Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	selenide, water dikinase activity	SEPHS2 SEPHS1	5.99e-05	2	155	2	GO:0004756
GeneOntologyMolecularFunction	phosphotransferase activity, paired acceptors	SEPHS2 SEPHS1	5.99e-05	2	155	2	GO:0016781
GeneOntologyBiologicalProcess	columnar/cuboidal epithelial cell differentiation	RARA RARB GCM2 RFX6 WNT4 NFIB NR5A2 KCNMA1 DMBT1	3.62e-06	164	152	9	GO:0002065
GeneOntologyBiologicalProcess	glandular epithelial cell differentiation	RARA RARB GCM2 RFX6 WNT4 NFIB NR5A2	4.96e-06	91	152	7	GO:0002067
GeneOntologyBiologicalProcess	regulation of cell cycle	ANKRD31 RARA CDK15 VPS4B DUSP3 CDKL3 CUL9 AMBRA1 WNT4 ACVR1 WNK1 TRRAP KANK2 BIRC6 ADARB1 RFWD3 STAT5A STAT5B BAP1 HPGD TAF1 RAB11FIP4 DOT1L PLK3	1.61e-05	1256	152	24	GO:0051726
GeneOntologyBiologicalProcess	selenocysteine biosynthetic process	SEPHS2 SEPHS1	5.40e-05	2	152	2	GO:0016260
Domain	TFIID_sub1_DUF3591	TAF1 TAF1L	6.49e-05	2	151	2	IPR022591
Domain	TBP-binding	TAF1 TAF1L	6.49e-05	2	151	2	PF09247
Domain	DUF3591	TAF1 TAF1L	6.49e-05	2	151	2	PF12157
Domain	SPS/SelD	SEPHS2 SEPHS1	6.49e-05	2	151	2	IPR004536
Domain	TAF_II_230-bd	TAF1 TAF1L	6.49e-05	2	151	2	IPR009067
Domain	-	TAF1 TAF1L	6.49e-05	2	151	2	1.10.1100.10
Domain	TAF1_animal	TAF1 TAF1L	6.49e-05	2	151	2	IPR011177
Domain	-	SEPHS2 SEPHS1	1.94e-04	3	151	2	3.90.650.10
Domain	Peripla_BP_I	GUCY2F TAS1R1 GRIN3A GRIN3B	2.71e-04	39	151	4	IPR028082
Domain	Retinoic_acid_rcpt	RARA RARB	3.85e-04	4	151	2	IPR003078
Domain	KN_motif	KANK2 KANK1	3.85e-04	4	151	2	IPR021939
Domain	Gal_mutarotase_N	GAA MGAM2	3.85e-04	4	151	2	IPR031727
Domain	-	SEPHS2 SEPHS1	3.85e-04	4	151	2	3.30.1330.10
Domain	AIRS_C	SEPHS2 SEPHS1	3.85e-04	4	151	2	PF02769
Domain	AIRS	SEPHS2 SEPHS1	3.85e-04	4	151	2	PF00586
Domain	PurM-like_N	SEPHS2 SEPHS1	3.85e-04	4	151	2	IPR016188
Domain	NtCtMGAM_N	GAA MGAM2	3.85e-04	4	151	2	PF16863
Domain	AIR_synth_C_dom	SEPHS2 SEPHS1	3.85e-04	4	151	2	IPR010918
Domain	KN_motif	KANK2 KANK1	3.85e-04	4	151	2	PF12075
Domain	Rho_GTPase_activation_prot	ARHGAP30 ARHGAP11A ARHGAP31 PLXNA1 ARHGAP33	7.38e-04	88	151	5	IPR008936
Domain	Glyco_hydro_31_AS	GAA MGAM2	9.53e-04	6	151	2	IPR030458
Domain	STAT_TF_DNA-bd_sub	STAT5A STAT5B	1.33e-03	7	151	2	IPR012345
Domain	STAT	STAT5A STAT5B	1.33e-03	7	151	2	IPR001217
Domain	Glyco_hydro_31	GAA MGAM2	1.33e-03	7	151	2	IPR000322
Domain	TFS2M	TCEA2 DIDO1	1.33e-03	7	151	2	SM00510
Domain	STAT_int	STAT5A STAT5B	1.33e-03	7	151	2	SM00964
Domain	STAT_TF_DNA-bd	STAT5A STAT5B	1.33e-03	7	151	2	IPR013801
Domain	STAT_bind	STAT5A STAT5B	1.33e-03	7	151	2	PF02864
Domain	STAT_int	STAT5A STAT5B	1.33e-03	7	151	2	PF02865
Domain	Glyco_hydro_31	GAA MGAM2	1.33e-03	7	151	2	PF01055
Domain	-	STAT5A STAT5B	1.33e-03	7	151	2	1.10.532.10
Domain	STAT_alpha	STAT5A STAT5B	1.33e-03	7	151	2	PF01017
Domain	-	STAT5A STAT5B	1.33e-03	7	151	2	1.20.1050.20
Domain	STAT_TF_prot_interaction	STAT5A STAT5B	1.33e-03	7	151	2	IPR013799
Domain	STAT_TF_coiled-coil	STAT5A STAT5B	1.33e-03	7	151	2	IPR015988
Domain	-	STAT5A STAT5B	1.33e-03	7	151	2	2.60.40.630
Domain	GLYCOSYL_HYDROL_F31_1	GAA MGAM2	1.33e-03	7	151	2	PS00129
Domain	TFIIS_M	TCEA2 DIDO1	1.33e-03	7	151	2	PF07500
Domain	RhoGAP	ARHGAP30 ARHGAP11A ARHGAP31 ARHGAP33	1.59e-03	62	151	4	SM00324
Domain	RhoGAP	ARHGAP30 ARHGAP11A ARHGAP31 ARHGAP33	1.69e-03	63	151	4	PF00620
Domain	TFIIS_cen_dom	TCEA2 DIDO1	1.76e-03	8	151	2	IPR003618
Domain	STAT_TF_alpha	STAT5A STAT5B	1.76e-03	8	151	2	IPR013800
Domain	-	TCEA2 DIDO1	1.76e-03	8	151	2	1.10.472.30
Domain	Trefoil	GAA MGAM2	1.76e-03	8	151	2	PF00088
Domain	TFIIS_CENTRAL	TCEA2 DIDO1	1.76e-03	8	151	2	PS51321
Domain	RhoGAP_dom	ARHGAP30 ARHGAP11A ARHGAP31 ARHGAP33	1.79e-03	64	151	4	IPR000198
Domain	RHOGAP	ARHGAP30 ARHGAP11A ARHGAP31 ARHGAP33	1.79e-03	64	151	4	PS50238
Domain	-	ARHGAP30 ARHGAP11A ARHGAP31 ARHGAP33	1.79e-03	64	151	4	1.10.555.10
Domain	Ank_2	ANKRD31 ANKRD50 KANK2 KANK1 ANKDD1B PLA2G6 TANC1	1.85e-03	215	151	7	PF12796
Domain	P_TREFOIL_2	GAA MGAM2	2.25e-03	9	151	2	PS51448
Domain	PD	GAA MGAM2	2.25e-03	9	151	2	SM00018
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	SEMA4F FRAS1 LRRC24 LAMA5 CUL9 AMBRA1 HUWE1 WNK1 TRRAP BIRC6 BAP1 SEPHS2 SLC16A5 SEC16A PLA2G6 POLL TANC1 DOT1L PLK3 PLXNA1 ARHGAP33 HTT	6.73e-09	1105	158	22	35748872
Pubmed	Coregulation of genetic programs by the transcription factors NFIB and STAT5.	STAT5A STAT5B NFIB	9.20e-08	3	158	3	24678731
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	LMF1 PLCXD1 GPATCH2 RTN3 WNT4 HUWE1 TRRAP ADARB1 SLC25A37 DNAH14 STAT5B INTS6 SYNJ2 NFIB SPACA6 KCNMA1 PLA2G6 TANC1 KAT6B PRDM15 GOLGB1 HTT	1.15e-06	1489	158	22	28611215
Pubmed	An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.	SEMA4F LMF1 VPS4B SMPD4 HUWE1 WNK1 KANK2 BIRC6 KANK1 SYNJ2 AMOTL1 YLPM1 SEC16A TANC1 R3HDM1	1.42e-06	733	158	15	34672954
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	LAMA5 AMBRA1 SMPD4 DIDO1 ANKRD50 ARHGAP11A HEPH BAP1 TUBGCP6 SYNJ2 ARHGAP31 KAT6B	5.99e-06	529	158	12	14621295
Pubmed	Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.	DIDO1 HUWE1 WNK1 SYNJ2 SEC16A KAT6B	8.40e-06	104	158	6	9205841
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	PLCXD1 GPATCH2 CUL9 AMBRA1 GIGYF1 TRRAP KANK2 TUBGCP6 DAP3 INTS6 TRAFD1 SUPT16H SEC16A TANC1 TAF1 KAT6B ARHGAP33	1.41e-05	1116	158	17	31753913
Pubmed	Whole exome sequencing identifies novel recurrently mutated genes in patients with splenic marginal zone lymphoma.	TRRAP AMOTL1 USH2A	1.48e-05	11	158	3	24349473
Pubmed	Close linkage of retinoic acid receptor genes with homeobox- and keratin-encoding genes on paralogous segments of mouse chromosomes 11 and 15.	RARA RARB WNT1	1.96e-05	12	158	3	1377062
