A7 TXNDC16 CACNA1I	2.06e-04	188	69	4	85746f95319e494efdc1bbc24331698688d3a900
ToppCell	Fetal_29-31_weeks-Mesenchymal-vascular_smooth_muscle_cell\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	ITGA11 PPFIA2 DMD MPRIP	2.15e-04	190	69	4	d6b3a92119b210974a32af3fe9875d60eb02761e
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ITGA11 PRRX1 ST8SIA1 DMD	2.15e-04	190	69	4	efb757f11c2809e66ddb48a5c84f5433f111cb7c
ToppCell	droplet-Limb_Muscle-MUSCLE-30m-Mesenchymal-smooth_muscle_cell\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADRA2A PPFIA2 DMD BCR	2.15e-04	190	69	4	1ab3f19f1ce9f58e5125135704d94655a2e330a0
ToppCell	kidney_cells-Adult_normal_reference-Mesenchymal-Fibroblast-Degenerative_Fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PRRX1 ADRA2A MMP11 PRRX2	2.24e-04	192	69	4	41a8326cd5bc19ad5041068501bab4c72399222e
ToppCell	kidney_cells-Adult_normal_reference-Mesenchymal-Fibroblast-Degenerative_Fibroblast-Degenerative_Fibroblast_119\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PRRX1 ADRA2A MMP11 PRRX2	2.24e-04	192	69	4	f88aba74d6e8c594c32fe2bc095b5da28b4b28e9
ToppCell	nucseq-Mesenchymal-Myocytic-Myocytic_2-SCMF\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	ITGA11 PRRX1 PPFIA2 MMP11	2.24e-04	192	69	4	67e845e513e76e820f55e2f0d15eb16f2944d05c
ToppCell	PBMC-Severe-Myeloid-cDC-cDC-cDC_5\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	SLC9A7 FTCDNL1 CYP2S1 TOP1MT	2.24e-04	192	69	4	6184163dbfca882824cb266bb9030d9f79e3acb0
ToppCell	renal_cortex_nuclei\|World / Celltypes from Cells and Nuclei per compartment and clinical group	MAST4 CRADD ATXN7L1 ANKRD11	2.24e-04	192	69	4	e8cc4d08fcfceeab75a02558817e4ccd7dbafe3a
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Degenerative_Fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ITGA11 PRRX1 MMP9 MMP11	2.28e-04	193	69	4	dc8e62df6121ee99b156aca6b1b3ae555739b6f2
ToppCell	nucseq-Mesenchymal-Myocytic-Myocytic_2\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	ITGA11 PRRX1 PPFIA2 MMP11	2.28e-04	193	69	4	5de87fc94a6e58899ef4124cf4887ed3ff96163a
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Degenerative_Fibroblast-Degenerative_Fibroblast_119\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ITGA11 PRRX1 MMP9 MMP11	2.28e-04	193	69	4	e2ee077fd381bd906e6b4329f22e7d106e422a7f
ToppCell	tumor_Lymph_Node_/_Brain-T/NK_cells-Treg\|T/NK_cells / Location, Cell class and cell subclass	MAST4 ARL6IP5 CUL9 MMP9	2.33e-04	194	69	4	e46963d5f156526342ebc0fb9e767d266e812c42
ToppCell	nucseq-Mesenchymal-Myocytic\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	ITGA11 PRRX1 PPFIA2 MMP11	2.33e-04	194	69	4	2d66091097e106c7bee22e5281f50724700bdf8d
