Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	tubulin binding	FMR1 CKAP5 DNM3 DLEC1 CAMSAP2 PSRC1 CFAP157	3.89e-04	428	63	7	GO:0015631
GeneOntologyMolecularFunction	microtubule binding	FMR1 CKAP5 DNM3 CAMSAP2 PSRC1 CFAP157	4.17e-04	308	63	6	GO:0008017
GeneOntologyMolecularFunction	unmethylated CpG binding	KMT2B KDM2B	4.34e-04	10	63	2	GO:0045322
GeneOntologyMolecularFunction	cytoskeletal protein binding	TAOK2 TLNRD1 MICAL1 FMR1 CKAP5 DNM3 DLEC1 CAMSAP2 EP300 PSRC1 CFAP157	5.88e-04	1099	63	11	GO:0008092
GeneOntologyMolecularFunction	cAMP response element binding protein binding	CRTC3 CRTC1	6.34e-04	12	63	2	GO:0008140
GeneOntologyCellularComponent	neuronal ribonucleoprotein granule	FMR1 CKAP5	3.96e-04	10	63	2	GO:0071598
GeneOntologyCellularComponent	chaperonin-containing T-complex	CCT8L2 CCT8L1P	4.83e-04	11	63	2	GO:0005832
GeneOntologyCellularComponent	endoplasmic reticulum-plasma membrane contact site	GRAMD1B GRAMD1A	6.82e-04	13	63	2	GO:0140268
GeneOntologyCellularComponent	dendrite	TAOK2 FMR1 SHANK2 HCN4 CKAP5 DNM3 CRTC1 EEF2K INPP5J	1.03e-03	858	63	9	GO:0030425
GeneOntologyCellularComponent	dendritic tree	TAOK2 FMR1 SHANK2 HCN4 CKAP5 DNM3 CRTC1 EEF2K INPP5J	1.04e-03	860	63	9	GO:0097447
GeneOntologyCellularComponent	dendritic spine head	FMR1 DNM3	1.04e-03	16	63	2	GO:0044327
GeneOntologyCellularComponent	interstitial matrix	COL14A1 ADAMTSL4	1.18e-03	17	63	2	GO:0005614
Domain	Znf_CXXC	KMT2B TET1 KDM2B	5.11e-06	11	60	3	IPR002857
Domain	ZF_CXXC	KMT2B TET1 KDM2B	5.11e-06	11	60	3	PS51058
Domain	zf-CXXC	KMT2B TET1 KDM2B	5.11e-06	11	60	3	PF02008
Domain	GRAM	TBC1D8 GRAMD1B GRAMD1A	1.71e-05	16	60	3	SM00568
Domain	TORC_N	CRTC3 CRTC1	3.04e-05	3	60	2	IPR024783
Domain	TORC	CRTC3 CRTC1	3.04e-05	3	60	2	IPR024786
Domain	TORC_M	CRTC3 CRTC1	3.04e-05	3	60	2	IPR024784
Domain	TORC_C	CRTC3 CRTC1	3.04e-05	3	60	2	IPR024785
Domain	TORC_N	CRTC3 CRTC1	3.04e-05	3	60	2	PF12884
Domain	TORC_M	CRTC3 CRTC1	3.04e-05	3	60	2	PF12885
Domain	TORC_C	CRTC3 CRTC1	3.04e-05	3	60	2	PF12886
Domain	VAST	GRAMD1B GRAMD1A	3.04e-05	3	60	2	PS51778
Domain	DUF4782	GRAMD1B GRAMD1A	3.04e-05	3	60	2	IPR031968
Domain	DUF4782	GRAMD1B GRAMD1A	3.04e-05	3	60	2	PF16016
Domain	GRAM	TBC1D8 GRAMD1B GRAMD1A	4.65e-05	22	60	3	PF02893
Domain	GRAM	TBC1D8 GRAMD1B GRAMD1A	4.65e-05	22	60	3	IPR004182
Domain	K_chnl_volt-dep_EAG/ELK/ERG	HCN4 KCNH2	9.01e-04	14	60	2	IPR003938
Domain	PH_dom-like	PHLDB1 RAPH1 DNM3 IRS1 LRBA ARHGEF17	2.41e-03	426	60	6	IPR011993
Domain	CNMP_BINDING_1	HCN4 KCNH2	4.73e-03	32	60	2	PS00888
Domain	CNMP_BINDING_2	HCN4 KCNH2	4.73e-03	32	60	2	PS00889
Domain	cNMP	HCN4 KCNH2	5.33e-03	34	60	2	SM00100
Domain	cNMP_binding	HCN4 KCNH2	5.33e-03	34	60	2	PF00027
Domain	cNMP-bd_dom	HCN4 KCNH2	5.64e-03	35	60	2	IPR000595
Domain	CNMP_BINDING_3	HCN4 KCNH2	5.64e-03	35	60	2	PS50042
Domain	PH	PHLDB1 RAPH1 DNM3 IRS1	6.28e-03	229	60	4	PF00169
Domain	cNMP-bd-like	HCN4 KCNH2	6.62e-03	38	60	2	IPR018490
Domain	Kinase-like_dom	TAOK2 RAPH1 MAP4K1 DCLK3 DNM3 EEF2K	7.73e-03	542	60	6	IPR011009
Domain	-	PHLDB1 RAPH1 DNM3 IRS1 ARHGEF17	8.34e-03	391	60	5	2.30.29.30
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	TBC1D10B CRTC3 PHLDB1 RAPH1 TTC28 MAP4K1 TET1 CKAP5 CRTC1 IRS1 ARHGEF17 CAMSAP2 CIC	4.01e-09	861	63	13	36931259
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	KMT2B NUP107 RAPH1 TTC28 TET1 CKAP5 KDM2B CRTC1 LRBA CIC	4.09e-09	418	63	10	34709266
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	TAOK2 ENGASE TLNRD1 PHLDB1 KMT2B SHANK2 LMX1B KCNH2 MTG2 FRMD8 IRS1 LRBA CIC EP300	8.62e-09	1105	63	14	35748872
Pubmed	Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening.	KMT2B SHANK2 HCN4 MAP4K1 CKAP5 DNM3 LRBA CDC27	1.45e-07	329	63	8	17474147
Pubmed	DNA Sequence Recognition of Human CXXC Domains and Their Structural Determinants.	KMT2B TET1 KDM2B	6.74e-07	10	63	3	29276034
Pubmed	FMRP promotes transcription-coupled homologous recombination via facilitating TET1-mediated m5C RNA modification demethylation.	FMR1 TET1	3.23e-06	2	63	2	35290126
Pubmed	Aster Proteins Regulate the Accessible Cholesterol Pool in the Plasma Membrane.	GRAMD1B GRAMD1A	3.23e-06	2	63	2	32719109
Pubmed	Overlapping Activities of Two Neuronal Splicing Factors Switch the GABA Effect from Excitatory to Inhibitory by Regulating REST.	GRAMD1B SHANK2 GRAMD1A CKAP5 DNM3	3.70e-06	128	63	5	30995482
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	GRAMD1B PHLDB1 TTC28 CKAP5 DNM3 ARHGEF17 CAMSAP2	8.99e-06	407	63	7	12693553
Pubmed	Epigenomic analysis of gastrulation identifies a unique chromatin state for primed pluripotency.	KMT2B TET1	9.68e-06	3	63	2	31844322
