Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionextracellular matrix structural constituent

ABI3BP FBN1 FBN2 FN1

2.10e-05188184GO:0005201
GeneOntologyMolecularFunctionextracellular matrix constituent conferring elasticity

FBN1 FBN2

5.04e-0512182GO:0030023
GeneOntologyMolecularFunctionstructural molecule activity conferring elasticity

FBN1 FBN2

6.94e-0514182GO:0097493
GeneOntologyMolecularFunctionATP-dependent activity

DHX15 MYO3A AK9 DNAH17 IDE

1.66e-04614185GO:0140657
GeneOntologyMolecularFunctionheparin binding

ABI3BP FBN1 FN1

6.42e-04192183GO:0008201
GeneOntologyMolecularFunctionglycosaminoglycan binding

ABI3BP FBN1 FN1

1.68e-03268183GO:0005539
GeneOntologyMolecularFunctioncollagen binding

ABI3BP FN1

2.38e-0381182GO:0005518
GeneOntologyMolecularFunctionsulfur compound binding

ABI3BP FBN1 FN1

2.86e-03323183GO:1901681
GeneOntologyMolecularFunctionkinase activity

MYO3A AK9 BRD4 BUB1B

4.24e-03764184GO:0016301
GeneOntologyMolecularFunctioncysteine-type deubiquitinase activity

USP18 USP20

4.66e-03114182GO:0004843
GeneOntologyMolecularFunctioncytoskeletal motor activity

MYO3A DNAH17

4.98e-03118182GO:0003774
GeneOntologyMolecularFunctiondeubiquitinase activity

USP18 USP20

5.48e-03124182GO:0101005
GeneOntologyMolecularFunctionhormone activity

FBN1 FBN2

6.47e-03135182GO:0005179
GeneOntologyMolecularFunctionubiquitin-like protein peptidase activity

USP18 USP20

6.65e-03137182GO:0019783
GeneOntologyMolecularFunctionATP hydrolysis activity

DHX15 AK9 IDE

6.82e-03441183GO:0016887
GeneOntologyMolecularFunctionprotein serine/threonine kinase activity

MYO3A BRD4 BUB1B

7.04e-03446183GO:0004674
GeneOntologyMolecularFunctionstructural molecule activity

ABI3BP FBN1 FBN2 FN1

7.30e-03891184GO:0005198
GeneOntologyMolecularFunctiontransferase activity, transferring phosphorus-containing groups

MYO3A AK9 BRD4 BUB1B

8.73e-03938184GO:0016772
GeneOntologyMolecularFunctionintegrin binding

FBN1 FN1

1.07e-02175182GO:0005178
GeneOntologyMolecularFunctionreceptor ligand activity

FBN1 FBN2 FN1

1.23e-02547183GO:0048018
GeneOntologyMolecularFunctionsignaling receptor activator activity

FBN1 FBN2 FN1

1.27e-02554183GO:0030546
GeneOntologyMolecularFunctioncysteine-type peptidase activity

USP18 USP20

1.27e-02192182GO:0008234
GeneOntologyBiologicalProcesssequestering of TGFbeta in extracellular matrix

FBN1 FBN2

4.31e-064182GO:0035583
GeneOntologyBiologicalProcessantiviral innate immune response

DHX15 USP18 USP20

1.50e-0556183GO:0140374
GeneOntologyBiologicalProcessmaintenance of protein location in extracellular region

FBN1 FBN2

2.01e-058182GO:0071694
GeneOntologyBiologicalProcesssequestering of extracellular ligand from receptor

FBN1 FBN2

3.94e-0511182GO:0035581
GeneOntologyBiologicalProcessextracellular regulation of signal transduction

FBN1 FBN2

5.58e-0513182GO:1900115
GeneOntologyBiologicalProcessextracellular negative regulation of signal transduction

