Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionvoltage-gated chloride channel activity

CLCN1 CLCN2 CLCN3 CLCN4 CLCN5

1.47e-1111425GO:0005247
GeneOntologyMolecularFunctiontransporter activity

LRRC8A SLC8A2 SLC8A1 CLCN1 CLCN2 PKD1L2 CLCN3 CLCN4 CLCN5 XKR4 LMBRD1 CETP TIMM23B SLC16A14 SCN2A TRPC6 PKD1L1 SCN8A

2.70e-1112894218GO:0005215
GeneOntologyMolecularFunctionvoltage-gated monoatomic anion channel activity

CLCN1 CLCN2 CLCN3 CLCN4 CLCN5

1.95e-1017425GO:0008308
GeneOntologyMolecularFunctionmonoatomic ion channel activity

LRRC8A CLCN1 CLCN2 PKD1L2 CLCN3 CLCN4 CLCN5 SCN2A TRPC6 PKD1L1 SCN8A

1.89e-094594211GO:0005216
GeneOntologyMolecularFunctionmonoatomic ion transmembrane transporter activity

LRRC8A SLC8A2 SLC8A1 CLCN1 CLCN2 PKD1L2 CLCN3 CLCN4 CLCN5 SCN2A TRPC6 PKD1L1 SCN8A

4.87e-097934213GO:0015075
GeneOntologyMolecularFunctiontransmembrane transporter activity

LRRC8A SLC8A2 SLC8A1 CLCN1 CLCN2 PKD1L2 CLCN3 CLCN4 CLCN5 TIMM23B SLC16A14 SCN2A TRPC6 PKD1L1 SCN8A

7.46e-0911804215GO:0022857
GeneOntologyMolecularFunctionchannel activity

LRRC8A CLCN1 CLCN2 PKD1L2 CLCN3 CLCN4 CLCN5 SCN2A TRPC6 PKD1L1 SCN8A

7.65e-095254211GO:0015267
GeneOntologyMolecularFunctionpassive transmembrane transporter activity

LRRC8A CLCN1 CLCN2 PKD1L2 CLCN3 CLCN4 CLCN5 SCN2A TRPC6 PKD1L1 SCN8A

7.81e-095264211GO:0022803
GeneOntologyMolecularFunctioninorganic molecular entity transmembrane transporter activity

SLC8A2 SLC8A1 CLCN1 CLCN2 PKD1L2 CLCN3 CLCN4 CLCN5 SCN2A TRPC6 PKD1L1 SCN8A

3.18e-087584212GO:0015318
GeneOntologyMolecularFunctionmonoatomic anion channel activity

LRRC8A CLCN1 CLCN2 CLCN3 CLCN4 CLCN5

7.34e-08103426GO:0005253
GeneOntologyMolecularFunctionmonoatomic anion transmembrane transporter activity

LRRC8A CLCN1 CLCN2 CLCN3 CLCN4 CLCN5

7.09e-07151426GO:0008509
GeneOntologyMolecularFunctionchloride channel activity

CLCN1 CLCN2 CLCN3 CLCN4 CLCN5

9.89e-0786425GO:0005254
GeneOntologyMolecularFunctionvoltage-gated monoatomic ion channel activity

CLCN1 CLCN2 CLCN3 CLCN4 CLCN5 SCN2A

2.11e-06182426GO:0005244
GeneOntologyMolecularFunctionvoltage-gated channel activity

CLCN1 CLCN2 CLCN3 CLCN4 CLCN5 SCN2A

2.25e-06184426GO:0022832
GeneOntologyMolecularFunctionchloride transmembrane transporter activity

CLCN1 CLCN2 CLCN3 CLCN4 CLCN5

6.27e-06125425GO:0015108
GeneOntologyMolecularFunctionantiporter activity

SLC8A2 SLC8A1 CLCN3 CLCN4 CLCN5

1.02e-05138425GO:0015297
GeneOntologyMolecularFunctioncalcium:monoatomic cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration

SLC8A2 SLC8A1

1.29e-053422GO:1905060
GeneOntologyMolecularFunctioncalcium ion transmembrane transporter activity

SLC8A2 SLC8A1 PKD1L2 TRPC6 PKD1L1

1.57e-05151425GO:0015085
GeneOntologyMolecularFunctioninorganic anion transmembrane transporter activity

CLCN1 CLCN2 CLCN3 CLCN4 CLCN5

2.86e-05171425GO:0015103
GeneOntologyMolecularFunctionsecondary active transmembrane transporter activity

SLC8A2 SLC8A1 CLCN3 CLCN4 CLCN5 SLC16A14

3.38e-05296426GO:0015291
GeneOntologyMolecularFunctionmetal ion transmembrane transporter activity

SLC8A2 SLC8A1 PKD1L2 SCN2A TRPC6 PKD1L1 SCN8A

4.73e-05465427GO:0046873
GeneOntologyMolecularFunctiongated channel activity

CLCN1 CLCN2 CLCN3 CLCN4 CLCN5 SCN2A

6.61e-05334426GO:0022836
GeneOntologyMolecularFunctionvolume-sensitive anion channel activity

LRRC8A CLCN3

1.54e-049422GO:0005225
GeneOntologyMolecularFunctioncalcium:sodium antiporter activity

SLC8A2 SLC8A1

1.92e-0410422GO:0005432
GeneOntologyMolecularFunctioninorganic cation transmembrane transporter activity

SLC8A2 SLC8A1 PKD1L2 SCN2A TRPC6 PKD1L1 SCN8A

3.02e-04627427GO:0022890
GeneOntologyMolecularFunctionclathrin binding

MYCBPAP LMBRD1 TRPC6

3.15e-0463423GO:0030276
GeneOntologyMolecularFunctioncalcium:monoatomic cation antiporter activity

SLC8A2 SLC8A1

3.32e-0413422GO:0015368
GeneOntologyMolecularFunctionsodium ion binding

SCN2A SCN8A

3.87e-0414422GO:0031402
GeneOntologyMolecularFunctionmonoatomic cation transmembrane transporter activity

SLC8A2 SLC8A1 PKD1L2 SCN2A TRPC6 PKD1L1 SCN8A

4.26e-04664427GO:0008324
GeneOntologyMolecularFunctionsodium ion transmembrane transporter activity

SLC8A2 SLC8A1 SCN2A SCN8A

4.51e-04171424GO:0015081
GeneOntologyMolecularFunctionactive transmembrane transporter activity

SLC8A2 SLC8A1 CLCN3 CLCN4 CLCN5 SLC16A14

4.55e-04477426GO:0022804
GeneOntologyMolecularFunctionmonoatomic cation channel activity

PKD1L2 SCN2A TRPC6 PKD1L1 SCN8A

7.33e-04343425GO:0005261
GeneOntologyMolecularFunctioncargo receptor activity

CTAGE9 MIA2 CTAGE8

7.58e-0485423GO:0038024
GeneOntologyMolecularFunctionvoltage-gated sodium channel activity

SCN2A SCN8A

1.36e-0326422GO:0005248
GeneOntologyMolecularFunctionalkali metal ion binding

SCN2A SCN8A

1.36e-0326422GO:0031420
GeneOntologyMolecularFunctioncalcium channel activity

PKD1L2 TRPC6 PKD1L1

2.52e-03129423GO:0005262
GeneOntologyMolecularFunctionprotein transporter activity

LMBRD1 TIMM23B

3.53e-0342422GO:0140318
GeneOntologyMolecularFunctionmetal cation:monoatomic cation antiporter activity

SLC8A2 SLC8A1

3.69e-0343422GO:0140828
GeneOntologyMolecularFunctionsodium channel activity

SCN2A SCN8A

5.36e-0352422GO:0005272
GeneOntologyMolecularFunctionphospholipid transporter activity

XKR4 CETP

1.06e-0274422GO:0005548
GeneOntologyMolecularFunctioncalmodulin binding

SLC8A2 SLC8A1 SCN2A

1.24e-02230423GO:0005516
GeneOntologyBiologicalProcessvesicle cargo loading

CTAGE9 CTAGE15 CTAGE6 MIA2 CTAGE4 CTAGE8

1.41e-1036456GO:0035459
GeneOntologyBiologicalProcessendoplasmic reticulum to Golgi vesicle-mediated transport

CTAGE9 CTAGE15 CTAGE6 MIA2 CTAGE4 GOLT1A CTAGE8

5.03e-08159457GO:0006888
GeneOntologyBiologicalProcesschloride transmembrane transport

LRRC8A CLCN1 CLCN2 CLCN3 CLCN4 CLCN5

1.54e-07112456GO:1902476
GeneOntologyBiologicalProcessinorganic ion transmembrane transport

LRRC8A SLC8A2 SLC8A1 CLCN1 CLCN2 PKD1L2 CLCN3 CLCN4 CLCN5 SCN2A TRPC6 PKD1L1 SCN8A

1.58e-0710174513GO:0098660
GeneOntologyBiologicalProcesschloride transport

LRRC8A CLCN1 CLCN2 CLCN3 CLCN4 CLCN5

3.39e-07128456GO:0006821
GeneOntologyBiologicalProcessinorganic anion transmembrane transport

LRRC8A CLCN1 CLCN2 CLCN3 CLCN4 CLCN5

4.44e-07134456GO:0098661
GeneOntologyBiologicalProcessmonoatomic ion transmembrane transport

LRRC8A SLC8A2 SLC8A1 CLCN1 CLCN2 PKD1L2 CLCN3 CLCN4 CLCN5 SCN2A TRPC6 PKD1L1 SCN8A

4.54e-0711154513GO:0034220
GeneOntologyBiologicalProcessprotein secretion

TVP23C LRRC8A CTAGE9 CTAGE15 CTAGE6 TVP23B MIA2 CTAGE4 CTAGE8

7.82e-07480459GO:0009306
GeneOntologyBiologicalProcessestablishment of protein localization to extracellular region

TVP23C LRRC8A CTAGE9 CTAGE15 CTAGE6 TVP23B MIA2 CTAGE4 CTAGE8

8.23e-07483459GO:0035592
GeneOntologyBiologicalProcessprotein localization to extracellular region

TVP23C LRRC8A CTAGE9 CTAGE15 CTAGE6 TVP23B MIA2 CTAGE4 CTAGE8

9.28e-07490459GO:0071692
GeneOntologyBiologicalProcessmonoatomic anion transmembrane transport

LRRC8A CLCN1 CLCN2 CLCN3 CLCN4 CLCN5

9.69e-07153456GO:0098656
GeneOntologyBiologicalProcessinorganic anion transport

LRRC8A CLCN1 CLCN2 CLCN3 CLCN4 CLCN5

2.50e-06180456GO:0015698
GeneOntologyBiologicalProcessmonoatomic anion transport

LRRC8A CLCN1 CLCN2 CLCN3 CLCN4 CLCN5

2.75e-06183456GO:0006820
GeneOntologyBiologicalProcesstriglyceride homeostasis

CTAGE9 MIA2 CETP CTAGE8

4.23e-0650454GO:0070328
GeneOntologyBiologicalProcessexport from cell

TVP23C LRRC8A CTAGE9 CTAGE15 SLC8A2 SLC8A1 CTAGE6 TVP23B MIA2 CTAGE4 SYNGR3 CTAGE8

4.53e-0611534512GO:0140352
GeneOntologyBiologicalProcessacylglycerol homeostasis

CTAGE9 MIA2 CETP CTAGE8

4.58e-0651454GO:0055090
GeneOntologyBiologicalProcessmonoatomic ion transport

LRRC8A SLC8A2 SLC8A1 CLCN1 CLCN2 PKD1L2 CLCN3 CLCN4 CLCN5 SCN2A TRPC6 PKD1L1 SCN8A

4.70e-0613744513GO:0006811
GeneOntologyBiologicalProcessaction potential

SLC8A2 SLC8A1 CLCN1 SCN2A CNTNAP1 SCN8A

4.72e-06201456GO:0001508
GeneOntologyBiologicalProcessGolgi vesicle transport

CTAGE9 CTAGE15 CTAGE6 MIA2 CTAGE4 GOLT1A CTAGE8

8.08e-06339457GO:0048193
GeneOntologyBiologicalProcessmembrane depolarization during action potential

