Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionRNA polymerase II-specific DNA-binding transcription factor binding

NCOA6 GTF2H1 TCF7L2 EGR2 MED25 NCOA1 HSD17B10 ARID1A CREBBP EP300 RAD23B

4.73e-084176111GO:0061629
GeneOntologyMolecularFunctionnuclear receptor binding

NCOA6 GTF2H1 TCF7L2 MED25 NCOA1 HSD17B10 ARID1A EP300

9.81e-08187618GO:0016922
GeneOntologyMolecularFunctionchromatin binding

RAG2 NCOA6 GTF2H1 TCF7L2 EGR2 GLI3 NCOA1 RCC1 CHD8 ARID1A CREBBP EP300 MSGN1

2.80e-077396113GO:0003682
GeneOntologyMolecularFunctionDNA-binding transcription factor binding

NCOA6 GTF2H1 TCF7L2 EGR2 MED25 NCOA1 HSD17B10 ARID1A CREBBP EP300 RAD23B

1.31e-065826111GO:0140297
GeneOntologyMolecularFunctiontranscription coactivator activity

KMT2C NCOA6 KMT2D NCOA1 ARID1A SS18 CREBBP EP300

3.76e-06303618GO:0003713
GeneOntologyMolecularFunctionpeptide lactyltransferase (CoA-dependent) activity

CREBBP EP300

9.18e-062612GO:0120300
GeneOntologyMolecularFunctionhistone H3K27 acetyltransferase activity

CREBBP EP300

9.18e-062612GO:0044017
GeneOntologyMolecularFunctiontranscription factor binding

NCOA6 GTF2H1 TCF7L2 EGR2 MED25 NCOA1 HSD17B10 ARID1A CREBBP EP300 RAD23B

1.52e-057536111GO:0008134
GeneOntologyMolecularFunctionhistone H3K18 acetyltransferase activity

CREBBP EP300

2.75e-053612GO:0043993
GeneOntologyMolecularFunctionperoxisome proliferator activated receptor binding

NCOA6 CREBBP EP300

3.47e-0521613GO:0042975
GeneOntologyMolecularFunctionnuclear retinoid X receptor binding

NCOA6 MED25 NCOA1

4.60e-0523613GO:0046965
GeneOntologyMolecularFunctiontranscription coregulator activity

KMT2C NCOA6 KMT2D NCOA1 GON4L ARID1A SS18 CREBBP EP300

4.89e-05562619GO:0003712
GeneOntologyMolecularFunctionhistone modifying activity

KMT2C KMT2D RPS6KA4 NCOA1 CREBBP EP300

6.99e-05229616GO:0140993
GeneOntologyMolecularFunctionRNA polymerase II transcription regulatory region sequence-specific DNA binding

HEYL POU6F2 TCF7L2 ZNF628 EGR2 ZNF41 ZNF174 GLI3 NCOA1 RHOXF1 CREBBP EP300 MSGN1 RAD23B

1.00e-0414596114GO:0000977
GeneOntologyMolecularFunctionhistone H3K4 monomethyltransferase activity

KMT2C KMT2D

2.54e-048612GO:0140945
GeneOntologyMolecularFunctionacetyltransferase activity

ACAT1 NCOA1 CREBBP EP300

2.88e-04104614GO:0016407
GeneOntologyMolecularFunctionarmadillo repeat domain binding

TCF7L2 CHD8

3.26e-049612GO:0070016
GeneOntologyMolecularFunctionhistone H3K4 trimethyltransferase activity

KMT2C KMT2D

4.07e-0410612GO:0140999
GeneOntologyMolecularFunctionbeta-catenin binding

TCF7L2 GLI3 CHD8 EP300

4.97e-04120614GO:0008013
GeneOntologyMolecularFunctionhistone acetyltransferase activity

NCOA1 CREBBP EP300

5.09e-0451613GO:0004402
GeneOntologyMolecularFunctionnuclear estrogen receptor binding

NCOA6 NCOA1 HSD17B10

5.70e-0453613GO:0030331
GeneOntologyMolecularFunctiontranscription coactivator binding

MED25 CREBBP EP300

6.02e-0454613GO:0001223
GeneOntologyMolecularFunctionpeptide-lysine-N-acetyltransferase activity

NCOA1 CREBBP EP300

6.36e-0455613GO:0061733
GeneOntologyMolecularFunctionnuclear retinoic acid receptor binding

NCOA6 MED25 NCOA1

6.36e-0455613GO:0042974
GeneOntologyMolecularFunctionpeptide N-acetyltransferase activity

NCOA1 CREBBP EP300

8.20e-0460613GO:0034212
GeneOntologyMolecularFunctionnuclear receptor coactivator activity

NCOA6 NCOA1 SS18

8.61e-0461613GO:0030374
GeneOntologyMolecularFunctionhistone H3 acetyltransferase activity

CREBBP EP300

9.40e-0415612GO:0010484
GeneOntologyMolecularFunctionRNA polymerase II cis-regulatory region sequence-specific DNA binding

HEYL POU6F2 TCF7L2 ZNF628 EGR2 ZNF41 ZNF174 GLI3 EP300 MSGN1 RAD23B

1.23e-0312446111GO:0000978
GeneOntologyMolecularFunctionprotein domain specific binding

HEYL NCOA6 TCF7L2 EGR2 PLEKHA2 CHD8 CREBBP RCC2 DDX6

1.28e-03875619GO:0019904
GeneOntologyMolecularFunctioncis-regulatory region sequence-specific DNA binding

HEYL POU6F2 TCF7L2 ZNF628 EGR2 ZNF41 ZNF174 GLI3 EP300 MSGN1 RAD23B

1.46e-0312716111GO:0000987
GeneOntologyMolecularFunctionnuclear glucocorticoid receptor binding

NCOA6 EP300

1.68e-0320612GO:0035259
GeneOntologyMolecularFunctionhistone H3K4 methyltransferase activity

KMT2C KMT2D

1.68e-0320612GO:0042800
GeneOntologyMolecularFunctionp53 binding

CHD8 CREBBP EP300

1.69e-0377613GO:0002039
GeneOntologyMolecularFunctionN-acetyltransferase activity

NCOA1 CREBBP EP300

1.75e-0378613GO:0008080
GeneOntologyMolecularFunctiondamaged DNA binding

CREBBP EP300 RAD23B

2.17e-0384613GO:0003684
GeneOntologyMolecularFunctionprotein-macromolecule adaptor activity

KMT2C NCOA6 KMT2D TNRC6A NCOA1 GON4L ARID1A SS18 CREBBP EP300

2.53e-0311606110GO:0030674
GeneOntologyMolecularFunctionDNA-binding transcription factor activity, RNA polymerase II-specific

HEYL POU6F2 KMT2D TCF7L2 ZNF628 EGR2 ZNF41 ZNF174 GLI3 RHOXF1 MSGN1

3.35e-0314126111GO:0000981
GeneOntologyMolecularFunctionmodification-dependent protein binding

RAG2 CHD8 EP300 RAD23B

3.63e-03206614GO:0140030
GeneOntologyMolecularFunctionN-acyltransferase activity

NCOA1 CREBBP EP300

3.76e-03102613GO:0016410
GeneOntologyMolecularFunctionnuclear thyroid hormone receptor binding

NCOA6 GTF2H1

4.84e-0334612GO:0046966
GeneOntologyMolecularFunctionphosphatidylinositol-3,4-bisphosphate binding

RAG2 PLEKHA2

5.12e-0335612GO:0043325
GeneOntologyMolecularFunctionbHLH transcription factor binding

CREBBP EP300

5.71e-0337612GO:0043425
GeneOntologyMolecularFunctionATP-dependent chromatin remodeler activity

CHD8 ARID1A

5.71e-0337612GO:0140658
GeneOntologyMolecularFunctionacyltransferase activity, transferring groups other than amino-acyl groups

ACAT1 NCOA1 CREBBP EP300

6.04e-03238614GO:0016747
GeneOntologyMolecularFunctionATP-dependent activity, acting on DNA

RTEL1 CHD8 ARID1A

6.91e-03127613GO:0008094
GeneOntologyMolecularFunctionDNA-binding transcription activator activity, RNA polymerase II-specific

HEYL KMT2D TCF7L2 ZNF628 EGR2 MSGN1

7.13e-03560616GO:0001228
GeneOntologyMolecularFunctionDNA-binding transcription activator activity

HEYL KMT2D TCF7L2 ZNF628 EGR2 MSGN1

7.50e-03566616GO:0001216
GeneOntologyMolecularFunctionmolecular adaptor activity

KMT2C NCOA6 KMT2D TNRC6A NCOA1 GON4L ARID1A SS18 CREBBP EP300

7.60e-0313566110GO:0060090
GeneOntologyMolecularFunctionhistone H3 methyltransferase activity

KMT2C KMT2D

8.00e-0344612GO:0140938
GeneOntologyMolecularFunctiontranscription coregulator binding

MED25 CREBBP EP300

9.03e-03140613GO:0001221
GeneOntologyMolecularFunctionacyltransferase activity

RAG2 KMT2C ACAT1 EGR2 NCOA1 CREBBP EP300

9.13e-03775617GO:0016746
GeneOntologyBiologicalProcessembryo development

NCOA6 KMT2D TCF7L2 ABL2 GLI3 MATR3 MFN2 NCOA1 CHD8 TNRC6C ARID1A CREBBP EP300 RYR2 MSGN1 RAD23B

2.87e-0614376116GO:0009790
GeneOntologyBiologicalProcesspositive regulation of transcription by RNA polymerase II

HEYL KMT2C NCOA6 KMT2D TCF7L2 RPS6KA4 EGR2 GLI3 MED25 NCOA1 CHD8 SS18 CREBBP EP300 MSGN1

9.20e-0613906115GO:0045944
GeneOntologyBiologicalProcesschordate embryonic development

NCOA6 KMT2D TCF7L2 ABL2 GLI3 MATR3 MFN2 NCOA1 CHD8 ARID1A EP300 MSGN1

1.14e-059066112GO:0043009
GeneOntologyBiologicalProcessembryo development ending in birth or egg hatching

NCOA6 KMT2D TCF7L2 ABL2 GLI3 MATR3 MFN2 NCOA1 CHD8 ARID1A EP300 MSGN1

1.47e-059296112GO:0009792
GeneOntologyBiologicalProcessN-terminal peptidyl-lysine acetylation

CREBBP EP300

5.14e-054612GO:0018076
GeneOntologyBiologicalProcesshead development

NCOA6 TCF7L2 ABL2 EGR2 GLI3 NCOA1 CHD8 ARID1A CREBBP EP300 WDR47

7.01e-059196111GO:0060322
GeneOntologyBiologicalProcessstem cell population maintenance

TCF7L2 ARID1A SS18 CREBBP DDX6 WDR47

7.07e-05237616GO:0019827
GeneOntologyBiologicalProcessmaintenance of cell number

TCF7L2 ARID1A SS18 CREBBP DDX6 WDR47

7.94e-05242616GO:0098727
GeneOntologyBiologicalProcesshormone-mediated signaling pathway

HEYL GTF2H1 KMT2D NCOA1 ARID1A EP300

8.31e-05244616GO:0009755
GeneOntologyBiologicalProcessisoleucine catabolic process

ACAT1 HSD17B10

8.55e-055612GO:0006550
GeneOntologyBiologicalProcessprotein-DNA complex organization

RAG2 KMT2C KMT2D RPS6KA4 MED25 NCOA1 CHD8 ARID1A SS18 CREBBP EP300

1.47e-049996111GO:0071824
GeneOntologyBiologicalProcessresponse to hormone

HEYL NCOA6 GTF2H1 KMT2D ACAT1 EGR2 MFN2 NCOA1 ARID1A MEAK7 EP300

2.12e-0410426111GO:0009725
GeneOntologyBiologicalProcessembryonic morphogenesis

TCF7L2 ABL2 GLI3 NCOA1 TNRC6C ARID1A CREBBP RYR2 MSGN1

2.33e-04713619GO:0048598
GeneOntologyBiologicalProcessembryonic organ development

NCOA6 TCF7L2 GLI3 NCOA1 TNRC6C ARID1A RYR2 RAD23B

2.36e-04561618GO:0048568
GeneOntologyBiologicalProcessisoleucine metabolic process

ACAT1 HSD17B10

2.38e-048612GO:0006549
GeneOntologyBiologicalProcessface morphogenesis

TCF7L2 CREBBP EP300

2.42e-0441613GO:0060325
GeneOntologyBiologicalProcessT cell lineage commitment

CYLD RAG2 EP300

2.60e-0442613GO:0002360
GeneOntologyBiologicalProcesschromatin organization

RAG2 KMT2C KMT2D RPS6KA4 NCOA1 CHD8 ARID1A SS18 CREBBP EP300

2.74e-048966110GO:0006325
GeneOntologyBiologicalProcesshindgut morphogenesis

TCF7L2 GLI3

3.06e-049612GO:0007442
GeneOntologyBiologicalProcesschromatin remodeling

KMT2C KMT2D RPS6KA4 NCOA1 CHD8 ARID1A SS18 CREBBP EP300

3.09e-04741619GO:0006338
GeneOntologyBiologicalProcessnuclear receptor-mediated signaling pathway

HEYL KMT2D NCOA1 ARID1A EP300

3.27e-04202615GO:0141193
GeneOntologyBiologicalProcessin utero embryonic development

NCOA6 KMT2D TCF7L2 GLI3 MATR3 MFN2 NCOA1 CHD8

3.54e-04596618GO:0001701
GeneOntologyBiologicalProcesspositive regulation of protein localization to nucleus

TCF7L2 GLI3 CREBBP EP300

3.62e-04114614GO:1900182
GeneOntologyBiologicalProcesshindgut development

TCF7L2 GLI3

3.81e-0410612GO:0061525
GeneOntologyBiologicalProcessproximal tubule development

HEYL ACAT1

3.81e-0410612GO:0072014
GeneOntologyBiologicalProcesshead morphogenesis

TCF7L2 CREBBP EP300

3.87e-0448613GO:0060323
GeneOntologyBiologicalProcessandrogen receptor signaling pathway

HEYL ARID1A EP300

4.63e-0451613GO:0030521
GeneOntologyBiologicalProcessregulation of T cell differentiation

CYLD RAG2 GLI3 ARID1A EP300

5.46e-04226615GO:0045580
GeneOntologyBiologicalProcessDNA-templated transcription initiation