FBN1 FBN2

5.58e-0513182GO:1900116
GeneOntologyCellularComponentmicrofibril

FBN1 FBN2

5.43e-0513182GO:0001527
HumanPhenoAbnormal upper to lower segment ratio

FBN1 FBN2

8.32e-06392HP:0012772
HumanPhenoCrumpled ear

FBN1 FBN2

4.15e-05692HP:0009901
MousePhenoabnormal jaw morphology

ABI3BP BRD4 IDE FBN1 FBN2

7.68e-05530135MP:0000454
MousePhenoabnormal dermal layer morphology

BRD4 FBN1 BUB1B

1.21e-04108133MP:0001243
MousePhenoabnormal axial skeleton morphology

ABI3BP BRD4 IDE FBN1 FBN2 BUB1B CSMD1

1.29e-041458137MP:0002114
MousePhenoabnormal viscerocranium morphology

ABI3BP BRD4 IDE FBN1 FBN2

1.31e-04593135MP:0005274
MousePhenodecreased circulating interferon-beta level

USP18 USP20

1.82e-0422132MP:0008576
MousePhenoabnormal mandible morphology

BRD4 FBN1 FBN2

5.11e-04176133MP:0000458
MousePhenoabnormal cranium morphology

ABI3BP BRD4 IDE FBN1 FBN2

5.71e-04813135MP:0000438
MousePhenoabnormal craniofacial bone morphology

ABI3BP BRD4 IDE FBN1 FBN2

6.18e-04827135MP:0002116
MousePhenoabnormal circulating interferon-beta level

USP18 USP20

6.41e-0441132MP:0008550
MousePhenodecreased skeletal muscle fiber diameter

FBN2 BUB1B

6.73e-0442132MP:0009402
MousePhenoimpaired wound healing

BUB1B FN1

6.73e-0442132MP:0001792
MousePhenodecreased body fat mass

USP20 FBN1

8.07e-0446132MP:0014143
MousePhenoabnormal skeletal muscle fiber morphology

FBN1 FBN2 BUB1B

8.79e-04212133MP:0003084
DomainFBN

FBN1 FBN2

2.34e-063172IPR011398
DomainTB

FBN1 FBN2

1.63e-057172PF00683
Domain-

FBN1 FBN2

2.18e-0581723.90.290.10
DomainTB_dom

FBN1 FBN2

2.80e-059172IPR017878
DomainTB

FBN1 FBN2

2.80e-059172PS51364
DomaincEGF

FBN1 FBN2

2.50e-0426172PF12662
DomaincEGF

FBN1 FBN2

2.50e-0426172IPR026823
DomainEGF_1

FBN1 FBN2 FN1

1.48e-03255173PS00022
DomainEGF-like_CS

FBN1 FBN2 FN1

1.59e-03261173IPR013032
DomainUSP_CS

USP18 USP20

1.62e-0366172IPR018200
DomainUSP_1

USP18 USP20

1.82e-0370172PS00972
DomainUCH

USP18 USP20

1.87e-0371172PF00443
DomainUSP_2

USP18 USP20

1.87e-0371172PS00973
DomainUSP_dom

USP18 USP20

1.92e-0372172IPR028889
DomainPeptidase_C19_UCH

USP18 USP20

1.92e-0372172IPR001394
DomainUSP_3

USP18 USP20

1.92e-0372172PS50235
DomainEGF_CA

FBN1 FBN2

2.72e-0386172PF07645
DomainEGF_Ca-bd_CS

FBN1 FBN2

3.45e-0397172IPR018097
DomainEGF_CA

FBN1 FBN2

3.59e-0399172PS01187
DomainASX_HYDROXYL

FBN1 FBN2

3.66e-03100172PS00010
DomainEGF-type_Asp/Asn_hydroxyl_site

FBN1 FBN2

4.10e-03106172IPR000152
DomainEGF_CA

FBN1 FBN2

5.40e-03122172SM00179
DomainEGF-like_Ca-bd_dom

FBN1 FBN2

5.57e-03124172IPR001881
DomainAAA+_ATPase

DHX15 AK9

7.44e-03144172IPR003593
DomainAAA

DHX15 AK9

7.44e-03144172SM00382
DomainGrowth_fac_rcpt_

FBN1 FBN2

8.68e-03156172IPR009030
Domainfn3

ABI3BP FN1

9.34e-03162172PF00041
DomainFN3

ABI3BP FN1

1.20e-02185172SM00060
DomainFN3

ABI3BP FN1

1.38e-02199172PS50853
DomainFN3_dom

ABI3BP FN1

1.52e-02209172IPR003961
DomainEGF

FBN1 FBN2

1.89e-02235172SM00181
DomainEGF_3

FBN1 FBN2

1.89e-02235172PS50026
DomainEGF-like_dom

FBN1 FBN2

2.11e-02249172IPR000742
DomainEGF_2

FBN1 FBN2

2.37e-02265172PS01186
PathwayREACTOME_MOLECULES_ASSOCIATED_WITH_ELASTIC_FIBRES

FBN1 FBN2 FN1

3.80e-0632143MM14854
PathwayREACTOME_MOLECULES_ASSOCIATED_WITH_ELASTIC_FIBRES

FBN1 FBN2 FN1

5.94e-0637143M27134
PathwayREACTOME_ELASTIC_FIBRE_FORMATION

FBN1 FBN2 FN1

6.98e-0639143MM14601
PathwayREACTOME_ELASTIC_FIBRE_FORMATION

FBN1 FBN2 FN1

1.01e-0544143M26969
PathwayPID_INTEGRIN5_PATHWAY

FBN1 FN1

1.24e-0417142M212
PathwayWP_BURN_WOUND_HEALING

BRD4 FBN1 FN1

1.71e-04113143M42571
PathwayREACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX

FBN1 FBN2 FN1

1.76e-04114143MM14571
PathwayWP_HYPOTHESIZED_PATHWAYS_IN_PATHOGENESIS_OF_CARDIOVASCULAR_DISEASE

FBN1 FBN2

2.71e-0425142M39713
PathwayREACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX

FBN1 FBN2 FN1

3.22e-04140143M587
PathwayREACTOME_UB_SPECIFIC_PROCESSING_PROTEASES

USP18 USP20 IDE

7.98e-04191143MM15289
PathwayPID_INTEGRIN3_PATHWAY

FBN1 FN1

8.08e-0443142M53
PathwayREACTOME_UB_SPECIFIC_PROCESSING_PROTEASES

USP18 USP20 IDE

1.22e-03221143M27578
PathwayPID_INTEGRIN1_PATHWAY

FBN1 FN1

1.89e-0366142M18
PathwayREACTOME_EXTRACELLULAR_MATRIX_ORGANIZATION

FBN1 FBN2 FN1

1.90e-03258143MM14572
PathwayREACTOME_DEUBIQUITINATION

USP18 USP20 IDE

1.98e-03262143MM15286
PathwayREACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS

FBN1 FN1

2.50e-0376142MM14867
PathwayREACTOME_DEUBIQUITINATION

USP18 USP20 IDE

2.89e-03299143M27574
PathwayREACTOME_EXTRACELLULAR_MATRIX_ORGANIZATION

FBN1 FBN2 FN1

2.92e-03300143M610
PathwayREACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS

FBN1 FN1

3.12e-0385142M16441
Pubmed

Heparin/heparan sulfate controls fibrillin-1, -2 and -3 self-interactions in microfibril assembly.

FBN1 FBN2 FN1

4.65e-10418325034023
Pubmed

Putative functions of extracellular matrix glycoproteins in secondary palate morphogenesis.

FBN1 FBN2 FN1

6.51e-09818323055981
Pubmed

Poglut2/3 double knockout in mice results in neonatal lethality with reduced levels of fibrillin in lung tissues.

FBN1 FBN2 FN1

9.76e-09918338844137
Pubmed

Limb- and tendon-specific Adamtsl2 deletion identifies a role for ADAMTSL2 in tendon growth in a mouse model for geleophysic dysplasia.

FBN1 FBN2 FN1

1.39e-081018330738849
Pubmed

Disruption of murine Adamtsl4 results in zonular fiber detachment from the lens and in retinal pigment epithelium dedifferentiation.

FBN1 FBN2 FN1

2.55e-081218326405179
Pubmed

Proteolysis of fibrillin-2 microfibrils is essential for normal skeletal development.

FBN1 FBN2 FN1

9.45e-081818335503090
Pubmed

ADAMTS18-fibronectin interaction regulates the morphology of liver sinusoidal endothelial cells.

FBN1 FBN2 FN1

9.45e-081818339040056
Pubmed

Homo- and heterotypic fibrillin-1 and -2 interactions constitute the basis for the assembly of microfibrils.

FBN1 FBN2

2.53e-07218212399449
Pubmed

Fibrillin-1 and fibrillin-2 are essential for formation of thick oxytalan fibers in human nonpigmented ciliary epithelial cells in vitro.

FBN1 FBN2

2.53e-07218221851253
Pubmed

Fibrillins can co-assemble in fibrils, but fibrillin fibril composition displays cell-specific differences.

FBN1 FBN2

2.53e-07218212429739
Pubmed

Fibrillin assembly requires fibronectin.

FBN1 FN1

2.53e-07218219037100
Pubmed

Rare variants in FBN1 and FBN2 are associated with severe adolescent idiopathic scoliosis.

FBN1 FBN2

2.53e-07218224833718
Pubmed

Fibrillin-1 microfibril deposition is dependent on fibronectin assembly.

FBN1 FN1

2.53e-07218218653538
Pubmed

New Evidence Supporting the Role of FBN1 in the Development of Adolescent Idiopathic Scoliosis.

FBN1 FBN2

2.53e-07218230044367
Pubmed

Material and mechanical properties of bones deficient for fibrillin-1 or fibrillin-2 microfibrils.

FBN1 FBN2

2.53e-07218221440062
Pubmed

MAGP-2 has multiple binding regions on fibrillins and has covalent periodic association with fibrillin-containing microfibrils.

FBN1 FBN2

2.53e-07218215131124
Pubmed

Differences in susceptibility of inbred and outbred infant mice to enterotoxigenic Escherichia coli of bovine, porcine and human origin.

FBN2 FN1

2.53e-0721822179554
Pubmed

Nonselective assembly of fibrillin 1 and fibrillin 2 in the rodent ocular zonule and in cultured cells: implications for Marfan syndrome.

FBN1 FBN2

2.53e-07218224265020
Pubmed

Fibrillin-1 and fibrillin-2 in human embryonic and early fetal development.

FBN1 FBN2

2.53e-07218212524050
Pubmed

In vivo studies of mutant fibrillin-1 microfibrils.

FBN1 FBN2

2.53e-07218220529844
Pubmed

Immunohistochemical expression of fibrillin-1 and fibrillin-2 during tooth development.

FBN1 FBN2

2.53e-07218225524144
Pubmed

Microfibril structure masks fibrillin-2 in postnatal tissues.

FBN1 FBN2

2.53e-07218220404337
Pubmed

Fibrillin-1 mutations causing Weill-Marchesani syndrome and acromicric and geleophysic dysplasias disrupt heparan sulfate interactions.

