Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	inward rectifier potassium channel activity	KCNJ4 KCNJ5 KCNJ9 KCNJ12 KCNJ18	2.88e-06	28	163	5	GO:0005242
GeneOntologyMolecularFunction	ligand-gated monoatomic cation channel activity	GRIN2C GRIN2D ITPR1 KCNJ4 KCNJ5 KCNJ9 KCNJ12 KCNJ18	1.99e-05	140	163	8	GO:0099094
GeneOntologyMolecularFunction	ligand-gated monoatomic ion channel activity	GABRB3 GRIN2C GRIN2D ITPR1 KCNJ4 KCNJ5 KCNJ9 KCNJ12 KCNJ18	3.04e-05	193	163	9	GO:0015276
GeneOntologyMolecularFunction	ligand-gated channel activity	GABRB3 GRIN2C GRIN2D ITPR1 KCNJ4 KCNJ5 KCNJ9 KCNJ12 KCNJ18	3.57e-05	197	163	9	GO:0022834
GeneOntologyMolecularFunction	cytidylate cyclase activity	GUCY1A1 GUCY1B1	6.62e-05	2	163	2	GO:0047805
GeneOntologyMolecularFunction	G-protein activated inward rectifier potassium channel activity	KCNJ5 KCNJ9	3.93e-04	4	163	2	GO:0015467
GeneOntologyMolecularFunction	minus-end-directed microtubule motor activity	DNAH1 DNAH9 DNAH11	3.98e-04	18	163	3	GO:0008569
GeneOntologyMolecularFunction	PDZ domain binding	GRIN2C KCNJ4 KCNJ9 KCNJ12 KCNJ18 EXOC4	5.22e-04	123	163	6	GO:0030165
GeneOntologyMolecularFunction	voltage-gated monoatomic ion channel activity	GRIN2C GRIN2D KCNJ4 KCNJ5 KCNJ9 KCNJ12 KCNJ18	7.52e-04	182	163	7	GO:0005244
GeneOntologyMolecularFunction	voltage-gated channel activity	GRIN2C GRIN2D KCNJ4 KCNJ5 KCNJ9 KCNJ12 KCNJ18	8.01e-04	184	163	7	GO:0022832
GeneOntologyMolecularFunction	succinate transmembrane transporter activity	SLC13A3 SLC25A10	9.72e-04	6	163	2	GO:0015141
GeneOntologyMolecularFunction	MAP kinase kinase kinase activity	LRRK2 MAP3K15 MAP3K21	1.35e-03	27	163	3	GO:0004709
GeneOntologyMolecularFunction	inorganic molecular entity transmembrane transporter activity	GABRB3 CNNM2 SLC13A3 GRIN2C GRIN2D PKD1L3 ITPR1 SLC18A3 KCNJ4 KCNJ5 KCNJ9 KCNJ12 SLC25A10 KCNJ18 MFSD5	1.40e-03	758	163	15	GO:0015318
GeneOntologyMolecularFunction	voltage-gated potassium channel activity	KCNJ4 KCNJ5 KCNJ9 KCNJ12 KCNJ18	1.50e-03	102	163	5	GO:0005249
GeneOntologyMolecularFunction	dynein light intermediate chain binding	DNAH1 DNAH9 DNAH11	1.51e-03	28	163	3	GO:0051959
GeneOntologyMolecularFunction	metal ion transmembrane transporter activity	CNNM2 SLC13A3 GRIN2C GRIN2D PKD1L3 ITPR1 KCNJ4 KCNJ5 KCNJ9 KCNJ12 KCNJ18	1.56e-03	465	163	11	GO:0046873
GeneOntologyMolecularFunction	voltage-gated monoatomic cation channel activity	GRIN2D KCNJ4 KCNJ5 KCNJ9 KCNJ12 KCNJ18	1.57e-03	152	163	6	GO:0022843
GeneOntologyMolecularFunction	DNA helicase activity	RECQL FBH1 SUPV3L1 DSCC1	1.65e-03	62	163	4	GO:0003678
GeneOntologyMolecularFunction	gated channel activity	GABRB3 GRIN2C GRIN2D ITPR1 KCNJ4 KCNJ5 KCNJ9 KCNJ12 KCNJ18	1.73e-03	334	163	9	GO:0022836
GeneOntologyMolecularFunction	glutamate-gated calcium ion channel activity	GRIN2C GRIN2D	1.80e-03	8	163	2	GO:0022849
GeneOntologyMolecularFunction	NMDA glutamate receptor activity	GRIN2C GRIN2D	1.80e-03	8	163	2	GO:0004972
GeneOntologyMolecularFunction	ligand-gated calcium channel activity	GRIN2C GRIN2D ITPR1	2.03e-03	31	163	3	GO:0099604
GeneOntologyMolecularFunction	monoatomic cation channel activity	GRIN2C GRIN2D PKD1L3 ITPR1 KCNJ4 KCNJ5 KCNJ9 KCNJ12 KCNJ18	2.08e-03	343	163	9	GO:0005261
Domain	ARM-type_fold	USP34 NCAPD3 DNAJC13 IPO8 DOCK11 MROH2A TTI2 SCYL3 LRRK2 TSC2 FRYL HUWE1 TRIP12 ITPR1 URB1 NCAPG MTOR ARID2 HEATR9 DIAPH1 MROH7 PDS5A PRKDC HECTD1 UNC79	2.76e-16	339	164	25	IPR016024
Domain	ARM-like	NCAPD3 DNAJC13 IPO8 MROH2A TTI2 SCYL3 LRRK2 TSC2 FRYL HUWE1 TRIP12 NCAPG MTOR ARID2 HEATR9 MROH7 PDS5A PRKDC HECTD1	3.01e-12	270	164	19	IPR011989
Domain	-	NCAPD3 DNAJC13 IPO8 SCYL3 LRRK2 TSC2 FRYL TRIP12 NCAPG MTOR HEATR9 MROH7 PDS5A PRKDC HECTD1	1.15e-09	222	164	15	1.25.10.10
Domain	HEAT_REPEAT	NCAPD3 MROH2A SCYL3 NCAPG MTOR MROH7 PDS5A PRKDC	1.77e-07	70	164	8	PS50077
Domain	IRK	KCNJ4 KCNJ5 KCNJ9 KCNJ12 KCNJ18	1.98e-07	16	164	5	PF01007
Domain	K_chnl_inward-rec_Kir_cyto	KCNJ4 KCNJ5 KCNJ9 KCNJ12 KCNJ18	1.98e-07	16	164	5	IPR013518
Domain	-	KCNJ4 KCNJ5 KCNJ9 KCNJ12 KCNJ18	1.98e-07	16	164	5	2.60.40.1400
Domain	K_chnl_inward-rec_Kir	KCNJ4 KCNJ5 KCNJ9 KCNJ12 KCNJ18	1.98e-07	16	164	5	IPR016449
Domain	Ig_E-set	ARRDC4 KCNJ4 KCNJ5 KCNJ9 KCNJ12 KCNJ18 PLXNB3	3.68e-05	104	164	7	IPR014756
Domain	DUF3657	FAM135B FAM135A	7.66e-05	2	164	2	IPR022122
Domain	DUF676	FAM135B FAM135A	7.66e-05	2	164	2	PF05057
Domain	DUF3657	FAM135B FAM135A	7.66e-05	2	164	2	PF12394
Domain	K_chnl_inward-rec_Kir2.2	KCNJ12 KCNJ18	7.66e-05	2	164	2	IPR003272
Domain	DUF676_lipase-like	FAM135B FAM135A	7.66e-05	2	164	2	IPR007751
Domain	Gamma_tubulin	TUBG2 TUBG1	7.66e-05	2	164	2	IPR002454
Domain	HEAT	NCAPD3 SCYL3 NCAPG MTOR PRKDC	1.55e-04	58	164	5	IPR000357
Domain	Dynein_heavy_chain_D4_dom	DNAH1 DNAH9 DNAH11	2.25e-04	14	164	3	IPR024317
Domain	Dynein_HC_stalk	DNAH1 DNAH9 DNAH11	2.25e-04	14	164	3	IPR024743
Domain	Dynein_heavy_dom-2	DNAH1 DNAH9 DNAH11	2.25e-04	14	164	3	IPR013602
Domain	DHC_N2	DNAH1 DNAH9 DNAH11	2.25e-04	14	164	3	PF08393
Domain	ATPase_dyneun-rel_AAA	DNAH1 DNAH9 DNAH11	2.25e-04	14	164	3	IPR011704
Domain	MT	DNAH1 DNAH9 DNAH11	2.25e-04	14	164	3	PF12777
Domain	AAA_8	DNAH1 DNAH9 DNAH11	2.25e-04	14	164	3	PF12780
Domain	AAA_5	DNAH1 DNAH9 DNAH11	2.25e-04	14	164	3	PF07728
Domain	K_chnl_inward-rec_Kir_N	KCNJ12 KCNJ18	2.29e-04	3	164	2	IPR013673
Domain	IRK_N	KCNJ12 KCNJ18	2.29e-04	3	164	2	PF08466
Domain	DHC_fam	DNAH1 DNAH9 DNAH11	2.80e-04	15	164	3	IPR026983
Domain	Dynein_heavy	DNAH1 DNAH9 DNAH11	2.80e-04	15	164	3	PF03028
Domain	Dynein_heavy_dom	DNAH1 DNAH9 DNAH11	2.80e-04	15	164	3	IPR004273
Domain	HNOB	GUCY1A1 GUCY1B1	4.55e-04	4	164	2	PF07700
Domain	FATC	MTOR PRKDC	7.53e-04	5	164	2	PF02260
Domain	HEAT	NCAPD3 SCYL3 NCAPG PRKDC	8.25e-04	48	164	4	PF02985
Domain	HNOB_dom_associated	GUCY1A1 GUCY1B1	1.12e-03	6	164	2	IPR011645
Domain	FAT	MTOR PRKDC	1.12e-03	6	164	2	PS51189
Domain	FATC	MTOR PRKDC	1.12e-03	6	164	2	PS51190
Domain	FAT	MTOR PRKDC	1.12e-03	6	164	2	PF02259
Domain	HNOBA	GUCY1A1 GUCY1B1	1.12e-03	6	164	2	PF07701
Domain	PIK-rel_kinase_FAT	MTOR PRKDC	1.12e-03	6	164	2	IPR003151
Domain	FATC_dom	MTOR PRKDC	1.12e-03	6	164	2	IPR003152
Domain	PIK_FAT	MTOR PRKDC	1.12e-03	6	164	2	IPR014009
Domain	FATC	MTOR PRKDC	1.12e-03	6	164	2	SM01343
Domain	HECT	HUWE1 TRIP12 HECTD1	1.67e-03	27	164	3	PF00632
Domain	HECTc	HUWE1 TRIP12 HECTD1	1.67e-03	27	164	3	SM00119
Domain	HECT_dom	HUWE1 TRIP12 HECTD1	1.67e-03	27	164	3	IPR000569
Domain	HECT	HUWE1 TRIP12 HECTD1	1.67e-03	27	164	3	PS50237
Domain	DHC_N1	DNAH9 DNAH11	2.07e-03	8	164	2	PF08385
Domain	NO_sig/Golgi_transp_ligand-bd	GUCY1A1 GUCY1B1	2.07e-03	8	164	2	IPR024096
Domain	Dynein_heavy_dom-1	DNAH9 DNAH11	2.07e-03	8	164	2	IPR013594
Pathway	REACTOME_ACTIVATION_OF_G_PROTEIN_GATED_POTASSIUM_CHANNELS	KCNJ4 KCNJ5 KCNJ9 KCNJ12 KCNJ18	3.37e-06	30	111	5	MM14542
Pathway	REACTOME_GABA_RECEPTOR_ACTIVATION	GABRB3 KCNJ4 KCNJ5 KCNJ9 KCNJ12 KCNJ18	7.37e-06	60	111	6	MM15708
Pathway	REACTOME_INWARDLY_RECTIFYING_K_CHANNELS	KCNJ4 KCNJ5 KCNJ9 KCNJ12 KCNJ18	8.58e-06	36	111	5	MM14544