Pubmed	Mapping of the mouse Rar loci encoding retinoic acid receptors RAR alpha, RAR beta and RAR gamma.	RARA RARB WNT1	1.96e-05	12	158	3	8251184
Pubmed	Definitive evidence using enucleated cytoplasts for a nongenomic basis for the cystic change in endoplasmic reticulum structure caused by STAT5a/b siRNAs.	STAT5A STAT5B	2.05e-05	2	158	2	23151802
Pubmed	Signal transducer and activator of transcription 5 (STAT5) paralog dose governs T cell effector and regulatory functions.	STAT5A STAT5B	2.05e-05	2	158	2	26999798
Pubmed	All-trans retinoic acid and arsenic trioxide resistance of acute promyelocytic leukemia with the variant STAT5B-RARA fusion gene.	RARA STAT5B	2.05e-05	2	158	2	23271512
Pubmed	Recurrent RARB Translocations in Acute Promyelocytic Leukemia Lacking RARA Translocation.	RARA RARB	2.05e-05	2	158	2	29921692
Pubmed	A Mouse Model to Assess STAT3 and STAT5A/B Combined Inhibition in Health and Disease Conditions.	STAT5A STAT5B	2.05e-05	2	158	2	31443474
Pubmed	Interleukin-2 family cytokines stimulate phosphorylation of the Pro-Ser-Pro motif of Stat5 transcription factors in human T cells: resistance to suppression of multiple serine kinase pathways.	STAT5A STAT5B	2.05e-05	2	158	2	12377952
Pubmed	A novel Ncr1-Cre mouse reveals the essential role of STAT5 for NK-cell survival and development.	STAT5A STAT5B	2.05e-05	2	158	2	21127177
Pubmed	The gammac-cytokine regulated transcription factor, STAT5, increases HIV-1 production in primary CD4 T cells.	STAT5A STAT5B	2.05e-05	2	158	2	16289657
Pubmed	Inhibition of Stat5a/b Enhances Proteasomal Degradation of Androgen Receptor Liganded by Antiandrogens in Prostate Cancer.	STAT5A STAT5B	2.05e-05	2	158	2	25552366
Pubmed	Deletion of STAT5a/b in vascular smooth muscle abrogates the male bias in hypoxic pulmonary hypertension in mice: implications in the human disease.	STAT5A STAT5B	2.05e-05	2	158	2	25470773
Pubmed	Constitutively active Stat5A and Stat5B promote adipogenesis.	STAT5A STAT5B	2.05e-05	2	158	2	21431790
Pubmed	Stat5 Is Required for CD103+ Dendritic Cell and Alveolar Macrophage Development and Protection from Lung Injury.	STAT5A STAT5B	2.05e-05	2	158	2	28500076
Pubmed	STAT5 isoforms regulate colorectal cancer cell apoptosis via reduction of mitochondrial membrane potential and generation of reactive oxygen species.	STAT5A STAT5B	2.05e-05	2	158	2	21826656
Pubmed	Retinoic acid receptors in normal growth and development.	RARA RARB	2.05e-05	2	158	2	1330302
Pubmed	Interleukin-3, granulocyte-macrophage colony stimulating factor and interleukin-5 transduce signals through two STAT5 homologs.	STAT5A STAT5B	2.05e-05	2	158	2	7720707
Pubmed	STAT5A and STAT5B have opposite correlations with drug response gene expression.	STAT5A STAT5B	2.05e-05	2	158	2	27264955
Pubmed	Nongenomic STAT5-dependent effects on Golgi apparatus and endoplasmic reticulum structure and function.	STAT5A STAT5B	2.05e-05	2	158	2	22159083
Pubmed	STAT5 requires the N-domain for suppression of miR15/16, induction of bcl-2, and survival signaling in myeloproliferative disease.	STAT5A STAT5B	2.05e-05	2	158	2	20008792
Pubmed	STAT5 Regulation of Sex-Dependent Hepatic CpG Methylation at Distal Regulatory Elements Mapping to Sex-Biased Genes.	STAT5A STAT5B	2.05e-05	2	158	2	33199496
Pubmed	A mechano-signalling network linking microtubules, myosin IIA filaments and integrin-based adhesions.	KANK2 KANK1	2.05e-05	2	158	2	31114072
Pubmed	Retinoic acid inhibits adipogenesis via activation of Wnt signaling pathway in 3T3-L1 preadipocytes.	WNT1 WNT4	2.05e-05	2	158	2	23583383
Pubmed	The influence of STAT5 antisense oligodeoxynucleotides on the proliferation and apoptosis of selected human cutaneous T-cell lymphoma cell lines.	STAT5A STAT5B	2.05e-05	2	158	2	16502315
Pubmed	Stat5: an essential regulator of mast cell biology.	STAT5A STAT5B	2.05e-05	2	158	2	12217382
Pubmed	Inactivation of RARβ inhibits Wnt1-induced mammary tumorigenesis by suppressing epithelial-mesenchymal transitions.	RARB WNT1	2.05e-05	2	158	2	25422594
Pubmed	Brain STAT5 Modulates Long-Term Metabolic and Epigenetic Changes Induced by Pregnancy and Lactation in Female Mice.	STAT5A STAT5B	2.05e-05	2	158	2	31599926
Pubmed	Taf1 knockout is lethal in embryonic male mice and heterozygous females show weight and movement disorders.	TAF1 TAF1L	2.05e-05	2	158	2	38804708
Pubmed	DNA binding site selection of dimeric and tetrameric Stat5 proteins reveals a large repertoire of divergent tetrameric Stat5a binding sites.	STAT5A STAT5B	2.05e-05	2	158	2	10594041
Pubmed	Mitochondrial translocation of signal transducer and activator of transcription 5 (STAT5) in leukemic T cells and cytokine-stimulated cells.	STAT5A STAT5B	2.05e-05	2	158	2	21036145
Pubmed	Stimulation of lipolysis but not of leptin release by growth hormone is abolished in adipose tissue from Stat5a and b knockout mice.	STAT5A STAT5B	2.05e-05	2	158	2	10486277
Pubmed	Biological functional annotation of retinoic acid alpha and beta in mouse liver based on genome-wide binding.	RARA RARB	2.05e-05	2	158	2	24833708
Pubmed	Identification of human STAT5-dependent gene regulatory elements based on interspecies homology.	STAT5A STAT5B	2.05e-05	2	158	2	16840779
Pubmed	The role of the STAT5 proteins in the proliferation and apoptosis of the CML and AML cells.	STAT5A STAT5B	2.05e-05	2	158	2	15128421
Pubmed	STAT5 deficiency in hepatocytes reduces diethylnitrosamine-induced liver tumorigenesis in mice.	STAT5A STAT5B	2.05e-05	2	158	2	30377054
