Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	C-type_lectin_CS	VCAN CLEC4G CLEC3B	2.74e-04	43	55	3	IPR018378
Domain	C_TYPE_LECTIN_1	VCAN CLEC4G CLEC3B	1.69e-03	80	55	3	PS00615
Domain	H2B	H2BC20P H2BC19P	1.72e-03	21	55	2	SM00427
Domain	HISTONE_H2B	H2BC20P H2BC19P	1.72e-03	21	55	2	PS00357
Domain	Histone_H2B	H2BC20P H2BC19P	1.72e-03	21	55	2	IPR000558
Domain	Lectin_C	VCAN CLEC4G CLEC3B	1.95e-03	84	55	3	PF00059
Domain	CLECT	VCAN CLEC4G CLEC3B	1.95e-03	84	55	3	SM00034
Domain	C_TYPE_LECTIN_2	VCAN CLEC4G CLEC3B	2.01e-03	85	55	3	PS50041
Domain	C-type_lectin-like	VCAN CLEC4G CLEC3B	2.08e-03	86	55	3	IPR001304
Domain	EGF_Ca-bd_CS	HMCN2 VCAN JAG1	2.93e-03	97	55	3	IPR018097
Domain	-	VCAN CLEC4G CLEC3B	2.93e-03	97	55	3	3.10.100.10
Domain	C-type_lectin-like/link	VCAN CLEC4G CLEC3B	3.10e-03	99	55	3	IPR016186
Domain	EGF_CA	HMCN2 VCAN JAG1	3.10e-03	99	55	3	PS01187
Domain	ASX_HYDROXYL	HMCN2 VCAN JAG1	3.19e-03	100	55	3	PS00010
Domain	EGF-type_Asp/Asn_hydroxyl_site	HMCN2 VCAN JAG1	3.76e-03	106	55	3	IPR000152
Domain	CTDL_fold	VCAN CLEC4G CLEC3B	3.86e-03	107	55	3	IPR016187
Domain	Myb_DNA-binding	TADA2A MYB	4.76e-03	35	55	2	PF00249
Domain	EGF_CA	HMCN2 VCAN JAG1	5.57e-03	122	55	3	SM00179
Domain	MYB_LIKE	TADA2A MYB	5.59e-03	38	55	2	PS50090
Domain	EGF-like_Ca-bd_dom	HMCN2 VCAN JAG1	5.83e-03	124	55	3	IPR001881
Pubmed	Expression of P16 in NUT carcinomas with no association with human papillomavirus (HPV).	CDKN2A NUTM1	2.83e-06	2	59	2	24185123
Pubmed	Hepatitis B virus X protein promotes hypermethylation of p16(INK4A) promoter through upregulation of DNA methyltransferases in hepatocarcinogenesis.	CDKN2A DNMT1	8.48e-06	3	59	2	20620135
Pubmed	Hepatitis C virus Core protein stimulates cell growth by down-regulating p16 expression via DNA methylation.	CDKN2A DNMT1	8.48e-06	3	59	2	21757290
Pubmed	Luteolin induces apoptosis in BE colorectal cancer cells by downregulating calpain, UHRF1, and DNMT1 expressions.	CDKN2A DNMT1	8.48e-06	3	59	2	25207720
Pubmed	Hepatitis B virus X protein induces p16 gene promoter methylation through upregulation of DNA methylation transferases DNMT1 and DNMT3A.	CDKN2A DNMT1	8.48e-06	3	59	2	36482819
Pubmed	DNA (cytosine-5)-methyltransferase 1 as a mediator of mutant p53-determined p16(ink4A) down-regulation.	CDKN2A DNMT1	8.48e-06	3	59	2	18038118
Pubmed	Over-expression of DNA methyltransferases and CDKN2A gene methylation status in squamous cell carcinoma of the oral cavity.	CDKN2A DNMT1	1.69e-05	4	59	2	12738984
Pubmed	Transcriptional regulators Myb and BCL11A interplay with DNA methyltransferase 1 in developmental silencing of embryonic and fetal β-like globin genes.	MYB DNMT1	1.69e-05	4	59	2	24371119
Pubmed	HIV-1 Tat induces DNMT over-expression through microRNA dysregulation in HIV-related non Hodgkin lymphomas.	CDKN2A DNMT1	2.82e-05	5	59	2	25705251