Pathway	REACTOME_NEUROTRANSMITTER_RECEPTORS_AND_POSTSYNAPTIC_SIGNAL_TRANSMISSION	GABRB3 GRIN2C GRIN2D KCNJ4 KCNJ5 KCNJ9 KCNJ12 KCNJ18	1.78e-05	144	111	8	MM14501
Pathway	REACTOME_GABA_B_RECEPTOR_ACTIVATION	KCNJ4 KCNJ5 KCNJ9 KCNJ12 KCNJ18	2.35e-05	44	111	5	MM15709
Pathway	REACTOME_TRANSMISSION_ACROSS_CHEMICAL_SYNAPSES	GABRB3 GRIN2C GRIN2D SLC18A3 KCNJ4 KCNJ5 KCNJ9 KCNJ12 KCNJ18	4.29e-05	211	111	9	MM14502
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_SOD1_TO_RETROGRADE_AXONAL_TRANSPORT	ACTR10 DNAH1 DNAH9 DNAH11	5.56e-05	27	111	4	M47755
Pathway	REACTOME_GABA_RECEPTOR_ACTIVATION	GABRB3 KCNJ4 KCNJ5 KCNJ9 KCNJ12	1.07e-04	60	111	5	M976
Pathway	REACTOME_INWARDLY_RECTIFYING_K_CHANNELS	KCNJ4 KCNJ5 KCNJ9 KCNJ12	1.58e-04	35	111	4	M1075
Pathway	KEGG_MEDICUS_REFERENCE_FLT3LG_FLT3_RAS_PI3K_SIGNALING_PATHWAY	MTOR SOS1 SOS2	2.02e-04	15	111	3	M47475
Pathway	REACTOME_MUSCLE_CONTRACTION	MYL4 ITPR1 GUCY1A1 GUCY1B1 KCNJ4 KCNJ12 KCNJ18	3.25e-04	165	111	7	MM15026
Pathway	REACTOME_GABA_B_RECEPTOR_ACTIVATION	KCNJ4 KCNJ5 KCNJ9 KCNJ12	3.55e-04	43	111	4	M954
Pathway	KEGG_MEDICUS_REFERENCE_RETROGRADE_AXONAL_TRANSPORT	ACTR10 DNAH1 DNAH9 DNAH11	3.55e-04	43	111	4	M47669
Pathway	REACTOME_PHASE_4_RESTING_MEMBRANE_POTENTIAL	KCNJ4 KCNJ12 KCNJ18	4.20e-04	19	111	3	MM15194
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_HTT_TO_RETROGRADE_AXONAL_TRANSPORT	ACTR10 DNAH1 DNAH9 DNAH11	4.23e-04	45	111	4	M47670
Pathway	WP_NOCGMPPKG_MEDIATED_NEUROPROTECTION	GRIN2C GRIN2D GUCY1A1 GUCY1B1	5.00e-04	47	111	4	M39531
Pubmed	The inward rectifier potassium channel family.	KCNJ4 KCNJ5 KCNJ9 KCNJ12 KCNJ18	1.39e-11	6	166	5	7580148
Pubmed	A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.	USP34 NCAPD3 WDR36 IPO8 NOP56 ST7 TTI2 LARP1 RECQL TSC2 PSMD13 BCL3 HUWE1 COG3 TUBG1 ITPR1 NUP205 URB1 NCAPG POLR3B MTOR MRPS2 SCARB2 PDS5A PRKDC CNOT1 EXOC4	1.21e-09	1440	166	27	30833792
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	USP34 TUBG2 HECTD4 TSC2 HUWE1 TRIP12 DSCAML1 ME3 ODF2L POLR3B FBH1 GUCY1B1 SUPV3L1 PDE4DIP LRP1 NECAB3 TMEM131 METTL8 PRKDC HECTD1 PLXNB3 EXOC4 SOS1 SOS2	1.21e-08	1285	166	24	35914814
Pubmed	E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.	DOCK11 TTI2 LARP1 PIDD1 TSC2 BCL3 HUWE1 PARVG TRIP12 DSCAML1 NUP205 URB1 CCDC198 KCNJ9 PDS5A PRKDC CNOT1 PLXNB3	1.76e-08	736	166	18	29676528
Pubmed	LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.	NCAPD3 DNAJC13 LARP1 FRYL TRIP12 MTOR MROH7 PRKDC HECTD1 CNOT1	5.29e-08	202	166	10	33005030
Pubmed	Molecular cloning and functional expression of cDNA encoding a second class of inward rectifier potassium channels in the mouse brain.	KCNJ4 KCNJ12 KCNJ18	1.07e-07	3	166	3	8083233
Pubmed	The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.	NCAPD3 DNAJC13 WDR36 IPO8 NOP56 LARP1 ERI1 TRIP12 NUP205 URB1 POLR3B ARID2 PRKDC MED23 HECTD1 CNOT1 EXOC4	1.56e-07	759	166	17	35915203
Pubmed	Functional characterization of inward rectifier potassium ion channel in murine fetal ventricular cardiomyocytes.	KCNJ4 KCNJ12 KCNJ18	4.26e-07	4	166	3	20798526
Pubmed	The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation.	DNAJC13 IPO8 NOP56 PSMD13 HUWE1 TUBG1 NUP205 NCAPG MTOR DIAPH1 PDS5A PRKDC HECTD1 CNOT1 EXOC4	4.75e-07	638	166	15	33239621
Pubmed	International Union of Pharmacology. LIV. Nomenclature and molecular relationships of inwardly rectifying potassium channels.	KCNJ4 KCNJ5 KCNJ9 KCNJ12	6.56e-07	15	166	4	16382105
Pubmed	Dendritic excitability of mouse frontal cortex pyramidal neurons is shaped by the interaction among HCN, Kir2, and Kleak channels.	KCNJ4 KCNJ12 KCNJ18	1.06e-06	5	166	3	16177047
Pubmed	Monocilia in the embryonic mouse heart suggest a direct role for cilia in cardiac morphogenesis.	TUBG2 TUBG1 DNAH11	1.06e-06	5	166	3	18729223
Pubmed	Cloning provides evidence for a family of inward rectifier and G-protein coupled K+ channels in the brain.	KCNJ4 KCNJ5 KCNJ9	1.06e-06	5	166	3	7926018
Pubmed	PITX2 insufficiency leads to atrial electrical and structural remodeling linked to arrhythmogenesis.	COL3A1 KCNJ4 KCNJ12 KCNJ18	1.45e-06	18	166	4	21511879
Pubmed	CROCCP2 acts as a human-specific modifier of cilia dynamics and mTOR signaling to promote expansion of cortical progenitors.	TUBG2 TUBG1 MTOR	2.11e-06	6	166	3	36334595
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	USP34 WDR36 LARP1 RECQL FRYL HUWE1 TRIP12 NUP205 URB1 MTOR PDS5A PRKDC HECTD1 CNOT1	3.39e-06	653	166	14	22586326
Pubmed	Rare independent mutations in renal salt handling genes contribute to blood pressure variation.	KCNJ4 KCNJ5 KCNJ9 KCNJ12	3.42e-06	22	166	4	18391953
Pubmed	The variant Polycomb Repressor Complex 1 component PCGF1 interacts with a pluripotency sub-network that includes DPPA4, a regulator of embryogenesis.	USP34 NCAPD3 IPO8 TSC2 PSMD13 HUWE1 TUBG1 DNAAF2 CDAN1 FECH PRKDC	3.54e-06	396	166	11	26687479
Pubmed	Human immunodeficiency virus-1 protein Tat induces excitotoxic loss of presynaptic terminals in hippocampal cultures.	GRIN2C GRIN2D LRP1	3.69e-06	7	166	3	23267846
Pubmed	Human immunodeficiency virus protein Tat induces synapse loss via a reversible process that is distinct from cell death.	GRIN2C GRIN2D LRP1	3.69e-06	7	166	3	19036954
Pubmed	Evidence for association of GABA(B) receptors with Kir3 channels and regulators of G protein signalling (RGS4) proteins.	KCNJ4 KCNJ5 KCNJ9 KCNJ12	5.85e-06	25	166	4	17185339
Pubmed	HIV-tat induces formation of an LRP-PSD-95- NMDAR-nNOS complex that promotes apoptosis in neurons and astrocytes.	GRIN2C GRIN2D LRP1	5.88e-06	8	166	3	17360663
Pubmed	A genetic screen identifies the Triple T complex required for DNA damage signaling and ATM and ATR stability.	TTI2 MTOR PRKDC	5.88e-06	8	166	3	20810650
Pubmed	RSPO-LGR4 functions via IQGAP1 to potentiate Wnt signaling.	NCAPD3 DNAJC13 NUP205 URB1 DIAPH1 PRKDC CNOT1 CCDC157	6.20e-06	202	166	8	24639526
Pubmed	5-HT(6) receptor recruitment of mTOR as a mechanism for perturbed cognition in schizophrenia.	IPO8 COG3 NCAPG MTOR	8.06e-06	27	166	4	23027611
Pubmed	HIV-1 protein Tat produces biphasic changes in NMDA-evoked increases in intracellular Ca2+ concentration via activation of Src kinase and nitric oxide signaling pathways.	GUCY1A1 GUCY1B1 LRP1	8.78e-06	9	166	3	24666322
Pubmed	MITOPLD is a mitochondrial protein essential for nuage formation and piRNA biogenesis in the mouse germline.	TUBG2 TDRD1 TUBG1	8.78e-06	9	166	3	21397847
Pubmed	Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.	WDR36 DOCK11 HECTD4 LARP1 HUWE1 TRIP12 ITPR1 NUP205 ARID2 MED23 HECTD1	9.56e-06	440	166	11	34244565
Pubmed	Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.	KIAA0930 DOCK11 RALGAPB LARP1 TSC2 FRYL PARVG PRKDC MAP3K21 HECTD1 CNOT1	1.08e-05	446	166	11	24255178
Pubmed	A multiprotein trafficking complex composed of SAP97, CASK, Veli, and Mint1 is associated with inward rectifier Kir2 potassium channels.	KCNJ4 KCNJ12 KCNJ18	1.25e-05	10	166	3	14960569
Pubmed	Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes.	CMTR1 NOP56 RECQL HUWE1 TRIP12 CDAN1 ODF2L NCAPG DIAPH1 BRD1 MED23 CNOT1 EXOC4	1.47e-05	645	166	13	25281560