FBN1 FBN2

2.53e-07218223133647
Pubmed

Fibrillln mutations in Marfan syndrome and related phenotypes.

FBN1 FBN2

2.53e-0721828791520
Pubmed

Three-dimensional visualization of extracellular matrix networks during murine development.

FBN2 FN1

2.53e-07218229352963
Pubmed

Structure and expression of fibrillin-2, a novel microfibrillar component preferentially located in elastic matrices.

FBN1 FBN2

2.53e-0721828120105
Pubmed

The fibrillinopathies: New insights with focus on the paradigm of opposing phenotypes for both FBN1 and FBN2.

FBN1 FBN2

2.53e-07218235419902
Pubmed

Fibrillin genes map to regions of conserved mouse/human synteny on mouse chromosomes 2 and 18.

FBN1 FBN2

2.53e-0721828307578
Pubmed

Fibrillins 1 and 2 perform partially overlapping functions during aortic development.

FBN1 FBN2

2.53e-07218216407178
Pubmed

Complex contributions of fibronectin to initiation and maturation of microfibrils.

FBN1 FN1

2.53e-07218224070235
Pubmed

Fibrillin assembly: dimer formation mediated by amino-terminal sequences.

FBN1 FBN2

2.53e-07218210504303
Pubmed

Linkage of Marfan syndrome and a phenotypically related disorder to two different fibrillin genes.

FBN1 FBN2

2.53e-0721821852206
Pubmed

N-terminal domains of fibrillin 1 and fibrillin 2 direct the formation of homodimers: a possible first step in microfibril assembly.

FBN1 FBN2

2.53e-07218210359653
Pubmed

Developmental expression of fibrillin genes suggests heterogeneity of extracellular microfibrils.

FBN1 FBN2

2.53e-0721827744963
Pubmed

Selective integrin subunit reduction disrupts fibronectin extracellular matrix deposition and fibrillin 1 gene expression.

FBN1 FN1

2.53e-07218222782528
Pubmed

Fibrillin microfibrils in bone physiology.

FBN1 FBN2

2.53e-07218226408953
Pubmed

Arg-Gly-Asp-containing domains of fibrillins-1 and -2 distinctly regulate lung fibroblast migration.

FBN1 FBN2

2.53e-07218218006876
Pubmed

Adamts18 modulates the development of the aortic arch and common carotid artery.

FBN1 FBN2 FN1

3.00e-072618334189436
Pubmed

Adamtsl2 deletion results in bronchial fibrillin microfibril accumulation and bronchial epithelial dysplasia--a novel mouse model providing insights into geleophysic dysplasia.

FBN1 FBN2 FN1

5.18e-073118325762570
Pubmed

Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics.

ABI3BP FBN1 FBN2 FN1

6.37e-0713518428675934
Pubmed

Interaction of tropoelastin with the amino-terminal domains of fibrillin-1 and fibrillin-2 suggests a role for the fibrillins in elastic fiber assembly.

FBN1 FBN2

7.59e-07318210825173
Pubmed

Adamts10 inactivation in mice leads to persistence of ocular microfibrils subsequent to reduced fibrillin-2 cleavage.

FBN1 FBN2

7.59e-07318230201140
Pubmed

Molecular structure and interaction of recombinant human type XVI collagen.

FBN1 FN1

7.59e-07318215165854
Pubmed

Fibrillin-1 and -2 differentially modulate endogenous TGF-β and BMP bioavailability during bone formation.

FBN1 FBN2

7.59e-07318220855508
Pubmed

Adamts18 Deficiency Causes Spontaneous SMG Fibrogenesis in Adult Mice.

FBN1 FBN2 FN1

8.94e-073718334323105
Pubmed

Fibrillin-2 is a key mediator of smooth muscle extracellular matrix homeostasis during mouse tracheal tubulogenesis.

FBN1 FBN2 FN1

1.14e-064018330578393
Pubmed

Latent transforming growth factor beta-binding protein 1 interacts with fibrillin and is a microfibril-associated protein.

FBN1 FBN2

1.52e-06418212429738
Pubmed

Human eye development is characterized by coordinated expression of fibrillin isoforms.

FBN1 FBN2

1.52e-06418225406291
Pubmed

Immunolocalization of microfibril and microfibril-associated proteins in the subendothelial matrix of the developing mouse aorta.

FBN1 FN1

1.52e-0641828006086
Pubmed

Extracellular microfibrils control osteoblast-supported osteoclastogenesis by restricting TGF{beta} stimulation of RANKL production.

FBN1 FBN2

1.52e-06418220729550
Pubmed

Comprehensive genetic analysis of relevant four genes in 49 patients with Marfan syndrome or Marfan-related phenotypes.

FBN1 FBN2

1.52e-06418216835936
Pubmed

Comparative proteomic analysis of supportive and unsupportive extracellular matrix substrates for human embryonic stem cell maintenance.

FBN1 FBN2 FN1

2.25e-065018323658023
Pubmed

Characterization of Microfibrillar-associated Protein 4 (MFAP4) as a Tropoelastin- and Fibrillin-binding Protein Involved in Elastic Fiber Formation.

FBN1 FBN2

2.53e-06518226601954
Pubmed

Fibrillin-1 interactions with fibulins depend on the first hybrid domain and provide an adaptor function to tropoelastin.

FBN1 FBN2

2.53e-06518217255108
Pubmed

POGLUT2 and POGLUT3 O-glucosylate multiple EGF repeats in fibrillin-1, -2, and LTBP1 and promote secretion of fibrillin-1.

FBN1 FBN2

2.53e-06518234411563
Pubmed

Relaxin regulates fibrillin 2, but not fibrillin 1, mRNA and protein expression by human dermal fibroblasts and murine fetal skin.

FBN1 FBN2

2.53e-06518212590922
Pubmed

Development, composition, and structural arrangements of the ciliary zonule of the mouse.

FBN1 FBN2

2.53e-06518223493297
Pubmed

Myh10 deficiency leads to defective extracellular matrix remodeling and pulmonary disease.

FBN1 FBN2 FN1

2.53e-065218330389913
Pubmed

Of mice and Marfan: genetic linkage analyses of the fibrillin genes, Fbn1 and Fbn2, in the mouse genome.

FBN1 FBN2

3.79e-0661827873879
Pubmed

Regulation of limb patterning by extracellular microfibrils.

FBN1 FBN2

5.30e-06718211470817
Pubmed

Aortic aneurysm generation in mice with targeted deletion of integrin-linked kinase in vascular smooth muscle cells.

FBN1 FN1

5.30e-06718221778429
Pubmed

Mapping Extracellular Protein-Protein Interactions Using Extracellular Proximity Labeling (ePL).

ABI3BP FBN1 FBN2 FN1

7.03e-0624718439238192
Pubmed

Adamts17 is involved in skeletogenesis through modulation of BMP-Smad1/5/8 pathway.

FBN1 FBN2

7.07e-06818231201465
Pubmed

Targeting of bone morphogenetic protein growth factor complexes to fibrillin.

FBN1 FBN2

7.07e-06818218339631
Pubmed

Microfibril-associated glycoprotein-2 interacts with fibrillin-1 and fibrillin-2 suggesting a role for MAGP-2 in elastic fiber assembly.

FBN1 FBN2

9.09e-06918212122015
Pubmed

MBTPS1/SKI-1/S1P proprotein convertase is required for ECM signaling and axial elongation during somitogenesis and vertebral development†.

