Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionmonoatomic ion transmembrane transporter activity

CNNM2 PIEZO1 SLC10A4 SLC25A14 TMC6 STING1 ITGAV RYR3 TRPM5 SLC16A3 SLC15A1 TMC8 CACNA1H SLC39A5 SLC9A6

5.56e-0579311615GO:0015075
GeneOntologyMolecularFunctionmonoatomic cation transmembrane transporter activity

CNNM2 PIEZO1 SLC10A4 SLC25A14 STING1 ITGAV RYR3 TRPM5 SLC16A3 SLC15A1 CACNA1H SLC39A5 SLC9A6

1.28e-0466411613GO:0008324
GeneOntologyMolecularFunctionmechanosensitive monoatomic ion channel activity

PIEZO1 TMC6 TMC8

1.46e-04181163GO:0008381
GeneOntologyMolecularFunctiontransmembrane transporter activity

CNNM2 PIEZO1 SLC10A4 SLC25A14 TMC6 STING1 ITGAV RYR3 TRPM5 SLC16A4 SLC16A3 SLC15A1 TMC8 GSDMA CACNA1H SLC39A5 SLC9A6 SLC27A2

1.54e-04118011618GO:0022857
GeneOntologyMolecularFunctionneuropeptide Y receptor binding

PYY NPY

1.99e-0441162GO:0031841
GeneOntologyMolecularFunctioninorganic cation transmembrane transporter activity

CNNM2 SLC10A4 SLC25A14 STING1 ITGAV RYR3 TRPM5 SLC16A3 SLC15A1 CACNA1H SLC39A5 SLC9A6

2.90e-0462711612GO:0022890
GeneOntologyMolecularFunctiontransporter activity

CNNM2 PIEZO1 SLC10A4 SLC25A14 TMC6 STING1 ITGAV RYR3 TRPM5 SLC16A4 SLC16A3 SLC15A1 TMC8 GSDMA CACNA1H SLC39A5 SLC9A6 SLC27A2

4.50e-04128911618GO:0005215
GeneOntologyBiologicalProcessregulation of antibacterial peptide production

EVPL NOD2 KLK5

1.42e-0591163GO:0002786
GeneOntologyBiologicalProcessregulation of antimicrobial peptide production

EVPL NOD2 KLK5

2.77e-05111163GO:0002784
GeneOntologyBiologicalProcessantibacterial peptide production

EVPL NOD2 KLK5

3.67e-05121163GO:0002778
GeneOntologyBiologicalProcessregulation of antimicrobial humoral response

EVPL NOD2 KLK5

6.03e-05141163GO:0002759
GeneOntologyBiologicalProcessantimicrobial peptide production

EVPL NOD2 KLK5

6.03e-05141163GO:0002775
GeneOntologyCellularComponentendoplasmic reticulum membrane

NAT8L TAPT1 AUP1 DIPK1A PIEZO1 TMC6 WDR81 DIPK1B XK TMEM214 STING1 CYP2S1 RYR3 PIGQ NBAS TMC8 DISP3 UGT2B28 ALG6 MYMX SLC9A6 SLC27A2

2.20e-06129311622GO:0005789
GeneOntologyCellularComponentendoplasmic reticulum subcompartment

NAT8L TAPT1 AUP1 DIPK1A PIEZO1 TMC6 WDR81 DIPK1B XK TMEM214 STING1 CYP2S1 RYR3 PIGQ NBAS TMC8 DISP3 UGT2B28 ALG6 MYMX SLC9A6 SLC27A2

2.37e-06129911622GO:0098827
GeneOntologyCellularComponentnuclear outer membrane-endoplasmic reticulum membrane network

NAT8L TAPT1 AUP1 DIPK1A PIEZO1 TMC6 WDR81 DIPK1B XK TMEM214 STING1 CYP2S1 RYR3 PIGQ NBAS TMC8 DISP3 UGT2B28 ALG6 MYMX SLC9A6 SLC27A2

3.36e-06132711622GO:0042175
GeneOntologyCellularComponentintegrin alphav-beta5 complex

ITGAV ITGB5

3.05e-0521162GO:0034684
GeneOntologyCellularComponentlamellipodium membrane

DOCK8 PIEZO1 ITGAV

2.37e-04221163GO:0031258
DomainPancreatic_hormone-like

PYY NPY

1.08e-0431132PD001267
DomainPAH

PYY NPY

1.08e-0431132SM00309
DomainPancreatic_hormone-like_CS

PYY NPY

1.08e-0431132IPR020392
DomainNNMT/PNMT/TEMT_CS

INMT NNMT

1.08e-0431132IPR025820
DomainPIP49_N

DIPK1A DIPK1B

1.08e-0431132PF14875
DomainPancreatic_hormone-like

PYY NPY

1.08e-0431132IPR001955
DomainFAM69_N

DIPK1A DIPK1B

1.08e-0431132IPR029244
DomainNNMT_TEMT_trans

INMT NNMT

1.08e-0431132IPR000940
DomainPANCREATIC_HORMONE_2

PYY NPY

1.08e-0431132PS50276
DomainHormone_3

PYY NPY

1.08e-0431132PF00159
DomainPIP49_N

DIPK1A DIPK1B

1.08e-0431132SM01299
DomainSAM_MT_NNMT_PNMT_TEMT

INMT NNMT

1.08e-0431132PS51681
DomainNNMT_PNMT_TEMT

INMT NNMT

1.08e-0431132PF01234
DomainPANCREATIC_HORMONE_1

PYY NPY

1.08e-0431132PS00265
DomainNNMT_PNMT_TEMT

INMT NNMT

1.08e-0431132PS01100
DomainFAT

TRRAP PRKDC

5.36e-0461132PS51189
DomainFATC

TRRAP PRKDC

5.36e-0461132PS51190
DomainFAD-bd

MICAL1 RNLS

5.36e-0461132IPR002938
DomainFAT

TRRAP PRKDC

5.36e-0461132PF02259
DomainPIK-rel_kinase_FAT

TRRAP PRKDC

5.36e-0461132IPR003151
DomainFATC_dom

TRRAP PRKDC

5.36e-0461132IPR003152
DomainPIP49_C

DIPK1A DIPK1B

5.36e-0461132PF12260
DomainFAD_binding_3

MICAL1 RNLS

5.36e-0461132PF01494
DomainPIK_FAT

TRRAP PRKDC

5.36e-0461132IPR014009
DomainFATC

TRRAP PRKDC

5.36e-0461132SM01343
DomainFAM69_kinase_dom

DIPK1A DIPK1B

5.36e-0461132IPR022049
DomainTMC

TMC6 TMC8

9.92e-0481132PF07810
DomainTMC

TMC6 TMC8

9.92e-0481132IPR012496
Domain-

TRRAP PRKDC

4.12e-031611321.10.1070.11
DomainPI3Kc

TRRAP PRKDC

4.12e-03161132SM00146
DomainLRR_6

FBXL6 NOD2 LRRC14

4.50e-03551133PF13516
DomainARM-type_fold

MYBBP1A DOCK8 HEATR5A TRRAP TRIP12 RYR3 PRKDC

4.56e-033391137IPR016024
DomainPI3/4_kinase_cat_dom

TRRAP PRKDC

5.21e-03181132IPR000403
DomainPI3_PI4_kinase

TRRAP PRKDC

5.21e-03181132PF00454
DomainPI3_4_KINASE_3

TRRAP PRKDC

5.21e-03181132PS50290
DomainPI3_4_KINASE_1

TRRAP PRKDC

5.21e-03181132PS00915
DomainPI3_4_KINASE_2

TRRAP PRKDC

5.21e-03181132PS00916
Pubmed

The differentiation of pancreatic tumor-initiating cells by vitronectin can be blocked by cilengitide.

ITGAV ITGB5

1.12e-052117223462327
Pubmed

Integrin-nucleated Toll-like receptor (TLR) dimerization reveals subcellular targeting of TLRs and distinct mechanisms of TLR4 activation and signaling.

ITGAV ITGB5

1.12e-052117212459484
Pubmed

 Fibrin-mediated integrin signaling plays a critical role in hepatic regeneration after partial hepatectomy in mice.

ITGAV ITGB5

1.12e-052117227493116
Pubmed

AlphaVBeta5 integrins mediates Pseudomonas fluorescens interaction with A549 cells.