NCOA6 GTF2H1 MED25 ARID1A EP300

6.03e-04231615GO:0006352
GeneOntologyBiologicalProcessregulation of sarcomere organization

MFN2 EP300

6.57e-0413612GO:0060297
GeneOntologyCellularComponentchromatin

HEYL POU6F2 TCF7L2 EGR2 ZNF174 NCOA1 GON4L RCC1 CHD8 RHOXF1 ARID1A SS18 CREBBP EP300 DDX6 MSGN1

4.45e-0614806216GO:0000785
GeneOntologyCellularComponentMLL3/4 complex

KMT2C NCOA6 KMT2D

5.36e-0612623GO:0044666
GeneOntologyCellularComponentnuclear protein-containing complex

KMT2C NCOA6 GTF2H1 KMT2D TCF7L2 MED25 NCOA1 GON4L CHD8 NUP188 ARID1A SS18 CREBBP CSTF2T RAD23B

8.67e-0613776215GO:0140513
GeneOntologyCellularComponentmethyltransferase complex

KMT2C NCOA6 KMT2D CHD8 HSD17B10

1.72e-05108625GO:0034708
GeneOntologyCellularComponenttranscription regulator complex

HEYL NCOA6 GTF2H1 TCF7L2 GLI3 MED25 NCOA1 CREBBP EP300

6.18e-05596629GO:0005667
GeneOntologyCellularComponenthistone methyltransferase complex

KMT2C NCOA6 KMT2D CHD8

7.28e-0575624GO:0035097
GeneOntologyCellularComponentnpBAF complex

ARID1A SS18

7.70e-0414622GO:0071564
GeneOntologyCellularComponentRNA polymerase II transcription regulator complex

GTF2H1 TCF7L2 MED25 NCOA1 CREBBP

1.27e-03272625GO:0090575
HumanPhenoNatal tooth

KMT2C KMT2D GLI3 CREBBP EP300

2.19e-0638305HP:0000695
HumanPhenoAdvanced eruption of teeth

KMT2C KMT2D GLI3 CREBBP EP300

5.79e-0646305HP:0006288
HumanPhenoToe deformity

EGR2 GLI3 MED25 MFN2 CREBBP EP300 DDX6

7.11e-06129307HP:0034398
HumanPhenoPilomatrixoma

KMT2D CREBBP EP300

1.51e-059303HP:0030434
HumanPhenoAbnormal subclavian artery morphology

CREBBP EP300 DDX6

2.95e-0511303HP:0031251
HumanPhenoPlantar crease between first and second toes

CREBBP EP300

3.35e-052302HP:0008107
HumanPhenoAortic isthmus hypoplasia

CREBBP EP300

3.35e-052302HP:0034227
HumanPhenoHigh axial triradius

CREBBP EP300

3.35e-052302HP:0001042
HumanPhenoFacial grimacing

GLI3 CREBBP EP300

5.07e-0513303HP:0000273
HumanPhenoOverlapping toe

GLI3 MED25 CREBBP EP300 DDX6

5.31e-0572305HP:0001845
HumanPhenoLaryngeal cartilage malformation

CREBBP EP300

1.00e-043302HP:0008752
HumanPhenoPhobia

CREBBP EP300

1.00e-043302HP:5200232
HumanPhenoAgoraphobia

CREBBP EP300

1.00e-043302HP:0000756
HumanPhenoHumoral immunodeficiency

CREBBP EP300

1.00e-043302HP:0005363
HumanPhenoProminent nasal septum

CREBBP EP300

1.00e-043302HP:0005322
HumanPhenoRadial deviation of thumb terminal phalanx

CREBBP EP300

1.00e-043302HP:0005895
HumanPhenoSupernumerary tooth

KMT2C KMT2D GLI3 CREBBP EP300

1.18e-0485305HP:0011069
HumanPhenoPremature thelarche

KMT2D CREBBP EP300

1.19e-0417303HP:0010314
HumanPhenoSkin appendage neoplasm

KMT2D CREBBP EP300

1.42e-0418303HP:0012842
HumanPhenoBroad phalanx of the toes

GLI3 MED25 CREBBP EP300

1.46e-0447304HP:0010174
HumanPhenoTrichiasis

CREBBP EP300

2.00e-044302HP:0001128
HumanPhenoVisceral hemangioma

CREBBP EP300

2.00e-044302HP:0410266
HumanPhenoTalon cusp

CREBBP EP300

2.00e-044302HP:0011087
HumanPhenoFoot pain

COL9A2 MFN2

2.00e-044302HP:0025238
HumanPhenoWidened distal phalanges

CREBBP EP300

2.00e-044302HP:0006200
HumanPhenoVascular ring

CREBBP EP300

2.00e-044302HP:0010775
HumanPhenoHepatic hemangioma

CREBBP EP300

2.00e-044302HP:0031207
HumanPhenoAbnormal eyebrow morphology

RAG2 KMT2C KMT2D RTEL1 MED25 CHD8 NUP188 ARID1A CREBBP KRT25 EP300 DDX6

2.31e-046743012HP:0000534
HumanPhenoInguinal hernia

KMT2C MBTPS1 KMT2D GLI3 MED25 ARID1A CREBBP DDX6

3.23e-04312308HP:0000023
HumanPhenoIncreased laxity of ankles

GLI3 MFN2

3.32e-045302HP:0006460
HumanPhenoPapillary cystadenoma of the epididymis

CREBBP EP300

3.32e-045302HP:0009715
HumanPhenoSupernumerary cusp

CREBBP EP300

3.32e-045302HP:0033777
HumanPhenoEpididymal neoplasm

CREBBP EP300

3.32e-045302HP:0030421
HumanPhenoBroad hallux phalanx

GLI3 CREBBP EP300

3.43e-0424303HP:0010059
HumanPhenoPerimembranous ventricular septal defect

NUP188 CREBBP EP300

4.37e-0426303HP:0011682
HumanPhenoLarge foramen magnum

CREBBP EP300

4.96e-046302HP:0002700
HumanPhenoAbnormality of the helix

KMT2D ACBD5 NUP188 CREBBP EP300 DDX6

5.72e-04183306HP:0000380
HumanPhenoShort columella

KMT2D CREBBP EP300

6.08e-0429303HP:0002000
HumanPhenoPreaxial foot polydactyly

GLI3 CREBBP EP300

6.72e-0430303HP:0001841
HumanPhenoDeviated nasal septum

CREBBP EP300

6.91e-047302HP:0004411
HumanPhenoAbnormal lateral ventricle morphology

KMT2D MED25 CREBBP D2HGDH EP300

8.26e-04129305HP:0030047
MousePhenoembryonic lethality during organogenesis

NCOA6 KMT2D RTEL1 GLI3 TNRC6A MFN2 CHD8 ARID1A CREBBP EP300 RYR2 DDX6 MSGN1

1.69e-058765313MP:0006207
MousePhenoabnormal epicardium morphology

NCOA6 EP300 RYR2

3.37e-0517533MP:0003057
MousePhenoembryonic lethality during organogenesis, complete penetrance

NCOA6 KMT2D RTEL1 TNRC6A CHD8 ARID1A CREBBP EP300 RYR2 DDX6 MSGN1

5.09e-057005311MP:0011098
MousePhenoabnormal pulmonary valve cusp morphology

TCF7L2 EGR2 MATR3

1.12e-0425533MP:0010602
MousePhenoembryonic lethality, incomplete penetrance

KMT2C NCOA6 GLI3 MATR3 TNRC6A MFN2 CREBBP EP300

1.43e-04410538MP:0011102
MousePhenoprenatal lethality prior to heart atrial septation, incomplete penetrance

KMT2C NCOA6 GLI3 MATR3 TNRC6A MFN2 CREBBP EP300

1.43e-04410538MP:0031660
MousePhenoabnormal grooming behavior

BEX3 KMT2D CHD8 CREBBP RAD23B

1.65e-04137535MP:0001440
MousePhenoincreased grooming behavior

BEX3 KMT2D CHD8 CREBBP

1.74e-0474534MP:0001441
MousePhenoabnormal intestinal epithelium morphology

CYLD RAG2 TCF7L2 EP300

1.83e-0475534MP:0000488
MousePhenoabnormal pericardium morphology

NCOA6 RTEL1 GLI3 ARID1A EP300 RYR2

1.99e-04225536MP:0000288
MousePhenoabnormal neuropore morphology

RTEL1 GLI3 CREBBP MSGN1

2.03e-0477534MP:0012542
MousePhenoenlarged frontal bone

BEX3 CREBBP

2.93e-047532MP:0004375
MousePhenoabnormal neural tube morphology

RTEL1 EGR2 GLI3 ARID1A SS18 CREBBP EP300 DDX6 MSGN1

3.40e-04591539MP:0002151
MousePhenoabnormal germ layer morphology

RTEL1 GLI3 CHD8 ARID1A MSGN1

3.50e-04161535MP:0014138
MousePhenoperimembraneous ventricular septal defect

TCF7L2 MATR3 CREBBP EP300

4.02e-0492534MP:0010418
MousePhenoabnormal interventricular septum membranous part morphology

TCF7L2 MATR3 CREBBP EP300

4.19e-0493534MP:0008823
DomainNuc_rcpt_coact

NCOA1 CREBBP EP300

6.92e-076623IPR009110
DomainNuc_rcpt_coact_CREBbp

CREBBP EP300

1.08e-052622IPR014744
DomainHAT_KAT11

CREBBP EP300

1.08e-052622PF08214
DomainKIX

CREBBP EP300

1.08e-052622PS50952
DomainZnF_TAZ

CREBBP EP300

1.08e-052622SM00551
DomainM_domain

TNRC6A TNRC6C

1.08e-052622PF12938
DomainCBP_P300_HAT

CREBBP EP300

1.08e-052622IPR031162
DomainDUF902

CREBBP EP300

1.08e-052622PF06001
DomainGW182_M_dom

TNRC6A TNRC6C

1.08e-052622IPR026805
Domain-

CREBBP EP300

1.08e-0526221.20.1020.10
DomainRING_CBP-p300

CREBBP EP300

1.08e-052622IPR010303
Domain-

CREBBP EP300

1.08e-0526221.10.1630.10
DomainCreb_binding

CREBBP EP300

1.08e-052622PF09030
Domain-

CREBBP EP300

1.08e-0526221.10.246.20
Domainzf-TAZ

CREBBP EP300

1.08e-052622PF02135
DomainZF_TAZ

CREBBP EP300

1.08e-052622PS50134
DomainHistone_AcTrfase_Rtt109/CBP

CREBBP EP300

1.08e-052622IPR013178
DomainKAT11

CREBBP EP300

1.08e-052622SM01250
DomainZnf_TAZ

CREBBP EP300

1.08e-052622IPR000197
DomainKIX_dom

CREBBP EP300

1.08e-052622IPR003101
DomainKIX

CREBBP EP300

1.08e-052622PF02172
DomainCBP_P300_HAT

CREBBP EP300

1.08e-052622PS51727
DomainAgo_hook

TNRC6A TNRC6C

3.25e-053622PF10427
DomainTNRC6_PABC-bd

TNRC6A TNRC6C

3.25e-053622IPR032226
DomainArgonaute_hook_dom

TNRC6A TNRC6C

3.25e-053622IPR019486
DomainTNRC6-PABC_bdg

TNRC6A TNRC6C

3.25e-053622PF16608
DomainFYrich_C

KMT2C KMT2D

1.08e-045622IPR003889
DomainFYrich_N

KMT2C KMT2D

1.08e-045622IPR003888
DomainFYRC

KMT2C KMT2D

1.08e-045622SM00542
DomainFYRN

KMT2C KMT2D

1.08e-045622SM00541
DomainFYRN

KMT2C KMT2D

1.08e-045622PF05964
DomainFYRC

KMT2C KMT2D

1.08e-045622PF05965
DomainFYRC

KMT2C KMT2D

1.08e-045622PS51543
DomainFYRN

KMT2C KMT2D

1.08e-045622PS51542
DomainKeratin_I

KRT26 KRT27 KRT25

4.19e-0444623IPR002957
DomainHMG_box

KMT2C KMT2D TCF7L2

7.25e-0453623PF00505
DomainHMG

KMT2C KMT2D TCF7L2

7.66e-0454623SM00398
DomainUBA-like

TNRC6A TNRC6C RAD23B

1.26e-0364623IPR009060
DomainPost-SET_dom

KMT2C KMT2D

1.26e-0316622IPR003616
DomainPostSET

KMT2C KMT2D

1.26e-0316622SM00508
DomainPOST_SET

KMT2C KMT2D

1.26e-0316622PS50868
DomainHMG_box_dom

KMT2C KMT2D TCF7L2

1.31e-0365623IPR009071
DomainZZ

CREBBP EP300

1.60e-0318622PF00569
DomainZF_ZZ_2

CREBBP EP300

1.60e-0318622PS50135
DomainZF_ZZ_1

CREBBP EP300

1.60e-0318622PS01357
DomainFilament

KRT26 KRT27 KRT25

1.70e-0371623SM01391
DomainIF

KRT26 KRT27 KRT25

1.77e-0372623PS00226
DomainZnf_ZZ

CREBBP EP300

1.79e-0319622IPR000433
DomainZnF_ZZ

CREBBP EP300

1.79e-0319622SM00291
DomainFilament

KRT26 KRT27 KRT25

1.84e-0373623PF00038
DomainRCC1

RCC1 RCC2

1.98e-0320622PF00415
DomainIF

KRT26 KRT27 KRT25

2.06e-0376623IPR001664
DomainRCC1_1

RCC1 RCC2

2.19e-0321622PS00625
DomainRCC1_2

RCC1 RCC2

2.19e-0321622PS00626
DomainRCC1_3

RCC1 RCC2

2.19e-0321622PS50012
DomainEPHD

KMT2C KMT2D

2.40e-0322622PS51805
DomainReg_chr_condens

RCC1 RCC2

2.40e-0322622IPR000408
Domain-

RCC1 RCC2

2.40e-03226222.130.10.30
DomainRCC1/BLIP-II

RCC1 RCC2

2.62e-0323622IPR009091
DomainBromodomain_CS

CREBBP EP300

3.35e-0326622IPR018359
DomainZF_PHD_2

RAG2 KMT2C KMT2D

3.88e-0395623PS50016
DomainZF_PHD_1

RAG2 KMT2C KMT2D

4.00e-0396623PS01359
DomainUBA

TNRC6C RAD23B

4.44e-0330622SM00165
DomainPAS

NCOA1 KCNH4

5.04e-0332622SM00091
DomainPAS

NCOA1 KCNH4

5.68e-0334622IPR000014
DomainPAS

NCOA1 KCNH4

5.68e-0334622PS50112
Domain-

HEYL NCOA1 MSGN1

5.70e-031096234.10.280.10
DomainRRM

MATR3 TNRC6A TNRC6C CSTF2T

5.84e-03217624SM00360
PathwayREACTOME_DEVELOPMENTAL_BIOLOGY

KMT2C KRT26 NCOA6 COL9A2 KMT2D TCF7L2 RPS6KA4 ABL2 EGR2 KRT27 TNRC6A MED25 NCOA1 TNRC6C ARID1A SS18 CREBBP KRT25 EP300 MSGN1

