Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctiondeaminase activity

APOBEC3G ADAT1 APOBEC3A

4.60e-0534413GO:0019239
GeneOntologyMolecularFunctionhydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines

APOBEC3G ADAT1 APOBEC3A

5.47e-0536413GO:0016814
GeneOntologyMolecularFunctionUDP-xylosyltransferase activity

XYLT1 GXYLT1

2.24e-0411412GO:0035252
GeneOntologyMolecularFunctionxylosyltransferase activity

XYLT1 GXYLT1

2.24e-0411412GO:0042285
GeneOntologyMolecularFunctioncytidine deaminase activity

APOBEC3G APOBEC3A

3.16e-0413412GO:0004126
GeneOntologyMolecularFunctionubiquitin binding

USPL1 NBR1 TAB3

1.38e-03107413GO:0043130
GeneOntologyMolecularFunctionzinc ion binding

APOBEC3G ZDHHC15 ARIH1 NBR1 TAB3 APOBEC3A RECQL4

2.05e-03891417GO:0008270
GeneOntologyMolecularFunctionubiquitin-like protein binding

USPL1 NBR1 TAB3

2.30e-03128413GO:0032182
GeneOntologyMolecularFunctionhydrolase activity, acting on carbon-nitrogen (but not peptide) bonds

APOBEC3G ADAT1 APOBEC3A

3.33e-03146413GO:0016810
GeneOntologyMolecularFunctionubiquitin-like protein transferase activity

RNF214 RNF183 ARIH1 NSMCE1 RNF212

3.80e-03512415GO:0019787
GeneOntologyMolecularFunctionaminoacyltransferase activity

RNF214 RNF183 ARIH1 NSMCE1 RNF212

4.47e-03532415GO:0016755
GeneOntologyMolecularFunctionacyltransferase activity

RNF214 ZDHHC15 RNF183 ARIH1 NSMCE1 RNF212

4.73e-03775416GO:0016746
GeneOntologyBiologicalProcessDNA cytosine deamination

APOBEC3G APOBEC3A

1.63e-0410402GO:0070383
GeneOntologyBiologicalProcesscytidine to uridine editing

APOBEC3G APOBEC3A

2.39e-0412402GO:0016554
GeneOntologyBiologicalProcesscytidine metabolic process

APOBEC3G APOBEC3A

3.29e-0414402GO:0046087
GeneOntologyBiologicalProcesscytidine catabolic process

APOBEC3G APOBEC3A

3.29e-0414402GO:0006216
GeneOntologyBiologicalProcesscytidine deamination

APOBEC3G APOBEC3A

3.29e-0414402GO:0009972
GeneOntologyBiologicalProcessDNA deamination

APOBEC3G APOBEC3A

3.29e-0414402GO:0045006
GeneOntologyBiologicalProcessnegative regulation of single stranded viral RNA replication via double stranded DNA intermediate

APOBEC3G APOBEC3A

4.33e-0416402GO:0045869
GeneOntologyBiologicalProcesspyrimidine ribonucleoside metabolic process

APOBEC3G APOBEC3A

4.33e-0416402GO:0046131
GeneOntologyBiologicalProcesspyrimidine ribonucleoside catabolic process

APOBEC3G APOBEC3A

4.33e-0416402GO:0046133
GeneOntologyBiologicalProcesspyrimidine nucleoside catabolic process

APOBEC3G APOBEC3A

5.50e-0418402GO:0046135
GeneOntologyBiologicalProcessregulation of single stranded viral RNA replication via double stranded DNA intermediate

APOBEC3G APOBEC3A

6.14e-0419402GO:0045091
GeneOntologyBiologicalProcessbase conversion or substitution editing

APOBEC3G APOBEC3A

6.14e-0419402GO:0016553
GeneOntologyBiologicalProcesssingle stranded viral RNA replication via double stranded DNA intermediate

