Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	gonadal mesoderm development	TSPY3 TSPY2 TSPY8 TSPY1 TSPY10	2.67e-09	9	154	5	GO:0007506
GeneOntologyBiologicalProcess	negative regulation of ceramide biosynthetic process	ORMDL1 ORMDL3 ORMDL2	4.04e-06	5	154	3	GO:1900060
GeneOntologyBiologicalProcess	intracellular sphingolipid homeostasis	ORMDL1 ORMDL3 ORMDL2	8.03e-06	6	154	3	GO:0090156
GeneOntologyBiologicalProcess	negative regulation of sphingolipid biosynthetic process	ORMDL1 ORMDL3 ORMDL2	1.40e-05	7	154	3	GO:0090155
GeneOntologyBiologicalProcess	homophilic cell adhesion via plasma membrane adhesion molecules	DCHS2 CLSTN3 PCDHB12 CADM2 FAT1 FAT2 DCHS1 CDH7	8.31e-05	187	154	8	GO:0007156
GeneOntologyCellularComponent	serine palmitoyltransferase complex	ORMDL1 ORMDL3 ORMDL2	2.31e-05	8	158	3	GO:0017059
GeneOntologyCellularComponent	eukaryotic translation initiation factor 3 complex, eIF3m	EIF3CL EIF3A EIF3C	3.44e-05	9	158	3	GO:0071541
GeneOntologyCellularComponent	palmitoyltransferase complex	ORMDL1 ORMDL3 ORMDL2	6.69e-05	11	158	3	GO:0002178
GeneOntologyCellularComponent	eukaryotic translation initiation factor 3 complex	EIF3CL EIF3A EIF3C	2.21e-04	16	158	3	GO:0005852
GeneOntologyCellularComponent	eukaryotic 48S preinitiation complex	EIF3CL EIF3A EIF3C	3.18e-04	18	158	3	GO:0033290
GeneOntologyCellularComponent	eukaryotic 43S preinitiation complex	EIF3CL EIF3A EIF3C	3.76e-04	19	158	3	GO:0016282
GeneOntologyCellularComponent	translation preinitiation complex	EIF3CL EIF3A EIF3C	4.39e-04	20	158	3	GO:0070993
GeneOntologyCellularComponent	integrator complex	INTS7 INTS1 SAGE1	5.10e-04	21	158	3	GO:0032039
GeneOntologyCellularComponent	main axon	KIF13B SPTBN1 APP SCN8A PARD3	5.76e-04	89	158	5	GO:0044304
HumanPheno	Low hanging columella	ZNF148 AFF3 SRCAP CLCN3 ASXL3 CEP295 CTNNB1	1.78e-06	56	55	7	HP:0009765
HumanPheno	Thin upper lip vermilion	ATRX SPTBN1 AFF3 DYRK1A ZNF407 POGZ SRCAP RFX7 CLCN3 ASXL3 ANKRD17 CEP295 CTNNB1	4.49e-05	339	55	13	HP:0000219
HumanPheno	Thin lips	ATRX SPTBN1 AFF3 DYRK1A ZNF407 POGZ SRCAP RFX7 CLCN3 ASXL3 ANKRD17 CEP295 CTNNB1	4.49e-05	339	55	13	HP:0000213
HumanPheno	Abnormal columella morphology	ZNF148 AFF3 SRCAP CLCN3 ASXL3 CEP295 CTNNB1	7.02e-05	97	55	7	HP:0009929
HumanPheno	Abnormality of upper lip vermillion	ATRX SPTBN1 AFF3 DYRK1A ZNF407 POGZ SRCAP RFX7 EPG5 CLCN3 ASXL3 DCHS1 ANKRD17 CEP295 CTNNB1	7.60e-05	464	55	15	HP:0011339
Domain	ORMDL	ORMDL1 ORMDL3 ORMDL2	5.61e-07	3	155	3	IPR007203
Domain	ORMDL	ORMDL1 ORMDL3 ORMDL2	5.61e-07	3	155	3	PF04061
Domain	LRRC37AB_C	LRRC37A3 LRRC37A2 LRRC37A	2.23e-06	4	155	3	IPR029423
Domain	LRRC37AB_C	LRRC37A3 LRRC37A2 LRRC37A	2.23e-06	4	155	3	PF14914
Domain	LRRC37_N	LRRC37A3 LRRC37A2 LRRC37A	2.23e-06	4	155	3	IPR032754
Domain	LRRC37	LRRC37A3 LRRC37A2 LRRC37A	2.23e-06	4	155	3	PF15779
Domain	LRRC37A/B-like	LRRC37A3 LRRC37A2 LRRC37A	2.23e-06	4	155	3	IPR015753
Domain	CADHERIN_1	DCHS2 CLSTN3 PCDHB12 FAT1 FAT2 DCHS1 CDH7	4.38e-05	113	155	7	PS00232
Domain	Cadherin	DCHS2 CLSTN3 PCDHB12 FAT1 FAT2 DCHS1 CDH7	4.38e-05	113	155	7	PF00028
Domain	CADHERIN_2	DCHS2 CLSTN3 PCDHB12 FAT1 FAT2 DCHS1 CDH7	4.64e-05	114	155	7	PS50268
Domain	-	DCHS2 CLSTN3 PCDHB12 FAT1 FAT2 DCHS1 CDH7	4.64e-05	114	155	7	2.60.40.60
Domain	CA	DCHS2 CLSTN3 PCDHB12 FAT1 FAT2 DCHS1 CDH7	4.90e-05	115	155	7	SM00112
Domain	Cadherin-like	DCHS2 CLSTN3 PCDHB12 FAT1 FAT2 DCHS1 CDH7	5.18e-05	116	155	7	IPR015919
Domain	Cadherin	DCHS2 CLSTN3 PCDHB12 FAT1 FAT2 DCHS1 CDH7	5.78e-05	118	155	7	IPR002126
Domain	EIF3C_N_dom	EIF3CL EIF3C	6.84e-05	2	155	2	IPR008905
Domain	eIF-3c_N	EIF3CL EIF3C	6.84e-05	2	155	2	PF05470
Domain	EIF3C	EIF3CL EIF3C	6.84e-05	2	155	2	IPR027516
Domain	PINT	EIF3CL EIF3A EIF3C	2.90e-04	16	155	3	SM00088
Domain	Cadherin_CS	DCHS2 PCDHB12 FAT1 FAT2 DCHS1 CDH7	2.97e-04	109	155	6	IPR020894
Domain	PCI_dom	EIF3CL EIF3A EIF3C	3.50e-04	17	155	3	IPR000717
Domain	NAP_family	TSPY2 TSPY8 TSPY10	3.50e-04	17	155	3	IPR002164
Domain	NAP	TSPY2 TSPY8 TSPY10	3.50e-04	17	155	3	PF00956
Domain	PCI	EIF3CL EIF3A EIF3C	3.50e-04	17	155	3	PF01399
Domain	Glyco_hydro_31_CS	SI GAA	4.06e-04	4	155	2	IPR030459
Domain	Spectrin_bsu	SPTB SPTBN1	4.06e-04	4	155	2	IPR016343
Domain	Gal_mutarotase_N	SI GAA	4.06e-04	4	155	2	IPR031727
Domain	NtCtMGAM_N	SI GAA	4.06e-04	4	155	2	PF16863
Domain	-	TFDP3 E2F5 RFX7 RFX4 EIF3CL POLR3F EIF3A EIF3C	4.80e-04	218	155	8	1.10.10.10
Domain	GLYCOSYL_HYDROL_F31_2	SI GAA	6.73e-04	5	155	2	PS00707
Domain	FBOX	FBXO16 FBXL7 FBXO33 FBXO34	9.06e-04	52	155	4	SM00256
Domain	WHTH_DNA-bd_dom	TFDP3 E2F5 RFX7 RFX4 EIF3CL POLR3F EIF3A EIF3C	9.50e-04	242	155	8	IPR011991
Domain	Glyco_hydro_31_AS	SI GAA	1.00e-03	6	155	2	IPR030458
Domain	Glyco_hydro_31	SI GAA	1.40e-03	7	155	2	IPR000322
Domain	Glyco_hydro_31	SI GAA	1.40e-03	7	155	2	PF01055
Domain	GLYCOSYL_HYDROL_F31_1	SI GAA	1.40e-03	7	155	2	PS00129
Domain	P_TREFOIL_1	SI GAA	1.85e-03	8	155	2	PS00025
Domain	Trefoil	SI GAA	1.85e-03	8	155	2	PF00088
Domain	P_trefoil_CS	SI GAA	1.85e-03	8	155	2	IPR017957
Pubmed	Expression of mouse dchs1, fjx1, and fat-j suggests conservation of the planar cell polarity pathway identified in Drosophila.	DCHS2 FAT1 FAT2 DCHS1	1.57e-08	7	162	4	16059920
Pubmed	E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.	SETX RNGTT PCDHB12 INTS1 OBSCN SLC28A3 REV3L ZZEF1 FMNL2 FBXL7 SCN8A CEP295 EIF3A NUP188 ZNF582 ITPRIPL1 FBXO34	7.08e-08	736	162	17	29676528
Pubmed	ORMDL proteins are a conserved new family of endoplasmic reticulum membrane proteins.	ORMDL1 ORMDL3 ORMDL2	9.92e-08	3	162	3	12093374
Pubmed	Simultaneous reduction of all ORMDL proteins decreases the threshold of mast cell activation.	ORMDL1 ORMDL3 ORMDL2	9.92e-08	3	162	3	37316542
Pubmed	Expression of the ORMDLS, modulators of serine palmitoyltransferase, is regulated by sphingolipids in mammalian cells.	ORMDL1 ORMDL3 ORMDL2	9.92e-08	3	162	3	25395622
Pubmed	Mammalian ORMDL proteins mediate the feedback response in ceramide biosynthesis.	ORMDL1 ORMDL3 ORMDL2	9.92e-08	3	162	3	23066021
Pubmed	Comprehensive Interactome Mapping of the DNA Repair Scaffold SLX4 Using Proximity Labeling and Affinity Purification.	RNF169 ATRX AFF3 POGZ REV3L PAF1 RESF1 PRPF3 RBM6 RACGAP1	1.02e-07	222	162	10	37071664
Pubmed	Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.	DOCK4 BDP1 KIF13B SETX RNGTT ATRX STXBP4 SRCAP PAF1 DDX1 RESF1 PIK3C2B N4BP2 RBM6 CTNNB1	1.23e-07	588	162	15	38580884
Pubmed	Orm family proteins mediate sphingolipid homeostasis.	ORMDL1 ORMDL3 ORMDL2	3.95e-07	4	162	3	20182505
Pubmed	Primate segmental duplication creates novel promoters for the LRRC37 gene family within the 17q21.31 inversion polymorphism region.	LRRC37A3 LRRC37A2 LRRC37A	3.95e-07	4	162	3	22419166
Pubmed	The Ormdl genes regulate the sphingolipid synthesis pathway to ensure proper myelination and neurologic function in mice.	ORMDL1 ORMDL3 ORMDL2	3.95e-07	4	162	3	31880535
Pubmed	Tagging genes with cassette-exchange sites.	RNF169 ZFAT ZNF148 ARHGEF12 XPO4 RFX7 EIF3CL RESF1 UTP25 TIPIN EIF3C	5.51e-07	335	162	11	15741177