ITGAV ITGB5

1.12e-052117224389192
Pubmed

Y receptor-mediated induction of CD63 transcripts, a tetraspanin determined to be necessary for differentiation of the intestinal epithelial cell line, hBRIE 380i cells.

PYY NPY

1.12e-052117210488139
Pubmed

Knockdown of Astrocytic Monocarboxylate Transporter 4 in the Motor Cortex Leads to Loss of Dendritic Spines and a Deficit in Motor Learning.

SLC16A4 SLC16A3

1.12e-052117234822124
Pubmed

Characterisation of human monocarboxylate transporter 4 substantiates its role in lactic acid efflux from skeletal muscle.

SLC16A4 SLC16A3

1.12e-052117211101640
Pubmed

Saccharomyces boulardii improves intestinal epithelial cell restitution by inhibiting αvβ5 integrin activation state.

ITGAV ITGB5

1.12e-052117223028753
Pubmed

Analysis of the role of irisin receptor signaling in regulating osteogenic/adipogenic differentiation of bone marrow mesenchymal stem cells.

ITGAV ITGB5

1.12e-052117237010292
Pubmed

Risk of Cutaneous Squamous Cell Carcinoma Development in Renal Transplant Recipients Is Independent of TMC/EVER Alterations.

TMC6 TMC8

1.12e-052117226227733
Pubmed

Crystal structures of human neuropeptide Y (NPY) and peptide YY (PYY).

PYY NPY

1.12e-052117235180645
Pubmed

Autosomal dominant epidermodysplasia verruciformis lacking a known EVER1 or EVER2 mutation.

TMC6 TMC8

1.12e-052117219706093
Pubmed

Mutations in two adjacent novel genes are associated with epidermodysplasia verruciformis.

TMC6 TMC8

1.12e-052117212426567
Pubmed

EVER proteins, key elements of the natural anti-human papillomavirus barrier, are regulated upon T-cell activation.

TMC6 TMC8

1.12e-052117222761942
Pubmed

Neural retina and MerTK-independent apical polarity of alphavbeta5 integrin receptors in the retinal pigment epithelium.

ITGAV ITGB5

1.12e-052117220238010
Pubmed

Adenylyl cyclase 6 overexpression decreases the permeability of endothelial monolayers via preferential enhancement of prostacyclin receptor function.

PTGIR ADCY6

1.12e-052117216885208
Pubmed

β5 integrin is the major contributor to the αVintegrin-mediated blockade of HIV-1 replication.

ITGAV ITGB5

1.12e-052117221098231
Pubmed

Contribution of TMC6 and TMC8 (EVER1 and EVER2) variants to cervical cancer susceptibility.

TMC6 TMC8

1.12e-052117221387292
Pubmed

Genetic variations in the epidermodysplasia verruciformis (EVER/TMC) genes, cutaneous human papillomavirus infection and squamous cell carcinoma of the skin.

TMC6 TMC8

1.12e-052117226126409
Pubmed

The PepT1-NOD2 signaling pathway aggravates induced colitis in mice.

NOD2 SLC15A1

1.12e-052117221762661
Pubmed

Expression of the epidermodysplasia verruciformis-associated genes EVER1 and EVER2 is activated by exogenous DNA and inhibited by LMP1 oncoprotein from Epstein-Barr virus.

TMC6 TMC8

1.12e-052117225378492
Pubmed

Evidence for a nonallelic heterogeneity of epidermodysplasia verruciformis with two susceptibility loci mapped to chromosome regions 2p21-p24 and 17q25.

TMC6 TMC8

1.12e-052117210844558
Pubmed

Integrin alphavbeta5 is a primary receptor for adenovirus in CAR-negative cells.

ITGAV ITGB5

1.12e-052117220615244
Pubmed

The endoproteolytic processing of alphavbeta5 integrin is involved in cytoskeleton remodelling and cell migration.

ITGAV ITGB5

1.12e-052117214741360
Pubmed

A study of the structure, function and distribution of beta 5 integrins using novel anti-beta 5 monoclonal antibodies.

ITGAV ITGB5

1.12e-05211727689573
Pubmed

Definitive endoderm derived from human embryonic stem cells highly express the integrin receptors alphaV and beta5.

ITGAV ITGB5

1.12e-052117220026907
Pubmed

Elevated expression of integrin αv and β5 subunit in laryngeal squamous-cell carcinoma associated with lymphatic metastasis and angiogenesis.

ITGAV ITGB5

1.12e-052117223261238
Pubmed

Tumor-penetrating therapy for β5 integrin-rich pancreas cancer.

ITGAV ITGB5

1.12e-052117233750829
Pubmed

Inhibition of migration and invasion of carcinoma cells by urokinase-derived antagonists of alphavbeta5 integrin activation.

ITGAV ITGB5

1.12e-052117218844213
Pubmed

Cyclic DGR-peptidomimetic containing a bicyclic reverse turn inducer as a selective alpha(v)beta (5) integrin ligand.

ITGAV ITGB5

1.12e-052117219267182
Pubmed

Variants of EVER1 and EVER2 (TMC6 and TMC8) and human papillomavirus status in patients with mucosal squamous cell carcinoma of the head and neck.

TMC6 TMC8

1.12e-052117227097911
Pubmed

Novel role for alphavbeta5-integrin in retinal adhesion and its diurnal peak.

ITGAV ITGB5

1.12e-052117216338970
Pubmed

Merkel cell polyomavirus detection in a patient with familial epidermodysplasia verruciformis.

TMC6 TMC8

1.12e-052117223535066
Pubmed

Cigarette Smoke Induces Metabolic Reprogramming of the Tumor Stroma in Head and Neck Squamous Cell Carcinoma.

SLC16A4 SLC16A3

1.12e-052117231239287
Pubmed

The monocarboxylate transporter 4 is required for glycolytic reprogramming and inflammatory response in macrophages.

SLC16A4 SLC16A3

1.12e-052117225406319
Pubmed

FAM105A/OTULINL Is a Pseudodeubiquitinase of the OTU-Class that Localizes to the ER Membrane.

TAPT1 AUP1 TMEM214 STING1 ITGAV NBAS SUN2 NUP160 SLC27A2

3.07e-05468117931056421
Pubmed

ADAM-9 (MDC-9/meltrin-gamma), a member of the a disintegrin and metalloproteinase family, regulates myeloma-cell-induced interleukin-6 production in osteoblasts by direct interaction with the alpha(v)beta5 integrin.

ITGAV ITGB5

3.36e-053117216373656
Pubmed

Urokinase receptor interacts with alpha(v)beta5 vitronectin receptor, promoting urokinase-dependent cell migration in breast cancer.

ITGAV ITGB5

3.36e-053117210537314
Pubmed

Human indolethylamine N-methyltransferase: cDNA cloning and expression, gene cloning, and chromosomal localization.

INMT NNMT

3.36e-053117210552930
Pubmed

POLQ inhibition elicits an immune response in homologous recombination-deficient pancreatic adenocarcinoma via cGAS/STING signaling.

STING1 PRKDC

3.36e-053117236976649
Pubmed

MCT1 Modulates Cancer Cell Pyruvate Export and Growth of Tumors that Co-express MCT1 and MCT4.

SLC16A4 SLC16A3

3.36e-053117226876179
Pubmed

Epidermodysplasia verruciformis in lipoid proteinosis: case report and discussion of pathophysiology.

TMC6 TMC8

3.36e-053117223534907
Pubmed

Roles of integrins in human induced pluripotent stem cell growth on Matrigel and vitronectin.

ITGAV ITGB5

3.36e-053117219811096
Pubmed

The alphavbeta5 integrin functions as an endocytic receptor for vitronectin.

ITGAV ITGB5

3.36e-05311729443892
Pubmed

Involvement of alphavbeta5 integrin in the establishment of autocrine TGF-beta signaling in dermal fibroblasts derived from localized scleroderma.

ITGAV ITGB5

3.36e-053117216675963
Pubmed

Identification of motifs in the fasciclin domains of the transforming growth factor-beta-induced matrix protein betaig-h3 that interact with the alphavbeta5 integrin.

ITGAV ITGB5

3.36e-053117212270930
Pubmed

Integrin-mediated cell attachment induces a PAK4-dependent feedback loop regulating cell adhesion through modified integrin alpha v beta 5 clustering and turnover.

