Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionlysine-acetylated histone binding

ZZEF1 BRD9

6.41e-0430252GO:0070577
GeneOntologyMolecularFunctionacetylation-dependent protein binding

ZZEF1 BRD9

6.84e-0431252GO:0140033
GeneOntologyMolecularFunctionvoltage-gated monoatomic cation channel activity

KCNK5 CACNG8 RYR1

8.80e-04152253GO:0022843
GeneOntologyMolecularFunctionFAD binding

KDM1B ACOXL

1.38e-0344252GO:0071949
GeneOntologyMolecularFunctionvoltage-gated monoatomic ion channel activity

KCNK5 CACNG8 RYR1

1.48e-03182253GO:0005244
GeneOntologyMolecularFunctionvoltage-gated calcium channel activity

CACNG8 RYR1

1.51e-0346252GO:0005245
GeneOntologyMolecularFunctionvoltage-gated channel activity

KCNK5 CACNG8 RYR1

1.52e-03184253GO:0022832
GeneOntologyCellularComponentsarcolemma

CACNG8 DMD FER1L5 RYR1

7.20e-05190254GO:0042383
GeneOntologyCellularComponentT-tubule

CACNG8 FER1L5 RYR1

1.13e-0479253GO:0030315
HumanPhenoAbnormal thrombosis

IDH2 DMD F5 RYR1

1.36e-0521054HP:0001977
HumanPhenoThromboembolism

IDH2 DMD F5 RYR1

1.36e-0521054HP:0001907
HumanPhenoAbnormality of urine homeostasis

IDH2 DMD PIK3C2A F5 RYR1

9.63e-0580355HP:0003110
HumanPhenoExercise-induced muscle cramps

DMD RYR1

1.04e-041752HP:0003710
HumanPhenoThoracic kyphosis

DMD PIK3C2A RYR1

1.14e-0411753HP:0002942
HumanPhenoAbnormal venous morphology

IDH2 DMD F5 RYR1

1.18e-0436254HP:0002624
HumanPhenoAbnormal thoracic spine morphology

DMD PIK3C2A RYR1

1.20e-0411953HP:0100711
HumanPhenoHepatic encephalopathy

F5 RYR1

2.11e-042452HP:0002480
HumanPhenoLimitation of joint mobility

IDH2 DMD PIK3C2A RYR1

2.38e-0443254HP:0001376
HumanPhenoMyoglobinuria

DMD RYR1

3.54e-043152HP:0002913
HumanPhenoAcute hepatic failure

F5 RYR1

4.53e-043552HP:0006554
HumanPhenoAbnormality of the urinary system physiology

IDH2 DMD PIK3C2A F5 RYR1

7.18e-04119955HP:0011277
HumanPhenoAbnormal blood vessel morphology

IDH2 DMD PIK3C2A F5 RYR1

7.24e-04120155HP:0033353
HumanPhenoSkeletal muscle hypertrophy

DMD PIK3C2A RYR1

7.35e-0421953HP:0003712
HumanPhenoMiscarriage

F5 RYR1

7.50e-044552HP:0005268
HumanPhenoHyperlordosis

DMD PIK3C2A RYR1

7.65e-0422253HP:0003307
HumanPhenoLordosis

DMD PIK3C2A RYR1

7.65e-0422253HP:0002939
HumanPhenoCalf muscle hypertrophy

DMD RYR1

9.27e-045052HP:0008981
HumanPhenoMuscle hypertrophy of the lower extremities

DMD RYR1

1.04e-035352HP:0008968
HumanPhenoAbnormal vascular morphology

IDH2 DMD PIK3C2A F5 RYR1

1.16e-03131955HP:0025015
HumanPhenoAbnormal urine metabolite level

IDH2 DMD PIK3C2A RYR1

1.16e-0364754HP:0033354
HumanPhenoAbnormality of thrombocytes

IDH2 DMD F5 RYR1

1.53e-0369554HP:0001872
DomainZF_ZZ_2

DMD ZZEF1

2.39e-0418242PS50135
DomainZF_ZZ_1

DMD ZZEF1

2.39e-0418242PS01357
DomainZZ

DMD ZZEF1

2.39e-0418242PF00569
DomainZnf_ZZ

DMD ZZEF1

2.67e-0419242IPR000433
DomainZnF_ZZ

DMD ZZEF1

2.67e-0419242SM00291
DomainTPR_2

LRP2BP TTC14

1.87e-0350242PF07719
DomainTPR_2