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	DNAJC13 NOP56 DOCK11 HECTD4 TSC2 GRIN2D HUWE1 SENP1 MTOR KCNJ4 PDE4DIP DIAPH1 LRP1 UNC79 CNOT1 CDH10	1.66e-05	963	166	16	28671696
Pubmed	Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells.	WDR36 NOP56 HUWE1 MORC4 TRIP12 NUP205 NCAPG INTS2 PDS5A UNC79 CNOT1	1.73e-05	469	166	11	27634302
Pubmed	LRRK2 Modulates the Exocyst Complex Assembly by Interacting with Sec8.	LRRK2 EXOC4	2.26e-05	2	166	2	33498474
Pubmed	Dual TORK/DNA-PK inhibition blocks critical signaling pathways in chronic lymphocytic leukemia.	MTOR PRKDC	2.26e-05	2	166	2	27235137
Pubmed	Structural insights into the mechanism of human soluble guanylate cyclase.	GUCY1A1 GUCY1B1	2.26e-05	2	166	2	31514202
Pubmed	Hypertension reduces soluble guanylyl cyclase expression in the mouse aorta via the Notch signaling pathway.	GUCY1A1 GUCY1B1	2.26e-05	2	166	2	28465505
Pubmed	Molecular cloning of the cDNAs coding for the two subunits of soluble guanylyl cyclase from human brain.	GUCY1A1 GUCY1B1	2.26e-05	2	166	2	1352257
Pubmed	Loss of TSC2 confers resistance to ceramide and nutrient deprivation.	TSC2 MTOR	2.26e-05	2	166	2	23604129
Pubmed	A homologue of the Drosophila Son of sevenless gene maps to mouse chromosome 17.	SOS1 SOS2	2.26e-05	2	166	2	8307589
Pubmed	Cellular signaling of amino acids towards mTORC1 activation in impaired human leucine catabolism.	MAP4K3 MTOR	2.26e-05	2	166	2	22898570
Pubmed	DNA-PK, Nuclear mTOR, and the Androgen Pathway in Prostate Cancer.	MTOR PRKDC	2.26e-05	2	166	2	32209447
Pubmed	Genomic organization of alpha1 and beta1 subunits of the mammalian soluble guanylyl cyclase genes.	GUCY1A1 GUCY1B1	2.26e-05	2	166	2	10984516
Pubmed	MTOC reorientation occurs during FcgammaR-mediated phagocytosis in macrophages.	TUBG2 TUBG1	2.26e-05	2	166	2	17442887
Pubmed	mTORC2 is required for proliferation and survival of TSC2-null cells.	TSC2 MTOR	2.26e-05	2	166	2	21482669
Pubmed	Overexpression of γ-tubulin in non-small cell lung cancer.	TUBG2 TUBG1	2.26e-05	2	166	2	22806905
Pubmed	Role of Kir2.2 in hypercapnic ventilatory response during postnatal development of mouse.	KCNJ12 KCNJ18	2.26e-05	2	166	2	15705530
Pubmed	mTOR Controls Mitochondrial Dynamics and Cell Survival via MTFP1.	MTFP1 MTOR	2.26e-05	2	166	2	28918902
Pubmed	Crystal structures of the catalytic domain of human soluble guanylate cyclase.	GUCY1A1 GUCY1B1	2.26e-05	2	166	2	23505436
Pubmed	Dysregulated mTORC1 renders cells critically dependent on desaturated lipids for survival under tumor-like stress.	TSC2 MTOR	2.26e-05	2	166	2	23699409
Pubmed	Rare loss of function mutations in N-methyl-D-aspartate glutamate receptors and their contributions to schizophrenia susceptibility.	GRIN2C GRIN2D	2.26e-05	2	166	2	29317596
Pubmed	PP2A T61 epsilon is an inhibitor of MAP4K3 in nutrient signaling to mTOR.	MAP4K3 MTOR	2.26e-05	2	166	2	20227368
Pubmed	LARP1 post-transcriptionally regulates mTOR and contributes to cancer progression.	LARP1 MTOR	2.26e-05	2	166	2	25531318
Pubmed	TSC2 regulates VEGF through mTOR-dependent and -independent pathways.	TSC2 MTOR	2.26e-05	2	166	2	12957289
Pubmed	Tsc2 is a molecular checkpoint controlling osteoblast development and glucose homeostasis.	TSC2 MTOR	2.26e-05	2	166	2	24591652
Pubmed	Ethanol opens G-protein-activated inwardly rectifying K+ channels.	KCNJ4 KCNJ5	2.26e-05	2	166	2	10570486
Pubmed	Inflammation in the Human Periodontium Induces Downregulation of the α1- and β1-Subunits of the sGC in Cementoclasts.	GUCY1A1 GUCY1B1	2.26e-05	2	166	2	33430449
Pubmed	NMDA GluN2C/2D receptors contribute to synaptic regulation and plasticity in the anterior cingulate cortex of adult mice.	GRIN2C GRIN2D	2.26e-05	2	166	2	33766086
Pubmed	Differential expression of alternative transcripts of soluble guanylyl cyclase, GYCY1a3 and GUCY1b3 genes, in the malignant and benign breast tumors.	GUCY1A1 GUCY1B1	2.26e-05	2	166	2	30597209
Pubmed	sGC(alpha)1(beta)1 attenuates cardiac dysfunction and mortality in murine inflammatory shock models.	GUCY1A1 GUCY1B1	2.26e-05	2	166	2	19502556
Pubmed	Critical Requirement of SOS1 for Development of BCR/ABL-Driven Chronic Myelogenous Leukemia.	SOS1 SOS2	2.26e-05	2	166	2	36010887
Pubmed	Allocation of gamma-tubulin between oocyte cortex and meiotic spindle influences asymmetric cytokinesis in the mouse oocyte.	TUBG2 TUBG1	2.26e-05	2	166	2	17287496
Pubmed	The downregulation of SASH1 expression promotes breast cancer occurrence and invasion accompanied by the activation of PI3K-Akt-mTOR signaling pathway.	SASH1 MTOR	2.26e-05	2	166	2	39300116
Pubmed	mTOR-related synaptic pathology causes autism spectrum disorder-associated functional hyperconnectivity.	TSC2 MTOR	2.26e-05	2	166	2	34667149
Pubmed	Synergistic mutations in soluble guanylyl cyclase (sGC) reveal a key role for interfacial regions in the sGC activation mechanism.	GUCY1A1 GUCY1B1	2.26e-05	2	166	2	31645439
Pubmed	Development of hypomelanotic macules is associated with constitutive activated mTORC1 in tuberous sclerosis complex.	TSC2 MTOR	2.26e-05	2	166	2	28336152
Pubmed	Non-collagen genes role in digenic Alport syndrome.	LAMA5 NPHS2	2.26e-05	2	166	2	30808327
Pubmed	Differential expression of human γ-tubulin isotypes during neuronal development and oxidative stress points to a γ-tubulin-2 prosurvival function.	TUBG2 TUBG1	2.26e-05	2	166	2	28119396
Pubmed	In the Telencephalon, GluN2C NMDA Receptor Subunit mRNA is Predominately Expressed in Glial Cells and GluN2D mRNA in Interneurons.	GRIN2C GRIN2D	2.26e-05	2	166	2	29651654
Pubmed	Decreased rates of cerebral protein synthesis measured in vivo in a mouse model of Tuberous Sclerosis Complex: unexpected consequences of reduced tuberin.	TSC2 MTOR	2.26e-05	2	166	2	29364507
Pubmed	Differential effect of NMDA receptor GluN2C and GluN2D subunit ablation on behavior and channel blocker-induced schizophrenia phenotypes.	GRIN2C GRIN2D	2.26e-05	2	166	2	31110197
Pubmed	Macrophage-induced tumor angiogenesis is regulated by the TSC2-mTOR pathway.	TSC2 MTOR	2.26e-05	2	166	2	22287548
Pubmed	Colocalization of the genes coding for the alpha 3 and beta 3 subunits of soluble guanylyl cyclase to human chromosome 4 at q31.3-q33.	GUCY1A1 GUCY1B1	2.26e-05	2	166	2	8097486
Pubmed	Tuberous Sclerosis Complex Protein 2-Independent Activation of mTORC1 by Human Cytomegalovirus pUL38.	TSC2 MTOR	2.26e-05	2	166	2	25972538
Pubmed	Enhanced function of NR2C/2D-containing NMDA receptor in the nucleus accumbens contributes to peripheral nerve injury-induced neuropathic pain and depression in mice.	GRIN2C GRIN2D	2.26e-05	2	166	2	35057644
Pubmed	mTOR-dependent synthesis of Bcl-3 controls the retraction of fibrin clots by activated human platelets.	BCL3 MTOR	2.26e-05	2	166	2	17110454
Pubmed	A role of the mammalian target of rapamycin (mTOR) in glutamate-induced down-regulation of tuberous sclerosis complex proteins 2 (TSC2).	TSC2 MTOR	2.26e-05	2	166	2	22492229
