Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	detection of mechanical stimulus involved in sensory perception	HTR2A TRPA1 GRIN2A REST	1.61e-05	57	55	4	GO:0050974
GeneOntologyBiologicalProcess	detection of mechanical stimulus involved in sensory perception of pain	HTR2A TRPA1 GRIN2A	4.47e-05	26	55	3	GO:0050966
GeneOntologyBiologicalProcess	detection of mechanical stimulus	HTR2A TRPA1 GRIN2A REST	4.78e-05	75	55	4	GO:0050982
GeneOntologyBiologicalProcess	regulation of binding	RALB TTBK2 NSD1 EIF3C REST KDM1A USP33	8.37e-05	396	55	7	GO:0051098
GeneOntologyBiologicalProcess	negative regulation of binding	RALB TTBK2 REST KDM1A USP33	8.94e-05	170	55	5	GO:0051100
GeneOntologyBiologicalProcess	negative regulation of protein binding	RALB TTBK2 KDM1A USP33	1.84e-04	106	55	4	GO:0032091
GeneOntologyBiologicalProcess	response to fungicide	KDM5B KDM1A	1.93e-04	8	55	2	GO:0060992
GeneOntologyBiologicalProcess	detection of stimulus involved in sensory perception of pain	HTR2A TRPA1 GRIN2A	2.05e-04	43	55	3	GO:0062149
GeneOntologyCellularComponent	eukaryotic translation initiation factor 3 complex, eIF3m	EIF3C EIF3CL	2.42e-04	9	55	2	GO:0071541
Domain	EIF3C_N_dom	EIF3C EIF3CL	8.51e-06	2	55	2	IPR008905
Domain	eIF-3c_N	EIF3C EIF3CL	8.51e-06	2	55	2	PF05470
Domain	EIF3C	EIF3C EIF3CL	8.51e-06	2	55	2	IPR027516
Domain	PINT	EIF3C EIF3CL	9.95e-04	16	55	2	SM00088
Domain	PCI_dom	EIF3C EIF3CL	1.13e-03	17	55	2	IPR000717
Domain	PCI	EIF3C EIF3CL	1.13e-03	17	55	2	PF01399
Domain	-	RECQL EIF3C KDM1A EIF3CL	3.87e-03	218	55	4	1.10.10.10
Domain	RAS	RALB GEM	4.76e-03	35	55	2	PS51421
Domain	Small_GTPase_Ras	RALB GEM	5.31e-03	37	55	2	IPR020849
Domain	WHTH_DNA-bd_dom	RECQL EIF3C KDM1A EIF3CL	5.59e-03	242	55	4	IPR011991
Pubmed	Mouse mutants in schizophrenia risk genes GRIN2A and AKAP11 show EEG abnormalities in common with schizophrenia patients.	AKAP11 GRIN2A	2.64e-06	2	57	2	36914641
Pubmed	EIF3C Promotes Lung Cancer Tumorigenesis by Regulating the APP/HSPA1A/LMNB1 Axis.	EIF3C EIF3CL	2.64e-06	2	57	2	36157221
Pubmed	Kdm1a promotes SCLC progression by transcriptionally silencing the tumor suppressor Rest.	REST KDM1A	2.64e-06	2	57	2	31146914
Pubmed	Relationship between PIWIL4-Mediated H3K4me2 Demethylation and piRNA-Dependent DNA Methylation.	KDM5B KDM1A	7.91e-06	3	57	2	30304676
Pubmed	Hypoxia Promotes Resistance to EGFR Inhibition in NSCLC Cells via the Histone Demethylases, LSD1 and PLU-1.	KDM5B KDM1A	7.91e-06	3	57	2	29934325
Pubmed	KIF15 promotes human glioblastoma progression under the synergistic transactivation of REST and P300.	KIF15 REST	7.91e-06	3	57	2	39430242
Pubmed	A comparison of the rest complex binding patterns in embryonic stem cells and epiblast stem cells.	REST KDM1A	7.91e-06	3	57	2	24752154
Pubmed	Grainyhead 1 acts as a drug-inducible conserved transcriptional regulator linked to insulin signaling and lifespan.	GRHL1 KDM1A	1.58e-05	4	57	2	35013237