Pubmed	Gain-of-function of Stat5 leads to excessive granulopoiesis and lethal extravasation of granulocytes to the lung.	STAT5A STAT5B	2.05e-05	2	158	2	23565285
Pubmed	Assessment of STAT5 as a potential therapy target in enzalutamide-resistant prostate cancer.	STAT5A STAT5B	2.05e-05	2	158	2	32790723
Pubmed	In vivo identification of novel STAT5 target genes.	STAT5A STAT5B	2.05e-05	2	158	2	18492722
Pubmed	Distinctive roles of STAT5a and STAT5b in sexual dimorphism of hepatic P450 gene expression. Impact of STAT5a gene disruption.	STAT5A STAT5B	2.05e-05	2	158	2	10066807
Pubmed	Molecular characterization of STAT5A- and STAT5B-encoding genes reveals extended intragenic sequence homogeneity in cattle and mouse and different degrees of divergent evolution of various domains.	STAT5A STAT5B	2.05e-05	2	158	2	10835485
Pubmed	Loss of Adipocyte STAT5 Confers Increased Depot-Specific Adiposity in Male and Female Mice That Is Not Associated With Altered Adipose Tissue Lipolysis.	STAT5A STAT5B	2.05e-05	2	158	2	35464049
Pubmed	Sustained expression of a neuron-specific isoform of the Taf1 gene in development stages and aging in mice.	TAF1 TAF1L	2.05e-05	2	158	2	22842574
Pubmed	Wnt-1 and Wnt-4 regulate thymic cellularity.	WNT1 WNT4	2.05e-05	2	158	2	11920562
Pubmed	Loss of cytokine-STAT5 signaling in the CNS and pituitary gland alters energy balance and leads to obesity.	STAT5A STAT5B	2.05e-05	2	158	2	18286195
Pubmed	Differentiating the roles of STAT5B and STAT5A in human CD4+ T cells.	STAT5A STAT5B	2.05e-05	2	158	2	23773921
Pubmed	Cloning of human Stat5B. Reconstitution of interleukin-2-induced Stat5A and Stat5B DNA binding activity in COS-7 cells.	STAT5A STAT5B	2.05e-05	2	158	2	8631883
Pubmed	Stat5 is essential for the myelo- and lymphoproliferative disease induced by TEL/JAK2.	STAT5A STAT5B	2.05e-05	2	158	2	11030348
Pubmed	Association between STAT5 polymorphisms and glioblastoma risk in Han Chinese population.	STAT5A STAT5B	2.05e-05	2	158	2	24878107
Pubmed	Regulation of eosinophil apoptosis by nitric oxide: Role of c-Jun-N-terminal kinase and signal transducer and activator of transcription 5.	STAT5A STAT5B	2.05e-05	2	158	2	12847485
Pubmed	Stat5 synergizes with T cell receptor/antigen stimulation in the development of lymphoblastic lymphoma.	STAT5A STAT5B	2.05e-05	2	158	2	12835478
Pubmed	Cloning and expression of Stat5 and an additional homologue (Stat5b) involved in prolactin signal transduction in mouse mammary tissue.	STAT5A STAT5B	2.05e-05	2	158	2	7568026
Pubmed	Identification of STAT5A and STAT5B target genes in human T cells.	STAT5A STAT5B	2.05e-05	2	158	2	24497979
Pubmed	Frameshift Mutations in the Mononucleotide Repeats of TAF1 and TAF1L Genes in Gastric and Colorectal Cancers with Regional Heterogeneity.	TAF1 TAF1L	2.05e-05	2	158	2	27571988
Pubmed	Striatal Cholinergic Dysregulation after Neonatal Decrease in X-Linked Dystonia Parkinsonism-Related TAF1 Isoforms.	TAF1 TAF1L	2.05e-05	2	158	2	34403156
Pubmed	Role of STAT5a in regulation of sex-specific gene expression in female but not male mouse liver revealed by microarray analysis.	STAT5A STAT5B	2.05e-05	2	158	2	17536022
Pubmed	STAT5 transcriptional activity is impaired by LIF in a mammary epithelial cell line.	STAT5A STAT5B	2.05e-05	2	158	2	17382296
Pubmed	STAT5 is essential for Akt/p70S6 kinase activity during IL-2-induced lymphocyte proliferation.	STAT5A STAT5B	2.05e-05	2	158	2	17911616
Pubmed	STAT5 signaling in sexually dimorphic gene expression and growth patterns.	STAT5A STAT5B	2.05e-05	2	158	2	10486314
Pubmed	The transcription factors Stat5a/b are not required for islet development but modulate pancreatic beta-cell physiology upon aging.	STAT5A STAT5B	2.05e-05	2	158	2	17599554
Pubmed	MiR-21 is under control of STAT5 but is dispensable for mammary development and lactation.	STAT5A STAT5B	2.05e-05	2	158	2	24497923
Pubmed	Reexpression of retinoic acid receptor (RAR) gamma or overexpression of RAR alpha or RAR beta in RAR gamma-null F9 cells reveals a partial functional redundancy between the three RAR types.	RARA RARB	2.05e-05	2	158	2	7644503
Pubmed	Constitutive activation of STAT5A and STAT5B regulates IgM secretion in Waldenstrom's macroglobulinemia.	STAT5A STAT5B	2.05e-05	2	158	2	24335105
Pubmed	Brain STAT5 signaling modulates learning and memory formation.	STAT5A STAT5B	2.05e-05	2	158	2	29460051
Pubmed	Polo-like kinase 3 is Golgi localized and involved in regulating Golgi fragmentation during the cell cycle.	PLK3 GOLGB1	2.05e-05	2	158	2	14980500
Pubmed	STAT5 deletion in macrophages alters ductal elongation and branching during mammary gland development.	STAT5A STAT5B	2.05e-05	2	158	2	28606561
Pubmed	Cell intrinsic defects in cytokine responsiveness of STAT5-deficient hematopoietic stem cells.	STAT5A STAT5B	2.05e-05	2	158	2	12393407
Pubmed	The structure of human STAT5A and B genes reveals two regions of nearly identical sequence and an alternative tissue specific STAT5B promoter.	STAT5A STAT5B	2.05e-05	2	158	2	12039059
Pubmed	Differential changes in responses of hypothalamic and brainstem neuronal populations to prolactin during lactation in the mouse.	STAT5A STAT5B	2.05e-05	2	158	2	21178171
Pubmed	Stat5 promotes metastatic behavior of human prostate cancer cells in vitro and in vivo.	STAT5A STAT5B	2.05e-05	2	158	2	20233708
Pubmed	Involvement of the STAT5 signaling pathway in the regulation of mouse preimplantation development.	STAT5A STAT5B	2.05e-05	2	158	2	16775227
Pubmed	STAT5 isoforms: controversies and clarifications.	STAT5A STAT5B	2.05e-05	2	158	2	17447893