SLC8A1 SCN2A SCN8A

6.59e-0536453GO:0086010
GeneOntologyBiologicalProcesssecretion by cell

TVP23C LRRC8A CTAGE9 CTAGE15 CTAGE6 TVP23B MIA2 CTAGE4 SYNGR3 CTAGE8

7.82e-0510644510GO:0032940
GeneOntologyBiologicalProcessimport into cell

LRRC8A SLC8A2 SLC8A1 CLCN2 CLCN3 CLCN5 XKR4 MYCBPAP LMBRD1 SYNGR3

8.45e-0510744510GO:0098657
GeneOntologyBiologicalProcesstransmission of nerve impulse

CLCN1 SCN2A CNTNAP1 SCN8A

1.03e-04112454GO:0019226
GeneOntologyBiologicalProcesscholesterol homeostasis

CTAGE9 MIA2 CETP CTAGE8

1.53e-04124454GO:0042632
GeneOntologyBiologicalProcesssterol homeostasis

CTAGE9 MIA2 CETP CTAGE8

1.58e-04125454GO:0055092
GeneOntologyBiologicalProcesssecretion

TVP23C LRRC8A CTAGE9 CTAGE15 CTAGE6 TVP23B MIA2 CTAGE4 SYNGR3 CTAGE8

2.42e-0412214510GO:0046903
GeneOntologyBiologicalProcesschemical homeostasis

LRRC8A CTAGE9 IREB2 SLC8A2 SLC8A1 MIA2 CLCN3 CETP TRPC6 CTAGE8

2.91e-0412494510GO:0048878
GeneOntologyBiologicalProcessneuronal action potential propagation

CLCN1 CNTNAP1

3.03e-0412452GO:0019227
GeneOntologyBiologicalProcessaction potential propagation

CLCN1 CNTNAP1

3.03e-0412452GO:0098870
GeneOntologyBiologicalProcessphagocytosis, engulfment

CLCN2 CLCN3 XKR4

4.60e-0469453GO:0006911
GeneOntologyBiologicalProcessplasma membrane invagination

CLCN2 CLCN3 XKR4

6.58e-0478453GO:0099024
GeneOntologyBiologicalProcessinorganic cation transmembrane transport

SLC8A2 SLC8A1 PKD1L2 CLCN3 SCN2A TRPC6 PKD1L1 SCN8A

7.65e-04922458GO:0098662
GeneOntologyBiologicalProcessmonoatomic cation transmembrane transport

SLC8A2 SLC8A1 PKD1L2 CLCN3 SCN2A TRPC6 PKD1L1 SCN8A

8.79e-04942458GO:0098655
GeneOntologyBiologicalProcesscardiac muscle cell action potential

SLC8A1 SCN2A SCN8A

9.05e-0487453GO:0086001
GeneOntologyBiologicalProcessmembrane invagination

CLCN2 CLCN3 XKR4

9.05e-0487453GO:0010324
GeneOntologyBiologicalProcesssodium ion transmembrane transport

SLC8A2 SLC8A1 SCN2A SCN8A

1.08e-03208454GO:0035725
GeneOntologyBiologicalProcesslipid homeostasis

CTAGE9 MIA2 CETP CTAGE8

1.14e-03211454GO:0055088
GeneOntologyBiologicalProcessregulation of membrane potential

SLC8A2 SLC8A1 CLCN1 SCN2A CNTNAP1 SCN8A

1.28e-03559456GO:0042391
GeneOntologyBiologicalProcesspositive regulation of cytosolic calcium ion concentration

SLC8A2 SLC8A1 FPR3 TRPC6

1.42e-03224454GO:0007204
GeneOntologyBiologicalProcesscalcium ion transmembrane transport

SLC8A2 SLC8A1 PKD1L2 TRPC6 PKD1L1

1.58e-03392455GO:0070588
GeneOntologyBiologicalProcessregulation of cardiac conduction

SLC8A2 SLC8A1

1.82e-0329452GO:1903779
GeneOntologyBiologicalProcessmembrane depolarization

SLC8A1 SCN2A SCN8A

2.33e-03121453GO:0051899
GeneOntologyCellularComponentendoplasmic reticulum exit site

CTAGE9 CTAGE15 CTAGE6 MIA2 CTAGE4 CTAGE8

4.00e-1042466GO:0070971
GeneOntologyCellularComponentmonoatomic ion channel complex

LRRC8A CLCN1 CLCN2 SCN2A TRPC6 PKD1L1 SCN8A

1.74e-05378467GO:0034702
GeneOntologyCellularComponentpresynapse

SLC8A2 SLC8A1 CLCN3 CLCN4 CLCN5 SCN2A SYNGR3 CNTNAP1 SCN8A

1.14e-04886469GO:0098793
GeneOntologyCellularComponenttransmembrane transporter complex

LRRC8A CLCN1 CLCN2 SCN2A TRPC6 PKD1L1 SCN8A

1.35e-04523467GO:1902495
GeneOntologyCellularComponenttransporter complex

LRRC8A CLCN1 CLCN2 SCN2A TRPC6 PKD1L1 SCN8A

1.85e-04550467GO:1990351
GeneOntologyCellularComponentmembrane protein complex

LRRC8A CLCN1 CLCN2 CTDNEP1 MYCBPAP SUN2 TIMM23B SCN2A TRPC6 PKD1L1 SCN8A

3.18e-0414984611GO:0098796
GeneOntologyCellularComponentendoplasmic reticulum membrane

CTAGE9 CTAGE15 CTAGE6 MIA2 CTAGE4 CLCN4 CTDNEP1 SERINC1 LMBRD1 CTAGE8

4.17e-0412934610GO:0005789
GeneOntologyCellularComponentendoplasmic reticulum subcompartment

CTAGE9 CTAGE15 CTAGE6 MIA2 CTAGE4 CLCN4 CTDNEP1 SERINC1 LMBRD1 CTAGE8

4.32e-0412994610GO:0098827
GeneOntologyCellularComponentlysosomal membrane

LRRC8A DEPDC5 CLCN3 CLCN4 CLCN5 LMBRD1

5.00e-04462466GO:0005765
GeneOntologyCellularComponentlytic vacuole membrane

LRRC8A DEPDC5 CLCN3 CLCN4 CLCN5 LMBRD1

5.00e-04462466GO:0098852
GeneOntologyCellularComponentnuclear outer membrane-endoplasmic reticulum membrane network

CTAGE9 CTAGE15 CTAGE6 MIA2 CTAGE4 CLCN4 CTDNEP1 SERINC1 LMBRD1 CTAGE8

5.12e-0413274610GO:0042175
GeneOntologyCellularComponentvoltage-gated sodium channel complex

SCN2A SCN8A

6.31e-0417462GO:0001518
GeneOntologyCellularComponentparanode region of axon

SCN2A CNTNAP1

6.31e-0417462GO:0033270
GeneOntologyCellularComponentsarcolemma

SLC8A2 SLC8A1 CLCN1 SCN2A

8.01e-04190464GO:0042383
GeneOntologyCellularComponentvacuolar membrane

LRRC8A DEPDC5 CLCN3 CLCN4 CLCN5 LMBRD1

8.13e-04507466GO:0005774
GeneOntologyCellularComponentnode of Ranvier

SCN2A SCN8A

8.78e-0420462GO:0033268
GeneOntologyCellularComponentmain axon

SCN2A CNTNAP1 SCN8A

9.92e-0489463GO:0044304
GeneOntologyCellularComponentcation channel complex

SCN2A TRPC6 PKD1L1 SCN8A

1.75e-03235464GO:0034703
GeneOntologyCellularComponentaxon initial segment

SCN2A SCN8A

1.85e-0329462GO:0043194
GeneOntologyCellularComponentsodium channel complex

SCN2A SCN8A

1.85e-0329462GO:0034706
GeneOntologyCellularComponentaxon

IREB2 SLC8A2 SLC8A1 CLCN3 SCN2A CNTNAP1 SCN8A

3.13e-03891467GO:0030424
GeneOntologyCellularComponentsynaptic vesicle

CLCN3 CLCN4 CLCN5 SYNGR3

4.22e-03300464GO:0008021
GeneOntologyCellularComponentexocytic vesicle

CLCN3 CLCN4 CLCN5 SYNGR3

5.30e-03320464GO:0070382
GeneOntologyCellularComponentchloride channel complex

CLCN1 CLCN2

7.00e-0357462GO:0034707
HumanPhenoFocal tonic seizure

CLCN4 SCN2A SCN8A

6.28e-0523183HP:0011167
HumanPhenoEEG with focal spikes

DEPDC5 CLCN4 SCN2A

9.16e-0526183HP:0011193
HumanPhenoSimple febrile seizure

DEPDC5 SCN2A SCN8A

1.03e-0427183HP:0011171
HumanPhenoFocal head nodding automatism seizure

SCN2A SCN8A

1.17e-045182HP:0032906
HumanPhenoNeonatal electro-clinical non-motor seizure

SCN2A SCN8A

1.17e-045182HP:0032812
HumanPhenoNeonatal seizure with electrographic correlate

SCN2A SCN8A

1.17e-045182HP:0032808
HumanPhenoNeonatal electro-clinical seizure

SCN2A SCN8A

1.17e-045182HP:0032809
HumanPhenoNeonatal electro-clinical seizure with behavior arrest

SCN2A SCN8A

1.17e-045182HP:0032823
HumanPhenoNormal interictal EEG

SCN2A SCN8A

1.75e-046182HP:0002372
HumanPhenoBilateral tonic-clonic seizure

IREB2 DEPDC5 CLCN2 CLCN3 CLCN4 SCN2A SCN8A

2.36e-04394187HP:0002069
HumanPhenoEyelid myoclonia seizure

SCN2A SCN8A

2.45e-047182HP:0032678
HumanPhenoDelayed myelination

IREB2 FANCB RMND1 CLCN3 CLCN4 SCN2A

2.77e-04280186HP:0012448
HumanPhenoFocal non-motor seizure

DEPDC5 SCN2A SCN8A

3.37e-0440183HP:0032679
HumanPhenoNon-motor seizure

DEPDC5 CLCN2 CLCN4 SCN2A SCN8A

4.67e-04197185HP:0033259
HumanPhenoThird trimester onset

FANCB DEPDC5 CNTNAP1

4.79e-0445183HP:0034197
HumanPhenoPsychic epileptic aura

DEPDC5 SCN8A

5.22e-0410182HP:0033346
HumanPhenoExperiential epileptic aura

DEPDC5 SCN8A

5.22e-0410182HP:0012002
HumanPhenoFocal autonomic seizure

DEPDC5 SCN8A

6.37e-0411182HP:0011154
HumanPhenoNeonatal seizure

SCN2A SCN8A

6.37e-0411182HP:0032807
HumanPhenoEEG with focal epileptiform discharges

DEPDC5 CLCN4 SCN2A SCN8A

6.51e-04118184HP:0011185
HumanPhenoAbnormal myelination

IREB2 FANCB RMND1 CLCN3 CLCN4 SCN2A CNTNAP1 SCN8A

6.73e-04622188HP:0012447
HumanPhenoBilateral tonic-clonic seizure with focal onset