FBN2 FN1

9.09e-06918225652402
Pubmed

Mice lacking the extracellular matrix adaptor protein matrilin-2 develop without obvious abnormalities.

FBN2 FN1

9.09e-06918215296947
Pubmed

Distribution of fibronectin, type I collagen, type IV collagen, and laminin in the cardiac jelly of the mouse embryonic heart with retinoic acid-induced complete transposition of the great arteries.

FBN1 FN1

1.14e-05101829415455
Pubmed

Comprehensive proteomic characterization of stem cell-derived extracellular matrices.

FBN1 FBN2 FN1

1.16e-058618328327460
Pubmed

A SARS-CoV-2 protein interaction map reveals targets for drug repurposing.

BRD4 IDE FBN1 FBN2

1.47e-0529818432353859
Pubmed

USP18 recruits USP20 to promote innate antiviral response through deubiquitinating STING/MITA.

USP18 USP20

1.66e-051218227801882
Pubmed

Matrilin-2 interacts with itself and with other extracellular matrix proteins.

FBN2 FN1

1.66e-051218212180907
Pubmed

A distinct transcriptome characterizes neural crest-derived cells at the migratory wavefront during enteric nervous system development.

FBN1 FBN2

1.66e-051218236779913
Pubmed

Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin Activity in Human Atrial Fibrillation.

ABI3BP FBN1 FN1

1.66e-059718327559042
Pubmed

Proteomics characterization of extracellular space components in the human aorta.

ABI3BP FBN1 FN1

1.88e-0510118320551380
Pubmed

Impaired ADAMTS9 secretion: A potential mechanism for eye defects in Peters Plus Syndrome.

FBN2 FN1

2.29e-051418227687499
Pubmed

α5 and αv integrins cooperate to regulate vascular smooth muscle and neural crest functions in vivo.

FBN1 FN1

2.65e-051518225670798
Pubmed

Role for ephrinB2 in postnatal lung alveolar development and elastic matrix integrity.

FBN1 FN1

3.85e-051818218651661
Pubmed

Fibronectin isoforms promote postnatal skeletal development.

FBN1 FN1

3.85e-051818239159790
Pubmed

Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins.

ABI3BP FBN1 FN1

5.65e-0514618327068509
Pubmed

Mohawk promotes the maintenance and regeneration of the outer annulus fibrosus of intervertebral discs.

FBN1 FN1

5.81e-052218227527664
Pubmed

Transforming growth factor-β signaling in myogenic cells regulates vascular morphogenesis, differentiation, and matrix synthesis.

FBN1 FN1

5.81e-052218221979435
Pubmed

ADAMTS9-Mediated Extracellular Matrix Dynamics Regulates Umbilical Cord Vascular Smooth Muscle Differentiation and Rotation.

FBN2 FN1

6.36e-052318226027930
Pubmed

The matrisome: in silico definition and in vivo characterization by proteomics of normal and tumor extracellular matrices.

ABI3BP FBN1 FN1

8.41e-0516718322159717
Pubmed

Endothelial Loss of ETS1 Impairs Coronary Vascular Development and Leads to Ventricular Non-Compaction.

FBN1 FN1

8.81e-052718235894043
Pubmed

Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression.

FBN1 FBN2 FN1

9.67e-0517518328071719
Pubmed

ADAMTS18 Deficiency Leads to Pulmonary Hypoplasia and Bronchial Microfibril Accumulation.

FBN1 FBN2

1.09e-043018232882513
Pubmed

Heritable Thoracic Aortic Disease Overview

FBN1 FBN2

1.09e-043018220301299
Pubmed

Targeting TRIM37-driven centrosome dysfunction in 17q23-amplified breast cancer.

FBN1 FBN2 BUB1B

1.12e-0418418332908313
Pubmed

Ubiquitin-specific peptidase 2a (USP2a) deubiquitinates and stabilizes β-catenin.

USP18 USP20

1.32e-043318230323974
Pubmed

Three-dimensional visualization of testis cord morphogenesis, a novel tubulogenic mechanism in development.

IDE FBN1 FBN2

1.35e-0419618319334288
Pubmed

A microarray of ubiquitylated proteins for profiling deubiquitylase activity reveals the critical roles of both chain and substrate.

USP18 USP20

1.58e-043618222626734
Pubmed

O-fucosylation of thrombospondin type 1 repeats is essential for ECM remodeling and signaling during bone development.

FBN1 FBN2

1.58e-043618235167946
Pubmed

Biochemical Reduction of the Topology of the Diverse WDR76 Protein Interactome.

FBN1 FBN2 FN1

1.87e-0421918331353912
Pubmed

Intrinsic BET inhibitor resistance in SPOP-mutated prostate cancer is mediated by BET protein stabilization and AKT-mTORC1 activation.

DHX15 BRD4

1.95e-044018228805822
Pubmed

Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling.

ABI3BP DNAH17 CSMD1

3.28e-0426518319240061
Pubmed

Mouse screen reveals multiple new genes underlying mouse and human hearing loss.

USP20 LNX2 DNAH17 IDE CSMD1

3.35e-04124218530973865
Pubmed

Targeted Disruption of Mouse Dip2B Leads to Abnormal Lung Development and Prenatal Lethality.

FBN2 FN1

3.43e-045318233153107
Pubmed

Homologous Transcription Factors DUX4 and DUX4c Associate with Cytoplasmic Proteins during Muscle Differentiation.

IDE FBN1 FN1

3.50e-0427118326816005
InteractionMFAP5 interactions

FBN1 FBN2 ZNF507

1.29e-0552183int:MFAP5
InteractionHRG interactions

FBN1 FBN2 FN1

2.30e-0563183int:HRG
InteractionPAPSS1 interactions

DHX15 BRD4 IDE

4.53e-0579183int:PAPSS1
InteractionMFAP2 interactions

FBN1 FBN2

4.95e-0512182int:MFAP2
InteractionTAB1 interactions

USP18 BRD4 LNX2 FN1

6.36e-05252184int:TAB1
InteractionMYL6 interactions

USP18 BRD4 USP20 FN1

6.66e-05255184int:MYL6
InteractionLTBP1 interactions

FBN1 FBN2 FN1

7.15e-0592183int:LTBP1
InteractionTIMP2 interactions

ABI3BP FBN1 FBN2 FN1

9.18e-05277184int:TIMP2
InteractionAKR1C1 interactions

BRD4 FN1

1.42e-0420182int:AKR1C1
InteractionSMNDC1 interactions

DHX15 BRD4 IDE

1.42e-04116183int:SMNDC1
InteractionPPIH interactions

BRD4 LNX2 FN1

1.42e-04116183int:PPIH
InteractionHDAC3 interactions

USP18 AK9 BRD4 BUB1B

1.47e-04313184int:HDAC3
InteractionNTN5 interactions

FBN1 FBN2

2.06e-0424182int:NTN5
InteractionPUS7 interactions

DHX15 BRD4 IDE

2.23e-04135183int:PUS7
InteractionZNF408 interactions

USP20 FBN1 FBN2

2.75e-04145183int:ZNF408
InteractionDDOST interactions

BRD4 LNX2 BUB1B FN1

2.94e-04375184int:DDOST
InteractionH4C4 interactions

BRD4 FN1

3.02e-0429182int:H4C4
InteractionELN interactions

FBN1 FBN2

3.02e-0429182int:ELN
GeneFamilyUbiquitin specific peptidases

USP18 USP20

5.09e-0456112366
GeneFamilyFibronectin type III domain containing

ABI3BP FN1

4.06e-03160112555
CoexpressionTSUNODA_CISPLATIN_RESISTANCE_DN

FBN1 FBN2 FN1

5.22e-0650183M5014
CoexpressionNABA_ECM_GLYCOPROTEINS

ABI3BP FBN1 FBN2 FN1

7.72e-06191184MM17059
CoexpressionNABA_ECM_GLYCOPROTEINS

ABI3BP FBN1 FBN2 FN1

8.55e-06196184M3008
CoexpressionHALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION

ABI3BP FBN1 FBN2 FN1

9.26e-06200184M5930
CoexpressionNABA_CORE_MATRISOME

ABI3BP FBN1 FBN2 FN1

3.01e-05270184MM17057
CoexpressionNABA_CORE_MATRISOME

ABI3BP FBN1 FBN2 FN1

3.23e-05275184M5884
CoexpressionDI_MARTINO_MATRISOME_HIGHLY_PROLIFERATIVE_HNSCC_TUMOR_CELL_DERIVED

FBN2 FN1

6.02e-0517182M47995
CoexpressionMEBARKI_HCC_PROGENITOR_WNT_UP_CTNNB1_INDEPENDENT

FBN1 FN1

1.22e-0424182M38986
CoexpressionDI_MARTINO_MATRISOME_HIGHLY_PROLIFERATIVE_HNSCC

FBN2 FN1

1.55e-0427182M47994
CoexpressionPETRETTO_CARDIAC_HYPERTROPHY

FBN1 FN1

2.47e-0434182M14043
CoexpressionDODD_NASOPHARYNGEAL_CARCINOMA_UP

DHX15 USP18 BRD4 FBN1 BUB1B FN1

2.51e-041407186M14427
CoexpressionGSE15659_RESTING_VS_ACTIVATED_TREG_UP

AK9 DNAH17 C9orf40

2.91e-04192183M3561
CoexpressionGSE21546_UNSTIM_VS_ANTI_CD3_STIM_SAP1A_KO_DP_THYMOCYTES_UP

ABI3BP AK9 FN1

3.19e-04198183M7550
CoexpressionGSE37301_MULTIPOTENT_PROGENITOR_VS_COMMON_LYMPHOID_PROGENITOR_DN

USP18 FBN1 C9orf40

3.28e-04200183M8842
CoexpressionGSE10239_MEMORY_VS_KLRG1HIGH_EFF_CD8_TCELL_DN

IDE BUB1B ZNF507

3.28e-04200183M3067
CoexpressionGSE10239_MEMORY_VS_KLRG1INT_EFF_CD8_TCELL_DN

BUB1B ZNF507 C9orf40

3.28e-04200183M3059
CoexpressionRICKMAN_HEAD_AND_NECK_CANCER_D

ABI3BP TCN1

3.42e-0440182M19164
CoexpressionPICCALUGA_ANGIOIMMUNOBLASTIC_LYMPHOMA_UP

ABI3BP FBN1 FN1

3.84e-04211183M12225
CoexpressionRODWELL_AGING_KIDNEY_NO_BLOOD_UP

ABI3BP FBN1 FN1

4.57e-04224183M9893
CoexpressionTURASHVILI_BREAST_DUCTAL_CARCINOMA_VS_DUCTAL_NORMAL_UP

FBN1 FN1

4.73e-0447182M7585
CoexpressionCHICAS_RB1_TARGETS_CONFLUENT

ABI3BP FBN1 FBN2 FN1

5.21e-04567184M2129
ToppCellPCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_Arw_fibro_(16)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

ABI3BP FBN1 FBN2 CSMD1

8.09e-071851847dcdc009c5681ee05dd18968f7e85c3403fe34af
ToppCelldroplet-Kidney-KIDNEY-1m-Mesenchymal-fibroblast|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ABI3BP FBN1 FBN2 CSMD1

8.27e-0718618494d577dbb6bfacf50632e1fe8af041b35a1e6b23
ToppCelldroplet-Fat-Scat-21m-Mesenchymal-mesenchymal_stem_cell_of_adipose|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ABI3BP FBN1 FBN2 FN1

8.63e-07188184e54e09d34e263d5709c337914809e61e74e20591
ToppCelldroplet-Fat-Scat-21m-Mesenchymal|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ABI3BP FBN1 FBN2 FN1

8.63e-071881847fc9810ab14354cb512e2b1285562009c10203f5
ToppCelldroplet-Pancreas-PANCREAS-30m-Mesenchymal-pancreatic_stellate_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ABI3BP TCN1 FBN1 FBN2

8.82e-071891841821ae4a6e37ee4c6308071883f3f447a7c53c53
ToppCellFibroblast-C|World / shred on cell class and cell subclass (v4)

ABI3BP FBN1 FBN2 FN1

8.82e-0718918458e0400fbab5a0755504275aef5cf7986149abab
ToppCelldroplet-Pancreas-PANCREAS-30m-Mesenchymal-pancreatic_stellate_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ABI3BP TCN1 FBN1 FBN2

8.82e-071891841e4d7e8dc98b3d70351e6a6c2aaf9ca01f141b8f
ToppCelldroplet-Pancreas-PANCREAS-30m-Mesenchymal|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ABI3BP TCN1 FBN1 FBN2

8.82e-071891841dc415ed41815f4296dafd8cf7f3e014c44db1db
ToppCelldroplet-Kidney-nan-18m-Mesenchymal|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ABI3BP FBN1 CSMD1 FN1

9.39e-0719218438d7a24ae205ef91ed2e0f402d8022f2a9cdb243
ToppCelldroplet-Kidney-KIDNEY-30m-Mesenchymal-fibroblast|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ABI3BP FBN1 CSMD1 FN1

9.39e-07192184853a930e0641ffb50cbb4cef5837c70d75c3fc39
ToppCelldroplet-Kidney-nan-18m-Mesenchymal-fibroblast|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ABI3BP FBN1 CSMD1 FN1

9.39e-0719218484149a5c6c3b3c9b86aed77cf8e72d99ef099fab
ToppCell5'-GW_trimst-2-LargeIntestine-Mesenchymal-immature_mesenchymal_cell-Mesoderm_2_(ZEB2+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ABI3BP FBN1 FBN2 FN1

9.39e-07192184f053b89bfd6048c227667ff01c38df7c51d8a496
ToppCelldroplet-Kidney-nan-18m-Mesenchymal-Stroma____fibroblast|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ABI3BP FBN1 CSMD1 FN1

9.39e-0719218404d155897ed075c359933080e36a4ab2150b6e9f
ToppCelldroplet-Kidney-KIDNEY-30m-Mesenchymal|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ABI3BP FBN1 CSMD1 FN1

9.39e-0719218449281626ecad0456fdbded2378b7028d7b589686
ToppCelldroplet-Pancreas-Exocrine-21m-Mesenchymal|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ABI3BP FBN1 FBN2 FN1

9.78e-0719418404ecb609d233a4b12e275c604810937830363e17
ToppCelldroplet-Pancreas-Exocrine-21m-Mesenchymal-pancreatic_stellate_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ABI3BP FBN1 FBN2 FN1

9.78e-07194184775600880bb77781de48085d8744c1030223de1f
ToppCell5'-GW_trimst-2-LargeIntestine-Mesenchymal-immature_mesenchymal_cell|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ABI3BP FBN1 FBN2 FN1