Pubmed	Birth-and-death long-term evolution promotes histone H2B variant diversification in the male germinal cell line.	H2BC20P H2BC19P	4.23e-05	6	59	2	20194426
Pubmed	ATM mediates pRB function to control DNMT1 protein stability and DNA methylation.	CDKN2A DNMT1	4.23e-05	6	59	2	23754744
Pubmed	Endothelial deletion of murine Jag1 leads to valve calcification and congenital heart defects associated with Alagille syndrome.	VCAN JAG1	1.01e-04	9	59	2	23095891
Pubmed	Regulation of GATA-3 expression during CD4 lineage differentiation.	LCK MYB	1.26e-04	10	59	2	21357543
Pubmed	GDE2 promotes neurogenesis by glycosylphosphatidylinositol-anchor cleavage of RECK.	JAG1 VSX2	1.26e-04	10	59	2	23329048
Pubmed	PIBF1 regulates trophoblast syncytialization and promotes cardiovascular development.	VCAN JAG1 PCDH12	1.41e-04	59	59	3	38374152
Pubmed	Functional characterization of a human histone gene cluster duplication.	H2BC20P H2BC19P	1.54e-04	11	59	2	15527963
Pubmed	The human plasma proteome: a nonredundant list developed by combination of four separate sources.	CLEC3B F2 CTSA TG	1.81e-04	165	59	4	14718574
Pubmed	Progressive alopecia reveals decreasing stem cell activation probability during aging of mice with epidermal deletion of DNA methyltransferase 1.	CDKN2A DNMT1	1.85e-04	12	59	2	22763785
Pubmed	Loss of p27Kip1 function results in increased proliferative capacity of oligodendrocyte progenitors but unaltered timing of differentiation.	CDKN2A VCAN	1.85e-04	12	59	2	10457012
Pubmed	FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.	CACNA1C NWD1 SLC4A1AP POLRMT F2 AKAP8L	1.96e-04	497	59	6	36774506
Pubmed	Two Notch ligands, Dll1 and Jag1, are differently restricted in their range of action to control neurogenesis in the mammalian spinal cord.	JAG1 VSX2	2.18e-04	13	59	2	21124801
Pubmed	JAGGED1/NOTCH3 activation promotes aortic hypermuscularization and stenosis in elastin deficiency.	JAG1 DNMT1	2.18e-04	13	59	2	34990407
Pubmed	Molecular determinants of epithelial mesenchymal transition in mouse placenta and trophoblast stem cell.	VCAN JAG1	2.54e-04	14	59	2	37414855
Pubmed	Usefulness of genetic polymorphisms and conventional risk factors to predict coronary heart disease in patients with familial hypercholesterolemia.	CDKN2A F2	2.93e-04	15	59	2	19166692
Pubmed	Novel RFLPs at protooncogene and cancer-related gene loci on mouse chromosomes.	LCK MYB	3.34e-04	16	59	2	8095010
Pubmed	Expression of LIM-homeodomain transcription factors in the developing and mature mouse retina.	VSX2 TRIM47	3.34e-04	16	59	2	24333658
Pubmed	New gene functions in megakaryopoiesis and platelet formation.	CDKN2A ITPK1 MYB	3.60e-04	81	59	3	22139419
Pubmed	Asymmetric activation of Dll4-Notch signaling by Foxn4 and proneural factors activates BMP/TGFβ signaling to specify V2b interneurons in the spinal cord.	JAG1 VSX2	3.79e-04	17	59	2	24257627