Pubmed	Cutaneous hidradenoma: a study of 21 neoplasms revealing neither correlation between the cellular composition and CRTC1-MAML2 fusions nor presence of CRTC3-MAML2 fusions.	CRTC3 CRTC1	9.68e-06	3	63	2	27402217
Pubmed	Elongation factor 2 and fragile X mental retardation protein control the dynamic translation of Arc/Arg3.1 essential for mGluR-LTD.	FMR1 EEF2K	9.68e-06	3	63	2	18614030
Pubmed	Impact of CRTC1/3-MAML2 fusions on histological classification and prognosis of mucoepidermoid carcinoma.	CRTC3 CRTC1	9.68e-06	3	63	2	21668476
Pubmed	CRTC1-MAML2 and CRTC3-MAML2 fusions were not detected in metaplastic Warthin tumor and metaplastic pleomorphic adenoma of salivary glands.	CRTC3 CRTC1	9.68e-06	3	63	2	24121173
Pubmed	Role of Polymorphisms of FAM13A, PHLDB1, and CYP24A1 in Breast Cancer Risk.	PHLDB1 CYP24A1	9.68e-06	3	63	2	31215377
Pubmed	"Pancreatic Mucoepidermoid Carcinoma" Is not a Pancreatic Counterpart of CRTC1/3-MAML2 Fusion Gene-related Mucoepidermoid Carcinoma of the Salivary Gland, and May More Appropriately be Termed Pancreatic Adenosquamous Carcinoma With Mucoepidermoid Carcinoma-like Features.	CRTC3 CRTC1	9.68e-06	3	63	2	30138216
Pubmed	Correlation of Crtc1/3-Maml2 fusion status, grade and survival in mucoepidermoid carcinoma.	CRTC3 CRTC1	9.68e-06	3	63	2	28438292
Pubmed	TORCs: transducers of regulated CREB activity.	CRTC3 CRTC1	9.68e-06	3	63	2	14536081
Pubmed	Neurobeachin, a protein implicated in membrane protein traffic and autism, is required for the formation and functioning of central synapses.	DNM3 SYN2 LRBA	1.61e-05	27	63	3	19723784
Pubmed	A Cdh1-APC/FMRP Ubiquitin Signaling Link Drives mGluR-Dependent Synaptic Plasticity in the Mammalian Brain.	FMR1 CDC27	1.93e-05	4	63	2	25913861
Pubmed	Analysis of a cAMP regulated coactivator family reveals an alternative phosphorylation motif for AMPK family members.	CRTC3 CRTC1	1.93e-05	4	63	2	28235073
Pubmed	Transducer of regulated CREB-binding proteins (TORCs) induce PGC-1alpha transcription and mitochondrial biogenesis in muscle cells.	CRTC3 CRTC1	1.93e-05	4	63	2	16980408
Pubmed	Identification of a family of cAMP response element-binding protein coactivators by genome-scale functional analysis in mammalian cells.	CRTC3 CRTC1	1.93e-05	4	63	2	14506290
Pubmed	Proteins recruited by SH3 domains of Ruk/CIN85 adaptor identified by LC-MS/MS.	PHLDB1 RAPH1 CDC27 PSRC1	4.55e-05	108	63	4	19531213
Pubmed	Aster Proteins Facilitate Nonvesicular Plasma Membrane to ER Cholesterol Transport in Mammalian Cells.	GRAMD1B GRAMD1A	4.82e-05	6	63	2	30220461
Pubmed	Hypoxia switches TET1 from being tumor-suppressive to oncogenic.	TET1 EP300	4.82e-05	6	63	2	37020036
Pubmed	Transforming activity of MECT1-MAML2 fusion oncoprotein is mediated by constitutive CREB activation.	CRTC1 EP300	4.82e-05	6	63	2	15961999
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	KMT2B RAPH1 TTC28 TET1 KDM2B LRBA EP300	6.06e-05	549	63	7	38280479
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	SEC16B TBC1D10B KMT2B RAPH1 MAP4K1 CKAP5 KDM2B CIC	7.63e-05	774	63	8	15302935
Pubmed	Mitogenic Signals Stimulate the CREB Coactivator CRTC3 through PP2A Recruitment.	CRTC3 CRTC1	8.98e-05	8	63	2	30611118
Pubmed	A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning.	CRTC3 PHLDB1 SHANK2 RAPH1 CRTC1 EEF2K CDC27 CAMSAP2 PSRC1	1.01e-04	1038	63	9	26673895
Pubmed	A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance.	SYN2 KDM2B IRS1	1.39e-04	55	63	3	22581228
Pubmed	New nomenclature for chromatin-modifying enzymes.	KMT2B KDM2B EP300	1.55e-04	57	63	3	18022353
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	TBC1D10B ZNF526 SOWAHA FMR1 NUP107 TTC28 HRES1 CDC27 EP300	1.74e-04	1116	63	9	31753913
Pubmed	Extracellular matrix signatures of human primary metastatic colon cancers and their metastases to liver.	SEMA3B EMILIN2 COL14A1 ADAMTSL4	1.75e-04	153	63	4	25037231
Pubmed	Expression QTL and regulatory network analysis of microtubule-associated protein tau gene.	SYN2 EEF2K	1.76e-04	11	63	2	19233709
Pubmed	Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.	TAOK2 GRAMD1B FMR1 SHANK2 HCN4 GRAMD1A CKAP5 SYN2 CAMSAP2	2.03e-04	1139	63	9	36417873
Pubmed	Advancing the understanding of autism disease mechanisms through genetics.	FMR1 SHANK2	2.49e-04	13	63	2	27050589
Pubmed	Interaction between the scaffold proteins CBP by IQGAP1 provides an interface between gene expression and cytoskeletal activity.	SEMA3B CAMSAP2 EP300	2.73e-04	69	63	3	32238831
Pubmed	Pacsin 2 is required for the maintenance of a normal cardiac function in the developing mouse heart.	HCN4 KCNH2	2.90e-04	14	63	2	29107716
Pubmed	Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.	TAOK2 CCDC14 TLNRD1 CRTC3 FMR1 CYP24A1 COL14A1 EP300 PSRC1	3.26e-04	1215	63	9	15146197