2.84e-0814325020M509
PathwayREACTOME_RORA_ACTIVATES_GENE_EXPRESSION

NCOA6 NCOA1 CREBBP EP300

4.13e-0718504M26942
PathwayREACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION

NCOA6 EGR2 MED25 NCOA1 CREBBP EP300

4.81e-0784506M1008
PathwayBIOCARTA_VDR_PATHWAY

NCOA1 ARID1A CREBBP EP300

1.41e-0624504M13404
PathwayBIOCARTA_PPARG_PATHWAY

NCOA1 CREBBP EP300

2.32e-068503M22058
PathwayREACTOME_ADIPOGENESIS

NCOA6 EGR2 MED25 NCOA1 CREBBP EP300

2.37e-06110506M48259
PathwayREACTOME_ACTIVATION_OF_ANTERIOR_HOX_GENES_IN_HINDBRAIN_DEVELOPMENT_DURING_EARLY_EMBRYOGENESIS

KMT2C NCOA6 KMT2D EGR2 CREBBP EP300

4.32e-06122506M29689
PathwayREACTOME_MITF_M_REGULATED_MELANOCYTE_DEVELOPMENT

TCF7L2 TNRC6A TNRC6C ARID1A SS18 CREBBP

8.44e-06137506M48232
PathwayREACTOME_NR1H3_NR1H2_REGULATE_GENE_EXPRESSION_LINKED_TO_CHOLESTEROL_TRANSPORT_AND_EFFLUX

TNRC6A NCOA1 TNRC6C EP300

8.48e-0637504M29790
PathwayREACTOME_TRANSCRIPTIONAL_REGULATION_BY_RUNX1

KMT2C KMT2D TNRC6A TNRC6C ARID1A CREBBP EP300

1.88e-05237507M27786
PathwayREACTOME_MITF_M_DEPENDENT_GENE_EXPRESSION

TCF7L2 TNRC6A TNRC6C ARID1A SS18

2.08e-0595505M48268
PathwayREACTOME_RUNX1_REGULATES_GENES_INVOLVED_IN_MEGAKARYOCYTE_DIFFERENTIATION_AND_PLATELET_FUNCTION

KMT2C KMT2D TNRC6A TNRC6C EP300

2.19e-0596505M27792
PathwayREACTOME_NR1H2_AND_NR1H3_MEDIATED_SIGNALING

TNRC6A NCOA1 TNRC6C EP300

2.23e-0547504M29777
PathwayREACTOME_HEME_SIGNALING

NCOA6 NCOA1 CREBBP EP300

2.64e-0549504M41832
PathwayREACTOME_EPIGENETIC_REGULATION_OF_GENE_EXPRESSION

KMT2C NCOA6 GTF2H1 KMT2D ARID1A SS18 EP300

2.93e-05254507M27131
PathwayREACTOME_REGULATION_OF_CHOLESTEROL_BIOSYNTHESIS_BY_SREBP_SREBF

NCOA6 MBTPS1 NCOA1 CREBBP

4.18e-0555504M27001
PathwayREACTOME_REGULATION_OF_LIPID_METABOLISM_BY_PPARALPHA

NCOA6 MED25 NCOA1 CREBBP EP300

5.92e-05118505M27316
PathwayBIOCARTA_VDR_PATHWAY

ARID1A CREBBP EP300

6.17e-0522503MM1370
PathwayWP_PATHWAYS_AFFECTED_IN_ADENOID_CYSTIC_CARCINOMA

KMT2C ARID1A CREBBP EP300

8.08e-0565504M39682
PathwayREACTOME_NOTCH3_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION

HEYL CREBBP EP300

9.14e-0525503M27880
PathwayREACTOME_FORMATION_OF_THE_BETA_CATENIN_TCF_TRANSACTIVATING_COMPLEX

KMT2D TCF7L2 EP300

1.03e-0426503MM14793
PathwayREACTOME_CIRCADIAN_CLOCK

NCOA6 NCOA1 CREBBP EP300

1.08e-0470504M938
PathwayREACTOME_BMAL1_CLOCK_NPAS2_ACTIVATES_CIRCADIAN_GENE_EXPRESSION

NCOA6 NCOA1 CREBBP

1.16e-0427503M26943
PathwayBIOCARTA_PELP1_PATHWAY

CREBBP EP300

1.22e-045502MM1575
PathwayREACTOME_NFE2L2_REGULATING_INFLAMMATION_ASSOCIATED_GENES

CREBBP EP300

1.22e-045502M48020
PathwayREACTOME_NFE2L2_REGULATING_ER_STRESS_ASSOCIATED_GENES

CREBBP EP300

1.22e-045502M48023
PathwayREACTOME_LRR_FLII_INTERACTING_PROTEIN_1_LRRFIP1_ACTIVATES_TYPE_I_IFN_PRODUCTION

CREBBP EP300

1.22e-045502M27228
PathwayREACTOME_TGFBR3_EXPRESSION

TNRC6A TNRC6C EP300

1.29e-0428503M48253
PathwayWP_KLEEFSTRA_SYNDROME

KMT2C NCOA6 ARID1A

1.44e-0429503M48076
PathwayREACTOME_SIGNALING_BY_WNT

KMT2D TCF7L2 TNRC6A CHD8 TNRC6C CREBBP EP300

1.52e-04330507M7847
PathwayPID_RETINOIC_ACID_PATHWAY

NCOA1 CREBBP EP300

1.59e-0430503M207
PathwayREACTOME_ESTROGEN_DEPENDENT_GENE_EXPRESSION

TNRC6A NCOA1 TNRC6C CREBBP EP300

1.78e-04149505M27888
PathwayBIOCARTA_PELP1_PATHWAY

CREBBP EP300

1.83e-046502M22062
PathwayREACTOME_REGULATION_OF_HOMOTYPIC_CELL_CELL_ADHESION

HEYL TNRC6A TNRC6C

1.94e-0432503M48012
PathwayREACTOME_TRANSCRIPTIONAL_REGULATION_BY_NPAS4

TNRC6A TNRC6C CREBBP

2.33e-0434503M46422
PathwayBIOCARTA_PPARG_PATHWAY

CREBBP EP300

2.56e-047502MM1573
PathwayREACTOME_POST_TRANSCRIPTIONAL_SILENCING_BY_SMALL_RNAS

TNRC6A TNRC6C

2.56e-047502M46421
PathwayREACTOME_METABOLISM_OF_LIPIDS

NCOA6 MBTPS1 ACAT1 ACBD5 MED25 NCOA1 PLEKHA2 GLB1L2 CREBBP EP300

2.73e-047575010M27451
PathwayREACTOME_FORMATION_OF_THE_BETA_CATENIN_TCF_TRANSACTIVATING_COMPLEX

KMT2D TCF7L2 CREBBP EP300

2.98e-0491504M27101
PathwayREACTOME_NFE2L2_REGULATING_MDR_ASSOCIATED_ENZYMES

CREBBP EP300

3.41e-048502M48022
PathwayREACTOME_REGULATION_OF_NFE2L2_GENE_EXPRESSION

CREBBP EP300

3.41e-048502M48024
PathwayREACTOME_NFE2L2_REGULATES_PENTOSE_PHOSPHATE_PATHWAY_GENES

CREBBP EP300

3.41e-048502M46443
PathwayREACTOME_CHROMATIN_MODIFYING_ENZYMES

KMT2C KMT2D NCOA1 ARID1A CREBBP EP300

3.81e-04272506M29619
PathwayREACTOME_TRANSCRIPTIONAL_REGULATION_BY_VENTX

TCF7L2 TNRC6A TNRC6C

4.07e-0441503M29748
PathwayREACTOME_REGULATION_OF_PTEN_MRNA_TRANSLATION

TNRC6A TNRC6C

4.37e-049502M27810
PathwayKEGG_MEDICUS_REFERENCE_TLR3_IRF3_SIGNALING_PATHWAY

CREBBP EP300

4.37e-049502M47451
PathwayREACTOME_REGULATION_OF_NPAS4_MRNA_TRANSLATION

TNRC6A TNRC6C

4.37e-049502M46436
PathwayREACTOME_FORMATION_OF_WDR5_CONTAINING_HISTONE_MODIFYING_COMPLEXES

KMT2C NCOA6 KMT2D

4.37e-0442503M48018
PathwayREACTOME_ACTIVATION_OF_GENE_EXPRESSION_BY_SREBF_SREBP

NCOA6 NCOA1 CREBBP

4.37e-0442503M27172
PathwayREACTOME_DEACTIVATION_OF_THE_BETA_CATENIN_TRANSACTIVATING_COMPLEX

KMT2D TCF7L2 CHD8

4.37e-0442503M27272
PathwayREACTOME_SUMOYLATION_OF_TRANSCRIPTION_COFACTORS

NCOA1 CREBBP EP300

5.02e-0444503M27295
PathwayREACTOME_REGULATION_OF_CDH11_MRNA_TRANSLATION_BY_MICRORNAS

TNRC6A TNRC6C

5.45e-0410502M48013
PathwayREACTOME_REGULATION_OF_FOXO_TRANSCRIPTIONAL_ACTIVITY_BY_ACETYLATION

CREBBP EP300

5.45e-0410502M27945
PathwayPID_HES_HEY_PATHWAY

NCOA1 CREBBP EP300

6.49e-0448503M288
PathwayREACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION

HEYL CREBBP EP300

6.49e-0448503M611
PathwayBIOCARTA_CARM1_PATHWAY

CREBBP EP300

6.64e-0411502MM1521
PathwayREACTOME_NFE2L2_REGULATING_TUMORIGENIC_GENES

CREBBP EP300

6.64e-0411502M48021
PathwayREACTOME_REGULATION_OF_GENE_EXPRESSION_BY_HYPOXIA_INDUCIBLE_FACTOR

CREBBP EP300

6.64e-0411502M26924
PathwayREACTOME_SIGNALING_BY_TGFBR3

TNRC6A TNRC6C EP300

6.90e-0449503M48250
PathwayREACTOME_SIGNALING_BY_NOTCH3

HEYL CREBBP EP300

6.90e-0449503M618
PathwayBIOCARTA_CARM1_PATHWAY

CREBBP EP300

7.95e-0412502M7968
PathwayREACTOME_ACTIVATION_OF_THE_TFAP2_AP_2_FAMILY_OF_TRANSCRIPTION_FACTORS

CREBBP EP300

7.95e-0412502M27765
PathwayBIOCARTA_PPARA_PATHWAY

NCOA1 CREBBP EP300

8.21e-0452503M2404
PathwayREACTOME_PRE_NOTCH_EXPRESSION_AND_PROCESSING

TNRC6A TNRC6C CREBBP EP300

8.24e-04119504M607
PathwayREACTOME_RNA_POLYMERASE_II_TRANSCRIPTION

KMT2C GTF2H1 KMT2D TCF7L2 ZNF41 GLI3 TNRC6A MED25 TNRC6C ARID1A CREBBP EP300 CSTF2T

8.42e-0413875013M734
PathwayPID_AR_TF_PATHWAY

NCOA1 CREBBP EP300

8.68e-0453503M151
PathwayREACTOME_REGULATION_OF_NPAS4_GENE_EXPRESSION

TNRC6A TNRC6C

9.38e-0413502M46434
PathwayREACTOME_NR1H2_AND_NR1H3_MEDIATED_SIGNALING

NCOA1 EP300

9.38e-0413502MM15622
PathwayREACTOME_TRANSCRIPTIONAL_ACTIVATION_OF_MITOCHONDRIAL_BIOGENESIS

NCOA6 NCOA1 CREBBP

9.67e-0455503M27145
PathwayREACTOME_ESR_MEDIATED_SIGNALING

TNRC6A NCOA1 TNRC6C CREBBP EP300

1.06e-03220505M27794
PathwayREACTOME_RUNX3_REGULATES_NOTCH_SIGNALING

CREBBP EP300

1.09e-0314502M27808
PathwayREACTOME_GASTRULATION

TCF7L2 CREBBP EP300 MSGN1

1.11e-03129504M46433
PathwayREACTOME_SIGNALING_BY_NOTCH1_PEST_DOMAIN_MUTANTS_IN_CANCER

HEYL CREBBP EP300

1.13e-0358503M29616
PathwayREACTOME_ADHERENS_JUNCTIONS_INTERACTIONS

HEYL TNRC6A TNRC6C

1.13e-0358503M11980
PathwayREACTOME_CYTOPROTECTION_BY_HMOX1

NCOA6 NCOA1 CREBBP

1.25e-0360503M41830
PathwayBIOCARTA_RELA_PATHWAY

CREBBP EP300

1.26e-0315502MM1339
PathwayBIOCARTA_RELA_PATHWAY

CREBBP EP300

1.26e-0315502M10183
PathwayBIOCARTA_PITX2_PATHWAY

CREBBP EP300

1.26e-0315502MM1439
PathwayREACTOME_TRAF3_DEPENDENT_IRF_ACTIVATION_PATHWAY

CREBBP EP300

1.26e-0315502M953
PathwayREACTOME_TCF_DEPENDENT_SIGNALING_IN_RESPONSE_TO_WNT

KMT2D TCF7L2 CHD8 CREBBP EP300

1.37e-03233505M27099
PathwayREACTOME_CA2_PATHWAY

TCF7L2 TNRC6A TNRC6C

1.37e-0362503M27321
PathwayREACTOME_REGULATION_OF_GENE_EXPRESSION_IN_LATE_STAGE_BRANCHING_MORPHOGENESIS_PANCREATIC_BUD_PRECURSOR_CELLS