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	KIF13B RNF169 ATP13A1 ZNF407 TRAPPC8 FMNL2 FAT2 CEP72 N4BP2 SUN2 EIF3A PRORP RIC1	6.08e-07	493	162	13	15368895
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	DOCK4 TET2 KIF13B KRT78 SETX STXBP4 SPTBN1 DYRK1A RFX7 DDX1 RESF1 PIK3C2B N4BP2 RACGAP1 ANKRD17 PARD3 CDC25B	6.36e-07	861	162	17	36931259
Pubmed	ORMDL/serine palmitoyltransferase stoichiometry determines effects of ORMDL3 expression on sphingolipid biosynthesis.	ORMDL1 ORMDL3 ORMDL2	1.96e-06	6	162	3	25691431
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	TNIK KIF13B SPTBN1 DYRK1A ARHGEF12 SEC31A PAF1 ITIH1 IQGAP1 N4BP2 SPHKAP DCHS1 RACGAP1 ANKRD17 PLCL1 CTNNB1 PARD3	2.89e-06	963	162	17	28671696
Pubmed	A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.	ZFAT SPTB SPTBN1 OBSCN ZNF407 SEC31A NEB PAF1 ACAA2 EIF3A EIF3C PARD3	4.12e-06	497	162	12	23414517
Pubmed	Elongin A regulates transcription in vivo through enhanced RNA polymerase processivity.	INTS7 INTS1 PAF1 PRPF3	6.26e-06	26	162	4	33298525
Pubmed	The m subunit of murine translation initiation factor eIF3 maintains the integrity of the eIF3 complex and is required for embryonic development, homeostasis, and organ size control.	EIF3CL EIF3A EIF3C	8.16e-06	9	162	3	24003236
Pubmed	The pleiotropic mouse phenotype extra-toes spotting is caused by translation initiation factor Eif3c mutations and is associated with disrupted sonic hedgehog signaling.	EIF3CL EIF3A EIF3C	8.16e-06	9	162	3	21292980
Pubmed	Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	BDP1 XPO4 ZNF407 ASXL3 SPHKAP CEP295	8.66e-06	102	162	6	11214970
Pubmed	Endogenous Cell Type-Specific Disrupted in Schizophrenia 1 Interactomes Reveal Protein Networks Associated With Neurodevelopmental Disorders.	TNIK ATP13A1 SPTBN1 DDX1 PRPF3 SUN2 RBM6	9.09e-06	156	162	7	29961565
Pubmed	Conservation and diversity of eukaryotic translation initiation factor eIF3.	EIF3CL EIF3A EIF3C	1.16e-05	10	162	3	8995409
Pubmed	Evolutionary dynamism of the primate LRRC37 gene family.	LRRC37A3 LRRC37A2 LRRC37A	1.16e-05	10	162	3	23064749
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	KIF13B SETX ATRX STXBP4 SPTBN1 OBSCN DYRK1A SEC31A FCHO2 SRCAP NOL4L RESF1 ANKRD17 CEP295 NUP188 PARD3 BRWD1	1.35e-05	1084	162	17	11544199
Pubmed	Proximity interactions of the ubiquitin ligase Mind bomb 1 reveal a role in regulation of epithelial polarity complex proteins.	E2F5 FCHO2 EIF3CL PIK3C2B CEP72 N4BP2 EIF3A	1.53e-05	169	162	7	31462741
Pubmed	Atypical Cadherin Fat1 Is Required for Lens Epithelial Cell Polarity and Proliferation but Not for Fiber Differentiation.	FAT1 DCHS1 CTNNB1	1.59e-05	11	162	3	26114487
Pubmed	Dephosphorylation of the nuclear factor of activated T cells (NFAT) transcription factor is regulated by an RNA-protein scaffold complex.	DYRK1A IQGAP1 NFATC2	1.59e-05	11	162	3	21709260
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	RNF169 ZNF148 ATRX SPTBN1 POGZ RFX7 IQGAP1 EIF3CL NOL4L RBM6 ANKRD17 EIF3C PARD3 BAG6	1.73e-05	774	162	14	15302935
Pubmed	A human MAP kinase interactome.	SETX SPTBN1 POGZ SEC31A NEB FMNL2 KIAA1549L CSN1S1 N4BP2 ANKRD17 EIF3A	1.91e-05	486	162	11	20936779
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	ZNF148 POGZ REV3L APP SRCAP ZZEF1 FMNL2 FAT1 RESF1 UTP25 PRPF3 SUN2 ANKRD17 CEP295 NUP188 PARD3 BRWD1	1.96e-05	1116	162	17	31753913
Pubmed	The Tumor Suppressor CIC Directly Regulates MAPK Pathway Genes via Histone Deacetylation.	ZNF148 SPTBN1 INTS1 DYRK1A POGZ PAF1 CREB5 DDX1 NFATC2 SUN2 EIF3A EIF3C	2.03e-05	583	162	12	29844126
Pubmed	Characterization of eIF3k: a newly discovered subunit of mammalian translation initiation factor elF3.	EIF3CL EIF3A EIF3C	2.12e-05	12	162	3	14519125
Pubmed	Reconstitution reveals the functional core of mammalian eIF3.	EIF3CL EIF3A EIF3C	2.12e-05	12	162	3	17581632
Pubmed	DOCK4 promotes loss of proliferation in glioblastoma progenitor cells through nuclear beta-catenin accumulation and subsequent miR-302-367 cluster expression.	DOCK4 CTNNB1	2.16e-05	2	162	2	28925399
Pubmed	ORMDL2 Deficiency Potentiates the ORMDL3-Dependent Changes in Mast Cell Signaling.	ORMDL3 ORMDL2	2.16e-05	2	162	2	33643282
Pubmed	EIF3C Promotes Lung Cancer Tumorigenesis by Regulating the APP/HSPA1A/LMNB1 Axis.	EIF3CL EIF3C	2.16e-05	2	162	2	36157221
Pubmed	Association of RNase L with a Ras GTPase-activating-like protein IQGAP1 in mediating the apoptosis of a human cancer cell-line.	IQGAP1 RNASEL	2.16e-05	2	162	2	20875083
Pubmed	Proteomic analysis of ischemia-reperfusion injury upon human liver transplantation reveals the protective role of IQGAP1.	IQGAP1 CTNNB1	2.16e-05	2	162	2	16622255
Pubmed	APP and DYRK1A regulate axonal and synaptic vesicle protein networks and mediate Alzheimer's pathology in trisomy 21 neurons.	DYRK1A APP	2.16e-05	2	162	2	35194165
Pubmed	The Overexpression of IQGAP1 and β-Catenin Is Associated with Tumor Progression in Hepatocellular Carcinoma In Vitro and In Vivo.	IQGAP1 CTNNB1	2.16e-05	2	162	2	26252773
Pubmed	ORMDL proteins regulate ceramide levels during sterile inflammation.	ORMDL1 ORMDL3	2.16e-05	2	162	2	27313060
Pubmed	Genetic variations of the CTNNA1 and the CTNNB1 genes in sporadic colorectal cancer in Polish population.	APP CTNNB1	2.16e-05	2	162	2	23399619
Pubmed	Nucleo-cytoplasmic shuttling of human Kank protein accompanies intracellular translocation of beta-catenin.	KANK1 CTNNB1	2.16e-05	2	162	2	16968744
Pubmed	Simultaneous deletion of ORMDL1 and ORMDL3 proteins disrupts immune cell homeostasis.	ORMDL1 ORMDL3	2.16e-05	2	162	2	38715613
Pubmed	Functional and biochemical characterization of human eukaryotic translation initiation factor 3 in living cells.	EIF3A EIF3C	2.16e-05	2	162	2	24912683
Pubmed	Autocrine lysophosphatidic acid signaling activates β-catenin and promotes lung allograft fibrosis.	NFATC2 CTNNB1	2.16e-05	2	162	2	28240604
Pubmed	The centriolar satellite proteins Cep72 and Cep290 interact and are required for recruitment of BBS proteins to the cilium.	CEP72 LRRC36	2.16e-05	2	162	2	22767577
Pubmed	Amyloid precursor protein enhances Nav1.6 sodium channel cell surface expression.	APP SCN8A	2.16e-05	2	162	2	25767117
Pubmed	Brain p3-Alcβ peptide restores neuronal viability impaired by Alzheimer's amyloid β-peptide.	CLSTN3 APP	2.16e-05	2	162	2	36994913
Pubmed	Prevention of axonal injury using calpain inhibitor in chronic progressive experimental autoimmune encephalomyelitis.	APP SCN8A	2.16e-05	2	162	2	18725211
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	RNF169 SETX RNGTT ATRX INTS7 ATP13A1 INTS1 DYRK1A ARHGEF12 APP IQGAP1 ORMDL1 UTP25 NFATC2 SUN2 RBM6 ANKRD17 EIF3A EIF3C PARD3	2.33e-05	1497	162	20	31527615
Pubmed	A probability-based approach for high-throughput protein phosphorylation analysis and site localization.	RNF169 SETX ZNF148 TRMT1 FCHO2 IQGAP1 EIF3CL RBM6 RACGAP1 EIF3C BAG6	2.61e-05	503	162	11	16964243