ITGAV ITGB5

3.36e-053117220719960
Pubmed

Integrin and defensin modulate the mechanical properties of adenovirus.

ITGAV ITGB5

3.36e-053117223269786
Pubmed

Integrin-dependent functions of the angiogenic inducer NOV (CCN3): implication in wound healing.

ITGAV ITGB5

3.36e-053117215611078
Pubmed

MDC-9 (ADAM-9/Meltrin gamma) functions as an adhesion molecule by binding the alpha(v)beta(5) integrin.

ITGAV ITGB5

3.36e-053117211162558
Pubmed

Neuropeptide Y and peptide YY have distinct roles in adult mouse olfactory neurogenesis.

PYY NPY

3.36e-053117222354615
Pubmed

MerTK activation during RPE phagocytosis in vivo requires alphaVbeta5 integrin.

ITGAV ITGB5

3.36e-053117217249615
Pubmed

Neuropeptide Y and peptide YY protect from weight loss caused by Bacille Calmette-Guérin in mice.

PYY NPY

3.36e-053117223992467
Pubmed

betaig-h3 triggers signaling pathways mediating adhesion and migration of vascular smooth muscle cells through alphavbeta5 integrin.

ITGAV ITGB5

3.36e-053117216672769
Pubmed

Immunohistochemical distribution of neuropeptide Y, peptide YY, pancreatic polypeptide-like immunoreactivity and their receptors in the epidermal skin of healthy women.

PYY NPY

3.36e-053117226002416
Pubmed

Evidence from knockout mice that peptide YY and neuropeptide Y enforce murine locomotion, exploration and ingestive behaviour in a circadian cycle- and gender-dependent manner.

PYY NPY

3.36e-053117219397935
Pubmed

Bile acids activate fibroblast growth factor 19 signaling in human hepatocytes to inhibit cholesterol 7alpha-hydroxylase gene expression.

FGFR4 NR0B2

3.36e-053117219085950
Pubmed

Microglial expression of alphavbeta3 and alphavbeta5 integrins is regulated by cytokines and the extracellular matrix: beta5 integrin null microglia show no defects in adhesion or MMP-9 expression on vitronectin.

ITGAV ITGB5

3.36e-053117218985734
Pubmed

Role of mouse peptidoglycan recognition protein PGLYRP2 in the innate immune response to Salmonella enterica serovar Typhimurium infection in vivo.

PGLYRP2 NOD2

3.36e-053117222615249
Pubmed

αvβ5 integrin-dependent diurnal phagocytosis of shed photoreceptor outer segments by RPE cells is independent of the integrin coreceptor transglutaminase-2.

ITGAV ITGB5

3.36e-053117222183400
Pubmed

Interleukin-1beta causes acute lung injury via alphavbeta5 and alphavbeta6 integrin-dependent mechanisms.

ITGAV ITGB5

3.36e-053117218276918
Pubmed

Significance of integrin αvβ5 and erbB3 in enhanced cell migration and liver metastasis of colon carcinomas stimulated by hepatocyte-derived heregulin.

ITGAV ITGB5

3.36e-053117220626753
Pubmed

Microglia use multiple mechanisms to mediate interactions with vitronectin; non-essential roles for the highly-expressed αvβ3 and αvβ5 integrins.

ITGAV ITGB5

3.36e-053117222074485
Pubmed

Characterisation of the FAM69 family of cysteine-rich endoplasmic reticulum proteins.

DIPK1A DIPK1B

3.36e-053117221334309
Pubmed

The human CIB1-EVER1-EVER2 complex governs keratinocyte-intrinsic immunity to β-papillomaviruses.

TMC6 TMC8

3.36e-053117230068544
Pubmed

Zika Virus Targets Glioblastoma Stem Cells through a SOX2-Integrin αvβ5 Axis.

ITGAV ITGB5

3.36e-053117231956038
Pubmed

Targeting ανβ3 and ανβ5 inhibits photon-induced hypermigration of malignant glioma cells.

ITGAV ITGB5

3.36e-053117221978494
Pubmed

Neuropeptide Y, peptide YY and pancreatic polypeptide in the gut-brain axis.

PYY NPY

3.36e-053117222979996
Pubmed

NPY modulates PYY function in the regulation of energy balance and glucose homeostasis.

PYY NPY

3.36e-053117222369253
Pubmed

Structural basis for Y2 receptor-mediated neuropeptide Y and peptide YY signaling.

PYY NPY

3.36e-053117236525977
Pubmed

Cross talk between engulfment receptors stabilin-2 and integrin αvβ5 orchestrates engulfment of phosphatidylserine-exposed erythrocytes.

ITGAV ITGB5

3.36e-053117222566688
Pubmed

Langerhans cell expression of neuropeptide Y and peptide YY.

PYY NPY

3.36e-053117212372697
Pubmed

Expression of a TMC6-TMC8-CIB1 heterotrimeric complex in lymphocytes is regulated by each of the components.

TMC6 TMC8

3.36e-053117232917726
Pubmed

Mechanism of tissue-specific farnesoid X receptor in suppressing the expression of genes in bile-acid synthesis in mice.

FGFR4 NR0B2

3.36e-053117222467244
Pubmed

Treadmill Exercise Alleviates Cognition Disorder by Activating the FNDC5: Dual Role of Integrin αV/β5 in Parkinson's Disease.

ITGAV ITGB5

3.36e-053117237175535
Pubmed

Sex-dependent control of murine emotional-affective behaviour in health and colitis by peptide YY and neuropeptide Y.

PYY NPY

3.36e-053117221410462
Pubmed

CYR61 stimulates human skin fibroblast migration through Integrin alpha vbeta 5 and enhances mitogenesis through integrin alpha vbeta 3, independent of its carboxyl-terminal domain.

ITGAV ITGB5

3.36e-053117211287419
Pubmed

Autoregulation of insulin receptor signaling through MFGE8 and the αvβ5 integrin.

ITGAV ITGB5

3.36e-053117233903257
Pubmed

Peptide YY is critical for acylethanolamine receptor Gpr119-induced activation of gastrointestinal mucosal responses.

PYY NPY

3.36e-053117220519124
Pubmed

Alternate expression of PEPT1 and PEPT2 in epidermal differentiation is required for NOD2 immune responses by bacteria-derived muramyl dipeptide.

NOD2 SLC15A1

3.36e-053117231757425
Pubmed

Genetic polymorphisms of FAS and EVER genes in a Greek population and their susceptibility to cervical cancer: a case control study.

TMC6 TMC8

3.36e-053117227899077
Pubmed

Genetic determinants of disease progression in Alzheimer's disease.

ADAM19 PIGQ

3.36e-053117225114068
Pubmed

The apoptotic-cell receptor CR3, but not alphavbeta5, is a regulator of human dendritic-cell immunostimulatory function.

ITGAV ITGB5

3.36e-053117216614246
Pubmed

Cloning of human genes encoding novel G protein-coupled receptors.

CMKLR2 CCR10

3.36e-05311727851889
Pubmed

CCN1 induces hepatic ductular reaction through integrin αvβ₅-mediated activation of NF-κB.

ITGAV ITGB5

3.36e-053117225822023
Pubmed

Regulation of cellular zinc balance as a potential mechanism of EVER-mediated protection against pathogenesis by cutaneous oncogenic human papillomaviruses.

TMC6 TMC8

3.36e-053117218158319
Pubmed

C5orf51 is a component of the MON1-CCZ1 complex and controls RAB7A localization and stability during mitophagy.

TAPT1 DSG2 AUP1 WDR81 TMEM214 ITGAV NBAS SUN2 RHBDD3

5.43e-05504117934432599
Pubmed

Regulation of membrane fluidity by RNF145-triggered degradation of the lipid hydrolase ADIPOR2.

AUP1 CYP2S1 GSDMA SLC27A2

6.22e-0563117435993436
Pubmed

Integrin alpha v beta 8. Interaction with vitronectin and functional divergence of the beta 8 cytoplasmic domain.

ITGAV ITGB5

6.70e-05411727525578
Pubmed

Cross-talk between fMLP and vitronectin receptors triggered by urokinase receptor-derived SRSRY peptide.