Pubmed	Carbohydrate-responsive element-binding protein (ChREBP) is a negative regulator of ARNT/HIF-1beta gene expression in pancreatic islet beta-cells.	MLXIPL ARNT	2.05e-05	2	158	2	19833882
Pubmed	Regulation of human MutYH DNA glycosylase by the E3 ubiquitin ligase mule.	HUWE1 MUTYH	2.05e-05	2	158	2	24443563
Pubmed	Does acute promyelocytic leukemia patient with the STAT5B/RARa fusion gene respond well to decitabine?: A case report and literature review.	RARA STAT5B	2.05e-05	2	158	2	33120845
Pubmed	Suppressing aberrant GluN3A expression rescues synaptic and behavioral impairments in Huntington's disease models.	GRIN3A HTT	2.05e-05	2	158	2	23852340
Pubmed	Nucleotide sequence, genomic organization, and chromosomal localization of genes encoding the human NMDA receptor subunits NR3A and NR3B.	GRIN3A GRIN3B	2.05e-05	2	158	2	11735224
Pubmed	Activation of signal transducer and activator of transcription-5 in prostate cancer predicts early recurrence.	STAT5A STAT5B	2.05e-05	2	158	2	16115927
Pubmed	Sequential activation of genetic programs in mouse mammary epithelium during pregnancy depends on STAT5A/B concentration.	STAT5A STAT5B	2.05e-05	2	158	2	23275557
Pubmed	Granulocyte-macrophage colony-stimulating factor (GM-CSF)-induced STAT5 activation and target-gene expression during human monocyte/macrophage differentiation.	STAT5A STAT5B	2.05e-05	2	158	2	11867689
Pubmed	Global analysis of IL-2 target genes: identification of chromosomal clusters of expressed genes.	STAT5A STAT5B	2.05e-05	2	158	2	15980098
Pubmed	Compartment-selective sensitivity of cardiovascular morphogenesis to combinations of retinoic acid receptor gene mutations.	RARA RARB	2.05e-05	2	158	2	9168777
Pubmed	Inactivation of Stat5 in mouse mammary epithelium during pregnancy reveals distinct functions in cell proliferation, survival, and differentiation.	STAT5A STAT5B	2.05e-05	2	158	2	15340066
Pubmed	Selenophosphate synthetase genes from lung adenocarcinoma cells: Sps1 for recycling L-selenocysteine and Sps2 for selenite assimilation.	SEPHS2 SEPHS1	2.05e-05	2	158	2	15534230
Pubmed	STAT5A/B gene locus undergoes amplification during human prostate cancer progression.	STAT5A STAT5B	2.05e-05	2	158	2	23660011
Pubmed	Role of Stat5 in type I interferon-signaling and transcriptional regulation.	STAT5A STAT5B	2.05e-05	2	158	2	12901872
Pubmed	Retinoic acid regulates gene expression of retinoic acid receptors alpha, beta and gamma in F9 mouse teratocarcinoma cells.	RARA RARB	2.05e-05	2	158	2	1334013
Pubmed	O-GlcNAcylation of STAT5 controls tyrosine phosphorylation and oncogenic transcription in STAT5-dependent malignancies.	STAT5A STAT5B	2.05e-05	2	158	2	28074064
Pubmed	STAT5b: A master regulator of key biological pathways.	STAT5A STAT5B	2.05e-05	2	158	2	36755813
Pubmed	Identification of isoform-specific dynamics in phosphorylation-dependent STAT5 dimerization by quantitative mass spectrometry and mathematical modeling.	STAT5A STAT5B	2.05e-05	2	158	2	25333863
Pubmed	A role for STAT5 in the pathogenesis of IL-2-induced glucocorticoid resistance.	STAT5A STAT5B	2.05e-05	2	158	2	12421978
Pubmed	A single amino acid in the DNA binding regions of STAT5A and STAT5B confers distinct DNA binding specificities.	STAT5A STAT5B	2.05e-05	2	158	2	9852045
Pubmed	Signal transducer and activator of transcription (STAT)-5A and STAT5B differentially regulate human mammary carcinoma cell behavior.	STAT5A STAT5B	2.05e-05	2	158	2	19966185
Cytoband	1p34.1	ZSWIM5 ARMH1 PLK3 MUTYH	4.63e-05	57	158	4	1p34.1
Cytoband	6p22.2-p21.31	OR12D2 OR12D1	1.17e-04	5	158	2	6p22.2-p21.31
GeneFamily	Olfactory receptors, family 12	OR12D2 OR12D1	1.08e-04	3	109	2	160
GeneFamily	Ankyrin repeat domain containing\|KN motif and ankyrin repeat domain containing	KANK2 KANK1	2.14e-04	4	109	2	623
GeneFamily	Rho GTPase activating proteins\|BCH domain containing	ARHGAP30 ARHGAP11A ARHGAP31 ARHGAP33	2.33e-04	50	109	4	721
GeneFamily	Ankyrin repeat domain containing	ANKRD31 ANKRD50 KANK2 KANK1 ANKDD1B PLA2G6 TANC1	6.61e-04	242	109	7	403
GeneFamily	Glutamate ionotropic receptor NMDA type subunits	GRIN3A GRIN3B	7.42e-04	7	109	2	1201
ToppCell	Control_saline\|World / Treatment groups by lineage, cell group, cell type	FRAS1 ZBTB38 NCKAP5 ANKRD50 PTPRM NFIB HPGD TANC1	5.81e-07	199	158	8	11c9c1779caceb725ecccf3f23b7d4e6dbd1af64
ToppCell	primary_visual_cortex-Neuronal-glutamatergic_neuron\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	CACNA1E WNT4 PEX5L KIAA1549L SYNJ2 KCNMA1 R3HDM1	4.64e-06	186	158	7	56c139e679d640ea901ead657a8e8887e0fca098
ToppCell	Smart-start-Cell-Wel_seq-Neoplastic-Stem-like-OPC-like-OPC-like-F\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	FRAS1 GCM2 RFX6 CSMD3 USH2A TAF1L MUC6	5.92e-06	193	158	7	315840bc48899f3a36d57b19197509de19716e3d
ToppCell	human_hepatoblastoma-Tumor_cells\|human_hepatoblastoma / Sample and Cell Type and Tumor Cluster (all cells)	FRAS1 RHBG ZSWIM5 DIDO1 DNAH14 MLXIPL KANK1	5.92e-06	193	158	7	503a979328c68b096680b71359a26f02fafdff35
ToppCell	Control_saline-Endothelial-Endothelial-Gen_Cap\|Control_saline / Treatment groups by lineage, cell group, cell type	LRRC32 OAS2 NCKAP5 PTPRM NFIB HPGD NR5A2	7.47e-06	200	158	7	3b97920e1e6e2f09ddba2a861baa9c00c2970f4c
ToppCell	Neuronal-Inhibitory-iA\|Neuronal / cells hierarchy compared to all cells using T-Statistic	LYPD6B NCKAP5 ARL4C PTPRM ARHGAP31 NFIB GRIN3A	7.47e-06	200	158	7	5ef4a3dc18a44292184a59ced916183c0699b01e
