Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyCellularComponentGATOR2 complex

SEH1L CASTOR1 SZT2 SESN3

4.69e-06122114GO:0061700
GeneOntologyCellularComponentcollagen-containing extracellular matrix

ASPN HAPLN4 ITGA6 ZP3 ITGB4 ITIH1 ITIH2 ITIH4 SLIT2 SERPINA1 PXDN FGF9 PZP USH2A FRAS1 ADAMTS3 ADAMTS2 MMP28

7.81e-0653021118GO:0062023
GeneOntologyCellularComponentSeh1-associated complex

SEH1L CASTOR1 SZT2 SESN3

1.67e-05162114GO:0035859
GeneOntologyCellularComponentearly endosome

ZFYVE16 KCNH1 BAIAP3 ATP13A4 ALS2 STAM ECPAS OR51E2 USP10 VAC14 LLGL1 NISCH SIGLEC1 HAS3 VPS13B

1.18e-0448121115GO:0005769
GeneOntologyCellularComponentextracellular matrix

ASPN HAPLN4 ITGA6 ZP3 ITGB4 ITIH1 ITIH2 ITIH4 SLIT2 SERPINA1 PXDN FGF9 PZP USH2A FRAS1 ADAMTS3 ADAMTS2 MMP28

1.26e-0465621118GO:0031012
GeneOntologyCellularComponentexternal encapsulating structure

ASPN HAPLN4 ITGA6 ZP3 ITGB4 ITIH1 ITIH2 ITIH4 SLIT2 SERPINA1 PXDN FGF9 PZP USH2A FRAS1 ADAMTS3 ADAMTS2 MMP28

1.31e-0465821118GO:0030312
GeneOntologyCellularComponentearly endosome membrane

ZFYVE16 KCNH1 BAIAP3 ATP13A4 STAM OR51E2 VAC14 LLGL1 VPS13B

3.15e-042122119GO:0031901
GeneOntologyCellularComponentvacuole

HEXB SEH1L SPNS1 ARSK NCF2 ACE SHKBP1 TMEM150C TRPV3 RAB2A SZT2 CUBN CRYAB CD1C VAC14 LRP2 RAB2B PADI2 MMD CTSW VPS13B

3.90e-0491321121GO:0005773
GeneOntologyCellularComponentlysosome

HEXB SEH1L SPNS1 ARSK NCF2 ACE SHKBP1 TMEM150C TRPV3 RAB2A SZT2 CUBN CRYAB CD1C LRP2 PADI2 MMD CTSW VPS13B

5.95e-0481121119GO:0005764
GeneOntologyCellularComponentlytic vacuole

HEXB SEH1L SPNS1 ARSK NCF2 ACE SHKBP1 TMEM150C TRPV3 RAB2A SZT2 CUBN CRYAB CD1C LRP2 PADI2 MMD CTSW VPS13B

5.95e-0481121119GO:0000323
DomainITI_HC_C

ITIH1 ITIH2 ITIH4

2.73e-0562103IPR010600
DomainITI_HC_C

ITIH1 ITIH2 ITIH4

2.73e-0562103PF06668
DomainVIT

ITIH1 ITIH2 ITIH4

7.53e-0582103PF08487
DomainVIT

ITIH1 ITIH2 ITIH4

7.53e-0582103SM00609
DomainVac14_Fab1-bd

ECPAS VAC14

1.26e-0422102IPR032878
DomainK_chnl_volt-dep_EAG

KCNH1 KCNH5

1.26e-0422102IPR003949
DomainVac14_Fab1_bd

ECPAS VAC14

1.26e-0422102PF12755
DomainFSH_rcpt

SLIT2 FSHR

1.26e-0422102IPR002272
DomainVIT

ITIH1 ITIH2 ITIH4

1.59e-04102103PS51468
DomainVIT

ITIH1 ITIH2 ITIH4

1.59e-04102103IPR013694
DomainGART_AS

GART ALDH1L1

3.75e-0432102IPR001555
DomainGART

GART ALDH1L1

3.75e-0432102PS00373
Pubmed

Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.

SEH1L SPNS1 EMC7 SRP54 CLASP2 DNAJC6 RSU1 BRAP CLPB SUPT6H TMEM131L SEMA6A ASCC3 FRAS1 CAD SLC4A7 POLE2 POLR1C ZDHHC5 TARS2 SLC5A3 USP10 LLGL1 N4BP2 EPHA2 NISCH ATM CRYBG3 NEURL4 VPS13B

1.05e-0814872133033957083
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

GTPBP6 TDH SRP54 CLASP2 ZP3 RSU1 SHKBP1 PHKB PXDN SH3TC1 SUPT6H SEMA6A XYLB BAIAP3 TBCD SMG6 PRUNE2 BEST1 PSAT1 CHD9 G2E3 TARS2 ECPAS PCDHB16 SPTBN4 OR51E2 USP10 PCNX4 ASMTL VPS13B

1.08e-0814892133028611215
Pubmed

LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.

ITGB4 PHKB PXDN ASCC3 FLNA CAD SMCHD1 XPO1 ECPAS NEURL4

5.38e-072022131033005030
Pubmed

Functional analysis of secreted and transmembrane proteins critical to mouse development.

ITGA6 BIRC6 FAT1 SEMA6A EPHA2

1.23e-0631213511431694
Pubmed

Multiple cadherins are expressed in human fibroblasts.

FAT1 PCDHGA12 DCHS1

2.24e-06521339199196
Pubmed

alpha3beta1 and alpha6beta4 integrin receptors for laminin-5 are not essential for epidermal morphogenesis and homeostasis during skin development.

ITGA6 ITGB4 MKI67

4.47e-066213310934043
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

GTPBP6 CLASP2 BIRC6 ITGB4 FAT1 SH3TC1 TBCD SMG6 FLNA CRYBG2 FRAS1 B4GALNT4 SZT2 ZDHHC5 EML3 PHC2 VAC14 PCNX4 NISCH ZNF335 HAS3

5.00e-0611052132135748872
Pubmed

The DNA sequence and biological annotation of human chromosome 1.

NCF2 RO60 CSMD2 DNAJC6 PTGFR PTGS2 PGM1 EVI5 KCNJ9 USH2A NIBAN1 CRYBG2 SZT2 TARS2 OR6P1 KMO PHC2 CD1C VASH2 PADI2

6.30e-0610312132016710414
Pubmed

Proteome-wide characterization of N-glycosylation events by diagonal chromatography.

ACE ITIH1 ITIH2 SERPINA1 BTD PZP

8.12e-0677213616944957
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

ZFYVE16 GPATCH8 DNAJC6 SLC12A5 PXDN BAIAP3 VCPIP1 FRAS1 ALS2 PCDHB16 NISCH VPS13B

9.03e-064072131212693553
Pubmed

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.

HEXB ALDH1L1 ACE ITIH1 ITIH2 ITIH4 PGM1 SERPINA1 PXDN BTD CAPN5 PZP RAB2A FLNA NIBAN1 CUBN CRYAB SPTBN4 LRP2 RAB2B

1.08e-0510702132023533145
Pubmed

Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.

SPNS1 ZFYVE16 BIRC6 ASCC3 VCPIP1 FLNA ECPAS PHC1 PPM1F N4BP2 LRP2 CRYBG3

1.18e-054182131234709266
Pubmed

A Multipronged Unbiased Strategy Guides the Development of an Anti-EGFR/EPHA2-Bispecific Antibody for Combination Cancer Therapy.

HEXB CDK16 ITGA6 MCM2 PLCB1 SEMA6A SLC4A7 ZDHHC5 STAM LLGL1 EPHA2 NISCH

1.27e-054212131236976175
Pubmed

Defining the human deubiquitinating enzyme interaction landscape.

SEH1L THNSL1 POLR3H OTUD1 MCM2 CLASP2 SHKBP1 CLPB SUPT6H ASCC3 VCPIP1 FLNA POLR1C DPP3 USP10 IPO9 MPHOSPH9 NUDCD1 NEURL4

1.55e-0510052131919615732
Pubmed

Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling.

HEXB SPNS1 EMC7 GTPBP6 ZFYVE16 GART SRP54 MCM2 BIRC6 FAT1 PXDN MKI67 MICA RAB2A FLNA CAD SMCHD1 XPO1 STAM ANKZF1 GLMN USP10

1.74e-0512972132233545068
Pubmed

Recent acquisition of imprinting at the rodent Sfmbt2 locus correlates with insertion of a large block of miRNAs.

RSU1 ITIH2 STAM CUBN

2.15e-0527213421510876
Pubmed

LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.

EMC7 RO60 SLIT2 PXDN ASCC3 TBCD VCPIP1 FLNA POLR1C XPO1 TARS2 ECPAS GLMN VAC14 IPO9 PPM1F EPHA2 NISCH

2.27e-059422131831073040
Pubmed

A Single Adaptable Cochaperone-Scaffold Complex Delivers Nascent Iron-Sulfur Clusters to Mammalian Respiratory Chain Complexes I-III.

SPNS1 THNSL1 ALDH1L1 BIRC6 GGCX SLIT2 MIPEP SEMA6A CAD NDUFAF5 POLR1C TARS2 VAC14 LLGL1 NISCH

2.44e-056862131528380382
Pubmed

Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study.

HEXB BIRC6 PGM1 ADH4 PXDN MKI67 PRUNE2 LRP2 SIGLEC1 KCNH5

2.59e-053132131020800603
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

SANBR MCM2 SUPT6H PLCB1 TMEM131L SMG6 SZT2 SMCHD1 G2E3 ECPAS USP10 PPM1F PADI2

2.62e-055292131314621295
Pubmed

Expression and localization of Inter-alpha Inhibitors in rodent brain.

ITIH1 ITIH2 ITIH4

2.63e-0510213326964679
Pubmed

Genetic polymorphisms and susceptibility to lung disease.

CYBB NCF2 SERPINA1

2.63e-0510213316608528
Pubmed

Voltage-gated potassium channel EAG2 controls mitotic entry and tumor growth in medulloblastoma via regulating cell volume dynamics.

KCNH1 MKI67 KCNH5

2.63e-0510213322855790
Pubmed

Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.

ZFYVE16 ITGA6 CLASP2 BIRC6 SHKBP1 PHKB MKI67 PSAT1 CAD ZDHHC5 XPO1 STAM TARS2 GLMN IPO9 PPM1F MPHOSPH9 CRYBG3 NEURL4

2.78e-0510492131927880917
Pubmed

Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals.

ALDH1L1 ACE DNAJC6 SLIT2 PXDN TBCD SPTBN4

2.89e-05142213719851296
Pubmed

Association of genetic variants with hemorrhagic stroke in Japanese individuals.