1.02e-06196184cbfe01ba8071864e19b37028236ae35789f630fe
ToppCell5'-GW_trimst-2-SmallIntestine-Mesenchymal|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ABI3BP FBN1 FBN2 FN1

1.10e-06200184a603e8a999612d523bbce9d0feca9296d4a24c97
ToppCellAdult-Mesenchymal-chondrocyte|Adult / Lineage, Cell type, age group and donor

ABI3BP FBN1 FN1

3.40e-051591833f7305ee76447064b5c846c4f576360a2f7e0b7c
ToppCellfacs-Limb_Muscle-forelimb_and_hindlimb-18m-Mesenchymal-mesenchymal_stem_cell|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ABI3BP FBN1 FN1

3.80e-05165183f80665b75d43f1bf6919d59fc762e7e0bac653f2
ToppCellfacs-Mammary_Gland-Mammary_Gland-21m-Mesenchymal-stromal_cell|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ABI3BP FBN1 FN1

4.08e-051691838bfa2d3bb541d02f55d7c95b8fd156c8403befca
ToppCellfacs-Mammary_Gland-Mammary_Gland-21m-Mesenchymal|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ABI3BP FBN1 FN1

4.08e-05169183bb43abad2c049b7f4d307737347290e01b3339a3
ToppCell5'-Adult-LargeIntestine-Mesenchymal-fibroblastic-Stromal_1_(ADAMDEC1+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FBN1 FBN2 FN1

4.08e-05169183c0824a93674e2bff0f09b2d2fab5bab016a2e379
ToppCellfacs-Mammary_Gland-Mammary_Gland-21m-Mesenchymal-stromal_cell|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ABI3BP FBN1 FN1

4.08e-051691835f18e3f40a5b1b167903f37516ec8181e889c7c5
ToppCell5'-Parenchyma_lung-Immune_Myeloid-Myeloid_monocytic-classical_monocyte-Classical_monocytes-Classical_monocytes_L.1.2.4.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

TCN1 USP20 FBN2

4.15e-05170183cf22a843ae2d9cd6693507fed2b7c6a45abea10e
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Cycling_Myofibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

FBN1 BUB1B FN1

4.22e-05171183b92963f9f247d2e5e2e6c51c6dbf70e527cd2f55
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Cycling_Myofibroblast-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

FBN1 BUB1B FN1

4.22e-05171183b0373ed8283ee1792b6a490bff93906546978593
ToppCell343B-Fibroblasts-Fibroblast-A_(Fibroblast_progenitors)-|343B / Donor, Lineage, Cell class and subclass (all cells)

ABI3BP FBN1 FN1

4.60e-051761832e94bbe17c0bb65dc58b4ebc0cb829258bd7373b
ToppCell343B-Fibroblasts-Fibroblast-A_(Fibroblast_progenitors)|343B / Donor, Lineage, Cell class and subclass (all cells)

ABI3BP FBN1 FN1

4.60e-05176183f33ab41d121b59d871ad7d48ca021524a027d2ef
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_ascending_limb_epithelial_cell-Ascending_Thin_Limb_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ABI3BP DNAH17 FBN2

4.84e-0517918355bc69f107fc710db7617c428575792adfdbbcc1
ToppCellfacs-Kidney-nan-24m-Mesenchymal|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ABI3BP FBN1 FN1

4.92e-05180183f9f8245cbcdea18c15e2976c85b72c6807309787
ToppCellRA-01._Fibroblast_I|World / Chamber and Cluster_Paper

ABI3BP FBN1 FN1

5.00e-051811832b6ddeb53a79a658e2ba78527ff48c155b20daa6
ToppCellmetastatic_Brain-Fibroblasts-Myofibroblasts|metastatic_Brain / Location, Cell class and cell subclass

FBN1 FBN2 FN1

5.00e-05181183bd0b5f74f9c81ec0f1592710774a4fdf33d9d5a9
ToppCellChildren_(3_yrs)-Mesenchymal-matrix_fibroblast_1_cell-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

ABI3BP FBN1 FN1

5.00e-051811839ede19228ba5c0668a9c06c915510b95585216ef
ToppCellCOVID-19-Heart-Fib_+_EC_+_Pericyte|COVID-19 / Disease (COVID-19 only), tissue and cell type

ABI3BP FBN1 FN1

5.08e-05182183fbd5e332df73bf7141c822fa67b76367dc962017
ToppCellfacs-Mammary_Gland-Mammary_Gland-18m-Mesenchymal|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ABI3BP FBN1 FN1

5.16e-051831835cfcd589a480e67654d3d94e71916f122150db10
ToppCellfacs-Mammary_Gland-Mammary_Gland-18m-Mesenchymal-stromal_cell|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ABI3BP FBN1 FN1

5.16e-05183183c3ea8d3b916ffcaca3156e0d77a952724554c4ab
ToppCellfacs-Mammary_Gland-Mammary_Gland-18m-Mesenchymal-stromal_cell|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ABI3BP FBN1 FN1

5.16e-0518318381003ddc24164959dd41bb12fcac72638789b8f2
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_ascending_limb_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ABI3BP DNAH17 FBN2

5.16e-0518318383592c332b1e82673f993d37c7f480befdc3dcda
ToppCellfacs-Mammary_Gland-Mammary_Gland-3m-Mesenchymal-stromal_cell|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ABI3BP FBN1 FN1

5.33e-051851833cd0686a14e734a0f243070ab939adcb4c454478
ToppCellfacs-Mammary_Gland-Mammary_Gland-3m-Mesenchymal-stromal_cell|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ABI3BP FBN1 FN1

5.33e-0518518300258f458cbf6d36449db95528a6b5038d731d2d
ToppCellfacs-Mammary_Gland-Mammary_Gland-3m-Mesenchymal|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ABI3BP FBN1 FN1

5.33e-05185183a94694e226856bc5b168464f52d76004145717a5
ToppCelldroplet-Fat-Scat-21m-Mesenchymal-Cd34+|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ABI3BP FBN1 FBN2

5.33e-0518518301bbe1e09f9ccae837a03ea2cdd168fa10800942
ToppCellCOVID-19-Heart-Fib_2|COVID-19 / Disease (COVID-19 only), tissue and cell type

ABI3BP FBN1 FN1

5.33e-051851838f95d8e591bf7379d13f5a0545b0cb49e2b1ab5d
ToppCellPCW_07-8.5-Mesenchymal-Mesenchymal_fibroblastic-mes_immature_COL13A1^pos_fibro2_(5)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

ABI3BP FBN1 FN1

5.33e-051851831ac6a32cc56d5d819649bdd99518e2ead0eead4c
ToppCellE17.5-Mesenchymal-mesenchymal_fibroblast-mesenchymal_alveolar_niche_cell|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

ABI3BP FBN1 FN1

5.33e-05185183c85bba1210f1d389add3e40be9b96abac40cf8c1
ToppCelldroplet-Kidney-KIDNEY-1m-Mesenchymal-Stroma____fibroblast|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ABI3BP FBN1 FBN2

5.33e-05185183785c55d39909fac74415f24427979691e7e694e6
ToppCelldroplet-Kidney-KIDNEY-1m-Mesenchymal|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ABI3BP FBN1 FBN2

5.33e-0518518397a1dcacbc48dc3f41c26fbb59af35c935f894d4
ToppCellfacs-Limb_Muscle-Muscle_forelimb_and_hindlimb-18m-Mesenchymal-mesenchymal_stem_cell|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ABI3BP FBN1 FN1