LRP2BP TTC14

1.87e-0350242IPR013105
Domain-

PRPF39 LRP2BP TTC14

2.29e-032072431.25.40.10
DomainTPR-like_helical_dom

PRPF39 LRP2BP TTC14

3.20e-03233243IPR011990
Domain-

ZZEF1 F5

3.93e-03732422.60.120.260
Domain-

DMD ZZEF1 RYR1

4.39e-032612431.10.238.10
DomainEF-hand-dom_pair

DMD ZZEF1 RYR1

5.72e-03287243IPR011992
DomainGalactose-bd-like

ZZEF1 F5

6.44e-0394242IPR008979
PathwayREACTOME_MUSCLE_CONTRACTION

KCNK5 CACNG8 DMD RYR1

3.82e-05165174MM15026
PathwayREACTOME_MUSCLE_CONTRACTION

KCNK5 CACNG8 DMD RYR1

8.58e-05203174M5485
PathwayREACTOME_LGI_ADAM_INTERACTIONS

CACNG8 LGI2

1.24e-0414172MM15277
PathwayREACTOME_LGI_ADAM_INTERACTIONS

CACNG8 LGI2

1.24e-0414172M27564
PathwayREACTOME_CARDIAC_CONDUCTION

KCNK5 CACNG8 RYR1

2.39e-04103173MM15196
PathwayREACTOME_CARDIAC_CONDUCTION

KCNK5 CACNG8 RYR1

4.74e-04130173M27454
Pubmed

Hypernitrosylated ryanodine receptor calcium release channels are leaky in dystrophic muscle.

DMD RYR1

2.97e-06425219198614
Pubmed

iNOS is not responsible for RyR1 S-nitrosylation in mdx mice with truncated dystrophin.

DMD RYR1

2.97e-06425232693782
Pubmed

STIM1 signalling controls store-operated calcium entry required for development and contractile function in skeletal muscle.

DMD RYR1

2.97e-06425218488020
Pubmed

Nox4 - RyR1 - Nox2: Regulators of micro-domain signaling in skeletal muscle.

DMD RYR1

1.04e-05725232506037
Pubmed

AAV-mediated intramuscular delivery of myotubularin corrects the myotubular myopathy phenotype in targeted murine muscle and suggests a function in plasma membrane homeostasis.

DMD RYR1

2.22e-051025218434328
Pubmed

BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression.

PPP4R3B IDH2 TIMM44 PRPF39 FUBP3 NKAPD1 BRD9

2.91e-05131825730463901
Pubmed

Multiple loci influencing hippocampal degeneration identified by genome scan.

METTL8 F5

3.85e-051325222745009
Pubmed

Prokineticin receptor-1 signaling promotes Epicardial to Mesenchymal Transition during heart development.

DMD RYR1

1.03e-042125227150455
Pubmed

KAP1 facilitates reinstatement of heterochromatin after DNA replication.

UTP20 IDH2 TIMM44 PRPF39 FUBP3

1.27e-0470425529955894
Pubmed

FBXO32 links ubiquitination to epigenetic reprograming of melanoma cells.

UTP20 TIMM44 FUBP3

4.65e-0421225333462405
CytobandEnsembl 112 genes in cytogenetic band chr2p16

PPP4R3B GTF2A1L

1.99e-03121252chr2p16
GeneFamilyZinc fingers ZZ-type|Lysine acetyltransferases

DMD ZZEF1

5.12e-051811291
CoexpressionGSE16450_IMMATURE_VS_MATURE_NEURON_CELL_LINE_DN

KCNK5 UTP20 TIMM44 F5

3.53e-05198254M7401
CoexpressionGSE5542_IFNG_VS_IFNA_AND_IFNG_TREATED_EPITHELIAL_CELLS_6H_DN

KCNK5 UTP20 IDH2 PRPF39

3.67e-05200254M6533
CoexpressionYAO_HOXA10_TARGETS_VIA_PROGESTERONE_UP

IDH2 PRPF39 TTC14

6.70e-0583253M10660
CoexpressionYAO_HOXA10_TARGETS_VIA_PROGESTERONE_UP

IDH2 PRPF39 TTC14

8.81e-0591253MM622
ToppCellT_cells-TFH-like_cells|T_cells / Immune cells in Kidney/Urine in Lupus Nephritis

