Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	transmembrane transporter activity	LRRC8A ABCC3 COX15 SLC37A3 KCNK17 ATP1A4 PKD1L3 TRPM3 LRRC8D SLC14A2 CLCC1 SLC17A6	1.91e-07	1180	33	12	GO:0022857
GeneOntologyMolecularFunction	transporter activity	LRRC8A ABCC3 COX15 SLC37A3 KCNK17 ATP1A4 PKD1L3 TRPM3 LRRC8D SLC14A2 CLCC1 SLC17A6	4.95e-07	1289	33	12	GO:0005215
GeneOntologyMolecularFunction	inorganic molecular entity transmembrane transporter activity	ABCC3 COX15 SLC37A3 KCNK17 ATP1A4 PKD1L3 TRPM3 CLCC1 SLC17A6	2.65e-06	758	33	9	GO:0015318
GeneOntologyMolecularFunction	monoatomic ion transmembrane transporter activity	LRRC8A COX15 KCNK17 ATP1A4 PKD1L3 TRPM3 LRRC8D CLCC1 SLC17A6	3.84e-06	793	33	9	GO:0015075
GeneOntologyMolecularFunction	monoatomic ion channel activity	LRRC8A KCNK17 PKD1L3 TRPM3 LRRC8D CLCC1 SLC17A6	8.25e-06	459	33	7	GO:0005216
GeneOntologyMolecularFunction	channel activity	LRRC8A KCNK17 PKD1L3 TRPM3 LRRC8D CLCC1 SLC17A6	1.97e-05	525	33	7	GO:0015267
GeneOntologyMolecularFunction	passive transmembrane transporter activity	LRRC8A KCNK17 PKD1L3 TRPM3 LRRC8D CLCC1 SLC17A6	1.99e-05	526	33	7	GO:0022803
GeneOntologyMolecularFunction	monoatomic anion channel activity	LRRC8A LRRC8D CLCC1 SLC17A6	2.44e-05	103	33	4	GO:0005253
GeneOntologyMolecularFunction	volume-sensitive anion channel activity	LRRC8A LRRC8D	9.47e-05	9	33	2	GO:0005225
GeneOntologyMolecularFunction	monoatomic anion transmembrane transporter activity	LRRC8A LRRC8D CLCC1 SLC17A6	1.08e-04	151	33	4	GO:0008509
GeneOntologyMolecularFunction	carbohydrate derivative transmembrane transporter activity	LRRC8A ABCC3 SLC37A3	1.26e-04	59	33	3	GO:1901505
GeneOntologyMolecularFunction	inorganic anion transmembrane transporter activity	ABCC3 SLC37A3 CLCC1 SLC17A6	1.75e-04	171	33	4	GO:0015103
GeneOntologyMolecularFunction	inorganic cation transmembrane transporter activity	COX15 KCNK17 ATP1A4 PKD1L3 TRPM3 SLC17A6	5.03e-04	627	33	6	GO:0022890
GeneOntologyMolecularFunction	monoatomic cation transmembrane transporter activity	COX15 KCNK17 ATP1A4 PKD1L3 TRPM3 SLC17A6	6.80e-04	664	33	6	GO:0008324
GeneOntologyMolecularFunction	phosphate transmembrane transporter activity	SLC37A3 SLC17A6	7.15e-04	24	33	2	GO:0005315
GeneOntologyMolecularFunction	metal ion transmembrane transporter activity	KCNK17 ATP1A4 PKD1L3 TRPM3 SLC17A6	9.28e-04	465	33	5	GO:0046873
GeneOntologyMolecularFunction	active transmembrane transporter activity	ABCC3 COX15 SLC37A3 ATP1A4 SLC17A6	1.04e-03	477	33	5	GO:0022804
GeneOntologyMolecularFunction	organic anion transmembrane transporter activity	LRRC8A ABCC3 SLC37A3 SLC17A6	1.33e-03	293	33	4	GO:0008514