CREBBP EP300

1.43e-0316502M27121
PathwayBIOCARTA_IL7_PATHWAY

CREBBP EP300

1.43e-0316502M1296
PathwayBIOCARTA_IL7_PATHWAY

CREBBP EP300

1.43e-0316502MM1420
PathwayBIOCARTA_PITX2_PATHWAY

CREBBP EP300

1.43e-0316502M8516
PathwayREACTOME_FOXO_MEDIATED_TRANSCRIPTION_OF_CELL_DEATH_GENES

CREBBP EP300

1.43e-0316502M27940
PathwayREACTOME_REGULATION_OF_RUNX1_EXPRESSION_AND_ACTIVITY

TNRC6A TNRC6C

1.62e-0317502M27788
PathwayBIOCARTA_TGFB_PATHWAY

CREBBP EP300

1.62e-0317502MM1509
PathwayREACTOME_ZYGOTIC_GENOME_ACTIVATION_ZGA

CREBBP EP300

1.62e-0317502M48025
PathwayPID_HIF1_TFPATHWAY

NCOA1 CREBBP EP300

1.64e-0366503M255
PathwayREACTOME_SIGNALING_BY_NOTCH

HEYL TNRC6A TNRC6C CREBBP EP300

1.74e-03246505M10189
PathwayKEGG_MEDICUS_REFERENCE_GLOBAL_GENOME_NER

GTF2H1 RAD23B

1.82e-0318502M47821
PathwayREACTOME_FORMATION_OF_PARAXIAL_MESODERM

CREBBP EP300 MSGN1

1.87e-0369503M46439
PathwayKEGG_WNT_SIGNALING_PATHWAY

TCF7L2 CHD8 CREBBP EP300

1.99e-03151504M19428
PathwayREACTOME_REGULATION_OF_MITF_M_DEPENDENT_GENES_INVOLVED_IN_APOPTOSIS

TNRC6A TNRC6C

2.03e-0319502M48238
PathwayBIOCARTA_TGFB_PATHWAY

CREBBP EP300

2.03e-0319502M18933
PathwayREACTOME_NFE2L2_REGULATING_ANTI_OXIDANT_DETOXIFICATION_ENZYMES

CREBBP EP300

2.03e-0319502M46442
PathwayREACTOME_METABOLISM_OF_STEROIDS

NCOA6 MBTPS1 NCOA1 CREBBP

2.13e-03154504M27832
PathwayKEGG_ADHERENS_JUNCTION

TCF7L2 CREBBP EP300

2.19e-0373503M638
PathwayREACTOME_NOTCH4_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION

CREBBP EP300

2.25e-0320502M27881
Pubmed

MLL3/MLL4 are required for CBP/p300 binding on enhancers and super-enhancer formation in brown adipogenesis.

KMT2C KMT2D CREBBP EP300

1.04e-11464428398509
Pubmed

Activating signal cointegrator 2 belongs to a novel steady-state complex that contains a subset of trithorax group proteins.

KMT2C NCOA6 KMT2D NCOA1 CREBBP

3.56e-111464512482968
Pubmed

Human transcription factor protein interaction networks.

CYLD KMT2C NCOA6 KMT2D TCF7L2 GLI3 MATR3 TNRC6A NCOA1 GON4L CHD8 TNRC6C ARID1A SS18 CREBBP RCC2 EP300

5.45e-101429641735140242
Pubmed

Comparative Application of BioID and TurboID for Protein-Proximity Biotinylation.

KMT2C NCOA6 KMT2D TCF7L2 ACAT1 MATR3 TNRC6A NUP188 ARID1A CREBBP EP300

7.11e-10457641132344865
Pubmed

Interaction network of human early embryonic transcription factors.

KMT2C NCOA6 KMT2D TCF7L2 EGR2 NCOA1 CHD8 ARID1A CREBBP EP300

9.01e-10351641038297188
Pubmed

PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.

KMT2C NCOA6 KMT2D TCF7L2 ZNF174 NCOA1 RCC1 CHD8 ARID1A CREBBP RCC2 EP300 CSTF2T DDX6 RAD23B

1.12e-091103641534189442
Pubmed

SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.

KMT2C NCOA6 GAPVD1 KMT2D MATR3 RCC1 CHD8 ARID1A CREBBP EP300 CSTF2T

4.80e-09549641138280479
Pubmed

Identification of a transcriptionally active peroxisome proliferator-activated receptor alpha -interacting cofactor complex in rat liver and characterization of PRIC285 as a coactivator.

NCOA6 NCOA1 CREBBP EP300

5.10e-091264412189208
Pubmed

K25 (K25irs1), K26 (K25irs2), K27 (K25irs3), and K28 (K25irs4) represent the type I inner root sheath keratins of the human hair follicle.

KRT26 KRT27 KRT25

5.94e-09364316874310
Pubmed

Agonist-specific Protein Interactomes of Glucocorticoid and Androgen Receptor as Revealed by Proximity Mapping.

NCOA6 KMT2D NCOA1 NUP188 ARID1A RCC2

7.07e-097864628611094
Pubmed

MED25 is distinct from TRAP220/MED1 in cooperating with CBP for retinoid receptor activation.

MED25 NCOA1 CREBBP EP300

1.03e-081464417641689
Pubmed

The Epigenetic Factor Landscape of Developing Neocortex Is Regulated by Transcription Factors Pax6→ Tbr2→ Tbr1.

NCOA6 KMT2D CHD8 ARID1A SS18 CREBBP EP300

1.67e-0815764730186101
Pubmed

Cancer gene mutation frequencies for the U.S. population.

KMT2C KMT2D ARID1A

2.37e-08464334645806
Pubmed

Human immunodeficiency virus type 1 (HIV-1) accessory protein Vpr induces transcription of the HIV-1 and glucocorticoid-responsive promoters by binding directly to p300/CBP coactivators.

NCOA1 CREBBP EP300

2.37e-08464312208951
Pubmed

The oncoprotein Tax binds the SRC-1-interacting domain of CBP/p300 to mediate transcriptional activation.

NCOA1 CREBBP EP300

2.37e-08464311463834
Pubmed

Analysis of the steroid receptor coactivator 1 (SRC1)-CREB binding protein interaction interface and its importance for the function of SRC1.

NCOA1 CREBBP EP300

2.37e-08464311113179
Pubmed

T0070907, a selective ligand for peroxisome proliferator-activated receptor gamma, functions as an antagonist of biochemical and cellular activities.

NCOA6 NCOA1 CREBBP EP300

4.94e-082064411877444
Pubmed

Structural and functional characterization of an atypical activation domain in erythroid Kruppel-like factor (EKLF).

GTF2H1 CREBBP EP300

5.93e-08564321670263
Pubmed

A Conserved alpha-helical motif mediates the binding of diverse nuclear proteins to the SRC1 interaction domain of CBP.

NCOA1 CREBBP EP300

5.93e-08564314722092
Pubmed

Interaction of PIMT with transcriptional coactivators CBP, p300, and PBP differential role in transcriptional regulation.

NCOA6 CREBBP EP300

5.93e-08564311912212
Pubmed

Nuclear receptor-coregulator interaction profiling identifies TRIP3 as a novel peroxisome proliferator-activated receptor gamma cofactor.

NCOA6 NCOA1 CREBBP EP300

6.09e-082164419596656
Pubmed

New nomenclature for chromatin-modifying enzymes.

KMT2C KMT2D NCOA1 CREBBP EP300

7.00e-085764518022353
Pubmed

Temporal/spatial expression of nuclear receptor coactivators in the mouse lung.

NCOA1 CREBBP EP300

1.18e-07664311076796
Pubmed

Role of CBP in regulating HIF-1-mediated activation of transcription.

NCOA1 CREBBP EP300

1.18e-07664315615775
Pubmed

ICAT inhibits beta-catenin binding to Tcf/Lef-family transcription factors and the general coactivator p300 using independent structural modules.

TCF7L2 CREBBP EP300

1.18e-07664312408825
Pubmed

DAF-16 recruits the CREB-binding protein coactivator complex to the insulin-like growth factor binding protein 1 promoter in HepG2 cells.

NCOA1 CREBBP EP300

1.18e-07664310973497
Pubmed

Bcl3, an IkappaB protein, stimulates activating protein-1 transactivation and cellular proliferation.

NCOA1 CREBBP EP300

1.18e-07664310497212
Pubmed

Coactivator as a target gene specificity determinant for histone H3 lysine 4 methyltransferases.

KMT2C NCOA6 KMT2D

1.18e-07664317021013
Pubmed

The RNA binding protein MEX3A promotes tumor progression of breast cancer by post-transcriptional regulation of IGFBP4.

ABL2 PLEKHA2 RCC1 CHD8 ARID1A SS18 CREBBP EP300

1.76e-0733264837433992
Pubmed

Chromatin remodelling by the glucocorticoid receptor requires the BRG1 complex.

NCOA1 CREBBP EP300

2.07e-0776439590696
Pubmed

ASCOM controls farnesoid X receptor transactivation through its associated histone H3 lysine 4 methyltransferase activity.

KMT2C NCOA6 KMT2D

2.07e-07764319556342
Pubmed

A DDX6-CNOT1 complex and W-binding pockets in CNOT9 reveal direct links between miRNA target recognition and silencing.

TNRC6A TNRC6C DDX6

3.31e-07864324768540
Pubmed

Aberrant association of promyelocytic leukemia protein-retinoic acid receptor-alpha with coactivators contributes to its ability to regulate gene expression.

NCOA1 CREBBP EP300

3.31e-07864317475621
Pubmed

ZMYM3 regulates BRCA1 localization at damaged chromatin to promote DNA repair.

MATR3 GON4L RCC1 CHD8 ARID1A RAD23B

3.55e-0715064628242625
Pubmed

Identification of the SOX2 Interactome by BioID Reveals EP300 as a Mediator of SOX2-dependent Squamous Differentiation and Lung Squamous Cell Carcinoma Growth.

NCOA6 KMT2D TCF7L2 ARID1A EP300

4.68e-078364528794006
Pubmed

Identification and functional characterization of transcriptional activators in human cells.

KMT2C KMT2D TCF7L2 NCOA1 GON4L ARID1A CREBBP EP300

6.94e-0739864835016035
Pubmed

Natural helix 9 mutants of PPARγ differently affect its transcriptional activity.

NCOA1 CREBBP EP300

7.07e-071064330595551
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

HEYL KMT2C NCOA6 KMT2D ZNF628 MFN2 CHD8 NUP188 TNRC6C ARID1A D2HGDH EP300

7.14e-071105641235748872
Pubmed

A census of human transcription factors: function, expression and evolution.

HEYL POU6F2 KMT2D TCF7L2 EGR2 ZNF174 GLI3 NCOA1 GON4L RHOXF1 MSGN1

7.61e-07908641119274049
Pubmed

Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity.

GAPVD1 GTF2H1 RPS6KA4 ABL2 RCC1 NUP188 CREBBP RCC2 EP300 DDX6 RAD23B

7.78e-07910641136736316
Pubmed

Activating signal cointegrator 1, a novel transcription coactivator of nuclear receptors, and its cytosolic localization under conditions of serum deprivation.

NCOA1 CREBBP EP300

9.70e-071164310454579
Pubmed

Corepressors selectively control the transcriptional activity of PPARgamma in adipocytes.

NCOA1 CREBBP EP300

9.70e-071164315681609
Pubmed

Enhancer Activity Requires CBP/P300 Bromodomain-Dependent Histone H3K27 Acetylation.

GAPVD1 RCC1 CREBBP RCC2 EP300 DDX6

1.03e-0618064630110629
Pubmed

The human type I keratin gene family: characterization of new hair follicle specific members and evaluation of the chromosome 17q21.2 gene domain.

KRT26 KRT27 KRT25

1.29e-061264315617563
Pubmed

Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

KMT2C GAPVD1 COL20A1 TNRC6A RCC2

1.37e-0610364510819331
Pubmed

Retinoid signaling and neurogenin2 function are coupled for the specification of spinal motor neurons through a chromatin modifier CBP.

EGR2 CREBBP EP300

1.68e-061364319524524
Pubmed

Demethylation of H3K27 regulates polycomb recruitment and H2A ubiquitination.

KMT2C NCOA6 KMT2D

1.68e-061364317761849
Pubmed

The CRL4DCAF6 E3 ligase ubiquitinates CtBP1/2 to induce apoptotic signalling and promote intervertebral disc degeneration.

MFN2 RCC1 CHD8 ARID1A RCC2 EP300

1.85e-0619964636688959
Pubmed

TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.

PLEKHH1 NCOA6 KMT2D NCOA1 ARID1A SS18 CREBBP EP300 RYR2

2.49e-0663864931182584
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

PLEKHH1 EP400P1 KMT2C MBTPS1 POU6F2 TCF7L2 RTEL1 PLEKHA2 IQCN TNRC6C ARID1A CREBBP EP300

2.64e-061489641328611215
Pubmed

A nuclear factor, ASC-2, as a cancer-amplified transcriptional coactivator essential for ligand-dependent transactivation by nuclear receptors in vivo.

NCOA6 NCOA1 CREBBP

2.66e-061564310567404
Pubmed

The BRCT-domain containing protein PTIP links PAX2 to a histone H3, lysine 4 methyltransferase complex.

KMT2C NCOA6 KMT2D

2.66e-061564317925232
Pubmed

SET1 and p300 act synergistically, through coupled histone modifications, in transcriptional activation by p53.

KMT2C NCOA6 EP300

3.27e-061664323870121
Pubmed

A human RNA polymerase II complex containing factors that modify chromatin structure.

GTF2H1 CREBBP EP300

3.27e-06166439710619
Pubmed

H3K4 mono- and di-methyltransferase MLL4 is required for enhancer activation during cell differentiation.

KMT2C NCOA6 KMT2D

3.27e-061664324368734
Pubmed

TRIM33 drives prostate tumor growth by stabilizing androgen receptor from Skp2-mediated degradation.

KMT2C KMT2D MATR3 NCOA1 ARID1A EP300

3.30e-0622064635785414
Pubmed

Loss of p300 accelerates MDS-associated leukemogenesis.

CREBBP EP300

3.33e-06264227881875
Pubmed

Mll3 and Mll4 Facilitate Enhancer RNA Synthesis and Transcription from Promoters Independently of H3K4 Monomethylation.

KMT2C KMT2D

3.33e-06264228483418
Pubmed

Molecular characterization of the histone acetyltransferase CREBBP/EP300 genes in myeloid neoplasia.

CREBBP EP300

3.33e-06264234845315
Pubmed

p300 plays a critical role in maintaining cardiac mitochondrial function and cell survival in postnatal hearts.