Pubmed	Kelch Domain of Gigaxonin Interacts with Intermediate Filament Proteins Affected in Giant Axonal Neuropathy.	DNHD1 SPTB ARHGEF12 ZZEF1 CEP72 EIF3A EIF3C	2.93e-05	187	162	7	26460568
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	TET2 DCHS2 CLSTN3 TRAF6 ATRX ATP13A1 SPTB SPTBN1 DYRK1A POGZ SEC31A REV3L APP FMNL2 IQGAP1 NFE2L3 EIF3C BRWD1	3.33e-05	1285	162	18	35914814
Pubmed	Menin and Menin-Associated Proteins Coregulate Cancer Energy Metabolism.	KIF13B ZNF148 INTS1 POGZ SRCAP PAF1 SUN2 EIF3C NUP188	3.42e-05	341	162	9	32971831
Pubmed	Mass spectrometry reveals modularity and a complete subunit interaction map of the eukaryotic translation factor eIF3.	EIF3CL EIF3A EIF3C	3.48e-05	14	162	3	18599441
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	TET2 SETX RNF44 XPO4 POGZ ZZEF1 IQGAP1 FBXL7 RACGAP1 ANKRD17 NUP188	4.12e-05	529	162	11	14621295
Pubmed	Interaction network of human early embryonic transcription factors.	TET2 ZNF131 ZNF148 POGZ APP RFX7 RESF1 ASXL3 CTNNB1	4.28e-05	351	162	9	38297188
Pubmed	Unbiased Identification of trans Regulators of ADAR and A-to-I RNA Editing.	SPTBN1 INTS1 POGZ DDX1 EIF3CL PRPF3 EIF3A EIF3C	4.30e-05	271	162	8	32433965
Pubmed	Structural characterization of the human eukaryotic initiation factor 3 protein complex by mass spectrometry.	EIF3CL EIF3A EIF3C	4.33e-05	15	162	3	17322308
Pubmed	Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.	RNGTT ATRX DYRK1A SRCAP UTP25 PRPF3 RBM6 ANKRD17 NUP188 CTNNB1	4.44e-05	440	162	10	34244565
Pubmed	Isolation and fine mapping of 16 novel human zinc finger-encoding cDNAs identify putative candidate genes for developmental and malignant disorders.	ZNF131 ZNF140 ZNF148	6.43e-05	17	162	3	7557990
Pubmed	A new spectrin, beta IV, has a major truncated isoform that associates with promyelocytic leukemia protein nuclear bodies and the nuclear matrix.	SPTB SPTBN1	6.45e-05	3	162	2	11294830
Pubmed	Amyloid precursor protein modulates Nav1.6 sodium channel currents through a Go-coupled JNK pathway.	APP SCN8A	6.45e-05	3	162	2	28008944
Pubmed	Comparative genomics and diversifying selection of the clustered vertebrate protocadherin genes.	FAT1 FAT2	6.45e-05	3	162	2	15744052
Pubmed	The mouse Jhy gene regulates ependymal cell differentiation and ciliogenesis.	CTNNB1 JHY	6.45e-05	3	162	2	29211732
Pubmed	The TET2/E-cadherin/β-catenin regulatory loop confers growth and invasion in hepatocellular carcinoma cells.	TET2 CTNNB1	6.45e-05	3	162	2	29331390
Pubmed	Chronic alcohol exposure promotes HCC stemness and metastasis through β-catenin/miR-22-3p/TET2 axis.	TET2 CTNNB1	6.45e-05	3	162	2	34019487
Pubmed	Suppression of the amyloidogenic metabolism of APP and the accumulation of Aβ by alcadein α in the brain during aging.	CLSTN3 APP	6.45e-05	3	162	2	39122814
Pubmed	TNFR-associated factor 6 and TGF-β-activated kinase 1 control signals for a senescence response by an endosomal NK cell receptor.	TRAF6 KIR2DL4	6.45e-05	3	162	2	24337384
Pubmed	β spectrin-dependent and domain specific mechanisms for Na+ channel clustering.	SPTB SPTBN1	6.45e-05	3	162	2	32425157
Pubmed	Kruppel-like factor 13 inhibits cell proliferation of gastric cancer by inducing autophagic degradation of β-catenin.	TRAF6 CTNNB1	6.45e-05	3	162	2	36336731
Pubmed	The aspartate-257 of presenilin 1 is indispensable for mouse development and production of beta-amyloid peptides through beta-catenin-independent mechanisms.	APP CTNNB1	6.45e-05	3	162	2	12070348
Pubmed	The kinase TNIK is an essential activator of Wnt target genes.	TNIK CTNNB1	6.45e-05	3	162	2	19816403
Pubmed	IQGAP1-mediated stimulation of transcriptional co-activation by beta-catenin is modulated by calmodulin.	IQGAP1 CTNNB1	6.45e-05	3	162	2	11734550
Pubmed	Stabilization of intracellular trafficking and metabolism of amyloid β-protein precursor and Alcadein β by apolipoprotein E.	CLSTN3 APP	6.45e-05	3	162	2	26213366
Pubmed	MicroRNA-34a targets FMNL2 and E2F5 and suppresses the progression of colorectal cancer.	E2F5 FMNL2	6.45e-05	3	162	2	26103003
Pubmed	The complete amino acid sequence for brain beta spectrin (beta fodrin): relationship to globin sequences.	SPTB SPTBN1	6.45e-05	3	162	2	8479293
Pubmed	Elucidation of the interaction of calmodulin with the IQ motifs of IQGAP1.	IQGAP1 CTNNB1	6.45e-05	3	162	2	12446675
Pubmed	β-Catenin/TCF4 Complex-Mediated Induction of the NRF3 (NFE2L3) Gene in Cancer Cells.	NFE2L3 CTNNB1	6.45e-05	3	162	2	31288376
Pubmed	Amyloidogenic processing of amyloid β protein precursor (APP) is enhanced in the brains of alcadein α-deficient mice.	CLSTN3 APP	6.45e-05	3	162	2	32467230
Pubmed	Developmental expression of brain beta-spectrin isoform messenger RNAs.	SPTB SPTBN1	6.45e-05	3	162	2	1467942
Pubmed	Fat1 interacts with Fat4 to regulate neural tube closure, neural progenitor proliferation and apical constriction during mouse brain development.	FAT1 CTNNB1 PARD3	7.69e-05	18	162	3	26209645
Pubmed	Requirement of FAT and DCHS protocadherins during hypothalamic-pituitary development.	DCHS2 FAT2 DCHS1	7.69e-05	18	162	3	33108146
Pubmed	Large-scale mapping of human protein-protein interactions by mass spectrometry.	DOCK4 KRT78 TRAF6 ATRX DYRK1A XPO4 IQGAP1 RGS20 PRPF3 SUN2 RACGAP1 EIF3A NUP188 CTNNB1 PARD3 CDC25B BAG6	1.10e-04	1284	162	17	17353931
Pubmed	Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.	MKRN4P PMS1 ZNF131 NR2E3 IKZF2 ZNF148 TFDP3 E2F5 POGZ SRCAP PAF1 CTNNB1 ZNF844	1.13e-04	808	162	13	20412781
Pubmed	Expanding the Interactome of TES by Exploiting TES Modules with Different Subcellular Localizations.	SPTBN1 APP PAF1 IQGAP1 ACAA2 CTNNB1 BAG6	1.23e-04	235	162	7	28378594
Pubmed	CIF-1, a shared subunit of the COP9/signalosome and eukaryotic initiation factor 3 complexes, regulates MEL-26 levels in the Caenorhabditis elegans embryo.	CSN1S1 EIF3A EIF3C	1.24e-04	21	162	3	17403899
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	PMS1 RNF169 RNGTT STXBP4 SPTBN1 XPO4 FCHO2 APP PAF1 PRPF3 CEP72 SUN2 EIF3C FBXO33 CDC25B	1.24e-04	1049	162	15	27880917
Pubmed	Human transcription factor protein interaction networks.	TET2 ZNF131 ZNF148 ATRX SPTBN1 POGZ SRCAP RFX7 DDX1 NOL4L FAT1 RESF1 RBM6 RACGAP1 ANKRD17 EIF3A HAGH EIF3C	1.28e-04	1429	162	18	35140242
Pubmed	RAGE regulates BACE1 and Abeta generation via NFAT1 activation in Alzheimer's disease animal model.	APP NFATC2	1.29e-04	4	162	2	19332646
Pubmed	Histone lysine methyltransferase Wolf-Hirschhorn syndrome candidate 1 is involved in human carcinogenesis through regulation of the Wnt pathway.	IQGAP1 CTNNB1	1.29e-04	4	162	2	22028615
Pubmed	Reversing EphB2 depletion rescues cognitive functions in Alzheimer model.	EPHB2 APP	1.29e-04	4	162	2	21113149
Pubmed	Dyrk1 inhibition improves Alzheimer's disease-like pathology.	DYRK1A APP	1.29e-04	4	162	2	28779511
Pubmed	TRAF6 functions as a tumor suppressor in myeloid malignancies by directly targeting MYC oncogenic activity.	TET2 TRAF6	1.29e-04	4	162	2	35045331
