Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	LDLR_class-A_CS	NETO2 SSPOP NETO1	7.88e-05	40	39	3	IPR023415
Domain	Ldl_recept_a	NETO2 SSPOP NETO1	1.12e-04	45	39	3	PF00057
Domain	-	NETO2 SSPOP NETO1	1.20e-04	46	39	3	4.10.400.10
Domain	LDLRA_1	NETO2 SSPOP NETO1	1.36e-04	48	39	3	PS01209
Domain	LDLRA_2	NETO2 SSPOP NETO1	1.45e-04	49	39	3	PS50068
Domain	LDrepeatLR_classA_rpt	NETO2 SSPOP NETO1	1.45e-04	49	39	3	IPR002172
Domain	LDLa	NETO2 SSPOP NETO1	1.45e-04	49	39	3	SM00192
Domain	-	GLIPR1L2 CRISPLD1	4.39e-04	15	39	2	3.40.33.10
Domain	CAP	GLIPR1L2 CRISPLD1	4.39e-04	15	39	2	PF00188
Domain	CAP_domain	GLIPR1L2 CRISPLD1	4.39e-04	15	39	2	IPR014044
Domain	SCP	GLIPR1L2 CRISPLD1	4.39e-04	15	39	2	SM00198
Domain	Allrgn_V5/Tpx1	GLIPR1L2 CRISPLD1	4.39e-04	15	39	2	IPR001283
Domain	CUB	NETO2 NETO1	4.70e-03	49	39	2	PF00431
Domain	CUB	NETO2 NETO1	4.89e-03	50	39	2	SM00042
Domain	-	NETO2 NETO1	5.27e-03	52	39	2	2.60.120.290
Domain	CUB	NETO2 NETO1	5.47e-03	53	39	2	PS01180
Domain	CUB_dom	NETO2 NETO1	6.31e-03	57	39	2	IPR000859
Pathway	WP_NICOTINE_METABOLISM_IN_LIVER_CELLS	CYP2B6 AOX1	6.10e-05	6	29	2	M39600
Pubmed	A novel gene encoding a putative transmembrane protein with two extracellular CUB domains and a low-density lipoprotein class A module: isolation of alternatively spliced isoforms in retina and brain.	NETO2 NETO1	1.29e-06	2	40	2	11943477
Pubmed	Neto auxiliary protein interactions regulate kainate and NMDA receptor subunit localization at mossy fiber-CA3 pyramidal cell synapses.	NETO2 NETO1	1.29e-06	2	40	2	24403160
Pubmed	Expression of Btcl2, a novel member of Btcl gene family, during development of the central nervous system.	NETO2 NETO1	1.29e-06	2	40	2	15464227
Pubmed	NETO1 Guides Development of Glutamatergic Connectivity in the Hippocampus by Regulating Axonal Kainate Receptors.	NETO2 NETO1	1.29e-06	2	40	2	28680963
Pubmed	NETO1 Regulates Postsynaptic Kainate Receptors in CA3 Interneurons During Circuit Maturation.	NETO2 NETO1	1.29e-06	2	40	2	31044365
Pubmed	Kainate receptor auxiliary subunit NETO2 is required for normal fear expression and extinction.	NETO2 NETO1	1.29e-06	2	40	2	30770891
Pubmed	Neto auxiliary proteins control both the trafficking and biophysical properties of the kainate receptor GluK1.	NETO2 NETO1	3.87e-06	3	40	2	26720915
Pubmed	Neto2 Assembles with Kainate Receptors in DRG Neurons during Development and Modulates Neurite Outgrowth in Adult Sensory Neurons.	NETO2 NETO1	3.87e-06	3	40	2	28235897
Pubmed	The auxiliary subunits Neto1 and Neto2 have distinct, subunit-dependent effects at recombinant GluK1- and GluK2-containing kainate receptors.	NETO2 NETO1	7.73e-06	4	40	2	26277340
Pubmed	Neto Auxiliary Subunits Regulate Interneuron Somatodendritic and Presynaptic Kainate Receptors to Control Network Inhibition.	NETO2 NETO1	1.29e-05	5	40	2	28854365
Pubmed	Bood POZ containing gene type 2 is a human counterpart of yeast Btb3p and promotes the degradation of terminal deoxynucleotidyltransferase.	ABTB2 DNTT	1.29e-05	5	40	2	18429817
Pubmed	Influence of pharmacogenetics on response and toxicity in breast cancer patients treated with doxorubicin and cyclophosphamide.	CYP2B6 SLC22A16	1.93e-05	6	40	2	20179710