CREBBP EP300

3.33e-06264219729597
Pubmed

Endogenous CCAAT/enhancer binding protein beta and p300 are both regulated by growth hormone to mediate transcriptional activation.

CREBBP EP300

3.33e-06264215860545
Pubmed

Further delineation of an entity caused by CREBBP and EP300 mutations but not resembling Rubinstein-Taybi syndrome.

CREBBP EP300

3.33e-06264229460469
Pubmed

Expression of p300 and CBP is associated with poor prognosis in small cell lung cancer.

CREBBP EP300

3.33e-06264224551300
Pubmed

The MLL3/4 H3K4 methyltransferase complex in establishing an active enhancer landscape.

KMT2C KMT2D

3.33e-06264234156443
Pubmed

Genome-wide CRISPR screens reveal synthetic lethal interaction between CREBBP and EP300 in diffuse large B-cell lymphoma.

CREBBP EP300

3.33e-06264233911074
Pubmed

The adenovirus 12 E1A proteins can bind directly to proteins of the p300 transcription co-activator family, including the CREB-binding protein CBP and p300.

CREBBP EP300

3.33e-0626429018065
Pubmed

Coactivators p300 and CBP maintain the identity of mouse embryonic stem cells by mediating long-range chromatin structure.

CREBBP EP300

3.33e-06264224648406
Pubmed

CBP and P300 regulate distinct gene networks required for human primary myoblast differentiation and muscle integrity.

CREBBP EP300

3.33e-06264230135524
Pubmed

CREB-binding protein/P300 bromodomain inhibition reduces neutrophil accumulation and activates antitumor immunity in triple-negative breast cancer.

CREBBP EP300

3.33e-06264239287984
Pubmed

Distribution of co-activators CBP and p300 during mouse oocyte and embryo development.

CREBBP EP300

3.33e-06264216596650
Pubmed

The p300 and CBP Transcriptional Coactivators Are Required for β-Cell and α-Cell Proliferation.

CREBBP EP300

3.33e-06264229217654
Pubmed

Exon deletions of the EP300 and CREBBP genes in two children with Rubinstein-Taybi syndrome detected by aCGH.

CREBBP EP300

3.33e-06264220717166
Pubmed

Differences in the interactions of oncogenic adenovirus 12 early region 1A and nononcogenic adenovirus 2 early region 1A with the cellular coactivators p300 and CBP.

CREBBP EP300

3.33e-06264210049825
Pubmed

CBP/p300 acetyltransferase activity in hematologic malignancies.

CREBBP EP300

3.33e-06264227380996
Pubmed

CREBBP and p300 lysine acetyl transferases in the DNA damage response.

CREBBP EP300

3.33e-06264229170789
Pubmed

The epigenetic regulators CBP and p300 facilitate leukemogenesis and represent therapeutic targets in acute myeloid leukemia.

CREBBP EP300

3.33e-06264225893291
Pubmed

Human T-lymphotropic virus type 1 p30(II) regulates gene transcription by binding CREB binding protein/p300.

CREBBP EP300

3.33e-06264211559821
Pubmed

Crebbp haploinsufficiency in mice alters the bone marrow microenvironment, leading to loss of stem cells and excessive myelopoiesis.

CREBBP EP300

3.33e-06264221555743
Pubmed

TCF-4 binds beta-catenin and is expressed in distinct regions of the embryonic brain and limbs.

TCF7L2 EGR2

3.33e-0626429784592
Pubmed

CBP/p300 induction is required for retinoic acid sensitivity in human mammary cells.

CREBBP EP300

3.33e-06264212646247
Pubmed

KMT2C/D COMPASS complex-associated diseases [KCDCOM-ADs]: an emerging class of congenital regulopathies.

KMT2C KMT2D

3.33e-06264231924266
Pubmed

CARM1 inhibition reduces histone acetyltransferase activity causing synthetic lethality in CREBBP/EP300-mutated lymphomas.

CREBBP EP300

3.33e-06264232576962
Pubmed

Reduced Expression of Histone Methyltransferases KMT2C and KMT2D Correlates with Improved Outcome in Pancreatic Ductal Adenocarcinoma.

KMT2C KMT2D

3.33e-06264227280393
Pubmed

Syndromic features and mild cognitive impairment in mice with genetic reduction on p300 activity: Differential contribution of p300 and CBP to Rubinstein-Taybi syndrome etiology.

CREBBP EP300

3.33e-06264219822209
Pubmed

A specific CBP/p300-dependent gene expression programme drives the metabolic remodelling in late stages of spermatogenesis.

CREBBP EP300

3.33e-06264224522976
Pubmed

RNA helicase DDX6 and scaffold protein GW182 in P-bodies promote biogenesis of stress granules.

TNRC6A DDX6

3.33e-06264237427791
Pubmed

Histone acetyltransferase activities of cAMP-regulated enhancer-binding protein and p300 in tissues of fetal, young, and old mice.

CREBBP EP300

3.33e-06264211867645
Pubmed

CBP is required for environmental enrichment-induced neurogenesis and cognitive enhancement.

CREBBP EP300

3.33e-06264221847097
Pubmed

Expression of the nuclear coactivators CBP and p300 in developing craniofacial tissue.

CREBBP EP300

3.33e-06264211963968
Pubmed

p300 or CBP is required for insulin-stimulated glucose uptake in skeletal muscle and adipocytes.

CREBBP EP300

3.33e-06264234813504
Pubmed

Loss of MLL3/4 decouples enhancer H3K4 monomethylation, H3K27 acetylation, and gene activation during embryonic stem cell differentiation.

KMT2C KMT2D

3.33e-06264236869380
Pubmed

Differential transcriptional activation by human T-cell leukemia virus type 1 Tax mutants is mediated by distinct interactions with CREB binding protein and p300.

CREBBP EP300

3.33e-0626429528808
Pubmed

Analysis of genetic stability at the EP300 and CREBBP loci in a panel of cancer cell lines.

CREBBP EP300

3.33e-06264212696060
Pubmed

p300 interacts with the nuclear proto-oncoprotein SYT as part of the active control of cell adhesion.

SS18 EP300

3.33e-06264211030627
Pubmed

Rubinstein-Taybi Syndrome

CREBBP EP300

3.33e-06264220301699
Pubmed

Histone H3K4 monomethylation catalyzed by Trr and mammalian COMPASS-like proteins at enhancers is dispensable for development and viability.

KMT2C KMT2D

3.33e-06264228967912
Pubmed

CBP Is Required for Establishing Adaptive Gene Programs in the Adult Mouse Brain.

CREBBP EP300

3.33e-06264236109165
Pubmed

Potential biomarker of metformin action.

CREBBP EP300

3.33e-06264224639469
Pubmed

The histone acetyl transferases CBP and p300 regulate stress response pathways in synovial fibroblasts at transcriptional and functional levels.

CREBBP EP300

3.33e-06264237816914
Pubmed

Retinoids and retinoic acid receptors regulate growth arrest and apoptosis in human mammary epithelial cells and modulate expression of CBP/p300.