DEPDC5 SCN2A SCN8A

7.35e-0452183HP:0007334
HumanPhenoBilateral tonic-clonic seizure with generalized onset

IREB2 CLCN2 SCN2A

7.35e-0452183HP:0025190
HumanPhenoFocal automatism seizure

SCN2A SCN8A

7.62e-0412182HP:0032898
HumanPhenoFocal impaired awareness seizure

DEPDC5 CLCN4 SCN2A SCN8A

8.34e-04126184HP:0002384
MousePhenoparesis

LRRC8A CLCN1 CNTNAP1 SCN8A

6.95e-0653334MP:0000754
MousePhenodecreased circulating VLDL triglyceride level

CTAGE9 MIA2 CTAGE8

1.13e-0519333MP:0003976
MousePhenokyphosis

IREB2 CLCN1 CLCN3 CLCN5 TIMM23B CNTNAP1

1.38e-05229336MP:0000160
MousePhenoparaparesis

LRRC8A CLCN1 SCN8A

5.67e-0532333MP:0009434
MousePhenoabnormal spine curvature

IREB2 CLCN1 CLCN3 CLCN5 TIMM23B CNTNAP1

8.72e-05318336MP:0004174
MousePhenohindlimb paresis

LRRC8A CLCN1 SCN8A

8.82e-0537333MP:0031204
MousePhenodecreased circulating HDL cholesterol level

P2RY13 CTAGE9 CLCN1 MIA2 CTAGE8

1.88e-04230335MP:0000186
MousePhenoabnormal posture

IREB2 CLCN1 CLCN3 CNTNAP1 SCN8A

2.43e-04243335MP:0001504
MousePhenoabnormal nerve conduction

CLCN2 CNTNAP1 SCN8A

3.56e-0459333MP:0005403
MousePhenoimpaired limb coordination

CLCN1 CNTNAP1 SCN8A

3.56e-0459333MP:0001524
MousePhenomuscle spasm

CLCN1 CNTNAP1 SCN8A

3.74e-0460333MP:0000743
MousePhenoabnormal muscle relaxation

SLC8A1 CLCN1 SCN8A

3.93e-0461333MP:0004036
MousePhenomuscle twitch

CLCN1 CNTNAP1 SCN8A

4.53e-0464333MP:0009046
DomainCl-channel_core

CLCN1 CLCN2 CLCN3 CLCN4 CLCN5

4.35e-129405IPR014743
Domain-

CLCN1 CLCN2 CLCN3 CLCN4 CLCN5

4.35e-1294051.10.3080.10
DomainVoltage_CLC

CLCN1 CLCN2 CLCN3 CLCN4 CLCN5

4.35e-129405PF00654
DomainCl-channel_volt-gated

CLCN1 CLCN2 CLCN3 CLCN4 CLCN5

4.35e-129405IPR001807
DomainCBS_dom

CLCN1 CLCN2 CLCN3 CLCN4 CLCN5

5.26e-1020405IPR000644
DomainCBS

CLCN1 CLCN2 CLCN3 CLCN4 CLCN5

5.26e-1020405PF00571
DomainCBS

CLCN1 CLCN2 CLCN3 CLCN4 CLCN5

5.26e-1020405PS51371
DomainCBS

CLCN2 CLCN3 CLCN4 CLCN5

3.22e-0816404SM00116
DomainNa_Ca_Ex

SLC8A2 SLC8A1

1.34e-053402IPR004836
DomainNa_Ca_ex_C

SLC8A2 SLC8A1

1.34e-053402PF16494
DomainNa_Ca_Ex_C-exten

SLC8A2 SLC8A1

1.34e-053402IPR032452
DomainREJ

PKD1L2 PKD1L1

2.68e-054402PS51111
DomainDUF846

TVP23C TVP23B

2.68e-054402PF05832
DomainREJ_dom

PKD1L2 PKD1L1

2.68e-054402IPR014010
DomainDUF846_euk

TVP23C TVP23B

2.68e-054402IPR008564
DomainREJ

PKD1L2 PKD1L1

6.67e-056402PF02010
DomainNa_trans_cytopl

SCN2A SCN8A

6.67e-056402PF11933
DomainPKD/REJ-like

PKD1L2 PKD1L1

6.67e-056402IPR002859
DomainNa_trans_cytopl

SCN2A SCN8A

6.67e-056402IPR024583
DomainCalx_beta

SLC8A2 SLC8A1

1.24e-048402SM00237
DomainCalx_beta

SLC8A2 SLC8A1

1.59e-049402IPR003644
DomainNaCa_Exmemb

SLC8A2 SLC8A1

1.59e-049402IPR004837
DomainNa_Ca_ex

SLC8A2 SLC8A1

1.59e-049402PF01699
DomainCalx-beta

SLC8A2 SLC8A1

1.59e-049402PF03160
DomainNa_channel_asu

SCN2A SCN8A

1.99e-0410402IPR001696
DomainNa_trans_assoc

SCN2A SCN8A

1.99e-0410402IPR010526
DomainNa_trans_assoc

SCN2A SCN8A

1.99e-0410402PF06512
DomainPKD1_2_channel

PKD1L2 PKD1L1

2.43e-0411402IPR013122
DomainPKD_channel

PKD1L2 PKD1L1

2.43e-0411402PF08016
DomainEamA_dom

SLC35F3 SLC35F5

4.00e-0414402IPR000620
DomainEamA

SLC35F3 SLC35F5

4.00e-0414402PF00892
DomainLH2

PKD1L2 PKD1L1

6.70e-0418402SM00308
DomainPLAT

PKD1L2 PKD1L1

9.15e-0421402PF01477
DomainPLAT

PKD1L2 PKD1L1

9.15e-0421402PS50095
DomainPLAT/LH2_dom

PKD1L2 PKD1L1

9.15e-0421402IPR001024
Domain-

PKD1L2 PKD1L1

9.15e-04214022.60.60.20
DomainIon_trans_dom

SCN2A TRPC6 SCN8A

1.86e-03114403IPR005821
DomainIon_trans

SCN2A TRPC6 SCN8A

1.86e-03114403PF00520
DomainGPS

PKD1L2 PKD1L1

2.69e-0336402PS50221
DomainGPS

PKD1L2 PKD1L1

2.84e-0337402IPR000203
DomainChannel_four-helix_dom

SCN2A SCN8A

6.63e-0357402IPR027359
Domain-

SCN2A SCN8A

6.63e-03574021.20.120.350
PathwayREACTOME_STIMULI_SENSING_CHANNELS

CLCN1 CLCN2 CLCN3 CLCN4 CLCN5 TRPC6

5.16e-08106286M27200
PathwayREACTOME_TRANSPORT_OF_SMALL_MOLECULES

LRRC8A IREB2 SLC8A2 SLC8A1 CLCN1 CLCN2 CLCN3 CLCN4 CLCN5 CETP TRPC6

6.92e-087362811M27287
PathwayREACTOME_ION_CHANNEL_TRANSPORT

CLCN1 CLCN2 CLCN3 CLCN4 CLCN5 TRPC6

1.31e-06183286M997
PathwayREACTOME_STIMULI_SENSING_CHANNELS

CLCN1 CLCN2 CLCN4 CLCN5 TRPC6

1.33e-0699285MM14910
PathwayREACTOME_TRANSPORT_OF_SMALL_MOLECULES

LRRC8A IREB2 SLC8A2 SLC8A1 CLCN1 CLCN2 CLCN4 CLCN5 TRPC6

4.10e-06681289MM14985
PathwayREACTOME_PLATELET_CALCIUM_HOMEOSTASIS

SLC8A2 SLC8A1 TRPC6

1.99e-0527283MM15053
PathwayREACTOME_PLATELET_CALCIUM_HOMEOSTASIS

SLC8A2 SLC8A1 TRPC6

2.22e-0528283M924
PathwayREACTOME_ION_CHANNEL_TRANSPORT

CLCN1 CLCN2 CLCN4 CLCN5 TRPC6

2.23e-05176285MM15718
PathwayREACTOME_CARGO_CONCENTRATION_IN_THE_ER

CTAGE9 MIA2 CTAGE8

4.80e-0536283MM15300
PathwayREACTOME_CARDIAC_CONDUCTION

SLC8A2 SLC8A1 SCN2A SCN8A

1.19e-04130284M27454
PathwayREACTOME_SODIUM_CALCIUM_EXCHANGERS

SLC8A2 SLC8A1

2.07e-0411282M27336
PathwayREACTOME_REDUCTION_OF_CYTOSOLIC_CA_LEVELS

SLC8A2 SLC8A1

2.48e-0412282M27326
PathwayREACTOME_SODIUM_CALCIUM_EXCHANGERS

SLC8A2 SLC8A1

2.93e-0413282MM15078
PathwayREACTOME_REDUCTION_OF_CYTOSOLIC_CA_LEVELS

SLC8A2 SLC8A1

3.41e-0414282MM15052
PathwayREACTOME_PLATELET_HOMEOSTASIS

SLC8A2 SLC8A1 TRPC6

4.48e-0476283MM15051
PathwayREACTOME_PLATELET_HOMEOSTASIS

SLC8A2 SLC8A1 TRPC6

6.43e-0486283M916
PathwayREACTOME_MUSCLE_CONTRACTION

SLC8A2 SLC8A1 SCN2A SCN8A

6.52e-04203284M5485
PathwayWP_FATTY_ACIDS_AND_LIPOPROTEINS_TRANSPORT_IN_HEPATOCYTES

MIA2 CLCN5 SERINC1 LMBRD1 CETP

8.27e-04381285M48063
PathwayWP_DRAVET_SYNDROME

SCN2A SCN8A

1.39e-0328282M45519
PathwayREACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS

SCN2A SCN8A

1.71e-0331282M877
PathwayREACTOME_L1CAM_INTERACTIONS

SCN2A CNTNAP1 SCN8A

1.73e-03121283M872
PathwayREACTOME_PHASE_0_RAPID_DEPOLARISATION

SCN2A SCN8A

1.82e-0332282M27455
PathwayWP_RETT_SYNDROME

SCN2A SCN8A

4.06e-0348282M39759
PathwayREACTOME_ER_TO_GOLGI_ANTEROGRADE_TRANSPORT

CTAGE9 MIA2 CTAGE8

4.38e-03168283MM14785
PathwayREACTOME_ION_HOMEOSTASIS

SLC8A2 SLC8A1

5.11e-0354282MM15202
PathwayREACTOME_ION_HOMEOSTASIS

SLC8A2 SLC8A1

5.11e-0354282M27460
PathwayWP_ADHD_AND_AUTISM_ASD_PATHWAYS

LMBRD1 SCN2A CNTNAP1 SCN8A

5.64e-03367284M48346
Pubmed

Expression of CLCN voltage-gated chloride channel genes in human blood vessels.

CLCN1 CLCN2 CLCN3 CLCN4 CLCN5

1.94e-14646510198195
Pubmed

Changing expression of chloride channels during preimplantation mouse development.