ToppCell	(1)_Osterolineage_cells-(11)_OLC-2\|World / Cell class and subclass of bone marrow stroma cells in homeostatis	ITGA11 PLEKHG4 CACNA1G PRRX2	2.37e-04	195	69	4	78978d85273e5463a7f43e4c121e647fa6aba42b
ToppCell	COVID-19-Lymphoid-Tregs\|Lymphoid / Condition, Lineage and Cell class	MAST4 CRADD CUL9 MMP9	2.37e-04	195	69	4	9ad844d9d5aac39d133ae8ab9c4839300f08064c
ToppCell	3'-Broncho-tracheal-Mesenchymal-Fibroblastic-fibroblastic_type_2-Peribronchial_fibroblasts-Peribronchial_fibroblasts_L.2.1.3.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PRRX1 ADRA2A PPFIA2 PRRX2	2.37e-04	195	69	4	51db90e7611f7d69980878c046505ff34212079b
ToppCell	Tracheal-10x5prime-Stromal-Schwann\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	ERBB3 WNT6 GAB4 DMD	2.42e-04	196	69	4	b6226163d9fc93ecfff2115bb74408303a000490
ToppCell	10x3'2.3-week_17-19-Hematopoietic-erythroid-mid_erythroid\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	STK11 CLCN3 BCL2L1 ST8SIA1	2.42e-04	196	69	4	51c48944149a89b98011a50fe81ca6664d5f0d44
ToppCell	10x3'2.3-week_17-19-Hematopoietic\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	STK11 CLCN3 BCL2L1 ST8SIA1	2.42e-04	196	69	4	2aeb792e7685e33e3543a6974be790980a41ed8c
ToppCell	distal-3-Epithelial-Ionocyte\|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	ELMO2 MMP9 MMP11 DNMT3B	2.42e-04	196	69	4	6ed146481dd04fb271eadc47d68eb3ae38986db6
ToppCell	metastatic_Lymph_Node-Fibroblasts\|metastatic_Lymph_Node / Location, Cell class and cell subclass	ITGA11 PRRX1 ADRA2A MMP11	2.42e-04	196	69	4	275e153347caf94edc0c50021bbab49c8696fecb
ToppCell	Bronchial-NucSeq-Stromal-Myofibroblastic-Muscle_perivascular_immune_recruiting\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	ITGA11 PRRX1 PPFIA2 PRRX2	2.47e-04	197	69	4	cfb3dc4b401800e33c82cfc3baee69dbbd16ac8c
ToppCell	10x3'2.3-week_17-19-Hematopoietic-erythroid\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	STK11 CLCN3 BCL2L1 ST8SIA1	2.47e-04	197	69	4	b71da7f2fd8d526fb6e5d57e60fc08acdd8dbefb
ToppCell	Bronchial-NucSeq-Stromal-Myofibroblastic-Muscle_smooth_pulmonary\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	ITGA11 SACS PPFIA2 DMD	2.47e-04	197	69	4	bf0520a94ebb1d2f94de9f526d17e0b0e8fe7052
ToppCell	10x_3'_v3-tissue-resident_(10x_3'_v3)-myeloid-myeloid_monocytic-monocyte\|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	ERBB3 TJP1 WNT6 DMD	2.47e-04	197	69	4	b2f4d7c301c0b24003374923b31d6d058e40b213
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ITGA11 PRRX1 MMP9 MMP11	2.47e-04	197	69	4	4cf4e9553397cd8dee883dbec24f41bec41aff99