APOBEC3G APOBEC3A

6.82e-0420402GO:0039692
DomainPLAC

PCSK5 ADAMTS18 ADAMTSL3

3.26e-0614403PF08686
DomainPLAC

PCSK5 ADAMTS18 ADAMTSL3

8.61e-0619403PS50900
DomainPLAC

PCSK5 ADAMTS18 ADAMTSL3

8.61e-0619403IPR010909
DomainTSP_1

ADAMTS18 HMCN1 ADAMTSL3 SSPOP

9.81e-0663404PF00090
DomainTSP1

ADAMTS18 HMCN1 ADAMTSL3 SSPOP

1.11e-0565404SM00209
DomainTSP1_rpt

ADAMTS18 HMCN1 ADAMTSL3 SSPOP

1.11e-0565404IPR000884
DomainTSP1

ADAMTS18 HMCN1 ADAMTSL3 SSPOP

1.11e-0565404PS50092
DomainAPOBEC_N

APOBEC3G APOBEC3A

2.91e-0412402PF08210
DomainTIL

SSPOP MUC6

2.91e-0412402PF01826
DomainAPOBEC_N

APOBEC3G APOBEC3A

2.91e-0412402IPR013158
DomainC8

SSPOP MUC6

2.91e-0412402PF08742
DomainUnchr_dom_Cys-rich

SSPOP MUC6

3.44e-0413402IPR014853
DomainC8

SSPOP MUC6

3.44e-0413402SM00832
DomainTIL_dom

SSPOP MUC6

4.00e-0414402IPR002919
DomainAPOBEC/CMP_deaminase_Zn-bd

APOBEC3G APOBEC3A

4.00e-0414402IPR016192
DomainVWD

SSPOP MUC6

5.27e-0416402SM00216
DomainVWF_type-D

SSPOP MUC6

5.27e-0416402IPR001846
DomainVWFD

SSPOP MUC6

5.27e-0416402PS51233
DomainVWD

SSPOP MUC6

5.27e-0416402PF00094
DomainCytidine_deaminase-like

APOBEC3G APOBEC3A

5.96e-0417402IPR016193
DomainCYT_DCMP_DEAMINASES_1

APOBEC3G APOBEC3A

5.96e-0417402PS00903
DomainCMP_dCMP_Zn-bd

APOBEC3G APOBEC3A

5.96e-0417402IPR002125
DomainZnf_RING

RNF214 RNF183 ARIH1 NSMCE1 RNF212

6.26e-04326405IPR001841
DomainVWC_out

SSPOP MUC6

7.47e-0419402SM00215
DomainPeptidase_M12B_ADAM-TS

ADAMTS18 ADAMTSL3

1.20e-0324402IPR013273
DomainCys_knot_C

SSPOP MUC6

1.30e-0325402IPR006207
DomainCTCK_2

SSPOP MUC6

1.30e-0325402PS01225
DomainPID

APBB3 APBB2

1.63e-0328402PF00640
DomainEGF_1

HMCN1 SSPOP ITGB6 CRB2

2.11e-03255404PS00022
DomainPID

APBB3 APBB2

2.13e-0332402PS01179
DomainEGF_2

HMCN1 SSPOP ITGB6 CRB2

2.42e-03265404PS01186
DomainPTB

APBB3 APBB2

3.31e-0340402SM00462
DomainZF_RING_1

RNF214 RNF183 ARIH1 RNF212

3.39e-03291404PS00518
DomainPTB/PI_dom

APBB3 APBB2

3.48e-0341402IPR006020
DomainVWF_dom

SSPOP MUC6

3.65e-0342402IPR001007
DomainZF_RING_2

RNF214 RNF183 ARIH1 RNF212

3.69e-03298404PS50089
DomainRING

RNF214 RNF183 ARIH1 RNF212

4.01e-03305404SM00184
DomainWW

APBB3 APBB2

4.55e-0347402PF00397
DomainWW

APBB3 APBB2

4.74e-0348402SM00456
DomainWW_DOMAIN_2

APBB3 APBB2

5.34e-0351402PS50020
DomainWW_DOMAIN_1

APBB3 APBB2

5.34e-0351402PS01159
DomainWW_dom

APBB3 APBB2

5.54e-0352402IPR001202
DomainIg_I-set