ITGAV ITGB5

6.70e-054117215866865
Pubmed

Comparing the expression of integrins αvβ3, αvβ5, αvβ6, αvβ8, fibronectin and fibrinogen in human brain metastases and their corresponding primary tumors.

ITGAV ITGB5

6.70e-054117224294359
Pubmed

Myelin proteolipid protein forms a complex with integrins and may participate in integrin receptor signaling in oligodendrocytes.

ITGAV ITGB5

6.70e-054117212196561
Pubmed

Integrins αvβ5 and αvβ3 promote latent TGF-β1 activation by human cardiac fibroblast contraction.

ITGAV ITGB5

6.70e-054117224639195
Pubmed

A novel integrin specificity exemplified by binding of the alpha v beta 5 integrin to the basic domain of the HIV Tat protein and vitronectin.

ITGAV ITGB5

6.70e-05411727682219
Pubmed

The proton-linked monocarboxylate transporter (MCT) family: structure, function and regulation.

SLC16A4 SLC16A3

6.70e-054117210510291
Pubmed

Granulocyte macrophage-colony stimulating factor reciprocally regulates alphav-associated integrins on murine osteoclast precursors.

ITGAV ITGB5

6.70e-05411729849968
Pubmed

P21-activated kinase 4 interacts with integrin alpha v beta 5 and regulates alpha v beta 5-mediated cell migration.

ITGAV ITGB5

6.70e-054117212356872
Pubmed

Polarized expression of monocarboxylate transporters in human retinal pigment epithelium and ARPE-19 cells.

SLC16A4 SLC16A3

6.70e-054117212657613
Pubmed

CTGF increases IL-6 expression in human synovial fibroblasts through integrin-dependent signaling pathway.

ITGAV ITGB5

6.70e-054117223227240
Pubmed

CD147 is tightly associated with lactate transporters MCT1 and MCT4 and facilitates their cell surface expression.

SLC16A4 SLC16A3

6.70e-054117210921872
InteractionST7 interactions

TAPT1 DSG2 AUP1 EVPL TMEM214 STING1 ST7L ITGAV NBAS P2RY6 SUN2 GSDMA

8.29e-0736211212int:ST7
InteractionZNF610 interactions

TRRAP ZNF610 HERC1

5.75e-0671123int:ZNF610
InteractionC3orf52 interactions

NAT8L PIEZO1 TMC6 CYP2S1 ST7L ADCY6 NBAS TMEM245 SIGLECL1 SLC27A2

7.89e-0630511210int:C3orf52
InteractionTTI1 interactions

FFAR1 HEATR5A TRRAP SIGLECL1 PRKDC HERC1

2.12e-051011126int:TTI1
InteractionFKBP8 interactions

AUP1 TMEM214 CPZ STING1 TRRAP FBXL6 NBAS P2RY6 BNIPL LRRC61 PRKDC NUP160

4.54e-0553811212int:FKBP8
InteractionTTYH1 interactions

PIEZO1 TMC6 TMEM214 ST7L ADCY6 PIGQ S1PR5 CACNA1H SLC27A2

4.58e-053001129int:TTYH1
Cytoband14q31

GALC GPR68

2.29e-049117214q31
CytobandEnsembl 112 genes in cytogenetic band chr19q13

FFAR1 SIGLEC5 CYP2S1 PTGIR ZNF610 NTN5 ZNF766 ZNF528 SIGLECL1 KLK5 TDRD12

2.44e-04119211711chr19q13
GeneFamilySolute carriers

SLC10A4 SLC25A14 SLC16A4 SLC16A3 SLC15A1 SLC39A5 SLC9A6 SLC27A2

2.49e-04395768752
GeneFamilyTransmembrane channel likes

TMC6 TMC8

4.80e-0487621135
ToppCellfacs-Brain_Non-Myeloid-Hippocampus-3m-Lymphocytic-T_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DOCK8 PGLYRP2 STING1 CYP2S1 CD247 IFI30 NNMT NPY

1.22e-0816311788028636632c168dc50731d0ebecaf88a70daf81d
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW23-Mesenchymal|GW23 / Sample Type, Dataset, Time_group, and Cell type.

DOCK8 PIEZO1 TMC6 STING1 ITGB5 DENND3 IFI30

1.01e-0620011770eccf41edefc3b8b5d0316f57d5ba572949aec2b
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW23-Mesenchymal-BMP_responsible_cell|GW23 / Sample Type, Dataset, Time_group, and Cell type.

DOCK8 PIEZO1 TMC6 STING1 ITGB5 DENND3 IFI30

1.01e-06200117701d707c4f8ee0daac635b7260937b1baebc6fc23
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW10-Mesenchymal|GW10 / Sample Type, Dataset, Time_group, and Cell type.

PIK3AP1 PIEZO1 TMC6 STING1 DENND3 P2RY6 RD3

1.01e-0620011775c638c80661017c85f9390f1b398ac7728c8f001
ToppCellCOVID-19_Moderate-MAIT|COVID-19_Moderate / disease group, cell group and cell class

TMC6 EVPL ZNF610 CD247 ABCE1 NNMT

4.01e-0615911766d08d670c34eb6bb8ad5dad3293b3107c006236d
ToppCellControl-NK|Control / Disease group and Cell class

CDHR1 CYP2S1 DENND3 SLC16A3 P2RY6 PRSS27

5.50e-061681176683d389c8a1e791bfc773e63148115a21a6566db
ToppCelldroplet-Lung-nan-18m-Myeloid-Interstitial_Macrophage|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADAM19 ITGAV TRRAP ITGB5 P2RY6 RHBDD3

6.09e-0617111767ca404539344e14dcd90c746c9122f713a7db78b
ToppCelldroplet-Lung-nan-18m-Myeloid-lung_macrophage|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADAM19 ITGAV TRRAP ITGB5 P2RY6 RHBDD3

6.09e-061711176ab113c8e773b0af47a87aed50e96be3ba71c3c82
ToppCellControl-T/NK-NK|Control / Disease group,lineage and cell class （2021.01.30）

DAB2IP CDHR1 SLFN5 CD247 PRSS27 GPR68

7.66e-061781176079fd19bdeed86bf985c4083af432432d66ad546
ToppCellfacs-Limb_Muscle-ForelimbandHindlimb-24m-Endothelial-nan|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PYY STING1 SLFN5 DENND3 KLK5 TMEM252

8.43e-0618111760756d7d315b8cdd07a3cf6cdfc8a0679786b8e6a
ToppCellfacs-Limb_Muscle-ForelimbandHindlimb-24m-Endothelial-endothelial_cell|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PYY STING1 SLFN5 DENND3 KLK5 TMEM252

8.43e-061811176b09947d2d7b21f96d98b87ceb6f467ea329c4092
ToppCellfacs-Limb_Muscle-ForelimbandHindlimb-24m-Endothelial|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PYY STING1 SLFN5 DENND3 KLK5 TMEM252

8.43e-0618111763f0d88e9506d66d4e71b88c50d5187302065930f
ToppCellControl-Myeloid|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PIK3AP1 DOCK8 SIGLEC5 NOD2 PLXNC1 IFI30

8.43e-06181117625170e5285996cc80337d5f86a0255569861ae77
ToppCellCTRL-Myeloid-cDC|CTRL / Disease state, Lineage and Cell class

ADAM19 DIPK1A CYP2S1 PTGIR P2RY6 PLXNC1

8.97e-06183117620c4d16de7e090df3556a4458f783383a26871b6
ToppCelldroplet-Kidney-KIDNEY-1m-Lymphocytic-CD45____T_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CCR10 PGLYRP2 CD247 PRSS27 SUN2 POLG2

9.26e-0618411762c8e9ddce3e60302965dcf9dee77c4fe33e4071d
ToppCell367C-Lymphocytic-NK_cells-NK_cell_A|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

PIK3AP1 XK S1PR5 CD247 SLC16A3 MOCS3

9.55e-06185117625781cf68e693e97dc1885e2879ab24fa946b51e
ToppCellwk_08-11-Hematologic-Myeloid-Cycling_DC|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

DOCK8 SIGLEC5 CYP2S1 NOD2 P2RY6 IFI30

9.84e-061861176de1f0bc5dbf6dc0e716f5ebbf2bbcfe249811c54
ToppCellTCGA-Skin-Primary_Tumor-Melanoma-Skin_Cutaneous_Melanoma-6|TCGA-Skin / Sample_Type by Project: Shred V9