Pubmed	Neto1 is an auxiliary subunit of native synaptic kainate receptors.	NETO2 NETO1	1.93e-05	6	40	2	21734292
Pubmed	Mapping of mouse gamma crystallin genes on chromosome 1.	SLC11A1 AOX1	2.70e-05	7	40	2	3242494
Pubmed	A dual-strategy expression screen for candidate connectivity labels in the developing thalamus.	LGI2 NETO2 NETO1	1.60e-04	91	40	3	28558017
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	OGDHL TEP1 STK11IP ABTB2 MYORG HTT KLHL17	2.39e-04	1105	40	7	35748872
Pubmed	PlexinA1 signaling directs the segregation of proprioceptive sensory axons in the developing spinal cord.	NETO2 NETO1 SEMA3E	3.35e-04	117	40	3	17145500
Pubmed	ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.	TMEM30A ARL6IP6 NETO2 DEGS1 B3GAT3 MYORG HTT	3.95e-04	1201	40	7	35696571
Pubmed	Fezl regulates the differentiation and axon targeting of layer 5 subcortical projection neurons in cerebral cortex.	NETO2 NETO1 SEMA3E	4.16e-04	126	40	3	16284245
Pubmed	Ctip2 controls the differentiation of medium spiny neurons and the establishment of the cellular architecture of the striatum.	NETO1 SEMA3E	6.66e-04	33	40	2	18199763
Cytoband	2q35	SLC11A1 STK11IP	2.19e-03	79	40	2	2q35
GeneFamily	Ankyrin repeat domain containing\|FERM domain containing	MYO15B PTK2	1.99e-03	50	24	2	1293
Disease	tuberculosis (is_implicated_in)	CYP2B6 SLC11A1	5.67e-04	28	37	2	DOID:399 (is_implicated_in)
Disease	neurodegenerative disease (implicated_via_orthology)	OGDHL DEGS1 HTT	7.99e-04	145	37	3	DOID:1289 (implicated_via_orthology)
Disease	histidine measurement	ARL6IP6 SNX17	3.12e-03	66	37	2	EFO_0009769
Disease	squamous cell lung carcinoma, family history of lung cancer	PTK2 TLX3	5.12e-03	85	37	2	EFO_0000708, EFO_0006953
Disease	phosphatidylcholine measurement	MYO15B PTK2 SNX17	5.38e-03	284	37	3	EFO_0010226

Protein segments in the cluster

Peptide	Gene	Start	Entry
ERRMGTAVGRSEVWF	CHTF18	941	Q8WVB6
RELFEEMRWTRGVSV	B3GAT3	201	O94766
MWELRSIAFSRAVFA	AQP2	1	P41181
WKVLRRFSVTTMRDF	CYP2B6	121	P20813
FSVGRVYRWMVDSRV	BTBD11	211	A6QL63
QRTRVFGSERMMWFS	AOX1	231	Q06278
RFSSRAESFMFRTWG	MTAP	176	Q13126
VIRMWADEGSRNSRF	NETO1	266	Q8TDF5
RFMTWDVALSRTARA	GLIPR1L2	76	Q4G1C9
LGQVFRSRDTWMTSR	PNMA6F	326	A0A0J9YX94
VRSMRFEDFLARKWS	OGDHL	246	Q9ULD0
VMEGFLRLRWSRFAR	SLC11A1	386	P49279
RREAEWGRVATVMYT	OR1K1	266	Q8NGR3
AGWRRGRMALDVFTF	MYO15B	641	Q96JP2
SRSRFHVGDWMGTIR	HTT	781	P42858
GTWTSVAAMSTRRRY	KLHL17	461	Q6TDP4
RVTFPVRSSMVRAAW	FAM151A	241	Q8WW52
REWLRVTTVLFMARA	CRISPLD1	6	Q9H336
MGSRVSREDFEWVYT	DEGS1	1	O15121
DFIVWMRTAALPTFR	TMEM30A	256	Q9NV96
MEVRWFRSQFSPAVF	BTN2A2	66	Q8WVV5
MFFSEARARSRTWEA	EFCAB11	1	Q9BUY7
LELMSSFRERFGRNW	STK11IP	416	Q8N1F8
RRVFMWTVSGTPCRE	MRPL50	11	Q8N5N7
AVWTFGRMVQARFVR	SSPOP	2191	A2VEC9
WFRMGFRTLSKVRSD	DNTT	266	P04053
LTRFIGDSRVMRWNS	LGI2	436	Q8N0V4
RRALAAAFRMWSDVS	MMP23B	111	O75900
RRVVLWATSSSMFLF	SLC22A16	181	Q86VW1
FRRFTSASDVWMFGV	PTK2	596	Q05397
FREVTRRTARMVAEW	SELENOO	311	Q9BVL4
MRRRVFSSQDWRASG	SCOC	1	Q9UIL1
VIRMWADEGSRLSRF	NETO2	271	Q8NC67
SVGRFFRWMVDTRIS	ABTB2	206	Q8N961
WSFREMGDLTRRVAN	ACSM1	86	Q08AH1
MSFAESGWRSALRRR	ARL6IP6	1	Q8N6S5
GSFRVTRMRCWRVTS	SNX17	311	Q15036
WRSIRLFISSTFRDM	TEP1	896	Q99973
PWMESSRRFVKDRFT	TLX3	126	O43711
WSRDAAIFRSMGRLA	SEMA3E	196	O15041
MFRRLRDAGFRVTLW	MYORG	376	Q6NSJ0