Pubmed	Absence of both Sos-1 and Sos-2 in peripheral CD4(+) T cells leads to PI3K pathway activation and defects in migration.	SOS1 SOS2	2.26e-05	2	166	2	25973715
Pubmed	Mutations in DNAH1, which encodes an inner arm heavy chain dynein, lead to male infertility from multiple morphological abnormalities of the sperm flagella.	DNAH1 DNAH11	2.26e-05	2	166	2	24360805
Pubmed	NMDA receptors containing GluN2C and GluN2D subunits have opposing roles in modulating neuronal oscillations; potential mechanism for bidirectional feedback.	GRIN2C GRIN2D	2.26e-05	2	166	2	31786200
Pubmed	Ablation of TSC2 enhances insulin secretion by increasing the number of mitochondria through activation of mTORC1.	TSC2 MTOR	2.26e-05	2	166	2	21886784
Pubmed	mTOR Hyperactivation by Ablation of Tuberous Sclerosis Complex 2 in the Mouse Heart Induces Cardiac Dysfunction with the Increased Number of Small Mitochondria Mediated through the Down-Regulation of Autophagy.	TSC2 MTOR	2.26e-05	2	166	2	27023784
Pubmed	LARP1 functions as a molecular switch for mTORC1-mediated translation of an essential class of mRNAs.	LARP1 MTOR	2.26e-05	2	166	2	28650797
Pubmed	Quaternary structure controls ligand dynamics in soluble guanylate cyclase.	GUCY1A1 GUCY1B1	2.26e-05	2	166	2	22223482
Pubmed	Revealing the clinical impact of MTOR and ARID2 gene mutations on MALT lymphoma of the alimentary canal using targeted sequencing.	MTOR ARID2	2.26e-05	2	166	2	39054516
Pubmed	Identification of murine homologues of the Drosophila son of sevenless gene: potential activators of ras.	SOS1 SOS2	2.26e-05	2	166	2	1631150
Pubmed	Identification of a soluble guanylate cyclase in RBCs: preserved activity in patients with coronary artery disease.	GUCY1A1 GUCY1B1	2.26e-05	2	166	2	29024896
Pubmed	SOS2 Comes to the Fore: Differential Functionalities in Physiology and Pathology.	SOS1 SOS2	2.26e-05	2	166	2	34205562
Pubmed	The Ras-specific exchange factors mouse Sos1 (mSos1) and mSos2 are regulated differently: mSos2 contains ubiquitination signals absent in mSos1.	SOS1 SOS2	2.26e-05	2	166	2	9372945
Pubmed	Nitric oxide mediates lymphatic vessel activation via soluble guanylate cyclase alpha1beta1-impact on inflammation.	GUCY1A1 GUCY1B1	2.26e-05	2	166	2	17855621
Pubmed	Gene knockout analysis of two gamma-tubulin isoforms in mice.	TUBG2 TUBG1	2.26e-05	2	166	2	15893303
Pubmed	Human soluble guanylate cyclase: functional expression and revised isoenzyme family.	GUCY1A1 GUCY1B1	2.26e-05	2	166	2	9742212
Pubmed	Chromosomal localization of two genes encoding human ras exchange factors: SOS1 maps to the 2p22-->p16 region and SOS2 to the 14q21-->q22 region of the human genome.	SOS1 SOS2	2.26e-05	2	166	2	8275713
Pubmed	Pancreatic β-cell failure mediated by mTORC1 hyperactivity and autophagic impairment.	TSC2 MTOR	2.26e-05	2	166	2	24740570
Pubmed	Gender-specific hypertension and responsiveness to nitric oxide in sGCalpha1 knockout mice.	GUCY1A1 GUCY1B1	2.26e-05	2	166	2	18339647
Pubmed	cGMP accumulation and gene expression of soluble guanylate cyclase in human vascular tissue.	GUCY1A1 GUCY1B1	2.26e-05	2	166	2	8613461
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	USP34 KIAA0930 HECTD4 LAMA5 TSC2 FRYL GRIN2D HUWE1 ITGA3 SH2B2 TUBG1 URB1 MTOR BTBD7 PRKDC HECTD1 MFSD5	2.38e-05	1105	166	17	35748872
Pubmed	Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.	DNAJC13 PSMD13 HUWE1 RNF17 TRIP12 TUBG1 NCAPG SUPV3L1 DIAPH1 PRKDC CNOT1 EXOC4	2.54e-05	582	166	12	20467437
Pubmed	Impaired plasma membrane localization of ubiquitin ligase complex underlies 3-M syndrome development.	DNAJC13 WDR36 NOP56 MROH2A LAMA5 HUWE1 DNAH1 NUP205 MRPS2 DIAPH1 MROH7	2.88e-05	496	166	11	31343991
Pubmed	Adamts18 Deficiency Causes Spontaneous SMG Fibrogenesis in Adult Mice.	COL3A1 LAMA5 ITGA3 BTBD7	2.92e-05	37	166	4	34323105
Interaction	GPR17 interactions	IPO8 TTI2 TSC2 COG3 URB1 NCAPG INTS2 MTOR PDS5A PRKDC MED23 MFSD5 EXOC4	4.70e-07	283	161	13	int:GPR17
Interaction	TNFSF13B interactions	USP34 IPO8 TSC2 NCAPG MTOR PDS5A TMEM131 MAP3K15 PRKDC	4.84e-07	119	161	9	int:TNFSF13B
Interaction	EFNA4 interactions	NCAPD3 TTI2 ITGA3 COG3 URB1 SIDT2 INTS2 PDE4DIP PDS5A PRKDC SOS1	3.62e-06	239	161	11	int:EFNA4
Interaction	LRRC31 interactions	NCAPD3 DNAJC13 LARP1 FRYL TRIP12 MTOR MROH7 PRKDC HECTD1 CNOT1	6.09e-06	205	161	10	int:LRRC31
Interaction	FPR1 interactions	IPO8 TTI2 COG3 URB1 INTS2 MTOR PDS5A PRKDC	2.43e-05	147	161	8	int:FPR1
Interaction	BTNL9 interactions	USP34 NCAPD3 IPO8 MROH2A NCAPG INTS2 PDS5A MFSD5	3.72e-05	156	161	8	int:BTNL9
Interaction	C3orf18 interactions	NCAPD3 TSC2 NCAPG MTOR PDS5A PRKDC SOS1	3.88e-05	115	161	7	int:C3orf18
Interaction	HECTD1 interactions	NCAPD3 DNAJC13 WDR36 IPO8 NOP56 LARP1 ERI1 HUWE1 TRIP12 NUP205 CCNF URB1 NCAPG POLR3B ARID2 FECH PRKDC MED23 HECTD1 CNOT1 EXOC4	3.88e-05	984	161	21	int:HECTD1
Interaction	OPALIN interactions	NCAPD3 IPO8 TSC2 NUP205 INTS2 MTOR PDS5A PRKDC MAP3K21	4.79e-05	209	161	9	int:OPALIN
Interaction	AP3S2 interactions	HUWE1 SIDT2 SCARB2 HECTD1	6.92e-05	28	161	4	int:AP3S2
Interaction	GPR182 interactions	NCAPD3 IPO8 TTI2 TSC2 COG3 NUP205 SNX14 URB1 MTOR PDS5A PRKDC MED23 EXOC4	7.70e-05	455	161	13	int:GPR182
Interaction	BIN1 interactions	NCAPD3 IPO8 MAP4K3 HUWE1 ITGA3 SOS1 SOS2	8.06e-05	129	161	7	int:BIN1
GeneFamily	Potassium voltage-gated channel subfamily J	KCNJ4 KCNJ5 KCNJ9 KCNJ12 KCNJ18	3.01e-08	16	109	5	276
GeneFamily	Dyneins, axonemal	DNAH1 DNAH9 DNAH11	1.36e-04	17	109	3	536
GeneFamily	Guanylate cyclases, soluble	GUCY1A1 GUCY1B1	2.14e-04	4	109	2	820
GeneFamily	Glutamate ionotropic receptor NMDA type subunits	GRIN2C GRIN2D	7.42e-04	7	109	2	1201
GeneFamily	Cyclins\|F-boxes other	CCNF FBXO24 FBH1	1.66e-03	39	109	3	560
GeneFamily	Maestro heat like repeat containing	MROH2A MROH7	1.91e-03	11	109	2	636
ToppCell	facs-Pancreas-Exocrine-3m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CMTR1 GCGR FRYL ITGAD PROZ MTOR KCNJ5 PDE4DIP FAM135A	1.98e-08	174	166	9	f1fe1f4216748a9562dd03bd48c70b23c7ff4d1d
ToppCell	CV-Moderate-7\|CV / Virus stimulation, Condition and Cluster	WDR36 FRYL HUWE1 ITGAD URB1 ARID2 PRKDC EXOC4	5.07e-07	186	166	8	8571956890fc9894d766ba294a28e376b4aba428
ToppCell	356C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_3\|CD8+_Cytotoxic_T-cell / Donor, Lineage, Cell class and subclass (all cells)	TMEM185B TUBG2 MAB21L4 ITGA3 PDE4DIP DSCC1 CCDC157	3.99e-06	173	166	7	7e2149205e119cec4f5099c83c85d1e13470137a
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MROH2A DSCAML1 DNAH1 DISP3 DNAH9 UNC79 DNAH11	5.99e-06	184	166	7	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MROH2A DSCAML1 DNAH1 DISP3 DNAH9 UNC79 DNAH11	5.99e-06	184	166	7	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MROH2A DSCAML1 DNAH1 DISP3 DNAH9 UNC79 DNAH11	5.99e-06	184	166	7	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	CD8+_Memory_T_cell-CV-7\|CD8+_Memory_T_cell / cell class, Virus stimulation and cluster	WDR36 FRYL HUWE1 URB1 ARID2 PRKDC EXOC4	7.64e-06	191	166	7	9454f642c3621370fa23640b631301346b300950