Pubmed	Prion protein is essential for the RE1 silencing transcription factor (REST)-dependent developmental switch in synaptic NMDA receptors.	GRIN2A REST	1.58e-05	4	57	2	29748616
Pubmed	Interaction between the Ret finger protein and the Int-6 gene product and co-localisation into nuclear bodies.	EIF3C EIF3CL	1.58e-05	4	57	2	10504338
Pubmed	Tagging genes with cassette-exchange sites.	KDM5B EIF3C REST KDM1A EIF3CL MSI2	1.83e-05	335	57	6	15741177
Pubmed	Multiplexed barcoded CRISPR-Cas9 screening enabled by CombiGEM.	KDM5B NSD1 KDM1A	2.20e-05	33	57	3	26864203
Pubmed	Small CTD phosphatases function in silencing neuronal gene expression.	GRIN2A REST	2.63e-05	5	57	2	15681389
Pubmed	Phosphorylation of histone H3T6 by PKCbeta(I) controls demethylation at histone H3K4.	KDM5B KDM1A	3.94e-05	6	57	2	20228790
Pubmed	The ZNF217 oncogene is a candidate organizer of repressive histone modifiers.	KDM5B KDM1A	3.94e-05	6	57	2	19242095
Pubmed	An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.	RALB TXLNA PTPN13 EDC3 NUFIP2 RANBP9 SPAG16 ARPC3 KDM1A EIF3CL	5.13e-05	1321	57	10	27173435
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	KDM5B PTPN13 KIF15 RBBP8 KDM1A S100PBP	6.29e-05	418	57	6	34709266
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	TTBK2 PTPN13 EDC3 VPS33B ALDH1L2 AKNAD1 NSD1 CPLANE1 POLK	6.30e-05	1084	57	9	11544199
Pubmed	Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes.	TXLNA NUFIP2 RANBP9 ANKRD26 SGO2 RECQL KDM1A	8.64e-05	645	57	7	25281560
Pubmed	Identification of proximal SUMO-dependent interactors using SUMO-ID.	PMS1 EDC3 NUFIP2 RECQL EIF3C POLK	8.76e-05	444	57	6	34795231
Pubmed	The pleiotropic mouse phenotype extra-toes spotting is caused by translation initiation factor Eif3c mutations and is associated with disrupted sonic hedgehog signaling.	EIF3C EIF3CL	9.43e-05	9	57	2	21292980
Pubmed	The m subunit of murine translation initiation factor eIF3 maintains the integrity of the eIF3 complex and is required for embryonic development, homeostasis, and organ size control.	EIF3C EIF3CL	9.43e-05	9	57	2	24003236
Pubmed	Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity.	TXLNA NUFIP2 AKAP11 EIF3C ACVR1B CPLANE1 EIF3CL MSI2	1.13e-04	910	57	8	36736316
Pubmed	New nomenclature for chromatin-modifying enzymes.	KDM5B NSD1 KDM1A	1.15e-04	57	57	3	18022353
Pubmed	mTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events.	EIF3C EIF3CL	1.18e-04	10	57	2	16286006
Pubmed	Conservation and diversity of eukaryotic translation initiation factor eIF3.	EIF3C EIF3CL	1.18e-04	10	57	2	8995409
Pubmed	Polymorphism discovery in 62 DNA repair genes and haplotype associations with risks for lung and head and neck cancers.	PMS1 POLK	1.18e-04	10	57	2	17494052
Pubmed	Translational isoforms of FOG1 regulate GATA1-interacting complexes.	RBBP8 KDM1A	1.44e-04	11	57	2	19654328
Pubmed	KAP1 facilitates reinstatement of heterochromatin after DNA replication.	VPS33B CEBPZ RECQL EIF3C ARPC3 KDM1A MSI2	1.48e-04	704	57	7	29955894