CLCN1 CLCN2 CLCN3 CLCN4 CLCN5

4.06e-13946523115349
Pubmed

Large-scale analysis of ion channel gene expression in the mouse heart during perinatal development.

SLC8A1 CLCN1 CLCN2 CLCN3 CLCN4 CLCN5 SCN8A

6.57e-1013946716985003
Pubmed

Role of ClC-5 in renal endocytosis is unique among ClC exchangers and does not require PY-motif-dependent ubiquitylation.

CLCN3 CLCN4 CLCN5

8.65e-09446320351103
Pubmed

Deletion of Mea6 in Cerebellar Granule Cells Impairs Synaptic Development and Motor Performance.

CTAGE9 MIA2 CTAGE8

8.65e-09446333718348
Pubmed

Specific expression and regulation of the new melanoma inhibitory activity-related gene MIA2 in hepatocytes.

CTAGE9 MIA2 CTAGE8

8.65e-09446312586826
Pubmed

Mea6 controls VLDL transport through the coordinated regulation of COPII assembly.

CTAGE9 MIA2 CTAGE8

8.65e-09446327311593
Pubmed

MEA6 Deficiency Impairs Cerebellar Development and Motor Performance by Tethering Protein Trafficking.

CTAGE9 MIA2 CTAGE8

8.65e-09446331244610
Pubmed

Reduced cholesterol and triglycerides in mice with a mutation in Mia2, a liver protein that localizes to ER exit sites.

CTAGE9 MIA2 CTAGE8

8.65e-09446321807889
Pubmed

Specific phosphopeptide enrichment with immobilized titanium ion affinity chromatography adsorbent for phosphoproteome analysis.

CTAGE9 MIA2 CTAGE8

2.16e-08546318630941
Pubmed

cTAGE: a cutaneous T cell lymphoma associated antigen family with tumor-specific splicing.

CTAGE9 MIA2 CTAGE4

2.16e-08546312839582
Pubmed

Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry.

CTAGE9 MIA2 CTAGE8

2.16e-08546319131326
Pubmed

Characterization and expression pattern of the novel MIA homolog TANGO.

CTAGE9 MIA2 CTAGE8

2.16e-08546315183315
Pubmed

Mea6/cTAGE5 cooperates with TRAPPC12 to regulate PTN secretion and white matter development.

CTAGE9 MIA2 CTAGE8

2.16e-08546338439956
Pubmed

A tissue-specific atlas of mouse protein phosphorylation and expression.

CTAGE9 MIA2 CTAGE8

2.16e-08546321183079
Pubmed

An essential role for ClC-4 in transferrin receptor function revealed in studies of fibroblasts derived from Clcn4-null mice.

CLCN3 CLCN4 CLCN5

2.16e-08546319339555
Pubmed

cTAGE5 deletion in pancreatic β cells impairs proinsulin trafficking and insulin biogenesis in mice.

CTAGE9 MIA2 CTAGE8

7.55e-08746329133483
Pubmed

Ion channel expression in the developing enteric nervous system.

CLCN2 CLCN3 CLCN4 CLCN5

1.71e-073746425798587
Pubmed

Misexpression of MIA disrupts lung morphogenesis and causes neonatal death.

CTAGE9 MIA2 CTAGE8

1.81e-07946318342301
Pubmed

Ultrastructural cartilage abnormalities in MIA/CD-RAP-deficient mice.

CTAGE9 MIA2 CTAGE8

6.14e-071346311839810
Pubmed

WAVE1 is required for oligodendrocyte morphogenesis and normal CNS myelination.

SCN2A CNTNAP1 SCN8A

6.14e-071346316723544
Pubmed

cTAGE5/MEA6 plays a critical role in neuronal cellular components trafficking and brain development.

CTAGE9 MIA2 CTAGE8

9.74e-071546330224460
Pubmed

Polycystin-1L2 is a novel G-protein-binding protein.

PKD1L2 PKD1L1

1.71e-06246215203210
Pubmed

Uncoupling endosomal CLC chloride/proton exchange causes severe neurodegeneration.

CLCN3 CLCN4

1.71e-06246232118314
Pubmed

Sodium channel expression within chronic multiple sclerosis plaques.

SCN2A SCN8A

1.71e-06246217805013
Pubmed

Roles of Na(+)/Ca(2+) exchanger isoforms NCX1 and NCX2 in motility in mouse ileum.

SLC8A2 SLC8A1

1.71e-06246227411318
Pubmed

Na+/Ca2+ exchanger contributes to stool transport in mice with experimental diarrhea.

SLC8A2 SLC8A1

1.71e-06246227928109
Pubmed

Na(+) /Ca(2+) exchanger-heterozygote knockout mice display increased relaxation in gastric fundus and accelerated gastric transit in vivo.

SLC8A2 SLC8A1

1.71e-06246226787195
Pubmed

Commonalities and distinctions between two neurodevelopmental disorder subtypes associated with SCN2A and SCN8A variants and literature review.

SCN2A SCN8A

1.71e-06246235348308
Pubmed

Electrophysiological properties of two axonal sodium channels, Nav1.2 and Nav1.6, expressed in mouse spinal sensory neurones.

SCN2A SCN8A

1.71e-06246215760941
Pubmed

Identification and functional characterization of a voltage-gated chloride channel and its novel splice variant in taste bud cells.

CLCN4 CLCN5

1.71e-06246216129671
Pubmed

Genetic knockout and pharmacologic inhibition of NCX2 cause natriuresis and hypercalciuria.

SLC8A2 SLC8A1

1.71e-06246225498502
Pubmed

Reduced expression of Na(v)1.6 sodium channels and compensation by Na(v)1.2 channels in mice heterozygous for a null mutation in Scn8a.

SCN2A SCN8A

1.71e-06246218601978
Pubmed

Expression of voltage-gated chloride channels in human glioma cells.

CLCN2 CLCN3

1.71e-06246212843258
Pubmed

Preferential association with ClC-3 permits sorting of ClC-4 into endosomal compartments.

CLCN3 CLCN4

1.71e-06246228972156
Pubmed

FGF14 N-terminal splice variants differentially modulate Nav1.2 and Nav1.6-encoded sodium channels.

SCN2A SCN8A

1.71e-06246219465131
Pubmed

Chloride/proton antiporters ClC3 and ClC5 support bone formation in mice.

CLCN3 CLCN5

1.71e-06246238666049
Pubmed

Chloride/proton antiporter activity of mammalian CLC proteins ClC-4 and ClC-5.

CLCN4 CLCN5

1.71e-06246216034421
Pubmed

Block of a subset of sodium channels exacerbates experimental autoimmune encephalomyelitis.

SCN2A SCN8A

1.71e-06246223735284
Pubmed

Kv7/KCNQ potassium channels in cortical hyperexcitability and juvenile seizure-related death in Ank2-mutant mice.

SCN2A CNTNAP1 SCN8A

1.74e-061846337321992
Pubmed

Evidence of evolutionary up-regulation of the single active X chromosome in mammals based on Clc4 expression levels in Mus spretus and Mus musculus.

CLCN4 CLCN5

5.13e-0634629256467
Pubmed

Structure-Dynamic Coupling Through Ca2+-Binding Regulatory Domains of Mammalian NCX Isoform/Splice Variants.

SLC8A2 SLC8A1

5.13e-06346229594857
Pubmed

Ontogeny of CLCN3 chloride channel gene expression in human pulmonary epithelium.

CLCN2 CLCN3

5.13e-06346211306429
Pubmed

Aberrant Amygdala-Dependent Cued Fear Memory in Na+/Ca2+ Exchanger 1 Heterozygous Mice.

SLC8A2 SLC8A1

5.13e-06346230324228
Pubmed

The downregulation of NCXs is positively correlated with the prognosis of stage II-IV colon cancer.

SLC8A2 SLC8A1

5.13e-06346234127021
Pubmed

Sodium-calcium exchange in intracellular calcium handling of human airway smooth muscle.

SLC8A2 SLC8A1

5.13e-06346221858195
Pubmed

Reduced sodium current in Purkinje neurons from Nav1.1 mutant mice: implications for ataxia in severe myoclonic epilepsy in infancy.

SCN2A SCN8A

5.13e-06346217928448
Pubmed

Immunosuppressive drugs, immunophilins, and functional expression of NCX isoforms.

SLC8A2 SLC8A1

5.13e-06346223224887
Pubmed

New roles of NCX in glial cells: activation of microglia in ischemia and differentiation of oligodendrocytes.

SLC8A2 SLC8A1

5.13e-06346223224890
Pubmed

Genetically modified mice as a strategy to unravel the role played by the Na(+)/Ca (2+) exchanger in brain ischemia and in spatial learning and memory deficits.

SLC8A2 SLC8A1

5.13e-06346223224882
Pubmed

High levels of synaptosomal Na(+)-Ca(2+) exchangers (NCX1, NCX2, NCX3) co-localized with amyloid-beta in human cerebral cortex affected by Alzheimer's disease.

SLC8A2 SLC8A1

5.13e-06346221382638
Pubmed

Experimental and computational evidence that Calpain-10 binds to the carboxy terminus of NaV1.2 and NaV1.6.

SCN2A SCN8A

5.13e-06346238514708
Pubmed

Three Na+/Ca2+ exchanger (NCX) variants are expressed in mouse osteoclasts and mediate calcium transport during bone resorption.

SLC8A2 SLC8A1

5.13e-06346217317768
Pubmed

Support of bone mineral deposition by regulation of pH.

CLCN3 CLCN5

5.13e-06346230044661
Pubmed

Variable patterns of mutation density among NaV1.1, NaV1.2 and NaV1.6 point to channel-specific functional differences associated with childhood epilepsy.

SCN2A SCN8A

5.13e-06346232845893
Pubmed

Where is the spike generator of the cochlear nerve? Voltage-gated sodium channels in the mouse cochlea.

SCN2A SCN8A

5.13e-06346216033895
Pubmed

Role of sodium channel subtype in action potential generation by neocortical pyramidal neurons.

SCN2A SCN8A

5.13e-06346229991598
Pubmed

De novo SCN1A, SCN8A, and CLCN2 mutations in childhood absence epilepsy.

CLCN2 SCN8A

5.13e-06346231054517
Pubmed

Direct recording and molecular identification of the calcium channel of primary cilia.

PKD1L2 PKD1L1

5.13e-06346224336289
Pubmed

Comparison and optimization of in silico algorithms for predicting the pathogenicity of sodium channel variants in epilepsy.

SCN2A SCN8A

5.13e-06346228518218
Pubmed

Na+/Ca2+ exchanger isoform 1 (NCX1) and canonical transient receptor potential channel 6 (TRPC6) are recruited by STIM1 to mediate Store-Operated Calcium Entry in primary cortical neurons.

SLC8A1 TRPC6

5.13e-06346234995919
Pubmed

Possible role of transforming growth factor beta and interleukin-4 in the up-regulation of CLC-2 and CLC-3 in chronic rhinosinusitis.

CLCN2 CLCN3

1.03e-05446217882904
Pubmed

Nav1.1 localizes to axons of parvalbumin-positive inhibitory interneurons: a circuit basis for epileptic seizures in mice carrying an Scn1a gene mutation.

SCN2A SCN8A

1.03e-05446217537961
Pubmed

Sodium channel expression and transcript variation in the developing brain of human, Rhesus monkey, and mouse.