ALDH1L1 ACE DNAJC6 SLIT2 PXDN TBCD SPTBN4

3.03e-05143213720198315
Pubmed

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.

DLGAP2 CLASP2 DNAJC6 ITIH1 ITIH4 SLC12A5 KCNA4 PLCB1 RAB2A SMG6 CAD PAK5 SPTBN4 USP10 N4BP2 NISCH DCHS1 NEURL4

3.03e-059632131828671696
Pubmed

Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

BCHE ACE F5 ITGB4 ITIH2 ITIH4 SERPINA1 BTD PZP

3.23e-05257213916335952
Pubmed

A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.

SEH1L SPNS1 ZFYVE16 MCM2 DNAJC6 SHKBP1 SERPINA1 CLPB TMEM131L ASCC3 VCPIP1 FLNA SMCHD1 POLE2 XPO1 ECPAS EPHA2 PADI2

3.51e-059742131828675297
Pubmed

Thy1 marks a distinct population of slow-cycling stem cells in the mouse epidermis.

ITGA6 ITGB4 MKI67

3.60e-0511213335941116
Pubmed

Molecular cloning and characterization of a novel human Rab ( Rab2B) gene.

RAB2A RAB2B

3.73e-052213212376746
Pubmed

Effect of the angiotensin-converting enzyme gene deletion polymorphism on the risk of venous thromboembolism.

ACE F5

3.73e-052213211122103
Pubmed

Neutrophils regulate tissue Neutrophilia in inflammation via the oxidant-modified lipid lysophosphatidylserine.

CYBB GPR132

3.73e-052213223293064
Pubmed

Keratinocytes display normal proliferation, survival and differentiation in conditional beta4-integrin knockout mice.

ITGA6 ITGB4

3.73e-052213215731010
Pubmed

Expression and immunolocalisation of the endocytic receptors megalin and cubilin in the human yolk sac and placenta across gestation.

CUBN LRP2

3.73e-052213223978537
Pubmed

Hypermethylated DNA as potential biomarkers for gastric cancer diagnosis.

KCNA4 CYP26B1

3.73e-052213221945024
Pubmed

Lethal junctional epidermolysis bullosa with pyloric atresia due to compound heterozygosity for two novel mutations in the integrin β4 gene.

ITGA6 ITGB4

3.73e-052213221969027
Pubmed

Epidermal α6β4 integrin stimulates the influx of immunosuppressive cells during skin tumor promotion.

ITGA6 ITGB4

3.73e-052213222464766
Pubmed

A novel phenotype in a family with autosomal dominant retinal dystrophy due to c.1430A > G in retinoid isomerohydrolase (RPE65) and c.37C > T in bestrophin 1 (BEST1).

BEST1 RPE65

3.73e-052213233512609
Pubmed

Evaluation of the roles of the Leiden V mutation and ACE I/D polymorphism in subtypes of ischaemic stroke.

ACE F5

3.73e-052213211596779
Pubmed

Phenotypic spectrum of epidermolysis bullosa associated with α6β4 integrin mutations.

ITGA6 ITGB4

3.73e-052213223496044
Pubmed

CUBN is a gene locus for albuminuria.

RSU1 CUBN

3.73e-052213221355061
Pubmed

[Semaphorin/plexin signal regulates lamina-restricted projection of hippocampal mossy fiber].

SEMA6A PLXNA4

3.73e-052213221089322
Pubmed

Analysis of the tumor-associated antigen TSP-180. Identity with alpha 6-beta 4 in the integrin superfamily.

ITGA6 ITGB4

3.73e-05221322475502
Pubmed

Acute endotoxemia in mice induces downregulation of megalin and cubilin in the kidney.

CUBN LRP2

3.73e-052213222437417
Pubmed

Genetic screen in Drosophila muscle identifies autophagy-mediated T-tubule remodeling and a Rab2 role in autophagy.

RAB2A RAB2B

3.73e-052213228063257
Pubmed

Correlation of Ki-67 and MCM-2 proliferative marker expression with grade of histological malignancy (G) in ductal breast cancers.

MCM2 MKI67

3.73e-052213221097442
Pubmed

Integrin alpha6 maintains the structural integrity of the kidney collecting system.

ITGA6 ITGB4

3.73e-052213228043890
Pubmed

A novel integrin (alpha E beta 4) from human epithelial cells suggests a fourth family of integrin adhesion receptors.

ITGA6 ITGB4

3.73e-05221322542022
Pubmed

Expression and Significance of COX-2 and Ki-67 in Hepatolithiasis with Bile Duct Carcinoma.

PTGS2 MKI67

3.73e-052213226423666
Pubmed

Dynamics of the alpha6beta4 integrin in keratinocytes.

ITGA6 ITGB4

3.73e-052213212429829
Pubmed

Expression and role of cubilin in the internalization of nutrients during the peri-implantation development of the rodent embryo.

CUBN LRP2

3.73e-052213215616221
Pubmed

The heavy chains of human plasma inter-alpha-trypsin inhibitor: their isolation, their identification by electrophoresis and partial sequencing. Differential reactivity with concanavalin A.

ITIH1 ITIH2

3.73e-05221321384548
Pubmed

The 3'UTR of the α6 integrin message regulates localization of α6β4 integrin heterodimers.

ITGA6 ITGB4

3.73e-052213230922568
Pubmed

Plexin-A4 Mediates Cytotoxic T-cell Trafficking and Exclusion in Cancer.

SEMA6A PLXNA4

3.73e-052213234815265
Pubmed

Curcumin inhibition of the functional interaction between integrin α6β4 and the epidermal growth factor receptor.

ITGA6 ITGB4

3.73e-052213221388972
Pubmed

Expression profiling of metalloproteinases and their inhibitors in cartilage.

ADAMTS2 MMP28

3.73e-052213214730609
Pubmed

Epithelial integrin alpha 6 beta 4: complete primary structure of alpha 6 and variant forms of beta 4.

ITGA6 ITGB4

3.73e-05221321976638
Pubmed

Alpha 6 beta 4 integrin abnormalities in junctional epidermolysis bullosa with pyloric atresia.

ITGA6 ITGB4

3.73e-052213211251584
Pubmed

α6β4 integrin, a master regulator of expression of integrins in human keratinocytes.

ITGA6 ITGB4

3.73e-052213222493440
Pubmed

Characterization of an epithelial approximately 460-kDa protein that facilitates endocytosis of intrinsic factor-vitamin B12 and binds receptor-associated protein.

CUBN LRP2

3.73e-05221329334227
Pubmed

Molecular cloning of the human alpha 6 integrin subunit. Alternative splicing of alpha 6 mRNA and chromosomal localization of the alpha 6 and beta 4 genes.

ITGA6 ITGB4

3.73e-05221322070796
Pubmed

Silencing megalin and cubilin genes inhibits myeloma light chain endocytosis and ameliorates toxicity in human renal proximal tubule epithelial cells.

CUBN LRP2

3.73e-052213218448595
Pubmed

A novel αB-crystallin R123W variant drives hypertrophic cardiomyopathy by promoting maladaptive calcium-dependent signal transduction.

CRYAB MYBPC3

3.73e-052213237435054
Pubmed

Compartmentalization of integrin alpha6beta4 signaling in lipid rafts.

ITGA6 ITGB4

3.73e-052213214517202
Pubmed

Endothelial α6β4 integrin protects during experimental autoimmune encephalomyelitis-induced neuroinflammation by maintaining vascular integrity and tight junction protein expression.

ITGA6 ITGB4

3.73e-052213229121970
Pubmed

Comparative interactomics analysis reveals potential regulators of α6β4 distribution in keratinocytes.

ITGA6 ITGB4

3.73e-052213232709696
Pubmed

Clinical, functional and genetic analysis of twenty-four patients with chronic granulomatous disease - identification of eight novel mutations in CYBB and NCF2 genes.

CYBB NCF2

3.73e-052213222562447
Pubmed

The macrophage odorant receptor Olfr78 mediates the lactate-induced M2 phenotype of tumor-associated macrophages.

GPR132 OR51E2

3.73e-052213234504016
Pubmed

Mutation analysis of 3 genes in patients with Leber congenital amaurosis.

BEST1 RPE65

3.73e-052213210766140
Pubmed

Hemidesmosomes modulate force generation via focal adhesions.

ITGA6 ITGB4

3.73e-052213231914171
Pubmed

Photoreceptor Cell-Derived CAPN5 Regulates Retinal Pigment Epithelium Cell Proliferation Through Direct Regulation of SLIT2 Cleavage.

SLIT2 CAPN5

3.73e-052213229610848
Pubmed

Polymorphisms in LRP2 and CUBN genes and their association with serum vitamin D levels and sleep apnea.

CUBN LRP2

3.73e-052213238008818
Pubmed

Megalin and cubilin in the human gallbladder epithelium.

CUBN LRP2

3.73e-052213218791690
Pubmed

Functional distinction of human EAG1 and EAG2 potassium channels.

KCNH1 KCNH5

3.73e-052213211943152
Pubmed

Megalin and cubilin: multifunctional endocytic receptors.

CUBN LRP2

3.73e-052213211994745
Pubmed

Megalin acts in concert with cubilin to mediate endocytosis of high density lipoproteins.

CUBN LRP2

3.73e-052213210766831
Pubmed

Posttranslational modifications of human inter-alpha-inhibitor: identification of glycans and disulfide bridges in heavy chains 1 and 2.

ITIH1 ITIH2

3.73e-05221329425062
Pubmed

Role of prostaglandin H2 synthase 2 in murine parturition: study on ovariectomy-induced parturition in prostaglandin F receptor-deficient mice.

PTGFR PTGS2

3.73e-052213212620936
Pubmed

Cubilin and megalin expression and their interaction in the rat intestine: effect of thyroidectomy.

CUBN LRP2

3.73e-052213211595644
Pubmed

FSH-regulated gene expression profiles in ovarian tumours and normal ovaries.

PTGS2 FSHR

3.73e-052213211994539
Pubmed

Prostaglandin E2 and F2alpha activate the FP receptor and up-regulate cyclooxygenase-2 expression via the cyclic AMP response element.

PTGFR PTGS2

3.73e-052213218316157
Pubmed

Serine 249 phosphorylation by ATM protein kinase regulates hepatocyte nuclear factor-1α transactivation.

HNF1A ATM

3.73e-052213224821553
Pubmed

Integrin alpha 6 is upregulated and drives hepatocellular carcinoma progression through integrin α6β4 complex.

ITGA6 ITGB4

3.73e-052213235657344
Pubmed

The frequency of factor V Leiden mutation, ACE gene polymorphism, serum ACE activity and response to ACE inhibitor and angiotensin II receptor antagonist drugs in Iranians type II diabetic patients with microalbuminuria.