Pubmed	SET1 and p300 act synergistically, through coupled histone modifications, in transcriptional activation by p53.	KMT2B EP300	3.81e-04	16	63	2	23870121
Pubmed	JAKMIP1, a Novel Regulator of Neuronal Translation, Modulates Synaptic Function and Autistic-like Behaviors in Mouse.	FMR1 SHANK2	4.32e-04	17	63	2	26627310
Pubmed	Identification of the SOX2 Interactome by BioID Reveals EP300 as a Mediator of SOX2-dependent Squamous Differentiation and Lung Squamous Cell Carcinoma Growth.	KDM2B CIC EP300	4.69e-04	83	63	3	28794006
Pubmed	Severe acute respiratory syndrome coronavirus nonstructural protein 2 interacts with a host protein complex involved in mitochondrial biogenesis and intracellular signaling.	KMT2B CKAP5	4.85e-04	18	63	2	19640993
Pubmed	Identification of FMRP target mRNAs in the developmental brain: FMRP might coordinate Ras/MAPK, Wnt/β-catenin, and mTOR signaling during corticogenesis.	FMR1 EP300	4.85e-04	18	63	2	33323119
Pubmed	Shotgun sequencing of the human transcriptome with ORF expressed sequence tags.	TBC1D8 GRAMD1B SHANK2 ADAMTSL4 CIC PSRC1	4.91e-04	552	63	6	10737800
Pubmed	SR protein kinases promote splicing of nonconsensus introns.	SEC16B PHLDB1 RAPH1 CKAP5 CRTC1	5.03e-04	361	63	5	26167880
Pubmed	Comprehensive proteomic characterization of stem cell-derived extracellular matrices.	EMILIN2 COL14A1 ADAMTSL4	5.21e-04	86	63	3	28327460
Pubmed	HectD1 controls hematopoietic stem cell regeneration by coordinating ribosome assembly and protein synthesis.	FMR1 TTC28 CDC27	5.39e-04	87	63	3	33711283
Pubmed	Additive effect of multiple genetic variants on the risk of coronary artery disease.	IRS1 PSRC1	5.41e-04	19	63	2	20738937
Pubmed	BioID Performed on Golgi Enriched Fractions Identify C10orf76 as a GBF1 Binding Protein Essential for Golgi Maintenance and Secretion.	RAPH1 TTC28 CKAP5 LRBA	6.47e-04	216	63	4	31519766
Pubmed	Congenital heart defect causing mutation in Nkx2.5 displays in vivo functional deficit.	HCN4 KCNH2	6.63e-04	21	63	2	28302382
Pubmed	Broad histone H3K4me3 domains in mouse oocytes modulate maternal-to-zygotic transition.	KMT2B KDM2B	6.63e-04	21	63	2	27626377
Pubmed	Gene-environment interaction impacts on heart development and embryo survival.	HCN4 KCNH2	7.29e-04	22	63	2	30787001
Pubmed	Viral Infection-Induced Differential Expression of LncRNAs Associated with Collagen in Mouse Placentas and Amniotic Sacs.	GRAMD1B GRAMD1A ADAMTSL4	8.08e-04	100	63	3	26073538
Pubmed	Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	RAPH1 TET1 DCLK3	8.56e-04	102	63	3	11214970
Pubmed	Brugada Syndrome	HCN4 KCNH2	8.69e-04	24	63	2	20301690
Pubmed	Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.	PRDM10 NUP107 CKAP5 CHSY3 CDC27 CIC EP300	8.98e-04	857	63	7	25609649
Pubmed	Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.	KMT2B ARHGEF17 CIC	9.05e-04	104	63	3	9205841
Pubmed	Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	SHANK2 TTC28 CAMSAP2	9.05e-04	104	63	3	10470851
Pubmed	The nuclear interactome of DYRK1A reveals a functional role in DNA damage repair.	LRBA CDC27 CAMSAP2	9.57e-04	106	63	3	31024071
Pubmed	Human Immunodeficiency Virus Type 1 Vpr Mediates Degradation of APC1, a Scaffolding Component of the Anaphase-Promoting Complex/Cyclosome.	CCDC14 LRBA CDC27 CIC	9.87e-04	242	63	4	34011540
Pubmed	TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.	PHLDB1 FMR1 TTC28 KDM2B CIC EP300	1.04e-03	638	63	6	31182584
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	GRAMD1B MICAL1 PHLDB1 FMR1 SHANK2 CKAP5 SYN2 ARHGEF17 CAMSAP2	1.05e-03	1431	63	9	37142655
Pubmed	Large-scale cDNA transfection screening for genes related to cancer development and progression.	GAL3ST4 ADAMTSL4 PSRC1	1.18e-03	114	63	3	15498874
Pubmed	Expressed sequence tag analysis of human RPE/choroid for the NEIBank Project: over 6000 non-redundant transcripts, novel genes and splice variants.	EEF2K CAMSAP2 EP300	1.27e-03	117	63	3	12107410
Pubmed	Quantitative dissection and stoichiometry determination of the human SET1/MLL histone methyltransferase complexes.	KMT2B CDC27 ARHGEF17	1.34e-03	119	63	3	23508102
Pubmed	RNF43 inhibits WNT5A-driven signaling and suppresses melanoma invasion and resistance to the targeted therapy.	NUP107 TTC28 CKAP5 LRBA	1.34e-03	263	63	4	34702444
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	TAOK2 KMT2B SHANK2 CKAP5 KDM2B CRTC1 CDC27 CAMSAP2 CIC	1.44e-03	1497	63	9	31527615
Pubmed	SRC Homology 2 Domain Binding Sites in Insulin, IGF-1 and FGF receptor mediated signaling networks reveal an extensive potential interactome.	MAP4K1 IRS1	1.55e-03	32	63	2	22974441
Pubmed	Multiplexed barcoded CRISPR-Cas9 screening enabled by CombiGEM.	KDM2B EP300	1.64e-03	33	63	2	26864203