Pubmed	F-box protein FBXO16 functions as a tumor suppressor by attenuating nuclear β-catenin function.	FBXO16 CTNNB1	1.29e-04	4	162	2	30714168
Pubmed	Reduction of Tet2 exacerbates early stage Alzheimer's pathology and cognitive impairments in 2×Tg-AD mice.	TET2 APP	1.29e-04	4	162	2	31943063
Pubmed	Identification and characterization of novel human tissue-specific RFX transcription factors.	RFX7 RFX4	1.29e-04	4	162	2	18673564
Pubmed	Planar cell polarity-dependent asymmetric organization of microtubules for polarized positioning of the basal body in node cells.	DCHS2 DCHS1	1.29e-04	4	162	2	35420656
Interaction	TSPY8 interactions	TSPY3 TSPY2 TSPY8	5.00e-07	3	161	3	int:TSPY8
Interaction	RNF123 interactions	PMS1 SETX RNGTT PCDHB12 INTS1 OBSCN SLC28A3 REV3L APP ZZEF1 FMNL2 FBXL7 SCN8A CEP295 EIF3A NUP188 BAG6 ZNF582 ITPRIPL1 FBXO34	9.69e-06	824	161	20	int:RNF123
Interaction	SLX4 interactions	PMS1 RNF169 ATRX AFF3 DYRK1A POGZ REV3L APP PAF1 CREB5 POLR3F RESF1 PRPF3 RBM6 RACGAP1 NUP188	1.45e-05	572	161	16	int:SLX4
Interaction	POLR2F interactions	BDP1 SETX INTS7 INTS1 APP PAF1 POLR3F MED26	2.09e-05	144	161	8	int:POLR2F
Cytoband	Ensembl 112 genes in cytogenetic band chrYp11	TSPY3 TSPY2 TSPY8 TSPY1 CD99 TSPY10	1.65e-05	150	162	6	chrYp11
Cytoband	Yp11.2	TSPY3 TSPY2 TSPY8 TSPY1 TSPY10	2.19e-05	94	162	5	Yp11.2
GeneFamily	Cadherin related	DCHS2 CLSTN3 FAT1 FAT2 DCHS1	2.48e-08	17	98	5	24
GeneFamily	EF-hand domain containing\|Spectrins	SPTB SPTBN1	6.00e-04	7	98	2	1113
GeneFamily	Regulatory factor X family	RFX7 RFX4	7.97e-04	8	98	2	1153
GeneFamily	Cyclins\|F-boxes other	FBXO16 FBXO33 FBXO34	1.23e-03	39	98	3	560
GeneFamily	Eukaryotic translation initiation factor 3	EIF3A EIF3C	2.18e-03	13	98	2	1121
GeneFamily	Integrator complex	INTS7 INTS1	2.92e-03	15	98	2	1366
Coexpression	DACOSTA_UV_RESPONSE_VIA_ERCC3_DN	EPHB2 PMS1 DOCK4 SETX ZNF148 RNGTT ATRX DYRK1A E2F5 REV3L TRAPPC8 APP ZZEF1 CREB5 FAT1 RGS20 FBXL7 RBM6 ANKRD17 EIF3A PARD3	5.19e-08	856	158	21	M4500
Coexpression	DAZARD_RESPONSE_TO_UV_NHEK_DN	PMS1 DOCK4 ZNF148 ATRX DYRK1A E2F5 POGZ REV3L FAT1 FAT2 KANK1	2.23e-06	300	158	11	M8702
Coexpression	DACOSTA_UV_RESPONSE_VIA_ERCC3_COMMON_DN	PMS1 ZNF148 RNGTT ATRX DYRK1A REV3L TRAPPC8 FAT1 RGS20 FBXL7 RBM6 ANKRD17 PARD3	5.36e-06	466	158	13	M13522
Coexpression	LAKE_ADULT_KIDNEY_C22_ENDOTHELIAL_CELLS_GLOMERULAR_CAPILLARIES	DOCK4 SPTBN1 DYRK1A ARHGEF12 APP FMNL2 FBXL7	2.02e-05	137	158	7	M39241
Coexpression	GSE5542_UNTREATED_VS_IFNG_TREATED_EPITHELIAL_CELLS_24H_UP	TP53INP1 ARHGEF12 IQGAP1 PYHIN1 NFATC2 CD99 EIF3A ITPRIPL1	2.82e-05	198	158	8	M6522
Coexpression	ZAK_PBMC_MRKAD5_HIV_1_GAG_POL_NEF_AGE_20_50YO_1DY_DN	TNIK CLSTN3 IKZF2 TTC39C SPTBN1 AFF3 RFX7 PYHIN1 NOL4L NFATC2 PIK3C2B N4BP2 FGFBP2 SUN2 PLCL1 PRORP CDC25B BRWD1	4.14e-05	1012	158	18	M40864
Coexpression	LAKE_ADULT_KIDNEY_C2_PODOCYTES	DOCK4 TET2 ARHGEF12 FMNL2 FAT1 KANK1 FBXL7 PARD3	4.57e-05	212	158	8	M39221
CoexpressionAtlas	FacebaseRNAseq_e8.5_Floor Plate_top-relative-expression-ranked_2500_k-means-cluster#1	BDP1 SETX ATRX STXBP4 FCHO2 TRAPPC8 RFX7 ZNF250 UTP25 RBM6 EIF3A EIF3C PARD3 JHY	8.53e-06	469	154	14	Facebase_RNAseq_e8.5_Floor Plate_2500_K1
ToppCell	COVID-19-COVID-19_Mild-Lymphocyte-T/NK-NK_activated\|COVID-19_Mild / Disease, condition lineage and cell class	CLSTN3 IKZF2 SETX ARHGEF12 SRCAP EIF3CL PYHIN1 NFATC2 FGFBP2 EIF3C	3.46e-09	200	162	10	2281debd86e5d92e8fe0397aec9ef670800f7471
ToppCell	COVID_non-vent-Lymphocytic\|COVID_non-vent / Disease condition, Lineage, Cell class and subclass	TNIK IKZF2 SPTBN1 PYHIN1 ORMDL3 RESF1 NFATC2 FGFBP2 CDC25B	4.67e-08	197	162	9	c672915f8c8c1e948d251f6eaf9f84a5600c1193
ToppCell	Bronchial-NucSeq\|Bronchial / Cell types per location group and 10X technology with lineage, and cell group designations	DOCK4 LRRC37A3 AFF3 DYRK1A ZNF407 RFX7 KANK1 PARD3	6.26e-07	196	162	8	ab53c742866945545a92e2e61850d63c80d9a2a6
ToppCell	T_cells\|World / Immune cells in Kidney/Urine in Lupus Nephritis	TNIK IKZF2 PYHIN1 RESF1 NFATC2 CD99 FGFBP2 SUN2	6.76e-07	198	162	8	1ca6cd8e75891fdfaddbb4a7342eec9ca4d11e5d
ToppCell	healthy_donor-Lymphocytic\|healthy_donor / Disease condition, Lineage, Cell class and subclass	TNIK SPTBN1 PYHIN1 ORMDL3 RESF1 NFATC2 FGFBP2 CDC25B	7.02e-07	199	162	8	2841e16d54acd344ba454f024e285c28abc37319
ToppCell	Tracheal-NucSeq\|Tracheal / Cell types per location group and 10X technology with lineage, and cell group designations	LRRC37A3 AFF3 DYRK1A ZNF407 RFX7 FMNL2 RBM6 PARD3	7.02e-07	199	162	8	94b94b17ca18b8dc27b91da1f2ccf89e03cc7035
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW10-Macroglial-Astrocyte\|GW10 / Sample Type, Dataset, Time_group, and Cell type.	ZNF407 NEB RFX4 RGS20 KIAA1549L UTP25 FGFBP2 CDADC1	7.29e-07	200	162	8	98a994692440cb4f505b050276f0c8022c814a21
ToppCell	LPS_IL1RA_TNF-Endothelial-Endothelial-Alv_Cap\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	SETX SPTBN1 AFF3 ARHGEF12 APP RESF1 CD99 ARHGAP27	7.29e-07	200	162	8	b7533c571eeea0cb3678e1a57d3dc036fa8d0f49
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW10-Macroglial\|GW10 / Sample Type, Dataset, Time_group, and Cell type.	ZNF407 NEB RFX4 RGS20 KIAA1549L UTP25 FGFBP2 CDADC1	7.29e-07	200	162	8	ef222dc4a205d670172dae74990bdb952ac92e5b
ToppCell	LPS_only-Endothelial-Endothelial-Alv_Cap\|LPS_only / Treatment groups by lineage, cell group, cell type	SETX SPTBN1 AFF3 ARHGEF12 FCHO2 APP RESF1 LRRC36	7.29e-07	200	162	8	432384faeade8e609154fab3d96c955a8ec868dd
ToppCell	droplet-Lung-nan-3m-Lymphocytic-Regulatory_T\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TNIK PHLDB3 IKZF2 RNGTT SLC28A3 NEB CDC25B	2.80e-06	168	162	7	1df3c8c7a6dceb901805eaba7f86f9943f4f1a9d
ToppCell	droplet-Lung-nan-3m-Lymphocytic-regulatory_T_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TNIK PHLDB3 IKZF2 RNGTT SLC28A3 NEB CDC25B	2.80e-06	168	162	7	1586451d437b70b2dffe41d782b694702dcaf50b
ToppCell	normal_Lymph_Node-B_lymphocytes-GrB-secreting_B_cells\|normal_Lymph_Node / Location, Cell class and cell subclass	ZFAT LRRC37A3 APP FBXO16 LRRC37A ARHGAP27 LRRC36	3.67e-06	175	162	7	29fbdfe1d3bfcb063be2bced0128a33176c5b78f
ToppCell	PND10-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_T-Treg-Treg_G2M\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	IKZF2 NEB PYHIN1 NFATC2 SLC9B2 RACGAP1 CDC25B	3.67e-06	175	162	7	9de288c338cee67be0e9b836c87799bbc1db1c38
ToppCell	droplet-Marrow-nan-3m\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SETX ATRX SPTBN1 FCHO2 IQGAP1 PYHIN1 EIF3A	5.10e-06	184	162	7	1154a5ad7b8512272b7476f949ddac350910bfb7
ToppCell	PBMC-Mild-Lymphocyte-T/NK-CD4+_T-Treg\|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)	TNIK IKZF2 TTC39C PYHIN1 RESF1 PLCL1 CDC25B	5.87e-06	188	162	7	72be6fe654f3a5f654d3b9680145bce7ae9b721d
ToppCell	COVID-19_Mild-Lymphoid_T/NK-Treg\|COVID-19_Mild / Disease group, lineage and cell class	TNIK IKZF2 TTC39C PYHIN1 RESF1 PLCL1 CDC25B	5.87e-06	188	162	7	42553fdc127e5f613ffd5067620a768a40f1a8a1