GeneOntologyMolecularFunction	xenobiotic transmembrane transporter activity	ABCC3 SLC37A3	1.44e-03	34	33	2	GO:0042910
GeneOntologyMolecularFunction	organophosphate ester transmembrane transporter activity	LRRC8A SLC37A3	1.89e-03	39	33	2	GO:0015605
GeneOntologyMolecularFunction	potassium ion transmembrane transporter activity	KCNK17 ATP1A4 SLC17A6	2.61e-03	167	33	3	GO:0015079
GeneOntologyMolecularFunction	primary active transmembrane transporter activity	ABCC3 COX15 ATP1A4	3.12e-03	178	33	3	GO:0015399
GeneOntologyMolecularFunction	chloride channel activity	CLCC1 SLC17A6	8.88e-03	86	33	2	GO:0005254
GeneOntologyMolecularFunction	oxidoreductase activity, acting on NAD(P)H	AIFM3 COX15	1.07e-02	95	33	2	GO:0016651
GeneOntologyMolecularFunction	active monoatomic ion transmembrane transporter activity	COX15 ATP1A4 SLC17A6	1.32e-02	301	33	3	GO:0022853
GeneOntologyMolecularFunction	ATPase-coupled transmembrane transporter activity	ABCC3 ATP1A4	1.40e-02	109	33	2	GO:0042626
GeneOntologyBiologicalProcess	monoatomic ion transmembrane transport	LRRC8A ABCC3 COX15 KCNK17 ATP1A4 PKD1L3 DYSF TRPM3 LRRC8D CLCC1 SLC17A6	4.95e-07	1115	32	11	GO:0034220
GeneOntologyBiologicalProcess	inorganic ion transmembrane transport	LRRC8A COX15 SLC37A3 KCNK17 ATP1A4 PKD1L3 DYSF TRPM3 CLCC1 SLC17A6	1.94e-06	1017	32	10	GO:0098660
GeneOntologyBiologicalProcess	monoatomic anion transmembrane transport	LRRC8A ABCC3 LRRC8D CLCC1 SLC17A6	3.60e-06	153	32	5	GO:0098656
GeneOntologyBiologicalProcess	monoatomic ion transport	LRRC8A ABCC3 COX15 KCNK17 ATP1A4 PKD1L3 DYSF TRPM3 LRRC8D CLCC1 SLC17A6	3.86e-06	1374	32	11	GO:0006811
GeneOntologyBiologicalProcess	monoatomic anion transport	LRRC8A ABCC3 LRRC8D CLCC1 SLC17A6	8.63e-06	183	32	5	GO:0006820
GeneOntologyBiologicalProcess	carbohydrate derivative transport	LRRC8A ABCC3 SLC37A3 LRRC8D	1.43e-05	96	32	4	GO:1901264
GeneOntologyBiologicalProcess	inorganic anion transmembrane transport	LRRC8A SLC37A3 CLCC1 SLC17A6	5.32e-05	134	32	4	GO:0098661
GeneOntologyBiologicalProcess	cyclic-GMP-AMP transmembrane import across plasma membrane	LRRC8A LRRC8D	6.49e-05	8	32	2	GO:0140361
GeneOntologyBiologicalProcess	alkanesulfonate transmembrane transport	LRRC8A LRRC8D	6.49e-05	8	32	2	GO:0042918
GeneOntologyBiologicalProcess	taurine transmembrane transport	LRRC8A LRRC8D	6.49e-05	8	32	2	GO:0015734
GeneOntologyBiologicalProcess	protein hexamerization	LRRC8A LRRC8D	8.34e-05	9	32	2	GO:0034214
GeneOntologyBiologicalProcess	guanine nucleotide transmembrane transport	LRRC8A LRRC8D	1.04e-04	10	32	2	GO:1903790