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	TXLNA KIF15 NUFIP2 RANBP9 NSD1 GRIN2A ARPC3 KDM1A	1.67e-04	963	57	8	28671696
Pubmed	Characterization of eIF3k: a newly discovered subunit of mammalian translation initiation factor elF3.	EIF3C EIF3CL	1.72e-04	12	57	2	14519125
Pubmed	Reconstitution reveals the functional core of mammalian eIF3.	EIF3C EIF3CL	1.72e-04	12	57	2	17581632
Pubmed	Binding of the JmjC demethylase JARID1B to LSD1/NuRD suppresses angiogenesis and metastasis in breast cancer cells by repressing chemokine CCL14.	KDM5B KDM1A	1.72e-04	12	57	2	21937684
Pubmed	Proximity interactions of the ubiquitin ligase Mind bomb 1 reveal a role in regulation of epithelial polarity complex proteins.	PTPN13 NUFIP2 ANKRD26 EIF3CL	1.74e-04	169	57	4	31462741
Pubmed	A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.	TXLNA PTPN13 EDC3 CEBPZ NUFIP2 ANKRD26 RECQL	1.76e-04	724	57	7	36232890
Pubmed	Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers.	BRDT NSD1 EIF3C CPM ACVR1B KDM1A EIF3CL	1.85e-04	730	57	7	34857952
Pubmed	ZNF198 stabilizes the LSD1-CoREST-HDAC1 complex on chromatin through its MYM-type zinc fingers.	REST KDM1A	2.03e-04	13	57	2	18806873
Pubmed	Evidence for complex multigenic inheritance of radiation AML susceptibility in mice revealed using a surrogate phenotypic assay.	RBBP8 NSD1	2.03e-04	13	57	2	16093251
Pubmed	Dynamic patterns of histone H3 lysine 4 methyltransferases and demethylases during mouse preimplantation development.	KDM5B KDM1A	2.03e-04	13	57	2	24619213
Pubmed	Mass spectrometry reveals modularity and a complete subunit interaction map of the eukaryotic translation factor eIF3.	EIF3C EIF3CL	2.37e-04	14	57	2	18599441
Pubmed	Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations.	RIMS3 NUFIP2 GRIN2A EIF3C EIF3CL	2.63e-04	347	57	5	17114649
Pubmed	Comprehensive Protein Interactome Analysis of a Key RNA Helicase: Detection of Novel Stress Granule Proteins.	EDC3 NUFIP2	2.73e-04	15	57	2	26184334
Pubmed	Structural characterization of the human eukaryotic initiation factor 3 protein complex by mass spectrometry.	EIF3C EIF3CL	2.73e-04	15	57	2	17322308
Pubmed	The deubiquitylase USP33 discriminates between RALB functions in autophagy and innate immune response.	RALB USP33	2.73e-04	15	57	2	24056301
Pubmed	Controlling tissue patterning by translational regulation of signaling transcripts through the core translation factor eIF3c.	EIF3C EIF3CL	3.53e-04	17	57	2	34752747
Pubmed	Wilms Tumor Predisposition	NSD1 REST	3.97e-04	18	57	2	20301471
Pubmed	Broad histone H3K4me3 domains in mouse oocytes modulate maternal-to-zygotic transition.	KDM5B KDM1A	5.43e-04	21	57	2	27626377
Pubmed	Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	ANKRD26 MINAR1 USP33	6.76e-04	104	57	3	10470851