5.42e-05186183a7ab70b049742dfe7ee30557031bfac6412edf52
ToppCellfacs-Limb_Muscle-ForelimbandHindlimb-24m-Mesenchymal-mesenchymal_stem_cell|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ABI3BP FBN1 FN1

5.42e-05186183ff6ccfdf2509f96caa10281c29a95b432f6c6dcc
ToppCell5'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2-Alveolar_fibroblasts-Alveolar_fibroblasts_L.2.1.1.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ABI3BP FBN1 FN1

5.42e-051861835473283fb95cee556b1f6934cf72169b676b5bcc
ToppCellPCW_07-8.5-Mesenchymal-Mesenchymal_fibroblastic-mes_Arw_fibro_(16)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

ABI3BP FBN1 FBN2

5.42e-051861834d68ee3d32f7ef884faf402ef92b31b0eb4656f1
ToppCellPCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_Arw_fibro_(16)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

ABI3BP FBN1 FBN2

5.51e-051871835258674d0346e5c51a4b965efcdc1790c970845d
ToppCelldroplet-Pancreas-Exocrine-18m-Mesenchymal-pancreatic_stellate_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ABI3BP FBN1 FBN2

5.51e-051871834e553721fa5598cb211f44e3226280b7e6885484
ToppCellfacs-Trachea-nan-24m-Mesenchymal|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ABI3BP FBN1 FN1

5.51e-0518718371385068e3fd0bfa7822ae176113a49460c8636b
ToppCelldroplet-Pancreas-Exocrine-18m-Mesenchymal|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ABI3BP FBN1 FBN2

5.51e-05187183d36e7fc6125e7a4310499365022d38f34b757a73
ToppCelldroplet-Pancreas-Exocrine-18m-Mesenchymal-pancreatic_stellate_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ABI3BP FBN1 FBN2

5.51e-05187183827eae63fabf6892a82ce7779b5f395958d3d628
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Cycling_Myofibroblast-|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

FBN1 BUB1B FN1

5.51e-05187183e41e39fd3791acf8ae5376cc5061e196d96868ae
ToppCellLA-01._Fibroblast_I|World / Chamber and Cluster_Paper

ABI3BP FBN1 FN1

5.51e-051871834ea486991f66c29728d127171a07b81404ec0b78
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Cycling_Myofibroblast|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

FBN1 BUB1B FN1

5.51e-05187183cefa211ef224e803ea9467882e2ca74d0b1492f1
ToppCellfacs-Trachea-nan-24m-Mesenchymal-nan|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ABI3BP FBN1 FN1

5.51e-05187183e891e571f6bb9433a0046215de6cabd89ed1effc
ToppCellControl-Fibroblasts-Other_FB|Control / group, cell type (main and fine annotations)

ABI3BP FBN1 FN1

5.51e-05187183bd3739c4a52aa1ba5deffd778e113a9800f7e158
ToppCellControl-Fibroblasts-Alveolar_FB|Control / group, cell type (main and fine annotations)

ABI3BP FBN1 FN1

5.51e-0518718392d468dde81125d51daf7abd4703741abe1ab91c
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Endothelial-lymphatic_endothelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ABI3BP FBN1 FN1

5.59e-0518818326915db8863f4115b46a81982e187322e21600fd
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ABI3BP FBN1 FN1

5.59e-051881833f76c0f912f8f023ea425be7f43593b3d7f967e3
ToppCellMesenchymal-chondrocyte|World / Lineage, Cell type, age group and donor

FBN1 FBN2 FN1

5.59e-051881837b1e3f8a941eaa68e89c562129a92314642eec66
ToppCell10x3'2.3-week_14-16-Mesenchymal_fibro-stroma-endosteal_fibroblast|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

ABI3BP FBN1 CSMD1

5.59e-051881830e2d1b21f0a7ee306e7dae16fc8c19d16a467883
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex-lymphatic_endothelial_cell_of_renal_cortex|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ABI3BP FBN1 FN1

5.59e-0518818361ee7b152745164293d8a44ef91ee2393efbdca5
ToppCellE16.5-samps-Mesenchymal|E16.5-samps / Age Group, Lineage, Cell class and subclass

ABI3BP FBN1 FN1

5.59e-051881833f0f662be684e3a4c6652e636cc135a39a1d2790
ToppCelldroplet-Limb_Muscle-nan-21m-Mesenchymal-mesenchymal_stem_cell|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ABI3BP FBN1 FN1

5.68e-0518918356f43e00d81cf3cdf0c39f8d7120f5beab72e258
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Afferent_/_Efferent_Arteriole_Endothelial_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ABI3BP FBN1 FN1

5.68e-0518918312b6f1c3bf526b90e112374bf937701f645c5780
ToppCell10x3'2.3-week_12-13-Mesenchymal_fibro-stroma-endosteal_fibroblast|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

ABI3BP FBN1 FN1

5.68e-05189183c392491aabe8a3e90974ab2ea123bbbe5200439d
ToppCellLPS_only-Endothelial-Endothelial-Artery|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

FBN1 CSMD1 FN1

5.68e-05189183b028466fcd36fdeceec752e55a24286a1cd62ae4
ToppCellfacs-Diaphragm-Limb_Muscle-18m-Mesenchymal-mesenchymal_stem_cell|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ABI3BP FBN1 FN1

5.68e-05189183dde037322c8caec0c04c5be1c1b59a167824ad9f
ToppCellfacs-Thymus-Epithelium-3m-Mesenchymal|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ABI3BP FBN1 FN1

5.68e-051891831db5dd1ef2a65251af2d5696622d1dd9c4ae2b55
ToppCellfacs-Thymus-Epithelium-3m-Mesenchymal-fibroblast|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ABI3BP FBN1 FN1

5.68e-05189183bfb1c183a8a2752a2368b74150e66181c6a9da48
ToppCellfacs-Thymus-Epithelium-3m-Mesenchymal-fibroblast|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ABI3BP FBN1 FN1

5.68e-0518918314833feea8f80744a06ece73f813eaeff8c4dd61
ToppCellE18.5-samps-Mesenchymal|E18.5-samps / Age Group, Lineage, Cell class and subclass

ABI3BP FBN1 FN1

5.68e-051891830c18d3de4720759cf802eefb4d0ddde2a9246a1a
ToppCellLPS-IL1RA+antiTNF-Endothelial-Endothelial-Artery|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

FBN1 CSMD1 FN1

5.68e-05189183c45734970036e6d28d5e3fe7c9458fae38a3f624
ToppCelldroplet-Mammary_Gland-nan-21m-Mesenchymal-stromal_cell|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ABI3BP FBN1 FN1

5.68e-05189183bc54ffd7bd1627a36747a80ce5139e4a69928400
ToppCellPND07-28-samps-Mesenchymal-Matrix_fibroblast|PND07-28-samps / Age Group, Lineage, Cell class and subclass

ABI3BP FBN1 FN1

5.68e-05189183dc5164591dea45b420798b94dda211be03daa70c
ToppCelldroplet-Limb_Muscle|droplet / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ABI3BP FBN1 FN1

5.77e-0519018306c2b13fa88abbcb8086f13b8d98a156e41e4198
ToppCelldroplet-Mammary_Gland-nan-3m-Mesenchymal|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ABI3BP FBN1 FN1

5.77e-05190183bd0d68dc1b6f388190a6ba8a83b011619abe2bdd
ToppCelldroplet-Mammary_Gland-nan-21m-Mesenchymal-stromal_cell|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ABI3BP FBN1 FN1