UNC93A EVPL SLC15A1 BNIPL GSDMA KLK5

1.01e-0518711762ca7928baf0c5e61f7294ed05e6e6f0e0adf9d3f
ToppCellFetal_29-31_weeks-Immune-monocyte-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

PIK3AP1 ADAM19 DOCK8 DENND3 NOD2 SLC16A3

1.11e-051901176ad297172a74a80ed5c10f921e15efd1da0fd2d6b
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Lymphocytic_T/NK-T_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ADAM19 DOCK8 TMC6 SLFN5 CD247 TMC8

1.11e-05190117607ea0578ca0561077557203ae660530f53fc4067
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Lymphocytic_T/NK-T_Cell-|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ADAM19 DOCK8 TMC6 SLFN5 CD247 TMC8

1.11e-0519011765b4b3eed7aa798bb7e3c5e968c8dc4144e377a5f
ToppCellAdult-Immune-monocyte-D175|Adult / Lineage, Cell type, age group and donor

PIK3AP1 ADAM19 PTGIR NOD2 P2RY6 PLXNC1

1.14e-051911176cbebb4d9550fdcd606cb3685ac9546c6b73fd422
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c11-GNLY|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

ADAM19 STING1 FHIP2A CD247 GPR68 SLC27A2

1.36e-0519711761ca06d6d288cb58a6e8062ebc01831e58ee5be4b
ToppCellnormal_Lung-Endothelial_cells-EPCs|Endothelial_cells / Location, Cell class and cell subclass

PIK3AP1 DOCK8 S1PR5 CD247 TMC8 IFI30

1.36e-051971176bfdde765bf05c5bff88bc3ab5175bfe61e79ed60
ToppCell10x5'v1-week_12-13-Myeloid_neutrophil-granulo-eo/baso/mast-mast_cell|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

GALC NDST2 EVPL STING1 SLFN5 RYR3

1.36e-05197117661f909737c5f630beffdd326c6844215643dbdde
ToppCellBiopsy_IPF-Immune-pDCs|Biopsy_IPF / Sample group, Lineage and Cell type

NAT8L ADAM19 TMEM210 ZNF10 P2RY6 SIGLECL1

1.40e-051981176aa8943e6796f619406056cf763b751fe9a9a3e0c
ToppCellFetal_brain-fetalBrain_Zhong_nature-GW16-Myeloid-Microglia|GW16 / Sample Type, Dataset, Time_group, and Cell type.

PIK3AP1 DOCK8 PIEZO1 TMC6 STING1 TMC8

1.40e-051981176901cd39cb84f1907f2f5d27221979c854bd3b40e
ToppCellFetal_brain-fetalBrain_Zhong_nature-GW16-Myeloid|GW16 / Sample Type, Dataset, Time_group, and Cell type.

PIK3AP1 DOCK8 PIEZO1 TMC6 STING1 TMC8

1.40e-051981176cc292aa8518d5ef8940e2327f2f07d584a996d90
ToppCelldistal-2-Hematologic-Plasmacytoid_Dendritic|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

NAT8L ADAM19 TMEM210 TRPM5 P2RY6 SIGLECL1

1.44e-05199117678796b05d28b35e7361b6271d4a3858faa39c45c
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW16-Mesenchymal|GW16 / Sample Type, Dataset, Time_group, and Cell type.

PIK3AP1 DOCK8 PIEZO1 TMC6 STING1 P2RY6

1.49e-052001176fe22f7c97f4e37dfa7881d0f1d9245c1237d873b
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW16-Neuroepithelial|GW16 / Sample Type, Dataset, Time_group, and Cell type.

CCR10 PIEZO1 TMC6 STING1 CYP2S1 SLC16A3

1.49e-05200117625f4c051c2e869481f33c22ad54de97efac444ad
ToppCellhealthy_donor|World / Disease condition, Lineage, Cell class and subclass

TMC6 SLFN5 S1PR5 CD247 SUN2 TMC8

1.49e-052001176afd4d5609adaa470e3d880f8be4a4d55e162b3d6
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW10-Mesenchymal-BMP_responsible_cell|GW10 / Sample Type, Dataset, Time_group, and Cell type.

PIK3AP1 PIEZO1 TMC6 STING1 DENND3 P2RY6

1.49e-052001176604a88633d4162337e394155c7346dbdef8b9f5a
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW16-Mesenchymal-BMP_responsible_cell|GW16 / Sample Type, Dataset, Time_group, and Cell type.

PIK3AP1 DOCK8 PIEZO1 TMC6 STING1 P2RY6

1.49e-05200117626251ed8c7fa7e87973d6f59bd398c88ad025395
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW16-Neuroepithelial-Proteoglycan-expressing_cell|GW16 / Sample Type, Dataset, Time_group, and Cell type.

CCR10 PIEZO1 TMC6 STING1 CYP2S1 SLC16A3

1.49e-052001176da45a85a4667965b24ba824af871157af5b4cd19
ToppCellTCGA-Blood_and_Bone_Marrow-Primary_Blood_Derived_Cancer_-_Peripheral_Blood-Leukemia-Acute_Myeloid_Leukemia-7|TCGA-Blood_and_Bone_Marrow / Sample_Type by Project: Shred V9

DIPK1B FHIP2A NBAS ZNF610 ZNF528

4.07e-05145117588090a226ddfa6df59976f025bf0fd84ca0f72ef
ToppCellGlobus_pallidus-Endothelial-ENDOTHELIAL_STALK-Flt1_2-Endothelial_Stalk.Flt1.Lcn2_(Vwf)|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

CMKLR2 CCR10 TRPM5 TMEM252

4.34e-057411740288a3f4eafbc359d01cde4ba58f946dd07c77cb
ToppCellGlobus_pallidus-Endothelial-ENDOTHELIAL_STALK-Flt1_2|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

CMKLR2 CCR10 TRPM5 TMEM252

4.34e-0574117457884ade66fe39398351685189df5efd7aea0aab
ToppCellGlobus_pallidus-Endothelial-ENDOTHELIAL_STALK-Flt1_2-Endothelial_Stalk.Flt1.Lcn2_(Vwf)--|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

CMKLR2 CCR10 TRPM5 TMEM252

4.34e-0574117413093139a75bfe11f6b032c9fb402efcc703551c
ToppCellGlobus_pallidus-Endothelial-ENDOTHELIAL_STALK-Flt1_2-Endothelial_Stalk.Flt1.Lcn2_(Vwf)-|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

CMKLR2 CCR10 TRPM5 TMEM252

4.34e-057411747f7de9e8142d2435391ee965cee5628e412f0705
ToppCell356C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_0|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

DIPK1A CDHR1 HEATR5A PGLYRP2 IFI30

4.78e-051501175b6f1fc62d08199fed6156c7cd32f66d9926531b5
ToppCellSmart-seq2-lymph_node_(Smart-seq2)-myeloid-myeloid_granulocytic|lymph_node_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

NDST2 EVPL CACNA1H UGT2B28 RD3

5.09e-05152117532634195048858ae84605c61e43c542d90f7cab5
ToppCellSmart-seq2-lymph_node_(Smart-seq2)-myeloid-myeloid_granulocytic-mast_cell|lymph_node_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

NDST2 EVPL CACNA1H UGT2B28 RD3

5.09e-0515211750eb185b2404f015efff1bd140e0c502d714720fb
ToppCellControl-Myeloid-Neutrophils|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PIK3AP1 DOCK8 SIGLEC5 SLC16A3 PLXNC1

5.25e-051531175c33d63b2d1a220bc428e776b157b23faa43ea8ca
ToppCellControl-Myeloid-Neutrophils-Neutrophils|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PIK3AP1 DOCK8 SIGLEC5 SLC16A3 PLXNC1

5.25e-051531175e3630f2b10f33092a3b6a63dba3a39fbdecbc7bd
ToppCellTCGA-Colorectal-Primary_Tumor-Colorectal_Adenocarcinoma-Rectal_Adenocarcinoma-3|TCGA-Colorectal / Sample_Type by Project: Shred V9