Pubmed	Substrate and functional diversity of lysine acetylation revealed by a proteomics survey.	H2BC20P H2BC19P VSX2 DNMT1	3.99e-04	203	59	4	16916647
Pubmed	Ezh2 maintains retinal progenitor proliferation, transcriptional integrity, and the timing of late differentiation.	CDKN2A VSX2	4.25e-04	18	59	2	25989023
Pubmed	Inhibition of core histones acetylation by carcinogenic nickel(II).	H2BC20P H2BC19P	4.25e-04	18	59	2	16283522
Pubmed	eNOS plays essential roles in the developing heart and aorta linked to disruption of Notch signalling.	VCAN JAG1	4.25e-04	18	59	2	38111957
Pubmed	Apoptotic phosphorylation of histone H2B is mediated by mammalian sterile twenty kinase.	H2BC20P H2BC19P	4.25e-04	18	59	2	12757711
Pubmed	A mega-analysis of genome-wide association studies for major depressive disorder.	VWA5B2 HTR3E	4.75e-04	19	59	2	22472876
Pubmed	The polycomb proteins EZH1 and EZH2 co-regulate chromatin accessibility and nephron progenitor cell lifespan in mice.	CDKN2A JAG1	4.75e-04	19	59	2	32554463
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	CDKN2A HMCN2 ABCA12 POLRMT HIC2 TADA2A PHIP AKAP8L	5.70e-04	1116	59	8	31753913
Pubmed	Transduction of graded Hedgehog signaling by a combination of Gli2 and Gli3 activator functions in the developing spinal cord.	JAG1 VSX2	6.39e-04	22	59	2	15215207
Pubmed	DNA Methyltransferase 1 Controls Nephron Progenitor Cell Renewal and Differentiation.	JAG1 DNMT1	6.39e-04	22	59	2	30518531
Pubmed	Chromosomal localization of glutamate receptor genes: relationship to familial amyotrophic lateral sclerosis and other neurological disorders of mice and humans.	LCK MYB	7.00e-04	23	59	2	8464923
Pubmed	Loss of function of the maternal membrane oestrogen receptor ERα alters expansion of trophoblast cells and impacts mouse fertility.	JAG1 PCDH12	7.00e-04	23	59	2	36239412
Pubmed	Myocardial Angiopoietin-1 Controls Atrial Chamber Morphogenesis by Spatiotemporal Degradation of Cardiac Jelly.	VCAN JAG1	7.62e-04	24	59	2	29791855
Pubmed	DNA Methylation-Dependent Restriction of Tyrosine Hydroxylase Contributes to Pancreatic β-Cell Heterogeneity.	CDKN2A DNMT1	8.28e-04	25	59	2	36607262
Pubmed	The E3 ligase Mind bomb-1 (Mib1) modulates Delta-Notch signaling to control neurogenesis and gliogenesis in the developing spinal cord.	JAG1 VSX2	8.28e-04	25	59	2	23223237
Pubmed	Dll1 and Dll4 function sequentially in the retina and pV2 domain of the spinal cord to regulate neurogenesis and create cell diversity.	JAG1 VSX2	8.28e-04	25	59	2	19389377
Pubmed	The structural role of radial glial endfeet in confining spinal motor neuron somata is controlled by the Reelin and Notch pathways.	JAG1 VSX2	8.96e-04	26	59	2	23988635