GeneOntologyBiologicalProcess	cyclic nucleotide transport	LRRC8A LRRC8D	1.27e-04	11	32	2	GO:0070729
GeneOntologyBiologicalProcess	guanine nucleotide transport	LRRC8A LRRC8D	1.27e-04	11	32	2	GO:0001408
GeneOntologyBiologicalProcess	inorganic anion transport	LRRC8A SLC37A3 CLCC1 SLC17A6	1.67e-04	180	32	4	GO:0015698
GeneOntologyBiologicalProcess	xenobiotic transmembrane transport	ABCC3 SLC37A3	3.92e-04	19	32	2	GO:0006855
GeneOntologyBiologicalProcess	inorganic cation transmembrane transport	COX15 KCNK17 ATP1A4 PKD1L3 DYSF TRPM3 SLC17A6	4.40e-04	922	32	7	GO:0098662
GeneOntologyBiologicalProcess	monoatomic cation transmembrane transport	COX15 KCNK17 ATP1A4 PKD1L3 DYSF TRPM3 SLC17A6	5.00e-04	942	32	7	GO:0098655
GeneOntologyBiologicalProcess	aspartate transmembrane transport	LRRC8A LRRC8D	5.28e-04	22	32	2	GO:0015810
GeneOntologyBiologicalProcess	chloride transmembrane transport	LRRC8A CLCC1 SLC17A6	6.89e-04	112	32	3	GO:1902476
GeneOntologyBiologicalProcess	response to osmotic stress	LRRC8A DYSF LRRC8D	7.07e-04	113	32	3	GO:0006970
GeneOntologyBiologicalProcess	amino acid transmembrane transport	LRRC8A LRRC8D SLC17A6	8.42e-04	120	32	3	GO:0003333
GeneOntologyBiologicalProcess	dicarboxylic acid transport	LRRC8A LRRC8D SLC17A6	8.42e-04	120	32	3	GO:0006835
GeneOntologyBiologicalProcess	positive regulation of fatty acid biosynthetic process	ELOVL5 LPGAT1	9.22e-04	29	32	2	GO:0045723
GeneOntologyBiologicalProcess	C4-dicarboxylate transport	LRRC8A LRRC8D	9.22e-04	29	32	2	GO:0015740
GeneOntologyBiologicalProcess	chloride transport	LRRC8A CLCC1 SLC17A6	1.02e-03	128	32	3	GO:0006821
GeneOntologyBiologicalProcess	phosphate ion transport	SLC37A3 SLC17A6	1.05e-03	31	32	2	GO:0006817
GeneOntologyBiologicalProcess	nucleotide transmembrane transport	LRRC8A LRRC8D	1.05e-03	31	32	2	GO:1901679
GeneOntologyBiologicalProcess	organic anion transport	LRRC8A ABCC3 SLC37A3 LRRC8D SLC17A6	1.10e-03	515	32	5	GO:0015711
GeneOntologyBiologicalProcess	monoatomic cation transport	COX15 KCNK17 ATP1A4 PKD1L3 DYSF TRPM3 SLC17A6	1.68e-03	1157	32	7	GO:0006812
GeneOntologyBiologicalProcess	purine-containing compound transmembrane transport	LRRC8A LRRC8D	1.75e-03	40	32	2	GO:0072530
GeneOntologyBiologicalProcess	purine ribonucleotide transport	LRRC8A LRRC8D	1.75e-03	40	32	2	GO:0015868
GeneOntologyBiologicalProcess	adenine nucleotide transport	LRRC8A LRRC8D	1.93e-03	42	32	2	GO:0051503
GeneOntologyBiologicalProcess	organophosphate ester transport	LRRC8A SLC37A3 LRRC8D	2.00e-03	162	32	3	GO:0015748