CPZ PTGIR PIGQ S1PR5 P2RY6

5.76e-051561175b464871ad7c8ce0d58013a27996639eac1e526d8
ToppCellsevere_influenza-NK_CD56bright|severe_influenza / disease group, cell group and cell class (v2)

DAB2IP CDHR1 CCDC168 CD247 GPR68

5.94e-051571175fabaf54429dd5a899f9192f0d42522109ca36b9b
ToppCellmetastatic_Brain-Myeloid_cells-CD1c+_DCs|metastatic_Brain / Location, Cell class and cell subclass

ADAM19 DOCK8 PTGIR GPR68 IFI30

6.30e-05159117535a63ca521635389a1edc7c81157793b8ad24d38
ToppCell356C-Myeloid-Macrophage-FABP4+_Macrophage|356C / Donor, Lineage, Cell class and subclass (all cells)

CHST6 ADCY6 NOD2 MOCS3 SLC27A2

6.30e-05159117524f87c666eff10c1844c900ffd7ad49fa9f80481
ToppCellsaliva-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c01-LEF1|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

DIPK1A WDR81 CD247 ABCE1 TMC8

6.69e-0516111752849fbc9611af208241b33da3cd18290aafe426b
ToppCellfrontal_cortex-Non-neuronal-macrophage|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

PIK3AP1 DOCK8 STING1 ITGB5 P2RY6

7.09e-051631175b89f586b444f90047c8ce407f53847fd1ee7cca3
ToppCellfrontal_cortex-Non-neuronal-macrophage-Macrophage|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

PIK3AP1 DOCK8 STING1 ITGB5 P2RY6

7.09e-051631175cbe9b4c4b2e42e9f92a57ed66758af93434db5bb
ToppCell367C-Myeloid-Dendritic-pDC|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

NAT8L DSG2 DIPK1B TMEM210 ZNF10

7.30e-05164117595b800c78871354c859abaa832d778786ef7bcc0
ToppCellCerebellum-Endothelial-ENDOTHELIAL_STALK|Cerebellum / BrainAtlas - Mouse McCarroll V32

PIEZO1 SLFN5 DENND3 SLC16A4 TMEM252

7.51e-0516511757d319a112b9062efee428bef6f4534d2ce782e04
ToppCellNS-critical-d_07-13-Myeloid-pDC|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

NAT8L ADAM19 DIPK1B TMEM210 P2RY6

7.51e-05165117517d5c4a111d9b5400780bc5e7b93ce2f5d69ceb7
ToppCellnucseq-Immune-Hematopoietic-Granulocytic|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

GALC NDST2 RYR3 CACNA1H RD3

7.51e-05165117537615622c736e43260c38016e7c9e565ac97a3e8
ToppCellnucseq-Immune-Hematopoietic-Granulocytic-Mast/Basophil|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

GALC NDST2 RYR3 CACNA1H RD3

7.51e-051651175640bb71e74a61df2fcb01ceeabe4c493ef836b21
ToppCellnucseq-Immune-Hematopoietic|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

GALC NDST2 RYR3 CACNA1H RD3

7.51e-051651175f3df74b5763130c71c0a482a3a23f6b22acc2892
ToppCellPosterior_cortex-Hematopoietic-MICROGLIA-MI2(C1qb)-Tmem119|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

AUP1 DOCK8 HEATR5A STING1 P2RY6

7.73e-051661175063d68f2ffb40770cb4601fa1cb6426ae26f7a37
ToppCellPosterior_cortex-Hematopoietic-MICROGLIA-MI2(C1qb)-Tmem119-MICROGLIA_Microglia.C1qb.Tmem119-Junb_(Microglia)-|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

AUP1 DOCK8 HEATR5A STING1 P2RY6

7.73e-051661175417cfb207da08fa1a0fd5f2a13c8786628667a8e
ToppCellPosterior_cortex-Hematopoietic-MICROGLIA-MI2(C1qb)-Tmem119-MICROGLIA_Microglia.C1qb.Tmem119-Junb_(Microglia)|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

AUP1 DOCK8 HEATR5A STING1 P2RY6

7.73e-051661175f28d07715e6b00ca2a0df39273c5f569744be5a8
ToppCellNS-moderate-d_07-13-Myeloid-pDC|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

NAT8L ADAM19 DIPK1B TMEM210 P2RY6

8.18e-051681175d03e91f0e0518b33555c0ec98124fc5ed0f11be5
ToppCellTracheal-NucSeq-Immune_Lymphocytic-NK-ILC-T_NK-NK_CD11d|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

CMKLR2 CDHR1 CD247 TMC8

8.18e-05871174f92e08c2d1c2f216063ecfd42b06652e558c1a89
ToppCellControl-Mast_cells|Control / group, cell type (main and fine annotations)

GALC NDST2 RYR3 CACNA1H RD3

8.41e-051691175fdb9abca1d0f4fdc32dd8ac6231651ef34aa5afb
ToppCelltumor_Lymph_Node_/_Brain-Myeloid_cells-CD1c+_DCs|tumor_Lymph_Node_/_Brain / Location, Cell class and cell subclass

ADAM19 CCDC168 PTGIR P2RY6 IFI30

8.65e-051701175403b6b749d70d845838dcda7daf99971b50792a2
ToppCellControl-Mast_cells-Mast_cells|Control / group, cell type (main and fine annotations)

GALC NDST2 RYR3 CACNA1H RD3

8.65e-051701175c80f6d29096c372da95a8407f402349ff1bb7018
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Immune-Myeloid-Macrophage_Dendritic-Cycling_Mononuclear_Phagocyte|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

NDST2 SIGLEC5 NOD2 PLXNC1 TMC8

9.13e-051721175ef33b5e0515c6d29fb6d9a673011c1b68ef264f3
ToppCellfacs-Skin-nan-24m-Lymphocytic-nan|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CCR10 PGLYRP2 CD247 PLXNC1 GPR68

9.64e-0517411756863222bec844f40c0c80f5c82a8ff51d1a56d0a
ToppCellfacs-Skin-nan-24m-Lymphocytic|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CCR10 PGLYRP2 CD247 PLXNC1 GPR68

9.64e-0517411755739c1b8d643ad360ef32049832d749c530ca603
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Immune-Lymphocytic_B-B_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PIK3AP1 ADAM19 CD247 PLXNC1 TMC8

9.64e-0517411751b2a2129c08bac01fc638692313b196759a1e0d7
ToppCellfacs-Skin-nan-24m-Lymphocytic-T_cell|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CCR10 PGLYRP2 CD247 PLXNC1 GPR68

9.64e-051741175d570eab215f8287362084e37f35672e20aa0f7a2
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Immune-Lymphocytic_B-B_Cell-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PIK3AP1 ADAM19 CD247 PLXNC1 TMC8

9.64e-0517411755bde24eb588dc588efc413811379548120ec0c7f
ToppCellmild_COVID-19-pDC|mild_COVID-19 / disease group, cell group and cell class (v2)

NAT8L DSG2 TMEM210 P2RY6 MYMX

9.91e-051751175b87f279a7519710146c49d6acccb0adedc195965
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2-Exc_L6_FEZF2_FAM95C|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

TSPAN18 CPZ RYR3 CACNA1H NPY

9.91e-05175117590e29945aa861082c94bb4f331161adc3a6ef899
ToppCell3'-Child09-12-SmallIntestine-Epithelial-neuro-epithelial|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FFAR1 PYY EVPL OR51E1 DISP3

1.02e-0417611752e1003dc373b14d27f0464d980453fdcfc1005f0
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Immune-Lymphocytic_B-B_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ADAM19 DOCK8 TMC6 CD247 TMC8

1.02e-041761175274458d80f9f3f080248cbf64e4784ef351e7254
ToppCell5'-GW_trimst-2-SmallIntestine-Hematopoietic-T_cells-ILCP|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

DOCK8 CD247 SLC16A3 PLXNC1 SUN2

1.02e-041761175238244294d08975df6bfa26b2b437db3654408ae
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Immune-Lymphocytic_B-B_Cell-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ADAM19 DOCK8 TMC6 CD247 TMC8

1.02e-041761175d0a3e176df1270968efa79c00dc941c5e1c4f7aa
ToppCellDendritic_Cells-Cryobiopsy_01|World / lung cells shred on cell class, cell subclass, sample id