SCN2A SCN8A

1.03e-05446235031483
Pubmed

Calcineurin inhibits Na+/Ca2+ exchange in phenylephrine-treated hypertrophic cardiomyocytes.

SLC8A2 SLC8A1

1.03e-05446215557343
Pubmed

A contravention of Ohno's law in mice.

CLCN4 CLCN5

1.03e-0544627670497
Pubmed

Different chromosomal localization of the Clcn4 gene in Mus spretus and C57BL/6J mice.

CLCN4 CLCN5

1.03e-0544627670496
Pubmed

Mutational analysis of CLC-5, cofilin and CLC-4 in patients with Dent's disease.

CLCN4 CLCN5

1.03e-05446219546591
Pubmed

Abnormal changes in voltage-gated sodium channels subtypes NaV1.1, NaV1.2, NaV1.3, NaV1.6 and CaM/CaMKII pathway in low-grade astrocytoma.

SCN2A SCN8A

1.03e-05446229578003
Pubmed

Importance of K+-dependent Na+/Ca2+-exchanger 2, NCKX2, in motor learning and memory.

SLC8A2 SLC8A1

1.03e-05446216407245
Pubmed

Reduced expression of Na+/Ca2+ exchangers is associated with cognitive deficits seen in Alzheimer's disease model mice.

SLC8A2 SLC8A1

1.03e-05446229274751
Pubmed

Neuronal voltage-gated ion channels are genetic modifiers of generalized epilepsy with febrile seizures plus.

SCN2A SCN8A

1.03e-05446221156207
Pubmed

Chloride and the endosomal-lysosomal pathway: emerging roles of CLC chloride transporters.

CLCN3 CLCN5

1.03e-05446217110406
Pubmed

Calcium-binding protein, parvalbumin, is reduced in mutant mammalian muscle with abnormal contractile properties.

CLCN1 SCN8A

1.03e-0544626589628
Pubmed

Hypoxia up-regulates glyceraldehyde-3-phosphate dehydrogenase in mouse brain capillary endothelial cells: involvement of Na+/Ca2+ exchanger.

SLC8A2 SLC8A1

1.03e-05446212581871
Pubmed

A quantitative analysis of the spatiotemporal pattern of transient receptor potential gene expression in the developing mouse cochlea.

PKD1L2 TRPC6 PKD1L1

1.15e-053346319834762
Pubmed

STRAP regulates alternative splicing fidelity during lineage commitment of mouse embryonic stem cells.

CTAGE9 MIA2 CTAGE8

1.50e-053646333230114
Pubmed

Interaction between the transcriptional corepressor Sin3B and voltage-gated sodium channels modulates functional channel expression.

SCN2A SCN8A

1.71e-05546224077057
Pubmed

Structure/function characterization of micro-conotoxin KIIIA, an analgesic, nearly irreversible blocker of mammalian neuronal sodium channels.

SCN2A SCN8A

1.71e-05546217724025
Pubmed

Maternal Transient Receptor Potential Vanilloid 6 (Trpv6) Is Involved In Offspring Bone Development.

SLC8A2 SLC8A1 TRPC6

1.77e-053846330786075
Pubmed

The phagosomal proteome in interferon-gamma-activated macrophages.

CTAGE9 MIA2 CTAGE8

2.07e-054046319144319
Pubmed

Are voltage-dependent ion channels involved in the endothelial cell control of vasomotor tone?

SCN2A SCN8A

2.56e-05646217513486
Pubmed

Sodium/calcium exchanger expression in the mouse and rat olfactory systems.

SLC8A2 SLC8A1

2.56e-05646217311327
Pubmed

A 'toothache tree' alkylamide inhibits Aδ mechanonociceptors to alleviate mechanical pain.

SCN2A SCN8A

2.56e-05646223652591
Pubmed

Developmental waves of mechanosensitivity acquisition in sensory neuron subtypes during embryonic development.

PKD1L2 TRPC6 PKD1L1

2.76e-054446319322198
Pubmed

Inhibitory interaction of the plasma membrane Na+/Ca2+ exchangers with the 14-3-3 proteins.

SLC8A2 SLC8A1

3.58e-05746216679322
Pubmed

Na+/Ca2+ exchanger-deficient mice have disorganized myofibrils and swollen mitochondria in cardiomyocytes.

SLC8A2 SLC8A1

3.58e-05746212781968
Pubmed

Diagnostic yield of genetic testing in epileptic encephalopathy in childhood.

SCN2A SCN8A

3.58e-05746225818041
Pubmed

Regulation of CLC-1 chloride channel biosynthesis by FKBP8 and Hsp90β.

CLCN1 CLCN2

4.77e-05846227580824
Pubmed

Expression pattern of neuronal and skeletal muscle voltage-gated Na+ channels in the developing mouse heart.

SCN2A SCN8A

6.12e-05946215746173
Pubmed

International Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channels.

SCN2A SCN8A

6.12e-05946216382098
Pubmed

Two members of the TRPP family of ion channels, Pkd1l3 and Pkd2l1, are co-expressed in a subset of taste receptor cells.

PKD1L2 PKD1L1

7.65e-051046216805797
Pubmed

Impaired macroglial development and axonal conductivity contributes to the neuropathology of DYRK1A-related intellectual disability syndrome.

CNTNAP1 SCN8A

1.12e-041246236402907
Pubmed

Nav1.2 haplodeficiency in excitatory neurons causes absence-like seizures in mice.

SCN2A SCN8A

1.12e-041246230175250
Pubmed

Regulation of neuronal voltage-gated sodium channels by the ubiquitin-protein ligases Nedd4 and Nedd4-2.

SCN2A SCN8A

1.32e-041346215123669
Pubmed

CNS myelin paranodes require Nkx6-2 homeoprotein transcriptional activity for normal structure.

CNTNAP1 SCN8A

1.32e-041346215601927
Pubmed

Congenital hypomyelinating neuropathy with lethal conduction failure in mice carrying the Egr2 I268N mutation.

CNTNAP1 SCN8A

1.54e-041446219244508
Pubmed

A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome.

CTAGE9 MIA2 TIMM23B CTAGE8

1.58e-0420546412040188
Pubmed

Cloning of a third mammalian Na+-Ca2+ exchanger, NCX3.

SLC8A2 SLC8A1

2.03e-04164628798769
Pubmed

Serological detection of cutaneous T-cell lymphoma-associated antigens.

MIA2 CTAGE4

2.58e-041846211149944
InteractionCTAGE1 interactions

CTAGE15 CTAGE6 MIA2 CTAGE4 CTAGE8

7.68e-1210425int:CTAGE1
InteractionMIA2 interactions

CTAGE15 CTAGE6 MIA2 CTAGE4 CTAGE8

3.66e-06113425int:MIA2
InteractionCTAGE4 interactions

MIA2 CTAGE4

1.27e-053422int:CTAGE4
InteractionCTAGE15 interactions

CTAGE15 MIA2

4.22e-055422int:CTAGE15
InteractionCTAGE7P interactions

CTAGE6 MIA2

6.33e-056422int:CTAGE7P
InteractionCTAGE6 interactions

CTAGE6 MIA2

6.33e-056422int:CTAGE6
InteractionCTAGE8 interactions

MIA2 CTAGE8

6.33e-056422int:CTAGE8
InteractionLGALS9B interactions

LRRC8A CLCN3 CLCN5

1.12e-0445423int:LGALS9B
InteractionSCN4B interactions

SCN2A SCN8A

1.18e-048422int:SCN4B
InteractionHTR2C interactions

TVP23C LRRC8A RMND1 SERINC1

1.53e-04130424int:HTR2C
InteractionC5AR1 interactions

TVP23C RMND1 SERINC1 SLC35F5

2.93e-04154424int:C5AR1
InteractionOR10H2 interactions

LRRC8A CLCN3 CTDNEP1

4.54e-0472423int:OR10H2
Cytoband7q35

CTAGE15 CTAGE6 CLCN1 CTAGE4 CTAGE8

2.70e-09554657q35
CytobandEnsembl 112 genes in cytogenetic band chr7q35

CTAGE15 CTAGE6 CTAGE4 CTAGE8

6.07e-0766464chr7q35
GeneFamilyCTAGE family

CTAGE9 CTAGE15 CTAGE6 MIA2 CTAGE4 CTAGE8

4.86e-1415296907
GeneFamilyChloride voltage-gated channels

CLCN1 CLCN2 CLCN3 CLCN4 CLCN5

1.85e-1210295302
GeneFamilySodium voltage-gated channel alpha subunits

SCN2A SCN8A

8.88e-0592921203
GeneFamilySolute carriers

SLC8A2 SLC8A1 SLC35F3 SLC16A14 SLC35F5

3.74e-04395295752
CoexpressionMANNO_MIDBRAIN_NEUROTYPES_HDA1

SLC8A2 SLC8A1 CLCN4 XKR4 SERINC1 SLC16A14 SCN2A SYNGR3 SCN8A

5.52e-07584459M39068
CoexpressionFOURATI_BLOOD_TWINRIX_AGE_25_83YO_RESPONDERS_VS_POOR_RESPONDERS_0DY_UP

CTAGE9 CTAGE15 FANCB CTAGE6 CTAGE4 CLCN5 SMIM10 CNTNAP1

6.27e-06587458M40869
CoexpressionMANNO_MIDBRAIN_NEUROTYPES_HGABA

TVP23C SLC8A2 SLC8A1 CLCN4 XKR4 SERINC1 SLC16A14 SCN2A SYNGR3 SCN8A

1.42e-0511064510M39071
CoexpressionGSE21927_SPLEEN_VS_TUMOR_MONOCYTE_C57BL6_UP

PKD1L2 CLCN3 MYCBPAP TIMM23B PKD1L1

1.93e-05192455M7582
CoexpressionTERAO_AOX4_TARGETS_HG_UP

CTAGE9 MIA2 CTAGE8

2.27e-0532453MM922
CoexpressionBRACHAT_RESPONSE_TO_METHOTREXATE_DN

CTAGE9 MIA2 CTAGE8

3.82e-0538453MM1161
CoexpressionYANG_BCL3_TARGETS_DN

SUN2 CNTNAP1

8.02e-058452M2425
CoexpressionMATSUMIYA_PBMC_MODIFIED_VACCINIA_ANKARA_VACCINE_AGE_18_55YO_HIGH_RESPONDERS_VS_LOW_RESPONDERS_0DY_UP

ZMYND15 FPR3

1.03e-049452M40953
CoexpressionBRACHAT_RESPONSE_TO_CAMPTOTHECIN_DN

CTAGE9 MIA2 CTAGE8

1.10e-0454453MM1195
CoexpressionMANNO_MIDBRAIN_NEUROTYPES_HSERT

SLC8A2 CLCN4 SLC35F3 SERINC1 SCN2A SYNGR3

1.14e-04450456M39072
CoexpressionMANNO_MIDBRAIN_NEUROTYPES_HDA

SLC8A2 CLCN4 XKR4 SERINC1 SLC16A14 SCN2A

2.16e-04506456M39067
ToppCell(51)_cDC1|World / shred on Cell_type and subtype

ZMYND15 P2RY13 CTAGE9 SLC8A1 CLCN1 CLCN4

5.67e-08204456a8cf4180c406674b7541917d1fc6127686ba5f8a
ToppCellTransverse-(5)_Dendritic_cell-(51)_cDC1|Transverse / shred on region, Cell_type, and subtype