Pubmed	Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.	TAOK2 TTC28 CKAP5	1.72e-03	130	63	3	12421765
Pubmed	Gfi1b regulates the level of Wnt/β-catenin signaling in hematopoietic stem cells and megakaryocytes.	KDM2B EP300	1.75e-03	34	63	2	30894540
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	TAOK2 FMR1 SHANK2 HCN4 CKAP5 DNM3 CAMSAP2	1.75e-03	963	63	7	28671696
Pubmed	BioID-based intact cell interactome of the Kv1.3 potassium channel identifies a Kv1.3-STAT3-p53 cellular signaling pathway.	TBC1D8 TBC1D10B TTC28 CKAP5 LRBA CDC27	1.77e-03	708	63	6	39231216
Pubmed	The DNA sequence and biology of human chromosome 19.	TBXA2R KMT2B CRTC1 CIC	1.78e-03	284	63	4	15057824
Pubmed	Identification of 14-3-3epsilon substrates from embryonic murine brain.	SYN2 CRTC1 IRS1	1.80e-03	132	63	3	16944949
Interaction	PHF21A interactions	KMT2B NUP107 TTC28 TET1 CKAP5 KDM2B CRTC1 LRBA CIC	1.14e-06	343	63	9	int:PHF21A
Interaction	YWHAG interactions	TAOK2 TBC1D10B CRTC3 PHLDB1 RAPH1 TTC28 TET1 CKAP5 SYN2 CRTC1 IRS1 LRBA ARHGEF17 CAMSAP2 CIC	5.07e-06	1248	63	15	int:YWHAG
Interaction	KDM1A interactions	CCDC14 FMR1 KMT2B NUP107 RAPH1 TTC28 TET1 CKAP5 KDM2B CRTC1 LRBA CIC EP300	5.51e-06	941	63	13	int:KDM1A
Interaction	MAPRE3 interactions	TAOK2 ZNF526 TTC28 CKAP5 CDC27 CAMSAP2 PSRC1	7.40e-06	230	63	7	int:MAPRE3
Interaction	DYRK1A interactions	NUP107 CKAP5 DNM3 IRS1 LRBA CDC27 ARHGEF17 CAMSAP2 CIC EP300	7.59e-06	552	63	10	int:DYRK1A
Interaction	TOP3B interactions	TAOK2 ENGASE TLNRD1 PHLDB1 FMR1 KMT2B SHANK2 LMX1B KCNH2 MTG2 FRMD8 IRS1 LRBA ADAMTSL4 CIC EP300	8.13e-06	1470	63	16	int:TOP3B
Interaction	RCOR1 interactions	KMT2B NUP107 RAPH1 TTC28 TET1 CKAP5 KDM2B LRBA CIC	2.17e-05	494	63	9	int:RCOR1
Interaction	YWHAH interactions	TBC1D10B CRTC3 PHLDB1 TTC28 KCNH2 TET1 CKAP5 CRTC1 IRS1 LRBA ARHGEF17 CAMSAP2 CIC	2.96e-05	1102	63	13	int:YWHAH
Interaction	YWHAZ interactions	TBXA2R GRAMD1B CRTC3 PHLDB1 NUP107 RAPH1 TTC28 CKAP5 SYN2 CRTC1 IRS1 CAMSAP2 CIC EP300	4.45e-05	1319	63	14	int:YWHAZ
Interaction	RANGAP1 interactions	TAOK2 FMR1 NUP107 CKAP5 EEF2K CIC EP300	5.46e-05	314	63	7	int:RANGAP1
Interaction	YWHAE interactions	TAOK2 CRTC3 PHLDB1 TTC28 KCNH2 TET1 CKAP5 SYN2 CRTC1 IRS1 LRBA CAMSAP2 CIC	1.13e-04	1256	63	13	int:YWHAE
GeneFamily	Zinc fingers CXXC-type	KMT2B TET1 KDM2B	2.72e-06	12	43	3	136
GeneFamily	WD repeat domain containing\|GRAM domain containing\|BEACH domain containing	TBC1D8 GRAMD1B GRAMD1A	3.52e-06	13	43	3	1146
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	PHLDB1 RAPH1 DNM3 IRS1	1.43e-03	206	43	4	682
Coexpression	GSE19888_ADENOSINE_A3R_INH_VS_ACT_WITH_INHIBITOR_PRETREATMENT_IN_MAST_CELL_DN	SEC16B FNDC1 KCNH2 CKAP5 COL14A1 ARHGEF17	7.89e-06	200	62	6	M7323
ToppCell	LPS-IL1RA+antiTNF-Myeloid-Dendritic_cells-pDC\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	TBC1D8 GRAMD1B MICAL1 TBC1D10B MAP4K1 EMILIN2	7.08e-08	152	62	6	0c6dd41142e4ca1e54ca41e05e42ed29fbf0e570
ToppCell	LPS-antiTNF-Myeloid-Dendritic_cells-pDC\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	TBC1D8 GRAMD1B TBC1D10B MAP4K1 EMILIN2	1.02e-06	129	62	5	454bae525f6db3d0dd6347d2a2c3ea9dda9cd212
ToppCell	LPS-IL1RA-Myeloid-Dendritic_cells-pDC\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	TBC1D8 GRAMD1B TBC1D10B MAP4K1 EMILIN2	2.93e-06	160	62	5	dee756a2dc9725520d439e7273c489c2284015d8
ToppCell	renal_cortex_nuclei\|World / Celltypes from Cells and Nuclei per compartment and clinical group	GRAMD1B DENND5B SHANK2 TTC28 LRBA	7.14e-06	192	62	5	e8cc4d08fcfceeab75a02558817e4ccd7dbafe3a
ToppCell	facs-Trachea-18m-Mesenchymal-fibroblast-fibroblast_of_trachea-tracheal_fibroblast_l20-25\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	FNDC1 PHLDB1 EMILIN2 COL14A1 ADAMTSL4	7.50e-06	194	62	5	7b6ec45adb7ece3c8a7b78c5782413b5825effe2
ToppCell	Tracheal-10x3prime_v2-Epithelial-Epi_airway_neuro-secretory\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	SOWAHA LMX1B CKAP5 IRS1 INPP5J	8.08e-06	197	62	5	ff4df77117165b6b25315e29b0722cc136eba607
ToppCell	Tracheal-10x3prime_v2-Immune_Myeloid-Macrophage_other-Macro_AW_CX3CR1\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	DENND5B MICAL1 DNM3 GAL3ST4 INPP5J	8.49e-06	199	62	5	514dbf128b6832b1cbd65be023d4fe02400e8dec
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Fibroblasts-Monocytes-Macrophages\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	TBC1D8 NUP107 MAP4K1 EMILIN2	5.85e-05	151	62	4	f13a117ae26ae525da4f3e837d8f204d00dc6ee3
ToppCell	356C-Lymphocytic-CD4_T-cell-Treg_cell_4\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	TBC1D8 GRAMD1A DNM3 CAMSAP2	7.32e-05	160	62	4	c2b5fadb4bac17fafc08831f6d3f4ff96ada7e70