ACE F5

3.73e-052213220853144
Pubmed

ROS1-Rearranged Non-Small-Cell Lung Cancer, Factor V Leiden, and Recurrent Venous Thromboses.

F5 ROS1

3.73e-052213229945753
Pubmed

Glycosylation pattern of human inter-alpha-inhibitor heavy chains.

ITIH1 ITIH2

3.73e-05221329677337
Pubmed

A Cys-Gly-Cys triad in the dehydrogenase region of Nox2 plays a key role in the interaction with p67phox.

CYBB NCF2

3.73e-052213226160850
Pubmed

Activation of the flavoprotein domain of gp91phox upon interaction with N-terminal p67phox (1-210) and the Rac complex.

CYBB NCF2

3.73e-052213215260500
Pubmed

A key tyrosine (Y1494) in the beta4 integrin regulates multiple signaling pathways important for tumor development and progression.

ITGA6 ITGB4

3.73e-052213218974120
Pubmed

Mobilization and activation of a signaling competent alpha6beta4integrin underlies its contribution to carcinoma progression.

ITGA6 ITGB4

3.73e-052213216258729
Pubmed

HPV16 infection of HaCaTs is dependent on β4 integrin, and α6 integrin processing.

ITGA6 ITGB4

3.73e-052213224418536
Pubmed

α6β4 Integrin Regulates the Collective Migration of Epithelial Cells.

ITGA6 ITGB4

3.73e-052213227922761
Pubmed

Role of megalin and cubilin in the metabolism of vitamin D(3).

CUBN LRP2

3.73e-052213221595846
Pubmed

Differential distribution of cubilin and megalin expression in the mouse embryo.

CUBN LRP2

3.73e-052213214983511
Pubmed

Role for the first SH3 domain of p67phox in activation of superoxide-producing NADPH oxidases.

CYBB NCF2

3.73e-052213219116138
Pubmed

α6β4 Integrin Genetic Variations (A380T and R1281W) and Breast Cancer Risk in an Argentinian Population.

ITGA6 ITGB4

3.73e-052213227763564
Pubmed

Association Analysis of the Cubilin (CUBN) and Megalin (LRP2) Genes with ESRD in African Americans.

CUBN LRP2

3.73e-052213227197912
Pubmed

Developmentally regulated expression of the beta 4 integrin on immature mouse thymocytes.

ITGA6 ITGB4

3.73e-05221321385605
Pubmed

Expression of the beta 4 integrin subunit in the mouse heart during embryonic development: retinoic acid advances beta 4 expression.

ITGA6 ITGB4

3.73e-05221328875079
InteractionFBXO2 interactions

HEXB EMC7 ARSK ITGA6 BCHE ASIC5 GGCX BRAP SLIT2 SERPINA1 PXDN BTD TMEM131L SEMA6A FRAS1 SLC4A7 ECPAS LRP2 MMD SERPINA9

7.08e-0941120320int:FBXO2
GeneFamilyBeta-gamma crystallin domain containing

CRYBG2 CRYBG3

1.80e-04314121360
ToppCellhealthy_donor-Myeloid-Monocytic-Neutrophil|healthy_donor / Disease condition, Lineage, Cell class and subclass

TRPM6 NCF2 PTGS2 FAM157A BEST1 NIBAN1 SMCHD1 PHC2 PADI2

1.24e-07168213904259f5a9b067cd1b5619e34591e4b2fccc18535
ToppCelldroplet-Kidney-KIDNEY-30m-Epithelial-collecting_duct_principal_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ITGB4 KCNH1 CAPN5 FRAS1 ADAMTS3 PCDHGA4 SLCO5A1 VASH2 HAS3

2.34e-0718121397af469f5bcb9b1ab3f35b2758bf2afb87e8eba57
ToppCell21-Trachea-Mesenchymal-Mesenchyme_SERPINF1-high|Trachea / Age, Tissue, Lineage and Cell class

ASPN BCHE ANO5 KCNA4 FGF9 ADAMTS2 MMP28 CRYAB WSCD2

2.46e-071822139354dcdb01360597f68c4fe157a682aee1c0b8bb1
ToppCellcontrol-Myeloid-Neutrophils_4|control / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

NCF2 PTGS2 SHKBP1 SERPINA1 NIBAN1 SMCHD1 PHC2 MIDN PADI2

3.23e-07188213922d76c222fb0e3da08e10191af0090f14e03f2ad
ToppCellcontrol-Myeloid-Neutrophils_1|control / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

NCF2 PTGS2 SHKBP1 SERPINA1 NIBAN1 SMCHD1 PHC2 MIDN PADI2

4.59e-0719621399c8623232c47af5de9f360fd5c5113362e37c6c9
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_1_/_Segment_2|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ALDH1L1 OR2T10 SLIT2 XYLB PRUNE2 CUBN KMO LRP2

1.54e-061682138fa0d251693935116adf633d02b7ec4a295100865
ToppCelldroplet-Pancreas-Exocrine-18m-Epithelial|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

BCHE PTGFR ITGB4 SEMA6A DNAH6 FLNA CRYAB TRIM47

1.75e-0617121385447b78148f7bccb727e2fc108589b2af02a5d31
ToppCelldroplet-Pancreas-Exocrine-18m-Epithelial-pancreatic_ductal_cel|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

BCHE PTGFR ITGB4 SEMA6A DNAH6 FLNA CRYAB TRIM47

1.83e-061722138a7eee0a30d2fe20c865a07b9004c6a821a72c0c4
ToppCelldroplet-Pancreas-Exocrine-18m-Epithelial-pancreatic_ductal_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

BCHE PTGFR ITGB4 SEMA6A DNAH6 FLNA CRYAB TRIM47

1.83e-0617221380a9fe2cd28203970295a1288078c66eadac1c9ed
ToppCellPBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Myeloid-Granulocytic-Neutrophil-Neu_c1-IL1B|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)

CYBB NCF2 F5 PTGS2 SLIT2 SERPINA1 BEST1 CABP7

1.83e-0617221380b247fe57163af08132db8df42e6757699885295
ToppCell(00)_Basal-(1)_24hpi|(00)_Basal / shred by cell type and Timepoint

MCM2 F5 PTGS2 FLNA PSAT1 MMS22L EPHA2 TRIM47

1.91e-061732138a8e62e7d8baf6af691acd5c50deedbadc119ceba
ToppCell3'-Broncho-tracheal-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophages-Alveolar_macrophages_L.1.0.3.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

HEXB SPNS1 NCF2 SERPINA1 FLNA OR51E2 SIGLEC1 MYBPC3

2.37e-0617821380b398656f26c4061b11ccf98908d0e2e1367585a
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_3-Exc_L3_RORB_CARTPT|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SLIT2 TMEM150C TMEM131L SEMA6A BAIAP3 ROS1 CRYBG3 KCNH5

2.57e-0618021385e78b29fa1cbdcf502fee3577e5b45766b90d1dc
ToppCellCOVID-19-kidney-PCT-S1|COVID-19 / Disease (COVID-19 only), tissue and cell type

ALDH1L1 OR2T10 FAT1 XYLB PRUNE2 FRAS1 CUBN LRP2

2.91e-0618321386878d14026c3df6aa12e45dfad94b32fa9d9b0b7
ToppCell5'-Adult-LargeIntestine-Mesenchymal-myocytic-myofibroblast_(RSPO2+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ASPN BCHE PRUNE2 FLNA NIBAN1 FRAS1 CRYAB OR51E2

2.91e-06183213861a73de857f4ae02dcba3af348f436f602b28ff2
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ANO5 FAT1 KCNA4 USH2A ATP13A4 FRAS1 LRP2 ROS1

3.03e-0618421382cbed6462fea2622871bb7e49b0df3d984239281
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ANO5 FAT1 KCNA4 USH2A ATP13A4 FRAS1 LRP2 ROS1

3.03e-0618421382b19a8c5f823e00812908b23e66bb4e563278aff
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ANO5 FAT1 KCNA4 USH2A ATP13A4 FRAS1 LRP2 ROS1

3.03e-061842138ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ALDH1L1 OR2T10 SLIT2 XYLB PRUNE2 HNF1A CUBN LRP2

3.28e-0618621388287146f0ba415ea04475588117d4668ae00f75c
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ALDH1L1 OR2T10 SLIT2 XYLB PRUNE2 HNF1A CUBN LRP2

3.41e-06187213871eb26ebf60cb0848e5bf1cd01edccda621aecd8
ToppCellE18.5-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP1|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ACE SH3TC1 PLCB1 SMG6 SZT2 CHD9 VAC14 MPHOSPH9

3.41e-0618721383699d5e71d779da922920aa3160895db187bf81b
ToppCellE18.5-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP1-CAP1_mature|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ACE SH3TC1 PLCB1 SMG6 SZT2 CHD9 VAC14 MPHOSPH9

3.41e-061872138033ba52c0c2f9978784947098fa697368ae44834
ToppCellPBMC-Severe-Myeloid-Neutrophil-Neutrophil-Neu_0|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

NCF2 PTGS2 SERPINA1 FBXL18 BEST1 NIBAN1 SMCHD1 PADI2

3.41e-06187213875bc05a0ba2727fecc236903ace792a28f3d3c9a
ToppCellCOVID-19-kidney-Stressed_PCT|kidney / Disease (COVID-19 only), tissue and cell type

HEXB SLIT2 XYLB PRUNE2 PSAT1 SESN3 CUBN LRP2

3.41e-061872138acd305475f3609800af0d7bc68d83ef41228080b
ToppCellPBMC-Severe-Myeloid-Neutrophil-Neutrophil-Neu_0|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

NCF2 PTGS2 SERPINA1 FBXL18 BEST1 NIBAN1 SMCHD1 PADI2

3.41e-061872138a0d59bf1043ff5a1e8110b39ecc2d3932675edd4
ToppCellSmart-seq2-spleen_(Smart-seq2)-myeloid-myeloid_monocytic|spleen_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

CYBB NCF2 PTGS2 SERPINA1 SH3TC1 FLNA ADAMTS2 PHC2

3.84e-06190213800ef6ec71353e42260c0d807d7da65b63154c288
ToppCellSmart-seq2-spleen_(Smart-seq2)-myeloid-myeloid_monocytic-classical_monocyte|spleen_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

CYBB NCF2 PTGS2 SERPINA1 SH3TC1 FLNA ADAMTS2 PHC2

3.84e-06190213818c020ca9a23399214133ec255ab870e0060f2e1
ToppCellSmart-seq2-spleen_(Smart-seq2)-myeloid|spleen_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