P2RY13 CTAGE9 SLC8A1 CLCN1 CLCN4

1.70e-0619945552dd1c4cd372f8ee515307a9200e357bb2145888
ToppCellCaecum-Dendritic_cell-cDC2|Caecum / Region, Cell class and subclass

ZMYND15 P2RY13 SLC8A1 FPR3 TRPC6

1.70e-06199455944c567307082dd54dc141e93965d46f4ec8bc1f
ToppCellSigmoid-(5)_Dendritic_cell-(50)_cDC2|Sigmoid / shred on region, Cell_type, and subtype

ZMYND15 P2RY13 SLC8A1 CETP TRPC6

1.70e-06199455402af84db90d8a49d67cf44c24766aefb00fd716
ToppCellSigmoid-Dendritic_cell-cDC2|Sigmoid / Region, Cell class and subclass

ZMYND15 P2RY13 SLC8A1 CETP TRPC6

1.70e-06199455cd74db6db694b68f81dcf9d9342d125d00357ec1
ToppCellTransverse-Dendritic_cell-cDC1|Transverse / Region, Cell class and subclass

P2RY13 CTAGE9 SLC8A1 CLCN1 CLCN4

1.70e-06199455b68419939d206417158a703f60a374bf8ec5d5a1
ToppCellCaecum-(5)_Dendritic_cell-(50)_cDC2|Caecum / shred on region, Cell_type, and subtype

ZMYND15 P2RY13 SLC8A1 FPR3 TRPC6

1.70e-06199455bf8a10a9db7e8e0a6e2b53747949f442fe0e581e
ToppCellCaecum-Dendritic_cell|Caecum / Region, Cell class and subclass

ZMYND15 P2RY13 SLC8A1 FPR3 TRPC6

1.75e-06200455b91d3d7505a022ca360ab5b3f9955753d111f974
ToppCellTransverse-(5)_Dendritic_cell-(50)_cDC2|Transverse / shred on region, Cell_type, and subtype

P2RY13 SLC8A1 CETP FPR3 TRPC6

1.75e-06200455eea523f7512b54d7443651bce3ff6d043a9897aa
ToppCellCaecum-(5)_Dendritic_cell|Caecum / shred on region, Cell_type, and subtype

ZMYND15 P2RY13 SLC8A1 FPR3 TRPC6

1.75e-06200455aa87810706fd4164085d8e973359b68a2691842e
ToppCellTransverse-Dendritic_cell-cDC2|Transverse / Region, Cell class and subclass

P2RY13 SLC8A1 CETP FPR3 TRPC6

1.75e-0620045580730a6372627543b84d8fb1b94c481db17c6500
ToppCell(50)_cDC2|World / shred on Cell_type and subtype

ZMYND15 P2RY13 SLC8A1 FPR3 TRPC6

2.02e-06206455d519adeb8290fcce107e81a439ba3bf1e231b55b
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Principal_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

SLC8A1 NLRP9 GOLT1A SCN2A

1.76e-05154454cd99428c282d566b5dbd31fd5a0371b7ffe9ffa2
ToppCell10x_3'_v3-thymus_(10x_3'_v3)-myeloid-myeloid_dendritic|thymus_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

ZMYND15 P2RY13 SLC8A1 CLCN1

2.37e-05166454479391aa6c09aa070b716128ab51b8fec0aea22d
ToppCell5'-Adult-SmallIntestine-Hematopoietic-Myeloid-cDC1|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

P2RY13 SLC8A1 CLCN4 SLC35F3

2.54e-05169454da3485d77bb7876fad4f166f6099e681b27457ae
ToppCell5'-Adult-LargeIntestine-Hematopoietic-Myeloid-cDC1|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ZMYND15 P2RY13 SLC8A1 CLCN4

2.78e-05173454d13ae4046a25ee0fb492ddedf44583a879a432e9
ToppCellmetastatic_Lymph_Node-Myeloid_cells-CD207+CD1a+_LCs|metastatic_Lymph_Node / Location, Cell class and cell subclass

P2RY13 SLC8A1 XKR4 TRPC6

3.25e-05180454289f8c4b53ffd164fee1f459a9315c0deb5f76d0
ToppCell10x5'-lymph-node_spleen-Myeloid_Mac-Intestinal_macrophages|lymph-node_spleen / Manually curated celltypes from each tissue

P2RY13 CTAGE9 SLC8A1 FPR3

3.25e-051804547be7d7a6906fff6dbdecd9cb013d855aba4eda2a
ToppCell10x5'-GI_large-bowel-Myeloid_Dendritic|GI_large-bowel / Manually curated celltypes from each tissue

ZMYND15 P2RY13 SLC8A1 FPR3

3.25e-05180454400f48aa2851d89bf3b60d721bc0f635f3ad86eb
ToppCell10x5'-GI_large-bowel-Myeloid_Dendritic-DC2|GI_large-bowel / Manually curated celltypes from each tissue

ZMYND15 P2RY13 SLC8A1 FPR3

3.25e-05180454d4ebe67a2735e244c08b238320bbb441ca88ee6f
ToppCell3'_v3-GI_small-bowel-Myeloid_Dendritic-DC2|GI_small-bowel / Manually curated celltypes from each tissue

P2RY13 SLC8A1 FPR3 TRPC6

3.46e-05183454c94ee9f35b21252e1ab5ab15b6a2ce69a7d753f7
ToppCell3'_v3-GI_small-bowel-Myeloid_Dendritic|GI_small-bowel / Manually curated celltypes from each tissue

P2RY13 SLC8A1 CLCN1 CLCN4

3.46e-051834546109199cf25b28831193a5ed7925b5bf38c6eb43
ToppCell3'-Child04-06-SmallIntestine-Hematopoietic-Myeloid-Macrophages|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ZMYND15 P2RY13 SLC8A1 FPR3

3.46e-0518345492d5a61b57851090eba558f19e2a7010043eff81
ToppCellNasal_Brush-Immune-Dendritic_cells|Nasal_Brush / Tissue, Lineage and Cell class of Lung Cells from 10X

P2RY13 SLC8A1 CETP FPR3

3.46e-05183454b1daec831990a53e846c089cebfcf4f8440820e4
ToppCell10x_3'_v3-lymph_node_(10x_3'_v3)-myeloid-myeloid_dendritic-CD141-positive_myeloid_dendritic_cell|lymph_node_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

ZMYND15 P2RY13 SLC8A1 CLCN1

3.85e-0518845478e79b8e298aa77c8c01320bab4fb1a00f11a772
ToppCell5'-Adult-Distal_Rectal-Hematopoietic-Myeloid-LYVE1+_Macrophage|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

P2RY13 SLC8A1 FPR3 SCN8A

3.93e-051894549e3c083174a64ea78648c6d48498fc4e721b569f
ToppCell5'-Adult-Distal_Rectal-Hematopoietic-Myeloid|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

P2RY13 SLC8A1 FPR3 SCN8A

3.93e-051894546e19bfa52406ebe095daa99f958ec4d596ce6e39
ToppCell15-Trachea-Epithelial-Neuroendocrine|Trachea / Age, Tissue, Lineage and Cell class

SLC8A2 MIA2 SLC35F3 SCN2A

4.09e-0519145476311fa5f3ae9bb27cf04387a8c92300f2888c28
ToppCell(11)_FOXN4+-(0)_Reference|(11)_FOXN4+ / shred by cell type by condition

CTAGE15 CTAGE6 CLCN2 PKD1L1

4.18e-05192454ef06f96b934dd05b40025f8215b6d919d3a17045
ToppCellHippocampus-Neuronal|Hippocampus / BrainAtlas - Mouse McCarroll V32

XKR4 SCN2A SYNGR3 SCN8A

4.35e-051944548aeb347b3024354c9505f4f0fddf0b843489dc6b
ToppCell3'-Pediatric_IBD-SmallIntestine-Hematopoietic-Myeloid-MMP9+_Inflammatory_macrophage|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract

P2RY13 SLC8A1 CETP FPR3

4.44e-051954545a7c74f96f213c504abd65e751800da7e03e47d9
ToppCellILEUM-non-inflamed-(3)_moDC|non-inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

ZMYND15 P2RY13 SLC8A1 FPR3

4.53e-05196454e10f01172fd076d6892906853f9375d4c3058951
ToppCellMid-temporal_gyrus_(MTG)-Neuronal|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

XKR4 SLC35F3 SCN2A SCN8A

4.53e-05196454676c56b44ac29f7baecb62f49bb8597cc74c0a88
ToppCell(05)_Secretory-(0)_Reference|(05)_Secretory / shred by cell type by condition

CTAGE15 CTAGE6 CLCN2 PKD1L1

4.53e-051964547cb79cf122852c971f2d6e8d1e2b26eade891e83
ToppCellbackground-Kupffer_cells|background / Sample and Cell Type and Tumor Cluster (all cells)

P2RY13 SLC8A1 CETP FPR3

4.62e-051974548b45c7ecc18d188abc8c172d9bf881c95617a46a
ToppCellBrain_organoid-organoid_Kanton_Nature-Organoid-2M-Neuronal-ventral_progenitors_and_neurons_1|Organoid-2M / Sample Type, Dataset, Time_group, and Cell type.

SLC8A1 XKR4 SERINC1 SCN2A

4.62e-051974544961f66606f08e399508fd6cabca588e7ab406a8
ToppCell10x5'-GI_small-bowel-Myeloid_Mac|GI_small-bowel / Manually curated celltypes from each tissue

P2RY13 SLC8A1 CETP FPR3

4.71e-05198454748db69d3c9774e44c0cc425d937d18b83af8312
ToppCelldistal-3-Hematologic-Myeloid_Dendritic_Type_2|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

P2RY13 SLC8A1 CLCN5 FPR3

4.71e-051984548e5ac110278461af6eceec1e04de02df8430d1d7
ToppCelldistal-Hematologic-Myeloid_Dendritic_Type_2-3|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

P2RY13 SLC8A1 CLCN5 FPR3

4.71e-05198454984b3753fabd5553f6f364f90a422b035e421535
ToppCellNeuron-Postmitotic-Excitatory_Neuron_-Layer_IV-2|World / Primary Cells by Cluster

SLC8A1 XKR4 SERINC1 SCN2A

4.80e-05199454f09b40245d3d826275bbe5f508dedccc75a911bd
ToppCellbackground-Kupffer_cells|World / Sample and Cell Type and Tumor Cluster (all cells)

P2RY13 SLC8A1 CETP FPR3

4.80e-0519945491d229f3515d49639bcb5505e6aec4a9abade81c
ToppCell3'_v3-GI_small-bowel-Myeloid_Mac|GI_small-bowel / Manually curated celltypes from each tissue

P2RY13 SLC8A1 CETP FPR3

4.80e-051994548990a3d69e24cb3aaba9d6def3d0be9ee973436d
ToppCellmLN-(6)_Macrophage-(60)_Macrophage|mLN / shred on region, Cell_type, and subtype

ZMYND15 P2RY13 CETP FPR3

4.80e-051994541ea28b832c6173b1b58da432aaf21e6cd291561e
ToppCell3'_v3-GI_small-bowel-Myeloid_Mac-Intestinal_macrophages|GI_small-bowel / Manually curated celltypes from each tissue

P2RY13 SLC8A1 CETP FPR3

4.80e-0519945496070b5ffcbab4952970f43b536969ddd2ca5d14
ToppCellBrain_organoid-organoid_Kanton_Nature-Organoid-2M-Neuronal|Organoid-2M / Sample Type, Dataset, Time_group, and Cell type.