ToppCell	TCGA-Prostate-Primary_Tumor-Prostate_Adenocarcinoma-Acinar_Adenocarcinoma-6\|TCGA-Prostate / Sample_Type by Project: Shred V9	USP34 FRYL HUWE1 PDS5A PRKDC MED23 HECTD1	8.18e-06	193	166	7	abd71b2cf667ef2b1c4d88acd0c1dd19a12ff659
ToppCell	Sigmoid-Dendritic_cell-cycling_DCs\|Dendritic_cell / Region, Cell class and subclass	NCAPD3 MTFP1 NUP205 NCAPG SCARB2 DSCC1 MFSD5	1.03e-05	200	166	7	372fe9018481a4e9ac6ab3af43705a48238c4376
ToppCell	LPS_only-Epithelial_airway-Ciliated_cells-Ciliated\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DNAH1 HEATR9 DNAH9 CFAP46 DRC3 DNAH11	2.46e-05	154	166	6	9ca71d440c4f87781e6525b8141e7d8d470b6a8e
ToppCell	LPS_only-Epithelial_airway-Ciliated_cells\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DNAH1 HEATR9 DNAH9 CFAP46 DRC3 DNAH11	2.46e-05	154	166	6	58072ce422d09f2de602580325eaac6c4ec6c136
ToppCell	LPS-IL1RA+antiTNF-Epithelial_airway-Ciliated_cells\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DNAH1 HEATR9 DNAH9 CFAP46 DRC3 DNAH11	2.56e-05	155	166	6	5f1e2195a6b831e1b636f5cc3a282ca423721822
ToppCell	LPS-IL1RA+antiTNF-Epithelial_airway-Ciliated_cells-Ciliated\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DNAH1 HEATR9 DNAH9 CFAP46 DRC3 DNAH11	2.56e-05	155	166	6	0944429459f642a1bcc56edc1ec28aaecde3e2dc
ToppCell	10x5'-Lung-Lymphocytic_T_CD4-T_CD4/CD8\|Lung / Manually curated celltypes from each tissue	RNF17 ESYT3 CYP4X1 DNAH9 CFAP46 DNAH11	2.65e-05	156	166	6	10d191e29b16cae8238e8df6c0ff38882253f34e
ToppCell	droplet-Marrow-nan-3m-Lymphocytic-plasma_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL3A1 SASH1 MAP4K3 SLC13A3 ITGAD LRP1	3.06e-05	160	166	6	0544bc465af208da448858d6e174ff56f2e08a46
ToppCell	droplet-Lung-LUNG-1m-Myeloid-dendritic_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DSCAML1 ESYT3 URB1 NECAB3 MAP3K15 DSCC1	3.88e-05	167	166	6	e30e7ac8ea4399dc3c1d94fc6b857afc80a7a671
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.0.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	TDRD1 ODF2L DNAH9 CFAP46 DRC3 DNAH11	4.15e-05	169	166	6	14aadc2d1bf66eb47dac33b4d61ddb3c942caa4f
ToppCell	facs-Diaphragm-Limb_Muscle-24m\|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MROH2A RNF17 DNAH1 DNAH9 UNC79 DNAH11	4.15e-05	169	166	6	12bdc709bc000d7f9061ecd9fbd57233eaacb7e2
ToppCell	3'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CDAN1 GARIN4 ODF2L CCDC157 CFAP46 DRC3	4.58e-05	172	166	6	73e9b29b1c6b8b016b495a0d20336d0c0761e5e2
ToppCell	droplet-Lung-LUNG-1m-Myeloid-Proliferating_Dendritic\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ESYT3 URB1 NECAB3 MAP3K15 DSCC1 DNAH11	4.73e-05	173	166	6	15af4a0f7516dbf5c93ba66a19aca073ebe30d04
ToppCell	droplet-Marrow-nan-18m-Myeloid-basophil\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PIGL MAP4K3 DNAH1 POLR3B SUPV3L1 PDE4DIP	4.88e-05	174	166	6	55cc8300489d11322724159ec7d0e1d32a702e91
ToppCell	5'-Adult-LargeIntestine-Hematopoietic-Myeloid-Lymphoid_DC\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	GCGR GRIN2D ITGAD DSCAML1 RFTN1 DNAH11	4.88e-05	174	166	6	16204ff504b7b382b4d90ca35003ad5336020e07
ToppCell	PBMC_fresh-frozen-Severe-critical_convalescent_d14-21-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c12-MKI67-TYROBP\|Severe-critical_convalescent_d14-21 / Compartment, severity and other cell annotations on 10x 3' data (130k)	PIDD1 MTFP1 TUBG1 ADAMTS10 SLC25A10 DSCC1	5.04e-05	175	166	6	86dfce849b2ec023a72f7e887fa681b117155e51
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SASH1 DOCK11 LRRK2 DSCAML1 CCDC198 DNAH11	5.20e-05	176	166	6	327a3e81b724252e36d786de92a3ffd721ea6d7b
ToppCell	Entopeduncular-Macroglia-POLYDENDROCYTE-P3-Tnr-Polydendendrocytes_NG2_cells_(Tnr-Cspg5)\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	MROH2A RNF17 NCAPG DSCC1 DNAH11	5.52e-05	109	166	5	87f647cfebbb7de725e434cc27058e1c6accbb90
ToppCell	Entopeduncular-Macroglia-POLYDENDROCYTE-P3-Tnr\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	MROH2A RNF17 NCAPG DSCC1 DNAH11	5.52e-05	109	166	5	e3696d84da1dcd15f15d0434ea9d1955f2af22d6
ToppCell	Entopeduncular-Macroglia-POLYDENDROCYTE-P3-Tnr-Polydendendrocytes_NG2_cells_(Tnr-Cspg5)-\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	MROH2A RNF17 NCAPG DSCC1 DNAH11	5.52e-05	109	166	5	6678036ff66c825a18d2506e33be421c27cf82e1
ToppCell	Entopeduncular-Macroglia-POLYDENDROCYTE-P3\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	MROH2A RNF17 NCAPG DSCC1 DNAH11	5.52e-05	109	166	5	c9d1e69f9841135f4d114563a293a69a8ba5f965
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	DOCK11 LRRK2 DSCAML1 OPHN1 CCDC198 DNAH11	5.54e-05	178	166	6	c20f050344a2e120e685e2a7fe36c6dfc1dc37b6
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_2\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CNNM2 MAP4K3 OPHN1 ME3 ITPR1 MAP3K15	5.71e-05	179	166	6	666072c0e8448dbaec1683d18368ec2502453f90
ToppCell	5'-Airway_Nasal-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell-Multiciliated_(nasal)-Multiciliated_(nasal)_L.0.3.1.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SLC13A3 DNAH9 CCDC157 CFAP46 DRC3 DNAH11	5.89e-05	180	166	6	1f1af4474f3f0ac3c0d6b1a6c875c354d36d8eec
ToppCell	3'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.3.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	KCNRG DNAH1 ODF2L CFAP46 DRC3 DNAH11	5.89e-05	180	166	6	92fb01b91261b3103454924cde56add337b41844
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SASH1 DOCK11 LRRK2 DSCAML1 CCDC198 DNAH11	6.26e-05	182	166	6	5e1b316599436740f1b30875f0ebd33c3edfb2b6
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_2\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CNNM2 CEL MAP4K3 GCGR OPHN1 ITPR1	6.46e-05	183	166	6	2f0ee40e69ad1259e56e8ee4b352736900eb8901
ToppCell	18-Airway-Epithelial-Multiciliated_precursor\|Airway / Age, Tissue, Lineage and Cell class	ST7 MTFP1 TUBG1 CCDC157 CFAP46 DRC3	6.46e-05	183	166	6	a75cda2131755931117c387f2e0ae3394efa8e80
ToppCell	367C-Epithelial_cells-Epithelial-F_(Ciliated)-\|367C / Donor, Lineage, Cell class and subclass (all cells)	KCNRG DNAH9 SPATA4 CFAP46 DRC3 DNAH11	6.46e-05	183	166	6	b1336eac5adbffade4cef3e0ce3de75a781ae365
ToppCell	367C-Epithelial_cells-Epithelial-F_(Ciliated)\|367C / Donor, Lineage, Cell class and subclass (all cells)	KCNRG DNAH9 SPATA4 CFAP46 DRC3 DNAH11	6.46e-05	183	166	6	cc57dcb59c68d68a546dc108dd9e009b2aab8da5
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_2\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CNNM2 MAP4K3 OPHN1 ME3 ITPR1 MAP3K15	6.46e-05	183	166	6	2e831a4d99c6f983793df71c0994124c943c6da9
ToppCell	CV-Moderate-7\|Moderate / Virus stimulation, Condition and Cluster	WDR36 FRYL HUWE1 URB1 PRKDC EXOC4	6.86e-05	185	166	6	a6c9203ce6c2892a4a369c9bcfb85720f01cbb3f
ToppCell	NS-moderate-d_16-33-Epithelial-Ciliated\|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	SLC13A3 KCNRG DNAH9 CFAP46 DRC3 DNAH11	6.86e-05	185	166	6	5e689c2fb36ce3ac2adc8d15f67107f21cf68868