ToppCell	facs-Lung-EPCAM-3m-Endothelial-vein_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KMT2B NUP107 DNM3 RMND1	8.05e-05	164	62	4	1d0d88132baaa3154c3e6e4ef0aff795afab08a2
ToppCell	facs-Lung-EPCAM-3m-Endothelial-Vein_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KMT2B NUP107 DNM3 RMND1	8.05e-05	164	62	4	bd2e10b015d5e6a338675500ec5d81dc39583b3e
ToppCell	368C-Myeloid-Macrophage-FABP4+_Macrophage_2\|Macrophage / Donor, Lineage, Cell class and subclass (all cells)	TBXA2R KCNH2 DNM3 CHSY3	8.24e-05	165	62	4	3d2acdae0dd2b79a15f74158e8e566ce22b4218e
ToppCell	368C-Myeloid-Macrophage-FABP4+_Macrophage_2\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	TBXA2R KCNH2 DNM3 CHSY3	9.46e-05	171	62	4	e59afa0a773dca3b9c208d17510ea55703b42598
ToppCell	tumor_Lymph_Node_/_Brain-T/NK_cells-CD8+/CD4+_Mixed_Th\|T/NK_cells / Location, Cell class and cell subclass	MTG2 GAL3ST4 EEF2K CDC27	9.90e-05	173	62	4	42c911ed16fabdabef063830e8407192d8bde950
ToppCell	3'-Distal_airway-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophages-Alveolar_macrophages_L.1.0.3.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	EMILIN2 PDZD7 CAMSAP2 ADAMTSL4	1.06e-04	176	62	4	76fdf211bce101e83a27d822cb399487bd107027
ToppCell	LPS-IL1RA-Myeloid-Dendritic_cells\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	TBC1D8 GRAMD1B MAP4K1 EMILIN2	1.06e-04	176	62	4	f3bbe8c1a8d132705eac360cf531261271d84588
ToppCell	ASK428-Epithelial-Secretory\|Epithelial / Donor, Lineage and Cell class of Lung cells from Dropseq	TBC1D10B CYP24A1 EMILIN2 COL14A1	1.08e-04	177	62	4	66074a288501c136b4e83b883db5f0d8269ee326
ToppCell	5'-GW_trimst-2-SmallIntestine-Endothelial-blood_vessel_EC-arterial_capillary\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TBXA2R TLNRD1 PHLDB1 GRAMD1A	1.15e-04	180	62	4	755050226eeb1991ee7f0d15e39d0458f3e4a791
ToppCell	5'-Airway_Nasal-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell-Multiciliated_(nasal)-Multiciliated_(nasal)_L.0.3.1.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	TBC1D8 CYP24A1 DLEC1 CFAP157	1.15e-04	180	62	4	1f1af4474f3f0ac3c0d6b1a6c875c354d36d8eec
ToppCell	Children_(3_yrs)-Mesenchymal-pericyte_cell-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	PHLDB1 DCLK3 IRS1 ARHGEF17	1.18e-04	181	62	4	451b87ac95154bb80018b8dd245b4a6389d81411
ToppCell	E18.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-SCMF-SCMF_prolif\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FNDC1 CRTC1 IRS1 CIC	1.25e-04	184	62	4	a6dee97ee4ef9d89e11d17339e0dadaea1210ce5
ToppCell	normal_Lung-Myeloid_cells-Activated_DCs\|normal_Lung / Location, Cell class and cell subclass	TBC1D8 CCT8L2 GRAMD1A KDM2B	1.31e-04	186	62	4	0987c9a39503eb6c75a2bf4db98b2b2fd46956fb
ToppCell	pdx\|World / Sample and Cell Type and Tumor Cluster (all cells)	TBC1D8 DENND5B TTC28 KDM2B	1.31e-04	186	62	4	de8e538c8767d41b8a52f5e58ba1affd4e7244c4
ToppCell	pdx-Tumor_cells\|World / Sample and Cell Type and Tumor Cluster (all cells)	TBC1D8 DENND5B TTC28 KDM2B	1.31e-04	186	62	4	0b88a87158a9ca8de3bf40a4ff1687150707a5f0
ToppCell	normal_Lung-Myeloid_cells-Activated_DCs\|Myeloid_cells / Location, Cell class and cell subclass	TBC1D8 CCT8L2 GRAMD1A KDM2B	1.31e-04	186	62	4	00ad1239b952119b3fd2e6af8f034cba3488f9c1
ToppCell	P03-Endothelial-large_vessel_endothelial_cell-endothelial_cell_of_vein\|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	DENND5B TLNRD1 DNM3 COL14A1	1.36e-04	188	62	4	5eb107122064f0a99dfd445cc87d3766f7257216
ToppCell	facs-Trachea-3m-Mesenchymal-fibroblast-fibroblast_of_trachea-tracheal_fibroblast_l20-1\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	FNDC1 EMILIN2 COL14A1 ADAMTSL4	1.36e-04	188	62	4	aa516273cdde53c8c0295f06830972388f890c97
ToppCell	(2)_Fibroblasts-(20)_Fibro-1\|World / Cell class and subclass of bone marrow stroma cells in homeostatis	FNDC1 EMILIN2 COL14A1 ADAMTSL4	1.36e-04	188	62	4	409a7b69d02e87084ca955e3fe6c77230dee8861
ToppCell	droplet-Limb_Muscle-nan-21m-Mesenchymal-nan\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FNDC1 EMILIN2 COL14A1 ADAMTSL4	1.39e-04	189	62	4	0a8b827bba1efd885ad6c06929251c741dc3a541
ToppCell	P07-Endothelial-large_vessel_endothelial_cell-endothelial_cell_of_vein\|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	DENND5B TLNRD1 DNM3 COL14A1	1.42e-04	190	62	4	e1b721bb74561fe51c53328a0394c9954e489049
ToppCell	facs-Aorta-Heart-3m-Mesenchymal-fibroblast\|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FNDC1 SEMA3B EMILIN2 COL14A1	1.45e-04	191	62	4	9214655dca96d766737c9f30b624d7fe7050342e
ToppCell	facs-Trachea-3m-Mesenchymal-fibroblast-fibroblast_of_trachea-tracheal_fibroblast_l20-25\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	FNDC1 EMILIN2 COL14A1 ADAMTSL4	1.48e-04	192	62	4	30cefa0990ba1f379f350bfbf994a78db145075e