Pubmed	siRNA screening identifies differences in the Fanconi anemia pathway in BALB/c-Trp53+/- with susceptibility versus C57BL/6-Trp53+/- mice with resistance to mammary tumors.	RECQL POLK	8.36e-04	26	57	2	23435420
Pubmed	Genetic loci influencing natural variations in femoral bone morphometry in mice.	EIF3C EIF3CL	9.02e-04	27	57	2	11518254
Pubmed	Candidate gene analysis in an on-going genome-wide association study of attention-deficit hyperactivity disorder: suggestive association signals in ADRA1A.	HTR2A GRIN2A	9.71e-04	28	57	2	19352218
Pubmed	Identification of proteins that interact with alpha A-crystallin using a human proteome microarray.	CEBPZ OTOGL ALDH1L2	9.75e-04	118	57	3	24453475
Pubmed	Unbiased Identification of trans Regulators of ADAR and A-to-I RNA Editing.	CEBPZ EIF3C KDM1A EIF3CL	1.03e-03	271	57	4	32433965
Pubmed	The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells.	RANBP9 SGO2 AKAP11 MSI2	1.19e-03	282	57	4	23667531
Pubmed	Substrate trapping proteomics reveals targets of the βTrCP2/FBXW11 ubiquitin ligase.	KDM5B PTPN13 REST	1.23e-03	128	57	3	25332235
Pubmed	C5orf51 is a component of the MON1-CCZ1 complex and controls RAB7A localization and stability during mitophagy.	PTPN13 VPS33B AKAP11 EIF3C USP33	1.41e-03	504	57	5	34432599
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	PMS1 PTPN13 KIF15 VPS33B CEBPZ NUFIP2 EIF3C	1.58e-03	1049	57	7	27880917
Pubmed	Global phosphoproteome analysis on human HepG2 hepatocytes using reversed-phase diagonal LC.	EIF3C EIF3CL	1.60e-03	36	57	2	16097034
Pubmed	Endogenous human MDM2-C is highly expressed in human cancers and functions as a p53-independent growth activator.	RBBP8 RECQL	1.60e-03	36	57	2	24147044
Cytoband	5p13.2	RANBP3L CPLANE1	6.88e-04	31	57	2	5p13.2
Cytoband	1p35.1	TXLNA S100PBP	7.33e-04	32	57	2	1p35.1
GeneFamily	PHD finger proteins\|Lysine demethylases	KDM5B KDM1A	8.17e-04	24	32	2	485
GeneFamily	Ankyrin repeat domain containing	ANKRD31 TRPA1 ANKRD26	8.82e-03	242	32	3	403
GeneFamily	PHD finger proteins	KDM5B NSD1	1.10e-02	90	32	2	88
Coexpression	GSE37301_PRO_BCELL_VS_GRANULOCYTE_MONOCYTE_PROGENITOR_DN	RALB TTBK2 PTPN13 HTR2A POLK PROS1	2.00e-06	175	56	6	M8892
Coexpression	HAMAI_APOPTOSIS_VIA_TRAIL_UP	PTPN13 KIF15 CEBPZ RBBP8 RECQL AKAP11 CPLANE1 POLK PROS1	9.67e-06	656	56	9	M18979
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PTPN13 RBBP8 CPM SPAG16 MSI2 CCDC148	1.80e-07	194	57	6	5eaaa81f4b2535f983c424aaef00077089526a5c
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	RANBP3L RBBP8 CPM MSI2 CCDC148	4.46e-06	190	57	5	bf4511395fa97efd1c1cd17cc9bebb0271ee7f0e
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	RANBP3L RBBP8 CPM MSI2 CCDC148	4.46e-06	190	57	5	b6b8964b4910083499681b5fdf554e127b6a4c4e
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	PTPN13 RBBP8 SPAG16 MSI2 CCDC148	5.07e-06	195	57	5	6477e6e7be5bd8eb99119a12ae16334ccddecd43