Pubmed	Adamts18 modulates the development of the aortic arch and common carotid artery.	VCAN JAG1	8.96e-04	26	59	2	34189436
Pubmed	Domain-specific control of neurogenesis achieved through patterned regulation of Notch ligand expression.	JAG1 VSX2	9.66e-04	27	59	2	20081190
Pubmed	A novel source of arterial valve cells linked to bicuspid aortic valve without raphe in mice.	VCAN JAG1	9.66e-04	27	59	2	29956664
Pubmed	Functional and Evolutionary Diversification of Otx2 and Crx in Vertebrate Retinal Photoreceptor and Bipolar Cell Development.	VSX2 TRIM47	9.66e-04	27	59	2	31968244
Pubmed	Gene expression is dynamically regulated in retinal progenitor cells prior to and during overt cellular differentiation.	JAG1 VSX2	9.66e-04	27	59	2	24148613
Pubmed	Roles of histone H3K27 trimethylase Ezh2 in retinal proliferation and differentiation.	CDKN2A VSX2	1.12e-03	29	59	2	25556712
Pubmed	Chromatin Remodeling Enzyme Snf2h Is Essential for Retinal Cell Proliferation and Photoreceptor Maintenance.	CDKN2A VSX2	1.19e-03	30	59	2	37048108
Pubmed	Etv4 and Etv5 are required downstream of GDNF and Ret for kidney branching morphogenesis.	JAG1 MYB	1.27e-03	31	59	2	19898483
Pubmed	STK11 is required for the normal program of ciliated cell differentiation in airways.	JAG1 MYB	1.27e-03	31	59	2	31636950
Pubmed	Conditional ablation of the Notch2 receptor in the ocular lens.	CDKN2A JAG1	1.27e-03	31	59	2	22173065
Pubmed	Normal Molecular Specification and Neurodegenerative Disease-Like Death of Spinal Neurons Lacking the SNARE-Associated Synaptic Protein Munc18-1.	CACNA1C VSX2	1.36e-03	32	59	2	26758845
Pubmed	The Retinal Pigment Epithelium Is a Notch Signaling Niche in the Mouse Retina.	JAG1 VSX2	1.62e-03	35	59	2	28402857
Drug	S110 compound	CDKN2A DNMT1	6.38e-06	2	58	2	ctd:C551539
Drug	AC1L18R8	CDKN2A HK3 VCAN TADA2A DNMT1	7.15e-06	105	58	5	CID000050261
Disease	Carcinoma, Pancreatic Ductal	CDKN2A JAG1 DNMT1	1.27e-05	24	56	3	C0887833
Disease	lymphocyte count	USP50 TNIK TBC1D16 CDKN2A NWD1 UCHL5 JAG1 TADA2A F2 ITPK1 MYB DNMT1	1.56e-05	1464	56	12	EFO_0004587
Disease	Hereditary Sensory Autonomic Neuropathy, Type 5	SCN11A DNMT1	7.38e-05	7	56	2	C0020075
Disease	Anxiety States, Neurotic	CACNA1C DNMT1 TG	8.11e-05	44	56	3	C0376280
Disease	Anxiety Disorders	CACNA1C DNMT1 TG	8.11e-05	44	56	3	C0003469
Disease	Anxiety neurosis (finding)	CACNA1C DNMT1 TG	8.11e-05	44	56	3	C1279420
Disease	Bone Diseases	CDKN2A JAG1	1.58e-04	10	56	2	C0005940
Disease	spine bone size	VSX2 LIN52	5.31e-04	18	56	2	EFO_0004508
Disease	ectonucleoside triphosphate diphosphohydrolase 5 measurement	VSX2 LIN52	7.26e-04	21	56	2	EFO_0008115
Disease	monocyte count	CDKN2A VCAN JAG1 TADA2A F2 COQ2 ITPK1 MYB DNMT1	7.93e-04	1320	56	9	EFO_0005091
Disease	corpus callosum volume measurement	TNIK JAG1 TG	9.19e-04	100	56	3	EFO_0010299