CYBB NCF2 PTGS2 SERPINA1 SH3TC1 FLNA ADAMTS2 PHC2

4.31e-0619321385f732598cdb6f3bd519f044a9cc553bd2e8b1052
ToppCellTCGA-Prostate-Primary_Tumor-Prostate_Adenocarcinoma-Acinar_Adenocarcinoma-6|TCGA-Prostate / Sample_Type by Project: Shred V9

ZFYVE16 NBEAL1 RO60 BIRC6 G2E3 N4BP2 CRYBG3 VPS13B

4.31e-061932138abd71b2cf667ef2b1c4d88acd0c1dd19a12ff659
ToppCellcontrol-Myeloid-Neutrophils_3|control / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

NCF2 F5 SHKBP1 SERPINA1 NIBAN1 PHC2 USP10 PADI2

4.31e-06193213856daf3c59a124dd068af5409113913d9ee81a454
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22-Myeloid-Monocytic-Classical_Monocyte-Mono_c3-CD14-VCAN|Severe-critical_progression_d12-22 / Compartment, severity and other cell annotations on 10x 3' data (130k)

CYBB OTUD1 NCF2 PTGS2 SERPINA1 BEST1 PHC2 PADI2

4.83e-061962138782aa9e75ad032627d95dba763a37ae2b1f7f503
ToppCellmild-Myeloid-Neutrophils_4|mild / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

NCF2 PTGS2 SERPINA1 NIBAN1 SMCHD1 PHC2 MIDN PADI2

4.83e-061962138f8c98cded5550843322b1711e1a57c7e88cae861
ToppCellsaliva-Mild-Moderate_progression_d12-25-Myeloid-Granulocytic-Neutrophil-Neu_c1-IL1B|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

NCF2 PTGS2 SERPINA1 FLNA BEST1 NIBAN1 SMCHD1 USP10

5.01e-0619721383cd1c816bc7a57278b2ef615b69545356ab8f522
ToppCellLPS_anti-TNF-Mesenchymal_myocytic-Myofibroblastic|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

ASPN BCHE FAT1 PZP PRUNE2 FLNA CRYAB PLXNA4

5.40e-061992138e9820d5fb4e8b46973c4c50ac5db8fb4a1bf603b
ToppCellCOVID-19-COVID-19_Mild-Myeloid-Neutrophil|COVID-19_Mild / Disease, condition lineage and cell class

NCF2 F5 PTGS2 FBXL18 BEST1 NIBAN1 SMCHD1 PADI2

5.40e-0619921389f6b6731186ef399f952a75879eba66fd8ed3494
ToppCellParenchymal-10x5prime-Immune_Myeloid-Macrophage_alveolar-Macro_alv_dividing|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

CYBB HEXB MCM2 NCF2 SERPINA1 BEST1 SIGLEC1 MMD

5.60e-0620021380cf7208eab0dc58fbea35e256c5cb55cdd4a4928
ToppCellControl_saline-Mesenchymal_myocytic-Myofibroblastic|Control_saline / Treatment groups by lineage, cell group, cell type

ASPN PTGFR FAT1 PZP PRUNE2 FLNA CRYAB PLXNA4

5.60e-0620021389d5b3c2dcfa55d50acc2ce2c319d51aa525d4cd1
ToppCellCOVID-19-COVID-19_Severe-Myeloid-Neutrophil|COVID-19_Severe / Disease, condition lineage and cell class

NCF2 PTGS2 SERPINA1 FBXL18 BEST1 NIBAN1 SMCHD1 PADI2

5.60e-062002138fec2660c9a9977b3b3a2eaed063b9049c0b07ff2
ToppCellLPS_IL1RA_TNF-Mesenchymal_myocytic-Myofibroblastic-Myofibroblast|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

ASPN FAT1 PZP PRUNE2 FLNA SLC4A7 CRYAB PLXNA4

5.60e-062002138dcdaec3ca3a3024dc1b8788c417003f84c2bffdc
ToppCellfacs-Aorta-Heart-3m-Epithelial-epithelial_cell|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ANO5 DNAJC6 ITIH4 DNAH6 NPAS1 ATP13A4 KMO

8.37e-0615121370de76acd1b204345dce7f33be2a1ed9fbe9e6da0
ToppCelldroplet-Liver-nan-3m-Epithelial-Hepatocyte_(Pericentral,_Midlobular,_Periportal)|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLCO1B3 BCHE ALDH1L1 ITIH1 ITIH2 ITIH4 PZP

8.37e-061512137cc9632b58522e2ba3ad36a0b8d37c7c9c8b636c4
ToppCellfacs-Aorta-Heart-3m-Epithelial-nan|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ANO5 DNAJC6 ITIH4 DNAH6 NPAS1 ATP13A4 KMO

8.37e-06151213720b9c8fb966c5d62ff909cc4a4616b109b78cdca
ToppCellfacs-Aorta-Heart-3m-Epithelial|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ANO5 DNAJC6 ITIH4 DNAH6 NPAS1 ATP13A4 KMO

8.37e-061512137bee48137d1f5f27a24571a59c835284651d38538
ToppCelldroplet-Liver-Hepatocytes-24m-Epithelial-Hepatocyte_(Pericentral_and_Periportal)|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLCO1B3 ALDH1L1 F5 ITIH1 ITIH2 ITIH4 PZP

9.52e-061542137a5289000597068ee8d559f89bce7bce31f35dd57
ToppCellCOVID-19-lung-Mesothelial|lung / Disease (COVID-19 only), tissue and cell type

DLGAP2 BCHE KCNA4 FGF9 ADAMTS3 SPTBN4 KCNH5

1.04e-051562137e1f563869b3bf997eaa2e756e31b53db1a478903
ToppCelldroplet-Liver-HEPATOCYTES-1m-Epithelial-nan|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLCO1B3 ALDH1L1 ITIH1 ITIH2 ITIH4 PZP KYAT1

1.12e-0515821379f58428f70d1427b20122c5c1cc7bf521d0f4832
ToppCelldroplet-Liver-HEPATOCYTES-1m-Epithelial|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLCO1B3 ITIH1 ITIH2 ITIH4 PZP PSAT1 KYAT1

1.67e-051682137b98af4043dfa5dfa4413e482879fad88de484675
ToppCelldroplet-Liver-HEPATOCYTES-1m-Epithelial-hepatocyte|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLCO1B3 ITIH1 ITIH2 ITIH4 PZP PSAT1 KYAT1

1.67e-051682137073b53d4cee6bc8c5c6fce51cf6cd9c316478f69
ToppCellwk_08-11-Mesenchymal-Chondrocyte-intermediate_chondrocyte|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

SHKBP1 PLCB1 SEMA6A LRRC63 PSAT1 CYP26B1 SYT16

1.95e-051722137415d57aa6278b8c12e7a2cf9c3fa5283389fb9b0
ToppCellPBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Myeloid-Granulocytic-Neutrophil|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)

CYBB NCF2 F5 PTGS2 SLIT2 SERPINA1 BEST1

1.95e-051722137c32e6af9e2d29da47b5d870207b598cff11aef6c
ToppCellPBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Myeloid-Granulocytic|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)

CYBB NCF2 F5 PTGS2 SLIT2 SERPINA1 BEST1

1.95e-0517221371a0556c97fcba126126c22adea5235d977d41ebe
ToppCellAdult-Endothelial-endothelial_cell_of_bronchial_vessel|Adult / Lineage, Cell type, age group and donor

ITGA6 ITGB4 PLCB1 SEMA6A PPM1F OR13A1 DCHS1

1.95e-051722137ad4ffdb3fc0c560a9cbaa2bc048476cbc43e8fd6
ToppCellCOVID-19-kidney-PCT-S3-2|kidney / Disease (COVID-19 only), tissue and cell type

SLCO1B3 ITIH1 ITIH2 ITIH4 ADH4 SERPINA1 PZP

2.10e-0517421375aa2fb631505600f37d2b87b02def7be139dc262
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

TMEM131L FLNA NIBAN1 OR51E2 SLCO5A1 WSCD2 RPE65

2.18e-051752137d52794426f2703a80e91ae0a8ff2d8e0ce4aa4a8
ToppCellE18.5-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1-AT1_prolif|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

TRPM6 ARSK PSAT1 CRYBG2 CRYAB USP10 ATM

2.18e-051752137711ace94fa9a763c6ae48171a690953f25deebe4
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

TMEM131L FLNA NIBAN1 OR51E2 SLCO5A1 WSCD2 RPE65

2.18e-051752137454f03e6109d65f5db08dbb41ecc19ffb6bbc4e0
ToppCellsystemic_lupus_erythematosus-flare-Lymphocytic_B-B_cell-male|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

BRAP FBXL18 BTD FAM157A DCLRE1A BAIAP3 CHD9

2.18e-05175213769ed3c7c45df6bef70f5f2ff003531160bf3b32b
ToppCellAdult-Endothelial-endothelial_cell_of_bronchial_vessel-D175|Adult / Lineage, Cell type, age group and donor

ITGA6 ITGB4 PLCB1 SEMA6A TBCD SESN3 OR13A1

2.34e-051772137c9f269765c7d5d29caab75910e51645606ed562e
ToppCellcellseq2-Mesenchymal-Fibroblastic-Fibroblastic_2-ASMC|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

ASPN BCHE KCNA4 PRUNE2 FLNA FSHR WSCD2

2.43e-0517821378ec2a25dda96c9cc9c2904b6cb18f75a293f4969
ToppCellcellseq2-Mesenchymal-Fibroblastic-Fibroblastic_2|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

ASPN BCHE KCNA4 PRUNE2 FLNA FSHR WSCD2

2.43e-0517821376c91331196696e0cf239d105f458e3230659fa38
ToppCellIIH-matDC-|IIH / Condition, Cell_class and T cell subcluster

BCL2L14 ASPN PTGFR TMEM150C FGF9 CRYAB SLCO5A1

2.52e-05179213746074b2781ed79e2979428b3ec81504621d3903c
ToppCellIIH-matDC|IIH / Condition, Cell_class and T cell subcluster

BCL2L14 ASPN PTGFR TMEM150C FGF9 CRYAB SLCO5A1

2.52e-0517921375999c85ce3bab5309ff1ed154be7e32b037750b1
ToppCelldroplet-Trachea-3m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l6-17|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

BCHE FPGT DNAJC6 PGM1 PXDN SH3TC1 LRRC63

2.61e-051802137455d1e3ccf2ab609954f3b870e8f514ddca735f4
ToppCellfacs-Lung-24m-Hematologic-myeloid-myeloid_dendritic_cell-dendritic_cell|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ARSK ANO5 RO60 ADAMTS3 PCDHB16 GLMN NUDCD1