ToppCell	Globus_pallidus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2.Cadm2_(Cadm2+_state)\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	ADTRP TDRD1 KCNRG TYRP1	6.94e-05	59	166	4	b2c10c4c0a750d7f49f5a813ab5d103fb07ca76b
ToppCell	Globus_pallidus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2.Cadm2_(Cadm2+_state)-\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	ADTRP TDRD1 KCNRG TYRP1	6.94e-05	59	166	4	bcac768e1e034e27bab7cad3c2bf09a8f0a819ad
ToppCell	Globus_pallidus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2.Cadm2_(Cadm2+_state)--\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	ADTRP TDRD1 KCNRG TYRP1	6.94e-05	59	166	4	f9b9464f4d786991aad01b47e2a8fd33f889c2e2
ToppCell	NS-moderate-d_07-13-Epithelial-Ciliated\|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	SLC13A3 KCNRG DNAH9 CFAP46 DRC3 DNAH11	7.06e-05	186	166	6	85787ff207f109ec7e3c0f729ba9bda739c2fdc9
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SASH1 DOCK11 LRRK2 DSCAML1 CCDC198 DNAH11	7.49e-05	188	166	6	63a4b25a0a6e05f80f1a6dd91b817f3cf49e6b68
ToppCell	facs-Trachea-24m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l32-30\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	LRRK2 FRYL MORC4 OPHN1 CCDC198 KCNJ12	7.49e-05	188	166	6	c2febf9fd4632af1f922067c3a30e5c50f75f480
ToppCell	ASK428-Epithelial-Ciliated\|ASK428 / Donor, Lineage and Cell class of Lung cells from Dropseq	KCNRG ODF2L DNAH9 CFAP46 DRC3 DNAH11	8.18e-05	191	166	6	0c4b926a28bc94f3cf4d68a911c0a189f6ff505e
ToppCell	COVID-19-lung-Macrophage_PPARGhi_CD5Lhi\|lung / Disease (COVID-19 only), tissue and cell type	DOCK11 ARRDC4 ADTRP PARVG PDE4DIP LRP1	8.18e-05	191	166	6	dab953682b8c9ed680a799161f837f792a7e4f33
ToppCell	droplet-Bladder-nan-3m-Epithelial-nan\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	THEMIS KCP DNAH1 GARIN4 MED23	8.37e-05	119	166	5	018162114bc22a9780fded5887f1f78211851700
ToppCell	ASK428-Epithelial-Ciliated\|Epithelial / Donor, Lineage and Cell class of Lung cells from Dropseq	KCNRG ODF2L DNAH9 CFAP46 DRC3 DNAH11	8.41e-05	192	166	6	356ebddd03aec341b79890977edb8ff0804999a1
ToppCell	NS-critical-d_07-13-Epithelial-Ciliated\|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	KCNRG DNAH9 SPATA4 CFAP46 DRC3 DNAH11	8.91e-05	194	166	6	1ae8a10e508e672e6677f0e3c986ac30d05adeb3
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Vascular-Mural_cell-SMC_prolif-G\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	COL3A1 RECQL SYDE1 NCAPG GUCY1A1 GUCY1B1	8.91e-05	194	166	6	78dcb9d48259afabe73b41c5508a73a8d62339a4
ToppCell	moderate-Epithelial-Ciliated\|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	SLC13A3 KCNRG DNAH9 CFAP46 DRC3 DNAH11	9.16e-05	195	166	6	3486eae5fdb062a75a907b896c9d7b396d2aa195
ToppCell	moderate-Epithelial-Ciliated\|moderate / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	SLC13A3 KCNRG DNAH9 CFAP46 DRC3 DNAH11	9.16e-05	195	166	6	e80f5cdf0b18066b3e6c2f5452e58f101c67932c
ToppCell	distal-Hematologic-Platelet/Megakaryocyte-3\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	KCNRG CYP4X1 DNAH9 SPATA4 DRC3 DNAH11	9.69e-05	197	166	6	751ffb8792058384079ebfe94872b3525f1aea84
ToppCell	distal-Hematologic-Platelet/Megakaryocyte\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	KCNRG CYP4X1 DNAH9 SPATA4 DRC3 DNAH11	9.69e-05	197	166	6	e28b1b154d9588dce07c123b36f7f01fa90a5fc1
ToppCell	Bronchial-NucSeq-Immune_Myeloid-Macrophage_other-Macro_CHIT1\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	SIGLEC8 ADTRP ITGAD PARVG KCNJ5 LRP1	9.96e-05	198	166	6	0b41b3d6c2db795320e8b65d40d85fb8b618cc34
ToppCell	distal-Epithelial-Ciliated\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	KCNRG DNAH9 SPATA4 CFAP46 DRC3 DNAH11	1.02e-04	199	166	6	18ca031cfe702afb9bf94e03c0f3680c38e7599e
ToppCell	proximal-Epithelial-Ciliated\|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	KCNRG DNAH9 SPATA4 CFAP46 DRC3 DNAH11	1.02e-04	199	166	6	9700f06e51ddca85e482b4f9bd4a79bfcd3cfb76
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-OPC-OPC-G\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	GABRB3 LRRK2 OPHN1 LRP1 UNC79 CDH10	1.02e-04	199	166	6	19a97e27a4758e794ce7246d295e112b47931a48
ToppCell	proximal-3-Epithelial-Ciliated\|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	KCNRG DNAH9 SPATA4 CFAP46 DRC3 DNAH11	1.02e-04	199	166	6	1188afad6fd5f01f9aeba225f611f38b237dd2c9
ToppCell	distal-3-Epithelial-Ciliated\|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	KCNRG DNAH9 SPATA4 CFAP46 DRC3 DNAH11	1.02e-04	199	166	6	7e5f29f4ec1fea92f2c0064eea151d2d474ef904
ToppCell	distal-Epithelial-Ciliated-3\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	KCNRG DNAH9 SPATA4 CFAP46 DRC3 DNAH11	1.02e-04	199	166	6	6ce0df4a6f4d9353919e26ffab97c9ec89911da6
ToppCell	proximal-Epithelial-Ciliated-3\|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	KCNRG DNAH9 SPATA4 CFAP46 DRC3 DNAH11	1.02e-04	199	166	6	2e8ace105c4e2405baa06d953e52888b54e2d055
ToppCell	Tracheal-10x5prime-Epithelial-Epi_airway_ciliated\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	DNAH1 DNAH9 SPATA4 CFAP46 DRC3 DNAH11	1.05e-04	200	166	6	31d75c26055177d656df1fbb10b764cebd61e122
ToppCell	Parenchymal-10x3prime_v2-Epithelial-Epi_airway_ciliated\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	KCNRG DNAH9 SPATA4 CFAP46 DRC3 DNAH11	1.05e-04	200	166	6	5abd6d81e1cc354484ae693fcd708d78926e75b5
ToppCell	Tracheal-10x5prime-Epithelial-Epi_airway_ciliated-Ciliated\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	DNAH1 DNAH9 SPATA4 CFAP46 DRC3 DNAH11	1.05e-04	200	166	6	e1dce91c6c531bb212002a14705e496d77ad3490
ToppCell	Parenchymal-10x3prime_v2-Epithelial-Epi_airway_ciliated-Ciliated\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	KCNRG DNAH9 SPATA4 CFAP46 DRC3 DNAH11	1.05e-04	200	166	6	9c9d2b0276c7b0709c2eeeb0673a2f58106fb14e
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-OPC-OPC-F\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	GABRB3 WSCD1 OPHN1 LRP1 CDH10 PLXNB3	1.05e-04	200	166	6	ad777683adeb2ce45ade570386235e311fa7ea2d
ToppCell	Control_saline-Mesenchymal_myocytic-Pericyte\|Control_saline / Treatment groups by lineage, cell group, cell type	CNNM2 DOCK11 KCP RFTN1 GUCY1B1 LRP1	1.05e-04	200	166	6	cb7ef774b6d300f8019c5b16a04e3ebd165e4f1c
ToppCell	LPS_only-Mesenchymal_myocytic-Pericyte-Pericyte_2\|LPS_only / Treatment groups by lineage, cell group, cell type	CNNM2 DOCK11 KCP GCGR RFTN1 GUCY1B1	1.05e-04	200	166	6	69edc375d85689300d1dbc1217fedc40063ecdcb
ToppCell	Control_saline-Mesenchymal_myocytic-Pericyte-Pericyte_2\|Control_saline / Treatment groups by lineage, cell group, cell type	DOCK11 MAP4K3 KCP RFTN1 GUCY1B1 LRP1	1.05e-04	200	166	6	bc8949eb34482aca166c4602ff6ab876cb4c2c3c
ToppCell	-IPF_04\|World / lung cells shred on cell class, cell subclass, sample id	COL3A1 CEL CILP ADAMTS10 TYRP1	1.18e-04	128	166	5	dab10774bc0532a1664fd8ac2b54cffab01be55a
ToppCell	Posterior_cortex-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	TYRP1 SPATA21 KCNJ5 SPATA4	1.28e-04	69	166	4	4831573a45ace5f06cd409f0e75bce838ed65a88