ToppCell	droplet-Large_Intestine-COLON_PROXIMAL-30m-Epithelial\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZNF148 ATRX SPTBN1 IQGAP1 RNASEL EIF3C CTNNB1	6.51e-06	191	162	7	09db184cb90fe282a14474d7217068c58092c6f8
ToppCell	facs-Skin-Anagen-3m-Epithelial-bulge_keratinocyte\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TTC39C APP CREB5 KANK1 SUN2 CTNNB1 ITPRIPL1	6.97e-06	193	162	7	eba3c70701b051bc1ed1f4db9270cb27a77ffc3e
ToppCell	healthy_donor-Lymphocytic-T_cell-CD8+_Memory_T_cell\|healthy_donor / Disease condition, Lineage, Cell class and subclass	PYHIN1 RESF1 NFATC2 CD99 FGFBP2 SUN2 CDC25B	7.71e-06	196	162	7	af00c31612e4fe068e5fccae05368edba46bbd20
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Lymphoid-CD4/CD8-CD8_EM-F\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	PMS1 BDP1 LRRC37A3 XPO4 RFX4 LRGUK RGS20	7.71e-06	196	162	7	7e98380d815fbf6254289ace2af37aac6fef51e8
ToppCell	facs-Trachea-3m\|Trachea / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	SPTBN1 ARHGEF12 SEC31A APP SUN2 CTNNB1 GAA	7.97e-06	197	162	7	e77016d64b1cac9825fec7cfe5071f1567401187
ToppCell	facs-Trachea-nan-3m\|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SPTBN1 ARHGEF12 SEC31A APP SUN2 CTNNB1 GAA	7.97e-06	197	162	7	0353d925ee4b7aefc2c51b5fab873f465cdf9ebc
ToppCell	Parenchymal-NucSeq\|Parenchymal / Cell types per location group and 10X technology with lineage, and cell group designations	DOCK4 LRRC37A3 AFF3 DYRK1A ZNF407 KANK1 PARD3	8.24e-06	198	162	7	1996373bdccc55aac347d349bd22f6aad6d0c668
ToppCell	LPS_IL1RA-Endothelial-Endothelial-Gen_Cap\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	SETX ATRX SPTBN1 ARHGEF12 APP RESF1 BRWD1	8.79e-06	200	162	7	dccec522ab0d7fff62ad6273b02aa9022dbbb8eb
ToppCell	mild-CD8+_Tem\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	TNIK ATRX PYHIN1 RESF1 NFATC2 CD99 FGFBP2	8.79e-06	200	162	7	d8aec4904c9420b8f9d7508658ba1e36c66cdfcc
ToppCell	LPS_anti-TNF-Endothelial-Endothelial-Activated_Alv_Cap\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	SETX SPTBN1 AFF3 ARHGEF12 FCHO2 APP RESF1	8.79e-06	200	162	7	bcd1cc96197929d6011903803b6f4ccdcf52b4ce
ToppCell	mLN-Macrophage-LYVE1_Macrophage\|Macrophage / Region, Cell class and subclass	ATP13A1 APP IQGAP1 ORMDL1 RESF1 RBM6 HAGH	8.79e-06	200	162	7	e3c15e0e1c2602b0cc9ab8cc50c978d265350c94
ToppCell	COVID-19-COVID-19_Mild-Lymphocyte-T/NK-Treg\|COVID-19_Mild / Disease, condition lineage and cell class	TNIK IKZF2 TTC39C PYHIN1 RESF1 PLCL1 CDC25B	8.79e-06	200	162	7	c6ae15f7deba26008af5b647855675003bb2ebcd
ToppCell	Control-Lymphoid_T/NK\|Control / Disease group, lineage and cell class	TNIK PYHIN1 NFATC2 CD99 FGFBP2 SUN2 CDC25B	8.79e-06	200	162	7	b5d5eead192a22c6b5ea699fe36873809fe6e3e2
ToppCell	Sepsis-Bac-SEP-Lymphocyte-T/NK-NK\|Bac-SEP / Disease, condition lineage and cell class	PYHIN1 NFATC2 CD99 FGFBP2 SUN2 ACAA2 KIR2DL4	8.79e-06	200	162	7	394ec91eb3eafde313d67abc986095799ab4e6ac
ToppCell	Sepsis-Leuk-UTI-Lymphocyte-T/NK-CD8+_Tem\|Leuk-UTI / Disease, condition lineage and cell class	PYHIN1 ORMDL3 NFATC2 CD99 FGFBP2 CDC25B ITPRIPL1	8.79e-06	200	162	7	aa8104dcb2ba5756a23c25a580bef2360ff25b13
ToppCell	Transplant_Alveoli_and_parenchyma-Epithelial-Ciliated_2\|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X	PMS1 DNHD1 ZFAT IKZF2 RPP38-DT DCUN1D2	2.66e-05	160	162	6	6de505bfe1fbbe984718740a9cf43d0e02ff452e
ToppCell	5'-Adult-Appendix-Hematopoietic-T_cells-MAIT_cell\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	IKZF2 TTC39C EIF3CL PYHIN1 CCDC157 JHY	3.28e-05	166	162	6	e4f14b2dd8c6199fa27cc3e3beeda681a3b5b889
ToppCell	COVID-pDC\|COVID / Condition, Cell_class and T cell subcluster	ZFAT AFF3 E2F5 APP FBXO16 LRRC36	4.00e-05	172	162	6	3ecbb000495dde32f6153ef6bdea9c8802ff3985
ToppCell	COVID-pDC-\|COVID / Condition, Cell_class and T cell subcluster	ZFAT AFF3 E2F5 APP FBXO16 LRRC36	4.00e-05	172	162	6	a7827faa1afab51fdaf0cb1a2babcd2e00d411e5
ToppCell	systemic_lupus_erythematosus-flare-Lymphocytic_B-B_cell-male\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	ZFAT OBSCN E2F5 FMNL2 SLC9B2 ZNF582	4.40e-05	175	162	6	69ed3c7c45df6bef70f5f2ff003531160bf3b32b
ToppCell	LPS_only-Lymphocytic_NKT-iNKT/MAIT\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	TNIK IKZF2 TTC39C PYHIN1 NFATC2 KIR2DL4	4.99e-05	179	162	6	de3ddc1264e43727be50d69b81cc84a3c91812a2
ToppCell	LPS_only-Lymphocytic_NKT-iNKT/MAIT-iNKT-MAIT\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	TNIK IKZF2 TTC39C PYHIN1 NFATC2 KIR2DL4	4.99e-05	179	162	6	def981e97e3ff9019910c9af3861ca0d08eb0d0f
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell_\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	DOCK4 SPTBN1 VWA1 FBXL7 PIK3C2B DCHS1	4.99e-05	179	162	6	8f9e538c822940785130297712b75131812a4603
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c08-IL2RB\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	BDP1 CLSTN3 E2F5 ZZEF1 CDADC1 KIR2DL4	4.99e-05	179	162	6	db76edd368eeca05a2a5d407c3eb2f535ade0ce3
ToppCell	Fetal_29-31_weeks-Mesenchymal-myofibroblast_cell-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	NR2E3 REV3L FMNL2 CREB5 FAT1 NFATC2	5.47e-05	182	162	6	ed6ae0fd8653f213fe29906a6a4e0729a62e1b75
ToppCell	CF-Lymphoid-T_cell_&_NK_cell\|CF / Disease state, Lineage and Cell class	TNIK TTC39C RFX7 PYHIN1 NFATC2 FGFBP2	5.47e-05	182	162	6	a8dfc59a3974e3433f434676b7c2749d0fcfc8b2
ToppCell	PBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c12-FOXP3\|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)	TNIK IKZF2 TTC39C PYHIN1 PLCL1 CDC25B	5.81e-05	184	162	6	08bff25390e3484b75c860738396a405141b69fd
ToppCell	TCGA-Pancreas-Primary_Tumor-Pancreatic_Adenocarcinoma-Ductal_Adenocarcinoma-1\|TCGA-Pancreas / Sample_Type by Project: Shred V9	TNIK SETX ATRX ARHGEF12 RESF1 CEP295	6.17e-05	186	162	6	03db813598b67b1e08f759758a1c2023396921fa
ToppCell	368C-Lymphocytic-NK_cells-NK_cell_D3\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	KIF13B LRRC37A3 DYRK1A POLR3F CLCN3 KIR2DL4	6.36e-05	187	162	6	c667fae6440dc98072b584f203d00f0fb1cb2f21
ToppCell	368C-Lymphocytic-NK_cells-NK_cell_D3\|368C / Donor, Lineage, Cell class and subclass (all cells)	KIF13B TRAF6 LRRC37A3 DYRK1A POLR3F KIR2DL4	6.55e-05	188	162	6	ecc2364d946f97ae0212fd6739960c9fc75e4919
ToppCell	PBMC-Mild-Lymphocyte-T/NK-CD4+_T-Treg\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	TNIK IKZF2 TTC39C RESF1 PLCL1 CDC25B	6.55e-05	188	162	6	9db3d3010cb8a1f3ee1cdccaf3cbaac3cf983fc5
ToppCell	LPS_only-Lymphocytic_NKT\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	TNIK IKZF2 TTC39C PYHIN1 NFATC2 PLCL1	6.55e-05	188	162	6	bbe65b1c11c88ab62d8485cfc3a913ff9da89aad
ToppCell	Control-Lymphoid-NK\|World / Disease state, Lineage and Cell class	PYHIN1 ZNF250 NOL4L NFATC2 FGFBP2 KIR2DL4	6.74e-05	189	162	6	89ef0d0e66dc96cacaae6be7aacdaa884e8e66a8
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-24m-Neuronal-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CLSTN3 SPTB CHGB FAT2 SPHKAP SCN8A	6.74e-05	189	162	6	f57200c93d39c9bce1adba0a6a1c178c028dd86b