2.61e-051802137d33bb00f2b7d07dda9015cb8eafd742c2b2e9ace
ToppCellE16.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-VSMC-VSMC_mature|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

DLGAP2 ASPN TRPV3 NIBAN1 ADAMTS2 CRYAB TRIM47

2.90e-051832137b4f29dd3994009bb5eb769d36d95886664e7f87d
ToppCellCOVID-19-Heart-CM_4|COVID-19 / Disease (COVID-19 only), tissue and cell type

ANO5 F5 PGM1 NIBAN1 CRYAB SLCO5A1 MYBPC3

2.90e-0518321372902b6e8aa9a6f62bc1a792c971ab7f651a8e676
ToppCellkidney_cells-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ALDH1L1 ACE USH2A SLC6A18 PRUNE2 CUBN LRP2

2.90e-051832137d73cac83cde82665f110baad7cf28db75f9ffe52
ToppCellLPS_only-Stromal_mesenchymal-Lung_smooth_muscle-Myofibroblast|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ASPN ITIH4 FAT1 PZP PRUNE2 CRYAB PLXNA4

3.11e-051852137e64e8c98dd88d91f6501d3fb10b60fd2f3c90af3
ToppCell(00)_Basal-(4)_1wkpi|(00)_Basal / shred by cell type and Timepoint

F5 ITGB4 PTGS2 ITIH4 FLNA CYP26B1 EPHA2

3.11e-051852137bf82ba905e5eee1c39a2731702071d3de10a78b8
ToppCellLPS-antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_3|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CSMD2 SLIT2 FAT1 NIBAN1 B4GALNT4 CRYAB RPE65

3.22e-0518621374780af76237d7af2abbe2d8d5530cdf53e3ed0b7
ToppCell356C-Endothelial_cells-Endothelial-E-|356C / Donor, Lineage, Cell class and subclass (all cells)

ITGA6 QRICH2 PXDN SEMA6A CUBN PCDHB16 OR51E2

3.22e-0518621372e024097ee361eeb1d855a4edb8ac8cdad35da06
ToppCell356C-Endothelial_cells-Endothelial-E|356C / Donor, Lineage, Cell class and subclass (all cells)

ITGA6 QRICH2 PXDN SEMA6A CUBN PCDHB16 OR51E2

3.22e-051862137c3449e54454009973818fc1101933c6f0168258c
ToppCellCOVID-19_Severe-Myeloid_G-Neutrophil|COVID-19_Severe / Disease group, lineage and cell class

NCF2 PTGS2 SERPINA1 FBXL18 NIBAN1 SMCHD1 PADI2

3.56e-051892137a62f4c445ede00d15b74bee65f4e4fb54cfd4d32
ToppCellPBMC-Severe-Myeloid-Neutrophil-Neutrophil|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

NCF2 PTGS2 SERPINA1 FBXL18 NIBAN1 SMCHD1 PADI2

3.56e-051892137f6b2b4824505f0119a017fdb73c55418fb651645
ToppCellLPS-IL1RA+antiTNF-Endothelial-Endothelial-Artery|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ITGA6 SLCO1B3 F5 ITGB4 PLCB1 CYP26B1 MMP28

3.56e-051892137c45734970036e6d28d5e3fe7c9458fae38a3f624
ToppCelldroplet-Lung-LUNG-1m-Mesenchymal-bronchial_smooth_muscle_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

BCHE ITIH4 TMEM150C PRUNE2 LGI3 WSCD2 MYBPC3

3.56e-0518921374dc32b463546bbe7250dddd281b92ad17ec22da1
ToppCellPBMC-Severe-Myeloid-Neutrophil-Neutrophil|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

NCF2 PTGS2 SERPINA1 FBXL18 NIBAN1 SMCHD1 PADI2

3.56e-051892137db8e314ce95c32542bb4015a77032a33211fea0b
ToppCelldroplet-Lung-LUNG-1m-Mesenchymal-Airway_Smooth_Muscle|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

BCHE ITIH4 TMEM150C PRUNE2 LGI3 WSCD2 MYBPC3

3.56e-0518921370d06bf0d7191d13a1c4f30a7881e7ea1093bfd6f
ToppCellfacs-Lung-3m-Endothelial-arterial_endothelial|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ACE ITGB4 SLC12A5 CASTOR1 PRUNE2 CYP26B1 TRIM47

3.81e-0519121376e6b2cb390cc5cd0356924a2c36fbe5b5bd5966c
ToppCell3'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-tracheobronchial_smooth_muscle_cell-Fibromyocytes|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ASPN BCHE ITIH1 PRUNE2 FLNA CRYAB PLXNA4

3.81e-0519121372a107e9096eb58b81b3da61547904d85754f6b2f
ToppCellLPS-antiTNF-Endothelial-Endothelial-Artery|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ITGA6 SLCO1B3 F5 ITGB4 PLCB1 CYP26B1 MMP28

3.81e-0519121374b3d5157344dbfbf4fab518611cd9fa37fac7bd9
ToppCellControl-Myeloid|Control / group, cell type (main and fine annotations)

CYBB HEXB ANO5 NCF2 SH3TC1 KMO SIGLEC1

3.81e-0519121379c4acc5f3c2f9c0c5520863bb22f391774372347
ToppCell10x_3'_v3-tissue-resident_(10x_3'_v3)-myeloid-myeloid_granulocytic-neutrophil|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

NCF2 F5 SHKBP1 SERPINA1 NIBAN1 PHC2 PADI2

3.81e-051912137b9b091d6b352d5128bb864ff52d2e5fb3387b766
ToppCell3'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-tracheobronchial_smooth_muscle_cell-Fibromyocytes-Fibromyocytes_L.2.3.2.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ASPN BCHE ITIH1 PRUNE2 FLNA CRYAB PLXNA4

3.81e-051912137d35692c652977500a3c36aa26c347a072b71e441
ToppCellfacs-Lung-3m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ACE ITGB4 SLC12A5 CASTOR1 PRUNE2 CYP26B1 TRIM47

3.81e-051912137482db995930346be69072ace2fd78fd453e97fb5
ToppCellNS-moderate-d_16-33-Myeloid-Neutrophil|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

NCF2 PTGS2 SERPINA1 BEST1 NIBAN1 SMCHD1 MIDN

3.94e-051922137545c3990cbe3c04bfd95a0ab7499d2c4af509be1
ToppCellLPS-antiTNF-Endothelial-Endothelial-Vein|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ITGA6 SLCO1B3 F5 ITGB4 PLCB1 SEMA6A MMP28

3.94e-05192213781baf1c4063469bb0c03a8602b40e387ba7b0dfb
ToppCellfacs-Lung-nan-3m-Endothelial-Capillary_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ITGA6 ACE PXDN PLCB1 SEMA6A CYP26B1 PPM1F

3.94e-0519221374bab9754cfd8b9c2d7cc1490e8a29f58c3c26f6c
ToppCellLPS-IL1RA+antiTNF-Stromal_mesenchymal-Lung_smooth_muscle|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ASPN FAT1 PLCB1 PZP PRUNE2 FLNA CRYAB

3.94e-051922137992d08092edbc68c47b945deb8708379738c239a
ToppCellLPS-IL1RA+antiTNF-Endothelial-Endothelial-Vein|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ITGA6 SLCO1B3 F5 ITGB4 PLCB1 SEMA6A MMP28

4.07e-0519321377261c1ce30c796b61c6ec58e64a051baa24732ff
ToppCellSmart-start-Cell-Wel_seq-Neoplastic-Stem-like-NPC-like-NPC-like_neural-F|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

CLASP2 CSMD2 BRAP ADH4 MMS22L SLCO5A1 PLXNA4

4.07e-051932137088c8b1e968f5356502347eaabdc6b1b1d4befd0
ToppCellmild-Myeloid-Neutrophils_1|mild / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

NCF2 PTGS2 SERPINA1 NIBAN1 SMCHD1 MIDN PADI2

4.20e-051942137ccd911ce3251cd1c60f1fb2ce00650fbe7a379bb
ToppCellcontrol-Lymphocytic-CD4_T_cells_2|Lymphocytic / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

NCF2 PTGS2 SHKBP1 SERPINA1 NIBAN1 PHC2 PADI2

4.20e-051942137c2ae2ea848d78725455dcb6be9f1d8933745fa80
ToppCelldistal-Hematologic-Myeloid_Dendritic_Type_1-1|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

BCL2L14 ITIH1 GPR132 SLC5A3 SLCO5A1 CD1C N4BP2

4.20e-051942137f0467d81063a9b19783906c456935ef8318b9b98
ToppCell5'-GW_trimst-2-SmallIntestine-Mesenchymal-myocytic-SMC_(PART1/CAPN3+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ASPN BCHE PRUNE2 FLNA NIBAN1 MMP28 CRYAB

4.20e-051942137d2bafd31bb8333f66b6c714944bceb2f1aa11740
ToppCelldistal-1-Hematologic-Myeloid_Dendritic_Type_1|1 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

BCL2L14 ITIH1 GPR132 SLC5A3 SLCO5A1 CD1C N4BP2

4.20e-05194213785a4be291c25ad1fb14199b87d822cf47d748fc0
ToppCellmild-Myeloid-Neutrophils_3|mild / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

NCF2 PTGS2 SERPINA1 NIBAN1 PHC2 USP10 PADI2

4.34e-051952137a1cfed0092debcc003eff6a62508556b7664d5e1
ToppCellsevere-Classical_Monocyte|World / disease stage, cell group and cell class

CYBB OTUD1 NCF2 PTGS2 SERPINA1 ADAMTS2 PHC2

4.34e-051952137cf638aac4d57ae0774008920a1a5e9dfd8c73885
ToppCellsaliva-Mild-Moderate_progression_d12-25-Myeloid-Granulocytic-Neutrophil|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

NCF2 PTGS2 SERPINA1 FLNA BEST1 NIBAN1 SMCHD1

4.49e-051962137fe8d3f45a64323947c36b127355d5940eb56c0ca
ToppCellMid-temporal_gyrus_(MTG)-Neuronal|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

DLGAP2 SLC12A5 KCNH1 PLCB1 PAK5 SPTBN4 SYT16

4.49e-051962137676c56b44ac29f7baecb62f49bb8597cc74c0a88
DiseaseADP-ribosylation factor-like protein 11 measurement

BCHE RSU1 CUBN

1.26e-0642023EFO_0801355
DiseaseConventional (Clear Cell) Renal Cell Carcinoma

BCHE FPGT PTGS2 HNF1A SLC5A3 CRYAB SPTBN4 ATM

8.72e-061482028C0279702
DiseaseColonic Neoplasms

SLCO1B3 MCM2 F5 PTGS2 ITIH4 MKI67 PLCB1 CRYAB

1.06e-051522028C0009375
DiseaseMalignant tumor of colon

SLCO1B3 MCM2 F5 PTGS2 ITIH4 MKI67 PLCB1 CRYAB

1.47e-051592028C0007102
Diseasemitral valve prolapse (is_implicated_in)