ToppCell	LPS_anti-TNF-Endothelial-Endothelial-Activated_Gen_Cap\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	LRRC32 OAS2 NCKAP5 PTPRM NFIB HPGD NR5A2	7.47e-06	200	158	7	f15fffefe372005c33e31845982e2d2714ac26af
ToppCell	facs-Lung-24m-Endothelial-capillary_endothelial-capillary_endothelial_cell-capillary_type_1_endothelial_cell\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	FRAS1 CSMD3 KIAA1549L GUCY2F DMBT1 USH2A	2.48e-05	162	158	6	bf886e22ff2a20353499004b53f25fb9e6574896
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	TCTE1 LYPD6B AQP7B KIAA1549L ARHGAP31 NR5A2	3.71e-05	174	158	6	3d4c05ea5719ca65e85d1f15198453034791087c
ToppCell	3'-Adult-Appendix-Epithelial-mature_enterocytic\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	RNF13 FSIP2 KANK1 ARHGAP31 ANKDD1B ZNF221	3.95e-05	176	158	6	30adf8f1638c6244586f8101c2590bb964dfae00
ToppCell	3'-Adult-Appendix-Epithelial-mature_enterocytic-Colonocyte\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	RNF13 FSIP2 KANK1 ARHGAP31 ANKDD1B ZNF221	3.95e-05	176	158	6	23fa02d4c39e0b8faa1658116d50b6233a952ccc
ToppCell	Control\|World / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	FRAS1 ZBTB38 NCKAP5 PTPRM HPGD TANC1	4.08e-05	177	158	6	b8ff6940e31b749776e81ae4f5bbd577dba9749c
ToppCell	3'-Distal_airway-Endothelial-Blood_vessel_EC-vein_endothelial_cell-EC_venous_systemic-EC_venous_systemic_L.2.2.0.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	LRRC32 OAS2 ADARB1 AMOTL1 NR5A2 HRH4	4.08e-05	177	158	6	1921226196b2ab7919d9f843e60d9f4bd9ec9c57
ToppCell	facs-Pancreas-Exocrine-3m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FRAS1 COL6A6 RFX6 PEX5L MLXIPL RTL1	4.21e-05	178	158	6	fcbbcc44271515de1969b4732b6441c012693d5f
ToppCell	COVID-19-kidney-AQP1+SLC14A1+EC\|COVID-19 / Disease (COVID-19 only), tissue and cell type	LYPD6B LRRC32 KIAA1549L PTPRM SYNJ2 ARHGAP31	4.34e-05	179	158	6	1ce8d18f63e8dd2d3db41fbeca4601bd3b305fba
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L1_LAMP5_NDNF\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	LYPD6B FRAS1 DNAH14 ARL4C PTPRM GRIN3A	5.87e-05	189	158	6	f0aaf2994d319a39877d2845eaab9f166adead4e
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	LYPD6B ARL4C PTPRM ARHGAP31 NFIB GRIN3A	6.04e-05	190	158	6	56cc761e50fddfb5366391518b4d8e16589b6b42
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_1\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	LYPD6B ARL4C PTPRM ARHGAP31 NFIB GRIN3A	6.04e-05	190	158	6	25d4b591f75c26e404a34c42f1742d580af6598d
ToppCell	LPS-antiTNF-Endothelial-Endothelial-Activated_Alv_Cap\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	FRAS1 OAS2 PTPRM ARHGAP31 HPGD TANC1	6.40e-05	192	158	6	c618ede75dce3988c87a5b8f98d8e94e1dd66efd
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L1-4_LAMP5_DUSP4_(Lamp5_Rosehip)\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ARL4C PTPRM ARHGAP31 NFIB GRIN3A PLXNA1	6.40e-05	192	158	6	63d1b3efe93e5ff939278ebe40bacb38218ea09b
ToppCell	facs-Liver-Non-hepatocytes-24m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DUSP3 LRRC32 BGN ARHGAP31 NFIB AMOTL1	6.40e-05	192	158	6	2bfac6b3956265205ca47d06888851ed68b65999
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L1-4_LAMP5_DUSP4_(Lamp5_Rosehip)\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ARL4C PTPRM ARHGAP31 NFIB GRIN3A PLXNA1	6.40e-05	192	158	6	342842378c20267c5044bdd622515e8b9f895623
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L1-4_LAMP5_DUSP4_(Lamp5_Rosehip)\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ARL4C PTPRM ARHGAP31 NFIB GRIN3A PLXNA1	6.40e-05	192	158	6	bd3fa6c8fcb618db64d11f25cabaf08608957c35
ToppCell	facs-Liver-Non-hepatocytes-24m-Endothelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DUSP3 LRRC32 BGN ARHGAP31 NFIB AMOTL1	6.40e-05	192	158	6	d525f7f088a53110912600a7c9f6d33b9270d534
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	LYPD6B LRRC32 SYNJ2 ARHGAP31 HPGD NR5A2	6.40e-05	192	158	6	56b021c297a21dff357531f21e2464f85186106d
ToppCell	COPD-Stromal-Myofibroblast\|Stromal / Disease state, Lineage and Cell class	FRAS1 RARB COL6A6 ADARB1 PTPRM TANC1	6.40e-05	192	158	6	62904f94dfce430456f05066522cbf9bd29f4d7e
ToppCell	LPS-IL1RA+antiTNF-Endothelial-Endothelial-Gen_Cap\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	NCKAP5 PTPRM ARHGAP31 NFIB HPGD NR5A2	6.59e-05	193	158	6	e09387af84d2a0a526e54d4793e6e06c6739db53
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_1\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	LYPD6B ARL4C PTPRM ARHGAP31 NFIB GRIN3A	6.59e-05	193	158	6	294cb5b580bb83fe0eb04f112d5507aac35d4d44
ToppCell	LPS-antiTNF-Endothelial-Endothelial-Gen_Cap\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	NCKAP5 PTPRM ARHGAP31 NFIB HPGD NR5A2	6.59e-05	193	158	6	6e1982d089a9de628e6006d23ff78a223fbd9f47
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	LYPD6B KIAA1549L PTPRM SYNJ2 ARHGAP31 NR5A2	6.59e-05	193	158	6	2e72309607902dabe3218888b22a77fe941f3570
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	LYPD6B LRRC32 SYNJ2 HPGD NR5A2 C1QTNF3	6.59e-05	193	158	6	cc355b2ed6510619cad969ae074126d7c8db784d
ToppCell	LPS-IL1RA-Endothelial-Endothelial-Activated_Alv_Cap\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	OAS2 ANKRD50 PTPRM ARHGAP31 HPGD TANC1	6.59e-05	193	158	6	a3636c35ed25aabe2f1aba016c9fe125327bbfaf
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	LYPD6B LRRC32 KIAA1549L SYNJ2 ARHGAP31 NR5A2	6.59e-05	193	158	6	6a623acd1adad9a78eddc32ffedb16352ad3fdfa
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	LYPD6B ARL4C PTPRM ARHGAP31 NFIB GRIN3A	6.59e-05	193	158	6	3d3c45d5ff6f3396a1990615aae9fe176e799994