HMCN1 ADAMTSL3 CDON

7.77e-03190403IPR013098
Domainig

HMCN1 ADAMTSL3 CDON

7.77e-03190403PF00047
DomainImmunoglobulin

HMCN1 ADAMTSL3 CDON

7.77e-03190403IPR013151
DomainI-set

HMCN1 ADAMTSL3 CDON

7.77e-03190403PF07679
DomainUBA-like

NBR1 TAB3

8.29e-0364402IPR009060
PathwayREACTOME_DISEASES_ASSOCIATED_WITH_O_GLYCOSYLATION_OF_PROTEINS

ADAMTS18 ADAMTSL3 SSPOP MUC6

4.89e-0668244M27303
PathwayREACTOME_O_LINKED_GLYCOSYLATION

ADAMTS18 ADAMTSL3 SSPOP MUC6

3.19e-05109244MM15164
PathwayREACTOME_O_LINKED_GLYCOSYLATION

ADAMTS18 ADAMTSL3 SSPOP MUC6

3.43e-05111244M27416
PathwayREACTOME_O_GLYCOSYLATION_OF_TSR_DOMAIN_CONTAINING_PROTEINS

ADAMTS18 ADAMTSL3 SSPOP

3.81e-0539243M27417
PathwayREACTOME_O_GLYCOSYLATION_OF_TSR_DOMAIN_CONTAINING_PROTEINS

ADAMTS18 ADAMTSL3 SSPOP

3.81e-0539243MM15165
PathwayREACTOME_DISEASES_OF_GLYCOSYLATION

ADAMTS18 ADAMTSL3 SSPOP MUC6

9.21e-05143244M27275
PathwayREACTOME_DISEASES_OF_METABOLISM

ADAMTS18 ADAMTSL3 SSPOP MUC6

7.76e-04250244M27554
Pubmed

O-fucosylation of thrombospondin type 1 repeats restricts epithelial to mesenchymal transition (EMT) and maintains epiblast pluripotency during mouse gastrulation.

ADAMTS18 HMCN1 ADAMTSL3 SSPOP

1.90e-067541420637190
Pubmed

Targeting APOBEC3A to the viral nucleoprotein complex confers antiviral activity.

APOBEC3G APOBEC3A

4.06e-06341217727729
Pubmed

Evolution of the primate APOBEC3A cytidine deaminase gene and identification of related coding regions.

APOBEC3G APOBEC3A

4.06e-06341222272271
Pubmed

Evidence of oxidative stress and in vivo neurotoxicity of beta-amyloid in a transgenic mouse model of Alzheimer's disease: a chronic oxidative paradigm for testing antioxidant therapies in vivo.

APBB3 APBB2

4.06e-0634129546346
Pubmed

[Human Papillomavirus Carcinogenesis Mediated by APOBEC Mutagenesis].

APOBEC3G APOBEC3A

4.06e-06341230606934
Pubmed

Regulatory variants of APOBEC3 genes potentially associate with COVID-19 severity in populations with African ancestry.

APOBEC3G APOBEC3A

4.06e-06341238105291
Pubmed

Generation of the beta-amyloid peptide and the amyloid precursor protein C-terminal fragment gamma are potentiated by FE65L1.

APBB3 APBB2

4.06e-06341214527950
Pubmed

The roles of APOBEC-mediated RNA editing in SARS-CoV-2 mutations, replication and fitness.

APOBEC3G APOBEC3A

4.06e-06341236100631
Pubmed

Regulation of tumor necrosis factor-and Fas-mediated apoptotic cell death by a novel cDNA TR2L.