Disease	Adenoid Cystic Carcinoma	VCAN JAG1 MYB	9.19e-04	100	56	3	C0010606
Disease	Involutional paraphrenia	CACNA1C XDH	1.03e-03	25	56	2	C1571983
Disease	Psychosis, Involutional	CACNA1C XDH	1.03e-03	25	56	2	C1571984
Disease	Involutional Depression	CACNA1C XDH	1.03e-03	25	56	2	C0011574
Disease	urinary bladder cancer (is_marker_for)	CDKN2A F2 DNMT1	1.12e-03	107	56	3	DOID:11054 (is_marker_for)
Disease	hepatocellular carcinoma (biomarker_via_orthology)	CDKN2A XDH DNMT1	1.15e-03	108	56	3	DOID:684 (biomarker_via_orthology)
Disease	corpus callosum mid-anterior volume measurement	JAG1 TG	1.20e-03	27	56	2	EFO_0010297
Disease	chronic myeloid leukemia (is_marker_for)	CDKN2A DNMT1	1.20e-03	27	56	2	DOID:8552 (is_marker_for)

Protein segments in the cluster

Peptide	Gene	Start	Entry
NRNMDGAMWLSLCPD	CEP295NL	56	Q96MC4
FAMGCWPKNGLLDMN	ERI3	281	O43414
MPDNNGSSMDDWEER	VCAN	611	P13611
EVWCLAGKMSIPMDG	CCIN	401	Q13939
ENWAMEGGMDPESLL	DNMT1	841	P26358
SWNPEECEGITKMSM	HTR3E	101	A5X5Y0
AMWDFPGIDNMCLNT	ABCA12	1806	Q86UK0
MLMSWSPEECKGQGE	ASB10	1	Q8WXI3
WEDPMGARGQCMSGA	AKAP8L	201	Q9ULX6
LGDASDPWMCMAVLA	NWD1	996	Q149M9
CPWMEGGEMSPQVET	INTS4	926	Q96HW7
EAMMEAGWDPCLQAP	PCDH12	801	Q9NPG4
LMRGAGCTINDMWDQ	COQ2	121	Q96H96
CCGSMMGQDAPWKAE	ITPK1	361	Q13572
MGWKMASPTDGTDLE	LIN52	1	Q52LA3
PDTGIWCKAMGIMNS	H2BC20P	51	Q6DN03
PDTGIWCKAMGIMNS	H2BC19P	51	Q6DRA6
GSMWDELMQVIDGAS	HMCN2	46	Q8NDA2
DGGAGWRMDCDPQMH	FAM184B	21	Q9ULE4
WMDIGQPKDFLTGMC	GMPPB	216	Q9Y5P6
DMSLMEGDNGWIPET	HPS5	1011	Q9UPZ3
DGGEGCSWMFQPMNN	BEND2	611	Q8NDZ0
MGCGCSSHPEDDWME	LCK	1	P06239
STWEPASCGKMEEQM	MYB	606	P10242
GVPGDSGRMCINMEW	HK3	701	P52790
GAMWGDDRGTPMAQS	NUTM1	686	Q86Y26
SMIWDSMFCAGAEDG	PRSS41	226	Q7RTY9
NGDVDMACNFMGDEW	CTSA	396	P10619
MEPAAGSSMEPSADW	CDKN2A	1	P42771
ATGEAWQDIMLACMP	CACNA1C	1461	Q13936
MLCDQAWGSMLEVPA	CCDC3	81	Q9BQI4
EWNPFDQDAVGMLCM	DENND5A	86	Q6IQ26
MGAEEPWQTLACCME	POLRMT	886	O00411
MEGWMGPECNRAICR	JAG1	221	P78504
CAWAGRGDMGPDMEL	HIC2	11	Q96JB3
GWVSMGVMAEDFSPQ	TRIM47	491	Q96LD4
MALLEAVMDCGFGNW	TADA2A	81	O75478
LEGSMGSEMAGNEAW	SPATA31E1	986	Q6ZUB1
AMDWGPSLEENRTGM	SLC6A7	576	Q99884
MMLHTGLWNDAPCDS	CLEC4G	266	Q6UXB4
MTGNAGEWCLMESDP	UCHL5	1	Q9Y5K5
GMDDQLWLVMEFCGA	TNIK	96	Q9UKE5
MGWSDLQPAMGGEAE	nan	1	Q6ZTK2
CWDNGDTEKMSPWDM	PHIP	1106	Q8WWQ0
DMGSLASAWEVEAMP	STEAP3	191	Q658P3
NDMAAEGTWVDMTGA	CLEC3B	136	P05452
GSGMWDSGSMPAVEC	TBC1D16	711	Q8TBP0
WMMEREVTGDPCPAC	ZNF840P	101	A6NDX5
MTDMWLGDSDCVSPE	USP50	101	Q70EL3
GGPQGMLIAECWMSE	XDH	916	P47989
CWMSEVAVTCGMPAE	XDH	926	P47989
DSGNLLSPAPMDWDM	VWA5B2	796	Q8N398
DTPGGFCLDWMTMPA	ZNF454	76	Q8N9F8
EGSDAEIGMSPWQVM	F2	366	P00734
NSPEFKMCGIWMGNS	SCN11A	306	Q9UI33
SLMCPNECVMSEWGL	THSD7B	1121	Q9C0I4
MGDQFIMLSCEWPGG	VSIG10L2	426	P0DP72
WKDSDMGSRPESMGC	TG	1821	P01266
KDGIMDSCAPWLLGM	VSX2	241	P58304
GVEQDPGTMSMWDCT	LRRC14	126	Q15048
NAGSQDDEMGCTWGM	SLC4A1AP	326	Q9BWU0