ToppCell	droplet-Pancreas-Endocrine-21m-Epithelial\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	WNT4 HUWE1 MLXIPL SEC16A GAA GOLGB1	6.78e-05	194	158	6	0b023de48ed8a550d169bbe954881eb04bf4f981
ToppCell	3'-Adult-Appendix-Endothelial-blood_vessel_EC-Mature_venous_EC\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	LRRC32 LAMA5 PTPRM POLL PLXNA1 ZNF345	6.98e-05	195	158	6	6a0460d949ccda7c9fe76870d3ee6c2f60677d61
ToppCell	droplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL6A6 RFX6 HUWE1 MLXIPL SEC16A GOLGB1	6.98e-05	195	158	6	3e519cffa6144a62b06124642a14c9ff39b76554
ToppCell	droplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL6A6 RFX6 HUWE1 MLXIPL SEC16A GOLGB1	6.98e-05	195	158	6	7796ea9247f4c63762f0de8490fed08b9717fa23
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	LRRC32 ADARB1 PTPRM SYNJ2 ARHGAP31 NR5A2	7.18e-05	196	158	6	8ad8efb631164b46f0c082572270188e5ead20bf
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	LRRC32 ADARB1 PTPRM SYNJ2 ARHGAP31 NR5A2	7.18e-05	196	158	6	9606ea7e42f707e69ea891b3521037613b9675f5
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	LYPD6B LRRC32 PTPRM SYNJ2 ARHGAP31 NR5A2	7.59e-05	198	158	6	b027a141ab531d0f5d6a26811a53427e7b0771dd
ToppCell	facs-Brain_Non-Myeloid-Striatum-24m-Macroglial-astrocyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PLCXD1 CUL9 HEPH SLC16A5 HTT	7.76e-05	123	158	5	a45d6907c041ad3f3218cd46dccfc25d4bd961cb
ToppCell	Sigmoid-T_cell-Tcm\|T_cell / Region, Cell class and subclass	CTSF WNT1 DHRS11 SLC25A37 RFWD3 PLA2G6	7.80e-05	199	158	6	acdf95f4d58df47690f4ae254245bc618f9ac07e
ToppCell	LPS_only-Endothelial-Endothelial-Gen_Cap\|LPS_only / Treatment groups by lineage, cell group, cell type	OAS2 NCKAP5 PTPRM NFIB HPGD NR5A2	8.02e-05	200	158	6	eb94a5111ef0e903ee5be9f7efe571b4e6d5fce1
ToppCell	10x5'v1-week_14-16-Mesenchymal_osteo-stroma-osteochondral_precursor\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	FRAS1 RARB WNT4 BGN KIAA1549L TANC1	8.02e-05	200	158	6	ad3fb8ef0be45032369d1325024787fbe1dfb8d6
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-10w-Neuroepithelial\|10w / Sample Type, Dataset, Time_group, and Cell type.	FRAS1 LRRC32 DCT KANK2 BGN ARNT	8.02e-05	200	158	6	ff0b2675c68e9fc1fa16b3276431f199f3642eac
ToppCell	Control_saline-Endothelial-Endothelial\|Control_saline / Treatment groups by lineage, cell group, cell type	OAS2 NCKAP5 PTPRM NFIB HPGD TANC1	8.02e-05	200	158	6	e77eba6172cabf85b8028638ed35299f2f079cd8
ToppCell	Neuronal-Inhibitory-iB-iB_4(SST)\|Neuronal / cells hierarchy compared to all cells using T-Statistic	NEK3 PTPRM HPGD AMOTL1 TANC1 GRIN3A	8.02e-05	200	158	6	347a510755374c6a66acee326565dfc447993f18
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-10w-Neuroepithelial-Proteoglycan-expressing_cell\|10w / Sample Type, Dataset, Time_group, and Cell type.	FRAS1 LRRC32 DCT KANK2 BGN ARNT	8.02e-05	200	158	6	07d2133c85e0a4eb8bef653ee15ecd0f1b2bbd44
ToppCell	LPS_IL1RA_TNF-Endothelial-Endothelial-Gen_Cap\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	OAS2 NCKAP5 PTPRM NFIB HPGD NR5A2	8.02e-05	200	158	6	b2d4e6f3e8e4da62e6b02758ab2ed8f505269f9a
ToppCell	Control_saline-Endothelial\|Control_saline / Treatment groups by lineage, cell group, cell type	OAS2 NCKAP5 PTPRM NFIB HPGD TANC1	8.02e-05	200	158	6	3372c488a39fe812fa94e4f0564594186fea3db5
ToppCell	PBMC-Severe-Lymphocyte-T/NK-CD4+_T-Treg-Treg_0\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	LRRC32 STAT5B ARL4C OR12D2 HPGD	1.01e-04	130	158	5	d47d4ff1263815896470d854d25306eb36919e70
ToppCell	primary_visual_cortex-Neuronal-GABAergic_neuron-Sst-Sst_Rxfp1_Eya1\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	LYPD6B RARB MMP27 ARMCX6 GRIN3A	1.16e-04	134	158	5	657ad905b40ec3f82acdef824431b8276d291ef7
Drug	Sulfathiazole [72-14-0]; Up 200; 15.6uM; MCF7; HT_HG-U133A	CTSF RARB WNK1 DCT BGN SPTBN5 ERG28 SYNJ2 NR5A2 KCNMA1	9.93e-07	200	152	10	4769_UP
Drug	Nomegestrol acetate [58652-20-3]; Down 200; 10.8uM; MCF7; HT_HG-U133A	RARA WNK1 BGN STAT5B ARL4C ARNT C1QTNF3 TAF1 ARHGAP33	7.02e-06	196	152	9	5461_DN
Drug	1-phenylbiguanide hydrochloride; Up 200; 10uM; MCF7; HG-U133A	TCEA2 RARA ADAM20 GPATCH2 AMBRA1 ADARB1 YLPM1 PLA2G6 TAF1	7.32e-06	197	152	9	22_UP
Drug	Mafenide hydrochloride [138-37-4]; Up 200; 18uM; MCF7; HT_HG-U133A	CTSF RHBG ADAM20 CUL9 ADARB1 ARL4C TRAFD1 KIAA1549L SLC16A5	7.32e-06	197	152	9	5499_UP
Drug	Denatonium benzoate [3734-33-6]; Down 200; 9uM; MCF7; HT_HG-U133A	SEMA4F RHBG AMBRA1 SLC25A37 ARNT SYNJ2 NFIB PLXNA1 GOLGB1	7.62e-06	198	152	9	6502_DN
Drug	Brinzolamide [138890-62-7]; Down 200; 10.4uM; HL60; HG-U133A	SDHAF1 SLC25A37 BAP1 ARNT KANK1 YLPM1 PLA2G6 KAT6B PLXNA1	7.62e-06	198	152	9	1615_DN
Drug	Ro 8-8717	RARA RARB	4.43e-05	2	152	2	CID006438148
Drug	Tamibarotene	RARA RARB	4.43e-05	2	152	2	DB04942
Drug	Beta-Escin [11072-93-8]; Down 200; 3.2uM; MCF7; HT_HG-U133A	SEMA4F DIDO1 SLC25A37 ARL4C SYNJ2 POLL PLK3 PLXNA1	4.43e-05	191	152	8	3890_DN
Drug	ICI182,780; Down 200; 1uM; MCF7; HT_HG-U133A	SEMA4F FRAS1 RARA ADAM20 DUSP3 HUWE1 DCT TRAFD1	4.95e-05	194	152	8	7534_DN
Drug	ICI 182,780; Up 200; 0.01uM; MCF7; HT_HG-U133A	ACVR1 BGN ARL4C ARNT TRAFD1 YLPM1 C1QTNF3 ARHGAP33	4.95e-05	194	152	8	6955_UP
Drug	alpha-estradiol; Down 200; 0.01uM; MCF7; HT_HG-U133A_EA	LMF1 DIDO1 ARNT TRAFD1 SYNJ2 NFIB AKAP10 TAF1	4.95e-05	194	152	8	990_DN
Drug	Domperidone maleate; Up 200; 7.4uM; MCF7; HT_HG-U133A	SEMA4F CTSF RARA WNT1 OAS2 HUWE1 PEX5L NR5A2	4.95e-05	194	152	8	5701_UP