ToppCell	COVID-19-kidney-TAL\|kidney / Disease (COVID-19 only), tissue and cell type	RANBP3L RBBP8 CPM MSI2 CCDC148	5.19e-06	196	57	5	04f5eb206ed3016a737609a3ebac0c1fcabb94ef
ToppCell	367C-Lymphocytic-CD4_T-cell-Treg_cell_2\|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)	RBBP8 TMEM108 SPAG16 GEM	4.53e-05	154	57	4	9200e2f1783e54cbc5dfc3b485b57c761af74a46
ToppCell	367C-Lymphocytic-CD4_T-cell-Treg_cell_2\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	RBBP8 TMEM108 SPAG16 GEM	4.53e-05	154	57	4	b16f3139ce50e70a6a2377b1da7d7877b4000ea1
ToppCell	10x5'-Liver-Lymphocytic_T_CD4-Tfh\|Liver / Manually curated celltypes from each tissue	PTPN13 RIMS3 ANKRD26 CCDC148	4.76e-05	156	57	4	85bc34ff507f9a66c6e3ba7a3ffd5416d0073ccf
ToppCell	Adult-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)-D231\|Adult / Lineage, Cell type, age group and donor	GRHL1 PTPN13 RANBP9 TMEM108	6.65e-05	170	57	4	269dee5abca9f6aa079f116f0d8f1d198604d9d4
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	GRHL1 PTPN13 TMEM108 CPM	6.65e-05	170	57	4	a2c738e441ced90eeeb1fcc6ca3269b918aaa298
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	KIAA0408 ITGBL1 GRIN2A GEM	6.96e-05	172	57	4	1ef243bce63d841c25e4b74d029d1377f84bcc3d
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	KIAA0408 ITGBL1 GRIN2A GEM	6.96e-05	172	57	4	ab1c81be29f93ca8920c6ab5ab92f497a9256d3f
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)\|Children_(3_yrs) / Lineage, Cell type, age group and donor	GRHL1 PTPN13 TMEM108 CPM	9.22e-05	185	57	4	98b8ee42b89d97e4c9db01740e0c193503c68f2c
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Cortical_Thick_Ascending_Limb_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	RANBP3L CPM MSI2 CCDC148	9.61e-05	187	57	4	b93cf4dfe8ffb89348ee7bccc9f284189f7240a2
ToppCell	COVID-19-kidney-Mito-rich_Distal\|kidney / Disease (COVID-19 only), tissue and cell type	RANBP3L CPM MSI2 CCDC148	9.61e-05	187	57	4	2ce8038d9d1302e850c1bb536e755598f77ba4b9
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	RBBP8 CPM SPAG16 CCDC148	9.81e-05	188	57	4	af740fa78542438fdff627ea1f74f4eee43316be
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	RANBP3L TMEM108 MSI2 CCDC148	9.81e-05	188	57	4	bc089cd73d283ed7d2ecbb3936673b4edc89f666
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	RBBP8 TMEM108 MSI2 CCDC148	1.00e-04	189	57	4	7eb8f5a951e80f1cfac4d7c9eb169f4eb100c917
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	RBBP8 TMEM108 MSI2 CCDC148	1.00e-04	189	57	4	975c0f079903ae36b0ffa54e86294d42ec7697de
ToppCell	droplet-Tongue-nan-24m-Epithelial-filiform\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GRHL1 UNC5B AKNAD1 CPM	1.02e-04	190	57	4	86ab845a7fae2111c0b01e1aec235e19c4c0ef5c
ToppCell	COVID-19-kidney-TAL\|COVID-19 / Disease (COVID-19 only), tissue and cell type	RANBP3L RBBP8 MSI2 CCDC148	1.04e-04	191	57	4	fe55475ce0666ab5122447a813dc2369e24947b8