CREBBP EP300

3.33e-06264212242694
InteractionERG interactions

KMT2C NCOA6 KMT2D TCF7L2 MATR3 ARID1A SS18 CREBBP RCC2 EP300

1.72e-092236310int:ERG
InteractionGCM1 interactions

KMT2C KMT2D TCF7L2 ARID1A SS18 CREBBP EP300

1.73e-0968637int:GCM1
InteractionTBXT interactions

KMT2C NCOA6 KMT2D TCF7L2 ARID1A SS18 CREBBP EP300

2.81e-09116638int:TBXT
InteractionEGR2 interactions

KMT2C NCOA6 KMT2D TCF7L2 EGR2 NCOA1 ARID1A CREBBP EP300

2.95e-09171639int:EGR2
InteractionFOS interactions

CYLD KMT2C NCOA6 KMT2D TCF7L2 RPS6KA4 NCOA1 ARID1A SS18 CREBBP EP300

3.09e-093126311int:FOS
InteractionSOX7 interactions

KMT2C KMT2D TCF7L2 NCOA1 ARID1A CREBBP EP300

6.55e-0982637int:SOX7
InteractionHNF4A interactions

KMT2C NCOA6 GTF2H1 KMT2D TCF7L2 NCOA1 ARID1A SS18 CREBBP EP300

1.29e-082756310int:HNF4A
InteractionFOXI1 interactions

KMT2C KMT2D TCF7L2 ARID1A CREBBP EP300 CSTF2T

1.47e-0892637int:FOXI1
InteractionNCOA6 interactions

KMT2C NCOA6 KMT2D EGR2 TNRC6A NCOA1 CREBBP EP300

1.64e-08145638int:NCOA6
InteractionNUP35 interactions

KMT2C NCOA6 KMT2D TCF7L2 ACAT1 MATR3 TNRC6A NUP188 ARID1A CREBBP EP300

7.24e-084246311int:NUP35
InteractionPAX7 interactions

KMT2C KMT2D TCF7L2 ARID1A SS18 CREBBP EP300

1.17e-07124637int:PAX7
InteractionMYOD1 interactions

KMT2C KMT2D TCF7L2 NCOA1 ARID1A SS18 CREBBP EP300

1.57e-07194638int:MYOD1
InteractionKLF5 interactions

KMT2C NCOA6 KMT2D TCF7L2 ARID1A SS18 CREBBP EP300

1.63e-07195638int:KLF5
InteractionHNF1A interactions

KMT2C KMT2D TCF7L2 NCOA1 CREBBP EP300

1.83e-0780636int:HNF1A
InteractionGATA2 interactions

KMT2C NCOA6 KMT2D TCF7L2 ARID1A SS18 CREBBP EP300

1.91e-07199638int:GATA2
InteractionRBBP5 interactions

KMT2C NCOA6 KMT2D EGR2 TNRC6A CHD8 ARID1A CREBBP EP300

2.57e-07287639int:RBBP5
InteractionAR interactions

KMT2C NCOA6 GTF2H1 KMT2D TCF7L2 ABL2 GLI3 MATR3 NCOA1 CHD8 NUP188 ARID1A CREBBP RCC2 EP300

2.88e-079926315int:AR
InteractionTLX3 interactions

KMT2C NCOA6 POU6F2 GTF2H1 KMT2D TCF7L2 ZNF41 ARID1A EP300

2.88e-07291639int:TLX3
InteractionSP7 interactions

KMT2C NCOA6 KMT2D TCF7L2 NCOA1 ARID1A SS18 CREBBP EP300

4.16e-07304639int:SP7
InteractionPAGR1 interactions

KMT2C NCOA6 KMT2D EGR2 NCOA1

5.34e-0751635int:PAGR1
InteractionSOX9 interactions

KMT2C NCOA6 KMT2D ARID1A CREBBP EP300

5.79e-0797636int:SOX9
InteractionSMG7 interactions

NCOA6 KMT2D TNRC6A NCOA1 CHD8 TNRC6C ARID1A CREBBP DDX6

6.23e-07319639int:SMG7
InteractionTPRX2 interactions

NCOA6 KMT2D CHD8 ARID1A CREBBP

8.58e-0756635int:TPRX2
InteractionNR6A1 interactions

TCF7L2 NCOA1 CREBBP EP300

8.79e-0724634int:NR6A1
InteractionCEBPA interactions

KMT2C NCOA6 KMT2D TCF7L2 ZNF174 MATR3 NCOA1 RCC1 CHD8 ARID1A CREBBP RCC2 EP300 CSTF2T DDX6 RAD23B

9.45e-0712456316int:CEBPA
InteractionHDAC1 interactions

MBTPS1 GAPVD1 KMT2D TCF7L2 GLI3 MATR3 TNRC6A GON4L CHD8 HSD17B10 ARID1A SS18 CREBBP EP300 CSTF2T

1.17e-0611086315int:HDAC1
InteractionTEAD1 interactions

KMT2C KMT2D TCF7L2 NCOA1 ARID1A CREBBP EP300

1.26e-06176637int:TEAD1
InteractionASH2L interactions

KMT2C NCOA6 KMT2D TNRC6A CHD8 RCC2 EP300 RAD23B

1.67e-06265638int:ASH2L
InteractionHNF1B interactions

KMT2C POU6F2 KMT2D TCF7L2 ARID1A CREBBP EP300

2.10e-06190637int:HNF1B
InteractionETV4 interactions

KMT2D ARID1A SS18 CREBBP EP300

2.45e-0669635int:ETV4
InteractionTNRC6A interactions

CYLD KMT2C NCOA6 GLI3 TNRC6A TNRC6C ARID1A DDX6

2.51e-06280638int:TNRC6A
InteractionFEV interactions

KMT2C NCOA6 KMT2D TCF7L2 ARID1A CREBBP EP300

3.26e-06203637int:FEV
InteractionH2AC4 interactions

KMT2C KMT2D GON4L RCC1 CHD8 HSD17B10 ARID1A CREBBP EP300 RAD23B

3.53e-065066310int:H2AC4
InteractionCNOT3 interactions

GLI3 ACBD5 TNRC6A TNRC6C CREBBP EP300 DDX6

3.70e-06207637int:CNOT3
InteractionE2F5 interactions

KMT2D ARID1A CREBBP EP300

4.74e-0636634int:E2F5
InteractionHOXB2 interactions

KMT2D NCOA1 CREBBP EP300

4.74e-0636634int:HOXB2
InteractionKLF1 interactions

GTF2H1 ARID1A CREBBP EP300

5.30e-0637634int:KLF1
InteractionYTHDF2 interactions

CYLD GLI3 ACBD5 TNRC6A TNRC6C ZCCHC2 CREBBP DDX6

5.58e-06312638int:YTHDF2
InteractionWDR5 interactions

CYLD KMT2C NCOA6 KMT2D ACAT1 EGR2 MATR3 TNRC6A RCC1 CHD8 CREBBP RCC2 EP300 DDX6

5.87e-0611016314int:WDR5
InteractionWWTR1 interactions

NCOA6 GAPVD1 KMT2D RCC1 CHD8 ARID1A CREBBP EP300 CSTF2T

6.19e-06422639int:WWTR1
InteractionNCOA1 interactions

NCOA6 EGR2 NCOA1 ARID1A CREBBP EP300

6.31e-06146636int:NCOA1
InteractionELF5 interactions

KMT2C KMT2D MATR3 ARID1A SS18 EP300

6.56e-06147636int:ELF5
InteractionIRF4 interactions

KMT2C KMT2D ARID1A SS18 EP300

6.87e-0685635int:IRF4
InteractionGSC interactions

KMT2C KMT2D TCF7L2 CREBBP EP300

7.70e-0687635int:GSC
InteractionASCL2 interactions

KMT2C NCOA6 EP300

8.14e-0613633int:ASCL2
InteractionKRT71 interactions

CYLD KRT26 KRT27 KRT25

9.76e-0643634int:KRT71
InteractionSMAD3 interactions

CYLD HEYL NCOA6 GLI3 NCOA1 CHD8 ARID1A CREBBP EP300

9.82e-06447639int:SMAD3
InteractionSOX10 interactions

POU6F2 KMT2D EGR2 ARID1A EP300

1.01e-0592635int:SOX10
InteractionSMAD1 interactions

NCOA6 KMT2D GLI3 MED25 ARID1A CREBBP EP300

1.06e-05243637int:SMAD1
InteractionSOX17 interactions

KMT2C NCOA6 KMT2D ARID1A SS18

1.19e-0595635int:SOX17
InteractionSS18L1 interactions

EGR2 ARID1A SS18 CREBBP EP300

1.38e-0598635int:SS18L1
InteractionCRX interactions

KMT2C KMT2D TCF7L2 NCOA1 ARID1A CREBBP EP300

1.41e-05254637int:CRX
InteractionRXRA interactions

NCOA6 MATR3 MED25 NCOA1 CREBBP EP300

1.46e-05169636int:RXRA
InteractionKMT2D interactions

KMT2C NCOA6 KMT2D EGR2 CREBBP EP300

1.46e-05169636int:KMT2D
InteractionSETD1A interactions

KMT2C NCOA6 KMT2D CHD8 CREBBP EP300

1.51e-05170636int:SETD1A
InteractionCREBBP interactions

NCOA6 KMT2D TCF7L2 EGR2 GLI3 MED25 NCOA1 ARID1A CREBBP EP300

1.54e-055996310int:CREBBP
InteractionTLX1 interactions

KMT2C KMT2D TCF7L2 ARID1A CREBBP EP300

1.77e-05175636int:TLX1
InteractionEP300 interactions

NCOA6 GAPVD1 KMT2D TCF7L2 EGR2 HDHD5 MATR3 NCOA1 RCC1 ARID1A SS18 CREBBP RCC2 EP300 DDX6

2.02e-0514016315int:EP300
InteractionTLE3 interactions

KMT2D TCF7L2 EGR2 TNRC6A NCOA1 ARID1A CREBBP EP300

2.16e-05376638int:TLE3
InteractionARID1A interactions

EGR2 TNRC6A NCOA1 ARID1A SS18 CREBBP EP300

2.41e-05276637int:ARID1A
InteractionMEX3A interactions

ABL2 PLEKHA2 RCC1 CHD8 ARID1A SS18 CREBBP EP300

2.51e-05384638int:MEX3A
InteractionPAX8 interactions

KMT2C KMT2D ARID1A CREBBP EP300

2.52e-05111635int:PAX8
InteractionTHRA interactions

NCOA6 MED25 NCOA1 CREBBP EP300

2.52e-05111635int:THRA
InteractionSMAD2 interactions

KMT2C NCOA6 ZNF41 GLI3 MED25 ARID1A CREBBP EP300

2.55e-05385638int:SMAD2
InteractionNFIA interactions

KMT2D TCF7L2 EGR2 ARID1A CREBBP EP300

2.66e-05188636int:NFIA
InteractionTBR1 interactions

KMT2C KMT2D TCF7L2 ARID1A EP300

2.75e-05113635int:TBR1
InteractionYAP1 interactions

KMT2C NCOA6 GAPVD1 KMT2D MATR3 RCC1 CHD8 ARID1A CREBBP KRT25 EP300 CSTF2T DDX6

2.77e-0510956313int:YAP1
InteractionBCL3 interactions

CYLD NCOA1 CREBBP EP300

2.82e-0556634int:BCL3
InteractionPSMC2 interactions

CYLD GAPVD1 GTF2H1 ACBD5 MFN2 EP300 DDX6 RAD23B

2.96e-05393638int:PSMC2
InteractionTRIM24 interactions

EGR2 MATR3 TNRC6A NCOA1 TNRC6C CREBBP EP300 DDX6

3.23e-05398638int:TRIM24
InteractionRARG interactions

TCF7L2 NCOA1 ARID1A EP300

3.24e-0558634int:RARG
InteractionKRT72 interactions

CYLD KRT26 KRT27 KRT25

3.47e-0559634int:KRT72
InteractionHCFC1 interactions

KMT2C NCOA6 KMT2D EGR2 MED25 CHD8 DDX6

3.52e-05293637int:HCFC1
InteractionTOP3B interactions

HEYL KMT2C NCOA6 KMT2D ZNF628 RTEL1 MFN2 RCC1 CHD8 NUP188 TNRC6C ARID1A D2HGDH EP300 DDX6

3.55e-0514706315int:TOP3B
InteractionH2BC3 interactions

CYLD KMT2C KMT2D GON4L CHD8 CREBBP EP300 RAD23B

3.72e-05406638int:H2BC3
InteractionETS1 interactions

KMT2D NCOA1 ARID1A CREBBP EP300

3.82e-05121635int:ETS1
InteractionNR3C1 interactions

PLEKHH1 NCOA6 GAPVD1 KMT2D MED25 NCOA1 NUP188 ARID1A SS18 CREBBP EP300 RYR2

4.14e-059746312int:NR3C1
InteractionKRT4 interactions

CYLD KRT26 KRT27 KRT25

4.22e-0562634int:KRT4
InteractionDEAF1 interactions

TCF7L2 CREBBP EP300 RAD23B

4.79e-0564634int:DEAF1
InteractionUTY interactions

KMT2C NCOA6 KMT2D

4.93e-0523633int:UTY
InteractionPAN3 interactions

TNRC6A TNRC6C D2HGDH DDX6

5.09e-0565634int:PAN3
InteractionPAX9 interactions

KMT2C NCOA6 KMT2D ARID1A EP300

5.38e-05130635int:PAX9
InteractionKMT2B interactions

KMT2C NCOA6 KMT2D TNRC6A RCC1

5.38e-05130635int:KMT2B
InteractionKMT2C interactions

KMT2C NCOA6 KMT2D EGR2 TNRC6A

6.22e-05134635int:KMT2C
InteractionRARA interactions

NCOA6 MED25 NCOA1 ARID1A CREBBP EP300

6.89e-05223636int:RARA
InteractionRAD23A interactions

GTF2H1 COL20A1 ACBD5 CREBBP EP300 RAD23B

7.06e-05224636int:RAD23A
InteractionNCOA2 interactions

NCOA6 EGR2 NCOA1 CREBBP EP300

7.92e-05141635int:NCOA2
InteractionGPBP1 interactions

TNRC6A TNRC6C CREBBP EP300

8.92e-0575634int:GPBP1
InteractionPSMC6 interactions

CYLD GAPVD1 MATR3 MFN2 HSD17B10 RCC2 RAD23B

9.33e-05342637int:PSMC6
InteractionTCF12 interactions

TCF7L2 CREBBP EP300 DDX6 MSGN1

9.96e-05148635int:TCF12
InteractionSOX2 interactions

KMT2C NCOA6 KMT2D TCF7L2 ACAT1 GLI3 MATR3 TNRC6A CHD8 HSD17B10 ARID1A SS18 EP300 RAD23B

1.00e-0414226314int:SOX2
InteractionTOMM20 interactions

CYLD GLI3 ACBD5 TNRC6A HSD17B10 TNRC6C

1.03e-04240636int:TOMM20
InteractionEIF3D interactions

CYLD MATR3 HSD17B10 CREBBP EP300 DDX6

1.13e-04244636int:EIF3D
InteractionASF1A interactions

NCOA6 KMT2D ZNF174 CHD8 ARID1A EP300

1.26e-04249636int:ASF1A
InteractionPPARGC1A interactions

NCOA6 NCOA1 CREBBP EP300

1.26e-0482634int:PPARGC1A
InteractionIRF1 interactions

ARID1A SS18 CREBBP EP300

1.32e-0483634int:IRF1
InteractionNR1H4 interactions

NCOA6 NCOA1 EP300

1.35e-0432633int:NR1H4
InteractionPAX6 interactions

KMT2C NCOA6 KMT2D TCF7L2 ARID1A CREBBP EP300

1.42e-04366637int:PAX6
InteractionLGR6 interactions

TCF7L2 EP300

1.43e-046632int:LGR6
InteractionKLF4 interactions

KMT2C KMT2D ARID1A CREBBP EP300

1.44e-04160635int:KLF4
Cytoband17q21.2

KRT26 KRT27 KRT25 KCNH4

2.94e-067064417q21.2
CytobandEnsembl 112 genes in cytogenetic band chr16q24

MBTPS1 LINC00304 MEAK7

9.28e-04136643chr16q24
GeneFamilyZinc fingers ZZ-type|Lysine acetyltransferases

NCOA1 CREBBP EP300

8.33e-0617433486
GeneFamilyAtaxins|Trinucleotide repeat containing

KMT2D TNRC6A TNRC6C

2.78e-0525433775
GeneFamilyKeratins, type I

KRT26 KRT27 KRT25

3.94e-0528433608
GeneFamilyZinc fingers ZZ-type|Lysine acetyltransferases

CREBBP EP300

8.25e-041843291
GeneFamilyEF-hand domain containing|Nucleotide excision repair|Transcription and export complex 2

GTF2H1 RAD23B

8.25e-04184321269
GeneFamilyZinc fingers C2H2-type|Lysine methyltransferases|PR/SET domain family

KMT2C KMT2D

2.95e-0334432487
GeneFamilyCollagens

COL9A2 COL20A1

5.35e-0346432490
GeneFamilyX-linked mental retardation|Angiotensin receptors

ZNF41 HSD17B10

7.05e-0353432103
ToppCellCV-Mild-6|Mild / Virus stimulation, Condition and Cluster

TCF7L2 EGR2 CHD8 CREBBP RAD23B

5.32e-06175645c4d530dbb37942427c9cd0a1533faeb6a3a45381
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c01-LEF1|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)

BEX3 TNRC6A SORCS3 TNRC6C DDX6

6.79e-061846455350b58aa9979631228835d11eb45ddf81d08bff
DrugGSK-3 Inhibitor IX; Down 200; 0.5uM; PC3; HT_HG-U133A

CYLD ZNF174 MATR3 RCC1 ZCCHC2 MEAK7 CSTF2T RAD23B

6.53e-081926487106_DN
DrugFlumethasone [2135-17-3]; Down 200; 9.8uM; MCF7; HT_HG-U133A

COL9A2 ZNF174 NCOA1 SS18 MEAK7 CSTF2T DDX6 WDR47

8.61e-081996483410_DN
DrugEstradiol-17 beta [50-28-2]; Down 200; 14.6uM; MCF7; HT_HG-U133A

TCF7L2 ZNF174 NCOA1 RCC1 SS18 EP300 DDX6

1.25e-061956475318_DN
DrugChloramphenicol [56-75-7]; Down 200; 12.4uM; HL60; HT_HG-U133A

CYLD MBTPS1 TCF7L2 RPS6KA4 RCC1 CSTF2T RAD23B

1.25e-061956471837_DN
DrugHydrastinine hydrochloride [4884-68-8]; Up 200; 16.4uM; PC3; HT_HG-U133A

CYLD TCF7L2 MED25 RCC1 GLB1L2 DDX6 RAD23B

1.34e-061976472119_UP
DrugClidinium bromide [3485-62-9]; Down 200; 9.2uM; PC3; HT_HG-U133A

CYLD CD101 MED25 MFN2 RCC1 CSTF2T RAD23B

1.34e-061976474499_DN
DrugNalbuphine hydrochloride [23277-43-2]; Up 200; 10.2uM; PC3; HT_HG-U133A

POU6F2 ZNF174 CD101 RCC1 ARID1A DDX6 RAD23B

1.43e-061996475820_UP
DrugPhenoxybenzamine hydrochloride [63-92-3]; Down 200; 11.8uM; PC3; HT_HG-U133A

TCF7L2 GLI3 NCOA1 RCC1 SS18 CSTF2T

1.05e-051776464652_DN
DrugCamptothecine (S,+) [7689-03-4]; Down 200; 11.4uM; PC3; HT_HG-U133A

TCF7L2 GLI3 ARID1A CREBBP EP300 WDR47

1.15e-051806464541_DN
DrugTolbutamide [64-77-7]; Down 200; 14.8uM; MCF7; HT_HG-U133A

TCF7L2 ZNF174 PLEKHA2 RCC1 ARID1A RAD23B

1.57e-051906464362_DN
DrugEstrone [53-16-7]; Down 200; 14.8uM; PC3; HT_HG-U133A

CYLD ZNF174 RCC1 ARID1A CSTF2T RAD23B

1.76e-051946466647_DN
DrugOxybutynin chloride [1508-65-2]; Down 200; 10.2uM; MCF7; HT_HG-U133A

TCF7L2 ZNF174 MED25 MFN2 RCC1 CSTF2T

1.76e-051946463168_DN
DrugSulfamethazine sodium salt [1981-58-4]; Down 200; 13.4uM; MCF7; HT_HG-U133A

CYLD ZNF174 NCOA1 RCC1 SS18 CSTF2T

1.87e-051966463422_DN
DrugNomifensine maleate [32795-47-4]; Down 200; 11.2uM; PC3; HT_HG-U133A

MED25 PLEKHA2 RCC1 CSTF2T DDX6 RAD23B

1.87e-051966465863_DN
DrugFluvastatin sodium salt [93957-55-2]; Down 200; 9.2uM; MCF7; HT_HG-U133A

TCF7L2 GLI3 RCC1 SS18 CSTF2T RAD23B

1.87e-051966465290_DN
DrugBenserazide hydrochloride [14919-77-8]; Down 200; 13.6uM; MCF7; HT_HG-U133A

NCOA1 RCC1 GLB1L2 ZCCHC2 ARID1A RAD23B

1.92e-051976465322_DN
DrugChloroquine diphosphate [50-63-5]; Up 200; 7.8uM; MCF7; HT_HG-U133A

CYLD RCC1 ARID1A CREBBP CSTF2T RYR2

1.92e-051976462869_UP
Drug4,4'-DBP

TCF7L2 CREBBP EP300

1.99e-0519643CID000007034
DrugDicloxacillin sodium salt [13412-64-1]; Down 200; 8.2uM; MCF7; HT_HG-U133A