Drug	Econazole nitrate [24169-02-6]; Up 200; 9uM; HL60; HT_HG-U133A	TCEA2 RHBG WNT1 NEK3 ARNT TRAFD1 SLC16A5 POLL	5.13e-05	195	152	8	2396_UP
Drug	Naftifine hydrochloride [65473-14-5]; Down 200; 12.4uM; HL60; HT_HG-U133A	TCEA2 DHRS11 DIDO1 ARHGAP11A ARL4C TRAFD1 SYNJ2 KAT6B	5.32e-05	196	152	8	2974_DN
Drug	Ethoxyquin [91-53-2]; Down 200; 18.4uM; HL60; HT_HG-U133A	LMF1 RARA AMBRA1 ARL4C TRAFD1 PLA2G6 R3HDM1 PLK3	5.52e-05	197	152	8	2559_DN
Drug	Epiandrosterone [481-29-8]; Up 200; 13.8uM; HL60; HT_HG-U133A	RARA HUWE1 BGN ARL4C SLC16A5 NFIB YLPM1 HRH4	5.52e-05	197	152	8	2444_UP
Drug	aspirin, USP; Down 200; 100uM; MCF7; HT_HG-U133A	LAMA5 SLC25A37 ARL4C NFIB YLPM1 C1QTNF3 TAF1 GOLGB1	5.52e-05	197	152	8	5564_DN
Drug	Esculin Hydrate [531-75-9]; Up 200; 11.8uM; MCF7; HT_HG-U133A	CUL9 HEPH MLXIPL ERG28 PTPRM PLA2G6 POLL ARHGAP33	5.52e-05	197	152	8	5411_UP
Drug	Chelidonine monohydrate (+) [476-32-4]; Up 200; 10.8uM; MCF7; HT_HG-U133A	RARB WNT1 DCT TFAP2B SPTBN5 ERG28 PTPRM ARHGAP33	5.52e-05	197	152	8	2779_UP
Drug	Spectinomycin dihydrochloride [21736-83-4]; Down 200; 9.8uM; MCF7; HT_HG-U133A	LMF1 DUSP3 CDKL3 TRRAP RFWD3 KANK1 YLPM1 KAT6B	5.72e-05	198	152	8	4773_DN
Drug	Pergolide mesylate [66104-23-2]; Down 200; 9.8uM; MCF7; HT_HG-U133A	RARA SLC25A37 STAT5B NEK3 YLPM1 POLL AKAP10 TAF1	5.72e-05	198	152	8	7031_DN
Drug	Dichlorphenamide [120-97-8]; Up 200; 13.2uM; MCF7; HT_HG-U133A	USP24 KANK2 SLC25A37 ARL4C POLL TAF1 KAT6B ARHGAP33	5.92e-05	199	152	8	5286_UP
Drug	S(-)Eticlopride hydrochloride [97612-24-3]; Up 200; 10.6uM; HL60; HT_HG-U133A	LMF1 RHBG SYNPO2L TFAP2B SYNJ2 NFIB NR5A2 ARHGAP33	6.14e-05	200	152	8	3056_UP
Disease	Global developmental delay	CACNA1E RNF13 TRRAP NFIB SUPT16H TAF1	6.53e-05	133	151	6	C0557874
Disease	sleep duration, low density lipoprotein cholesterol measurement	ANKRD31 USP24 KANK2 R3HDM1 HTT	1.07e-04	91	151	5	EFO_0004611, EFO_0005271
Disease	fish oil supplement exposure measurement, low density lipoprotein cholesterol measurement	USP24 MLXIPL	1.55e-04	4	151	2	EFO_0004611, EFO_0600007
Disease	Neuralgia-Neuritis, Sciatic Nerve	RARA RARB	1.55e-04	4	151	2	C0751924
Disease	Sciatic Nerve Palsy	RARA RARB	1.55e-04	4	151	2	C0751925
Disease	Sciatic Neuropathy	RARA RARB	1.55e-04	4	151	2	C0149940
Disease	Lesion of Sciatic Nerve	RARA RARB	1.55e-04	4	151	2	C0154748
Disease	Sciatic Neuritis	RARA RARB	1.55e-04	4	151	2	C0242013
Disease	uric acid measurement	FRAS1 GPATCH2 ACVR1 ANKRD50 BIRC6 TFAP2B MLXIPL TRAFD1 NR5A2 ARMCX6 TANC1	3.19e-04	610	151	11	EFO_0004761
Disease	triglyceride measurement, very low density lipoprotein cholesterol measurement	TCEA2 LMF1 DCT ITIH3 MLXIPL PLA2G6	1.07e-03	224	151	6	EFO_0004530, EFO_0008317
Disease	Malignant neoplasm of breast	RARA RARB ZSWIM5 ACVR1 ARHGAP11A WNK1 STAT5A BGN BAP1 DAP3 SYNJ2 GUCY2F KAT6B GOLGB1	1.28e-03	1074	151	14	C0006142
Disease	hypertrophic cardiomyopathy	SYNPO2L AMBRA1 NCKAP5 MUC6	1.30e-03	92	151	4	EFO_0000538
Disease	polybrominated biphenyl measurement, gestational serum measurement, fetal genotype effect measurement, polybrominated diphenyl ether measurement	PEX5L PTPRM	1.39e-03	11	151	2	EFO_0007959, EFO_0007961, EFO_0007962, EFO_0007964
Disease	Macrocephaly	CACNA1E NFIB	1.39e-03	11	151	2	C0221355
Disease	calcium measurement	ANKRD31 RARB GCM2 PYROXD2 GPATCH2 SLC25A37 HEPH MLXIPL DMBT1 GOLGB1	1.52e-03	628	151	10	EFO_0004838
Disease	eosinophil count	TCEA2 RARB WDR36 DUSP3 LRRC32 CDKL3 OAS2 PSMD2 RFX6 GIGYF1 ACVR1 WNK1 TFAP2B STAT5B SEPHS2 TRAFD1 SEC16A	1.64e-03	1488	151	17	EFO_0004842
Disease	body surface area	LMF1 ZBTB38 RARB DIDO1 WNT4 WNK1 TFAP2B SLC25A37 PLA2G6 DOT1L	1.81e-03	643	151	10	EFO_0022196
Disease	matrix metalloproteinase measurement	MMP27 PLA2G6	1.96e-03	13	151	2	EFO_0004744
Disease	cholesteryl esters to total lipids in small VLDL percentage	ANKRD31 MLXIPL SEC16A	2.04e-03	49	151	3	EFO_0022256
Disease	cerebral atherosclerosis	NFIB ZNF221	2.27e-03	14	151	2	EFO_1000860
Disease	cognitive function measurement, self reported educational attainment	CACNA1E DHRS11 WNT4 BIRC6 TFAP2B ZNF799 ZNF443	2.42e-03	355	151	7	EFO_0004784, EFO_0008354
Disease	Peroxisome biogenesis disorders	PEX3 PEX5L	2.61e-03	15	151	2	C1832200
Disease	aspartate aminotransferase measurement, serum alanine aminotransferase measurement, low density lipoprotein triglyceride measurement, body fat percentage, high density lipoprotein cholesterol measurement, sex hormone-binding globulin measurement	ZBTB38 ADARB1 TFAP2B NFIB YLPM1 PLA2G6 HTT	2.78e-03	364	151	7	EFO_0004612, EFO_0004696, EFO_0004735, EFO_0004736, EFO_0007800, EFO_0009946
Disease	cognitive function measurement	CACNA1E LMF1 DHRS11 PYROXD2 CDKL3 PSMD2 RFX6 WNT4 CSMD3 BIRC6 TFAP2B NEK3 NFIB ZNF799 USH2A ZNF443	2.85e-03	1434	151	16	EFO_0008354
Disease	Hereditary Diffuse Gastric Cancer	RARB ZNF559 BAP1 HRH4 MUC6 MUTYH	4.08e-03	293	151	6	C1708349
Disease	lingual gyrus volume measurement	GPATCH2 NCKAP5	4.20e-03	19	151	2	EFO_0010314
Disease	Adenocarcinoma of lung (disorder)	WNK1 BAP1 GUCY2F DOT1L TAF1L	4.25e-03	206	151	5	C0152013
Disease	Stomach Neoplasms	RARB ZNF559 BAP1 HRH4 MUC6 MUTYH	4.36e-03	297	151	6	C0038356
Disease	susceptibility to vaginal yeast infection measurement	ANKRD31 PEX5L GAA	4.55e-03	65	151	3	EFO_0008412
Disease	Malignant neoplasm of stomach	RARB ZNF559 BAP1 HRH4 MUC6 MUTYH	4.58e-03	300	151	6	C0024623
Disease	birth weight	PSMD2 HEATR5A WNT4 SLC25A37 MLXIPL PLA2G6 USH2A	4.59e-03	399	151	7	EFO_0004344
Disease	urate measurement, bone density	FRAS1 LAMA5 DNAH14 FSIP2 SEC16A KCNMA1 DMBT1 KAT6B USH2A	4.72e-03	619	151	9	EFO_0003923, EFO_0004531