ToppCell	Tracheal-10x5prime-Stromal-Schwann-Schwann_nonmyelinating\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	ERBB3 WNT6 GAB4 DMD	2.47e-04	197	69	4	e239caae24f40564a24ad909754f5436f767ccdb
ToppCell	3'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_1-Subpleural_fibroblasts-Subpleural_fibroblasts_L.2.1.5.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PRRX1 ADRA2A WNT6 PRRX2	2.52e-04	198	69	4	c66097ae9ba0b50561083c423565665958ef0bb8
ToppCell	AT1-AT2_cells\|World / lung cells shred on cell class, cell subclass, sample id	ERBB3 MYO1C TJP1 SLC25A23	2.52e-04	198	69	4	a5b3617ea2ed4bffba59edcf6284799c2b3bbb29
ToppCell	356C-Fibroblasts-Fibroblast-J_(Lipofibroblast)\|356C / Donor, Lineage, Cell class and subclass (all cells)	PRRX1 ADRA2A WNT6 PRRX2	2.56e-04	199	69	4	675f7c56b03a7918e2d9ca99440df6f27ad8e838
ToppCell	Tracheal-10x3prime_v2-Stromal-Schwann\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	ERBB3 WNT6 MMP11 ZNF598	2.56e-04	199	69	4	8dc65662c3ca1db2ba0091332f0658abc0afc5de
ToppCell	356C-Fibroblasts-Fibroblast-J_(Lipofibroblast)-\|356C / Donor, Lineage, Cell class and subclass (all cells)	PRRX1 ADRA2A WNT6 PRRX2	2.56e-04	199	69	4	97d74985018816754d11a55b9fb689690ecb1374
ToppCell	Tracheal-10x3prime_v2-Stromal-Schwann-Schwann_nonmyelinating\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	ERBB3 WNT6 MMP11 ZNF598	2.56e-04	199	69	4	a92718a3f1153b8d2196fd343ed5bc0ebc98cad7
ToppCell	facs-Brain_Non-Myeloid-Hippocampus\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MAST4 CLCN3 ANKRD11 TXNDC16	2.61e-04	200	69	4	fc28f71ca1cd0fdae66009ae5afe175d22f2bd8c
ToppCell	Tracheal-NucSeq-Stromal-Fibroblastic-Fibro_perichondrial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	ITGA11 PRRX1 PPFIA2 PRRX2	2.61e-04	200	69	4	a4ec0e80f5422b91b85264a9bb74568dd577e285
ToppCell	Influenza-Influenza_Severe-Myeloid-cDC\|Influenza_Severe / Disease, condition lineage and cell class	SLC9A7 CYP2S1 TOP1MT DNMT3B	2.61e-04	200	69	4	b8415a68ad6f4fea562236a1b0da0dc376d874fb
ToppCell	(5)_Fibroblast-B_(Myofibroblast)\|World / Lung cell shreds - cell class (v4) and cell subclass (v4)	ITGA11 PRRX1 PPFIA2 MMP11	2.61e-04	200	69	4	9bbaa666d0f3b4782c1b4b95e0fa5fc1467842d8
ToppCell	tumor_Lymph_Node_/_Brain-Fibroblasts-Myofibroblasts\|tumor_Lymph_Node_/_Brain / Location, Cell class and cell subclass	ITGA11 PRRX1 MMP11 PRRX2	2.61e-04	200	69	4	ca777a7d001848f6d01c613ff2bda7e4f3e20521
Disease	reaction time measurement	GATAD2A ARL6IP5 DCP2 TXNDC16 LHX3 MMP9 SIX3 SMIM21	1.33e-04	658	68	8	EFO_0008393