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c03-ITGA4\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	TNIK TP53INP1 SPTBN1 PYHIN1 CDC25B FBXO34	6.94e-05	190	162	6	91ba66d4b56c59523485b17738e93f14bb00afa4
ToppCell	Children_(3_yrs)-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	DCHS2 SPTBN1 AFF3 OBSCN APP NMD3	6.94e-05	190	162	6	0a351609a72fd638c84b2435782e312ee6a33aac
ToppCell	Bac-SEP-Lymphocyte-T_NK-gdT\|Bac-SEP / Disease, Lineage and Cell Type	PHLDB3 PYHIN1 CD99 FGFBP2 SUN2 CDC25B	6.94e-05	190	162	6	c7c5bc50082b2243cae8eb04784d03f14a739b3b
ToppCell	Control-Lymphoid-NK\|Control / Disease state, Lineage and Cell class	PYHIN1 ZNF250 NOL4L NFATC2 FGFBP2 KIR2DL4	6.94e-05	190	162	6	f7bd8521a40ac30a64dc439f17e2f6c7d021ef65
ToppCell	droplet-Large_Intestine-COLON_PROXIMAL\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZNF148 ATRX SPTBN1 IQGAP1 RNASEL EIF3C	7.15e-05	191	162	6	60c986d2dcbc19d9338c03da6cb5e1d92fd48f8e
ToppCell	droplet-Large_Intestine-COLON_PROXIMAL-30m\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZNF148 ATRX SPTBN1 IQGAP1 RNASEL EIF3C	7.15e-05	191	162	6	973117730d6ba5f127e7a0bfabfd0ff2ca7ac131
ToppCell	Leuk-UTI-Lymphocyte-T_NK-CD8_TEM\|Leuk-UTI / Disease, Lineage and Cell Type	PYHIN1 ORMDL3 NFATC2 CD99 FGFBP2 CDC25B	7.35e-05	192	162	6	2787b52546eedada4aa413025b86841c351273f4
ToppCell	3'-Pediatric_IBD-SmallIntestine-Hematopoietic-T_cells-CD8_Tmem\|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PYHIN1 RESF1 NFATC2 CD99 FGFBP2 SUN2	7.57e-05	193	162	6	53b3f9a8967541ca817a250439a7928d36b45386
ToppCell	Bac-SEP-Lymphocyte-T_NK-NK\|Bac-SEP / Disease, Lineage and Cell Type	PYHIN1 NFATC2 CD99 FGFBP2 SUN2 KIR2DL4	7.57e-05	193	162	6	8aa4ed2b11c6189d86e7de6bc68782fd156a37fb
ToppCell	CF-Lymphoid\|CF / Disease state, Lineage and Cell class	TTC39C AFF3 E2F5 RFX7 PYHIN1 NFATC2	7.57e-05	193	162	6	11de07d13a7da223990b56fa89ba7fc1c3dd0122
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-24m-Neuronal\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CLSTN3 SPTB CHGB FAT2 SPHKAP SCN8A	7.57e-05	193	162	6	5fb7808dd971c1cc64c2bd4f8f1de646fb2d77f4
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	DOCK4 SPTBN1 VWA1 APP FBXL7 PIK3C2B	7.79e-05	194	162	6	74a9fdb73f279bebb6337510deab9aaaf9f7e957
ToppCell	facs-Skin-Anagen-3m-Epithelial-outer_bulge\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TTC39C APP KANK1 SUN2 CTNNB1 ITPRIPL1	7.79e-05	194	162	6	5d30d3d41d5f19cdf3077cc609aa2738762cb8c5
ToppCell	PBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c05-ZNF683\|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)	TNIK PYHIN1 NFATC2 CD99 FGFBP2 CDC25B	8.24e-05	196	162	6	51c750a0fb2b87e17e62b984c91fb16f676d7e76
ToppCell	10x5'-bone_marrow-Lymphocytic_T_CD8-Tem/emra_CD8\|bone_marrow / Manually curated celltypes from each tissue	PYHIN1 NFATC2 CD99 FGFBP2 SUN2 CDC25B	8.24e-05	196	162	6	f23c33ad10f933250be98e8389a9aa278e876f96
ToppCell	10x3'2.3-week_17-19-Hematopoietic-erythroid-mid_erythroid\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	SPTB ARHGEF12 HMBS FCHO2 CLCN3 HAGH	8.24e-05	196	162	6	51c48944149a89b98011a50fe81ca6664d5f0d44
ToppCell	10x3'2.3-week_17-19-Hematopoietic\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	SPTB ARHGEF12 HMBS FCHO2 CLCN3 HAGH	8.24e-05	196	162	6	2aeb792e7685e33e3543a6974be790980a41ed8c
ToppCell	facs-Limb_Muscle-ForelimbandHindlimb-3m\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SPTBN1 ARHGEF12 SEC31A APP EIF3A CTNNB1	8.24e-05	196	162	6	151f1a29a91f8b234e9b6ed062666357a2f69128
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell\|Severe-critical_progression_d12-22 / Compartment, severity and other cell annotations on 10x 3' data (130k)	TNIK PYHIN1 NOL4L NFATC2 CD99 FGFBP2	8.24e-05	196	162	6	a2db88fad9bbc55685f8e681d120ef38715ca3c4
ToppCell	10x5'-bone_marrow-Lymphocytic_NK-NK_CD16\|bone_marrow / Manually curated celltypes from each tissue	PYHIN1 NFATC2 CD99 FGFBP2 SUN2 KIR2DL4	8.24e-05	196	162	6	a3b077e82b1550eb328c84b567b60179001f9a77
ToppCell	10x5'-bone_marrow-Lymphocytic_NK\|bone_marrow / Manually curated celltypes from each tissue	PYHIN1 NFATC2 CD99 FGFBP2 SUN2 KIR2DL4	8.24e-05	196	162	6	1868ad537b7f04cdad0a0c8282aadbc4f257a722
ToppCell	COVID_non-vent-Lymphocytic-T_cell-CD8+_Memory_T_cell\|COVID_non-vent / Disease condition, Lineage, Cell class and subclass	IKZF2 PYHIN1 RESF1 NFATC2 FGFBP2 CDC25B	8.47e-05	197	162	6	836061acd7f0d5de89b16f52ec679bdf09eac9db
ToppCell	10x5'-Lung-Lymphocytic_T_CD8-Tem/emra_CD8\|Lung / Manually curated celltypes from each tissue	PYHIN1 ORMDL3 NFATC2 FGFBP2 SUN2 CDC25B	8.47e-05	197	162	6	a573a59e2271f5d0ce5de0b851951ab72659e060
ToppCell	10x3'2.3-week_17-19-Hematopoietic-erythroid\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	SPTB ARHGEF12 HMBS FCHO2 CLCN3 HAGH	8.47e-05	197	162	6	b71da7f2fd8d526fb6e5d57e60fc08acdd8dbefb
ToppCell	PBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c05-ZNF683\|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)	IKZF2 PYHIN1 NFATC2 CD99 FGFBP2 CDC25B	8.47e-05	197	162	6	ff34be81ee77efe60618641fa7c1084442b991d7
ToppCell	PBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell\|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)	TNIK IKZF2 PYHIN1 NFATC2 CD99 FGFBP2	8.47e-05	197	162	6	a44501cac24c2f4a53b413e92bd060eed6514616
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	TNIK PYHIN1 NOL4L FGFBP2 SUN2 KIR2DL4	8.47e-05	197	162	6	32b770e403028862f91e4727f4a8fbb6151910e4
ToppCell	severe-Lymphocytic-NK_cells\|severe / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	IKZF2 PYHIN1 NFATC2 FGFBP2 SUN2 KIR2DL4	8.47e-05	197	162	6	8bf88b10d49ac499e7d0ba5b7023909e1fd7b29a
ToppCell	mild-Treg\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	TNIK IKZF2 TTC39C PYHIN1 RESF1 PLCL1	8.47e-05	197	162	6	39800e6e83f2d333b753d121c7aeb2912b91faa2
ToppCell	390C-Lymphocytic-NK_cells-NK_cell_B\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	PYHIN1 CD99 FGFBP2 SUN2 ACAA2 KIR2DL4	8.47e-05	197	162	6	d2f7ba404a0340e12ccbd3f9d76c8d782584e775
ToppCell	Healthy-CD8+_Tem\|Healthy / disease group, cell group and cell class	PYHIN1 ORMDL3 CD99 FGFBP2 SUN2 CDC25B	8.47e-05	197	162	6	8d60fdd5ce80c3496637fd3257d25258df6d7f75
ToppCell	PBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell\|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)	TNIK PYHIN1 NFATC2 CD99 FGFBP2 CDC25B	8.47e-05	197	162	6	35004d4728d33f15cc3be99a073b1ea965365c32
ToppCell	T_cells-CTLs\|World / Immune cells in Kidney/Urine in Lupus Nephritis	PYHIN1 NFATC2 CD99 FGFBP2 SUN2 CDC25B	8.47e-05	197	162	6	2de34e20915a247bee75aa40495e23c20bb23e18
ToppCell	COVID-CD4-exh_CD4\|COVID / Condition, Cell_class and T cell subcluster	CLSTN3 SPTBN1 PYHIN1 RESF1 CD99 SUN2	8.47e-05	197	162	6	39ee4b93625c994813044d8dd8854fba2bd99940