Protein segments in the cluster

Peptide	Gene	Start	Entry
ASAGQMLAQISRHSN	ARNT	616	P27540
ANRFIFSHDLSNGAM	ADPGK	226	Q9BRR6
MGNISSNISAFQSLH	ARL4C	1	P56559
SAAQVALQSLSHAMA	BIRC6	1611	Q9NR09
FQADHSMSGRGFNIT	CSMD3	811	Q7Z407
SNTMHLAFRSDGSVS	CSMD3	1671	Q7Z407
VHFANARNARSLLSM	CXorf58	26	Q96LI9
NRHNNFRSFFGSLML	CACNA1E	1641	Q15878
FMTHSEGIDLNNRTN	AKAP10	216	O43572
MFLSISGHSQARPSQ	ADAM20	21	O43506
MAANLSSNLFHPSVR	CDKL3	441	Q8IVW4
AAMGNTDHSNSQRLA	ARMH1	331	Q6PIY5
NILGFIASDMTSRHS	ACVR1	261	Q04771
QNGLSAVRTMEAFHF	BAP1	156	Q92560
TIRHFAMNAAATAAA	AMOTL1	696	Q8IY63
LAAASMGHASVVNTL	ANKRD50	786	Q9ULJ7
RLTNSHAMGSFSGVA	DOT1L	1516	Q8TEK3
HNFLHMLSSRSSGIQ	AMBRA1	241	Q9C0C7
QDINSHLASLSMARN	ARMCX6	151	Q7L4S7
MFLNNTTTNRHTSGE	TFAP2B	431	Q92481
FTGSAHFNRSMRALA	POLL	506	Q9UGP5
QDNLGSQFSHMSLAR	R3HDM1	541	Q15032
HDMNSGVNLQRSLSS	NFIB	251	O00712
FSDGLTLNRTQMHNA	RARA	286	P10276
FSDGLTLNRTQMHNA	RARB	286	P10826
SLHSMTNFISGLQRL	RFWD3	116	Q6PCD5
FFGARVMHNLTLNNA	RFX6	501	Q8HWS3
VMHNLTLNNASSFGS	RFX6	506	Q8HWS3
TAFGRQLMHSSNFSS	RAB11FIP4	306	Q86YS3
SASMNQRSHLGTTYL	INTS6	11	Q9UL03
LQRNMAASNIGISHS	KAT6B	1896	Q8WYB5
MFIGSFRQSGLSLNH	ANKRD31	116	Q8N7Z5
ALGLSHSNDQTALMF	MMP27	221	Q9H306
RQTSTHLQMATSFGL	MUC6	491	Q6W4X9
AARQRALNPSHFMST	TCTE1	476	Q5JU00
MATSNHSSGAEFILA	OR8D2	1	Q9GZM6
MSLQFSNGSRHVCLR	KRT28	1	Q7Z3Y7
SNAQTRLESHMFNIA	FRAS1	1441	Q86XX4
FRAGANMENHNSALA	HSFY1	216	Q96LI6
AAMQTQGLRHSAAAT	GIGYF1	451	O75420
MQFDHNAGQSRASLS	KCNMA1	1176	Q12791
HSSRQNFMGLIVALD	MGAM2	1681	Q2M2H8
RISGAHMNAAVTFTN	AQP7B	91	A0A075B734
MSTFISALRNTGHEG	IRGM	46	A1A4Y4
NLSGLQLRAHAMFSA	KIAA1109	886	Q2LD37
QLNVLSLSHSNFNGM	FSIP2	1796	Q5CZC0
AEQSRLHLSQFNSMS	PLXNA1	1836	Q9UIW2
LQHGNSMNSLSSVSL	PEX3	306	P56589
GHNQIRMIENGSLSF	BGN	261	P21810
ALMALAVSYTNTGHQ	PEX5L	396	Q8IYB4
FSNTRLSQTMLGHVG	PDE7A	431	Q13946
AFVSGAAAHMLRALQ	C19orf85	21	A0A1B0GUS0
SIIAMGNTLQSFRDH	ERG28	16	Q9UKR5
SQAGQTALMLAVSHG	KANK1	1231	Q14678
GSGMLFLSNITLAHA	LRRC24	326	Q50LG9
TALLSHMAGSVQFRQ	TUBGCP6	1651	Q96RT7
AQLHDSASFTQMSRG	KIAA1549L	1676	Q6ZVL6
ISSNMGDFLHSTDRN	LRGUK	631	Q96M69
SLALFLSNGHFVAQM	LAMA5	3391	O15230
LHSVMTSRLNFCGSN	OR12D2	156	P58182
EMFSSRSHRILNNNS	OAS2	701	P29728
AHLAMGRTLSVNTDF	ADARB1	151	P78563
NLDMAAFQSHSGLSI	HUWE1	441	Q7Z6Z7
MGGQVSASNSFSRLH	PLCXD1	1	Q9NUJ7
GRALLVQHESSNQMF	NEK3	16	P51956
SSAINHRFAGQMAAL	SMPD4	751	Q9NXE4
LRGTAHMAVTSFSIN	GRIN3A	621	Q8TCU5
LHSLMTSRLNFCGSN	OR12D1	156	P0DN82
SASAAATVSGMNLLN	PROSER1	296	Q86XN7
HNRLAMATALSAGGL	LRRC32	106	Q14392
ARHSANTSMHARNLA	ARHGAP33	451	O14559
MASLATHFSNQNSGI	C1QTNF3	121	Q9BXJ4
AFRNSSMALQQAHLL	HTT	616	P42858
GSATSIMRNLHDFAL	HEATR5A	1961	Q86XA9
SMTSFHPRGLQAARA	CDK15	51	Q96Q40
ASLVQHSRNMQFHGF	GUCY2F	376	P51841
FTQGSAMISSLSQNH	CTSF	141	Q9UBX1
RQQRAAVGVSMAHFS	DIDO1	1501	Q9BTC0
MSSHGNSLFLRESGQ	SLC1A6	1	P48664
SGHMDNRQSLLSFFQ	DNAH14	2116	Q0VDD8
SAHGVFLLNSNAMDV	GAA	306	P10253
NAAEGRSFMHVNTNA	DUSP3	61	P51452
SQAGQTALMLAVSHG	KANK2	736	Q63ZY3
SGALLQQSFLTAAHM	CUL9	1531	Q8IWT3
FQARLSRLHGMSSKN	GPATCH2	341	Q9NW75
HMQASVSRSYLQSLG	DMBT1	2131	Q9UGM3
DILSMFSAIRSQHSG	DHRS11	76	Q6UWP2
MTHALQELAAAQGSF	SPACA6	86	W5XKT8
AMATSQFHFNLRTVR	COL6A6	176	A6NMZ7
FSFMDTHNLNGRSVS	PTPRM	806	P28827
AGSMHGSIQATLTFR	OR10G2	156	Q8NGC3
AGLLNFMVNTSHVSS	OR5F1	151	O95221
ASFSAQTNMHARNLA	ARHGAP30	156	Q7Z6I6
FTRSAALAANLMNSG	HPGD	161	P15428
IASQAGATLNNLMSH	NR5A2	416	O00482
LAGRAHMAVTSFSIN	GRIN3B	521	O60391
HMAVTSFSINSARSQ	GRIN3B	526	O60391
MGSFSQSDSVALHQR	HRH4	276	Q9H3N8
FLHMGTQARQSIAAH	DAP3	21	P51398
NSFLAHFSMAQIRAV	RTL1	1061	A6NKG5
PMSALLSRQFSHTNA	RTN3	306	O95197
HASAMSLIDASGNQL	SYNPO2L	66	Q9H987
YSQGSLHRSVSQLMD	USH2A	5136	O75445
SGSNLHALMNQRQSS	ARHGAP11A	606	Q6P4F7
TNNMKLRHFGSSLSL	SEMA4F	386	O95754
ASNQLDSLMGLSNSH	TRAFD1	346	O14545
NQGQMLVTFADSHSA	SYNJ2	931	O15056
LGMNGAKARSHSFST	NCKAP5	1266	O14513
LHNSNTMRLGSIFGL	PSMD2	471	Q13200
MLLVAGSAASGNNHR	TAF1L	1151	Q8IZX4
RMLLAAGSAASGNNH	TAF1	1131	P21675
RMSAQTHGLLGQFFQ	ITIH3	801	Q06033
FDTVSGSAMLHNRQN	PRDM15	1411	P57071
SLVERTNHGQFQAMA	GCM2	341	O75603
DSNRMHAINGFLFSN	HEPH	616	Q9BQS7
NSHLANGIAGSMATL	SLC25A37	141	Q9NYZ2
QSFGALSESRSHQNM	RNF13	321	O43567
RLNRTAAGLMHTFNA	SEPHS1	246	P49903
LQQALTAAASMGHSS	TANC1	1041	Q9C0D5
HQATGTLSAHFRNMS	STAT5B	406	P51692
MGQQVLDNFFRSHIS	MUTYH	521	Q9UIF7
LQLLRSGHATAMGAF	SDHAF1	61	A6NFY7
AGNTALHVAVMRNRF	PLA2G6	316	O60733
MQGSLEAHVNGFRFT	SUPT16H	676	Q9Y5B9
SFNGMVSTASVHTLR	MLXIPL	781	Q9NP71
HASLLMASFTQAATQ	SPTBN5	2146	Q9NRC6
HQATGTLSAHFRNMS	STAT5A	406	P42229
RAKNQDGMSALHFAT	ANKDD1B	161	A6NHY2
AVLFNDGTHMALSAN	PLK3	486	Q9H4B4
RAAMFKLHLGTTQNS	VPS4B	306	O75351
ATLNRTAAGLMHTFN	SEPHS2	296	Q99611
AAGGMTHSQLFTIAR	ZSWIM5	991	Q9P217
NHGAGLFVMISSAAQ	TAS1R1	676	Q7RTX1
SLGMVASSFSHNLSQ	SLC16A5	91	O15375
MSSLSREVSQHFNQA	SEC16A	2296	O15027
AFQHGSLLQRMRSLS	PYROXD2	186	Q8N2H3
EGQRSATSQAMHQLF	RHBG	381	Q9H310
SMFNSTQSLISIGAH	TMEM107	76	Q6UX40
MSQQHSEGSRNGFSL	TTC41P	1116	Q6P2S7
KSFSSLGNLQRHMAV	ZNF799	176	Q96GE5
SVLRMDHAGNTTTFF	SERPINA13P	241	Q6UXR4
IASFSSKTNMHARNL	ARHGAP31	156	Q2M1Z3
HGLTSNVNNRMASLA	TRAV26-2	66	A0A0B4J265
MSLHNLVHSFLNGTN	DCT	366	P40126
SSSGFMSFREQHLAQ	YLPM1	46	P49750
NFRQRSALNSHSMVH	ZNF221	346	Q9UK13
HMISFLLGASRQNNQ	USP24	2311	Q9UPU5
FLMNLHNNEAGRTTV	WNT1	196	P04628
KSFSSLGNLQRHMAV	ZNF443	176	Q9Y2A4
SKGASSSRALMNLHN	WNT4	176	P56705
HQMARTGGTQTDLFT	TCEA2	246	Q15560
NAIAAMTSSNHRAFS	ZBTB38	731	Q8NAP3
GMAFSSGSALTRHQR	ZNF345	236	Q14585
GMNLSHSASSLSLQQ	WNK1	1291	Q9H4A3
GQAFSISSGLTVHMR	ZNF559	471	Q9BR84
SSNNAMLGVHASASA	TRRAP	3026	Q9Y4A5
VRATSQGGHLMSDLF	WASH6P	381	Q9NQA3
QILHSMAIDSGFRNS	TYW3	116	Q6IPR3
NQMRNAHSTAIAGLT	WDR36	326	Q8NI36
FGRSMSSLQNSRDHA	GOLGB1	2736	Q14789
LLSSRQVMNTHFNSL	LMF1	386	Q96S06
AVFAVMHAQRTSGSS	LYPD6B	151	Q8NI32