ADAM19 CYP2S1 PTGIR P2RY6 PLXNC1

1.05e-041771175d2cd081bdda0eba9f6f6473c4d3939e4bee3440e
ToppCellControl-Myeloid-pDC|Control / Disease state, Lineage and Cell class

NAT8L ADAM19 DSG2 ZNF10 P2RY6

1.05e-0417711753940663bb5b45b2ca9f772550380a516c53e410b
ToppCellBAL-Mild-Lymphocyte-T/NK-CD4+_T-CD4+_T_Exhausted-|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

ADAM19 PGLYRP2 STING1 SLFN5 CD247

1.05e-04177117528f2ea29a52de90301e6ba770f407ee4034936d5
ToppCellControl-Myeloid-pDC|Myeloid / Disease state, Lineage and Cell class

NAT8L ADAM19 DSG2 ZNF10 P2RY6

1.05e-041771175e82115bfc32c7b689460fbc5caeb983c1aabe30f
ToppCellBAL-Mild-Lymphocyte-T/NK-CD4+_T-CD4+_T_Exhausted|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

ADAM19 PGLYRP2 STING1 SLFN5 CD247

1.05e-041771175f87bbc9403e909bb534eb705bcd2bca83d072cc7
ToppCellfacs-Large_Intestine-Proximal-18m-Epithelial-Brush_cell_of_epithelium_proper_of_large_intestine|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SIGLEC5 SLFN5 TRPM5 NNMT NPY

1.07e-04178117509a215a0d6e98e4bb920cabda12af08ff4de3c98
ToppCell3'-Broncho-tracheal-Immune_Myeloid-Dendritic-plasmacytoid_dendritic_cell-Plasmacytoid_DCs-Plasmacytoid_DCs_L.1.5.1.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

NAT8L ADAM19 P2RY6 SIGLECL1 MYMX

1.10e-041791175c9f45cfea0ceb0cdc31bcfd123aeab69aeb35c35
ToppCellControl-Myeloid-Monocytes,_Macrophages|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PIK3AP1 SIGLEC5 NOD2 PLXNC1 IFI30

1.10e-041791175a79a244bf8ecc333d034b2eb2de554d3310ca6de
ToppCellControl-Myeloid-Monocytes,_Macrophages-Monocytes-Macrophages|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PIK3AP1 SIGLEC5 NOD2 PLXNC1 IFI30

1.10e-041791175c4ff8b191ed0f6dc2dd784869f6f2c62e170a7db
ToppCellRSV-Healthy-0|RSV / Virus stimulation, Condition and Cluster

ORC6 S1PR5 SUN2 NUP160 SDHD

1.13e-041801175974044056e2f7e909cb11c6f6ca89e58bf95f7e5
ToppCellmoderate-Myeloid-pDC|moderate / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

NAT8L ADAM19 DIPK1B TMEM210 P2RY6

1.13e-041801175a0751ad5e42a21cb107d900abfa9ee967a0069fc
ToppCellNS-moderate-d_16-33-Myeloid-pDC|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

NAT8L ADAM19 DIPK1B TMEM210 P2RY6

1.13e-041801175144818e69613296cde43f29cb8c20899c670b319
ToppCelldroplet-Tongue-Unstain-18m-Epithelial-suprabasal_interpapillary|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CYP2S1 PRSS27 GSDMA KLK5 MYMX

1.13e-04180117518bf8561ad3aa9787d2a8ef942a96f641734c608
ToppCellAdult-Immune-T_lymphocyte-D122|Adult / Lineage, Cell type, age group and donor

ADAM19 DOCK8 DIPK1A CD247 TMC8

1.13e-04180117506c371d0f0c5a7b234dd143e98800e19af95a8b5
ToppCellRSV-Healthy-0|Healthy / Virus stimulation, Condition and Cluster

ORC6 S1PR5 SUN2 NUP160 SDHD

1.13e-041801175703a1d0f9536af94d56757eb01221878d7b7fe61
ToppCell3'_v3-Lung-Myeloid_Dendritic-pDC|Lung / Manually curated celltypes from each tissue

ADAM19 DSG2 TMEM210 P2RY6 SIGLECL1

1.16e-0418111753d7f089fb434fbc989f1fa159e22133ae00b2487
ToppCellCOVID-19-kidney-Mito-rich_(Imm)|kidney / Disease (COVID-19 only), tissue and cell type

TMC6 NOD2 CD247 PLXNC1 TMC8

1.16e-0418111758448c2ad560cfd48bfe9dc1dd3a64373e6a622dd
ToppCellCTRL-Myeloid-cDC|Myeloid / Disease state, Lineage and Cell class

ADAM19 CYP2S1 PTGIR P2RY6 PLXNC1

1.19e-041821175ee137574b8f0e684a4a7cb26226877c471cae433
ToppCellhealthy_donor-Myeloid-Monocytic-SC_&_Eosinophil|healthy_donor / Disease condition, Lineage, Cell class and subclass

DSG2 DIPK1B ADCY6 RYR3 SLC27A2

1.19e-0418211756bd6c32c48fecd6d03ac8a09e405b3b99bdc12ae
ToppCellCOPD-Myeloid-Mast|World / Disease state, Lineage and Cell class

GALC RYR3 NBAS CACNA1H RD3

1.19e-04182117568a1e7b804f309bfd6c23d65fad20a9a962712ae
ToppCellControl-Lymphocytic_NKT-iNKT/MAIT|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PIK3AP1 DOCK8 S1PR5 CD247 PLXNC1

1.22e-04183117559e8d07556390828f7557ba3fd2f7d49851498b7
ToppCellcellseq2-Immune-Immune_Myeloid-Myeloid_Dendritic-cDC2|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

PIK3AP1 SLC16A3 P2RY6 PLXNC1 IFI30

1.22e-0418311759840706f972387241bf1d4ba8af25efc3214a91b
ComputationalGenes in the cancer module 71.

XK SLC16A4 SLC16A3 SLC9A6

8.73e-0622664MODULE_71
ComputationalGenes in the cancer module 500.

NDST2 CD247 P2RY6 ABCE1

3.15e-0530664MODULE_500
ComputationalGenes in the cancer module 218.

SLC16A4 SLC16A3 SLC15A1

2.34e-0420663MODULE_218
ComputationalNeighborhood of MATK

S1PR5 CD247 SUN2

4.08e-0424663GNF2_MATK
DiseaseEPIDERMODYSPLASIA VERRUCIFORMIS, SUSCEPTIBILITY TO, 1

TMC6 TMC8

1.53e-0521162C4722564
Diseaseepidermodysplasia verruciformis (is_implicated_in)

TMC6 TMC8

1.52e-0451162DOID:13777 (is_implicated_in)
DiseaseEpidermodysplasia Verruciformis

TMC6 TMC8

1.52e-0451162C0014522
DiseaseTrypanosoma cruzi seropositivity

CD247 SDHD

3.18e-0471162EFO_0005530
Diseasechildhood absence epilepsy (is_implicated_in)

CACNA1H NPY

4.22e-0481162DOID:1825 (is_implicated_in)
DiseasePeripheral Nervous System Diseases