ToppCell	facs-Aorta-Heart-3m-Mesenchymal\|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FNDC1 SEMA3B EMILIN2 COL14A1	1.48e-04	192	62	4	0dc1f46e40346ed0b286e53b106a812441575100
ToppCell	Mesenchymal_cells-Endosteal_fibro.\|Mesenchymal_cells / Lineage and Cell class	FNDC1 EMILIN2 COL14A1 ADAMTSL4	1.54e-04	194	62	4	9a4b5de4d1d8a0aa76fed7b36548ea628f3009cc
ToppCell	Mesenchymal_cells-Endosteal_fibro.\|World / Lineage and Cell class	FNDC1 EMILIN2 COL14A1 ADAMTSL4	1.57e-04	195	62	4	d53974d1866e23c894ffd492ea11d20422919b11
ToppCell	facs-Trachea-24m-Mesenchymal-fibroblast-fibroblast_of_trachea-tracheal_fibroblast_l20-25\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	FNDC1 EMILIN2 COL14A1 ADAMTSL4	1.60e-04	196	62	4	ed6047b48b6a96baa6a90c7af784e7c34b32824d
ToppCell	facs-Aorta-Heart-3m-Mesenchymal-fibroblast_of_cardiac_tissue\|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FNDC1 SEMA3B EMILIN2 COL14A1	1.60e-04	196	62	4	2029f58ce6a7b8c35d3a7496c3341391990909ce
ToppCell	Tracheal-10x3prime_v2-Epithelial-Epi_airway_neuro-secretory-Ionocyte_n_Brush\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	SOWAHA LMX1B IRS1 INPP5J	1.66e-04	198	62	4	62059185afdf66126a6fbc899ce611c47e7a0feb
ToppCell	background-Hepatic_Stellate_cells\|World / Sample and Cell Type and Tumor Cluster (all cells)	TBXA2R FNDC1 COL14A1 CHSY3	1.66e-04	198	62	4	79f32f965aed6a10c5cb803173e3db7b32e07a91
ToppCell	LPS_only-Hematopoietic_Myeloid-Dendritic_cells-pDC\|LPS_only / Treatment groups by lineage, cell group, cell type	TBC1D8 GRAMD1B MAP4K1 EEF2K	1.66e-04	198	62	4	d205dfcfe1f20e1e21bf84759e723d9e6e610a5c
ToppCell	mLN-(5)_Dendritic_cell-(53)_Lymphoid_DC\|mLN / shred on region, Cell_type, and subtype	TBC1D8 RAPH1 ADAMTSL4 INPP5J	1.66e-04	198	62	4	da84c76afe835aeee39da04b63c03549218b5d91
ToppCell	mLN-Dendritic_cell-Lymphoid_DC\|mLN / Region, Cell class and subclass	TBC1D8 RAPH1 ADAMTSL4 INPP5J	1.66e-04	198	62	4	3965a9f1e8a51a196e5349aaca5fa5ed1cd8ee92
ToppCell	Bronchial-10x5prime-Stromal-Peri/Epineurial_-NAF_epineurial\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	TET1 PDZD7 IRS1 CAMSAP2	1.69e-04	199	62	4	a13f4b8a039304e685464cc8879659824cad5a3e
ToppCell	LPS_IL1RA-Hematopoietic_Myeloid-Dendritic_cells-pDC\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	TBC1D8 GRAMD1B MICAL1 MAP4K1	1.69e-04	199	62	4	f197ab861767ee06aa47b86c537fb3d8c2b2bc3e
ToppCell	Tracheal-10x5prime-Stromal-Schwann-Schwann_Myelinating\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	MICAL1 SOWAHA SEMA3B DCLK3	1.69e-04	199	62	4	2b567b6fd8addf059bbf2b72c55a7647aefdc595
ToppCell	Control_saline-Mesenchymal_myocytic-Myofibroblastic-Myofibroblast\|Control_saline / Treatment groups by lineage, cell group, cell type	FNDC1 KCNH2 DCLK3 IRS1	1.73e-04	200	62	4	c5e051f1aac8dda376c342a9932785a23450e073
ToppCell	TCGA-Bile_Duct-Primary_Tumor-Cholangiocarcinoma-Intrahepatic\|TCGA-Bile_Duct / Sample_Type by Project: Shred V9	TAOK2 TBC1D8 CAMSAP2 CIC	1.73e-04	200	62	4	1fa8422fd820d21e285a7e7c4c6fbd8b7277d2af
ToppCell	LPS_only-Mesenchymal_myocytic-Myofibroblastic-Myofibroblast\|LPS_only / Treatment groups by lineage, cell group, cell type	FNDC1 KCNH2 DCLK3 IRS1	1.73e-04	200	62	4	593bf6a7c557437db9a9249a5058a46014179ef6
ToppCell	LPS_only-Mesenchymal_myocytic-Myofibroblastic\|LPS_only / Treatment groups by lineage, cell group, cell type	FNDC1 KCNH2 DCLK3 IRS1	1.73e-04	200	62	4	02cae2c296a13ad4cbb53bca7a86d64629d67d66
ToppCell	LPS_IL1RA_TNF-Mesenchymal_myocytic-Myofibroblastic-Myofibroblast\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	FNDC1 KCNH2 DCLK3 IRS1	1.73e-04	200	62	4	dcdaec3ca3a3024dc1b8788c417003f84c2bffdc
Computational	Genes upregulated in subsets of cells of a given type within various tumors	FNDC1 EMILIN2 COL14A1 ADAMTSL4	1.01e-05	48	31	4	GAVISH_3CA_METAPROGRAM_FIBROBLASTS_PI16_POS
Drug	trifluoperazine dihydrochloride; Up 200; 10uM; MCF7; HT_HG-U133A_EA	ENGASE SHANK2 KCNH2 CYP24A1 SEMA3B ARHGEF17	1.05e-05	186	61	6	1004_UP
Drug	Rolitetracycline [751-97-3]; Up 200; 7.6uM; MCF7; HT_HG-U133A	TBXA2R SHANK2 KCNH2 SYN2 CRTC1 ARHGEF17	1.41e-05	196	61	6	3369_UP
Drug	Alclometasone dipropionate [667634-13-2]; Up 200; 7.6uM; MCF7; HT_HG-U133A	GRAMD1B DENND5B PHLDB1 KCNH2 DNM3 CRTC1	1.45e-05	197	61	6	6094_UP
Drug	Chlortetracycline hydrochloride [64-72-2]; Up 200; 7.8uM; MCF7; HT_HG-U133A	TAOK2 KMT2B SHANK2 TTC28 KCNH2 INPP5J	1.50e-05	198	61	6	1541_UP
Drug	Glimepiride [93479-97-1]; Up 200; 8.2uM; HL60; HT_HG-U133A	PHLDB1 MAP4K1 SYN2 GAL3ST4 CRTC1 ADAMTSL4	1.50e-05	198	61	6	2154_UP
Drug	Phthalylsulfathiazole [85-73-4]; Up 200; 10uM; MCF7; HT_HG-U133A	TBXA2R PHLDB1 PRDM10 SHANK2 MAP4K1 ARHGEF17	1.50e-05	198	61	6	5614_UP