ToppCell	droplet-Heart-nan-24m-Hematologic-erythrocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NUP210L PIDD1 PROZ FECH	1.60e-04	73	166	4	30374f4d30519ca8cd9582da1f9f906420e50244
Drug	baclofen	GABRB3 GRIN2C GRIN2D PKD1L3 ITPR1 KCNJ4 KCNJ5 KCNJ9 KCNJ12	1.11e-05	191	165	9	CID000002284
Drug	(-)-Eseroline fumarate salt [104015-29-4]; Up 200; 12uM; MCF7; HT_HG-U133A	USP34 CNNM2 IPO8 SASH1 ST7 RECQL NPHS2 CCDC198 SOS1	1.36e-05	196	165	9	7027_UP
Drug	Spectinomycin dihydrochloride [21736-83-4]; Up 200; 9.8uM; MCF7; HT_HG-U133A	WSCD1 PLEKHF1 CLEC1A BCL3 SYDE1 PROZ ACTL8 KCNJ9 SOS2	1.36e-05	196	165	9	4773_UP
Drug	Vincamine [1617-90-9]; Down 200; 11.2uM; MCF7; HT_HG-U133A	KIAA0930 IPO8 TDRD1 SYDE1 TYRP1 SIDT2 CSF1 ACTL8 SCARB2	1.42e-05	197	165	9	3865_DN
Drug	Gentamicine sulfate [1405-41-0]; Down 200; 2.6uM; PC3; HT_HG-U133A	MYL4 BCL3 ITPR1 CCNF SIDT2 BTBD7 PDE4DIP PDS5A SOS1	1.42e-05	197	165	9	2082_DN
Drug	Chlorambucil [305-03-3]; Up 200; 13.2uM; PC3; HT_HG-U133A	BCL3 HUWE1 SIDT2 CCDC198 ACTL8 KCNJ4 KCNJ5 ADAM2 FAM135A	1.48e-05	198	165	9	3788_UP
Drug	sodium 4-phenylbutyrate; Up 200; 1000uM; PC3; HG-U133A	KIAA0930 MYL4 CLEC1A SLC13A3 RNF17 ME3 KCNJ5 PDS5A CDH10	1.48e-05	198	165	9	434_UP
Drug	Clebopride maleate [84370-95-6]; Up 200; 8.2uM; MCF7; HT_HG-U133A	IPO8 ITPR1 URB1 CSF1 GUCY1A1 KCNJ4 KCNJ5 FECH SOS2	1.54e-05	199	165	9	5412_UP
Drug	SKF 10,047	GRIN2C GRIN2D KCNRG TMBIM4	4.10e-05	27	165	4	CID000001235
Drug	pinacidil	GUCY1B1 KCNJ4 KCNJ5 KCNJ9 KCNJ12 MED23	4.11e-05	87	165	6	CID000004826
Drug	A13108	KCNJ4 KCNJ5 KCNJ12	4.32e-05	10	165	3	CID000062278
Drug	cromakalim	GUCY1B1 KCNJ4 KCNJ5 KCNJ9 KCNJ12 MED23	4.39e-05	88	165	6	CID000071191
Drug	diethylamine dinitric oxide adduct	GUCY1A1 GUCY1B1	5.22e-05	2	165	2	ctd:C087229
Drug	dicyanocobinamide	GUCY1A1 GUCY1B1	5.22e-05	2	165	2	ctd:C513735
Drug	3-(2-(2,2-dimethylpropylsulfanyl)pyridin-3-yl)-N-(3-hydroxycyclohexyl)acrylamide	GUCY1A1 GUCY1B1	5.22e-05	2	165	2	ctd:C515661
Drug	5-chloro-2-(5-chlorothiophene-2-sulfonylamino)-N-(4-(morpholine-4-sulfonyl)phenyl)benzamide	GUCY1A1 GUCY1B1	5.22e-05	2	165	2	ctd:C515616
Drug	3-(2-(4-chlorophenylsulfanyl)phenyl)-N-(4-dimethylaminobutyl)acrylamide	GUCY1A1 GUCY1B1	5.22e-05	2	165	2	ctd:C470768
Drug	CID5255110	KCNJ4 KCNJ5 KCNJ9 KCNJ12 SLC25A10	5.81e-05	57	165	5	CID005255110
Drug	Spiperone [749-02-0]; Down 200; 10.2uM; PC3; HT_HG-U133A	WSCD1 MYL4 IPO8 SASH1 PIDD1 SYDE1 GUCY1A1 GUCY1B1	6.57e-05	186	165	8	5777_DN
Drug	Butylparaben [94-26-8]; Down 200; 20.6uM; MCF7; HT_HG-U133A	KIAA0930 MYL4 MAB21L4 PIDD1 ADTRP RFTN1 URB1 SOS2	8.51e-05	193	165	8	5608_DN
Drug	Nalbuphine hydrochloride [23277-43-2]; Up 200; 10.2uM; MCF7; HT_HG-U133A	COL3A1 MYL4 CILP SIGLEC8 ADTRP SYDE1 KCNJ4 DNAH9	9.14e-05	195	165	8	2225_UP
Drug	Homosalate [118-56-9]; Down 200; 15.2uM; PC3; HT_HG-U133A	USP34 KIAA0930 TUBG2 PLEKHF1 TSC2 CCNF URB1 CDH10	9.14e-05	195	165	8	4533_DN
Drug	S(-)Eticlopride hydrochloride [97612-24-3]; Up 200; 10.6uM; PC3; HT_HG-U133A	USP34 SIGLEC8 PLEKHF1 SIDT2 KCNJ5 PDE4DIP LRP1 PDS5A	9.14e-05	195	165	8	4634_UP
Drug	Metronidazole [443-48-1]; Up 200; 23.4uM; MCF7; HT_HG-U133A	COL3A1 WSCD1 MYL4 BCL3 RNF17 NPHS2 CSF1 CDH10	9.14e-05	195	165	8	4141_UP
Drug	Lumicolchicine gamma [6901-14-0]; Down 200; 10uM; MCF7; HT_HG-U133A	USP34 KIAA0930 CNNM2 PLEKHF1 LAMA5 PIDD1 TDRD1 MTOR	9.14e-05	195	165	8	3254_DN
Drug	Guanosine Triphosphate	CSF1 GUCY1A1 GUCY1B1 SOS1	9.24e-05	33	165	4	ctd:D006160
Drug	Y-27632; Up 200; 3uM; MCF7; HT_HG-U133A_EA	USP34 PIGL KIAA0930 IPO8 ME3 RFTN1 CCDC198 BTBD7	9.47e-05	196	165	8	832_UP
Drug	Tomatidine [77-59-8]; Up 200; 9.6uM; MCF7; HT_HG-U133A	MYL4 SIGLEC8 PLEKHF1 SLC13A3 SYDE1 ITPR1 URB1 GUCY1A1	9.81e-05	197	165	8	2746_UP
Drug	Nimodipine [66085-59-4]; Down 200; 9.6uM; PC3; HT_HG-U133A	MYL4 PSMD13 SIDT2 KBTBD4 GUCY1A1 SCARB2 PDE4DIP SOS2	9.81e-05	197	165	8	6320_DN
Drug	Norfloxacin [70458-96-7]; Up 200; 12.6uM; HL60; HG-U133A	PIGL SCYL3 PIDD1 TSC2 BCL3 KBTBD4 PDS5A SOS1	1.05e-04	199	165	8	1406_UP
Drug	Gliquidone [33342-05-1]; Up 200; 7.6uM; MCF7; HT_HG-U133A	MYL4 CEL PLEKHF1 CSF1 BTBD7 FAM135A CDH10 DRC3	1.05e-04	199	165	8	6004_UP
Drug	Adenosine 5'-monophosphate monohydrate [18422-05-4]; Up 200; 11uM; MCF7; HT_HG-U133A	USP34 PIGL KIAA0930 MYL4 IPO8 TUBG2 BCL3 RFTN1	1.05e-04	199	165	8	5359_UP
Drug	Bretylium tosylate [61-75-6]; Down 200; 9.6uM; PC3; HT_HG-U133A	KIAA0930 CNNM2 URB1 NPHS2 CCDC198 PDE4DIP PDS5A SOS2	1.05e-04	199	165	8	6674_DN
Drug	Probucol [23288-49-5]; Down 200; 7.8uM; HL60; HG-U133A	MYL4 SCYL3 RECQL PSMD13 ITPR1 URB1 KBTBD4 MFSD5	1.09e-04	200	165	8	1608_DN
Drug	Thonzonium bromide [553-08-2]; Down 200; 6.8uM; HL60; HT_HG-U133A	CMTR1 TUBG2 ST7 URB1 BTBD7 FECH NECAB3 PDS5A	1.09e-04	200	165	8	3080_DN
Disease	complex cortical dysplasia with other brain malformations 4 (implicated_via_orthology)	TUBG2 TUBG1	3.07e-05	2	164	2	DOID:0090138 (implicated_via_orthology)
Disease	Focal Cortical Dysplasia of Taylor, Type IIb	TSC2 MTOR	9.18e-05	3	164	2	C1846389
Disease	FOCAL CORTICAL DYSPLASIA OF TAYLOR	TSC2 MTOR	9.18e-05	3	164	2	C1846385
Disease	Focal Cortical Dysplasia of Taylor, Type IIa	TSC2 MTOR	9.18e-05	3	164	2	C1846386
Disease	Isolated focal cortical dysplasia type II	TSC2 MTOR	9.18e-05	3	164	2	cv:C1846385
Disease	FOCAL CORTICAL DYSPLASIA, TYPE II	TSC2 MTOR	9.18e-05	3	164	2	607341
Disease	Primary Ciliary Dyskinesia	DNAH1 DNAAF2 DNAH9 DNAH11	1.36e-04	47	164	4	C4551720
Disease	developmental disorder of mental health (implicated_via_orthology)	GABRB3 GRIN2C GRIN2D PLXNB3	1.60e-04	49	164	4	DOID:0060037 (implicated_via_orthology)
Disease	Squamous cell carcinoma of lung	MAP4K3 MAP3K15 PRKDC	7.43e-04	32	164	3	C0149782
Disease	uterine fibroid	COL3A1 THEMIS PSMD13 ITPR1 GUCY1A1 GUCY1B1	8.90e-04	199	164	6	EFO_0000731
Disease	Primary ciliary dyskinesia	DNAH1 DNAAF2 DNAH11	1.05e-03	36	164	3	cv:C0008780
Disease	Osteitis Deformans	NUP205 CSF1	1.08e-03	9	164	2	C0029401
Disease	Nerve Degeneration	LRRK2 TSC2 GRIN2D KCNJ4	1.20e-03	83	164	4	C0027746
Disease	4-vinylphenol sulfate measurement	GABRB3 SOS2	1.34e-03	10	164	2	EFO_0021149
Disease	Conventional (Clear Cell) Renal Cell Carcinoma	LRRK2 PIDD1 TSC2 MTOR RNF139	1.46e-03	148	164	5	C0279702
Disease	cystatin C measurement	CCNI2 HECTD4 KCP DNAH1 CSF1 SCARB2 LRP1 SOS1	1.91e-03	402	164	8	EFO_0004617
Disease	Alzheimer disease, dementia	POLR3B CFAP46	1.95e-03	12	164	2	MONDO_0001627, MONDO_0004975
Disease	epilepsy (implicated_via_orthology)	SLC13A3 GRIN2C GRIN2D ITGA3 LRP1	2.22e-03	163	164	5	DOID:1826 (implicated_via_orthology)
Disease	fatty acid measurement, fetal genotype effect measurement, breast milk measurement	COG3 FAM135B	2.30e-03	13	164	2	EFO_0005110, EFO_0007959, EFO_0009092
Disease	Malformations of Cortical Development	TUBG1 MTOR	2.67e-03	14	164	2	C1955869
Disease	fatty acid measurement, breast milk measurement, parental genotype effect measurement	COG3 FAM135B	2.67e-03	14	164	2	EFO_0005110, EFO_0005939, EFO_0009092
Disease	Cortical Dysplasia	TUBG1 MTOR	2.67e-03	14	164	2	C0431380