GeneOntologyBiologicalProcess	carboxylic acid transmembrane transport	LRRC8A LRRC8D SLC17A6	2.03e-03	163	32	3	GO:1905039
GeneOntologyBiologicalProcess	positive regulation of lipid metabolic process	ELOVL5 LPGAT1 ANGPTL4	2.10e-03	165	32	3	GO:0045834
GeneOntologyBiologicalProcess	purine nucleotide transport	LRRC8A LRRC8D	2.12e-03	44	32	2	GO:0015865
GeneOntologyBiologicalProcess	organic acid transmembrane transport	LRRC8A LRRC8D SLC17A6	2.18e-03	167	32	3	GO:1903825
GeneOntologyBiologicalProcess	proton transmembrane transport	COX15 ATP1A4 SLC17A6	2.29e-03	170	32	3	GO:1902600
GeneOntologyCellularComponent	transmembrane transporter complex	LRRC8A KCNK17 ATP1A4 PKD1L3 LRRC8D CLCC1 SLC17A6	1.43e-05	523	33	7	GO:1902495
GeneOntologyCellularComponent	transporter complex	LRRC8A KCNK17 ATP1A4 PKD1L3 LRRC8D CLCC1 SLC17A6	1.98e-05	550	33	7	GO:1990351
GeneOntologyCellularComponent	monoatomic ion channel complex	LRRC8A KCNK17 PKD1L3 LRRC8D CLCC1 SLC17A6	2.46e-05	378	33	6	GO:0034702
GeneOntologyCellularComponent	membrane protein complex	LRRC8A COX15 CALCR KCNK17 ATP1A4 PKD1L3 LRRC8D CLCC1 SLC17A6	3.88e-04	1498	33	9	GO:0098796
Domain	LRRC8_Pannexin-like	LRRC8A LRRC8D	2.83e-05	5	32	2	IPR021040
Domain	Pannexin_like	LRRC8A LRRC8D	2.83e-05	5	32	2	PF12534
Domain	MFS	SLC37A3 SLC17A6	7.68e-03	77	32	2	IPR011701
Domain	MFS_1	SLC37A3 SLC17A6	7.68e-03	77	32	2	PF07690
Domain	MFS	SLC37A3 SLC17A6	1.47e-02	108	32	2	PS50850
Pathway	REACTOME_TRANSPORT_OF_SMALL_MOLECULES	LRRC8A ABCC3 ATP1A4 TRPM3 LRRC8D SLC14A2 ANGPTL4 SLC17A6	1.05e-05	681	24	8	MM14985
Pathway	REACTOME_TRANSPORT_OF_SMALL_MOLECULES	LRRC8A ABCC3 ATP1A4 TRPM3 LRRC8D SLC14A2 ANGPTL4 SLC17A6	1.85e-05	736	24	8	M27287
Pubmed	LRRC8/VRAC anion channels enhance β-cell glucose sensing and insulin secretion.	LRRC8A LRRC8D	2.62e-06	3	33	2	29773801
Pubmed	LRRC8 Proteins Form Volume-Regulated Anion Channels that Sense Ionic Strength.	LRRC8A LRRC8D	5.23e-06	4	33	2	26824658
Pubmed	Selective transport of neurotransmitters and modulators by distinct volume-regulated LRRC8 anion channels.	LRRC8A LRRC8D	5.23e-06	4	33	2	28193731
Pubmed	LRRC8A:C/E Heteromeric Channels Are Ubiquitous Transporters of cGAMP.	LRRC8A LRRC8D	5.23e-06	4	33	2	33171122
Pubmed	Renal Deletion of LRRC8/VRAC Channels Induces Proximal Tubulopathy.	LRRC8A LRRC8D	8.72e-06	5	33	2	35777784
Pubmed	LRRC8 involved in B cell development belongs to a novel family of leucine-rich repeat proteins.	LRRC8A LRRC8D	8.72e-06	5	33	2	15094057
Pubmed	Identification of LRRC8 heteromers as an essential component of the volume-regulated anion channel VRAC.	LRRC8A LRRC8D	8.72e-06	5	33	2	24790029