ACE FLNA DCHS1

2.58e-0592023DOID:988 (is_implicated_in)
DiseaseColorectal Carcinoma

SLCO1B3 ALDH1L1 F5 PTGS2 PGM1 SLC12A5 FAT1 SH3TC1 MKI67 PZP CAD STAM CUBN PPM1F DCHS1 LRP2

2.96e-0570220216C0009402
DiseaseRenal Cell Carcinoma

BCHE FPGT PTGS2 HNF1A SLC5A3 CRYAB SPTBN4

2.98e-051282027C0007134
DiseaseSarcomatoid Renal Cell Carcinoma

BCHE FPGT PTGS2 HNF1A SLC5A3 CRYAB SPTBN4

2.98e-051282027C1266043
DiseaseChromophobe Renal Cell Carcinoma

BCHE FPGT PTGS2 HNF1A SLC5A3 CRYAB SPTBN4

2.98e-051282027C1266042
DiseaseCollecting Duct Carcinoma of the Kidney

BCHE FPGT PTGS2 HNF1A SLC5A3 CRYAB SPTBN4

2.98e-051282027C1266044
DiseasePapillary Renal Cell Carcinoma

BCHE FPGT PTGS2 HNF1A SLC5A3 CRYAB SPTBN4

2.98e-051282027C1306837
Diseasetransmembrane protein 119 measurement

RSU1 CUBN

4.66e-0522022EFO_0803182
Diseasearylamine N-acetyltransferase 1 measurement

ITIH1 ITIH2

4.66e-0522022EFO_0801394
Diseasesodium channel subunit beta-2 measurement

ITIH1 ITIH2

4.66e-0522022EFO_0803085
Diseaseprimary hyperaldosteronism (biomarker_via_orthology)

CYBB SERPINA1

4.66e-0522022DOID:446 (biomarker_via_orthology)
Diseasejunctional epidermolysis bullosa with pyloric atresia (is_implicated_in)

ITGA6 ITGB4

4.66e-0522022DOID:0060733 (is_implicated_in)
DiseaseLiver carcinoma

MCM2 ACE DNAJC6 PTGS2 ADH4 SLIT2 SERPINA1 FBXL18 MKI67 MICA PZP HNF1A ATM

5.18e-0550720213C2239176
DiseaseAdenocarcinoma of lung (disorder)

TRPM6 GART MAP3K15 PSAT1 SLC4A7 PAK5 ROS1 ATM

9.26e-052062028C0152013
Diseasechildhood trauma measurement, alcohol consumption measurement

DLGAP2 ITGA6 PCDHGA4 PCDHGA12 PCDHGA8

1.29e-04712025EFO_0007878, EFO_0007979
DiseaseProteinuria

SMG6 CUBN LRP2

1.35e-04152023HP_0000093
DiseaseEpidermolysis bullosa with pyloric atresia

ITGA6 ITGB4

1.39e-0432022C1856934
Diseasejanus kinase and microtubule-interacting protein 3 measurement

ITIH1 SERPINA1

1.39e-0432022EFO_0801738
DiseasePolyposis, Adenomatous Intestinal

F5 PTGS2 ITIH4

1.66e-04162023C2713442
DiseaseFamilial Intestinal Polyposis

F5 PTGS2 ITIH4

1.66e-04162023C2713443
Diseasecolorectal cancer (is_implicated_in)

FAT1 MKI67 TRPV3 HNF1A XPO1 ATM

1.91e-041212026DOID:9256 (is_implicated_in)
DiseaseAdenomatous Polyposis Coli

F5 PTGS2 ITIH4

2.00e-04172023C0032580
Diseaseliver cirrhosis (is_implicated_in)

ACE F5 PTGS2 SERPINA1

2.13e-04432024DOID:5082 (is_implicated_in)
Diseaseasporin measurement

ASPN SERPINA1

2.77e-0442022EFO_0801397
Diseaserenal fibrosis (is_marker_for)

CYBB ACE

2.77e-0442022DOID:0050855 (is_marker_for)
Diseaserho-related GTP-binding protein Rho6 measurement

BCHE SERPINA1

2.77e-0442022EFO_0803022
Diseasecognitive inhibition measurement

TRPM6 USH2A PHC1 WSCD2

3.84e-04502024EFO_0007969
Diseasesusceptibility to plantar warts measurement

A3GALT2 PTGS2 CFAP47 PHC2 N4BP2

3.92e-04902025EFO_0008406
Diseaseneuroimaging measurement

BCL2L14 NBEAL1 PGM1 SLIT2 SERPINA1 ZNF469 CASTOR1 SMG6 ADAMTS3 SNX24 SZT2 PAK5 ZDHHC5 XPO1 STAM ZBTB32 FSHR TRIM47

4.28e-04106920218EFO_0004346
Diseasenon-arteritic anterior ischemic optic neuropathy (is_implicated_in)

ACE F5

4.60e-0452022DOID:0050864 (is_implicated_in)
DiseaseChronic granulomatous disease

CYBB NCF2

4.60e-0452022cv:C0018203
Diseasesingle Ig IL-1-related receptor measurement

ITIH1 ITIH2

4.60e-0452022EFO_0802072
Diseaseaspartate aminotransferase measurement

SLCO1B3 ANO5 BIRC6 ITIH1 ADH4 SERPINA1 SH3TC1 FGF9 RAB2A SMG6 HNF1A SLC4A7 STAM CUBN IPO9 MYBPC3

5.27e-0490420216EFO_0004736
Diseasenephrotic syndrome (implicated_via_orthology)

ACE PTGS2 FAT1

5.75e-04242023DOID:1184 (implicated_via_orthology)
Diseasepre-eclampsia (is_implicated_in)

ACE F5 HNF1A

6.51e-04252023DOID:10591 (is_implicated_in)
DiseaseEye Diseases, Hereditary

LRP2 RPE65

6.87e-0462022C0015398
Diseaseanxiety measurement

ITIH4 ASCC3 MMS22L ZDHHC5 WSCD2

9.01e-041082025EFO_0009863
Diseasereticulocyte count

BIRC6 GGCX BRAP SLC12A5 SERPINA1 ZNF469 FAT1 KCNA4 FBXL18 PLCB1 TMEM131L BAIAP3 SMG6 MMP28 OR6P1 USP10 NISCH

9.04e-04104520217EFO_0007986
Diseaseepilepsy (implicated_via_orthology)

ITGA6 SLC12A5 KCNK18 KCNA4 KCNH1 KCNH5

9.31e-041632026DOID:1826 (implicated_via_orthology)
Diseasejunctional epidermolysis bullosa (is_implicated_in)

ITGA6 ITGB4

9.57e-0472022DOID:3209 (is_implicated_in)
Diseaseinter-alpha-trypsin inhibitor heavy chain H1 measurement

ITIH1 ITIH2

9.57e-0472022EFO_0801705
Diseasereticulocyte measurement

BIRC6 BRAP SERPINA1 ZNF469 FAT1 KCNA4 PLCB1 TMEM131L MICA BAIAP3 SMG6 FLNA MMP28 ECPAS USP10 NISCH SIGLEC1

9.82e-04105320217EFO_0010700
Diseasecerebral infarction (is_implicated_in)

ACE F5 HNF1A

1.01e-03292023DOID:3526 (is_implicated_in)
Diseaseuric acid measurement

SPNS1 BIRC6 F5 QRICH2 BRAP CASTOR1 HNF1A FRAS1 ZDHHC5 CUBN GLMN LRP2

1.08e-0361020212EFO_0004761
DiseaseSchizophrenia

CDK16 DLGAP2 CSMD2 ACE PTGS2 ITIH1 BRAP SLC12A5 PLCB1 NPAS1 PSAT1 ADAMTS3 KMO LRP2 ATM

1.18e-0388320215C0036341
Diseaseceramide measurement

HAPLN4 SLCO1B3 HNF1A PHC1 SLCO5A1 ZBTB32 PLXNA4

1.23e-032352027EFO_0010222
DiseaseBenign Neoplasm

BIRC6 PTGS2 EPHA2 ATM

1.23e-03682024C0086692
DiseaseNeoplasms

BIRC6 PTGS2 EPHA2 ATM

1.23e-03682024C0027651
DiseaseAdenocarcinoma

ACE PTGS2 SERPINA1 MKI67 FGF9

1.24e-031162025C0001418
DiseaseCarcinoma, Granular Cell

ACE PTGS2 SERPINA1 MKI67 FGF9

1.24e-031162025C0205644
DiseaseAdenocarcinoma, Tubular

ACE PTGS2 SERPINA1 MKI67 FGF9

1.24e-031162025C0205645
DiseaseAdenocarcinoma, Oxyphilic

ACE PTGS2 SERPINA1 MKI67 FGF9

1.24e-031162025C0205642
DiseaseCarcinoma, Cribriform

ACE PTGS2 SERPINA1 MKI67 FGF9

1.24e-031162025C0205643
DiseaseAdenocarcinoma, Basal Cell

ACE PTGS2 SERPINA1 MKI67 FGF9

1.24e-031162025C0205641
DiseasePure Gonadal Dysgenesis, 46, XX

POLR3H FSHR

1.27e-0382022C0685837
DiseasePosterior subcapsular cataract

CRYAB EPHA2

1.27e-0382022C0858617
Diseasekallistatin measurement

SERPINA1 SERPINA9

1.27e-0382022EFO_0008196
DiseaseGonadal Dysgenesis, 46,XX

POLR3H FSHR

1.27e-0382022C0949595
Diseasesarcoidosis (is_marker_for)

ACE PTGS2

1.27e-0382022DOID:11335 (is_marker_for)
Diseasechemokine (C-C motif) ligand 27 measurement

SLCO1B3 F5 ITIH1 SLC4A7

1.37e-03702024EFO_0008082
Diseaset-tau measurement

BCL2L14 DLGAP2 F5 FSHR PLXNA4

1.79e-031262025EFO_0004760
Diseasemean platelet volume

ITGA6 SHKBP1 ADH4 FBXL18 BTD PLCB1 TMEM131L MICA TBCD NIBAN1 SNX24 PCDHGA4 CHD9 PCDHGA12 PCDHGA8 MYBPC3

1.85e-03102020216EFO_0004584
Diseaseaxin-2 measurement

BCHE ITIH1

2.02e-03102022EFO_0801400
DiseaseMalignant neoplasm of tongue

PTGS2 CRYAB

2.02e-03102022C0153349
DiseaseTongue Neoplasms

PTGS2 CRYAB

2.02e-03102022C0040411
Diseaselevel of Phosphatidylcholine (18:0_22:5) in blood serum