Disease	Holoprosencephaly sequence	PRRX1 SIX3	2.33e-04	10	68	2	cv:C0079541
Disease	skin melanoma (is_marker_for)	MMP9 DNMT3B	4.02e-04	13	68	2	DOID:8923 (is_marker_for)
Disease	Non-Small Cell Lung Carcinoma	STK11 ERGIC3 MMP9 MMP11	4.71e-04	156	68	4	C0007131
Disease	Neoplasms, Experimental	ERGIC3 ARL6IP5 BCR	4.83e-04	66	68	3	C0027659
Disease	anorexia nervosa	ERBB3 PHIP SMIM21	5.74e-04	70	68	3	MONDO_0005351
Disease	Stomach Neoplasms	ERBB3 CLCN3 ARL6IP5 BCL2L1 DNMT3B	6.20e-04	297	68	5	C0038356
Disease	Liver diseases	BCL2L1 ST8SIA1 MMP9	6.23e-04	72	68	3	C0023895
Disease	Liver Dysfunction	BCL2L1 ST8SIA1 MMP9	6.23e-04	72	68	3	C0086565
Disease	Malignant neoplasm of stomach	ERBB3 CLCN3 ARL6IP5 BCL2L1 DNMT3B	6.49e-04	300	68	5	C0024623
Disease	ocular hypertension (biomarker_via_orthology)	BCL2L1 MMP9	6.96e-04	17	68	2	DOID:9282 (biomarker_via_orthology)
Disease	cortical surface area measurement	ALX3 ITGA11 ERBB3 MAST4 TJP1 CUL9 MARCHF7 SIX3 BCR MPRIP	9.79e-04	1345	68	10	EFO_0010736
Disease	Hypertensive disease	STK11 NPTN ADRA2A MMP9	9.83e-04	190	68	4	C0020538
Disease	chronic myeloid leukemia (is_implicated_in)	BCL2L1 BCR	1.07e-03	21	68	2	DOID:8552 (is_implicated_in)
Disease	Stomach Carcinoma	STK11 ERBB3	1.07e-03	21	68	2	C0699791
Disease	Colorectal Carcinoma	STK11 SLC66A2 ERGIC3 SACS DMD MMP11 PHIP	1.15e-03	702	68	7	C0009402
Disease	Nasopharyngeal carcinoma	ERBB3 CLCN3	1.17e-03	22	68	2	C2931822
Disease	status epilepticus (biomarker_via_orthology)	BCL2L1 DMD MMP9	1.61e-03	100	68	3	DOID:1824 (biomarker_via_orthology)
Disease	Pancreatic Neoplasm	STK11 BCL2L1 MMP9	1.61e-03	100	68	3	C0030297
Disease	Malignant neoplasm of pancreas	STK11 BCL2L1 MMP9	1.71e-03	102	68	3	C0346647
Disease	colorectal adenocarcinoma (is_marker_for)	ERBB3 BCL2L1	1.77e-03	27	68	2	DOID:0050861 (is_marker_for)
Disease	chronic myeloid leukemia (is_marker_for)	BCR DNMT3B	1.77e-03	27	68	2	DOID:8552 (is_marker_for)
Disease	Cerebral Hemorrhage	BCL2L1 MMP9	1.90e-03	28	68	2	C2937358
Disease	chronic obstructive pulmonary disease (biomarker_via_orthology)	ERBB3 MMP9	1.90e-03	28	68	2	DOID:3083 (biomarker_via_orthology)
Disease	urinary bladder cancer (is_marker_for)	ERBB3 BCL2L1 MMP9	1.96e-03	107	68	3	DOID:11054 (is_marker_for)
Disease	Toxic Encephalitis	BCL2L1 ST8SIA1	2.04e-03	29	68	2	C0154659
Disease	Neurotoxicity Syndromes	BCL2L1 ST8SIA1	2.04e-03	29	68	2	C0235032
Disease	Encephalopathy, Toxic	BCL2L1 ST8SIA1	2.04e-03	29	68	2	C0149504
Disease	lower face morphology measurement	ITGA11 PRRX1 HLX	2.06e-03	109	68	3	EFO_0010948