5.77e-05190183f3ca94a31a35eed5fecf3c4b8c957e1bc4150158
ToppCelldroplet-Mammary_Gland-nan-3m-Mesenchymal-stromal_cell|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ABI3BP FBN1 FN1

5.77e-05190183e275de94468872e70cf305b3b450823d4c9c5e3f
ToppCellPND07-28-samps-Mesenchymal-Matrix_fibroblast-FB-3|PND07-28-samps / Age Group, Lineage, Cell class and subclass

ABI3BP FBN1 FN1

5.77e-051901831196b8ea2c44c7c80f5ee589dd517e6a413f2077
ToppCellfacs-Diaphragm-Limb_Muscle-24m-Mesenchymal-mesenchymal_stem_cell|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ABI3BP FBN1 FN1

5.77e-05190183d13fd234caa3fc69d8a59bc0060cdacdf716ee55
ToppCellControl-Fibroblasts|Control / group, cell type (main and fine annotations)

ABI3BP FBN1 FN1

5.77e-051901833a42a9b98d954685d38a741f44545898d0e3e9ce
ToppCellLPS-IL1RA-Endothelial-Endothelial-Artery|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

FBN1 CSMD1 FN1

5.77e-05190183aed65d584ca0c25f6a8313c66b421a6618af82ea
ToppCelldroplet-Mammary_Gland-nan-3m-Mesenchymal-stromal_cell|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ABI3BP FBN1 FN1

5.77e-05190183ee2f4a55d2fd18b83e55399b5b5697a15a2d2e70
ToppCelldroplet-Mammary_Gland-nan-21m-Mesenchymal|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ABI3BP FBN1 FN1

5.77e-05190183c2cd1eb674162ee40502c3380b7245c85079c7ce
ToppCellCOVID-19-kidney-AQP1+SLC14A1+EC|kidney / Disease (COVID-19 only), tissue and cell type

ABI3BP FBN1 FN1

5.77e-051901831519f34d31fe0817184c5865a0bc9f0cb479b1a4
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_ascending_limb_epithelial_cell-Ascending_Thin_Limb_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ABI3BP DNAH17 FBN2

5.77e-0519018359bbbd2c8d4b7ce46c54ca8022b1557e7e5eee2a
ToppCelldroplet-Mammary_Gland-nan-18m-Mesenchymal-stromal_cell|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ABI3BP FBN1 FN1

5.77e-0519018347077579496c5340e99f61499427a3a36b566da3
ToppCelldroplet-Mammary_Gland-nan-21m|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ABI3BP FBN1 FN1

5.86e-051911838022059e434fd411dc539819f969bd4f94861281
ToppCelldroplet-Mammary_Gland-nan-18m-Mesenchymal|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ABI3BP FBN1 FN1

5.86e-0519118319c67a812b8ce97472d316acd15aeefe8736000d
ToppCelldroplet-Lung-3m-Mesenchymal-fibroblast|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ABI3BP FBN1 FN1

5.86e-0519118344a9a6768084dafc641ad455b65862bfd4cc0cb9
ToppCellE18.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2-AF2_mature|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ABI3BP FBN1 FBN2

5.86e-0519118375d2197076a9dfc868e8baf95bd4c5e44f438e3e
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Afferent_/_Efferent_Arteriole_Endothelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ABI3BP FBN1 FN1

5.86e-05191183b2c86cde341fe350143658c8a8a4a9edbce3f19b
ToppCell356C-Myeloid-Macrophage-FABP4+_Macrophage_proliferating_2|356C / Donor, Lineage, Cell class and subclass (all cells)

BUB1B C9orf40 FN1

5.86e-05191183a2c235a55094e4fd5273d764c9e2967116b48c23
Drugisodesmosine

IDE FBN1 FBN2 FN1

1.10e-0833184CID000013811
Drugdesmosine

IDE FBN1 FBN2 FN1

7.81e-0853184CID000025435
DrugGSK1210151A

BRD4 FBN1 FN1

8.95e-0652183ctd:C568713
DrugPyrithyldione [77-04-3]; Up 200; 24uM; MCF7; HT_HG-U133A

USP20 DNAH17 FBN1 FN1

1.51e-051971846801_UP
DrugTrimethylcolchicinic acid [3482-37-9]; Up 200; 11.6uM; MCF7; HT_HG-U133A

ABI3BP USP20 DNAH17 FN1

1.51e-051971842802_UP
DrugNeomycin sulfate [1405-10-3]; Up 200; 4.2uM; PC3; HT_HG-U133A

TCN1 BRD4 USP20 FBN2

1.54e-051981842066_UP
Drugaflodac

BRD4 IDE FBN2 BUB1B

5.27e-05271184CID000005352
Diseaseconnective tissue disease (implicated_via_orthology)

FBN1 FBN2

1.05e-063182DOID:65 (implicated_via_orthology)
Diseasescoliosis (is_implicated_in)

FBN1 FBN2

2.11e-064182DOID:0060249 (is_implicated_in)
Diseasesensorineural hearing loss (implicated_via_orthology)

LNX2 DNAH17

5.97e-0519182DOID:10003 (implicated_via_orthology)
Diseaseattempted suicide

IDE FBN1 CSMD1

1.65e-04178183EFO_0004321
Diseaseemphysema

DHX15 CSMD1

2.07e-0435182EFO_0000464
DiseaseFamilial thoracic aortic aneurysm and aortic dissection

FBN1 FBN2

4.75e-0453182C4707243
DiseaseMicrocephaly

BRD4 BUB1B

7.59e-0467182C0025958
Diseasejoint damage measurement

ABI3BP CSMD1

7.82e-0468182EFO_0005413
Diseasebehavioural disinhibition measurement

CSMD1 FN1

9.50e-0475182EFO_0006946
DiseaseGlioblastoma

BRD4 FN1

1.05e-0379182C0017636
Diseasealcoholic liver disease

DHX15 FBN2

1.13e-0382182EFO_0008573
DiseaseGiant Cell Glioblastoma

BRD4 FN1

1.19e-0384182C0334588

Protein segments in the cluster

PeptideGeneStartEntry
YQYQDGCIVWHQYIN

BUB1B

826

O60566
NYPVQYEDNAHCVWV

CSMD1

426

Q96PZ7
NNYYWNAQECIQDFN

BRD4

116

O60885
QNHESVQWCYDNFIN

DHX15

636

O43143
CGQQHWTRENHLYNY

LNX2

26

Q8N448
YQQWVAGVDQDCHFN

DNAH17

641

Q9UFH2
GCYDNGKHYQINQQW

FN1

51

P02751
YLQHYQWNQCVDENE

FBN1

2596

P35555
WFVYQQRNEVHNNCG

IDE

776

P14735
RQHNEEFWQYNTFQY

C9orf40

141

Q8IXQ3
QGYIQHYQWNQCVDE

FBN2

2641

P35556
QYYQEQHQNWYVIDG

AK9

1571

Q5TCS8
DYYNENDWNCQQTLN

TCN1

256

P20061
AYCQNVINGQWYEFD

USP20

646

Q9Y2K6
WKHASDQNYNYEQVN

ZNF507

806

Q8TCN5
DIQCTYGNPNYHWQE

USP18

346

Q9UMW8
IGGHTQINYVQWYEC

ABI3BP

1046

Q7Z7G0
IQYYYNQHVFAWEQN

MYO3A

741

Q8NEV4