BEST1 HNF1A

2.02e-03102022OBA_2045096
Diseasethiamine measurement

ANO5 N4BP2

2.02e-03102022EFO_0010540
DiseaseReactive hypoglycemia

SERPINA1 HNF1A

2.02e-03102022C0271710
DiseaseFasting Hypoglycemia

SERPINA1 HNF1A

2.02e-03102022C0271708
Diseasememory performance

DLGAP2 F5 ITIH1 ITIH4 PXDN ALS2 PCDHB16 N4BP2 ZNF335

2.14e-034092029EFO_0004874
DiseaseDepression, Bipolar

ITIH1 SERPINA1 KMO SLC5A3

2.15e-03792024C0005587
Diseasealcohol consumption measurement

DLGAP2 POLR3H BIRC6 ADH4 SERPINA1 PLCB1 XYLB HNF1A MMS22L CAD DPP3 PHC2 OR51E2 IPO9 PLXNA4 WSCD2 HAS3 MYBPC3

2.31e-03124220218EFO_0007878
Diseasecortical surface area measurement

TRPM6 HEXB NBEAL1 HAPLN4 PGM1 EVI5 SLIT2 SERPINA1 ZNF469 MICA SEMA6A SMG6 ADAMTS3 XPO1 PHC2 FSHR WSCD2 MPHOSPH9 HAS3

2.34e-03134520219EFO_0010736
DiseaseNeurodegenerative Disorders

SERPINA1 TBCD CRYAB

2.41e-03392023C0524851
DiseaseDegenerative Diseases, Central Nervous System

SERPINA1 TBCD CRYAB

2.41e-03392023C0270715
DiseaseDegenerative Diseases, Spinal Cord

SERPINA1 TBCD CRYAB

2.41e-03392023C0751733
Diseasegranulosa cell tumor (is_marker_for)

PTGS2 FSHR

2.46e-03112022DOID:2999 (is_marker_for)
DiseaseHypoglycemia

SERPINA1 HNF1A

2.46e-03112022C0020615
DiseaseBarrett's esophagus (is_marker_for)

PTGS2 MKI67

2.46e-03112022DOID:9206 (is_marker_for)
Diseaseamino acid measurement

MOXD2P DLGAP2 ZFYVE16 PTGFR OR8B3 SLIT2 PXDN PHC2 OR51E2 NISCH LRP2 OR2D2

2.60e-0367820212EFO_0005134
DiseaseLiver Cirrhosis, Experimental

CYBB ZFYVE16 ASPN ALDH1L1 PTGS2 ADH4 FAT1 PXDN MKI67 PRUNE2 FLNA KMO CRYAB

2.74e-0377420213C0023893
Diseaseage at menarche

DLGAP2 DNAJC6 PLCB1 XYLB ASCC3 ECPAS VAC14 ZBTB32 PPM1F WSCD2 MMD

2.76e-0359420211EFO_0004703
Diseaseosteoarthritis, knee, body mass index

SMG6 B4GALNT4 WSCD2

2.78e-03412023EFO_0004340, EFO_0004616
Diseasepsoriasis

ZFYVE16 GART BRAP BTD MICA PAK5 GLMN

2.86e-032732027EFO_0000676
DiseaseMouth Diseases

PTGS2 CYP26B1

2.94e-03122022C0026636
DiseaseStuttering

PLCB1 HNF1A PSAT1 KYAT1 SYT16

3.10e-031432025HP_0025268
DiseaseKidney Diseases

CYBB ACE PTGS2 LRP2

3.18e-03882024C0022658
Diseaseresponse to methotrexate, serum alanine aminotransferase measurement

ITGA6 PGM1 ECPAS

3.19e-03432023EFO_0004735, GO_0031427
Diseaseschizophrenia (is_marker_for)

BCHE ACE KMO

3.41e-03442023DOID:5419 (is_marker_for)
DiseaseT-cell surface glycoprotein CD3 epsilon chain measurement

BCHE F5

3.46e-03132022EFO_0802114
Diseasebilirubin measurement

SLCO1B3 BIRC6 SHKBP1 ADH4 SERPINA1 KCNA4 MIPEP SMG6 HNF1A

3.57e-034422029EFO_0004570
Diseasethyroid peroxidase antibody measurement, anti-thyroglobulin antibody measurement

TRPM6 SMG6 FSHR

3.63e-03452023EFO_0005666, EFO_0009896
DiseaseGastric Adenocarcinoma

EPHA2 ROS1 ATM

3.63e-03452023C0278701
Diseaseresponse to angiotensin-converting enzyme inhibitor, Cough

NIBAN1 CYP26B1 VPS13B

3.86e-03462023EFO_0005325, HP_0012735
DiseaseSeizures

HEXB BCHE PTGS2 SLC12A5 CLPB TBCD

4.01e-032182026C0036572
Diseaserenal cell carcinoma (biomarker_via_orthology)

PTGS2 CAD

4.02e-03142022DOID:4450 (biomarker_via_orthology)