Drug	Protoveratrine A [143-57-7]; Up 200; 5uM; PC3; HT_HG-U133A	PHLDB1 KMT2B HCN4 MAP4K1 COL14A1 CIC	1.54e-05	199	61	6	6618_UP
Drug	zatebradine	HCN4 KCNH2	2.11e-05	3	61	2	ctd:C043636
Drug	gamma-pyrone	TBXA2R KCNH2	1.05e-04	6	61	2	CID000007968
Drug	Aprindine	HCN4 KCNH2	1.05e-04	6	61	2	ctd:D001073
Drug	cifenline	HCN4 KCNH2	1.47e-04	7	61	2	ctd:C032151
Drug	Tiabendazole [148-79-8]; Down 200; 19.8uM; MCF7; HT_HG-U133A	TAOK2 KMT2B TTC28 CIC EP300	1.72e-04	194	61	5	2840_DN
Drug	Iopanoic acid [96-83-3]; Down 200; 7uM; MCF7; HT_HG-U133A	TAOK2 PHLDB1 KMT2B KCNH2 SEMA3B	1.72e-04	194	61	5	3527_DN
Drug	Nefopam hydrochloride [23327-57-3]; Down 200; 13.8uM; MCF7; HT_HG-U133A	PHLDB1 TTC28 KCNH2 SYN2 CRTC1	1.77e-04	195	61	5	2317_DN
Drug	Melatonin [73-31-4]; Up 200; 17.2uM; PC3; HT_HG-U133A	TAOK2 TBXA2R PHLDB1 SYN2 CRTC1	1.77e-04	195	61	5	6293_UP
Drug	Parbendazole [14255-87-9]; Down 200; 16.2uM; MCF7; HT_HG-U133A	TAOK2 ENGASE TTC28 KCNH2 ARHGEF17	1.81e-04	196	61	5	3881_DN
Drug	N-Acetyl-DL-homocysteine Thiolactone [1195-16-0]; Up 200; 25.2uM; MCF7; HT_HG-U133A	DENND5B MICAL1 HCN4 DNM3 INPP5J	1.81e-04	196	61	5	3930_UP
Drug	Demeclocycline hydrochloride [64-73-3]; Up 200; 8uM; MCF7; HT_HG-U133A	TAOK2 GRAMD1B PRDM10 SHANK2 SYN2	1.81e-04	196	61	5	3604_UP
Drug	Iohexol [66108-95-0]; Up 200; 4.8uM; MCF7; HT_HG-U133A	HCN4 KCNH2 SEMA3B SYN2 ARHGEF17	1.81e-04	196	61	5	5704_UP
Drug	Benzocaine [94-09-7]; Up 200; 24.2uM; MCF7; HT_HG-U133A	TBXA2R LMX1B CYP24A1 CRTC1 ARHGEF17	1.81e-04	196	61	5	4808_UP
Drug	Clofilium tosylate [92953-10-1]; Down 200; 7.8uM; MCF7; HT_HG-U133A	TAOK2 ENGASE MICAL1 KCNH2 CRTC1	1.81e-04	196	61	5	3187_DN
Drug	Bemegride [64-65-3]; Up 200; 25.8uM; MCF7; HT_HG-U133A	TAOK2 TTC28 KCNH2 SEMA3B COL14A1	1.81e-04	196	61	5	5014_UP
Drug	0173570-0000 [211245-44-2]; Up 200; 1uM; MCF7; HT_HG-U133A	TAOK2 PHLDB1 CYP24A1 SEMA3B SYN2	1.85e-04	197	61	5	4715_UP
Drug	Fenoprofen calcium salt dihydrate [53746-45-5]; Up 200; 7.2uM; MCF7; HT_HG-U133A	MICAL1 PHLDB1 PRDM10 SHANK2 ARHGEF17	1.85e-04	197	61	5	3412_UP
Drug	Dexamethasone acetate [1177-87-3]; Up 200; 9.2uM; MCF7; HT_HG-U133A	TAOK2 TBXA2R SHANK2 TTC28 CIC	1.85e-04	197	61	5	6271_UP
Drug	LY 294002; Down 200; 0.1uM; MCF7; HT_HG-U133A	TAOK2 MICAL1 PHLDB1 KCNH2 ARHGEF17	1.85e-04	197	61	5	5576_DN
Drug	Carbinoxamine maleate salt [3505-38-2]; Up 200; 9.8uM; MCF7; HT_HG-U133A	PHLDB1 KMT2B COL14A1 ARHGEF17 CIC	1.85e-04	197	61	5	3466_UP
Drug	Lidoflazine [3416-26-0]; Up 200; 8.2uM; MCF7; HT_HG-U133A	TTC28 HCN4 SEMA3B SYN2 CRTC1	1.85e-04	197	61	5	3201_UP
Drug	Flunixin meglumine [42461-84-7]; Up 200; 8.2uM; MCF7; HT_HG-U133A	TAOK2 MICAL1 PHLDB1 LMX1B ARHGEF17	1.85e-04	197	61	5	3411_UP
Drug	Oxolinic acid [14698-29-4]; Up 200; 15.4uM; MCF7; HT_HG-U133A	TBXA2R MICAL1 PHLDB1 KCNH2 SEMA3B	1.85e-04	197	61	5	5519_UP
Drug	Ifosfamide [3778-73-2]; Down 200; 15.4uM; PC3; HT_HG-U133A	TBXA2R TTC28 SYN2 CRTC1 ARHGEF17	1.85e-04	197	61	5	5805_DN
Drug	Lomefloxacin hydrochloride [98079-52-8]; Down 200; 10.4uM; MCF7; HT_HG-U133A	TAOK2 MICAL1 SHANK2 CRTC1 INPP5J	1.85e-04	197	61	5	4745_DN
Drug	alpha-Santonin [481-06-1]; Down 200; 16.2uM; MCF7; HT_HG-U133A	TAOK2 CRTC1 ARHGEF17 CIC INPP5J	1.85e-04	197	61	5	3877_DN
Drug	Iopamidol [60166-93-0]; Up 200; 5.2uM; HL60; HT_HG-U133A	TAOK2 TBXA2R PHLDB1 SHANK2 COL14A1	1.90e-04	198	61	5	2732_UP
Drug	Etodolac [41340-25-4]; Up 200; 14uM; MCF7; HT_HG-U133A	TBXA2R SHANK2 TTC28 COL14A1 INPP5J	1.90e-04	198	61	5	7006_UP
Drug	Carbetapentane citrate [23142-01-0]; Up 200; 7.6uM; MCF7; HT_HG-U133A	TAOK2 SHANK2 MAP4K1 SEMA3B ARHGEF17	1.90e-04	198	61	5	2623_UP
Drug	Bupropion hydrochloride [31677-93-7]; Up 200; 14.4uM; PC3; HT_HG-U133A	TAOK2 TBXA2R SHANK2 HCN4 LMX1B	1.90e-04	198	61	5	5782_UP
Drug	Dipyrone [5907-38-0]; Up 200; 12uM; MCF7; HT_HG-U133A	TBXA2R MICAL1 SHANK2 COL14A1 INPP5J	1.90e-04	198	61	5	3929_UP
Drug	Riboflavine [83-88-5]; Up 200; 10.6uM; MCF7; HT_HG-U133A	TAOK2 TBXA2R DENND5B ENGASE CRTC1	1.90e-04	198	61	5	2760_UP
Drug	N-Acetyl-DL-homocysteine Thiolactone [1195-16-0]; Down 200; 25.2uM; MCF7; HT_HG-U133A	PHLDB1 SHANK2 LMX1B CRTC1 CIC	1.90e-04	198	61	5	6031_DN
Drug	Tropicamide [1508-75-4]; Up 200; 14uM; PC3; HT_HG-U133A	KMT2B HCN4 GAL3ST4 CRTC1 ARHGEF17	1.90e-04	198	61	5	4280_UP
Drug	Betahistine mesylate [54856-23-4]; Up 200; 17.2uM; MCF7; HT_HG-U133A	SHANK2 CRTC1 ARHGEF17 CIC INPP5J	1.90e-04	198	61	5	4956_UP
Drug	Tolazamide [1156-19-0]; Down 200; 12.8uM; MCF7; HT_HG-U133A	ENGASE SHANK2 CRTC1 ARHGEF17 CIC	1.90e-04	198	61	5	2842_DN
Drug	Proparacaine hydrochloride [5875-06-9]; Up 200; 12uM; HL60; HT_HG-U133A	SHANK2 SYN2 GAL3ST4 CRTC1 INPP5J	1.94e-04	199	61	5	3113_UP