APBB3 APBB2

8.12e-0644128858135
Pubmed

HIV-1 Vif interaction with APOBEC3 deaminases and its characterization by a new sensitive assay.

APOBEC3G APOBEC3A

8.12e-06441221279453
Pubmed

Host restriction of HIV-1 by APOBEC3 and viral evasion through Vif.

APOBEC3G APOBEC3A

1.35e-05541220012521
Pubmed

Different modes of retrovirus restriction by human APOBEC3A and APOBEC3G in vivo.

APOBEC3G APOBEC3A

1.35e-05541224851906
Pubmed

Structure-guided analysis of the human APOBEC3-HIV restrictome.

APOBEC3G APOBEC3A

2.03e-05641224657093
Pubmed

An anthropoid-specific locus of orphan C to U RNA-editing enzymes on chromosome 22.

APOBEC3G APOBEC3A

2.84e-05741211863358
Pubmed

APOBEC3A is a potent inhibitor of adeno-associated virus and retrotransposons.

APOBEC3G APOBEC3A

2.84e-05741216527742
Pubmed

Human and rhesus APOBEC3D, APOBEC3F, APOBEC3G, and APOBEC3H demonstrate a conserved capacity to restrict Vif-deficient HIV-1.

APOBEC3G APOBEC3A

2.84e-05741221835787
Pubmed

USP15 potentiates NF-κB activation by differentially stabilizing TAB2 and TAB3.

NBR1 TAB3

3.78e-05841231903660
Pubmed

APOBEC3G: an intracellular centurion.

APOBEC3G APOBEC3A

3.78e-05841219008196
Pubmed

APOBEC3 deaminases induce hypermutation in human papillomavirus 16 DNA upon beta interferon stimulation.

APOBEC3G APOBEC3A

3.78e-05841224227842
Pubmed

APOBEC proteins and intrinsic resistance to HIV-1 infection.

APOBEC3G APOBEC3A

3.78e-05841219038776
Pubmed

Proteomics analysis of cardiac extracellular matrix remodeling in a porcine model of ischemia/reperfusion injury.

HMCN1 SSPOP CDON

6.03e-056441322261194
Pubmed

Essential roles for the FE65 amyloid precursor protein-interacting proteins in brain development.

APBB3 APBB2

6.07e-051041216407979
Pubmed

Messenger RNA editing in mammals: new members of the APOBEC family seeking roles in the family business.

APOBEC3G APOBEC3A

7.41e-051141212683974
Pubmed

HIV-1 replication and APOBEC3 antiviral activity are not regulated by P bodies.

APOBEC3G APOBEC3A

7.41e-051141222915799
Pubmed

Local anesthetics impair the growth and self-renewal of glioblastoma stem cells by inhibiting ZDHHC15-mediated GP130 palmitoylation.

ZDHHC15 SSPOP MUC6

8.22e-057141333541421
Pubmed

A quantitative protein interaction network for the ErbB receptors using protein microarrays.

APBB3 APBB2 SUPT6H

1.66e-049041316273093
Pubmed

Multiple APOBEC3 restriction factors for HIV-1 and one Vif to rule them all.

APOBEC3G APOBEC3A

1.82e-041741224189052
Pubmed

Fine mapping and association studies of a high-density lipoprotein cholesterol linkage region on chromosome 16 in French-Canadian subjects.

ADAMTS18 ADAT1

7.87e-043541219844255
Pubmed

CBFβ stabilizes HIV Vif to counteract APOBEC3 at the expense of RUNX1 target gene expression.

XYLT1 APOBEC3G CALHM6

9.45e-0416341323333304
Pubmed

The von Hippel-Lindau Cullin-RING E3 ubiquitin ligase regulates APOBEC3 cytidine deaminases.