Disease	autoimmune disease	MYL4 SASH1 CEL KCP TMEM131	2.87e-03	173	164	5	EFO_0005140
Disease	Metastatic melanoma	MTOR MAP3K15 PRKDC	3.40e-03	54	164	3	C0278883
Disease	pancreatitis	HECTD4 MORC4	3.50e-03	16	164	2	EFO_0000278
Disease	proprotein convertase subtilisin/kexin type 7 measurement	DSCAML1 SIDT2	3.95e-03	17	164	2	EFO_0008270
Disease	pulse pressure measurement	USP34 CNNM2 MYL4 TTI2 LAMA5 FRYL PKD1L3 ODF2L SENP1 GUCY1A1 OTUD6B LRP1 BRD1 CNOT1 CCDC157 SOS2	4.82e-03	1392	164	16	EFO_0005763
Disease	Noonan-Like Syndrome With Loose Anagen Hair	SOS1 SOS2	4.93e-03	19	164	2	C3501846
Disease	Phenyllactate (PLA) measurement	IPO8 CNOT1	4.93e-03	19	164	2	EFO_0021662
Disease	Noonan syndrome-like disorder with loose anagen hair	SOS1 SOS2	4.93e-03	19	164	2	C1843181
Disease	Cardio-facio-cutaneous syndrome	SOS1 SOS2	4.93e-03	19	164	2	C1275081
Disease	Costello syndrome (disorder)	SOS1 SOS2	4.93e-03	19	164	2	C0587248

Protein segments in the cluster

Peptide	Gene	Start	Entry
PRIISDVLIDEHLVL	TDRD1	881	Q9BXT4
ILVLKRDLPFVTHTL	CASTOR3	136	Q8NAP1
IIEFPVVLLNTHTLE	ERI1	151	Q8IV48
LLEDLIATHLVLPNR	ESYT3	271	A0FGR9
GRLHRISIFDPLEII	BRD1	46	O95696
AAVAVFTTHILLLLP	DISP3	1196	Q9P2K9
PLITDHSREVLEQLV	AMN1	231	Q8IY45
EILFELLHVPSVLLA	ACTL8	116	Q9H568
VLHPRTISLESLAVI	ADAM2	296	Q99965
EATLRHPSIIFIDEL	SPATA5	441	Q8NB90
AELLRALPAETHVVV	ACTL9	356	Q8TC94
LVRERDLPFVTHTLS	CASTOR2	126	A6NHX0
HTFIFPITLAEVVLR	ADTRP	131	Q96IZ2
HLTLPDVLLVISTLE	ARID2	406	Q68CP9
TPLDFLTIFHALVVL	CCNI2	251	Q6ZMN8
DPLVELQTLTRLTHF	CFAP46	931	Q8IYW2
PLELDFLLRFTVEHT	DNAH11	3801	Q96DT5
IPVIHRLQLIDDAFS	LVRN	681	Q6Q4G3
LITPAEELDFRVHIR	DIAPH1	321	O60610
IRLIPHTVLTFVFLE	SLC25A10	261	Q9UBX3
VLFLVPTEIALAQHR	CEL	411	P19835
PEFTQLSHAVLLELV	CCDC157	66	Q569K6
LVEFLSFADHVVPLL	CDAN1	696	Q8IWY9
LHILGSIRDSVVEIL	ACTR10	256	Q9NZ32
LILLTEDQPTLEITH	ADAMTS10	291	Q9H324
HVLLEASEPVALRAL	ARRDC4	41	Q8NCT1
LQILLPHFSDAREVV	MROH7	1086	Q68CQ1
EAELVTHSVELLLPL	ODF2L	56	Q9ULJ1
THSVELLLPLFKDTI	ODF2L	61	Q9ULJ1
ATLLPEHIVVRSLEE	PARVG	56	Q9HBI0
VKFLLERIAPVHIDS	PDS5A	611	Q29RF7
EREKTPLEHIFRAIL	RFTN1	91	Q14699
IVEPVLAFLHSLFIS	OPHN1	196	O60890
DDRLFLVSPLVISHE	KCNJ9	236	Q92806
TLLLIGHLERVTVEA	NUP205	246	Q92621
DRIFLVSPIIIVHEI	KCNJ4	251	P48050
DRLFLVSPLIISHEI	KCNJ5	266	P48544
NVLLTVLERVHALDP	MAB21L4	41	Q08AI8
LLHSQERLVSLEPVI	C22orf46	196	C9J442
LPITLIASFHRVQAL	LARP1	436	Q6PKG0
PFVTQHLTRSLAIEL	MAP4K3	271	Q8IVH8
VVHEDLRLLLETHLP	NOP56	71	O00567
SVRTFVHESPALILL	TMBIM4	61	Q9HC24
RIFLVSPITILHEID	KCNJ12	261	Q14500
AELLRTVSPELILDH	FAAP20	41	Q6NZ36
ELSVLVDVLHRPELL	ITPR1	1631	Q14643
HELVITIELPLLRSA	DNAAF2	281	Q9NVR5
LLPLRFVRISVQDHE	GARIN4	121	Q8IYT1
FRNLVDPITHDLIIS	LRRC75A	101	Q8NAA5
IVFPHGITLDLVSRL	LRP1	366	Q07954
YVTLPLHRILTDILE	KIAA0930	381	Q6ICG6
FLEVITLHEELRILL	FAM135A	321	Q9P2D6
LFLLTLIHTLEEQPS	PLXNB3	1381	Q9ULL4
LLIAFEVIGVTLHTR	ITGA3	716	P26006
FLSPEVLRLLEVHVK	FAM205A	286	Q6ZU69
FLSPEVLRLLEVHVK	FAM205BP	16	Q63HN1
HSSFLVEDLIRISRP	DBX1	36	A6NMT0
FIVREVTDVHPTLLD	FRYL	621	O94915
TLTLIPLLGVHEVVF	GCGR	351	P47871
LLPIVDVAEALLHVR	INTS2	191	Q9H0H0
VFDIVIHRFLELLPV	MED23	966	Q9ULK4
IHRFLELLPVSKSLE	MED23	971	Q9ULK4
DLRLQTLEIPFHEIV	NPHS2	166	Q9NP85
TSLPVQLEALRAILH	LRRK2	496	Q5S007
IIIHPIDRSVDFLLD	MTFP1	136	Q9UDX5
IELPQFSIVEHRLVS	GABRB3	206	P28472
SDIPLHDATRDLVLL	GUCY1B1	341	Q02153
ILDFLRTHQLLLPTE	KCNRG	61	Q8N5I3
LDFETFLPILQHISR	MYL4	111	P12829
EFEHRVNPLSLVEII	PSMD13	66	Q9UNM6
ELEVRPLAVTGLIFH	LAMA5	3546	O15230
IIILIFLDSRLHTPM	OR2D3	61	Q8NGH3
PAIRDITLEHLQLLS	HECTD4	2471	Q9Y4D8
FTPLVTLLLRHIIED	HUWE1	1816	Q7Z6Z7
FVIIPQLLVHLLSDT	OR10T2	76	Q8NGX3
EDVVSPIILHLNFSL	ITGAD	721	Q13349
SRVIPVLLQLFEVHE	SCYL3	336	Q8IZE3
LRALSHILQTPIEII	OTUD6B	231	Q8N6M0
LHEPLVEELRATIAS	DNAH1	721	Q9P2D7
ITVIFHPLLRFIQEI	EXOC4	496	Q96A65
VLESIERLPLHLYDT	HECTD1	971	Q9ULT8
TVENIVLPRHEALLF	FBH1	1026	Q8NFZ0
ALVDRHSRPEIIFLL	DSCC1	311	Q9BVC3
HSRPEIIFLLKVDDL	DSCC1	316	Q9BVC3
LLLAIIPHVTIRYAE	DOCK11	1001	Q5JSL3
SVFHLLVPSVILVLL	CSF1	496	P09603
TILSLPEDVLFHILK	CCNF	31	P41002
RHEISTYLLPVVISD	CDH10	556	Q9Y6N8
ILPNSSLLIRHVLEE	DSCAML1	746	Q8TD84
RPLIIHVIHLETLSE	COG3	411	Q96JB2
LLILREQIAPFHTEF	COG3	616	Q96JB2
VTIALILLHFRVTPD	CYP4X1	466	Q8N118
EILSSLLPFVRIEHI	BTBD7	511	Q9P203
HIIQLLLTFDPILVE	DNAJC13	1086	O75165
LVEHIISFLPVRDLV	FBXO24	46	O75426
RHIPDEIFLLTAEQI	ME3	506	Q16798
PEDVLDVHLAFLRLL	COL3A1	1346	P02461
SDDIISLALHPERVL	EML5	61	Q05BV3
EHLAALFSEVVLPVL	DNAH9	131	Q9NYC9
HLSSLSAIREELELP	DRC3	331	Q9H069
VPINDAVVFRVHLLL	FAM135B	81	Q49AJ0
LLVPIAFTSDHIETL	FECH	331	P22830
LHLAVITTLPSVVRL	BCL3	176	P20749
FDIPLEHRETSIIKR	CCDC198	81	Q9NVL8
FLPVLAELAIRLRVH	SLC13A3	491	Q8WWT9
LDVILLVFVLSSIHP	METTL8	271	Q9H825
LFTVVRHDAELRVPS	MFSD5	426	Q6N075
LPRDTLLSVEIVHEL	CMTR1	631	Q8N1G2
IRLLVLENIFLIPSH	NUP210L	246	Q5VU65
RDVLDLVPRHSEVFL	NUP210L	1221	Q5VU65
LLQVEFLRLSTHEDP	PIDD1	61	Q9HB75
APSLLRIIVSDHVEF	IPO8	36	O15397
HAAVLVLRELAISVP	MTOR	166	P42345
AEILSAILVHLPVVD	MROH2A	1121	A6NES4
AAVTILIPELRAHFE	MAP3K15	1126	Q6ZN16
LITELPLHIRETLLF	RNF139	166	Q8WU17
SQHIIPLEEVTLELL	PLEKHF1	76	Q96S99
LPDVERATLTLLLDH	SYDE1	521	Q6ZW31
RIFLVSPITILHEID	KCNJ18	261	B7U540
LLPTLAFLVDVRHVS	SLC18A3	401	Q16572
LPFLVLLVASVESHL	SIDT2	6	Q8NBJ9
TLHPIEIARQLTLLE	SOS2	776	Q07890
SLDGHTLILIPEVLL	PRR23A	91	A6NEV1
NPHTLLFEILSLLVE	SPATA21	306	Q7Z572
VVPLLTFEVLLVHRL	TMEM185B	221	Q9H7F4
HIRPSFALILEQLTA	MAP3K21	386	Q5TCX8
DLPLSLLHTQDVLFV	PIGL	196	Q9Y2B2
TFIIHVPELALIRFV	PLCZ1	541	Q86YW0
SVAVHFIELIPTVLR	SLC22A10	451	Q63ZE4
EEFLHLPHRLLTDII	KBTBD4	181	Q9NVX7
EPLLYVELRGHTVIL	KCP	1301	Q6ZWJ8
YLLTSVLPHLELREI	MORC4	901	Q8TE76
ELLVSIHTAVILFPI	PKD1L3	946	Q7Z443
VDVFSVDILLVPIHL	SENP1	516	Q9P0U3
LSVFVTALTHRPDIL	SIGLEC8	146	Q9NYZ4
KDEILSLIHVFRPDI	SCARB2	181	Q14108
LVLVLALHRVEPSVF	PROZ	11	P22891
FSAELIQHIPLSLRV	SUPV3L1	556	Q8IYB8
SFIEQVSVSHLRPLL	ST7	91	Q9NRC1
TVRLPDLIIFLHTLN	MRPS2	186	Q9Y399
IETFDLLTLHPIEIA	SOS1	771	Q07889
LEEVLVAILRHPTLE	URB1	1006	O60287
REVTLALLSLPETHL	URB1	1121	O60287
LDTVLLHTLQRDPVL	URB1	1196	O60287
FTLHVPQDTERLVLT	CILP	526	O75339
LFHIIIDVTSPRSRD	CLEC1A	221	Q8NC01
IPISLVSFLVERLLH	NCAPG	436	Q9BPX3
IPHRVFTLDVVLALL	NCAPD3	406	P42695
GIRTSDIIILPHIIL	CNNM2	151	Q9H8M5
LRVLLVLLHDFPEFL	CNOT1	2096	A5YKK6
TLPREDLEKIIAHFL	RECQL	536	P46063
SPTRLFVHEVALIQI	RNF17	501	Q9BXT8
PEILIEEVYTLLTHR	SPATA4	141	Q8NEY3
EEFVHSLDLRTLPRV	THEMIS	6	Q8N1K5
HPLFVIATRRSEEIL	TYRP1	156	P17643
LADPDTVNHLLIIFI	SNX14	286	Q9Y5W7
LLDLEPRVIHSILNS	TUBG1	66	P23258
LSQHLERVLPASLVI	TTI2	241	Q6NXR4
TFSFAILIHDVLLPE	TMEM131	461	Q92545
IRSPQVFHLLLDLLD	HEATR9	431	A2RTY3
PEHRAVLLTAVELLQ	SASH1	681	O94885
RHNTLSEDIPIVIIF	POLR3B	226	Q9NW08
VRESLIHVPLETFLQ	SH2B2	366	O14492
RSTTLEKEVPVIFIH	RALGAPB	1381	Q86X10
TFLLSLPHNIIELDV	PRKDC	731	P78527
LLDLEPRVIHSILNS	TUBG2	66	Q9NRH3
LHIPRLTEVFLVLVQ	USP34	1576	Q70CQ2
ELVLLSPHDFLHTLV	USP34	3056	Q70CQ2
LVVHYEELRRSLVPT	WSCD1	486	Q658N2
DPSLDVILLLRVLHA	TRIP12	1466	Q14669
LLRDPIYVEVSILHR	ZP4	341	Q12836
DLHLAVVPVLTALIS	TSC2	761	P49815
AIVVLSTFIHLSPDL	UNC79	2026	Q9P2D8
IAGLTFLHREPLLVT	WDR36	336	Q8NI36
SDIPIHNALRDVVLI	GUCY1A1	401	Q02108
PELLVHLTSTIERIN	PDE4DIP	1136	Q5VU43
RHLTVATLEERPFVI	GRIN2C	401	Q14957
HLTVATLEERPFVIV	GRIN2D	431	O15399
LIDHLRAPDTLTTVF	NECAB3	371	Q96P71