ToppCell	Severe_COVID-19-T/NK-CD8+_T\|Severe_COVID-19 / Disease group,lineage and cell class （2021.01.30）	CLSTN3 PYHIN1 RESF1 NFATC2 CD99 FGFBP2	8.71e-05	198	162	6	584f0dc6f22bb13956a5f6950698599e382907e9
ToppCell	healthy_donor-Lymphocytic-ILC-NK_cell\|healthy_donor / Disease condition, Lineage, Cell class and subclass	IKZF2 ARHGEF12 IQGAP1 PYHIN1 NFATC2 FGFBP2	8.71e-05	198	162	6	d7053a898e04478c577381085f615edaad3cdc5b
ToppCell	facs-Tongue-nan-3m-Epithelial\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SPTBN1 ARHGEF12 SEC31A APP IQGAP1 CTNNB1	8.71e-05	198	162	6	2f03f8897dd7cce6d8296638e14e11ec16bcf624
ToppCell	mild-Lymphocytic-NK_cells\|mild / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	CLSTN3 PYHIN1 NFATC2 FGFBP2 SUN2 KIR2DL4	8.71e-05	198	162	6	dce3c008757786aa6bd4a869456b76b4cbbb1d5b
ToppCell	mild_COVID-19_(asymptomatic)-NK\|mild_COVID-19_(asymptomatic) / disease group, cell group and cell class (v2)	TNIK EPG5 PYHIN1 NFATC2 FGFBP2 SUN2	8.71e-05	198	162	6	1e43181c13e054570046c7a973ddc1c586e259b0
ToppCell	BAL-Severe-Lymphocyte-T/NK-CD8+_T-CD8+_T-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	CLSTN3 PYHIN1 RESF1 NFATC2 CD99 FGFBP2	8.71e-05	198	162	6	2eb80255bacddbf778b1c9eec09f74b4cdb09b36
ToppCell	COVID-19-lung-Capillary_2\|COVID-19 / Disease (COVID-19 only), tissue and cell type	DOCK4 SPTBN1 AFF3 FBXL7 PIK3C2B CDC25B	8.71e-05	198	162	6	45419f2804b4be79bae6632e71c54e1af482d115
ToppCell	BAL-Severe-Lymphocyte-T/NK-CD8+_T\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	CLSTN3 PYHIN1 RESF1 NFATC2 CD99 FGFBP2	8.71e-05	198	162	6	ec99da4e269c4cd982a395cdac0e4487ab14ec39
ToppCell	healthy_donor-Lymphocytic-ILC\|healthy_donor / Disease condition, Lineage, Cell class and subclass	IKZF2 ARHGEF12 IQGAP1 PYHIN1 NFATC2 FGFBP2	8.71e-05	198	162	6	aa33be29e26f1b8facfc894413099083ae3bbb1b
ToppCell	facs-Tongue-nan-3m\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SPTBN1 ARHGEF12 SEC31A APP IQGAP1 CTNNB1	8.71e-05	198	162	6	f2a4057f038ef7225a5b98a7ab068c30dff4eadd
ToppCell	Healthy_donor-gd_T\|World / disease group, cell group and cell class (v2)	TNIK PYHIN1 ORMDL3 CD99 FGFBP2 SUN2	8.71e-05	198	162	6	0c3475936f148f2c026501c61b43bcb94d320c48
ToppCell	BAL-Severe-Lymphocyte-T/NK-CD8+_T-CD8+_T\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	CLSTN3 PYHIN1 RESF1 NFATC2 CD99 FGFBP2	8.71e-05	198	162	6	06fdf8554148d11c0a946a7fd200edd9fa7e1965
ToppCell	mild-low-quality_cells\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	TNIK BDP1 IKZF2 ATRX ZNF407 PYHIN1	8.96e-05	199	162	6	f0b0097df0026496470a80d8cc9375ffd8389b00
ToppCell	facs-Tongue-nan-3m-Epithelial-nan\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ATRX SPTBN1 ARHGEF12 APP IQGAP1 CTNNB1	8.96e-05	199	162	6	8d50e1ee58710d896c0204937331d9f4dcd38de0
ToppCell	COPD-Myeloid-Macrophage\|Myeloid / Disease state, Lineage and Cell class	DOCK4 TET2 KIF13B APP CREB5 CD99	8.96e-05	199	162	6	1cf1b2d6debf9e3389f1829dcaa2857e9533a080
Disease	Neurodevelopmental Disorders	DYRK1A POGZ SRCAP ASXL3 SCN8A CTNNB1	7.96e-06	93	149	6	C1535926
Disease	reaction time measurement	TNIK TET2 ZFAT ATP13A1 LRRC37A2 SLC28A3 CADM2 KIAA1549L UTP25 CEP72 N4BP2 CDH7	1.35e-04	658	149	12	EFO_0008393
Disease	spinocerebellar ataxia type 5 (implicated_via_orthology)	SPTB SPTBN1	1.51e-04	4	149	2	DOID:0050882 (implicated_via_orthology)
Disease	chronotype measurement	ZFAT RFX4 CADM2 NMD3 NOL4L KANK1 RNASEL PRPF3 SCN8A DCHS1 RBM6 PLCL1 FBXO33 JHY	1.60e-04	882	149	14	EFO_0008328
Disease	age at menarche	TET2 ZNF131 STXBP4 ADCK1 AFF3 SLC28A3 RBM6 PLCL1 FBXO33 JHY BRWD1	2.27e-04	594	149	11	EFO_0004703
Disease	schizophrenia, intelligence, self reported educational attainment	TET2 AFF3 ITIH1 CADM2 SPHKAP RBM6 PLCL1 MED26	3.92e-04	346	149	8	EFO_0004337, EFO_0004784, MONDO_0005090
Disease	open-angle glaucoma	ARHGEF12 APP FMNL2 ITIH1 CADM2 IQGAP1	4.34e-04	191	149	6	EFO_0004190
Disease	cognitive function measurement, self reported educational attainment	AFF3 ITIH1 CADM2 EIF3CL NOL4L PLCL1 EIF3C FBXO33	4.64e-04	355	149	8	EFO_0004784, EFO_0008354
Disease	presubiculum volume	TNIK REV3L PLCL1	5.11e-04	31	149	3	EFO_0009400
Disease	prostate-specific antigen measurement, disease progression measurement	SPHKAP ACAA2	5.23e-04	7	149	2	EFO_0008336, EFO_0020660
Disease	folding of antihelix	DCHS2 CREB5	5.23e-04	7	149	2	EFO_0007671
Disease	age at initiation of corrective lens use	RFX4 BRWD1	6.95e-04	8	149	2	EFO_0021781
Disease	asthma (implicated_via_orthology)	ORMDL1 ORMDL3 ORMDL2	7.34e-04	35	149	3	DOID:2841 (implicated_via_orthology)
Disease	beverage consumption measurement	DOCK4 INTS7 CADM2 PLCL1	8.42e-04	83	149	4	EFO_0010088
Disease	asparaginase-induced acute pancreatitis	NEB C3orf20	8.91e-04	9	149	2	EFO_1001507
Disease	sun exposure measurement	CADM2 PLCL1	8.91e-04	9	149	2	EFO_0010729
Disease	attention deficit hyperactivity disorder, autism spectrum disorder, intelligence	TET2 AFF3 CADM2 RBM6 PLCL1 FBXO33 CTNNB1 BRWD1	9.75e-04	398	149	8	EFO_0003756, EFO_0003888, EFO_0004337
Disease	platelet crit	TET2 ATRX ATP13A1 STXBP4 AFF3 ARHGEF12 ZNF407 EPG5 NOL4L PRPF3 DCHS1 EIF3A GAA	1.12e-03	952	149	13	EFO_0007985
Disease	memory performance	ZFAT ARHGEF12 NEB ITIH1 ZNF250 KIAA1549L N4BP2 FBXO33	1.16e-03	409	149	8	EFO_0004874
Disease	Parkinson disease	DYRK1A RFX4 ITIH1 RESF1 CLCN3 ASXL3 ARHGAP27	1.27e-03	321	149	7	MONDO_0005180
Disease	subiculum volume	TNIK SPTBN1 PLCL1	1.34e-03	43	149	3	EFO_0009399
Disease	waist-hip ratio	EPHB2 TET2 ZFAT AFF3 HMBS ZNF407 SLC28A3 RFX7 ZZEF1 RFX4 CADM2 PIK3C2B CDADC1 RBM6 LRRC36	1.41e-03	1226	149	15	EFO_0004343
Disease	circadian rhythm	NMD3 RNASEL SCN8A PLCL1 FBXO34	1.46e-03	163	149	5	EFO_0004354
Disease	corpus callosum volume measurement	TNIK TTC39C FBXL7 RBM6	1.68e-03	100	149	4	EFO_0010299
Disease	Weight Gain	SPTBN1 ARHGEF12 APP IQGAP1	1.81e-03	102	149	4	C0043094
Disease	DNA methylation	DNHD1 DCHS2 ZFAT IKZF2 RNGTT CREB5 RESF1 DCHS1 PARD3 JHY	1.90e-03	656	149	10	GO_0006306
Disease	level of Sphingomyelin (d34:2) in blood serum	ANKRD17 RIC1	1.90e-03	13	149	2	OBA_2045174
Disease	cholesterol to total lipids in small HDL percentage	APOA5 NFE2L3 ACAA2	2.20e-03	51	149	3	EFO_0022240
Disease	serum gamma-glutamyl transferase measurement	TNIK KRT78 IKZF2 TP53INP1 ATRX DYRK1A SLC28A3 CREB5 NFE2L3 LRGUK ORMDL3 PARD3	2.39e-03	914	149	12	EFO_0004532
Disease	mean reticulocyte volume	ZFAT STXBP4 SPTB AFF3 DYRK1A NEB NOL4L RESF1 RBM6 CDC25B BAG6	2.52e-03	799	149	11	EFO_0010701
Disease	autism spectrum disorder (is_implicated_in)	DYRK1A CADM2	2.90e-03	16	149	2	DOID:0060041 (is_implicated_in)
Disease	omega-3 polyunsaturated fatty acid measurement	APOA5 NFE2L3 ACAA2 BRWD1	3.07e-03	118	149	4	EFO_0010119
Disease	asthma, Eczema, allergic rhinitis	IQGAP1 NFATC2 PLCL1 ARHGAP27	3.36e-03	121	149	4	EFO_0005854, HP_0000964, MONDO_0004979
Disease	behavior or behavioral disorder measurement, personality trait	INTS7 BRWD1	3.67e-03	18	149	2	EFO_0004365, EFO_0004782