Disease	pancreatic cancer (is_implicated_in)	STK11 ITGA11 BCL2L1	2.23e-03	112	68	3	DOID:1793 (is_implicated_in)

Protein segments in the cluster

Peptide	Gene	Start	Entry
GTFLYWRGRRIQNKR	ERBB3	661	P21860
KSVRDRFNARQFISW	ANKRD11	2576	Q6UB99
LRRRKDWNVRLQAFF	DNMT3B	536	Q9UBC3
FQNRRAKWRKRERYG	ALX3	201	O95076
EKKSYDRQRWGFRRA	BCR	66	P11274
ERRSQGLSSRLQKWF	GRAMD4	156	Q6IC98
AESRKGQERFNRWFL	BCL2L1	201	Q07817
FNPKTRREIRNIEWF	DCP2	186	Q8IU60
WREIESKFAQFRRLN	DMD	1956	P11532
QGRFDRSVEKWRRFH	DMD	2096	P11532
VGRWFEAFVKRRNRN	DNAJC2	31	Q99543
FDRRWDRFRFALNSM	ATXN7L1	481	Q9ULK2
EFGRNRERLQFFKWS	IREB2	221	P48200
RERLQFFKWSSRVFK	IREB2	226	P48200
ARVQVWFQNRRAKFR	PRRX2	146	Q99811
WFQNRRAKFRRNERA	PRRX2	151	Q99811
GWSRRFRFRALKNGA	ACP7	116	Q6ZNF0
RKLAFRSGEARDWSN	GATAD2A	506	Q86YP4
LFSGRRLWRFDVKAQ	MMP9	626	P14780
NPVHRSRKWQRRFFI	MPRIP	61	Q6WCQ1
RSWSRAVFSNLQRKG	HLX	276	Q14774
VFFSNGERWRQLRKF	CYP2S1	116	Q96SQ9
DVREAYRRRGWAFKN	ERGIC3	161	Q9Y282
WFGTFIRNGQQRKRE	INTS2	316	Q9H0H0
AAKFRQFWGSRSELR	NOL6	576	Q9H6R4
RQRWGQYFRNMKRSR	LHX3	221	Q9UBR4
LALWKLGFFRSARRR	ITGA11	1161	Q9UKX5
WKTNFRCALRSTRRF	IRF7	91	Q92985
DFKRQLRTVTFRWQE	DZIP3	766	Q86Y13
WFRSRRNQERPSRLK	CERS3	116	Q8IU89
GFRRFFQDRWNQLDL	CACNA1G	1666	O43497
RKIGNRRRQERFWYC	ELMO2	556	Q96JJ3
RKRWFILRRGQTSSD	GAB4	61	Q2WGN9
FGLRRFFKDRWNQLD	CACNA1I	1541	Q9P0X4
VEAFIRWRQRFGKQA	CRADD	161	P78560
RWRQRFGKQATFQSL	CRADD	166	P78560
ASEASQGFRFLRRRW	MARCHF7	341	Q9H992
VFNRAFYSWGRRKAR	MBTPS2	56	O43462
RFFRSLDWNSLLRQK	MAST4	841	O15021
PRRQGWVFRQRSEFS	CUL9	356	Q8IWT3
QRRKQLGWFTRRDFS	FTCDNL1	101	E5RQL4
QTPGRFSWFCKRRRA	CCDC8	481	Q9H0W5
GFFGLTDNRRSIKWR	SACS	466	Q9NZJ4
IWFQNRRARHGFQKR	DUXA	61	A6NLW8
SDDKNFRRGSTWRRQ	PPFIA2	1186	O75334
ARNRQKRFVLSGGRW	MMP11	91	P24347
SFRERFGRNWLQYRS	STK11IP	421	Q8N1F8
RKAFRDLWNFISSSR	TDRD15	881	B5MCY1
GNSNLRFEIWFRRRK	PLEKHG4	986	Q58EX7
SFVRWQFLTLRERNK	LARS1	216	Q9P2J5
FARPDFRDISKWNNR	ARL6IP5	21	O75915
GNWFKNRRQRDRAAA	SIX3	251	O95343
SNWFKNRRQRDRTGA	SIX5	246	Q8N196
TAWRRNQTAARAFRK	ST8SIA1	66	Q92185
STLFTIDVWQRFRRK	SLC5A9	406	Q2M3M2
KRFSIRQIRQHSWFR	STK11	296	Q15831
RWRGRQNREKRFTFV	ADRA2A	376	P08913
FFIRANIAWCRRRKS	CLCN3	406	P51790
NRSNWFKEAEKSFRR	TXNDC16	801	Q9P2K2
QLKRFSFRSFIWRDK	USP19	1106	O94966
AKYRRWNIGDRFRSV	PHIP	1061	Q8WWQ0
RAESFRQLWDGARKR	NPTN	71	Q9Y639
AWQKFETARRLRGFV	TOP1MT	276	Q969P6
LGVRECQFQFRFRRW	WNT6	71	Q9Y6F9
EDWKRANSIFRNFLR	SMIM21	76	Q3B7S5
FWRFRGLRSSKRNLR	TJP1	601	Q07157
AQQSRRGSWRYKREE	ZNF598	326	Q86UK7
RQRWGRLFEELDSNK	SLC25A23	11	Q9BV35
RRAGFERNTKFIAPW	SH2D4B	311	Q5SQS7
ARVQVWFQNRRAKFR	PRRX1	136	P54821
WFQNRRAKFRRNERA	PRRX1	141	P54821
RGNRTKQESAWIFRL	SLC9A7	586	Q96T83
NILRILFWFGRRFES	SLC66A2	61	Q8N2U9
RGFHWRQKFLRVKRS	MYO1C	746	O00159