APOBEC3G APOBEC3A

1.03e-034041234004371
Cytoband22q13.1-q13.2

APOBEC3G APOBEC3A

4.66e-06441222q13.1-q13.2
Cytoband2p11.2

TMEM150A SMYD1

1.51e-03644122p11.2
CytobandEnsembl 112 genes in cytogenetic band chr16q23

ADAMTS18 ADAT1

4.87e-03116412chr16q23
GeneFamilyApolipoprotein B mRNA editing enzyme catalytic subunits

APOBEC3G APOBEC3A

1.30e-0412262406
GeneFamilyBlood group antigens|CD molecules|I-set domain containing|Immunoglobulin like domain containing

HMCN1 ADAMTSL3 CDON

1.55e-03161263593
GeneFamilyRing finger proteins

RNF214 RNF183 RNF212

6.99e-0327526358
GeneFamilyImmunoglobulin like domain containing

ADAMTSL3 CDON

3.11e-02193262594
CoexpressionGSE3691_IFN_PRODUCING_KILLER_DC_VS_CONVENTIONAL_DC_SPLEEN_DN

PCSK5 ADAMTS18 CALHM6 CFAP161 SSPOP

1.47e-05200415M6366
ToppCellTCGA-Colorectal-Solid_Tissue_Normal-Rectum_normal_tissue-Rectum_normal_tissue-9|TCGA-Colorectal / Sample_Type by Project: Shred V9

ADAMTSL3 SMYD1 CDON SORCS1

1.37e-05159414f376bf6cd0ed374211edac3c384f3a78f0caef2a
ToppCellE18.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2-AF2_prolif|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PCSK5 CEP152 ADAT1 SYNGR4

2.19e-05179414ce3ca7f3a5864e62307aa744a3173f350a90df28
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

APBB2 HMCN1 ITGB6 RGL3

2.59e-05187414f124d2c699b717b7c02a1a70493f515b83dc2f4c
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

APBB2 HMCN1 ITGB6 RGL3

2.71e-05189414e32172ad09e93f6ac6ea2b92145b2b73003f7970
ToppCelldistal-Hematologic-Nonclassical_Monocyte-1|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

XYLT1 CALHM6 KREMEN2 APOBEC3A

3.00e-05194414f1cabb198ab32deaf299899c5e8f42d861b8c574
ToppCelldistal-1-Hematologic-Nonclassical_Monocyte|1 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

XYLT1 CALHM6 KREMEN2 APOBEC3A

3.06e-05195414e1a8171d1af53c2bbda758170c5053d3a3bb6ddd
ToppCellproximal-Hematologic-Nonclassical_Monocyte-3|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

XYLT1 CALHM6 MUC6 APOBEC3A

3.12e-051964147e136975e5943d42d51d8cc91c912547ef79cf4d
ToppCellproximal-3-Hematologic-Nonclassical_Monocyte|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

XYLT1 CALHM6 MUC6 APOBEC3A

3.12e-05196414e426d02c6bcff2358a45e627cc86389070a4af25
ToppCellproximal-Hematologic-Nonclassical_Monocyte|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

XYLT1 CALHM6 MUC6 APOBEC3A

3.12e-05196414439d695526714772971fd1a4a92b8b6a84eee1a4
ToppCellControl_saline-Mesenchymal_myocytic-Myofibroblastic-MatrixFB_->_Myofibroblast|Control_saline / Treatment groups by lineage, cell group, cell type

PCSK5 ADAMTSL3 RNF212 SORCS1

3.37e-05200414a799fc7bb83ad0524362cb5010df949741fb7bf3
ToppCellSubstantia_nigra-Macroglia-ASTROCYTE-Gja1-Astrocyte.Gja1.Igfbp2_(Igfbp2)|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

FAM181A NWD1 SMYD1

5.92e-058241389aff8676f98e062d0e69b38c7184e51aa1a915e
ToppCellSubstantia_nigra-Macroglia-ASTROCYTE-Gja1-Astrocyte.Gja1.Igfbp2_(Igfbp2)--|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