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Cortical_Thick_Ascending_Limb_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	RANBP3L CPM MSI2 CCDC148	1.04e-04	191	57	4	963f4f2e852bbb4faf070aafb0d368297abacd3b
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	RBBP8 CPM MSI2 CCDC148	1.04e-04	191	57	4	2fa1b9e76a0ed2d2f0de74349e266cf4a5f51aad
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_C_(IT_L4_RORB)-Exc_L4_RORB_BHLHE22\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	RALB HTR2A RIMS3 GRIN2A	1.06e-04	192	57	4	25460ca9ebd3d49f666394cf99ab77a5e8f77250
ToppCell	droplet-Marrow-nan-3m-Myeloid-granulocytopoietic_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KIF15 TMEM108 CPM GEM	1.11e-04	194	57	4	8ef0b71fef5b84cfd04973f891215333e7035d1d
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PTPN13 RBBP8 SPAG16 CCDC148	1.11e-04	194	57	4	93c68c31e39fa44c1d05d7d4997f4f086da4e738
ToppCell	facs-Marrow-B-cells-3m-Lymphocytic-late_pro_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KIF15 SGO2 TMEM108 CPM	1.13e-04	195	57	4	5749ea833be84e262e3d0a4fe1a9a373f0ef545f
ToppCell	facs-Marrow-B-cells-3m-Lymphocytic-late_pro-B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KIF15 SGO2 TMEM108 CPM	1.13e-04	195	57	4	294c74336fafc1bad237d851efb4a487475078eb
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PTPN13 SPAG16 MSI2 CCDC148	1.15e-04	196	57	4	6ce74aa3f0ce3ca284b67e5a4660ffd2cc9611e0
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PTPN13 RBBP8 SPAG16 CCDC148	1.17e-04	197	57	4	7e93a97b5ac5ae2f77a4b3141082a1463fed00dd
ToppCell	facs-Diaphragm-Limb_Muscle-3m\|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NUFIP2 SKIL GEM PROS1	1.17e-04	197	57	4	b0e2ea81308bce289cb7cbea0e27de1d01afeed2
ToppCell	Parenchymal-NucSeq-Epithelial-Epi_airway_secretory-Secretory_Club\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	GRHL1 PTPN13 TMEM108 MSI2	1.20e-04	198	57	4	1408e02e053ad3406229bfe8189da03be6366e81
ToppCell	Parenchymal-NucSeq-Epithelial-Epi_airway_secretory\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	GRHL1 PTPN13 TMEM108 MSI2	1.20e-04	198	57	4	af399569c718f5fd971d73a7926768c9311002a3
ToppCell	(10)_Ciliated-(2)_GFP_FOXI1\|(10)_Ciliated / shred by cell type by condition	ANKRD26 REST PROS1 BBOF1	1.22e-04	199	57	4	61b1ed2db71b96157b92b7535d1955a4033098da
Disease	pain	VPS33B RBBP8 SPATA16 NUFIP2 NSD1 REST	1.76e-06	196	55	6	EFO_0003843
Disease	total cholesterol measurement, hematocrit, stroke, ventricular rate measurement, body mass index, atrial fibrillation, high density lipoprotein cholesterol measurement, coronary artery disease, diastolic blood pressure, triglyceride measurement, systolic blood pressure, heart failure, diabetes mellitus, glucose measurement, mortality, cancer	ANKRD31 GRHL1 ANKRD26 POLK	8.53e-06	69	55	4	EFO_0000275, EFO_0000400, EFO_0000712, EFO_0001645, EFO_0003144, EFO_0004340, EFO_0004348, EFO_0004352, EFO_0004468, EFO_0004530, EFO_0004574, EFO_0004612, EFO_0006335, EFO_0006336, EFO_0007928, MONDO_0004992