TCF7L2 RTEL1 NCOA1 GON4L RCC1 RAD23B

2.03e-051996463307_DN
DrugSulpiride [15676-16-1]; Down 200; 11.8uM; MCF7; HT_HG-U133A

TCF7L2 RTEL1 MFN2 SS18 CSTF2T DDX6

2.03e-051996461467_DN
Drugclozapine; Down 200; 10uM; MCF7; HT_HG-U133A

TCF7L2 ZNF174 NCOA1 GLB1L2 CSTF2T DDX6

2.09e-052006466947_DN
Drug3,4-dimethoxy-N-((2,2-dimethyl-2H-chromen-6-yl)methyl)-N-phenylbenzenesulfonamide

CREBBP EP300

7.74e-055642ctd:C575894
Drug2,4-xylidinothiazoline

NCOA6 GLI3 RYR2

8.15e-0530643CID000099296
Drug2-methylacetoacetate

ACAT1 HSD17B10

1.16e-046642CID000150996
Drugandrostan-3-ol

NCOA6 NCOA1

1.16e-046642ctd:C000658
DrugAC1L1COZ

ACAT1 NCOA1 CREBBP EP300

1.21e-0490644CID000001996
DrugTrichostatin A, Streptomyces sp.; Down 200; 1uM; MCF7; HT_HG-U133A

NCOA6 RCC1 ARID1A CREBBP EP300

1.30e-041746451659_DN
DrugTrichostatin A, from Streptomyces sp.; Down 200; 0.1uM; MCF7; HT_HG-U133A

RCC1 ARID1A CREBBP EP300 CSTF2T

1.41e-041776453227_DN
DrugPrenylamine lactate [69-43-2]; Up 200; 9.6uM; HL60; HG-U133A

CYLD TCF7L2 ABL2 CD101 GON4L

1.69e-041846451737_UP
DrugMonensin sodium salt [22373-78-0]; Up 200; 5.8uM; PC3; HT_HG-U133A

CYLD MBTPS1 ABL2 ARID1A RYR2

1.74e-041856457402_UP
Drug2-propylpentanoic acid; Down 200; 50uM; MCF7; HT_HG-U133A

MBTPS1 TCF7L2 RCC1 ARID1A SS18

2.06e-041926451647_DN
DrugZaprinast [37762-06-4]; Down 200; 14.8uM; PC3; HT_HG-U133A

RAG2 MED25 MFN2 ARID1A SS18

2.11e-041936456749_DN
Drugthioridazine hydrochloride; Up 200; 10uM; HL60; HT_HG-U133A

CYLD RTEL1 MED25 ARID1A MEAK7

2.11e-041936456189_UP
DrugPramoxine hydrochloride [637-58-1]; Up 200; 12.2uM; PC3; HT_HG-U133A

MED25 RCC1 CREBBP CSTF2T RAD23B

2.11e-041936453811_UP
DrugPiperine [94-62-2]; Down 200; 14uM; MCF7; HT_HG-U133A

TCF7L2 RTEL1 NCOA1 GON4L DDX6

2.11e-041936453263_DN
DrugFlucytosine [2022-85-7]; Down 200; 31uM; MCF7; HT_HG-U133A

GLI3 RCC1 GLB1L2 SS18 CSTF2T

2.11e-041936455289_DN
DrugGlycocholic acid [475-31-0]; Down 200; 8.6uM; MCF7; HT_HG-U133A

TCF7L2 RCC1 CSTF2T DDX6 RAD23B

2.16e-041946455316_DN
DrugMetergoline [17692-51-2]; Up 200; 10uM; HL60; HG-U133A

CYLD TCF7L2 RTEL1 RCC1 CSTF2T

2.16e-041946451606_UP
DrugThonzonium bromide [553-08-2]; Down 200; 6.8uM; PC3; HT_HG-U133A

MBTPS1 RTEL1 RCC1 CSTF2T RAD23B

2.16e-041946454617_DN
DrugIndomethacin [53-86-1]; Down 200; 11.2uM; PC3; HT_HG-U133A

ZNF174 GON4L ARID1A SS18 CSTF2T

2.16e-041946455049_DN
DrugConessine [546-06-5]; Down 200; 11.2uM; MCF7; HT_HG-U133A

ZNF174 RCC1 GLB1L2 ARID1A SS18

2.16e-041946452792_DN
DrugHarmol hydrochloride monohydrate [40580-83-4]; Down 200; 15.8uM; MCF7; HT_HG-U133A

TCF7L2 RTEL1 ZNF174 NCOA1 PLEKHA2

2.16e-041946452900_DN
DrugFenspiride hydrochloride [5053-08-7]; Down 200; 13.4uM; PC3; HT_HG-U133A

ZNF174 MATR3 RCC1 SS18 RAD23B

2.16e-041946452106_DN
Drug0316684-0000 [391209-55-5]; Down 200; 10uM; PC3; HT_HG-U133A

TCF7L2 MED25 RCC1 CSTF2T RAD23B

2.16e-041946457098_DN
DrugMedrysone [2668-66-8]; Down 200; 11.6uM; MCF7; HT_HG-U133A

TCF7L2 PLEKHA2 RCC1 RYR2 RAD23B

2.16e-041946454727_DN
DrugHalcinonide [3093-35-4]; Down 200; 8.8uM; HL60; HT_HG-U133A

COL9A2 TCF7L2 RTEL1 ZNF174 SS18

2.16e-041946452185_DN
DrugHydrocortisone base [50-23-7]; Up 200; 11uM; MCF7; HT_HG-U133A

CYLD ABL2 MED25 NUP188 SS18

2.16e-041946453284_UP
DrugRolipram [61413-54-5]; Down 200; 14.6uM; MCF7; HT_HG-U133A

RPS6KA4 RCC1 SS18 EP300 RAD23B

2.16e-041946455330_DN
DrugMephenytoin [50-12-4]; Down 200; 18.4uM; MCF7; HT_HG-U133A

CYLD RTEL1 ZNF174 GON4L RYR2

2.22e-041956453580_DN
Drug5279552; Down 200; 22uM; MCF7; HT_HG-U133A_EA

CYLD RPS6KA4 ZNF174 CREBBP EP300

2.22e-04195645843_DN
DrugPentamidine isethionate [140-64-7]; Down 200; 6.8uM; MCF7; HT_HG-U133A

ABL2 RCC1 NUP188 ARID1A CSTF2T

2.22e-041956454396_DN
DrugAtropine sulfate monohydrate [5908-99-6]; Down 200; 5.8uM; MCF7; HT_HG-U133A

ZNF174 NCOA1 RCC1 GLB1L2 ARID1A

2.22e-041956452761_DN
DrugGlibenclamide [10238-21-8]; Down 200; 8uM; MCF7; HT_HG-U133A

TCF7L2 GLI3 MED25 RCC1 DDX6

2.22e-041956453163_DN
DrugPhenazopyridine hydrochloride [136-40-3]; Down 200; 16uM; MCF7; HT_HG-U133A

TCF7L2 GLI3 MFN2 NCOA1 RCC1

2.22e-041956456234_DN
DrugFlupentixol dihydrochloride cis-(Z) [2413-38-9]; Down 200; 7.8uM; MCF7; HT_HG-U133A

RCC1 SS18 CSTF2T DDX6 RAD23B

2.22e-041956455307_DN
DrugIproniazide phosphate [305-33-9]; Down 200; 14.4uM; PC3; HT_HG-U133A

TCF7L2 MED25 GON4L RCC1 RYR2

2.22e-041956452125_DN
DrugAmethopterin (R,S) [59-05-2]; Down 200; 8.8uM; PC3; HT_HG-U133A

RCC1 SS18 CSTF2T RYR2 RAD23B

2.22e-041956456654_DN
Drugprostaglandin E2; Down 200; 10uM; MCF7; HT_HG-U133A

CYLD TCF7L2 MFN2 RCC1 RAD23B

2.22e-041956456552_DN
DrugHydroquinine hydrobromide hydrate [304695-81-6]; Up 200; 9.4uM; MCF7; HT_HG-U133A

CYLD RCC1 ARID1A CSTF2T RAD23B

2.22e-041956452767_UP
DrugRamipril [87333-19-5]; Up 200; 9.6uM; PC3; HT_HG-U133A

MFN2 RCC1 CSTF2T DDX6 RAD23B

2.22e-041956457144_UP
DrugDiperodon hydrochloride [537-12-2]; Up 200; 9.2uM; HL60; HG-U133A

CYLD GLI3 RCC1 ARID1A EP300

2.22e-041956451575_UP
DrugVidarabine [5536-17-4]; Down 200; 15uM; PC3; HT_HG-U133A

TCF7L2 ZNF174 MED25 CHD8 RAD23B

2.22e-041956455850_DN
DrugButylparaben [94-26-8]; Down 200; 20.6uM; MCF7; HT_HG-U133A

TCF7L2 ZNF174 GLI3 CSTF2T DDX6

2.22e-041956455245_DN
DrugCP-645525-01 [287190-82-3]; Down 200; 10uM; PC3; HT_HG-U133A

CYLD MED25 RCC1 CSTF2T WDR47

2.27e-041966457527_DN
DrugMetanephrine hydrochloride DL [881-95-8]; Up 200; 17.2uM; HL60; HG-U133A

CYLD RCC1 EP300 DDX6 RAD23B

2.27e-041966452015_UP
DrugBetulinic acid [472-15-1]; Down 200; 8.8uM; PC3; HT_HG-U133A

ZNF174 MFN2 RCC1 CSTF2T RAD23B

2.27e-041966454101_DN
DrugNorfloxacin [70458-96-7]; Down 200; 12.6uM; PC3; HT_HG-U133A

ZNF174 GON4L RCC1 SS18 RAD23B

2.27e-041966452090_DN
DrugEnoxacin [74011-58-8]; Down 200; 12.4uM; PC3; HT_HG-U133A

TCF7L2 ZNF174 MED25 RCC1 RAD23B

2.27e-041966454655_DN
DrugCanrenoic acid potassium salt [2181-04-6]; Down 200; 10uM; PC3; HT_HG-U133A

TCF7L2 MED25 RCC1 EP300 RAD23B

2.27e-041966452065_DN
DrugRibostamycin sulfate salt [53797-35-6]; Down 200; 7.2uM; PC3; HT_HG-U133A

TCF7L2 RPS6KA4 EP300 CSTF2T RAD23B

2.27e-041966457123_DN
Drugaspirin, USP; Down 200; 100uM; HL60; HT_HG-U133A

TCF7L2 ZNF174 NCOA1 RCC1 SS18

2.32e-041976451145_DN
DrugMephenytoin [50-12-4]; Down 200; 18.4uM; MCF7; HT_HG-U133A

COL9A2 TCF7L2 RPS6KA4 MFN2 SS18

2.32e-041976456275_DN
DrugSerotonin hydrochloride [153-98-0]; Down 200; 18.8uM; PC3; HT_HG-U133A

TCF7L2 CD101 MED25 ARID1A DDX6

2.32e-041976454673_DN
DrugSulfamonomethoxine [1220-83-3]; Up 200; 14.2uM; PC3; HT_HG-U133A

CYLD MED25 RCC1 ZCCHC2 RAD23B

2.32e-041976455843_UP
DrugTrichostatin A, from Streptomyces sp.; Down 200; 0.1uM; MCF7; HT_HG-U133A

TCF7L2 RTEL1 RCC1 CSTF2T RYR2

2.32e-041976453566_DN
DrugChloramphenicol [56-75-7]; Up 200; 12.4uM; PC3; HT_HG-U133A

MATR3 GON4L RCC1 CSTF2T RAD23B

2.32e-041976451795_UP
DrugNorgestrel-(-)-D [797-63-7]; Down 200; 12.8uM; MCF7; HT_HG-U133A

GLI3 NCOA1 RCC1 ARID1A SS18

2.32e-041976453406_DN
Drug2-Aminobenzenesulfonamide [3306-62-5]; Up 200; 23.2uM; HL60; HT_HG-U133A

RAG2 HEYL MED25 MEAK7 CREBBP

2.32e-041976453063_UP
DrugPNU-0293363 [326823-19-2]; Up 200; 10uM; PC3; HT_HG-U133A

CYLD MED25 RCC1 ARID1A CSTF2T

2.32e-041976456563_UP
DrugCarbarsone [121-59-5]; Down 200; 15.4uM; MCF7; HT_HG-U133A

GLI3 NCOA1 RCC1 MEAK7 CSTF2T

2.32e-041976453250_DN
DrugLymecycline [992-21-2]; Down 200; 6.6uM; MCF7; HT_HG-U133A

TCF7L2 RTEL1 NCOA1 CSTF2T DDX6

2.32e-041976455994_DN
DrugDiethylcarbamazine citrate [1642-54-2]; Down 200; 10.2uM; HL60; HT_HG-U133A

TCF7L2 RTEL1 ZNF174 MED25 NCOA1

2.38e-041986452394_DN
DrugButacaine [149-16-6]; Down 200; 13uM; MCF7; HT_HG-U133A

TCF7L2 GLI3 MFN2 NCOA1 RCC1

2.38e-041986456225_DN
DrugMethocarbamol [532-03-6]; Up 200; 16.6uM; PC3; HT_HG-U133A

COL9A2 ABL2 GLI3 MFN2 PLEKHA2

2.38e-041986452111_UP
DrugTacrine hydrochloride hydrate [1684-40-8]; Down 200; 15.8uM; MCF7; HT_HG-U133A

TCF7L2 RPS6KA4 ARID1A SS18 CSTF2T

2.38e-041986452633_DN
DrugICI 182,780; Up 200; 1uM; MCF7; HT_HG-U133A

TCF7L2 RTEL1 GLI3 MFN2 SS18

2.38e-041986456925_UP
DrugTrichlorfon [52-68-6]; Down 200; 15.6uM; HL60; HT_HG-U133A

MBTPS1 RPS6KA4 MATR3 MFN2 SS18

2.38e-041986451839_DN
DrugKetoconazole [65277-42-1]; Down 200; 7.6uM; MCF7; HT_HG-U133A

COL9A2 TCF7L2 RPS6KA4 MED25 RCC1

2.38e-041986452640_DN
DrugBendroflumethiazide [73-48-3]; Down 200; 9.4uM; HL60; HT_HG-U133A

MBTPS1 TCF7L2 RPS6KA4 CD101 NCOA1

2.38e-041986452555_DN
DrugProparacaine hydrochloride [5875-06-9]; Down 200; 12uM; PC3; HT_HG-U133A