Pubmed	ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.	ELOVL5 LRRC8A LPGAT1 ABCC3 LRRC8D CLCC1 ALG9 CLPTM1	1.27e-05	1201	33	8	35696571
Pubmed	MicroRNA-30c reduces hyperlipidemia and atherosclerosis in mice by decreasing lipid synthesis and lipoprotein secretion.	ELOVL5 LPGAT1	1.31e-05	6	33	2	23749231
Pubmed	Area Postrema Cell Types that Mediate Nausea-Associated Behaviors.	CALCR SLC17A6	2.44e-05	8	33	2	33278342
Pubmed	NTS Prlh overcomes orexigenic stimuli and ameliorates dietary and genetic forms of obesity.	CALCR SLC17A6	3.91e-05	10	33	2	34462445
Pubmed	Transfer of cGAMP into Bystander Cells via LRRC8 Volume-Regulated Anion Channels Augments STING-Mediated Interferon Responses and Anti-viral Immunity.	LRRC8A LRRC8D	5.73e-05	12	33	2	32277911
Pubmed	FAM105A/OTULINL Is a Pseudodeubiquitinase of the OTU-Class that Localizes to the ER Membrane.	LRRC8A LRRC8D CLCC1 ALG9 CLPTM1	7.51e-05	468	33	5	31056421
Pubmed	Defining the membrane proteome of NK cells.	ELOVL5 LRRC8A LPGAT1 LRRC8D CLCC1 ALG9 CLPTM1	9.40e-05	1168	33	7	19946888
Pubmed	A quantitative analysis of the spatiotemporal pattern of transient receptor potential gene expression in the developing mouse cochlea.	PKD1L3 TRPM3	4.53e-04	33	33	2	19834762
Pubmed	The interactome of metabolic enzyme carbonic anhydrase IX reveals novel roles in tumor cell migration and invadopodia/MMP14-mediated invasion.	LRRC8A CLCC1 ALG9	6.22e-04	176	33	3	28692057
Pubmed	F-box only protein 9 is an E3 ubiquitin ligase of PPARγ.	AIFM3 PKD1L3	6.66e-04	40	33	2	27197753
Pubmed	Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.	ELOVL5 LRRC8A ANGPTL4 CLPTM1	7.10e-04	430	33	4	16303743
Pubmed	Developmental waves of mechanosensitivity acquisition in sensory neuron subtypes during embryonic development.	PKD1L3 TRPM3	8.06e-04	44	33	2	19322198
Pubmed	Identification of APBB1 as a substrate for anaplastic lymphoma kinase.	CLCC1 CLPTM1	8.06e-04	44	33	2	39115278
Interaction	HTR3A interactions	LRRC8A PCNX3 LRRC8D ALG9 CLPTM1	7.23e-07	108	32	5	int:HTR3A
Interaction	GPR108 interactions	ELOVL5 TMEM17 CLPTM1	9.22e-06	26	32	3	int:GPR108
Interaction	FAM219A interactions	ELOVL5 MTA1 TMEM17	6.77e-05	50	32	3	int:FAM219A
Interaction	TSPAN15 interactions	LRRC8A LPGAT1 COX15 PCNX3 CLCC1	6.91e-05	276	32	5	int:TSPAN15
Interaction	SLC17A2 interactions	PCNX3 LRRC8D ALG9	9.52e-05	56	32	3	int:SLC17A2
Interaction	TTYH1 interactions	LRRC8A PCNX3 LRRC8D CLCC1 ALG9	1.02e-04	300	32	5	int:TTYH1
Interaction	CANX interactions	ELOVL5 LRRC8A LPGAT1 ABCC3 COX15 KDM4C CLCC1 ALG9 CLPTM1	1.08e-04	1261	32	9	int:CANX