XK CACNA1H NPY

1.27e-03541163C4721453
DiseaseGlobal developmental delay

FHIP2A TRRAP PIGQ NBAS

1.91e-031331164C0557874
DiseaseAnorexia

PYY NPY

2.25e-03181162C0003123
Diseasenevus count

DOCK8 RD3

2.25e-03181162EFO_0004632
DiseaseSystemic Scleroderma

S1PR5 CD247

2.51e-03191162C0036421
DiseaseSevere Combined Immunodeficiency

CD247 PRKDC

2.78e-03201162C0085110
Diseaseasthma

ADAM19 HEATR5A ITGAV NOD2 CD247 PLXNC1 GSDMA ARHGAP27 NNMT

2.90e-037511169MONDO_0004979

Protein segments in the cluster

PeptideGeneStartEntry
SGLALARCGLNPVLY

CCR10

296

P46092
LGACLVLLQSGYKIP

DISP3

1371

Q9P2K9
LGLLRLCLAQANFAP

CDHR1

11

Q96JP9
NALCILLYPGLILID

ALG6

146

Q9Y672
GAARLCLLAFALQPL

ADAM19

6

Q9H013
PQPAYVALLACAAAL

ADCY6

176

O43306
PRLCALYAGLSLLQQ

GSDMA

426

Q96QA5
AVLLLLAGLYRGQAL

FGFR4

381

P22455
LYLNLESCRCLPRGL

FBXL6

501

Q8N531
LLGLLPAAYLNPCSA

SDHD

76

O14521
LAKVCALLRGYLLPG

DIPK1B

366

Q5VUD6
CFLAPDNSLLLARYL

DENND3

546

A2RUS2
LTALLLTCPGALQAY

PIK3AP1

351

Q6ZUJ8
LALLVCLGALVDAYP

PYY

16

P10082
FGPLVLLCYALRLNF

OR5D14

156

Q8NGL3
LLCYALRLNFSGPNV

OR5D14

161

Q8NGL3
LAALCQFGLLPLLAF

SLC10A4

141

Q96EP9
GRAYALLLLLICFNV

DSG2

6

Q14126
YLGLCAALEPILSAK

DAB2IP

356

Q5VWQ8
LAGLACAPIKINIIY

OR52E4

186

Q8NGH9
YRAALCNLASLLKPG

INMT

176

O95050
CALSPLGQLLQDRYG

SLC16A3

161

O15427
QCLAGLPCLEYLRLR

LRRC61

116

Q9BV99
YPLLLCLLLAQLGLG

GPR158

6

Q5T848
ALLGCSKYAELLLIP

HERC1

2521

Q15751
GLNAVILFASCYLPR

BNIPL

211

Q7Z465
LLGNLLQLRPGALYS

CYP2S1

41

Q96SQ9
LLAYLLALAAPGRGA

PLXNC1

21

O60486
FPLCSLYLIAVLGNL

OR51E1

31

Q8TCB6
CLLLPAARLARQYLL

MYMX

16

A0A1B0GTQ4
LTKALRYLQQPGCLL

PGP

181

A6NDG6
CAVRAGLLRPDYALL

PGLYRP2

506

Q96PD5
YCRALRNLGSLLKPG

NNMT

176

P40261
SGLLLLPAALEGYRC

EVPL

2006

Q92817
LALCALVYRLQPGLL

MICAL1

541

Q8TDZ2
CLDLVNKRLPYGLAQ

POLG2

196

Q9UHN1
QAALLLRPNQLYCGA

KLK5

81

Q9Y337
CQGAASRPAILYALL

NR0B2

11

Q15466
APLYACLLGLCALLP

ITGB5

6

P18084
AYLLALPQVLDANRC

NBAS

1546

A2RRP1
LLSLLLPLEQNECYL

DRC1

511

Q96MC2
ASYLCFRLLGAALPL

MYBBP1A

301

Q9BQG0
AQAPGLYQRLSLCTL

METTL27

106

Q8N6F8
LYQRLSLCTLGQEPL

METTL27

111

Q8N6F8
ALALCLGKPADVYLI

ABCE1

471

P61221
VNLCSPYLLLRRAVL

HEATR5A

1071

Q86XA9
CSEYLLGNPRIQRLL

CPZ

266

Q66K79
LPILLNERLQTGSYC

DOCK8

671

Q8NF50
LRLTPSLVYALNLGC

FFAR1

36

O14842
ERSLPLCLQLYAPGL

IFI30

156

P13284
AQSFGLLDPKLCYLL

CD247

21

P20963
SGLLLPLCRAFNLDV

ITGAV

21

P06756
LGCLHLLYFLLRQPQ

LCAT

206

P04180
ALPLALLCNGKNYSL

CCDC168

4906

Q8NDH2
LLDPYVNLAPGCRSL

FHIP2A

676

Q5W0V3
LLKLLACGPLGYIRN

CACNA1H

841

O95180
LLLCALLAPGGAYVL

GALC

31

P54803
ACQLLKDYLLRGAPS

DIPK1A

366

Q5T7M9
ALCYLTPILGALIAD

SLC15A1

61

P46059
LGRLDACSTVLPLYA

S1PR5

176

Q9H228
RYLVNDACVLAGRPL

MOCS3

186

O95396
LNLALADLLYACSLP

P2RY6

66

Q15077
FPICLLLASYQGILR

GPR68

196

Q15743
CPLRRGALLLLSIYF

STING1

91

Q86WV6
AANIYPLSLLLNLGR

SLC9A6

426

Q92581
ALLLLLGQATADPCY

NTN5

6

Q8WTR8
GLLFLPLLVNLCCPY

SLC27A2

11

O14975
PYSLLRLLACQSLLF

TDRD12

551

Q587J7
INSLPLYSLGLRLCR

PIGQ

491

Q9BRB3
QRSSLAPGLPACLYL

ARHGAP27

131

Q6ZUM4
LAALCFGLAALYAPV

SFT2D3

86

Q587I9
YAGIVIALLFLCLLP

SIGLECL1

121

Q8N7X8
YLPVLEGQALRLLCD

SIGLEC5

256

O15389
CPLDRAYLIKLSGLN

ORC6

61

Q9Y5N6
SYCGPAILRFRQLLA

RD3

91

Q7Z3Z2
LAALNCLRLIRPEYA

NUP160

1126

Q12769
LTPRQFALLCPALLY

SLC39A5

176

Q6ZMH5
GLAFLNSCLNPILYV

CMKLR2

291

P46091
QELCAGALQLLGYRP

CHST6

346

Q9GZX3
EPVRRQGNYLLCSLL

CNNM2

306

Q9H8M5
DCFLLLVLLLYAPVG

AUP1

21

Q9Y679
NYRNLVFLGICLPDL

ZNF610

56

Q8N9Z0
LQLLCGLLAGLAYAA

RHBDD3

166

Q9Y3P4
LSLLLIPAAAGTYCE

TMEM210

21

A6NLX4
LALYSGIAPALLRQA

SLC25A14

101

O95258
CPVSYLLLCGQAALL

TM2D2

6

Q9BX73
IRLAYLLSPLACLLL

TMC8

201

Q8IU68
LGAFLCPALVYTNLI

TRPM5

651

Q9NZQ8
SYLILCGITNLLAPL

SLC16A4

371

O15374
LPCLGVCKALYLRDN

NOD2

811

Q9HC29
FLLPLLLLTCLTYGA

SUN2

216

Q9UH99
CAALLRRQTSGPLYL

RNLS

16

Q5VYX0
LYAQLDGPRCARLAL

PTGIR

126

P43119
AVPLLLLLCFGSQRA

PRSS27

6

Q9BQR3
LALNRYICSAVLPLL

RYR3

2411

Q15413
LSLLVCLGALAEAYP

NPY

16

P01303
QLCQLYPRLKVLAFG

TMEM214

341

Q6NUQ4
RLCLLILLPLYSGLQ

UNC93A

256

Q86WB7
LALRSLQNRCLVPGY

NDST2

741

P52849
VALPLALLGLYPALC

PRRT4

611

C9JH25
GLLYALRIPLRLCEN

ST7L

51

Q8TDW4
CQGSLIAAYLLLPLG

TMEM252

36

Q8N6L7
LLYLRGPFSLQATLC

PRKDC

1241

P78527
GNCLLPAQLVLREYF

ZNF10

171

P21506
LAALLLPLCFVDYGV

TMEM245

121

Q9H330
AANPLLLTGAYILLA

TSPAN18

46

Q96SJ8
YRNLVSLGICLPDLS

ZNF528

41

Q3MIS6
LALFRLLTLPCYGLR

TAPT1

136

Q6NXT6
LLNLGAPYLCRVLAA

TMC6

481

Q7Z403
PGVLLLLCYATASLR

PIEZO1

316

Q92508
NYRNLVSLGICLPDL

ZNF766

41

Q5HY98
CGELLAALLNIPFVY

UGT2B28

156

Q9BY64
AILQAGGLADCLLYL

TRIP12

556

Q14669
RIAALNALAACNYLP

TRRAP

1366

Q9Y4A5
PAGAYNLLLCLASRA

SLFN5

866

Q08AF3
VCAPLLVLQLLIGYC

XK

346

P51811
ARNLLRLLTSCYVGP

WDR81

1246

Q562E7
LPILTQCASLRYLGL

LRRC14

386

Q15048
LLTCLVPAALLGLRY

NAT8L

136

Q8N9F0