Disease	reading and spelling ability	PTPN13 UNC5B CPM MSI2	2.63e-04	166	55	4	EFO_0005301
Disease	schizophrenia (biomarker_via_orthology)	HTR2A KDM1A	3.53e-04	15	55	2	DOID:5419 (biomarker_via_orthology)
Disease	X-12063 measurement	HTR2A OTOGL ANKRD26 GEM	4.06e-04	186	55	4	EFO_0021283
Disease	heart failure, diabetes mellitus, stroke, atrial fibrillation, mortality, coronary artery disease, cancer	GRHL1 ANKRD26	6.34e-04	20	55	2	EFO_0000275, EFO_0000400, EFO_0000712, EFO_0001645, EFO_0003144, EFO_0004352, MONDO_0004992
Disease	response to peginterferon alfa-2a	ANKRD26 MSI2	9.96e-04	25	55	2	EFO_0010103
Disease	ganglion cell inner plexiform layer thickness measurement	CCDC148 BBOF1	1.25e-03	28	55	2	EFO_0600005
Disease	Autistic Disorder	KDM5B HTR2A NSD1 GRIN2A	1.43e-03	261	55	4	C0004352

Protein segments in the cluster

Peptide	Gene	Start	Entry
SMLAKDKKKQQELCA	CCDC148	351	Q8NFR7
LKMKKQEQKGEKSSN	RBBP8	701	Q99708
SPSKENVKKMKNECI	BRDT	681	Q58F21
LKSKNILVKKNGMCA	ACVR1B	336	P36896
GKQIMKSCAVSNLKK	ALDH1L2	676	Q3SY69
MGQKKNSKQDAKTTD	HTR2A	426	P28223
GNLDQKNKSKNKSLM	AKAP11	531	Q9UKA4
SMKTVQKKCEKLQKN	ANKRD26	1436	Q9UPS8
AKSNEDLKKKQCKME	BBOF1	61	Q8ND07
RDCGKNTANKKMLKD	RANBP9	636	Q96S59
MSENKDKNGKKSSKN	RALB	181	P11234
NNKMVECKKAQPKEV	MSI2	176	Q96DH6
MQCKKVKNDDSSKEI	NSD1	1481	Q96L73
KNNKNMAFKLKSKSC	GEM	276	P55040
KNEQFSGKKEKMKVN	ANKRD31	461	Q8N7Z5
GDSKVEENKKQNTCM	REST	561	Q13127
EENKKQNTCMKKSTK	REST	566	Q13127
EKQKETAKCEQQMAK	KIF15	941	Q9NS87
NQMCKEQKATKKSKV	KIAA0408	116	Q6ZU52
KCENEKEMKSSIKQE	KDM5B	266	Q9UGL1
KSGLKNGQMKNKDDE	EDC3	176	Q96F86
GKKKMNKNNAKALST	EIF3C	126	Q99613
GKKKMNKNNAKALST	EIF3CL	126	B5ME19
KKCKKGILVNMDDNI	GRHL1	576	Q9NZI5
SKQVNMELAKIKQKC	KDM1A	346	O60341
SRNPNMKKGDECKNK	CPM	231	P14384
MKKGDECKNKMNFPN	CPM	236	P14384
KRKMCNQKENPTKKE	CPLANE1	1511	Q9H799
KLQKCNSKSQGEKEM	ARPC3	81	O15145
FQKISQGKQMCQKLK	AKNAD1	371	Q5T1N1
AKMEKINEKASDKCG	ASNSD1	611	Q9NWL6
NKQDVLNKDSGKMKG	S100PBP	276	Q96BU1
NCDLTKKKSNQMCKN	ITGBL1	131	O95965
KKKSNQMCKNSQDII	ITGBL1	136	O95965
CNKKSNVIDNKSGKV	PMS1	546	P54277
NLVKKKGSKQQCLMA	CEBPZ	271	Q03701
KCSMNQNGNSLKKLA	OTOGL	1576	Q3ZCN5
DENEMSDKSKKQCKS	PTPN13	1631	Q12923
TANENKKTICTKGKN	MUCL3	311	Q3MIW9
KDKMKCTVNNQQSKK	MINAR1	66	Q9UPX6
MKQKCTCDSNLEKDK	SKIL	611	P12757
YQKKLKEGTCKAQEM	SPATA21	336	Q7Z572
ENGACLAKKKTKMTK	RIMS3	201	Q9UJD0
KEKMQCDNNIKSKTL	SGO2	171	Q562F6
LEMSQEIKKNCGGKQ	SPATA16	41	Q9BXB7
CKNGFVMLSNKKDCK	PROS1	186	P07225
GDKKMEEKNSGNFQK	RECQL	611	P46063
NKQKKLKRCDDMDTF	TRPA1	51	O75762
TKNFIQKNSMDKKNG	NUFIP2	151	Q7Z417
CKTKEKTNNKISEGN	RANBP3L	151	Q86VV4
NKMKSPCESNKRKVD	SPANXN4	11	Q5MJ08
EQNKCKTKMKGNTKD	SPAG16	301	Q8N0X2
MDANKNKIKLGICKA	TTBK2	386	Q6IQ55
NTMLAKVCSDKNKPN	POLK	316	Q9UBT6
KNCTDGLCMQNKKTL	UNC5B	346	Q8IZJ1
GACESIMKKKTKQDF	VPS33B	346	Q9H267
EKMCNKINKVNSEGE	USP33	366	Q8TEY7
MKNQDKKNGAAKQSN	TXLNA	1	P40222
CMKRKKKTANPENNL	TMEM108	491	Q6UXF1
KINNSTNEGMNVKKC	GRIN2A	441	Q12879