Drug	Sulfadiazine [68-35-9]; Up 200; 16uM; MCF7; HT_HG-U133A	MICAL1 TTC28 KCNH2 COL14A1 INPP5J	1.94e-04	199	61	5	5523_UP
Drug	Bemegride [64-65-3]; Up 200; 25.8uM; PC3; HT_HG-U133A	TAOK2 PHLDB1 COL14A1 ARHGEF17 CIC	1.94e-04	199	61	5	6668_UP
Drug	Cholecalciferol [67-97-0]; Down 200; 10.4uM; MCF7; HT_HG-U133A	ENGASE SHANK2 TTC28 CRTC1 CIC	1.94e-04	199	61	5	5002_DN
Drug	Epirizole [18694-40-1]; Up 200; 17uM; MCF7; HT_HG-U133A	TBXA2R MICAL1 PHLDB1 TTC28 KCNH2	1.94e-04	199	61	5	5995_UP
Drug	Skimmianine [83-95-4]; Up 200; 15.4uM; PC3; HT_HG-U133A	HCN4 SYN2 COL14A1 DLEC1 CIC	1.94e-04	199	61	5	5766_UP
Drug	Delcorine; Down 200; 8.4uM; MCF7; HT_HG-U133A	TAOK2 LMX1B KCNH2 DNM3 INPP5J	1.94e-04	199	61	5	6033_DN
Drug	(-) -Levobunolol hydrochloride [27912-14-7]; Up 200; 12.2uM; MCF7; HT_HG-U133A	TBXA2R DENND5B DNM3 SYN2 ARHGEF17	1.99e-04	200	61	5	3354_UP
Drug	Clomipramine hydrochloride [17321-77-6]; Up 200; 11.4uM; MCF7; HT_HG-U133A	TBXA2R SHANK2 HCN4 SEMA3B GAL3ST4	1.99e-04	200	61	5	3182_UP
Drug	Disopyramide	HCN4 KCNH2	2.51e-04	9	61	2	ctd:D004206
Drug	Mexiletine	HCN4 KCNH2	2.51e-04	9	61	2	ctd:D008801
Disease	Gonadal Dysgenesis	FMR1 NUP107	4.20e-06	2	61	2	C0018051
Disease	autism spectrum disorder (implicated_via_orthology)	TAOK2 FMR1 SHANK2 SYN2 LRBA	1.60e-05	152	61	5	DOID:0060041 (implicated_via_orthology)
Disease	waist-hip ratio	TAOK2 SEC16B TTC28 HCN4 SEMA3B EMILIN2 DNM3 COL14A1 CRTC1 DLEC1	1.93e-04	1226	61	10	EFO_0004343
Disease	Mental Retardation, Psychosocial	ZNF526 FMR1 SHANK2 CIC	2.00e-04	139	61	4	C0025363
Disease	Profound Mental Retardation	ZNF526 FMR1 SHANK2 CIC	2.00e-04	139	61	4	C0020796
Disease	Mental deficiency	ZNF526 FMR1 SHANK2 CIC	2.00e-04	139	61	4	C0917816
Disease	Malignant neoplasm of breast	MICAL1 RAPH1 CYP24A1 DLEC1 LRBA RMND1 CDC27 CIC EP300	3.43e-04	1074	61	9	C0006142
Disease	Lipidemias	LMX1B IRS1	5.60e-04	17	61	2	C1706412
Disease	Hyperlipidemia	LMX1B IRS1	5.60e-04	17	61	2	C0020473
Disease	cumulative dose response to bevacizumab	GRAMD1B CRTC1	7.03e-04	19	61	2	EFO_0005944
Disease	Kidney Failure	LMX1B CYP24A1	9.46e-04	22	61	2	C0035078
Disease	Adenocarcinoma of large intestine	DCLK3 EEF2K EP300	1.05e-03	96	61	3	C1319315
Disease	Brugada Syndrome (disorder)	HCN4 KCNH2	1.13e-03	24	61	2	C1142166
Disease	central nervous system cancer, glioma	PHLDB1 CRTC1	1.65e-03	29	61	2	EFO_0000326, EFO_0005543

Protein segments in the cluster

Peptide	Gene	Start	Entry
LQNLLRTLRSPSSPL	EP300	2051	Q09472
NQTLSTRCPPQLRPS	ADAMTSL4	1001	Q6UY14
SPLSKRLSPQPQIRA	CCDC14	791	Q49A88
RPSIQLPRTGSLLPQ	CFAP157	436	Q5JU67
RQPQTLASSPRSRPG	ASTL	361	Q6HA08
SPSLRKRLQLLPPSR	GRAMD1A	16	Q96CP6
SPILRKRSRSPTPQN	GRAMD1B	21	Q3KR37
PPTRPKRNDSTRLTQ	RAPH1	1121	Q70E73
TPRNQVIPRTPSSFR	NUP107	46	P57740
QPRPLRSLSPSVRQL	ARHGEF17	71	Q96PE2
PSSSLAPVQRPKLRR	FRMD8	391	Q9BZ67
SLLNIPLSSPGRRPR	KCNH2	1021	Q12809
SPRNPTQELRRPSKS	DCLK3	206	Q9C098
TQRRPTLSAPLARPT	DNM3	776	Q9UQ16
LLALSRPRPPITRSQ	PDZD7	421	Q9H5P4
RPRPPITRSQSYLTL	PDZD7	426	Q9H5P4
LPQTRRISLASPRQL	LRBA	2191	P50851
PDPSQPTRRQIRLSS	MICAL1	796	Q8TDZ2
RSQAQTPPRSVPRLR	HRES1	26	P13985
SRRPLLLRAPQFTPS	KMT2B	641	Q9UMN6
PNRPVLTRARASLPL	PRDM10	196	Q9NQV6
LAPQPSTSNSQRLPR	PSRC1	251	Q6PGN9
NPPPSQVGLTRRSRT	IRS1	291	P35568
RRLPGLQLRQPSAPS	GAL3ST4	41	Q96RP7
LQLRQPSAPSLRPAL	GAL3ST4	46	Q96RP7
QDPSRRSIRLRPLPS	HCN4	41	Q9Y3Q4
LPTSAPRPTRFLRSQ	CKAP5	221	Q14008
LRQIGASSRPPPNRT	FMR1	441	Q06787
QLGPSLRSPPRVISR	KDM2B	1011	Q8NHM5
QQLRSPRQPPRLVTS	CYP24A1	16	Q07973
RRQQASPTLSPLSPI	CRTC1	321	Q6UUV9
TTNLSGPSRRRQPPV	CRTC3	376	Q6UUV7
TTLALSPPRNLRISN	COL14A1	531	Q05707
PRLSLTQAGRPRPTS	FNDC1	1031	Q4ZHG4
RTPPQQKSPTTARRL	DENND5B	1061	Q6ZUT9
QVRTLSGSRPPLLRP	EEF2K	361	O00418
LACRQPPLSSQRPRT	ENGASE	111	Q8NFI3
VKTLRPTPARPRNSL	EMILIN2	126	Q9BXX0
EPQLLRLRPSSLRTQ	DLEC1	76	Q9Y238
TITSPPNALPRRSSR	CDC27	366	P30260
SLPRLRRFSPSQVPI	CAMSAP2	1011	Q08AD1
ARLQPPRDLRSSSPR	MAP4K1	356	Q92918
QLLSRTPALSPQRPL	SYN2	416	Q92777
SRTRQPSRTNLPVLS	RMND1	151	Q9NWS8
PTRIPRLLPRSQRQL	TAOK2	1191	Q9UL54
RLLPRSQRQLGPPAS	TAOK2	1196	Q9UL54
LPQRLALNPRESPRS	CCT8L1P	11	A6NM43
LPQRLALNPRESPRS	CCT8L2	11	Q96SF2
PSRLLPQRASPRLLS	MTG2	31	Q9H4K7
RPPNTLAAPRVLLRS	SHANK2	406	Q9UPX8
LRSTSLSRRLSQPPL	TET1	106	Q8NFU7
PPLLPTRASRSQRAA	CIC	416	Q96RK0
QPPRQSLSSILRTAL	CHSY3	481	Q70JA7
ALLRSQPLRSQRSVP	C11orf94	26	C9JXX5
RSPSPQSRRLSRVAP	INPP5J	911	Q15735
LRQRLRSPTAPFTSP	PEX11G	151	Q96HA9
EPSPRSSPLLLRRLS	SOWAHA	246	Q2M3V2
RPQPALQSLPLESRR	SEMA3B	711	Q13214
SQSPLRNPLLSTSRP	TBC1D8	936	O95759
SQALRERSSPRTLPP	TLNRD1	341	Q9H1K6
RRRQQPPLGPSSSLL	TBC1D10B	646	Q4KMP7
PPTASQTRTLPRASR	nan	11	A8MUU9
SPSLSRRALSPLPTR	PHLDB1	461	Q86UU1
PQLPTATSLNRPNRL	SEC16B	1036	Q96JE7
LQRSTLPRSQLPPQT	TTC28	2031	Q96AY4
ARARTLTLQPPRSPS	ZNF526	596	Q8TF50
NSRAPPRLTVVSPNR	TAPR1	156	Q14CZ0
PRLSTRPRSLSLQPQ	TBXA2R	321	P21731
PRRPKRPRTILTTQQ	LMX1B	216	O60663