Interaction	CRELD1 interactions	ELOVL5 LRRC8A ABCC3 COX15	1.24e-04	163	32	4	int:CRELD1
Interaction	OR10H2 interactions	LRRC8A PCNX3 LRRC8D	2.01e-04	72	32	3	int:OR10H2
Interaction	CLCC1 interactions	ELOVL5 COX15 TMEM17 CLCC1	2.24e-04	190	32	4	int:CLCC1
Interaction	LYSMD3 interactions	ELOVL5 TMEM17	2.53e-04	15	32	2	int:LYSMD3
GeneFamily	Volume regulated anion channel subunits	LRRC8A LRRC8D	1.28e-05	5	21	2	1158
GeneFamily	Solute carriers	SLC37A3 SLC14A2 SLC17A6	1.03e-02	395	21	3	752
Computational	Genes in the cancer module 239.	ELOVL5 LRRC8A LPGAT1	3.58e-04	120	13	3	MODULE_239
Disease	urate measurement	CHST1 DYSF PCNX3 SLC14A2 ALG9 GNRHR2	4.21e-04	895	33	6	EFO_0004531
Disease	mean platelet volume	ELOVL5 LRRC8A PCNX3 TRPM3 LRRC8D ALG9	8.37e-04	1020	33	6	EFO_0004584
Disease	cholesteryl esters to total lipids in small LDL percentage	ANGPTL4 CLPTM1	1.02e-03	42	33	2	EFO_0022255
Disease	alcohol use disorder (implicated_via_orthology)	ATP1A4 KDM4C ANGPTL4	1.34e-03	195	33	3	DOID:1574 (implicated_via_orthology)
Disease	fibroblast growth factor basic measurement	PCNX3 CLCC1	1.99e-03	59	33	2	EFO_0008130
Disease	free cholesterol in large HDL measurement	ANGPTL4 CLPTM1	3.54e-03	79	33	2	EFO_0022157
Disease	age at menarche	CHST1 TRPM3 KDM4C SLC14A2	4.19e-03	594	33	4	EFO_0004703
Disease	phospholipids:total lipids ratio, high density lipoprotein cholesterol measurement	PKD1L3 ANGPTL4 CLPTM1	4.83e-03	307	33	3	EFO_0004612, EFO_0020946

Protein segments in the cluster

Peptide	Gene	Start	Entry
KGIFWKTWRGRYYPL	ANGPTL4	376	Q9BY76
PYLWTAMFGKSLRYA	AIFM3	511	Q96NN9
KQRLRWYYLLGWGFP	CALCR	256	P30988
PYWLTLAPMYIWFII	ALG9	346	Q9H6U8
WWFTKMAIYGYRHPL	ABCC3	221	O15438
FYGLICMYTLWWMLR	LRRC8A	331	Q8IWT6
SKRFWYIEGIMYKWL	LPGAT1	51	Q92604
TKLTWGPYLWFYMLR	FAM177A1	91	Q8N128
ATYYRFWYPKWEMPR	GLIPR1L2	231	Q4G1C9
SMRPYLWWKKYITQG	ELOVL5	191	Q9NYP7
YKYWLLPGRWTSVRY	PCNX3	761	Q9H6A9
RYPLWYKNMVSLWIL	KCNK17	236	Q96T54
PYLYFGMWKTTFAWH	KDM4C	176	Q9H3R0
GRLMWLYLKYWELVV	CCDC127	231	Q96BQ5
LVYILPAAYFWRKGW	COX15	161	Q7KZN9
LWFTSPYKTMKFILW	DYSF	2026	O75923
TYRILKPWWDVFMDY	LRRC8D	16	Q7L1W4
TPYYLLGMWYWFSPT	GNRHR2	191	Q96P88
MFFKGGSWLWLYIRT	PKD1L3	1	Q7Z443
PWKSLTSIIEYYYMW	MTA1	316	Q13330
MYPLKITWWLCAIPY	ATP1A4	986	Q13733
KGWYSWVLSMLYGFL	CLPTM1	501	O96005
YRLWRLWYGTGRKPY	CHST1	251	O43916
FLFSLGWNWMYLYKL	CLCC1	221	Q96S66
TYYFPLWWVSSIMML	TMEM17	51	Q86X19
WYMFWLLVSYESPAK	SLC17A6	256	Q9P2U8
KFWNTYLSGLMYWPF	MPV17L	121	Q2QL34
SLIRDKLGWMWVFYF	SLC37A3	446	Q8NCC5
PSWKLAKNIFYMPYW	TRPM3	1061	Q9HCF6
WLAREYVWFLIPYMI	TLCD3A	71	Q8TBR7
LGYCMLKWLYGFLPW	VRK3	376	Q8IV63
FIAYYMITGPWRSLW	GTF3C5	286	Q9Y5Q8
KGDYYWWLLLPVIIM	SLC14A2	661	Q15849