SLC8A1 CLCN4 XKR4 SCN2A

4.80e-051994545de2a32bc2e9c752eb19a013b1807949153728fc
ToppCellNeuron-Postmitotic-Excitatory_Neuron_-Layer_IV|World / Primary Cells by Cluster

SLC8A1 XKR4 SERINC1 SCN2A

4.80e-05199454e45448ec4db8875c8aaa9aad109a10e2905a4226
ToppCell(5)_Dendritic_cell|World / shred on Cell_type and subtype

ZMYND15 P2RY13 SLC8A1 FPR3

4.80e-05199454495de74a918c5c625a2d0ef120fe4162d4ce6e76
ToppCellCaecum-Dendritic_cell-cDC1|Caecum / Region, Cell class and subclass

ZMYND15 SLC8A1 CLCN1 CLCN4

4.80e-051994549ab38a0060a883de6fe3da8cdac42e124d7981d9
ToppCellmLN-Macrophage-Macrophage|mLN / Region, Cell class and subclass

ZMYND15 P2RY13 CETP FPR3

4.80e-051994546bbec8450afb30347b07da28401a698fc51a3c53
ToppCellCaecum-(5)_Dendritic_cell-(51)_cDC1|Caecum / shred on region, Cell_type, and subtype

ZMYND15 SLC8A1 CLCN1 CLCN4

4.80e-051994542b97fda45241b2ce7be904cf081cabcf3eb5ba1d
ToppCellNeuron-Postmitotic-Excitatory_Neuron_-Upper_Layer|World / Primary Cells by Cluster

SLC8A1 XKR4 SERINC1 SCN2A

4.89e-05200454db10f76938af553d1a2275bb02ef75dff3c3135b
ToppCellNeuron-Postmitotic-Excitatory_Neuron_-Upper_Layer-21|World / Primary Cells by Cluster

SLC8A1 XKR4 SERINC1 SCN2A

4.89e-0520045430a3e4aee12ec1b5acdce90f86c9733c27a7f6fc
ToppCellmLN-Macrophage|mLN / Region, Cell class and subclass

P2RY13 SLC8A1 CETP FPR3

4.89e-0520045468d709afd226241e002dae6d6820bccd1cfd87a1
ToppCellParenchymal-10x5prime-Immune_Myeloid-Dendritic_cell-DC_2|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

P2RY13 SLC8A1 FPR3 TRPC6

4.89e-05200454f0e7c2f07a7065511bf0b6521ce2e74e04e48544
ToppCellsevere-Non-classical_Monocyte|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

ZMYND15 P2RY13 SLC8A1 CETP

4.89e-052004546cc7190a4ffc6c06335072f3b5b5f98eae36e2ce
ToppCellNeuronal|World / cells hierarchy compared to all cells using T-Statistic

XKR4 SLC35F3 SCN2A SCN8A

4.89e-0520045448d801219bc771d6c7e151dc88ca4c179988de85
ToppCellsevere-Non-classical_Monocyte|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

ZMYND15 P2RY13 SLC8A1 CETP

4.89e-05200454804c6e998fb7a29ca1b98f53d5dbcb7ae5a47e7a
ToppCellmLN-(6)_Macrophage|mLN / shred on region, Cell_type, and subtype

P2RY13 SLC8A1 CETP FPR3

4.89e-052004546dcba82a7d322102bae205543086e84c7655b3e0
ToppCellLPS_only-Myeloid-Dendritic_cells-Monocytes-Macrophages|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ZMYND15 CLCN5 FPR3

1.97e-041124539801227fe5a6f5ae1b6c5a9e7fa7f35c4c52efe1
ToppCelldroplet-Lung-nan-3m-Myeloid-intermediate_monocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PAPOLB RMND1 PKD1L2

4.05e-041434534d11d53330a9197275a8851e1bbf55a113715a09
ToppCelldroplet-Lung-nan-3m-Myeloid-Intermediate_Monocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PAPOLB RMND1 PKD1L2

4.05e-041434538b9f4d87d5faac7752c83e1992491fc5550600f8
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Outer_Medullary_Collecting_Duct_Principal_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CTAGE9 SLC16A14 SCN2A

4.21e-04145453fd02d55755c35288a42ab08a82450b370aad35a7
ToppCellE18.5-samps-Mesenchymal-Myofibroblast-MyoFB-1|E18.5-samps / Age Group, Lineage, Cell class and subclass

SLC8A2 XKR4 SYNGR3

4.21e-04145453ac41c6c02b7d78162b86222983688f54d04ac47d
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Intercalated_Cell_Type_B|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

NLRP9 SLC35F3 SYNGR3

4.56e-0414945361d84838a841ed2d6b8c5f86d423a4e6b3dcc9cb
ToppCellSmart-seq2-lymph_node_(Smart-seq2)-myeloid-myeloid_dendritic|lymph_node_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

SLC8A1 CLCN1 FPR3

4.65e-04150453f4aed24b79e1be38abc7a1120256821601893d6d
ToppCelldroplet-Lung-nan-3m-Myeloid-dendritic_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ZMYND15 PAPOLB CLCN2

4.83e-0415245377b319f594d5e4df29034bbf69c7490076f89dd3
ToppCellPBMC-Mild-Myeloid-cDC-cDC-cDC_4|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

RMND1 CLCN5 SMIM10

4.93e-0415345391e9d70a5d3f6fd68c284ed0cc113f03d7d1e10b
ToppCellPBMC-Mild-Myeloid-cDC-cDC-cDC_4|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

RMND1 CLCN5 SMIM10

4.93e-04153453f17f62646633cf95c810dcd5328978058741b276
ToppCellSmart-seq2-lymph_node_(Smart-seq2)-myeloid-myeloid_monocytic-classical_monocyte|lymph_node_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

ZMYND15 P2RY13 CNTNAP1

5.02e-04154453c6ecc46b99a783373729f7fae0b23216148ffb78
ToppCelldroplet-Liver-Hepatocytes-24m-Myeloid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PAPOLB FANCB SLC8A1

5.31e-04157453ec433d2fe827abdb647be4176c231b7052482b6f
ToppCellPBMC-Severe-Myeloid-cDC-cDC-cDC_1|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

SLC8A1 CLCN5 FPR3

5.31e-04157453e9d0300361b06aec3c216f8af15f09e14b12a4da
ToppCellfacs-Brain_Non-Myeloid-Hippocampus_-18m-Myeloid-microglial_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CLCN1 PKD1L2 SLC16A14

5.31e-04157453c762b03e254c73222094725ca8ac1c8eb428bccb
ToppCellfacs-Brain_Non-Myeloid-Hippocampus_-18m-Myeloid-nan|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CLCN1 PKD1L2 SLC16A14

5.31e-041574536b5b08bb5520fcf6f4c0560f7ed7645ec179806d
ToppCellfacs-Brain_Non-Myeloid-Hippocampus_-18m-Myeloid|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CLCN1 PKD1L2 SLC16A14

5.31e-041574537fdc0094dd5729990a91a30c1982a14c74650b52
ToppCellPBMC-Severe-Myeloid-cDC-cDC-cDC_1|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

SLC8A1 CLCN5 FPR3

5.41e-04158453e9657d8960d499832f9f9b45b5a6f4388551b7e1
ToppCellControl-APC-like-Monocyte-derived_macrophages|Control / group, cell type (main and fine annotations)

P2RY13 SLC8A1 RMND1

5.61e-04160453463dd624ca5c375b6ff7c269f4ef4b9d74f4b669
ToppCellfacs-Spleen-nan-3m-Hematologic|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ZMYND15 SLC8A2 SLC8A1

5.72e-0416145345591addc765760db6029ac19e80573373d1d917
ToppCellfacs-Spleen-nan-3m-Hematologic-nan|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ZMYND15 SLC8A2 SLC8A1

5.72e-041614538741b91a62c9a8ce377ef6533d323b65beb93c63
ToppCellfacs-Spleen-nan-3m-Hematologic-proerythroblast|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ZMYND15 SLC8A2 SLC8A1

5.72e-041614539cf1dcf0e7ca9e35c46c094a6b78f98d1f6b9276
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Principal_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SLC8A1 CTAGE6 SCN2A

5.82e-04162453285e6d553f485fd9f1075c4e1b940da251b5ea35
ToppCelldroplet-Liver-Hepatocytes-24m-Myeloid-Kupffer_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PAPOLB FANCB SLC8A1

5.92e-041634538dc0128eeede933537e3bcc5d6ec0322711552f3
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Myeloid-Dendritic-conventional_dendritic_cell-DC_c1-CLEC9A|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

P2RY13 CLCN5 SCN8A

5.92e-04163453f4fcac0af9967ec34a43c9674aa17b0aa5344cf6
ToppCelldroplet-Liver-Hepatocytes-24m-Myeloid-Kupffer_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PAPOLB FANCB SLC8A1

5.92e-04163453fd243ca223079033be480a24817a399f281fa4d4
ToppCell368C-Myeloid-Dendritic-cDC1|Dendritic / Donor, Lineage, Cell class and subclass (all cells)

CLCN1 CLCN2 CLCN4

5.92e-04163453299ac2463b7f58eee419d822a2a2d64b973d87e9
ToppCell10x_3'_v3-thymus_(10x_3'_v3)-myeloid-myeloid_dendritic-dendritic_cell|thymus_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

ZMYND15 P2RY13 SLC8A1

6.03e-041644533088d5fa240d2f4a6e21281f7ac932aea2f9af49
ToppCelldroplet-Lung-nan-3m-Myeloid-Ccr7+_Dendritic|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ZMYND15 PAPOLB CLCN2

6.03e-0416445378de403446fe0eb375c82ff1832cc5fbb8e20afa
ToppCelldroplet-Lung-3m-Hematologic-myeloid-myeloid_dendritic_cell-Ccr7+_dendritic|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ZMYND15 PAPOLB CLCN2

6.14e-04165453c39f0479955c4e23921f7a450d3bc251a002200f
ToppCell5'-Adult-Appendix-Hematopoietic-Myeloid-cDC2|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TVP23C P2RY13 SLC8A1

6.36e-041674531bd0aa7a3c8649f342bb856cf861c4c5984ad889
ToppCellcontrol-Epithelial-Ionocyte|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

XKR4 SLC35F3 SYNGR3

6.47e-04168453327b02f19f4a8607c033203824fdc60a1254331f
ToppCellfacs-Large_Intestine-Proximal-3m-Epithelial-Enterocyte_(Proximal)|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC8A1 CLCN2 SLC35F5

6.81e-041714535d0d6c1ff610a703ae0b834a12823c5ff9012932
ToppCellmetastatic_Lymph_Node-Myeloid_cells-pDCs|metastatic_Lymph_Node / Location, Cell class and cell subclass

CLCN5 SLC35F3 CNTNAP1

6.81e-041714531f8e66073088fc1969782e443bf00f8c1877ea91
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Monocytic-Monocyte-derived_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

P2RY13 SLC8A1 FPR3

6.92e-0417245372fbfa890995e47048b47199c170cc7dcd7661f8
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Monocytic|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

P2RY13 SLC8A1 FPR3

6.92e-041724532ca6f0d1181aabe0d0e3e8f2e193f08dbda42dea
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SLC8A1 TIMM23B SCN2A

7.04e-041734534bc6d93716f093b460c8b047199db8cab5fea720
ToppCell5'-Adult-Distal_Rectal-Hematopoietic|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