MBTPS1 ZNF174 CHD8 EP300 CSTF2T

2.38e-041986456332_DN
DrugChlorhexidine [55-56-1]; Down 200; 8uM; MCF7; HT_HG-U133A

TCF7L2 RPS6KA4 RCC1 ARID1A CSTF2T

2.38e-041986451525_DN
DrugHexylcaine hydrochloride [532-76-3]; Down 200; 13.4uM; PC3; HT_HG-U133A

CYLD RCC1 ARID1A DDX6 RAD23B

2.38e-041986455768_DN
DrugProparacaine hydrochloride [5875-06-9]; Down 200; 12uM; MCF7; HT_HG-U133A

TCF7L2 RTEL1 GON4L CSTF2T RYR2

2.38e-041986455433_DN
DrugRicinine [524-40-3]; Up 200; 24.4uM; MCF7; HT_HG-U133A

CYLD RTEL1 NCOA1 GON4L SORCS3

2.38e-041986456206_UP
DrugChlorpropamide [94-20-2]; Up 200; 14.4uM; PC3; HT_HG-U133A

CYLD ABL2 ZNF174 MFN2 RYR2

2.38e-041986456291_UP
DrugButamben [94-25-7]; Up 200; 20.6uM; HL60; HT_HG-U133A

CYLD COL9A2 TCF7L2 MEAK7 CREBBP

2.38e-041986452531_UP
DrugSerotonin hydrochloride [153-98-0]; Up 200; 18.8uM; HL60; HT_HG-U133A

HEYL ZNF174 MED25 SS18 CREBBP

2.43e-041996452449_UP
DrugLeucomisine [17946-87-1]; Up 200; 16.2uM; MCF7; HT_HG-U133A

TCF7L2 ABL2 MED25 SORCS3 RCC1

2.43e-041996453546_UP
DrugRicinine [524-40-3]; Down 200; 24.4uM; PC3; HT_HG-U133A

TCF7L2 ZNF174 MED25 RCC1 SS18

2.43e-041996455725_DN
DrugPerphenazine [58-39-9]; Down 200; 10uM; PC3; HT_HG-U133A

CYLD MED25 SS18 DDX6 RAD23B

2.43e-041996454637_DN
DiseaseSezary Syndrome

KMT2C KMT2D ARID1A CREBBP

2.80e-0727614C0036920
DiseaseCarcinoma, Transitional Cell

KMT2C ARID1A CREBBP EP300

1.58e-0641614C0007138
DiseaseMenke-Hennekam syndrome

CREBBP EP300

4.20e-062612cv:C5681632
DiseaseRubinstein-Taybi syndrome (implicated_via_orthology)

CREBBP EP300

4.20e-062612DOID:1933 (implicated_via_orthology)
DiseaseRubinstein-Taybi syndrome

CREBBP EP300

4.20e-062612cv:C0035934
DiseaseKleefstra syndrome 2 (implicated_via_orthology)

KMT2C KMT2D

4.20e-062612DOID:0080598 (implicated_via_orthology)
DiseaseRUBINSTEIN-TAYBI SYNDROME 1

CREBBP EP300

4.20e-062612C4551859
DiseaseRUBINSTEIN-TAYBI SYNDROME 1

CREBBP EP300

4.20e-062612180849
DiseaseRubinstein-Taybi syndrome due to CREBBP mutations

CREBBP EP300

4.20e-062612cv:C4551859
DiseaseRubinstein-Taybi syndrome (is_implicated_in)

CREBBP EP300

4.20e-062612DOID:1933 (is_implicated_in)
DiseaseRubinstein-Taybi Syndrome

CREBBP EP300

4.20e-062612C0035934
DiseaseT-Cell Lymphoma

KMT2D ARID1A EP300

4.62e-0616613C0079772
DiseaseBladder Neoplasm

KMT2C KMT2D ARID1A CREBBP EP300

1.08e-05140615C0005695
DiseaseMalignant neoplasm of urinary bladder

KMT2C KMT2D ARID1A CREBBP EP300

1.11e-05141615C0005684
DiseaseKlatskin's tumor (is_implicated_in)

KMT2C ARID1A

4.19e-055612DOID:4927 (is_implicated_in)
DiseaseSquamous cell carcinoma of esophagus

KMT2C KMT2D CREBBP EP300

4.57e-0595614C0279626
DiseaseAdenoid Cystic Carcinoma

KMT2C ARID1A CREBBP EP300

5.59e-05100614C0010606
Diseasemood instability measurement

TCF7L2 TNRC6A SORCS3 EP300

1.46e-04128614EFO_0008475
DiseaseDiffuse Large B-Cell Lymphoma

KMT2D CREBBP EP300

2.04e-0455613C0079744
Diseasegastric adenocarcinoma (is_implicated_in)

KMT2D RTEL1

2.28e-0411612DOID:3717 (is_implicated_in)
DiseaseProstatic Neoplasms

KMT2C MBTPS1 KMT2D NCOA1 ARID1A CREBBP RAD23B

2.74e-04616617C0033578
DiseaseMalignant neoplasm of prostate

KMT2C MBTPS1 KMT2D NCOA1 ARID1A CREBBP RAD23B

2.74e-04616617C0376358
Diseaseprostate cancer (is_marker_for)

KMT2C KMT2D NCOA1 EP300

3.10e-04156614DOID:10283 (is_marker_for)
Diseasebreast carcinoma (is_marker_for)

KMT2D NCOA1 EP300

3.51e-0466613DOID:3459 (is_marker_for)
Diseasecongenital heart disease (implicated_via_orthology)

KMT2C KMT2D CHD8

4.00e-0469613DOID:1682 (implicated_via_orthology)
DiseaseLymphoma, Large-Cell, Follicular

KMT2D CREBBP

4.34e-0415612C0079745
DiseaseLymphoma, Small Cleaved-Cell, Follicular

KMT2D CREBBP

4.34e-0415612C0079765
DiseaseLymphoma, Mixed-Cell, Follicular

KMT2D CREBBP

4.34e-0415612C0079758
DiseaseLymphoma, Follicular, Grade 2

KMT2D CREBBP

4.34e-0415612C1956132
DiseaseLymphoma, Follicular, Grade 3

KMT2D CREBBP

4.34e-0415612C1956131
DiseaseLymphoma, Follicular, Grade 1

KMT2D CREBBP

4.34e-0415612C1956130
Diseasealcohol use disorder (implicated_via_orthology)

ARID1A CREBBP EP300 RYR2

7.19e-04195614DOID:1574 (implicated_via_orthology)
DiseaseLymphoma, Follicular

KMT2D CREBBP

7.80e-0420612C0024301
DiseaseLeft Ventricle Remodeling

TCF7L2 MFN2

8.61e-0421612C0600520
DiseaseVentricular Remodeling

TCF7L2 MFN2

8.61e-0421612C0600519
Diseasesex interaction measurement, bilirubin measurement

POU6F2 SORCS3

9.46e-0422612EFO_0004570, EFO_0008343
Diseaseglioma

RTEL1 D2HGDH

9.46e-0422612EFO_0005543
Diseaserisk-taking behaviour

GAPVD1 TCF7L2 EGR2 TNRC6A SORCS3 EP300 RYR2

9.84e-04764617EFO_0008579
DiseaseIntrahepatic Cholangiocarcinoma

KMT2C ARID1A

1.13e-0324612C0345905
DiseaseExtrahepatic Cholangiocarcinoma

KMT2C ARID1A

1.13e-0324612C3805278
DiseaseCholangiocarcinoma

KMT2C ARID1A

1.32e-0326612C0206698
DiseaseCarcinoma, Granular Cell

KMT2C TCF7L2 ARID1A

1.80e-03116613C0205644
DiseaseAdenocarcinoma, Tubular

KMT2C TCF7L2 ARID1A

1.80e-03116613C0205645
DiseaseAdenocarcinoma, Oxyphilic

KMT2C TCF7L2 ARID1A

1.80e-03116613C0205642
DiseaseCarcinoma, Cribriform

KMT2C TCF7L2 ARID1A

1.80e-03116613C0205643
DiseaseAdenocarcinoma, Basal Cell

KMT2C TCF7L2 ARID1A

1.80e-03116613C0205641
DiseaseAdenocarcinoma

KMT2C TCF7L2 ARID1A

1.80e-03116613C0001418
Diseaseatopic eczema

RTEL1 EGR2 MFN2 D2HGDH

1.85e-03252614EFO_0000274
Diseaseseasonal allergic rhinitis

ABL2 GLI3

2.00e-0332612EFO_0003956
Diseaseblood pressure, chronic obstructive pulmonary disease

HEYL TNRC6A

2.00e-0332612EFO_0000341, EFO_0004325

Protein segments in the cluster

PeptideGeneStartEntry
GVGGPGQVMASQAQQ

EP300

96

Q09472
GMLAAGNGQGIMPNQ

EP300

176

Q09472
GNGQGIMPNQVMNGS

EP300

181

Q09472
QGNMGQIGQLPQALG

EP300

2236

Q09472
PGGGGTQTQQQMNQL

DDX6

31

P26196
LDQMNQDGGGGDVGN

CHD8

46

Q9HCK8
MGQQVGRVGEAPGLQ

ABL2

1

P42684
IPNRQINDGMGGDGD

BEX3

51

Q00994
VPPGNGNIGNMQVVA

ACBD5

356

Q5T8D3
GNIGNMQVVAVEGKG

ACBD5

361

Q5T8D3
AQMGQLGQMGQPGLG

CREBBP

2266

Q92793
NMGNGTVFLGIPGDN

RAG2

321

P55895
GQGDVGQLGLGENVM

RCC1

41

P18754
FGENKMGQLGLGNQT

RCC2

226

Q9P258
QMLNEPVQEAGGQGG

RAD23B

326

P54727
GQLGMVQPGIGQQGM

QRICH2

741

Q9H0J4
NAELGGPFDQMNGVA

EGR2

41

P11161
QPTRVVQGMGQGTEG

IQCN

1076

Q9H0B3
AGGNVNVEMNATPGV

KRT26

236

Q7Z3Y9
NMLAFQPTHLQGGGG

MSGN1

96

A6NI15
GQGINSMAGMINPQG

ARID1A

931

O14497
MGGPIQASAEVAQQG

ARID1A

1481

O14497
MQGSGGQLNFGLPVA

GLI3

1286

P10071
GAGRPGQQMLGQISA

GLI3

1336

P10071
PAEGLQTLGAQMQGG

KMT2C

3816

Q8NEZ4
LGAGNGNLQGPRHMQ

MATR3

376

P43243
LNNPADQMDVIGVGG

MBTPS1

346

Q14703
LNMQLSDGGQGDVPV

GAPVD1

536

Q14C86
AAGGNVNVEMNAAPG

KRT27

236

Q7Z3Y8
AAGGNVNVEMNAAPG

KRT25

231

Q7Z3Z0
RGQGGMKANNNVFEP

KCNH4

186

Q9UQ05
LQQLMVRGGPAGGQN

EP400P1

46

Q6ZTU2
VRGGPAGGQNMNVDL

EP400P1

51

Q6ZTU2
AGGQNMNVDLQGVGP

EP400P1

56

Q6ZTU2
MNVDLQGVGPGLQGS

EP400P1

61

Q6ZTU2
GPIDVGQEGQLSQMA

HEYL

16

Q9NQ87
KLEQQQRGMGGQQAP

MED25

551

Q71SY5
GASGQGGQSQAAEIM

RPS6KA4

611

O75676
GQQTIPNGLGMGGQH

MEAK7

351

Q6P9B6
LVAGEMGQNEPDQGG

HSD17B10

131

Q99714
MGQNEPDQGGQRGVI

HSD17B10

136

Q99714
NARIQKAQGMPEGGG

MFN2

311

O95140
QHAGGQGAGPPQNQM

NCOA6

556

Q14686
QPEFVAGMGQDGIVQ

CD101

456

Q93033
APNQEGMVQAGGQGH

LINC00304

11

Q8N9R0
VGQMGSPGQQGASTQ

COL20A1

1266

Q9P218
GEIGPQGIMGQKGDQ

COL9A2

376

Q14055
SLGGGCNMIQPVNAA

GON4L

1156

Q3T8J9
KPINMENLPVNGGNG

GLB1L2

411

Q8IW92
GGMQGAGIQGVSIQG

CSTF2T

526

Q9H0L4
MADRDGGQNGFNIPQ

CYLD

891

Q9NQC7
GESMSPGQGRNNNGL

RYR2

1491

Q92736
ERNLAVNPQGGNTGM

D2HGDH

121

Q8N465
QFLDEMKGQGGAGGQ

RTEL1

661

Q9NZ71
PQNLAMGAGAVGALQ

PLEKHA2

46

Q9HB19
GNMNPEGGVNHENGM

RHOXF1

46

Q8NHV9
MIPEGGGGNQEPRQQ

RHOXF1

66

Q8NHV9
NMGNQNGNPTGTLGA

TNRC6C

136

Q9HCJ0
PQQGGGRGGEMQVEA

SORCS3

91

Q9UPU3
GNIGGQFGTGINPQM

NCOA1

1211

Q15788
NMAGQLGGQQGLVLT

POU6F2

126

P78424
VSGQGPVMENAQGLG

HDHD5

136

Q9BXW7
MGNVLQGGEGQAPTR

ACAT1

91

P24752
VGLNQMVPQIEGNTG

ZCCHC2

876

Q9C0B9
QQMLLEGGVNQEDGP

WDR47

451

O94967
PGGALMQGGTQQAIN

GTF2H1

436

P32780
GNGLQNPEPRGANMS

ZNF174

241

Q15697
NMPQGGGQHYQGQQP

SS18

216

Q15532
SHGGQGPPEGMNQQY

SS18

276

Q15532
MPQLNGGGGDDLGAN

TCF7L2

1

Q9NQB0
GGYGNLLMNSEQPQG

NUP188

661

Q5SRE5
GIQPMGQDSGSQAQG

PLEKHH1

196

Q9ULM0
GEAIGKMQQQGIPGG

ZNF41

141

P51814
GVGNTAAQPRGMQQP

TNRC6A

1336

Q8NDV7
VLQNVGGGEAGPQEM

ZNF628

801

Q5EBL2
MLSGQHGGQAGLVPQ

KMT2D

3356

O14686
QGSIGVAPGMNRQQV

KMT2D

3441

O14686