KCNK5 METTL8 PIK3C2A F5

2.81e-06178254e2ae43e5ec31de6197f2cbd6089f944adbf0a163
Drugthiopental

DMD GTF2A1L PIK3C2A RYR1

6.48e-06112254CID003000715
Drugisoflurane

KCNK5 DMD ZZEF1 PIK3C2A RYR1

1.16e-05279255CID000003763
Drugtiapamil

DMD PIK3C2A

1.73e-056252CID000042106
DrugDantrolene-13C3

CACNG8 DMD PIK3C2A RYR1

1.80e-05145254CID000002951
Druglidocaine

KCNK5 DMD PIK3C2A RYR1

2.65e-05160254CID000003676
DrugBAPNA

DMD PIK3C2A RYR1

3.29e-0557253CID000013494
Drugsuccinylcholine

DMD PIK3C2A RYR1

4.66e-0564253CID000005314
Drugpropofol

DMD GTF2A1L PIK3C2A RYR1

5.29e-05191254CID000004943
DrugTrichostatin A, Streptomyces sp.; Down 200; 0.1uM; HL60; HT_HG-U133A

KCNK5 IDH2 TIMM44 BRD9

5.40e-051922541153_DN
DrugGabazine [105538-73-6]; Up 200; 10.8uM; MCF7; HT_HG-U133A

ZZEF1 F5 RYR1 ACOXL

6.32e-052002544820_UP
DrugAC1L9E9N

GTF2A1L F5

8.96e-0513252CID000443225
Diseasedilated cardiomyopathy (is_marker_for)

CACNG8 DMD

3.52e-0439212DOID:12930 (is_marker_for)
Diseasehippocampal atrophy

METTL8 F5

7.26e-0456212EFO_0005039
DiseasePetit mal status

KCNK5 DMD

1.04e-0367212C0270823
DiseaseStatus Epilepticus, Subclinical

KCNK5 DMD

1.04e-0367212C0751522
DiseaseSimple Partial Status Epilepticus

KCNK5 DMD

1.04e-0367212C0751524
DiseaseNon-Convulsive Status Epilepticus

KCNK5 DMD

1.04e-0367212C0751523
DiseaseGrand Mal Status Epilepticus

KCNK5 DMD

1.04e-0367212C0311335
DiseaseComplex Partial Status Epilepticus

KCNK5 DMD

1.04e-0367212C0393734
DiseaseStatus Epilepticus

KCNK5 DMD

1.07e-0368212C0038220
DiseaseCardiac Hypertrophy

IDH2 DMD

1.55e-0382212C1383860
DiseaseCardiomegaly

IDH2 DMD

1.55e-0382212C0018800

Protein segments in the cluster

PeptideGeneStartEntry
KKHKAEWRSSYEDYA

BRD9

6

Q9H8M2
WEHAKYKWYLKELQD

DMD

2136

P11532
YKVKTKKEDFFHAWN

ACOXL

456

Q9NUZ1
WKEAKKNYYTQKLHL

KCNK5

31

O95279
DKAFLWEKRYYCFKH

PIK3C2A

891

O00443
YSKAWEDYYKKQSHA

FUBP3

516

Q96I24
KFFQWKKEKTDYTHA

LRP2BP

26

Q9P2M1
KCEKDFFLKHYRYSW

PPP4R3B

486

Q5MIZ7
YWKKYADLEKRHDNI

PRPF39

131

Q86UA1
KRDEEKKNHYSYGWS

CACNG8

191

Q8WXS5
DKHYKTDFDKNKIWY

IDH2

271

P48735
RSHKDGYDKYTTWKK

KDM1B

101

Q8NB78
NKFAEYTHEKWAFDK

RYR1

2756

P21817
SKYWDTFYKIHKNKF

METTL8

86

Q9H825
ENKQFWKVYYEHLEK

UTP20

751

O75691
FDEKKSWYYEKKSRS

F5

1776

P12259
LFWATDEHKSLKYKY

FER1L5

1391

A0AVI2
HIYKYDESWTKFVKF

LGI2

301

Q8N0V4
YHAYNGWKKKYLETK

SPATA1

336

Q5VX52
DFLKAKSWNKKFYDY

NKAPD1

86

Q6ZUT1
YDKIHRSKNKWKFYL

GTF2A1L

441

Q9UNN4
EYSWKSVEKYKKYAH

TTC14

676

Q96N46
KAFSYKKDQHWKFQT

ZNF658

196

Q5TYW1
HKDSKWYQQWKDFKE

TIMM44

236

O43615
HFKRFEKYDKWKLQE

ZZEF1

616

O43149