FAM181A NWD1 SMYD1

5.92e-05824136875a10abf1221b3dfd954c319b5e8e12fac1ff2
ToppCellSubstantia_nigra-Macroglia-ASTROCYTE-Gja1-Astrocyte.Gja1.Igfbp2_(Igfbp2)-|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

FAM181A NWD1 SMYD1

5.92e-0582413259bb4ae0373d8352cb1c3bff08f66b89a298440

Protein segments in the cluster

PeptideGeneStartEntry
FSDPQWNHFQGPSCQ

CEP152

171

O94986
GNQRFECHVFWCEPN

APBB2

676

Q92870
ECHVFWCEPNAGNVS

APBB2

681

Q92870
CWDTFVDHQGCPFQP

APOBEC3A

161

P31941
CWDTFVDHQGCPFQP

APOBEC3G

346

Q9HC16
EVSHVNCWQAAFPDP

CFAP161

186

Q6P656
TQVQACNSHACPPQW

ADAMTS18

981

Q8TE60
PSCVDFFNWCHLVPQ

ADAMTS18

1186

Q8TE60
FFNWCHLVPQHGVCN

ADAMTS18

1191

Q8TE60
QPCCPVFRNWAHNSS

ADAT1

156

Q9BUB4
CQQAQSWFQLCAHPV

NWD1

831

Q149M9
RQFCFNCGENWHDPV

ARIH1

301

Q9Y4X5
ANCTWHYQPCLCPSQ

MUC6

1151

Q6W4X9
SHCPDCGQQWFPSLE

TOR1AIP2

6

Q9H496
WPFCGNNIINHFLCE

OR13C4

166

Q8NGS5
WNDFHCTCPANFTGP

CRB2

826

Q5IJ48
CPSWKFEFENQCHPC

PCSK5

921

Q92824
CAWCAQENFTHPSGV

ITGB6

41

P18564
FHNPESLFVFPCQWN

GXYLT1

326

Q4G148
HNFCRNPDGDVQPWC

KREMEN2

86

Q8NCW0
HNVPQPWACDYQLFQ

RGL3

651

Q3MIN7
SDFCNSDPCPTHGNW

HMCN1

4746

Q96RW7
GRQSFQCAAFWCQPH

APBB3

381

O95704
AVAFQCPCSAAWNLP

CALHM6

36

Q5R3K3
FTCDVHGNPAPNCTW

CDON

331

Q4KMG0
QSNAEPRCPHCNDYW

NSMCE1

221

Q8WV22
NAWSCCPFQYHGQPI

FAM181A

271

Q8N9Y4
AECPVCWNPFNNTFH

RNF183

11

Q96D59
WNCTARHCPSQAFCP

SSPOP

911

A2VEC9
HVCPVENWSYNESCP

TMEM150A

31

Q86TG1
PWNCDSCTFLNHPAL

TAB3

686

Q8N5C8
LPENQFSWHIACNNC

NBR1

206

Q14596
NEQFDHWAAQCPRPA

RECQL4

406

O94761
HDCWPNCTVIFNNGN

SMYD1

206

Q8NB12
WQCPFCQQDNFPELS

SUPT6H

1196

Q7KZ85
MANWVFCNRCFQPPH

RNF212

1

Q495C1
FWAQTNTNDTCPFCP

RNF214

686

Q8ND24
WHPLNAAHFGPCNNC

USPL1

386

Q5W0Q7
WCGCSPNDFKPQDFH

XYLT1

571

Q86Y38
FCFLANQWQHSPPKE

SYNGR4

121

O95473
RHSNGQCLPAFWFNP

SORCS1

736

Q8WY21
DHHCPWVNNCIGFSN

ZDHHC15

156

Q96MV8
LQACNQFDCPPGWHI

ADAMTSL3

751

P82987
SHQLQCWLQAQPCPS

EXD3

81

Q8N9H8