Disease	serum IgG measurement	AFF3 FCHO2	3.67e-03	18	149	2	EFO_0004565
Disease	Malignant neoplasm of endometrium	PMS1 CTNNB1	3.67e-03	18	149	2	C0007103
Disease	Carcinoma in situ of endometrium	PMS1 CTNNB1	3.67e-03	18	149	2	C0346191
Disease	puberty onset measurement	SLC28A3 PLCL1 JHY BRWD1	3.77e-03	125	149	4	EFO_0005677
Disease	Astigmatism	DOCK4 AFF3 FMNL2 PLCL1	4.22e-03	129	149	4	HP_0000483
Disease	Tinnitus	KRT78 SPTBN1 CADM2 NFATC2	4.34e-03	130	149	4	HP_0000360
Disease	free cholesterol:total lipids ratio, high density lipoprotein cholesterol measurement	APOA5 HMBS NFE2L3 SCN8A RBM6 ACAA2	4.50e-03	303	149	6	EFO_0004612, EFO_0020945
Disease	household income	TET2 AFF3 CADM2 PIK3C2B RBM6 PLCL1	4.57e-03	304	149	6	EFO_0009695
Disease	body weight	TET2 ZFAT STXBP4 SPATA31C2 ARHGEF12 SLC28A3 ZZEF1 CADM2 NOL4L NFATC2 ASXL3 SPHKAP PLCL1 CDH7	4.82e-03	1261	149	14	EFO_0004338
Disease	cannabis dependence	SLC28A3 REV3L CADM2 NOL4L	4.96e-03	135	149	4	EFO_0007191
Disease	Eczema	IKZF2 IQGAP1 NFATC2 PLCL1 ARHGAP27 PRORP	5.02e-03	310	149	6	HP_0000964

Protein segments in the cluster

Peptide	Gene	Start	Entry
PQRIHQMAANHVSIT	AFF3	1151	P51826
PDFTETREKQQHMVQ	ERICH3	1501	Q5RHP9
MIQAHISVSTQPNEV	EPG5	1126	Q9HCE0
VPEHRMYENQSQVVL	BDP1	1636	A6H8Y1
HSQAPQSSMQEIRQV	ADCK1	126	Q86TW2
VEVNVLHSMNRVAHP	CLSTN3	796	Q9BQT9
AVDVHINMEQAPIQS	BAG6	146	P46379
AVTPEERHLSKMQQN	APP	741	P05067
IQNASHRVVMITGDN	ATP13A1	736	Q9HD20
SRHSPVQMNRNLSNE	FCHO2	391	Q0JRZ9
PEVSRETQRTPMNHQ	FBXO34	16	Q9NWN3
ETQRTPMNHQKAVND	FBXO34	21	Q9NWN3
VEQIHQQKMAREPAT	APOA5	41	Q6Q788
QQQQHAREMSEVTAE	CEP72	491	Q9P209
MESHRNANAEPAVQR	CD99	166	P14209
NQSLPQEIARHCMVQ	CDADC1	311	Q9BWV3
MDPTQDQRSTEHQLV	DNHD1	961	Q96M86
VQAMDCETHSPQVRQ	DYRK1A	546	Q13627
QHQAMERDSTGIVTP	ANKRD17	2496	O75179
NVTDHMERQVQSNDI	CCDC157	576	Q569K6
HMIHEEQSAQPNASQ	EFCAB12	141	Q6NXP0
NERMAHQQRKSPSVS	ASXL3	761	Q9C0F0
QTMQERVHPEVQRHL	ARHGEF12	466	Q9NZN5
PATSEQEAEHQRAMQ	IQGAP1	1411	P46940
PMDAAQRSQHIQACI	MKRN4P	281	Q13434
ERQPRSTAQVHLDSM	NR2E3	121	Q9Y5X4
AENSQQLPCMRNTHV	RFX4	566	Q33E94
LQNMEVPAVSRQHAT	RIC1	946	Q4ADV7
DNMTNEMEQRVEPHN	INTS7	871	Q9NVH2
DPKVQELQASMAQHR	PHLDB3	261	Q6NSJ2
RLPNHDTNVVIQQAM	CREB5	121	Q02930
HQHTLTVMVRDQDVP	FAT1	1526	Q14517
QRSAHELPMVERQDT	NFATC2	571	Q13469
HVRDANDNQPSMTVI	DCHS1	351	Q96JQ0
FLSPAETHQRMAAEN	OR8G5	26	Q8NG78
MNVGVAHSEVNPNTR	ORMDL2	1	Q53FV1
AHSEVNPNTRVMNSR	ORMDL2	6	Q53FV1
LTSRHQEAEMAQNAV	CTNNB1	471	P35222
MEHELSISEQQQPVQ	LRRC37A3	351	O60309
PESIVIMHASNNDVQ	JHY	411	Q6NUN7
MEHELSISEQQQPVQ	LRRC37A2	351	A6NM11
MEHELSISEQQQPVQ	LRRC37A	351	A6NMS7
DSQVAEENRFHPSML	RNGTT	36	O60942
QQAIHMETDPQTISA	INTS1	1051	Q8N201
RTMEQFTIHLTVNPQ	ITIH1	141	P19827
QQHAGETDPVTTMRA	HAGH	281	Q16775
EQIRRMNENSHVQVP	CSN1S1	121	P47710
QNPDSLHRESMRNAV	DCUN1D2	46	Q6PH85
EMARVLTDSNHVPLQ	FBXO33	321	Q7Z6M2
SDFINRMHNQIPQVT	DDX1	381	Q92499
TNQAAPSAVSIMHQV	EPHB2	431	P29323
VVVSNCMEDPQRHTN	HSP90AA5P	271	Q58FG0
TVMVNITDVNEHRPQ	FAT2	3306	Q9NYQ8
QEVARREMPSDNHQE	LRRC36	236	Q1X8D7
SPVDNHMRNLTSQDL	NFE2L3	366	Q9Y4A8
VCREAGPQAHMQQVT	FGFBP2	116	Q9BYJ0
VEAVVQTRDQMVGSH	KANK1	516	Q14678
LQVSAQLHGDRMQET	KRT78	311	Q8N1N4
PHMAEQTFEQAIQAA	CDC25B	121	P30305
LSSQPSIDEVRQQMH	KIAA1549L	1541	Q6ZVL6
QDHLTHVVNSVMQPQ	LRGUK	386	Q96M69
HVVNSVMQPQRIFDS	LRGUK	391	Q96M69
QDERMRSPQNLHSQE	NOL4L	21	Q96MY1
QVVRHVINSAAAQME	MROH1	371	Q8NDA8
MNVGVAHSEVNPNTR	ORMDL1	1	Q9P0S3
AHSEVNPNTRVMNSR	ORMDL1	6	Q9P0S3
RPISRETADSHENNM	IKZF2	366	Q9UKS7
EPVRADSPVHMEQQS	MED26	441	O95402
DSPVHMEQQSRTELD	MED26	446	O95402
STVRIQVMDVNDNAP	PCDHB12	331	Q9Y5F1
HATFPDQEVRRMAVQ	PIK3C2B	891	O00750
NITVMDVNDNHPAFL	DCHS2	966	Q6V1P9
SPMLQAQEQCHREQL	OBSCN	6201	Q5VST9
DAAVMNQEPAGHRTV	KIR2DL4	271	Q99706
LLRQNMQHEPAFDSS	ITPRIPL1	126	Q6GPH6
MAPTIQTQAQREDGH	PAF1	1	Q8N7H5
TVVMHRTEPTAQQNL	EIF3C	841	Q99613
QTVVMHRTEPTAQQN	EIF3CL	841	B5ME19
RKQVDSEHMHQNVPT	ATRX	466	P46100
SEHMHQNVPTEEQRT	ATRX	471	P46100
HPQREMLTAQNRFEV	FAM126A	166	Q9BYI3
SMATQNLPEQHVSER	E2F5	266	Q15329
AMQHANQPDETIFQA	DOCK4	1361	Q8N1I0
NNPESQSMHLETRLV	EIF3A	221	Q14152
QASIDRLPDHSMVQI	FBXL7	111	Q9UJT9
PTMARQVRTHQETLN	C3orf20	121	Q8ND61
SHDSRSMALPQEQSQ	PYHIN1	406	Q6K0P9
VTSNPEDHERILMQV	C2orf74	61	A8MZ97
DHESLNATPQVAMQV	CADM2	206	Q8N3J6
TPEQLHSMRQAELAQ	COA3	31	Q9Y2R0
VRQMHQNAPRSQIAT	BRWD1	716	Q9NSI6
DREPNTKVRTCMHNQ	BRWD1	2196	Q9NSI6
SMDSQQTDFRAHNVP	FMNL2	6	Q96PY5
QVVENMTRAHFPLDV	GAA	386	P10253
AQVFMNPSHIQLEDQ	KIAA1210	691	Q9ULL0
AIHNITVLAMESQNP	CDH7	446	Q9ULB5
RNQMTPDFSRQSHDK	FBXO16	251	Q8IX29
IQETMQATIHVPAQH	HMBS	291	P08397
PVISDEDSHRQMIRN	CEP295	566	Q9C0D2
AAVNSMPVDNRNHNE	CHGB	16	P05060
SNVDTSVIPFQNDMH	PMS1	381	P54277
VHAMPVVDSGNRQED	C4orf19	261	Q8IY42
QDPTKVEAHVRAQMA	PRPF3	491	O43395
AVSKAPSMDAQQERH	POM121L1P	276	Q3SYA9
AHSEVNPNTRVMNSR	ORMDL3	6	Q8N138
QSGRHSVSVEVQMQR	PARD3	1191	Q8TEW0
PMQSILNSLEQQHEE	KIF13B	606	Q9NQT8
PHVFQRMEAENLASV	UTP25	576	Q68CQ4
IQPSTQDREHSGMNV	RBM6	296	P78332
KNMIIDPNDNRHSSE	SPHKAP	686	Q2M3C7
DVAHLVQPSQADARM	TRMT1	201	Q9NXH9
TPMAQAEAQAHLQSS	SPATA31C2	346	B4DYI2
VINRNMVEPSQHIFD	RGS20	336	O76081
IHSPMNDQQISQESR	RESF1	866	Q9HCM1
LRPVQVMQNANHVTS	POGZ	126	Q7Z3K3
RVIEHGEQNRMSVQS	ARHGAP27	831	Q6ZUM4
TPLHNAVQMSREDIV	RNASEL	61	Q05823
ETPTEANHVQRLRQM	SLC9B2	61	Q86UD5
SVLQSDIGQDMRVHN	SETX	391	Q7Z333
EMPHIEAQQRAVAIN	POLR3F	41	Q9H1D9
SVTEVRVAENNQPMN	SI	886	P14410
NEEPSRGQMTQTHRS	RNF169	251	Q8NCN4
QVTVEQDSPRNREHM	SLC28A3	56	Q9HAS3
SEAEQTERNIHPTAM	HERC2P3	676	Q9BVR0
NPTMDAQAQDRCHRI	SRCAP	2141	Q6ZRS2
HPVMSVLNLSRSEEN	STXBP4	526	Q6ZWJ1
MNSQTEDHALAPVRN	PRORP	96	O15091
QRVAQSPHTKMDVAN	RACGAP1	481	Q9H0H5
NDHNRRIQVEHPQMT	SSX1	86	Q16384
VIQHRFESLEPEMNN	SPTBN1	886	Q01082
LRHMAQTANQDPASI	CLCN3	801	P51790
MESLQTPQHRENQDK	RPP38-DT	1	Q8N326
TMQVDEHARPQTTLE	ACAA2	216	P42765
NVIANHPQMSALITD	TSPY10	161	P0CW01
DAMRPQQLHATEITS	VWA1	211	Q6PCB0
DNEPILCNRNNMTTH	PLCL1	451	Q15111
NVIANHPQMSALITD	TSPY2	161	A6NKD2
LNVTSHRVEMPRQNS	TNIK	626	Q9UKE5
PDMQHRSSVQTQGEV	ZFAT	616	Q9P243
SVDHREVQVLSQSMP	ZNF250	171	P15622
PSMVNNEQRQHAEHI	XPO4	26	Q9C0E2
NVIANHPQMSALITD	TSPY1	161	Q01534
SSPHFQAEQRVMSRV	SUN2	266	Q9UH99
NETSQMSQPESQDHR	REV3L	276	O60673
VTQNVHEERMENNQP	SAGE1	531	Q9NXZ1
ATQQSPFMVDLHEQV	RNF44	86	Q7L0R7
SPRVEAQNEMGQHIH	TP53INP1	156	Q96A56
DQSEAPVRQNHEEIM	TRAF6	436	Q9Y4K3
SRQTNRHLVDETMDP	NUP188	246	Q5SRE5
EDHMSFINNPNLTVR	SCN8A	1081	Q9UQD0
QQQDISVMTIPEHSD	RFX7	701	Q2KHR2
RESQQLMDSHPEQKE	SPTB	1016	P11277
VLMDENQTSRPVAVH	TFDP3	16	Q5H9I0
NVIANHPQMSALITD	TSPY3	161	P0CV98
NVIANHPQMSALITD	TSPY8	161	P0CW00
TVQPQRMHNRETHVN	ZNF582	466	Q96NG8
EHTLERNPMNVRNAE	ZNF844	606	Q08AG5
EALAQHMNISTVERP	ZNF140	146	P52738
METNPAFVQTVLHNT	ZZEF1	411	O43149
SEVHMRDPNNQLHVI	TRAPPC8	51	Q9Y2L5
HVTPEIMNQEERESS	ZNF131	566	P52739
ELQDSVLQDRSMPHQ	ZNF148	41	Q9UQR1
SKNIIMPEEEHQQNS	ZNF407	1091	Q9C0G0
LTQVVHPSAAMASQE	ZNF407	2056	Q9C0G0
HPSAAMASQERAQVA	ZNF407	2061	Q9C0G0
PNLQRMSQACHEVDD	TTC39C	466	Q8N584
TFENVRMPSHQGAEQ	SEC31A	406	O94979
APVATNHQSREVEMS	SIGLEC10	71	Q96LC7
MEQDRTNHVEGNRLS	TET2	1	Q6N021
MNTPRAHTVEEVNTD	TIPIN	231	Q9BVW5
SEQAEMRAVTPENHE	N4BP2	1201	Q86UW6
NDEHVNKMNSDRVPD	NMD3	386	Q96D46
PDAMSLEHTRNVNQI	NEB	1416	P20929
TPEMERVKHNQENIS	NEB	6291	P20929