Protein segments in the cluster

PeptideGeneStartEntry
SFDGRLTFHPGSQVV

ARSK

41

Q6UWY0
LFLVPDTNGFIDHLA

SMG6

1246

Q86US8
ISFFSGNPSVEIVHG

BRAP

126

Q7Z569
FPGVSEFGKESILFH

BCHE

386

P06276
EQDHDLESFGPLGLF

ANO5

656

Q75V66
NAEGIHNFAPLGTIT

BIRC6

3156

Q9NR09
PVGFGAHIQFLNFST

CSMD2

2001

Q7Z408
VSIGTEVTPFQEHFG

CRYBG3

1116

Q68DQ2
NPGFHEAIGDVLALS

ACE

1011

P12821
SFFHAEGQGLPLESL

BAIAP3

956

O94812
TLESLEFIPQHVGAF

ALS2

1346

Q96Q42
SKFEGLAFPVIVGHE

ADH4

56

P08319
FNFDHALVPEDGIGS

CASTOR1

301

Q8WTX7
EGIAILHQFPFSSAL

ATP13A4

591

Q4VNC1
FNLTEIPEAQIHEGF

SERPINA1

106

P01009
LDHGGEFIPVTSLQS

GSDMD

16

P57764
GFHLEIFPNGTIQGT

FGF9

71

P31371
FLRESGIDPSQVGVH

APBA3

356

O96018
FVTEGLSFQLQGHVP

BCL2L14

181

Q9BZR8
VQADLELEGFPGHIT

DLGAP2

776

Q9P1A6
TIEHVFNIIGAFDIP

POLE2

81

P56282
GHELDLVVPVFTFLQ

BEST1

266

O76090
EPGHTGEFLLRVFTD

CAPN5

476

O15484
GIEPGAFEGVTVFHI

ASPN

211

Q9BXN1
DHAIFLTRQDFGPSG

ADAMTS2

361

O95450
IHIFEPQGISFLETE

ITIH4

176

Q14624
VLFPLLEQISHFSEG

NBEAL1

876

Q6ZS30
ILGKHGFFVNPSDSV

PGM1

296

P36871
FQPVHDLTIGVEFGA

RAB2A

31

P61019
GGRIQHPFTVEEFVL

PZP

211

P20742
FQPVHDLTIGVEFGA

RAB2B

31

Q8WUD1
ATGFIQPGTEQHDLI

QRICH2

391

Q9H0J4
AHLEDFQGLTIPQGS

RIMBP3B

1541

A6NNM3
QFFGEHLLESDLFPT

CRYAB

26

P02511
PASHFVGVEEVQAFL

PCDHGA8

736

Q9Y5G5
PASHFVGVDGVQAFL

PCDHGA12

736

O60330
IPLHQTDLSVGFDTG

KCNJ9

221

Q92806
FNEELGDPFIIIHSI

NUDCD1

156

Q96RS6
PAALVSEVFEQHLGG

NPAS1

126

Q99742
LTNLGDVHVFSVPGL

LLGL1

881

Q15334
GFPVFATVILANHVA

MCM2

431

P49736
VQSGFLTEVHLDGQP

MICA

41

Q29983
TLQSEGHIREFPVFG

EXO5

156

Q9H790
VHTGFDPQEQKFTGL

PAK5

21

Q9P286
VPASHFVGVDGVRAF

PCDHGA4

766

Q9Y5G9
TGDAFDINPHSGTII

FAT1

1706

Q14517
FGSAHLSLEVPEGQD

DCHS1

1751

Q96JQ0
LDHFSPLIEGDVGEF

OTUD1

351

Q5VV17
LTTIGFGDTVLEHPN

KCNK18

321

Q7Z418
FVLTPDHLGGIEFDL

FRAS1

3561

Q86XX4
EGEAHRVLFGFVPET

NCF2

241

P19878
LGQFFHPIGFEVSDI

ITIH1

831

P19827
FFLSEVSGFEIPING

ITIH2

11

P19823
IGFLSQLPHGLIESF

GTPBP6

351

O43824
IGHLSELPSVNIGAF

MMS22L

181

Q6ZRQ5
VESVHGDFLNVVGFP

ASMTL

186

O95671
HPVDGLSVKFFGLDS

CYP26B1

481

Q9NR63
DIVLNFHTTFVGPGG

KCNH5

261

Q8NCM2
PEIQHGSLLALGFTV

ECPAS

746

Q5VYK3
DALFGHQFPSEETTG

GPATCH8

1186

Q9UKJ3
SGLVITDFFGHLING

PTGFR

71

P43088
LFIPGSVESQRVGDH

PCNX4

851

Q63HM2
VTFRGEPAEGFNHLV

PLXNA4

41

Q9HCM2
HEGRVNLVFFIGSPT

FAM157A

351

C9JC47
FTHATFVLIGIPGLE

OR51E2

6

Q9H255
IDNSLQETGVGFPLH

EVI5

746

O60447
DVSISPGEFEHNFLG

MPHOSPH9

111

Q99550
VLNFHTTFVGPAGEV

KCNH1

266

O95259
PEHLRFAVGQEVFGL

PTGS2

266

P35354
HPQVLEIFGFEGADA

DPP3

521

Q9NY33
QFTHAGQGGLIEEPT

HNF1A

176

P20823
IPHPFGVSLFEGQVF

LRP2

601

P98164
KLTVDGNELSFFPHG

LRRC63

441

Q05C16
FSNHVGLGPIESIGN

MED17

551

Q9NVC6
LPEHIFDGEGLASSF

ITGA6

341

P23229
GFKELFQTPGHTEEL

MKI67

1226

P46013
LTGFKELFQTPGHTE

MKI67

1346

P46013
GFKELFQTPGHTEES

MKI67

1956

P46013
DLVGFKELFQTPGHT

MKI67

2436

P46013
CFPDEGFSGLVSIHV

PADI2

256

Q9Y2J8
EFILAGLTDHPEFQQ

OR8B3

11

Q8NGG8
TEPFLVDGLTLGAQH

ITGB4

1771

P16144
GVVFFKSDGIIPFAH

MMD

191

Q15546
GLSDGPHTEQLLFIV

OR2D2

16

Q9H210
DFFLLGIFSQISHPG

OR2T10

11

Q8NGZ9
QEVGVLTGPDRHTFL

PFN3

46

P60673
ATLHVLLVDGFSQPF

PCDHB16

656

Q9NRJ7
LGFGNITTVLDDHTP

OTOP1

236

Q7RTM1
GGHVEEFVLVGFPTT

OR6P1

6

Q8NGX9
SGLTIAVHFEQPFQI

CUBN

2126

O60494
FGSEHPGSKQEFLSL

G2E3

401

Q7L622
GPFSLLEEINHFLSV

ATM

1586

Q13315
DHAIFLTRQDFGPAG

ADAMTS3

351

O15072
QEGLLPHFDESTFGQ

CHD9

411

Q3L8U1
ESFPVFHGLTQNILS

DNAH6

3426

Q9C0G6
LLGDAAHAIVPFFGQ

KMO

301

O15229
GIPEKFHGTDFDTVF

CABP7

106

Q86V35
ELHSGKSPEGFFQVA

CD1C

121

P29017
FQGLSLVSHAPGEAL

ANKZF1

26

Q9H8Y5
LFPGSTVEEQLHFIF

CDK16

361

Q00536
FEGTGFSNIPQLIDH

FER

516

P16591
GLHEGHTFEPAEFII

FLNA

2056

P21333
VHEFQTLSPEGSGNL

EPHA2

521

P29317
PEGLEVLHFSSGQIE

CENPJ

1221

Q9HC77
GDQHILSEGEFPTLT

CRYBG2

1406

Q8N1P7
FQLQFHTGFIPLDTT

DNAJC6

321

O75061
PQLVDHSVLLVGFGS

CTSW

286

P56202
DQHFSGTFGPEALAE

A3GALT2

201

U3KPV4
QIIVFPEDGIHGFNF

BTD

106

P43251
PEDGIHGFNFTRTSI

BTD

111

P43251
LGFVDAGIIFVIHSP

ASIC5

246

Q9NY37
EAFEHTPGIQTASLG

G6PC2

191

Q9NQR9
ISNSESGPRGVHFIF

CYBB

551

P04839
FGVHLAELTVDPQGA

IPO9

56

Q96P70
TDVFVALGPQHRAFG

HAPLN4

96

Q86UW8
EEHPLVFLFLGSSGI

CLPB

371

Q9H078
FHEVLGGTEQAGFFV

HAS3

136

O00219
AQGFSPVIQGHTDEL

EML3

586

Q32P44
GFLKTDGSFVVHDIP

EMC7

76

Q9NPA0
NGTVILHTGDFRADP

DCLRE1A

806

Q6PJP8
NDVFHGASGPVILDI

FSHR

211

P23945
SEVFPDQFIHLGGDE

HEXB

341

P07686
GGPTKFEIHIVAQFD

SEH1L

261

Q96EE3
QGFSSPEEGEFILHV

CFAP47

921

Q6ZTR5
PEEGEFILHVFQGNA

CFAP47

926

Q6ZTR5
LHFFINGIDQGVATP

NEURL4

446

Q96JN8
TIGTTHGVFVLDPFD

FPGT

211

O14772
TLGAFGHEEEVISNP

PHKB

811

Q93100
GFFDVVPHQEVVGLV

PPM1F

361

P49593
LVTEFILQGFSEHPE

OR13A1

26

Q8NGR1
ISRDGIVPFLQVFGH

SLC12A5

536

Q9H2X9
GSVLEGTFLENHPQA

SLC12A5

731

Q9H2X9
DTDVLQLGFFTFPIH

MOXD2P

336

A6NHM9
TGPADIRLTFFQGDH

MMP28

176

Q9H239
LTQLFVEHFFGGVGI

OR4C6

96

Q8NH72
VGFAIPLSIIAFTNH

GPR132

206

Q9UNW8
AHLTSVPFGELDFGE

MAP3K15

96

Q6ZN16
GAVIESFVNHAPGVF

MIDN

266

Q504T8
LQDSIHVVINGFFPG

ORC2

331

Q13416
ASEIIGFLSAIGHPF

GLMN

241

Q92990
PIADQFQLGVSHVFE

RSU1

221

Q15404
GKEQELFFFHELSPG

TARS2

306

Q9BW92
IFEQHLGSEPEIFGP

SZT2

2576

Q5T011
LNDGSVTPLAFSVGH

USH2A

3811

O75445
GAVLPHFNVLFDGLS

VAC14

126

Q08AM6
VTEELLFELFHQAGP

RBM7

21

Q9Y580
AEVEINIPVTFHGLF

RPE65

516

Q16518
PAFFLESVDAHLQIG

TRIM47

611

Q96LD4
DTVHLPFEGGSLLQI

SLC4A7

1166

Q9Y6M7
NLGVFSVFAPRGEHT

SMCHD1

1326

A6NHR9
IFIGTGEHIDDFEPF

SRP54

271

P61011
GTFVPDILHGNFQEG

PRUNE2

2046

Q8WUY3
HGFDSQLPGTLETVN

SYT16

156

Q17RD7
SVLDFGIQFLGHPVA

TMEM131L

96

A2VDJ0
SSGPELFSIHFNGQV

F5

261

P12259
AHLEDFQGLTIPQGS

RIMBP3

1541

Q9UFD9
NLHAFLISVPGSFAE

FBXL18

261

Q96ME1
SEHDVVNLGQGFPDF

KYAT1

26

Q16773
TVHGVEFDFIPDVKG

PSAT1

156

Q9Y617
PAFSTQGEFHEETGL

SLCO5A1

796

Q9H2Y9
IGVFHLGVPVEALFF

SHKBP1

281

Q8TBC3
FVSNIGSEHFIGLAG

SLC5A3

56

P53794
THESLLIQEGPFFVL

SH3TC1

201

Q8TE82
GVHVSLGFFDDILIP

POLR3H

96

Q9Y535
LGEFGVRNVHTTDFP

POLR1C

16

O15160
EEIHNVGTSLTFGFG

TMEM150C

126

B9EJG8
ISPFTAVNDLGHLLG

NDUFAF5

216

Q5TEU4
SLLDIHGEFQETPVG

SANBR

91

Q6NSI8
VFTDNETFAGGVHPA

RO60

466

P10155
QGLGFNLTHTPESAI

SERPINA9

96

Q86WD7
FEGIPIFHVELAIGQ

SLC6A18

66

Q96N87
GPGLAFVVFTETDLH

SLC6A18

381

Q96N87
GFIHPARDGDVQFSV

B4GALNT4

171

Q76KP1
PHQLFIGGEFVDAEG

ALDH1L1

421

O75891
PQFDKFGEGIIITTH

ASCC3

856

Q8N3C0
FDHGAEAIVPTLFNL

CLASP2

171

O75122
GEGEVTDFLRLPHFT

SUPT6H

801

Q7KZ85
VQLGFDLDAHGIIFT

STK19

201

P49842
LGGHITAEIPQIFDA

XPO1

811

O14980
HVIEGFVIQEGAEPF

PHC2

571

Q8IXK0
FIADFPGLHLENFVS

GGCX

531

P38435
PTDTFGTINFQDGEH

TRPM6

91

Q9BX84
FGVPELSAPEGFHIA

MIPEP

66

Q99797
VFTFEQLLSPHLQGE

NIBAN1

451

Q9BZQ8
ASDFPNVVIEGVLHG

SNX24

146

Q9Y343
HALASFVFGSGINPE

SESN3

201

P58005
TLLHFAGAGFPEDSE

SEMA6A

11

Q9H2E6
FQIVLSHLLGDAGSP

SPNS1

421

Q9H2V7
TQDFLPVQGIEDSFH

ZNF721

6

Q8TF20
LEFLNNGEHFVPSAG

SLCO1B3

671

Q9NPD5
LTDFGIAVFEIPHQE

NISCH

731

Q9Y2I1
FHISPEGFLTINDVG

PXDN

571

Q92626
SVHFDRDLPEFGTQG

XYLB

36

O75191
GVHPLDSFTQGFGEQ

ZNF768

191

Q9H5H4
NQFILELFHGPTGSF

THNSL1

336

Q8IYQ7
GSPELGQDFEHVSVL

SPTBN4

1751

Q9H254
ETHQGIGLFPSNFVT

STAM

251

Q92783
GVLFHVNKSGFPIDS

VASH2

46

Q86V25
HIIEGFVIQEGAEPF

PHC1

736

P78364
HIEEFGFGNLVIFGS

ROS1

536

P08922
SLHGNDISVVPEGAF

SLIT2

831

O94813
FNSQKFEPTGVGHLE

SIGLEC1

186

Q9BZZ2
TKHFPGEFGSEILVQ

VCPIP1

631

Q96JH7
HFDPFTEGIVDGIVA

PLCB1

661

Q9NQ66
GFPEAQALGLEVFHA

GART

356

P22102
EGIVHNSLPFFSVQF

CAD

321

P27708
DVAGHAFTNGPLVFA

ZNF469

291

Q96JG9
FFIPVAGLTGFHVVL

ZDHHC5

196

Q9C0B5
FVDTEIRLGAFPGHQ

VPS13B

3071

Q7Z7G8
DFVQTPITGIFGGHI

USP10

596

Q14694
AHFFLEIEGFEPNPT

TRPV3

41

Q8NET8
QGTFPHGIDILTTAD

TBCD

521

Q9BTW9
GSQEFPAHSLVLAGV

ZBTB32

36

Q9Y2Y4
SLVFLHSGFVGQPAV

WSCD2

31

Q2TBF2
QGLFGTDETVPEHIQ

ZNF335

1311

Q9H4Z2
PGPDTLQFTVDVFHF

ZP3

256

P21754
EHNLQLFVPSTIGAF

TDH

156

Q8IZJ6
SKDHGGFLFITPTFQ

ZFYVE16

1146

Q7Z3T8
NSGHTIFNDPFFIVE

KCNA4

361

P22459
FSEIQDGAFSHLPLL

LGI3

76

Q8N145
DLFQGNHGFVAPVVT

N4BP2

371

Q86UW6
LFELHITDAQPAFTG

MYBPC3

221

Q14896