P2RY13 FPR3 SCN8A

7.04e-04173453b335ca2a247156eba821943b2b9fc9922230b409
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L5-6_PVALB_FAM150B|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CTAGE9 CTAGE4 TRPC6

7.16e-04174453cc4c7f00a25a7814b52d4599166615daa140cc31
ToppCellDendritic_Cells-IPF_02|World / lung cells shred on cell class, cell subclass, sample id

P2RY13 SLC8A1 FPR3

7.28e-04175453584290a51f9975782a5ac8c6ad67c778d8323f8c
ToppCellCV-Mild-6|Mild / Virus stimulation, Condition and Cluster

DEPDC5 MYCBPAP TIMM23B

7.28e-04175453c4d530dbb37942427c9cd0a1533faeb6a3a45381
ToppCellControl-Lymphoid-pDC|Control / Condition, Lineage and Cell class

SLC35F3 CETP CNTNAP1

7.40e-041764535de16ff65476bde8b23322a44e11412e14f1bafe
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Degenerative_Connecting_Tubule_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

TVP23C SLC8A1 SCN2A

7.40e-04176453b942227abf9902ba13fac6c3e9efb0cacc82af94
Drug1-phenylpyrazole

CLCN1 CLCN2 CLCN3 CLCN4 CLCN5

1.80e-0928435CID000070769
Druglubiprostone

CLCN1 CLCN2 CLCN3 CLCN4 CLCN5

2.18e-0845435CID000157920
Drugantineutrophil cytoplasmic antibody

CLCN1 CLCN2 CLCN3 CLCN4 CLCN5

4.60e-0852435CID000002201
Drugfipronil

CLCN1 CLCN2 CLCN3 CLCN4 CLCN5

1.04e-0761435CID000003352
Drugniflumic acid

CLCN1 CLCN2 CLCN3 CLCN4 CLCN5 TRPC6

1.25e-07125436CID000004488
Drugpicrotoxinine

CLCN1 CLCN2 CLCN3 CLCN4 CLCN5

1.44e-0765435CID000004816
Drugtrans-4-aminocrotonic acid

CLCN1 CLCN2 CLCN3 CLCN4 CLCN5

1.67e-0767435CID000002766
DrugBN 52021

CLCN1 CLCN2 CLCN3 CLCN4 CLCN5

2.58e-0773435CID000065243
DrugTBPS

CLCN1 CLCN2 CLCN3 CLCN4 CLCN5

6.23e-0787435CID000104781
Drugivermectin

CLCN1 CLCN2 CLCN3 CLCN4 CLCN5

1.31e-06101435CID006435110
DrugAC1L1DN5

CLCN1 CLCN2 CLCN3 CLCN4 CLCN5

1.37e-06102435CID000002423
Drughexamethylmelamine

CLCN1 CLCN2 CLCN3 CLCN4 CLCN5

1.37e-06102435CID000002123
DrugAC1L1D9R

CLCN1 CLCN2 CLCN3 CLCN4 CLCN5

1.44e-06103435CID000002254
Drugendrine

CLCN1 CLCN2 CLCN3 CLCN4 CLCN5

1.66e-06106435CID000003048
Drugoxotremorine

CLCN1 CLCN2 CLCN3 CLCN4 CLCN5

1.82e-06108435CID000004630
Drug4,4'-diisothiocyanostilbene-2,2'-disulfonic acid

P2RY13 CLCN1 CLCN2 CLCN3 CLCN4 CLCN5

2.35e-06206436CID000040600
Drugtrans-1,2-diphenylethylene

CLCN1 CLCN2 CLCN3 CLCN4 CLCN5

2.71e-06117435CID000011502
Drugibotenic acid

CLCN1 CLCN2 CLCN3 CLCN4 CLCN5

3.33e-06122435CID000001233
DrugAC1NRA5C

CLCN1 CLCN2 CLCN3 CLCN4 CLCN5

1.87e-05174435CID005287709
DrugSodium

SLC8A1 SCN2A TRPC6 SCN8A

1.91e-0584434ctd:D012964
Drugcyclamate

CLCN1 CLCN3 CLCN5

1.99e-0528433CID000007533
DrugAPETx2 protein, Anthopleura elegantissima

SCN2A SCN8A

2.09e-054432ctd:C501880
Drugpicrotoxin

CLCN1 CLCN2 CLCN3 CLCN4 CLCN5

2.26e-05181435CID000031304
DrugAPETx1, Anthopleura elegantissima

SCN2A SCN8A

5.20e-056432ctd:C475726
DrugChlorides

CLCN1 CLCN2 CLCN3

6.84e-0542433ctd:D002712
Drugtaurine

CLCN1 CLCN2 CLCN3 CLCN4 CLCN5

7.24e-05231435CID000001123
Drug2,3,5,6-tetrafluoro-4-methylbenzyl (Z)-(1RS)-cis-3-(2-chloro-3,3,3-trifluoroprop-1-enyl)-2,2-dimethylcyclopropanecarboxylate

SCN2A SCN8A

9.69e-058432ctd:C489827
Drugcalcium oxide

FANCB SLC8A2 SLC8A1

1.02e-0448433CID000014778
DrugLS-63783

FANCB CLCN1 CLCN2 CLCN3 CLCN4 CLCN5 FPR3 TRPC6

1.13e-04804438CID000000231
DrugAC1Q3ZOL

CLCN1 CLCN2 CLCN3 CLCN4 CLCN5

1.22e-04258435CID000002376
Drugphorbol 12-myristate

CLCN2 CLCN3 CLCN4 CLCN5 FPR3

1.28e-04261435CID000107854
Drug5-nitro-2-(3-phenylpropylamino)benzoic acid

CLCN2 CLCN3 CLCN5

1.30e-0452433CID000004549
DrugHgCl2

CLCN1 CLCN2 CLCN3 CLCN4 CLCN5

1.33e-04263435CID000024085
Drugfurosemide

CLCN1 CLCN2 CLCN3 CLCN4 CLCN5

1.56e-04272435CID000003440
Drug9-3a

SLC8A2 SLC8A1

1.90e-0411432CID011963492
Drugmethylglucamine

SLC8A2 TRPC6 SCN8A

2.20e-0462433CID000004049
DiseaseDent disease (implicated_via_orthology)

CLCN3 CLCN4 CLCN5

1.67e-093363DOID:0050699 (implicated_via_orthology)
Diseaseosteopetrosis (implicated_via_orthology)

CLCN3 CLCN4 CLCN5

5.82e-087363DOID:13533 (implicated_via_orthology)
DiseaseBenign familial infantile epilepsy

SCN2A SCN8A

4.34e-063362cv:C5575231
DiseaseFamilial benign neonatal epilepsy

SCN2A SCN8A

2.16e-056362C0220669
Diseasegeneralized epilepsy with febrile seizures plus 2 (implicated_via_orthology)

SCN2A SCN8A

6.47e-0510362DOID:0111294 (implicated_via_orthology)
DiseaseDravet syndrome (implicated_via_orthology)

SCN2A SCN8A

6.47e-0510362DOID:0080422 (implicated_via_orthology)
DiseaseMalignant Glioma

CLCN2 CLCN3 CLCN5

8.63e-0570363C0555198
Diseasemixed gliomas

CLCN2 CLCN3 CLCN5

8.63e-0570363C0259783
Diseasegeneralized epilepsy with febrile seizures plus (implicated_via_orthology)

SCN2A SCN8A

9.48e-0512362DOID:0060170 (implicated_via_orthology)
DiseaseGlioma

CLCN2 CLCN3 CLCN5

1.65e-0487363C0017638
DiseaseRenal glomerular disease

CLCN5 TRPC6

3.60e-0423362C0268731
DiseaseGlomerulopathy Assessment

CLCN5 TRPC6

3.60e-0423362C4521256
Diseaseepilepsy (implicated_via_orthology)

DEPDC5 SCN2A SCN8A

1.03e-03163363DOID:1826 (implicated_via_orthology)

Protein segments in the cluster

PeptideGeneStartEntry
WFSERVFHSLAKVAF

CETP

281

P11597
VSRSLWDVFAFSFKT

CNTNAP1

191

P78357
GFFVVLLFLWRSFRS

CTAGE4

51

Q8IX94
GFFVVLLFLWRSFRS

CTAGE6

51

Q86UF2
GFFVVLLFLWRSFRS

CTAGE8

51

P0CG41
GFFVVLLFLWRSFRS

CTAGE9

51

A4FU28
GFFVVLLFLWRSFRS

CTAGE15

51

A4D2H0
LWRSFFAALVAAFTL

CLCN4

291

P51793
FFKWSSRVFKNVAVI

IREB2

231

P48200
FLACSNFWFKFPRTS

LRRC8A

136

Q8IWT6
ASTLVRKFFLVFSEW

PAPOLB

266

Q9NRJ5
FASFQRKWFEVAFVA

DEPDC5

1286

O75140
TVTRTYLFLHKFWFF

LMBRD1

476

Q9NUN5
RVFAAVVASFFICWF

FPR3

241

P25089
LSLIIGLRKTFWFFF

GOLT1A

46

Q6ZVE7
VLGFREFFKWANTTL

PKD1L2

1991

Q7Z442
KTVSIFIWFFLFFIS

P2RY13

161

Q9BPV8
LILWRHVKAFFFISS

FANCB

141

Q8NB91
KTLWRSFFAALVAAF

CLCN5

346

P51795
VTFNFTSFKSVLRGW

ERVFC1

66

P60507
FRFVHISWVSFKDTF

PKD1L1

891

Q8TDX9
AVVGFFAVLFFLWRS

MIA2

656

Q96PC5
FAVLFFLWRSFRSVR

MIA2

661

Q96PC5
AKISFFFCFVWFLAN

SLC35F5

241

Q8WV83
FTNRMFVAFIFWALF

SLC16A14

311

Q7RTX9
IFFFREGAAVFWNVK

RMND1

226

Q9NWS8
FRKFDAPFTLTWFAT

SLC35F3

91

Q8IY50
WFFKFAAAIAIIIGA

SERINC1

126

Q9NRX5
RTFVAFAAKLWSFFI

CTDNEP1

11

O95476
FSAFVFRVLAVWNKD

CLCN1

311

P35523
AATFSAFIFRVLAVW

CLCN2

281

P51788
FWALSFAFLAVSLVK

CLCN3

216

P51790
EGNLWKDRFTFVFFL

NLRP9

171

Q7RTR0
FAFSALFSFTVKWLR

TVP23C

141

Q96ET8
FVLTRRFSSLKTFLW

SUN2

201

Q9UH99
SFDTFSWAFLSLFRL

SCN2A

366

Q99250
FCWHFFTIAARVITF

XKR4

376

Q5GH76
FFFKSLTAGVFREFW

MYCBPAP

501

Q8TBZ2
TSFDTFSWAFLALFR

SCN8A

351

Q9UQD0
ANKTWGRFELAFFTI

TIMM23B

66

Q5SRD1
ARAAIAFSFFSILSW

SYNGR3

146

O43761
LTFFDLAWRLRKNFF

SMIM10

51

Q96HG1
FAFSALFSFRVKWLA

TVP23B

141

Q9NYZ1
IFAASFIARFMAFWH

TRPC6

536

Q9Y210
FLDFTALLFGWFRKF

ZMYND15

11

Q9H091
LRVFFVTAAWSIFAY

SLC8A1

201

P32418
RVFFVTASWSIFAYV

SLC8A2

196

Q9UPR5